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401 | Оценить эффективность комплексной терапии желудочно-кишечных болезней поро-сят в ранний постнатальный период в условиях промышленного свиноводства с ис-пользованием рекомбинантного видоспецифичного цитокина ГМ-КСФ. | [
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402 | Предмет и объект исследований. | [
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403 | Предметом исследования являлось мор-фофункциональное состояние тонкого отдела кишечника, морфо-биохимические показатели крови и уровень экспрессии генов ИЛ-1 и ИЛ-10 при комплексной те-рапии желудочно-кишечных заболеваний поросят с использованием рекомбинант-ного видоспецифичного цитокина ГМ-КСФ. | [
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404 | Объектом исследования служили по-росята в возрасте от 3 до 10 дней. | [
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405 | Научная новизна исследований. | [
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406 | В результате комплексных исследований изучена морфологическая и функциональная характеристика тонкого отдела ки-шечника у поросят в раннем постнатальном периоде в норме, при желудочно-кишечных болезнях и комплексной терапии с использованием рекомбинантного видоспецифичного цитокина ГМ-КСФ. | [
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407 | Изучено реверсирование биохимических, гематологических и гемостатических показателей крови у здоровых, больных жи-вотных и поросят после проведенной комплексной терапии. | [
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408 | Получены новые зна-ния об уровне экспрессии генов про- и противоспалительных цитокинов при ком-плексной терапии желудочно-кишечных болезней с применением рекомбинантно-го видоспецифичного цитокина. | [
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409 | Впервые проведено иммуногистохимическое ис-следование тонкого отдела кишечника поросят с использованием моноклональных антител CD-3 и KI-67 при комплексной терапии с использованием рекомбинантно-го видоспецифичного цитокина ГМ-КСФ. | [
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410 | Разработан и предложен эффективный способ лечения желудочно-кишечных болезней поросят в ранний постнатальный период. | [
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411 | Теоретическая и практическая значимость работы. | [
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412 | Расширено современ-ное представление о морфофункциональном состоянии тонкого отдела кишечника при желудочно-кишечных заболеваниях поросят в раннем постнатальном периоде. | [
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413 | Для оценки состояния организма больных поросят в раннем постнатальном пери-оде рекомендовано проводить биохимические, морфологические, гемостатические и молекулярно-генетические исследования крови. | [
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414 | Разработана и предложена более эффективная схема комплексной терапии желудочно-кишечных болезней поросят в ранний постнатальный период. | [
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415 | Результаты исследований используются в учебном процессе ФГБОУ ВО «Воронежский государственный аграрный университет им. | [
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416 | императора Петра I», ФГБОУ ВО «Саратовский государственный университет ге-нетики, биотехнологии и инженерии имени Н.И. | [
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417 | Вавилова», ФГБОУ ВО «Донской государственный технический университет», ФГБОУ ВО «Донской государствен-ный аграрный университет», при проведении лекций и лабораторно-практических занятий, а также в практической работе ветеринарными специалистами при лече-нии поросят с желудочно-кишечной патологией. | [
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418 | Методология и методы исследований. | [
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419 | Для достижения цели и решения по-ставленных задач испoльзoваны гематoлoгические, биoхимические, гемостатические, бактериoлогические, гистологические, цитологические, иммуногистохимические, мoлекулярнo-генетические и статистические методы исследований. | [
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420 | Область применения: ветеринария, животноводство, ВУЗы зооветеринарного профиля. | [
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421 | Клинико-лучевая картина у пациентов с дегенеративным стенозом поясничного и крестцового отделов позвоночника от уровня L3 до S1 арактеризуется одноуровневым поражением на уровнях L4-L5 и L5-S1 с частотой от 70% до 80%, двухуровневым в 20-27%, выраженным болевым синдромом в ногах в 79% наблюдений и корешковым синдромом в виде пареза – у 43% пациентов, гипотрофией мышц у 32% больных и отсутствием физиологического поясничного лордоза – у 68% больных и патологическим нарушениями позвоночно-тазовых взаимоотношений в виде ретроверзии таза и уменьшения наклона крестца – у 63% пациентов, что находит своё отражение в самочувствие пациентов. | [
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422 | Сформированный новый нейроортопедический подход к декомпрессивно-стабилизирующим вмешательствам на поясничном и крестцовом отделах позвоночника включает выполнение полноценной декомпрессии спинного мозга и его элементов по технологии TLIF, а также восстановление физиологических параметров поясничного лордоза и показателей позвоночно-тазовых соотношений путем установки ригидного межтелового имплантата, спинальной конструкции и выполнения PO и SPO остеотомий, что позволило снизить болевой синдром на 53% по шкале ВАШ и улучшить качество жизни пациента на 32% по шкале ODI и на 8 баллов по шкале RDQ от предоперационного состояния. | [
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423 | Применение нейроортопедического подхода даже при короткосегментных декомпрессивно-стабилизирующих вмешательствах уже через 6 месяцев после оперативного лечения достоверно (при уровне значимости p<0,017) улучшает послеоперационные показатели уровня болевого синдрома по ВАШ в среднем на 11% и уровень качества жизни по шкалам ODI (на 13,5%) и RDQ (на 2,8 балла) во всех исследуемых группах по сравнению с контрольной группой. | [
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424 | Разработанный алгоритм диагностики и хирургического лечения включает комплексную оценку неврологического статуса, степени стеноза позвоночного канала по данным МРТ, оценку параметров позвоночно-тазовых взаимоотношений, декомпрессию невральных структур с коррекцией сегментарного лордоза и восстановления позвоночно-тазовых соотношений на уровне поражения по данным сагиттальной рентгенографии с учётом технических возможностей имеющегося рентген оборудования. | [
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425 | 1) Особенностями течения беременности у женщин с новой коронавирусной инфекцией является увеличение выявления железодефицитной анемии чаще в 4 раза, плацентарных нарушений – в 2,2 раза, гипоксии плода – в 7 раз. | [
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426 | 2) Оценка системы гемостаза у беременных с НКВИ показала следующие изменения: преобладали гипо- и гиперфибриногенемия, повышение уровней МНО, АЧТВ, ПВ. | [
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] |
427 | Уменьшение Д-димеров у беременных происходило в 4,5 раза при назначении НМГ. | [
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428 | 3) Дефицит уровня витамина Д является фактором, влияющим на параметры гемостаза, и при его снижении в 2,8 раза увеличивающим риск утяжеления течения НКВИ у беременных. | [
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429 | Дефицит уровня фолатов в сыворотке крови статистически значимо влияет на возможность инфицирования НКВИ при ее снижении в 2 раза по сравнению с группой контроля. | [
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430 | 4) Разработанный и внедренный алгоритм ведения беременных пациенток с НКВИ Covid-19 является эффективным: железодефицитная анемия снижалась на 66,7%, преэклампсия – 13,3%, синдром задержки развития плода – 10%, преждевременные роды – 23,4%, число кесарева сечения – в 3,2 раза; инфицирование НКВИ Covid-19 было ниже в 2,4 раза, легкая степень диагностировалась в 1, 4 раза реже, средняя степень – в 6,0 раз реже. | [
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431 | В данном исследовании была поставлена цель определить роль и место поселений Северо-Восточного Прикаспия в исторической географии Золотой Орды. | [
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432 | Для достижения этой цели были сформулированы задачи, включающие анализ природно-географических особенностей региона, изучение письменных источников, рассмотрение этапов изучения археологических памятников, анализ топографии поселений, исследование традиций градостроительства, характеристика погребальных памятников, выявление влияния торговых путей и караван-сараев, а также оценка роли и места поселений в исторической географии Золотой Орды. | [
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433 | Исследование базировалось на более чем 50 отчетах археологических исследований, проведенных в регионе Северо-Восточного Прикаспия с 1937 по 2009 годы. | [
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434 | Исследователи обращались к архивам и музейным фондам, где хранились материалы об археологическом изучении памятников. | [
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435 | Научная новизна исследования заключается в том, что впервые был проведен анализ археологического материала из памятников Северо-Восточного Прикаспия в контексте исторической географии Золотой Орды. | [
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436 | Были выявлены связи с другими регионами, определены особенности градостроительства, анализированы торговые пути и караван-сараи, а также проанализированы материалы о погребальных обрядах. | [
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437 | Результаты исследования имеют практическую значимость, так как могут быть использованы в образовательных целях для студентов и исследователей, интересующихся археологией и историей Золотой Орды. | [
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438 | Основные положения работы были представлены на научных конференциях и опубликованы в периодических изданиях. | [
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439 | Таким образом, исследование позволило более глубоко понять роль и место поселений Северо-Восточного Прикаспия в исторической географии Золотой Орды. | [
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440 | Эпилепсия — это хроническое и сложно поддающееся лечению неврологическое заболевание, которым страдают миллионы людей. | [
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441 | Она характеризуется предрасположенностью к возникновению спонтанных эпилептических припадков и может сопровождаться различными психиатрическими и неврологическими проявлениями. | [
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442 | В 40% случаев эпилепсия является приобретенной, в связи с чем предотвращение развития данного заболевания у пациентов из группы риска является важной медицинской проблемой. | [
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443 | Трудности в профилактике и лечении эпилепсии связаны с недостаточным знанием патогенетических механизмов ее развития. | [
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444 | Для успешного решения этой проблемы требуется расширить существующие представления о механизмах, лежащих в основе развития эпилепсии. | [
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445 | Целью данной работы было проведение анализа изменений экспрессии генов ионотропных и метаботропных рецепторов глутамата в различных областях мозга крыс в моделях острых судорог и эпилепсии. | [
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446 | Исследование выполнялось на пентилентетразоловой модели острых судорог и литий-пилокарпиновой модели височной эпилепсии. | [
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447 | Анализ экспрессии генов ионотропных и метаботропных рецепторов глутамата проводился в дорзальной и вентральной областях гиппокампа, а также височной коре крыс методами обратной транскрипции с последующей полимеразной цепной реакцией в реальном времени и вестерн-блоттинга. | [
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448 | Изменения экспрессии генов субъединиц NMDA- и AMPA-рецепторов были обнаружены в обеих использованных моделях, однако они были более выражены в модели эпилепсии и сохранялись до хронической фазы (для которой характерно развитие спонтанных рецидивирующих судорог). | [
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449 | Показано, что продукция мРНК метаботропных рецепторов глутамата практически не меняется при острых судорогах, в то время как в литий-пилокарпиновой модели эпилепсии и в латентную (судороги не проявляются) и в хроническую фазы выявлены существенные изменения, которые могут вносить вклад в эпилептогенез. | [
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450 | Впервые получено описание изменений экспрессии генов ионотропных и метаботропных рецепторов глутамата в различных областях мозга крыс. | [
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] |
451 | Показано, что выявленные изменения были регион-специфичными. | [
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452 | В модели острых судорог изменения экспрессии генов рецепторов глутамата обнаружены только в дорзальной области гиппокампа и височной коре крыс. | [
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453 | В литий-пилокарпиновой модели эпилепсии изменения продукции мРНК ионотропных и метаботропных рецепторов глутамата изменения затрагивают также и вентральный гиппокамп, изменения в котором были даже более выражены, чем в дорзальном гиппокампе. | [
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454 | Данные, полученные в настоящем исследовании, углубляют понимание патологических изменений, происходящих в глутаматергической системе мозга, в процессе эпилептогенеза. | [
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455 | Они могут быть использованы для разработки новых методов лечения эпилепсии, в частности, использование агонистов метаботропных рецепторов III группы в сочетании с другими фармакологическими агентами может быть перспективным подходом к предотвращению развития эпилепсии. | [
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456 | Цель работы: повышение эффективности очистки семян рапса применением сепаратора по упругим свойствам отражающей поверхности и семян. | [
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457 | Объект исследования: технологический процесс очистки семян рапса в сепараторе по упругим свойствам отражающей поверхности и семян. | [
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458 | Научная новизна: Выявлены взаимосвязи между конструктивными параметрами и режимом работы сепаратора и показателями качества очистки семян рапса. | [
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] |
459 | Обоснованы основные конструктивные параметры сепаратора, обеспечивающие повышение эффективности очистки семян. | [
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460 | Практическая значимость: Обоснованы конструктивные параметры сепаратора по упругим свойствам, обеспечивающего получение семян, соответствующих ГОСТ. | [
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461 | Разработана математическая модель, позволяющая на стадии проектирования определять влияние различных факторов на производительность сепаратора и качество очистки семян рапса. | [
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462 | Полученные результаты могут использоваться в НИИ и КБ для разработки конструкции сепараторов по упругим свойствам семян и при проектировании технологических линий очистки семян рапса. | [
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463 | Внедрены в производственно-хозяйственной деятельности ООО «Пичугино» Варгашинского района, ООО «МКТ-АГРО» Сафакульевского района, ИП «Аристов Евгений Андреевич» Половинского района Курганской области. | [
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464 | Обоснованы конструктивные параметры сепаратора: высота падения семян – 0,3 м; угол наклона отражающей поверхности – 25°; радиус отражающей поверхности – 0,25 м; расстояние от отражающей поверхности до бункера очищенных семян – 0,2 м; частота вращения вала с очистителем дозатора и отражателем – 2 об/мин. | [
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465 | Официальные оппоненты: д.т.н., профессор Сабиев У.К., к.т.н., доцент Бадретдинов И.Д. | [
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466 | Ведущая организация – ФГБОУ ВО «Алтайский государственный аграрный университет». | [
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467 | Научный руководитель – д.т.н., профессор Фоминых А.В. | [
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470 | Теоретические исследования движения зерна по решету, совершающему колебания в своей плоскости / А.В. | [
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474 | Ковшова // Вестник Курганской ГСХА. | [
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475 | – 2019. | [
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480 | Лопарев Д. В. Экспериментальные гистограммы дальности отскока от отражательной поверхности семян рапса и сорняков / Д. В. Лопарев // Вестник Курганской ГСХА. | [
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494 | Loparev D.V. | [
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495 | Experimental studies of grain material separation by a sieve track / Yu.N. | [
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496 | Mekshun, D.V. | [
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497 | Loparev, S.G. Lopareva, A.V. | [
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498 | Fominykh // IOP Conference Series: Earth and Environmental Science. | [
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