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Nirsevimab builds on the efficacy offered by the current standard of care, Synagis (palivizumab), which is indicated for high-risk infants and requires up to five monthly injections to cover a typical RSV season.

imposition or increase of gaming duty in markets in which the Group has customers.

We created a common framework to support operating companies with preparing, communicating, conducting and wrapping up the sessions.

Service disruptions or degradations could prevent access to our online services and account information, compromise or limit access to company or customer data, impede or prevent transaction processing and financial reporting, and lead to regulatory investigations and fines, increased regulatory oversight and litigation (including class action litigation).

At the beginning of the year, the Committee reviews and approves the audit plans of the external auditor as well as Global Audit.

Responsibilities of the Supervisory Board Audit Committee include oversight of external reporting, compliance with internal and external auditor recommendations on BaBW reporting, and risk management.

If we are unable to obtain, defend and enforce IP that protects our products, we may experience accelerated and intensified competition from third-parties.

Our information and cyber security program is designed to protect the confidentiality, integrity, and availability of information and information systems from unauthorized access, use, disclosure, disruption, modification, or destruction.

In addition to the Board of Directors, the Senior Executive Team, or SET, is the body through which the CEO exercises the authority delegated to him by the Board.

Responsible sales and marketing, see page > Anti-bribery and anti-corruption, see page 37.

transition risks, emerging from national and global policy responses to the climate crisis (such as regulatory changes, taxes and levies, etc) and the transition to a sustainable climate model (such as changes in energy availability and mix, disruptions to the company’s own or partner business models, and reduced availability of unsustainable components or materials).

the strict priority of creditor claims in limited circumstances, the use of an administrative claims procedure to determine creditor claims (as opposed to the judicial procedure used in bankruptcy proceedings), and the right of the FDIC to transfer claims to a “bridge” entity.

Compliance with financial, non-financial and other reporting requirements.

We issue preferred shares to help address a portion of the Tier requirements in excess of common equity requirements.

Fees for tax services include tax compliance and tax advice.

Any impairment loss of a revalued asset is treated as a revaluation decrease in accordance with that other Standard.

I am grateful for the resilience and agility of our people as we continued to navigate through the crisis, while building the future.

The principles would apply to OCC regulated institutions with more than $ provide a high-level framework for the safe and sound management of exposures to climate-related financial risks consistent with existing OCC rules and guidance.

Ethics and compliance Anti-bribery and corruption We operate in parts of the world where bribery and corruption present a high risk.

Markets need to be prepared to respond and adapt to these changes in a timely manner to prevent restrictions in all areas of the value chain and significant costs to ensure compliance.

We also conduct anti-bribery compliance audits on selected suppliers to assess their conformance with our anti-bribery and corruption contractual requirements.

In a ruling issued on February confirmed the validity of the application of the fee caps and other provisions in circumstances where three-party networks issue cards with a cobrand partner or through an agent, although the ruling provided only limited guidance as to when or how the provisions might apply in such circumstances and remains subject to differing interpretations by regulators and participants in cobrand arrangements.

In a member of the Executive Board had a conflict of interest that was of material significance.

As outlined in the Chair’s Statement of this Annual Report, in March 2022 (post the year-end), the firm received a sanction from the GB regulator (UKGC), reflecting historic failings of former safer gambling and antimoney laundering policies, procedures and controls in the UK.

The Company may offer compensation to buy out awards or other lost compensation which the candidate held prior to joining the firm, but which lapsed upon leaving their previous employer.

Action necessary to change the rights of shareholders In order to vary the rights attached to any class of shares, the consent in writing of the holders of three quarters in nominal value of the issued shares of that class or the sanction of a special resolution passed at a general meeting of such holders is required.

The three key growth drivers for our businesses are: resource efficiency through electrification and automation, where we are global leaders, occupying number are accountable for growth and decision-making has been moved closer to the market; and the acceleration of environmental, social and governance (ESG) drivers for energy efficiency and automation.

We follow the UN Guiding Principles on Business and Human Rights and our Human Rights policy, Supplier Code and due diligence process guide us to understand, avoid and address our human rights related risks.

Risk assessment outcomes are aggregated at a global level and serve as basis for determining the firm’s risk exposure and risk management priorities by the Risk Committee.

of the German Stock Corporation Act, in which the company has a direct or indirect stake of at least option obligations, or shares are tendered and no other forms of fulfilment are used.

As the pandemic continued, we made the decision to increase investments to drive customer acquisition, engagement and retention.

The programme allows the firm N.V. to issue Notes for a total amount of up to €20 billion.

Our activities require high levels of investment and are sometimes conducted in challenging environments such as those prone to natural disasters and extreme weather, which heightens the risks of technical integrity failure.

the firm is constantly looking to enhance its internal compliance system and resilience to adapt to changes in the legal environment.

The statement contained in this section explains the key features of the Company’s governance structure and compliance with the Code.

Conflict of Interest The Articles of Association and the Regulations of the Supervisory Board prescribe how to deal with (apparent) conflicts of interest between the Company and members of the Supervisory Board.

This reinforces the importance of the integrity of the Group’s Financial Statements, the reliability of the accounting records on which they are based and the robustness of the relevant controls and processes.

We may not succeed in doing so, particularly in the current competitive and regulatory environment.

Since million shares have been repurchased to offset the expected full year dilution from the vesting of awards under employee share schemes in 2022 and an additional $1.0 billion shares have been repurchased up to 1 March 2022, both including fees and stamp duty.

We are incredibly proud of our culture and people are at the heart of our business.

2021 has continued to be volatile, with a high degree of uncertainty driven by the COVID-19 crisis.

the firm also held the voting rights at general meetings of shareholders conferred by its 19.75% stake in Rosneft.

A fair wage is often higher than the minimum wage and should be sufficient for a decent standard of living, covering the basic needs of the employee and him/her family - from food, housing and education to healthcare, transportation and some discretionary income and savings.

Continuous improvement is achieved through global compliance monitoring and systematic gap-closing.

Fund the growth We are structurally addressing our cost base and building a cost-conscious culture to support our growth ambitions, offset inflationary pressures, restore our profitability and thereafter gear our business to deliver operating leverage consistently.

Directors have a duty not to put themselves in a position in which their duties to the company and their personal interests might conflict and also are under a duty to disclose any personal interest in any contract or arrangement with the company or any of its subsidiaries.

We have established and continue to maintain policies and a governance framework to comply with applicable privacy, data protection, data governance and information and cyber security laws and requirements, meet evolving customer and industry expectations and support and enable business innovation and growth.

and materiality We defined our Brew a Better World priorities through open conversations and engagement with our stakeholders – both internal and external.

It sets out the standards and requirements which govern key risk management activities such as inspection, maintenance, testing, business continuity and crisis response planning and competency development.

Career summary Tushar Morzaria is a chartered accountant with over years of strategic financial management, investment banking, operational and regulatory relations experience.

These reviews consider several factors known to affect compensation, including role, level, tenure, performance and geography.

The elements of a diverse composition of the Supervisory Board are laid down in the Diversity Policy of the Supervisory Board, Executive Board and Executive Team as per best practice provision 8 December 2016 (the ‘Code’).

Our business is subject to the risk of litigation involving current and former employees, clients, alliance partners, subcontractors, suppliers, competitors, shareholders, government agencies or others through private actions, class actions, whistleblower claims, administrative proceedings, regulatory actions or other litigation.

In order to comply with competition law requirements, the firm was obligated to sell the grid connection for the Rampion offshore wind farm, which had been fully consolidated since 1 April 2021.

COMPLIANCE RISK MANAGEMENT PROCESS We define compliance risk as the risk of legal or reputational harm, fines, monetary penalties and payment of damages or other forms of sanction as a result of non-compliance with applicable laws and/or regulations, internal policies and procedures and related practices, or ethical standards.

and Gaming Council (BGC), looking at the issue of affordability and helping to find a workable regulatory response.

Units (countries, sites, suppliers, brands, etc.) which, for specific reasons, received formal derogations for compliance with commitments are excluded from the indicator scope in consolidation.

In these countries, increases in excise duties are not always (fully) passed on to customers and the firm cannot, or can only partly, reclaim the excise duty in the case products are eventually not sold to customers.

This is also where we report our investments in Dutch nuclear power plant operator EPZ (which holds a 33 % stake in uranium enrichment specialist Urenco.

Total number and nature of incidents of corruption confirmed during the current year, related to this year.

The framework includes risk-based third-party due diligence and internal and external awareness and training.

The S&SC also received regular reports from the CEO and SVP S&OR on operational risk, including regular reports prepared on the group’s health, safety, security and environmental performance and operational integrity.

We look at our water impacts contextually, including internal water usage and wastewater management, and external promotion of water security beyond our brewery walls.

• Receivables and payables are stated with the amount of customs duty or sales tax included.

the firm has a minority stake in Hitachi Energy Ltd (Hitachi Energy), the holding company of the firm’s former power grids business.

Our equity capital and funding strategies are designed, among other things, to maintain appropriate and stable unsecured debt ratings from the major credit rating agencies: Moody’s Investor Services (Moody’s), Standard & Poor’s (S&P) and Fitch Ratings (Fitch).

Through unlocking the full potential of our people and organisation, we are on a journey to create a workplace and culture that attracts, develops and retains talent who embody our new purpose and values.

No gain or loss is recognised in profit or loss on the purchase, sale, issue or cancellation of the Group’s own equity instruments.

In December Medicines Agency’s Committee for Medicinal Products recommended the approval of Saphnelo in the EU as an add-on therapy for the treatment of adult patients with moderate to severe, active autoantibody-positive SLE, despite receiving standard therapy.

Discounts are accounted for as a reduction of revenue.

The UK GDPR, which became effective in January fine structure of the GDPR.

Global Compliance helps the Group achieve its strategic priorities by doing business the right way, with integrity and high ethical standards.

The Ukraine crisis, in particular, is currently associated with risks.

The global risk oversight team oversees the policies, strategies, frameworks, models, processes and capabilities deployed by the first line teams and provides challenges and independent assessments on how the first line of defense is managing risks.

We assess any exposure to bribery and corruption risk when working with suppliers and business partners.

The federal banking regulators’ guidance on sound incentive compensation practices sets forth three key principles for incentive compensation arrangements that are designed to help ensure that incentive compensation plans do not encourage imprudent risk-taking and are consistent with the safety and soundness of banking organizations.

Failures or delays in the quality and execution of the Group’s commercial strategies. – Scenario pricing, higher than anticipated competition and other commercial headwinds result in lower than anticipated growth rates for our medicines. – Scenario 2 – A significant incident leads to reputational damage in a key market resulting in an ongoing 10% revenue reduction in this market.

Our business activities could be disrupted if we do not respond, or are perceived not to respond, in an appropriate manner to any major crisis or if we are not able to restore or replace critical operational capacity.

To fund this, we are structurally addressing our cost base and building a cost-conscious culture.

Salaries and employee benefits expense increased, primarily driven by higher compensation.

It employs a systematic and disciplined approach to evaluate and improve the organisation’s governance and risk management process including reliability of information, compliance with laws, regulations and procedures, and efficient and effective use of resources.

In addition, as our practice is to include uncollectible interest and/or fees as part of our total provision for credit losses, a net write-off rate including principal, interest and/or fees is also presented.

In identifying potential risks of material misstatement due to fraud and non-compliance with laws and regulations, we evaluated the Company's risk assessment, had inquiries with management, those charged with governance and others within the group, including but not limited to, in-house legal teams, compliance officers, internal audit and financial reporting teams.

The Company competes primarily on the basis of differentiating its brands from competition through: product, higher quality and increased newness; brand voice, amplifying and consolidating brand messaging; and experience, investing in immersive, participatory omnichannel shopping environments.

We define information and cyber security risk as the risk that a security incident could impact the confidentiality, integrity or availability of the firm customer, colleague or proprietary information.

We are subject to significant supervision and regulation, and an increasingly stringent enforcement environment, with respect to compliance with anti-money laundering (AML), sanctions and anti-corruption laws and regulations in the United States and in other jurisdictions in which we operate.

Relevance to strategy Human capital is important to online gaming businesses, and online businesses generally, and competition for highly-qualified personnel is intense in locations in which the Group is based.

– (Functional) Updates in respect of Global Procurement, Global Treasury & Insurance and Global Tax, Pensions, Business Conduct and Global Legal Affairs, as well as Risk Management.

Established in Board is responsible for oversight of BaBW strategy development and delivery.

This potential Regulatory Authority action could therefore cause substantial damage to the Group’s business or prospects.

Trade and other receivables are derecognised by the firm when substantially all risks and rewards are transferred or if the firm does not retain control over the receivables.

Despite the challenges, this year our EverGreen strategy gained momentum and we made a big step towards recovering our results to pre-pandemic levels with the strength of the firm®, the scaling of new innovations and the significant savings we unlocked by simplifying and right-sizing our cost base.

including through enforcement actions, legislation and regulations to change certain practices or pricing of card issuers, merchant acquirers and payment networks, and, in some cases, to establish broad and ongoing regulatory oversight regimes for payment systems.

Made for the Future is built around three key pillars: Made to Play Safely (focused on safer gambling), Made Together (focused on on managing the firm’s impact on the environment), all of which are underpinned by a robust Governance structure.

Factors including a lack of, or insufficient development and application of, policies, regulations and frameworks that support low carbon businesses; insufficient consumer demand for our low carbon offering; strong competition in the market; or the insufficiently rapid development of supporting technologies and supply chains for low carbon energies could restrict growth of, or returns from, our transition businesses.

There is an organisational structure with clearly drawn lines of accountability and delegation of authority.

First and most important is the quality and behaviour of operational management, the first line of defence.

the firm performs a country by country analysis to assess whether the excise duty is sales-related or effectively a production tax.

Committed bank facilities are credit facilities on which a commitment fee is paid as compensation for the bank’s requirement to reserve capital.

COMPETITION The Company operates in a rapidly evolving and highly competitive retail business environment.