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700 | Проведен анализ осведомленности врачей-ортодонтов г. Екатеринбурга об особенностях диагностики и лечения пациентов с зубочелюстными аномалиями и нарушениями височно-нижнечелюстного сустава. | [
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701 | На первом этапа работы проведено анкетирование и клиническое обследование 200 пациентов 18-44 лет с зубочелюстными аномалиями. | [
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702 | На 2 этапе – комплексное обследование 120 пациентов основной группы – I и группы сравнения – I. На третьем этапе исследования проведено лечение пациентов с зубочелюстными аномалиями и функциональными нарушениями височно-нижнечелюстного сустава. | [
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703 | В ходе исследования предложена авторская методика исследования височно-нижнечелюстного сустава (патент РФ №2797188) и стабилизации положения нижней челюсти (патент РФ №2783146). | [
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704 | После лечения проведен анализ изменения параметров качества жизни пациентов с использованием опросника SF-36. | [
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] |
705 | Объект исследования: процесс формирования социально-адаптированной личности детей-сирот в учреждениях для детей-сирот (УДС). | [
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706 | Предмет исследования: организация наставнической деятельности волонтеров социально ориентированных некоммерческих организаций (СОНКО) при работе с детьми-сиротами в условиях взаимодействия УДС и СОНКО. | [
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707 | Цель исследования: обосновать, разработать и экспериментально доказать эффективность модели организации наставнической деятельности волонтеров социально ориентированных некоммерческих организаций при работе с детьми-сиротами в целях формирования социально-адаптированной личности. | [
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708 | Достоверность научных результатов обеспечивается их основательной теоретической и эмпирической базой, применением научных методов, логичнстью построения теоретико-методологических оснований последовательным методическим обоснованием изучаемой проблемы, адекватным цели и задачам исследования; репрезентативностью выборки; надежностью эмспирических данных, полученных посредством использования совокупности специальных исследовательских процедур; применением количественного и качественного анализа; корреляцией результатов, полученных автором, с результатами других исследователей. | [
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709 | Научная новизна результатов исследования: разработана и экспериментально апробирована деятельность волонтеров СОНКО в качестве наставников при работе с выпускниками УДС как совместной деятельности учреждения для детей-сирот, социально ориентированной некоммерческой организации и наставника-волонтера, основанной на глубокой взаимной интеграции всех сторон с целью досьтжения максимальной социальной адаптации детей-сирот (воспитанников УДС), выражающейся в высоком уровне жизнестойкости у выпускников УДС. | [
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710 | Проведен комплексный анализ сведений из разных баз данных, касающихся влияния ХБП на здоровье населения России: заболеваемость от почечной недостаточности и смертность от «других болезней мочевыделительной системы» (код N39 по МКБ-10) из форм федерального статистического наблюдения, смоделированная заболеваемость и смертность от ХБП из международных баз данных. | [
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711 | Выявлены актуальные проблемы оказания медицинской помощи пациентам с болезнями почек в субъектах РФ на основании экспертного опроса главных внештатных специалистов (ГВС) нефрологов региональных органов управления здравоохранением. | [
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712 | Определены затраты системы ОМС на 1 пациента с ХБП в год в зависимости от стадии заболевания и условий оказания медицинской помощи. | [
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713 | Доказано на примере крупного субъекта РФ, что фактические затраты системы ОМС на ведение 1 пациента с ХБП в амбулаторных условиях, условиях дневного и круглосуточного стационаров возрастают с увеличением стадии ХБП и достигают максимума на 5-й диализной стадии; в структуре затрат системы ОМС на оказание медицинской помощи при ХБП преобладают затраты на диализ в дневном стационаре, в то время как большинство пациентов получает помощь только в амбулаторных условиях. | [
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714 | Разработана модель оценки клинико-экономической эффективности скрининга на ХБП путем определения уровня креатинина крови в популяции пациентов без факторов риска и страдающих СД типа 2, доказана клинико-экономическая целесообразность скрининга на ХБП в условиях российского здравоохранения c учетом назначения нефропротективной терапии на ранних стадиях заболевания. | [
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715 | На основании полученных результатов предложены практические рекомендации по совершенствованию оказания медицинской помощи пациентам с ХБП в РФ. | [
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716 | В Среднем Предуралье в комплексных исследованиях дано обоснование оптимальным приемам обработки посевов десикантами и клеящими препаратами перед уборкой, предотвращающими растрескивание стручков. | [
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717 | Приведены сведения о сравнительной эффективности синтетических и биологических клеящих препаратов. | [
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718 | Дано научно-практическое обоснование формирования урожайности, проведена оценка урожая по биохимическим показателям и посевным качествам семян. | [
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719 | Дана экономическая и агроэнергетическая оценки технологии выращивания ярового рапса. | [
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720 | В Среднем Предуралье на дерново-мелкоподзолистой тяжелосуглинистой почве для повышения урожайности и сокращения потерь при уборке рекомендуется в технологии возделывания ярового рапса отечественного сорта Ратник предварительно перед уборкой обрабатывать посевы биоклеем Липосам при влажности семян от 35 до 45%. | [
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721 | Уборку проводить прямым комбинированием при влажности семян 12-15%. | [
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722 | Комплексная обработка клеем Бифактор и десикантом Торнадо, на отечественном сорте Ратник и зарубежном гибриде Смилла также позволяет увеличить урожайность, обеспечивая достаточный уровень рентабельности. | [
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723 | Цель: разработка пористых половолоконных подложек из полисульфона (ПСФ) с низким сопротивлением массопереносу газа для задач создания высокопроизводительных композиционных газоразделительных мембран. | [
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724 | Разработаны пористые половолоконные подложки из ПСФ с высокими параметрами газопроницаемости (более 95 м3/м2·ч·атм по СО2), с внешним мезопористым слоем и макропорами 1 – 20 мкм на внутренней поверхности полого волокна. | [
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725 | Впервые была предложена и реализована концепция с подачей внутрь полого волокна инертной по отношению к формовочному раствору жидкости, что позволило минимизировать взаимную диффузию компонентов формовочного раствора и инертной жидкости, и обеспечило выход макропор на внутреннюю поверхность полого волокна. | [
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726 | В качестве инертных жидкостей для формовочных растворов ПСФ в N-метил-2-пирролидоне (НМП) были предложены и исследованы предельные углеводороды (пентан, гексан, гептан), которые являются нерастворителями для ПСФ и ограниченно смешиваются с НМП (растворимость НМП при 20 оС в ряду гептан – гексан – пентан снижается с 5,2 до 3,3 моль.%). | [
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727 | Впервые предложена модифицированная модель сопротивлений, в которой впервые рассматривается более общий вариант, когда толщина проникшего в поры подложки слоя селективного полимера не равняется толщине тонкопористого слоя подложки. | [
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728 | Расчеты позволили впервые установить, что именно изменение глубины проникшего в поры селективного слоя полимера полидецилметилсилоксана (ПДецМС) с 1,7 мкм до 11 мкм является причиной изменения основного пути транспорта газа через композиционные мембраны ПДецМС/ПСФ, что выражается в изменении почти на порядок селективности по паре газов Не/N2 с 6,2 (селективность ПДецМС) до 53 (селективность материла подложки ПСФ). | [
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729 | Височная эпилепсия – широко распространенная форма фокальной эпилепсии человека. | [
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730 | Среди прочих форм фокальных эпилепсий она наиболее часто является фармакорезистентной, поэтому проблема разработки новых методов терапии стоит особенно остро. | [
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] |
731 | Для успешного решения этой проблемы требуется расширить существующие представления о механизмах, лежащих в основе височной эпилепсии. | [
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732 | В настоящее время не существует четкого ответа на вопрос о том, к каким изменениям на нейронном и синаптическом уровнях приводит эпилептическая активность в областях височной доли, нет и четкого представления о сроках происходящих здесь изменений. | [
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733 | В связи с вышеизложенным, целью представленной диссертационной работы было оценить влияние эпилептиформной активности in vitro на биофизические свойства нейронов и глутаматергическую синаптическую передачу в энторинальной коре и гиппокампе крысы. | [
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734 | Эпилептиформная активность in vitro вызывалась с помощью проэпилептического перфузирующего раствора в комбинированных срезах мозга крысы, содержащих энторинальную кору и гиппокамп. | [
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735 | Исследование выполнялось в два этапа: вначале было исследовано, как происходит развитие эпилептиформного состояния в переживающем срезе, затем было оценено, к каким изменениям на нейронном и синаптическом уровне приводит период эпилептиформной активности in vitro. | [
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736 | Было обнаружено, что и гиппокамп, и энторинальная кора активно вовлечены в генерацию эпилептиформной активности in vitro. | [
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737 | В обеих структурах наблюдалась как иктальная, так и интериктальная активность, при этом в энторинальной коре иктальная активность была более продолжительной. | [
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738 | В энторинальной коре было выявлено два типа эпилептиформных разрядов, опосредованных либо сугубо активностью ГАМКа-рецепторов, либо же активностью ГАМКа-, AMPA- и NMDA-рецепторов. | [
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739 | Эпилептиформная активность in vitro не влияла на биофизические свойства нейронов области СА1 гиппокампа и вероятность выброса глутамата в синапсах энторинальной коры и области СА1 гиппокампа, но приводила к постсинаптическим перестройкам. | [
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740 | И в энторинальной коре, и в области СА1 гиппокампа наблюдалось увеличение AMPA/NMDA соотношения. | [
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741 | Наиболее вероятным объяснением изменения соотношения AMPA- и NMDA-рецептор-опосредованных компонент ответа служит встраивание AMPA-рецепторов в постсинаптическую мембрану. | [
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742 | Полученные данные указывают на то, что AMPA-рецепторы играют важную роль в процессах синаптической пластичности, запускаемых эпилептиформной активностью. | [
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743 | Данные о временной динамике изменений AMPA- и NMDA-рецептор-опосредованной синаптической активности могут быть использованы при разработке новых подходов к терапии эпилепсии, в том числе для поиска фармакологических агентов, воздействующих на глутаматергическую передачу. | [
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744 | Основное содержание диссертации изложено во введении и четырёх главах. | [
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745 | В первой главе выполнен обзор современных методов и технических средств диагностирования и обоснована актуальность направления исследования. | [
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746 | Во второй главе описан разработанный аппаратно-программный комплекс для диагностирования механизмов станков, содержащий 3D акселерометр, модуль связи и информационный блок. | [
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747 | Для модуля связи и информационного блока разработаны программные обеспечения (а.с. | [
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749 | № 2023660680), включающие методики выделения диагностических параметров и прогнозирования развития технического состояния станков. | [
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750 | Третья глава посвящена описанию экспериментального исследования станков с использованием стенда и его программных обеспечений. | [
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751 | Получены диагностические параметры, характеризующие разные технические состояния механизмов исследуемых станков. | [
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752 | В четвертой главе, на основе методов нечеткого моделирования и нейро-нечеткого моделирования, изложена методика и результаты обработки экспериментальных данных по прогнозированию развития технического состояния и определение сроков ремонта. | [
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753 | Работа выполнена на предприятии ООО «Нево-Клос», внедрена в производства, что подтверждено справкой о внедрении. | [
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754 | Объект: Текстовые документы, написанные на литературном языке. | [
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] |
755 | Цель: Разработка метода и программных средств обнаружения заимствований между текстами различных языков, в том числе применимого к малоресурсным языкам. | [
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756 | Методы исследования: Применения словаря межъязыковых “синонимов” для представления слов в независимой от языка форме, а также применение модели классификации перевода с учетом рисков быть подвергнутым состязательным атакам. | [
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758 | Метод обнаружения межъязыковых заимствований, превосходящий по эффективности существующие. | [
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759 | Метод применим к задаче обнаружения межъязыковых заимствований в текстах малоресурсных языков. | [
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761 | Метод генерации словаря “межъязыковых” синонимов, позволяющего достичь высоких показателей метрики полноты для этапа извлечения кандидатов в задаче обнаружения межъязыковых текстовых заимствований. | [
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763 | Метод генерации состязательных атак “черного ящика” на языковые модели бинарной классификации, превосходящий по доле успешных атак, а также по дистанции Левенштейна и семантической близости все существующие аналоги. | [
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765 | Методика выбора языковой модели для этапа детального анализа, учитывающая угрозу возможности осуществления состязательных атак. | [
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766 | Внедрение: Результаты внедрены в инструмент обнаружения заимствований “Sieve”, который в свою очередь внедрен в следующих учреждениях: Российско-Армянский Университет; Высший Аттестационный Комитет Республики Армения. | [
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767 | Область применения: Разработка программных средств обнаружения межъязыковых заимствований, которые возможно использовать в работе высших учебных заведений, в том числе тех стран, в которых государственный язык является малоресурсным. | [
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768 | В частности, метод применим в работе с текстами на армянском языке. | [
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769 | Объект исследования – сооружения обработки активного ила, образующегося на станциях биологической очистки городских сточных вод. | [
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770 | Целью диссертационной работы является обоснование и разработка технологии комплексной обработки активного ила для снижения его обсеменённости, включающей процессы аэробной стабилизации и последующее введение щелочного реагента. | [
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771 | Теоретическая значимость результатов исследований: 1. | [
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772 | Доказано влияние биологического преобразования форм азота в процессе аэробной стабилизации на окислительно-восстановительный потенциал среды. | [
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774 | Доказана применимость подходов с биохимическим моделированием ASM 1 для описания процессов аэробной стабилизации избыточного активного ила. | [
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776 | Установлено влияние окислительно-восстановительного потенциала на степень снижения патогенной обсеменённости избыточного активного ила очистных сооружений. | [
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777 | Практическое значение полученных результатов: 1. | [
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778 | На основании выполненных экспериментальных исследований предложен комплексный способ обработки активного ила с целью удаления патогенной обсеменённости ила. | [
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] |
779 | Комплексный метод включает аэробную стабилизацию активного ила с последующим введением щелочного реагента. | [
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780 | Предложенный метод способствует снижению патогенной обсеменённости до требуемых норм при применении ила в качестве удобрительного материала; 2. | [
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781 | Результаты диссертационных исследований внедрены в учебный процесс: лекции по курсу «Малоотходные технологии» для студентов направления подготовки 08.04.01 «Строительство» по программе «Современные методы очистки природных и сточных вод»; 3. | [
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782 | Разработаны «Рекомендации для проектирования комплексной обработки активного ила от патогенной обсеменённости», утвержденные на техническом совете «Компания «Вода Донбасса», 2023 г. Научная новизна полученных результатов: - выполнено теоретическое и экспериментальное обоснование снижения патогенной обсеменённости ила в процессе аэробной стабилизации за счет повышения окислительно-восстановительного потенциала и рН среды; - на основании экспериментальных данных определены стехиометрические коэффициенты биохимической модели ASM 1, описывающие процессы образования окисленных форм азота, влияющих на повышение окислительно- восстановительного потенциала; - определены дозы щелочного реагента, вводимого после аэробной стабилизации осадка в непроточном режиме, для достижения требований использования ила в качестве удобрительного материала. | [
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783 | Объект исследования: общественные отношения, регулируемые на международно-правовом уровне традиционными и новыми международно-правовыми институтами и отраслями международного права, в которых в наибольшей степени сосредоточены (сконцентрированы) пробелы, препятствующие развитию международного права, в частности, те сферы регулирования, которые динамично развиваются под влиянием современного научно-технического прогресса. | [
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784 | Цель исследования: определить природу пробела в международном праве, выявить критерии пробельности и разработать классификацию пробелов, выявить сферы отношений, в которых сосредоточено наибольшее количество пробелов; определить пути, средства, методы (инструментарий) – способы их восполнения с учетом современных реалий. | [
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785 | Методологическая основа исследования: правовой прогностический подход; общефилософские методы диалектики и логики; общенаучные методы классификации, анализа, синтеза, системный метод; правовые методы: историко-правовой, сравнительно–правовой, метод толкования правовых норм. | [
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786 | Теоретическая значимость и новизна: предложена комплексная концепция пробелов в международном праве как составной части российской международно-правовой доктрины. | [
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787 | Практическая значимость: результаты диссертационного исследования могут быть полезны для органов российского государственного аппарата, включая МИД РФ, другие министерства и ведомства, Аппарат Правительства РФ, Федеральное Собрание, а также в научной и образовательной сферах в части международно-правовых наук/ дисциплин. | [
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788 | В настоящее время активно ведутся исследования средств связности текста, которые могут выражать разнообразные отношения между частями текста. | [
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789 | Настоящая диссертационная работа посвящена рассмотрению дискурсивных единиц «более того», «мало того», «мало этого», «мало того что». | [
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790 | В центре внимания находятся синтаксические употребления исследуемых единиц. | [
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791 | В результате анализа отмечаются их синтаксические функции, сферы действия и особенности структуры исследуемых единиц, а также представляются материалы для подтверждения особенности их функционирования в синтаксическом аспекте. | [
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792 | На основании выполненных соискателем исследований: - определена диагностическая информативность ультразвукового исследования в определении гетеротопий различной локализации; - определено место 3D-реконструкции в диагностике «малых форм» эндометриоза; - изучены изменения биомаркеров у женщин с эндометриоз-ассоциированным бесплодием в зависимости от фазы менструального цикла и в сопоставлении с ультразвуковыми данными; - оценены изменения содержания биомаркеров в зависимости от вида проведенного лечения и ультразвуковой картины; - разработан и внедрен алгоритм неинвазивной диагностики «малых форм» эндометриоза у женщин с бесплодием, основанный на ультразвуковых критериях в сочетании с использованием панели биомаркеров. | [
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793 | Теоретическая значимость исследования обоснована тем, что проведенные исследования позволили создать основу для разработки инновационных подходов к диагностике «малых форм» наружного эндометриоза. | [
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] |
794 | Обоснован комплексный подход к выявлению и дифференциальной диагностике начальных стадий эндометриоза. | [
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] |
795 | Показано, что высокая диагностическая информативность достигается за счет комплексного применения предложенной панели биомаркеров (IL-1?, IL-6, СА-125, НЕ4 и индекса ROMA) и ультразвуковой визуализации с использованием серой шкалы, допплерометрии и 3D-реконструкции в зависимости от предполагаемого расположения патологического очага. | [
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796 | Значение полученных соискателем результатов исследования для практики подтверждается тем, что для женщин с эндометриоз-ассоциированным бесплодием разработаны и внедрены критерии неинвазивной диагностики, основанные на результатах ультразвукового исследования в сочетании с оценкой изменений биологических маркеров воспаления. | [
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797 | На основании этих показателей возможна оценка качества проводимого лечения и прогноз наступления беременности. | [
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798 | Разработанные компьютерные программы – «Программа для неинвазивной диагностики и оценки лечения малых форм эндометриоза у женщин с бесплодием» и «Программа для контроля организации неинвазивных методов ультразвуковой диагностики в медицине» используются врачами УЗД, акушерами-гинекологами и репродуктологами для дифференциальной диагностики и оценки терапии бесплодия, ассоциированного с начальными стадиями наружного эндометриоза. | [
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799 | Результаты диссертационного исследования внедрены в клиническую практику Государственного бюджетного учреждения здравоохранения «Самарский областной медицинский центр «Династия», Государственного бюджетного учреждения здравоохранения Самарской области «Самарская городская поликлиника № 3», Частного учреждения здравоохранения «Клиническая больница «РЖД – Медицина» г. Самары». | [
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