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W1992254126 | Expression of the c-fos-monomeric red fluorescent protein 1 fusion gene in the spinal cord and the hypothalamic paraventricular nucleus in transgenic rats after nociceptive stimulation | We generated transgenic rats expressing the c-fos and monomeric red fluorescent protein 1 (mRFP1) fusion gene in the central nervous system after adequate stimulation. In the present study, the time-course of the induction patterns of mRFP1 fluorescence in the spinal cord and the paraventricular nucleus (PVN) was compared with that of Fos-like immunoreactivity (LI) within 24 h after subcutaneous (s.c.) injection of 0.9% saline and 5% formalin in both hind paws. Control rats were not treated. In the control and saline/formalin injected rats, scattered mRFP1 fluorescence in the spinal cord and the PVN was observed at 0 min, though there was little Fos-LI in the same region. The mRFP1 fluorescence in the spinal cord and the PVN was increased at 3h after formalin. On the other hand, the changes of Fos-LI in the spinal cord and the PVN were relatively shorter than those of the mRFP1 fluorescence after formalin. These results suggest that the c-fos-mRFP1 fusion gene expression is slightly upregulated in normal conditions and nociceptive stimulation-induced induction of the fusion gene may be maintained longer than the endogenous c-fos gene expression in the spinal cord and the PVN. Next, nocifensive behavior and mRFP1 fluorescence and Fos-LI in the spinal cord and the PVN after s.c. injection of formalin, 4α-phorbol 12,13-didecanoate (4α-PDD) and saline were compared. Although the 4α-PDD injected rats seldom displayed nocifensive behaviors like s.c. saline injection, 4α-PDD injection caused mRFP1 fluorescence and Fos-LI significantly in the spinal cord and the PVN unlike s.c. saline injection. | publication |
US 2017/0048635 W | CORD LOCK | A cord lock includes various components used to slidably adjust a length of cord. The cord lock may include a first cord-clamp bar and a second cord-clamp bar that are movably coupled to each other, to allow control of frictional resistance on a cord threaded through various apertures and cord-receiving channels of the cord lock. The cord lock may be incorporated into an article such that it is at least partially concealed within an article layer. | patent |
W21371338 | Obesity and Exercise-Induced Airway Obstruction Measured by Impulse Oscillometry | Background: the efficacy of impulse oscillometry (IOS) as an effortless technique for detection of different aspects of airway resistance in non-athlete obese men has not been fully appreciated. The objective was to evaluate concomitant airway responses induced by obesity and exercise pre and post an exercise bronchial provocation test and to recognize whether IOS variables relate to spirometry variables. Settings: 15 obese (BMI ≥ 35) and 13 lean (BMI ≤ 25) young men were enrolled in the study. Spirometry and IOS parameters were performed at baseline and for 20 mints after a treadmill exercise challenge of 8 minutes at 5-mint intervals. Heart rate (200 - 0.5 × age) was documented to verify exercise intensity. Obese subjects were screened based on the criteria of having a well-preserved FEV1/FVC ratio. Results: Correlations were found between resting FEV1 and IOS except for Ax (area of reactance) in the obese group. R5 at 5-min post-challenge was well correlated with the percent decrease in FEV1. Spirometry revealed significant differences in post-challenge percent changes only at 5-min after exercise; however, IOS identified differences in respiratory resistance at 5 and 10-min post-challenge time points. In obese group, sensitivity for X and R5 was 86% and 78%, respectively. Conclusions: obesity had no additive effects on proximal airway changes induced by exercise; however, IOS detected a difference in degree of small peripheral airway response to exercise in obese group, suggesting that IOS is a more sensitive measure of exercise-induced airway narrowing. IOS parameters, especially Ax may be more sensitive for detection of pulmonary function in obese people. | publication |
Q82020 | Ingresso nel mercato NewConnect e supporto consultivo per Massmedica sp. z o.o. nella raccolta di capitali e investitori | Sa 42799(2015/X) Regolamento CE n. 651/2014 Articolo 18 Aiuti per servizi di consulenza alle PMI L'obiettivo del progetto è quello di sostenere il richiedente nell'accesso al mercato dei capitali, nonché di attivare il mercato degli investitori creando le condizioni per avviare la cooperazione degli investitori con la Società. La ricorrente assume l'acquisizione di non più di 4 milioni di PLN. Queste misure consentiranno un significativo sviluppo e ampliamento dell'offerta aziendale con un prodotto innovativo per il ripristino permanente delle strutture del collagene. Il progetto prevede l'acquisizione da parte della Società di servizi di consulenza forniti da Prometeia Capital sp. z o.o. ("Adviser"), relativi alla preparazione della documentazione al fine di attrarre investitori e ricapitalizzare la Società. Il consulente preparerà i seguenti documenti: Due Dilligence Report, valutazione della società, documento di offerta, teaser di investimento, presentazione degli investitori, documento informativo, politica informativa, procedura di circolazione delle informazioni riservate. La documentazione sarà utilizzata per emettere e vendere azioni. Il consulente condurrà uno studio della Società e preparerà un Rapporto Due Dilligence per determinare la situazione finanziaria e formale-legale della Società. La valutazione della Società sarà fornita agli investitori, giustificando il prezzo proposto delle azioni e l'Investment Teaser, presentando concise informazioni sulla Società. Gli investitori interessati riceveranno un documento di offerta contenente informazioni dettagliate sulla Società, sui titoli e sui meccanismi di offerta. La presentazione dell'investitore sarà presentata durante gli incontri con gli investitori. Il documento informativo sarà redatto al fine di richiedere l'introduzione di azioni alla negoziazione sul mercato NewConnect. Saranno inoltre predisposte la Procedura di circolazione delle informazioni riservate e la Politica Informatica della Società, specificando le regole di circolazione e presentazione delle informazioni, in particolare per la necessità per la Società di adempiere ai propri obblighi di informazione. Tutti i documenti sono necessari per l'attuazione efficiente ed efficace del progetto. A causa della natura innovativa del progetto | project/regional |
Q4762919 | FRESIA JOINT STOCK COMPANY IN THE ACRONYM “FRESIA S.P.A.” | THE INVESTMENT PROGRAM IS PARTLY ALREADY REALISED AND CONSISTS OF THE PURCHASE OF TWO LATEST GENERATION CNC MACHINE TOOLS AND THE PURCHASE OF A SERIES OF COMPONENTS FOR MEASURING MACHINERY. AS FAR AS THE MEASURING MACHINERY IS CONCERNED, A THREE-AXIS CONTROL SYSTEM WITH ITS CONTROL BUTTON, A FIVE-AXIS HEAD, A SOFTWARE WITH A SCANNER SYSTEM ON FIVE AXES HAS BEEN PURCHASED. THE COST OF SUCH ACQUISITIONS AMOUNTED TO ABOUT 38 THOUSAND. IT IS PLANNED TO BUY A CNC LATHE FOR AN AMOUNT EQUAL TO 236 THOUSAND ‘TO WHICH YOU WILL GO’ TO ADD A HORIZONTAL MACHINING CENTER TO CNC FOR AN AMOUNT EQUAL TO MORE THAN 900 THOUSAND’. FRESIA HAS DECIDED TO LAUNCH THIS IMPORTANT INVESTMENT PLAN IN ORDER TO MEET THE PRODUCTION NEEDS RECORDED IN RECENT YEARS THAT HAVE SEEN THE INCREASE IN TURNOVER IN AN EXCEPTIONAL WAY, ESPECIALLY AS REGARDS THE EXPORT QUOTA. IN ORDER TO SUCCEED IN | project/regional |
W4229064808 | INFLUÊCIA NUTRICIONAL NO ESTADO EMOCIONAL DE PACIENTES HIV+ EM TRATAMENTO ANTIRETROVIRAL NO HOSPITAL DISTRITAL DA MAGANJA DA COSTA | O presente artigo cujo tema é Influência nutricional no Estado Emocional de Pacientes HIV+ em Tratamento Antiretroviral, trata-se de uma pesquisa que teve lugar no Hospital Distrital da Maganja da Costa. A pesquisa centrou-se em Analisar a influência nutricional no estado emocional dos pacientes HIV+ em terapia Antiretroviral, atendidos no Hospital Distrital de Maganja da Costa. A pesquisa foi realizada com vista a avaliar o estado emocional de pacientes atendidos no Hospital Distrital da Maganja da Costa, envolvendo um total de 500 pacientes, portadores de HIV, escolhidos de forma Aleatória Simples. Os dados antropométricos foram colectados por técnicos nutricionistas, psicólogos e clínicos, previamente treinados para a análise do estado nutricional, emocional, e clínico geral desses pacientes. Com esta pesquisa, espera-se conhecer o estado emocional dos pacientes com HIV em tratamento ambulatório no Hospital Distrital da Maganja da Costa com vista a melhoria na adesão e retenção ao tratamento Antiretroviral e, contribuir para a redução da prevalência do HIV no Distrito da Maganja da Costa em particular e consequentemente em Moçambique no geral, com a iniciativa testar, iniciar, reduzir a carga viral e automaticamente reduzir novas infecções | publication |
629492 | Rethinking widowhood: women, loss, and liberation in nineteenth-century musical culture | Whereas past histories of European music have been presented largely in terms of an all-male endeavour, this interdisciplinary project will take the lived experiences of widows as an impetus for developing a new kind of historiography, framed in terms of the history of emotions, that restores women’s individual agency and artistic integrity to the music-historical record. The research will introduce a paradigm shift to gender studies in musicology in two particular respects: first, by rethinking the ways in which widowhood proved to be a catalyst for creative endeavour that was a product both of loss and of a sense of liberation; and secondly, by engaging with widowhood as a lens through which to reconsider the contributions of women who have been overlooked in the dominant narratives of music history. In doing so, the project will address major European policy objectives, particularly those recommended by the United Nations Sustainable Development Goals 5 and 10, to promote gender equality and to reduce social inequalities in all aspects of society. | project/european |
984469 | Launching first large-scale organic seaweed-to-food cultivation and processing in eu | The SeaBest project will be the first to close the circle from seaweed spore to a high quality organic food product using a large-scale and cost-competitive approach in Europe. The project will allow 1,000-14,000t of seaweed to be produced in Europe at up to 56% less cost compared to current practises. Our project will satisfy the high unmet demand of the global market for cultivated organic seaweed worth €9.3bn and of the European organic food market worth €30 billion in 2015. For the first time ever, we will enable low-cost high-volume organic seaweed to be produced in Europe, fully traceable, foodgrade certified and ready for use as an ingredient on its own or in a multitude of products. We are already in talks with over 15 EU food producers and we have Letters of Intent documenting demand for over 3,200t just from 5 large clients who are awaiting the ability to purchase organic European seaweed on a large-scale - so that they can pursue catering to dominant global food outlets such as IKEA and Schouten. We have performed a Phase 1 Feasibility Study funded by Innovation Norway (VIDAN - 2014/104777) that validated our pilot plant at TRL 7 and commercial viability. Over €14 million has been invested in our unique and game-changing solution since 2009 including SEAWEED-STAR Eurostars (#6027) project that verified our offshore farming technology. We are part of the H2020-BG-2016-1 project GENIALG aiming to boost the EU Blue Biotechnology Economy (BBE) by increasing the sustainable production of EU seaweed. Phase 2 funding will allow us to reach full commercial viability through technology maturation, piloting and market maturation activities. SeaBest will generate 30 new FTEs within SES and another 36 in our production partners, and we estimate an accumulated €76.5m in revenues after 5 years. By mechanising seaweed farming and reducing production costs, SeaBest will also open the way to new markets in bioenergy, biopharmaceuticals and animal nutrition. | project/european |
FR 8500394 A | PANNEAU DE CONSTRUCTION POUR LA PROTECTION DE LOCAUX BANCAIRES OU ANALOGUES | <P>LA PRESENTE INVENTION CONCERNE UN PANNEAU DE CONSTRUCTION.</P><P>CE PANNEAU COMPORTE DEUX PLAQUES EXTERNES 1, 2 ENTRE LESQUELLES SE TROUVE UN MATERIAU DE REMPLISSAGE CONSTITUE NOTAMMENT PAR DES ELEMENTS ALLONGES 16, 19 QUI SONT CONSTITUES PAR DES BARRES TORSADEES ET QUI SONT DISPOSES AVEC JEU DANS DES CHAMBRES 15 DE FACON A POUVOIR SE DEPLACER DANS UN PLAN VERTICAL, HORIZONTAL OU EN ROTATION, SOUS L'EFFET D'UN OUTIL DE PERCAGE.</P><P>LE PANNEAU DE L'INVENTION S'APPLIQUE PAR EXEMPLE A LA PROTECTION DES MURS DE LOCAUX BANCAIRES.</P> | patent |
174890 | Profiling and targeting news readers – implications for the democratic role of the digital media, user rights and public information policy | In the digital media environment, user attention is scarce and competition for ‘eyeballs’ is fierce. Profiling and targeting readers with customised news and advertisements that match their individual interests is widely seen as a solution. The personalization of news media content enables new financing strategies and means to capture the audience’s attention. But personalisation is also part of a more fundamental paradigm shift in the media’s role from public interest intermediary to personal information coach. This research will answer critical questions about the implications for individual users and contribute to a new normative theory of the role of personalised media in a democratic society.
To do so, this project integrates legal research, communication sciences and political sciences, undertakes comparative, normative and evidence-based research, and carries out experiments, interviews and a survey. Two communication science postdocs will conduct empirical research into user concerns, the conditions that affect users’ acceptance of media personalisation (postdoc 1), and how personalisation affects journalistic practices and ethics (postdoc 2). Informed by these insights, two PhD students will scrutinise the legal framework and answer important questions about the legal protection of the public’s trust in editorial integrity (PhD 1) and autonomous, non-discriminatory information access (PhD 2). The PI will develop a normative framework of personalised media, based on the empirical research and political theories about the democratic role of the media. This responds to the criticism that existing theories are increasingly disconnected from the realities of digital media and their distinct contribution to democratic and participatory processes. The project will explore the potential of personalisation to expose citizens to more relevant or diverse content, thus reversing widespread concerns about information overload, filter bubbles and selective exposure. | project/european |
Q81599 | Garagem modular e construção econômica para automontagem pelo utente — um sistema feito, embalado e montado em tecnologia ambientalmente amigável | «Numer_reference_aid_programa: SA.42799(2015/X), aid_de_minimis: Artigo 42.º do Regulamento do Ministro das Infraestruturas e do Desenvolvimento, de 10 de julho de 2015, relativo à concessão de assistência financeira pela Agência polaca para o Desenvolvimento Empresarial no âmbito do Programa Operacional Crescimento Inteligente 2014-2020 "O objeto do projeto é o desenvolvimento, pela unidade científica, de um novo produto — um edifício moderno em garagem e economia, feito de elementos modulares, de madeira, à base de madeira e outros elementos respeitadores do ambiente, preparado para a automontagem pelo utilizador final e o desenvolvimento de tecnologias de embalagem eficientes, permitindo minimizar os custos de transporte, graças à dimensão ótima, ao peso da expedição e à utilização de parte da embalagem como parte de uma garagem. O principal tema do trabalho de pesquisa é o design de conectores de módulos individuais, garantindo a montagem mecânica realizada de forma independente pelos utentes finais. No âmbito do projeto, a unidade realizará trabalhos de investigação e execução, pelo que desenvolverá: 1. projeto arquitetônico e de construção conceitual para a construção de um edifício modular da garagem; 2. projeto tecnológico e da oficina de módulos e conectores com visualização; 3. faça conectores protótipos de módulos de construção de garagem para garantir a segurança da estrutura e segurança de uso e realizar seus testes; 4. fornecer um modelo de apresentação para o edifício da garagem; 5. desenvolve tecnologia de embalagem eficiente para minimizar os custos de transporte e usar parte da embalagem como parte de uma instalação de garagem; 6. conduzir pesquisas ao utente final sobre a avaliação da solução desenvolvida. O resultado mais importante do projeto, como um todo, será a implementação de um novo produto na atividade empresarial da Companhia, o que contribuirá para ampliar os mercados de vendas e ofertas da Companhia, aumentando suas receitas. O novo produto é e | project/regional |
W2127522925 | Event Algebra for Transition Systems Composition - Application to Timed Automata | Formal specification languages have a lot of notions in common. They all introduce entities usually called processes, offer similar operators, and most importantly define their operational semantics based on labeled transition systems (LTS). However, each language defines specific synchronizing and/or memory structures. For instance, in CSP, the synchronization is defined between identical events, while in CCS and in synchronization vectors-based views it is defined respectively between complementary events or between possibly different events. In this paper, we aim at capturing some similarities of specification languages by defining a label-based composition formal framework. Firstly, we define a high-level synchronization mechanism in the form of an abstract label structure. We then couple this label structure with several compositional operations and properties. Secondly, we introduce an LTS-based behavioral framework and define a unique LTS composition operator which is reused to define syntactic composition of extended transition systems and a compositional semantics. | publication |
W4224226909 | Inclusión financiera en los países de la zona euro: una oportunidad para aumentar el bienestar social | El desarrollo de la sociedad y la mejora del bienestar social han generado un cambio de paradigma sobre el papel que juegan las empresas en la economía nacional y mundial. Las empresas ya no centran sus operaciones exclusivamente en la maximización de las ganancias para los propietarios o inversores, sino también en aumentar las ganancias y el bienestar social para todo tipo de stakeholders. En este escenario, los clientes de las instituciones financieras se han convertido en una fuerza de desarrollo económico, social y cultural, especialmente después de la crisis financiera iniciada en 2008, que ha destacado la fragilidad del sistema financiero internacional, la existencia de una fuerte asimetría de información entre entidades de crédito y consumidores de los servicios financieros, además de la necesidad de fortalecer la confianza de estos últimos para incrementar su grado de inclusión financiera. Por ello, esta contribución ofrece un análisis de las estadísticas propuestas por el Global Findex, publicadas por el Banco Mundial, para los países de la Eurozona y sugiere la necesidad de incrementar el nivel de inclusión financiera de los consumidores en cuestión. La inclusión financiera es una prioridad clave entre los Objetivos de Desarrollo Sostenible de las Naciones Unidas, ya que es considerada como un impulso para aumentar la resiliencia y apoyar la mejora de la calidad de vida de los consumidores, aprovechando las oportunidades económicas existentes. Esta investigación destaca brevemente los beneficios de promover la inclusión financiera para garantizar un crecimiento económico sostenible y fortalecer la inclusión digital. Las medidas propuestas pretenden cambiar la postura de las entidades de crédito que deben centrarse en los grupos vulnerables (jóvenes y mujeres) para proporcionarles productos y servicios financieros atractivos y convenientes. | publication |
171622 | Interactive charging | The INteractive CHarging (INCH) project will introduce the next-generation charging station for electric vehicles (EVs), named Etrel Smartcharger. It will enable charging of an increasing number of EVs in a smart and sustainable manner, which is the only way to optimise energy use in transport and reduce related greenhouse gas emissions. In the long term, it will not be possible to use EVs without using solutions such as the Smartcharger. The Smartcharger is a new version of Etrel's current product generation, designed as a low-voltage AC charging station for use at homes, offices, and car parks. It will bring down the cost of smart charging infrastructure deployment where it matters the most (more than 90 % of charging takes place at home or at work). At the same time, it will bring the charging network to a new level, allowing each and every connected car to adjust its consumption to the needs of the energy grid.
Market adoption of the Smartcharger will be driven mostly by EV drivers who require an interactive solution that can automatically charge their car in the desired time without overloading the circuit. The Smartcharger will allow each EV user to save 140 EUR per year in charging costs and will return the investment in 3-4 years, roughly a third of its lifetime. Users will be able to share control over their charging with power companies in exchange for financial compensation. This will give the power companies an option to control EV charging load, in order to reduce it in time of peak demand or use the batteries as a reservoir for electricity from renewable sources at times of high production. With an additional investment of 1.322.000 EUR, an estimated 67M EUR of profits and 65 new jobs within the company are expected over the course of 10 years after the end of the project. The INCH project will also present an enabling technology for the integration of EV charging into European smart grids and for the provision of new services in electromobility. | project/european |
W1990919222 | Semi-automatic extraction and exploitation of hierarchical pipeline parallelism using profiling information | In recent years multi-core computer systems have left the realm of high-performance computing and virtually all of today's desktop computers and embedded computing systems are equipped with several processing cores. Still, no single parallel programming model has found widespread support and parallel programming remains an art for the majority of application programmers. In addition, there exists a plethora of sequential legacy applications for which automatic parallelization is the only hope to benefit from the increased processing power of modern multi-core systems. In the past automatic parallelization largely focused on data parallelism. In this paper we present a novel approach to extracting and exploiting pipeline parallelism from sequential applications. We use profiling to overcome the limitations of static data and control flow analysis enabling more aggressive parallelization. Our approach is orthogonal to existing automatic parallelization approaches and additional data parallelism may be exploited in the individual pipeline stages. The key contribution of this paper is a whole-program representation that supports profiling, parallelism extraction and exploitation. We demonstrate how this enhances conventional pipeline parallelization by incorporating support for multi-level loops and pipeline stage replication in a uniform and automatic way. We have evaluated our methodology on a set of multimedia and stream processing benchmarks and demonstrate speedups of up to 4.7 on a eight-core Intel Xeon machine. | publication |
W2254021673 | Colonial Exhibitions under Salazar and Mussolini (1930-1940) | During the 1930s, Salazar‘s and Mussolini’s regimes set in motion intensive colonialist propaganda that was at work in particular in national exhibitions and the participation in international exhibitions. Even if the goals of the exhibitions differed –?economic and diplomatic objectives in the Antwerp (1930) and Paris (1931) international exhibitions and domestic political objectives for those in Porto (1934), Naples (1934, 1940) and Lisbon (1940)–? all of the exhibitions conveyed discourse and images that were typical of European colonialism between the wars. So the real specificity of these dictatorships’ colonial exhibitions is not to be sought in their attempt to reach a consensus on their colonial politics, but in an attempt to legitimize and consolidate the regimes. | publication |
GB 9201022 W | PHARMACEUTICAL COMPOSITIONS | Polysaccharides comprising at least 5 sialic acid residues per molecule and used to increase the circulation time, decrease the immunogenicity and/or increase the stability in vivo of pharmaceutically active compounds. The pharmaceutically active compound may be a foreign protein which is covalently bound to the polysaccharide. Alternatively the active compound may be associated with a drug delivery system (DDS), for instance a macro-molecular DDS or a particulate DDS, such as liposomes. The polysaccharide is usually a bacterial polysaccharide, e.g. a glycolipid or a derivative thereof, for instance polysaccharide B or E. Coli K1, N. meningitidis, Moraxella liquifaciens or Pasteurella aeroginosis, or K92 of E. Coli K92 strain. | patent |
Q2880300 | Office in security | it aims to adapt work organisation methods and relationships with customers and suppliers to the new conditions of physical detachment in the context of COVID-19, ensuring compliance with the established standards of the competent authorities in the company’s activity | project/regional |
W2055084238 | Topological characterization of the DnaA–oriC complex using single-molecule nanomanipuation | In most bacteria, the timing and synchrony of initiation of chromosomal replication are determined by the binding of the AAA(+) protein DnaA to a set of high- and low-affinity sites found within the origin of chromosomal replication (oriC). Despite the large amount of information on the role and regulation of DnaA, the actual structure of the DnaA-oriC complex and the mechanism by which it primes the origin for the initiation of replication remain unclear. In this study, we have performed magnetic tweezers experiments to investigate the structural properties of the DnaA-oriC complex. We show that the DnaA-ATP-oriC complex adopts a right-handed helical conformation involving a variable amount of DNA and protein whose features fit qualitatively as well as quantitatively with an existing model based on the crystal structure of a truncated DnaA tetramer obtained in the absence of DNA. We also investigate the topological effect of oriC's DNA unwinding element. | publication |
W2297009822 | Deux géologues français en Nouvelle-Hollande (Australie) Louis Depuch et Charles Bailly, membres de l’expédition Baudin (1801-1803) | L'expedition scientifique francaise, sous le commandement du capitaine Baudin, visita l'Australie entre 1801 et 1803. Parmi les savants, il y avait Louis Depuch (1774-1803) et Charles Bailly (1777-1844), les premiers geologues a etudier l geologie le long des cotes de ce continent. Leurs travaux en Australie furent fortement influences par les idees des celebres geologues Dolomieu (1750-1801)et Horace-Benedict de Saussure (1740-1790), qu'ils appliquerent aux roches de ce continent. Les ecrits de Depuch et Bailly, et ceux du zoologiste de l'expedition, Francois Peron, demontrent qu'ils acceptaient la theorie neptuniste pour l'origine des granites, qu'ils consideraient comme les roches les plus anciennes. Cependant ils refutaient cette theorie pour la formation des basaltes, qu'ils consideraient comme des produits des feux souterrains. Apres le retour de l'expedition en France, la collection geologique ne suscita pas un grand interet. La mort de Depuch a l'ile de France (ile Maurice) et la perte regrettable de son journal, ont contribue au manque d'appreciation de leurs decouvertes. Avec le temps, quelques-uns des savants europeens ont cependant reconnu l'importance des travaux de ces pionniers de la geologie australienne. | publication |
US 9825624 W | FUNGICIDAL COMPOSITIONS AND METHODS, AND COMPOUNDS AND METHODS FOR THE PREPARATION THEREOF | Fungicidal compositions and methods comprising acylated aminosalicylamides (AASA) described herein. Novel cyclic amines and 3-nitrosalicylamides, and their use as pesticides and in the preparation of the antifungal AASA compounds are also disclosed. | patent |
3737933 | Intense: particle physics experiments at the intensity frontier. a cooperative europe - united states effort. | INTENSE is a new European training network between universities, research centres and industries that will carry out an interdisciplinary research and training program for a cohort of 11 fellows. INTENSE promotes the collaboration among European and US researchers involved in the most important particle physics research projects at the high intensity frontier. The observation of neutrino oscillations established a picture consistent with the mixing of three neutrino flavours with three mass eigenstates and small mass differences. Experimental anomalies point to the presence of sterile neutrino states partecipating in the mixing and not coupling to fermions. Lepton mixings and massive neutrinos offer a gateway to deviations from the Standard Model in the lepton sector including Charged Lepton Flavour Violation (CLFV). The FNAL Short-Baseline Neutrino (SBN) program based on three almost identical liquid argon Time Project Chambers located along the Booster Neutrino Beam offers a compelling opportunity to resolve the anomalies and perform the most sensitive search of sterile neutrinos at the eV mass scale through appearance and disappearance oscillation searches. MicroBooNE, SBND, and Icarus will search for the oscillation signal by comparing the neutrino event spectra measured at different distances from the source. The FNAL SBN program and the CERN ProtoDUNE are a major step towards the global effort in realising the Deep Underground Neutrino Experiment (DUNE). Mu2e at FNAL will improve the sensitivity on the search for the CLFV neutrinoless, coherent conversion of muons into electrons in the field of a nucleus by for orders of magnitude. MEG-II and Mu3e at PSI will improve the sensitivity on other CLFV muon decays. INTENSE researchers have provided leading contributions and will take leading roles in detectors commissioning, data taking and analysis. These endeavours foster the development of cutting-edge technologies with spin-offs outside particle physics. | project/european |
W2059492132 | University–industry partnerships for the provision of R&D services | Abstract Technology Transfer Offices (TTOs) are the main institutions responsible for the establishment of university–industry partnerships. R&D contracts exemplify the indirect mechanisms through which enterprises and universities collaborate on a win–win basis. This study addresses organizational and institutional aspects that act as drivers for the establishment of successful university–industry partnerships. First, a series of regression models explain the determinants of R&D contracts. These models include two main dimensions: the university and the technology transfer office. Second, further analysis empirically explores whether universities in regions with a favorable environment enjoy greater active involvement in this particular knowledge transfer mechanism. The empirical study analyzes 2010 data for Spanish public universities. Results indicate that successful R&D contracts depend on university and TTO characteristics, and the university's location. The paper also presents a set of managerial implications for improving the establishment of university–industry partnerships. | publication |
222792 | Ocean sentinel | Fisheries are operating worldwide over nation’s Economic Exclusive Zones (EEZ) as well as over international waters. Information on the location of fishing is rarely known, especially in international waters, yet it is critical since in many oceanic sectors non declared and illegal fisheries are affecting negatively ecosystems through over exploitation and by catch of non-target species Knowledge about the distribution of fishing boats is fundamental for the regulation of fishing activities as well for the conservation of the oceans. I propose a New Concept of ocean surveillance based on new bio-logging technologies fitted on large foraging marine predators. The OCEAN SENTINEL Proof of this Concepts will (1) develop a logger called CENTURION that couple a XGPS platform detecting and locating radar emissions, with a satellite transmission system (Argos) that would send instantaneously the location of vessels to a receiving site, (2) deploy the logger on wide ranging animals used as platforms and (3) make available immediately the information obtained from the CENTURION logger through a website. The OCEAN SENTINEL programme will generate important social benefits by providing information to a wide range of beneficiaries, from governments or regional authorities managing EEZ and natural resources, regional or national fishing authorities, researchers and non-governmental organisation in conservation. The concept will be tested in the Southern Indian Ocean from Crozet and Kerguelen Islands where valuable and extensive fisheries operate in EEZs and over oceanic waters. This concept has the potential to be used in other areas where information on fisheries location is needed. The project will also lead to further discoveries on the relationship between seabirds and fisheries as well on the extent of fisheries in zones where surveillance by conventional methods is not possible. | project/european |
US 2005/0013025 W | BLOOD DRAWING DEVICE | A device for drawing fluid from a lumen, and particularly blood from a blood vessel, is disclosed. The device may provide indication of the entry of an intravenous cannula into the lumen. The device may include a central body having an outer wall and an inner fluid passage. The device may include a luer-type adapter to permit the attachment of an I.V. infusion set of various lengths ("butterfly needle") and or any luer-type fitting attached to an existing device. The outer wall of the central body may be transparent or translucent to permit the detection of fluid within the inner fluid passage. A front cannula may extend from one end of the central body and a rear cannula may extend from the other end of the central body. Both the front and rear cannulae may communicate with the inner fluid passage. A flexible sleeve may surround at least a tip portion of the rear cannula. A venting member may be provided near a base portion of the rear cannula between the flexible sleeve and the ambient. The venting member may permit the passage of air through it, but be substantially impermeable to liquids, such as blood. | patent |
978828 | Argonaut: from the synthesis of ganglioside tumour antigens to a platform for cancer active immunotherapy | Immunotherapy is currently revolutionizing cancer therapy by harnessing the power of the innate and adaptive immune system against cancer cells, thus providing a more tumour-selective approach in assistance to traditional treatments. The identification of tumour-associated carbohydrate antigens (TACAs), aberrant types of glycans decorating the surface of tumour cells, has paved the way for the development of new types of cancer vaccines. However, while significant progress has been made in this area of research, TACA-based cancer vaccines have not yet reached the clinic. In this context, ARGONAUT will address some limitations that characterize classical approaches in carbohydrate cancer vaccine development, with the overall aim of establishing a strategy to access novel, more effective, and fully synthetic vaccine candidates. ARGONAUT’s journey aims at the preparation of vaccine candidates based on ganglioside-type TACAs (expressed in melanoma, neuroblastoma, and small cell lung cancer) that are easy to formulate, able to elicit a immune response independent from individual polymorphisms, and with better chances to reach the clinical environment. Employing a synthetic carbohydrate chemistry approach, ARGONAUT explores its application as a tool to contribute to H2020 European efforts in cancer research, while providing excellent training in a multidisciplinary and intersectoral environment through a well-implemented work-plan. From another perspective, ARGONAUT’s impact will also benefit from the transfer of knowledge to the host institution with the establishment of a new research line in active cancer immunotherapy. | project/european |
W2013588387 | Histone deacetylases and epigenetic therapies of hematological malignancies | Histone deacetylase inhibitors (HDACi) represent a novel class of targeted drugs which alter the acetylation status of several cellular proteins. These agents, modulating both chromatin structure through histone acetylation, and the activity of several non-histone substrates, are at the same time able to determine changes in gene transcription and to induce a plethora of biological effects ranging from cell death induction, to differentiation, angiogenesis inhibition or modulation of immune responses. The impressive anticancer activity observed in both in vitro and in vivo cancer models, together with their preferential effect on cancer cells, have led to a huge effort into the identification and development of HDACi with different characteristics. To date, several clinical trials of HDACi conducted in solid tumors and hematological malignancies have shown a preferential clinical efficacy of these drugs in hematological malignancies, and in particular in cutaneous T-cell lymphoma (CTCL), peripheral T-cell lymphoma (PTCL), Hodgkin lymphoma (HL) and myeloid malignancies. Several agents are also beginning to be tested in combination therapies, either as chemo sensitizing agents in association with standard chemotherapy drugs or in combination with DNA methyltransferase inhibitors (DNMTi) in the context of the so-called "epigenetic therapies", aimed to revert epigenetic alterations found in cancer cells. Herein, we will review HDACi data in hematological malignancies questioning the molecular basis of observed clinical responses, and highlighting some of the concerns raised on the use of these drugs for cancer therapy. | publication |
174478 | Molecular dissection of titin-based mechanisms in charge of cardiomyocyte dysfunction in terminal feart failure | Chronic heart failure is a leading cause of mortality in the industrialized countries. Pathomechanistically, a variety of diverse stress signals on the cardiomyocyte trigger loss of myofibrils and cardiomyocyte death, thereby activating a vicious cycle of cardiac stress and deterioration during terminal heart failure. Despite the enormous clinical relevance, the exact pathomechanisms in charge remains unclear.
Here, I propose to investigate the molecular mechanisms that couple mechanical cardiomyocyte strain and cardiomyocyte loss during the heart failure involving the mechanosensing titin filament. For this, I will perform research in three globally leading teams and access their complementary expertise in a secondment scheme. In the the proposed 2-year outgoing phase, I will study how cardioprotection is mediated by key factors recently identified in the Ju Chen lab (UCSD, San Diego). During this time, I will be trained in cutting-edge molecular mouse genetic models and phenotyping tools. This research is expected to shed light on CARP-titinsignaling axis in cardiomyocyte death and to provide tools for manipulating this pathway. In a one-year re-integration phase I will perform follow-up mechanistic structural studies in the Olga Mayans lab (University of Liverpool) to determine the structural basis how the CARP (cardiac ankyrin repeat protein)-titin signaling axis mediates cardiomyocyte protection, and in the Labeit lab (University of Heidelberg, Medical Faculty Mannheim) how to perturb activity of this complex by small molecules.
Taken together, this work encompasses structural studies at the atomic level up to vivo animal models to study CARP-titin functions. After the propose three years, I expect to be ready to pursue an independent career in the field of molecular cardiology research. Therefore, my goal during the re-integration phase will be to set-up an interdisciplinary collaboration involving the three lead teams of this proposal. | project/european |
W2607618806 | THE ANALYSIS OF VALUE ADDED AS AN INDICATOR OF INTELLECTUAL CAPITAL AND ITS ASSOCIATION TOWARDS COMPANY PERFORMANCE | The principal purpose of this research is to investigate the association between the efficiency of value added (VA) by the major components of a firm’s resources base (physical capital, human capital and structural capital), and also the Value Added Intellectual Coefficient (VAICTM) toward the firm’s economic, financial and stock market performance. Data are drawn from a sample of 324 companies listed in Indonesia Stock Exchange for the year of 2009 which is divided into primary, secondary, and tertiary industry sectors.
The result is obtained by using multiple regression analysis. From the result, it is discovered that physical capital, structural capital and VAICTM have significant associations toward company’s economic, financial and stock market performance, while human capital only has significant association towards firm’s economic performance. The research result also shows that the contribution of intellectual capital differs across industry sectors. | publication |
W1981600310 | Fabrication of silicon carbide reinforced aluminum matrix nanocomposites and characterization of its mechanical properties using non-destructive technique | Abstract The SiC nanoparticulate reinforced Al matrix composites (with 2.5–12.5 vol%) were successfully fabricated by employing high energy ball milling with cold-pressing and sintering technology at 550 °C for 1 h. Microstructures and nanoparticulate distribution were analyzed with scanning electron microscope (SEM), X-ray diffraction (XRD) and transmission electron microscope (TEM). Mechanical property and hardness were studied using pulse echo overlap (PEO) method as a non-destructive technique. Microstructure analysis showed that the nanocomposites contained only α-Al and SiC phases with clean interface of thickness ∼1.5 nm, and preserved nano-grained network structure. The SiC nanoparticulates were distributed uniformly in a metal matrix, and neither voids nor cracks were detected at the interface of Al/SiC. Besides, there was no reaction product has been found at the interface. Accordingly, the mechanical properties of composites reinforced by SiC nanoparticulates were significantly improved, while the Poisson's ratio of nanocomposites was retained. This was mainly due to the stronger interfacial bonding derived from direct mechanical interlocking between the adjacent component surfaces. | publication |
interreg_2435 | Monument nomination and pilot implementation as an alternative form of architecture and religion tourism | The operation “Mo.No.Pi - Monument Nomination and Pilot Implementation as an Alternative Form of Architecture and Religion Tourism” focuses on the promotion of monasteries as important sites of cultural heritage. Monasteries frequently require significant amounts of resources for restoration and maintenance but, apart from being sanctuaries for contemplation, they can act as growth poles for the development of their surrounding areas. Objectives Based on a close cooperation of representatives of monasteries with governmental organisations, the operation wants to explore opportunities for an active role of monasteries in regional development. More specifically, it promotes the contribution of monasteries to economic development based on the range of possible usage types for religious, educational and/or tourism purposes and aims at developing policy tools to ensure sustainable management. Results The operation enhances public awareness for European religious and secular traditions. It improves available policies and tools to include monasteries into regional development strategies and bridges between traditional usage and modern interests. It thus helps overcome existing barriers and promotes the role of monasteries as enterprises, training facilities and religious centers. Activities include the set up of an interregional co-operation platform for monasteries and the identification of tools suitable for promoting the roles of monasteries in regional development. Partners conduct a range of case studies, elaborate new user concepts, prepare a handbook for the management of monasteries, and conduct a range of training seminars. | project/regional |
W2019089915 | Interactions between hearing loss and the spectral overlap of competing sounds in masked speech intelligibility. | This experiment explored the ideas that energetic masking (EM) limits the benefit achievable from spatial separation in a competing speech task and that differences in EM between normal‐hearing (NH) and hearing‐impaired (HI) listeners can explain differences in spatial release from masking (SRM). Target sentences and similar masker sentences (or in another condition, masker noises) were filtered into four narrow spectral bands and presented simultaneously. The spectral overlap of the target and masker bands was varied from minimal (interleaved bands) to maximal (identical bands). Both NH and HI listeners showed spectral tuning, such that masking by noise or speech was reduced as spectral overlap was reduced. In fact, this signal processing often improved intelligibility relative to that seen with unfiltered speech. Moreover, thresholds in the noise and speech maskers were closely related, suggesting that EM was the main factor limiting performance across tasks. More masking was found in HI as compared to ... | publication |
W2213094169 | Influence Analysis of Cracks of the Sluice Bottom Board | After running for half a year, periodic inspection to a discharge sluice shows that cracks in the direction of water current appear in the bottom board of most of sluice lockage chamber. Stress computation under the design conditions and the working conditions after cracks appeared are carried out with 3D-FEM respectively. The results indicated that the stress of the bottom board is still within the allowed range, the structure is safe from the view of the stress. But considering the defective parts of bottom surface and interlayer surface are likely to be connected with vertical cracks, seepage follow channel will be formed, and it will affect the long-term safe operation of the whole structure, it is suggested that cracks in bottom board should be repaired. | publication |
184862 | Salt tectonics and dynamics | Many of the world’s oil and gas reservoirs occur in the vicinity of salt structures within sedimentary basins. Because salt is a weak and low-density rock, it flows on geological timescales and forms kilometre-high structures that strongly deform nearby sedimentary layers. This poses several challenges for the industry:
1) Finding new oil and gas fields requires a geological reconstruction of how the sedimentary basin evolved with time, in order to understand where hydrocarbons formed, how they migrated and where they might be stored now. Existing geological reconstruction methods use simple kinematic rules, which don’t work well in regions that are affected by salt tectonics as salt flows in a 3D manner and over large distances.
2) Drilling through or nearby salt structures can pose a risk, as they perturb the stresses within the basin, which can cause drill holes to collapse and other costly delays in the drilling process.
To guide and assist oil exploration, we propose a radically different technique that relies on combining advanced computer simulations of the sedimentary basin with available data. Our method is able to reconstruct in a physically consistent manner the geological evolution of the basin, even if it is strongly affected by salt tectonics. It also predicts the 3D stress field of the subsurface together with uncertainty bounds, which will allow companies to design future drilling campaigns to be safer and more efficient. The recent drop in the price of oil has concentrated the industry’s exploration effort on increased-value projects, both by cutting costs for existing exploration methods and by further leveraging already acquired data via new interpretation techniques. We will address both of these industry requirements in areas where salt tectonics are prevalent. Within this proof of concept grant, we will work with industry partners to apply our methods to natural case studies and demonstrate its economic viability and cost-saving potential. | project/european |
W2168115404 | Myopia and Cognitive Dysfunction: The Singapore Malay Eye Study | To investigate a possible relationship between refractive error and cognitive function.This population-based, cross-sectional study included 1032 persons aged 60 to 79 who participated in the Singapore Malay Eye Study. Refraction (sphere, cylinder, and axis) was measured using an autorefractor, and spherical equivalent was defined as sphere plus half negative cylinder. Refractive errors were defined as myopia (spherical equivalent < -0.5), emmetropia (-0.5 diopter [D] ≤ spherical equivalent ≤ 0.5 D), and hyperopia (spherical equivalent > 0.5 D). Visual acuity was measured with a logMAR chart. Cognitive dysfunction, assessed using the Abbreviated Mental Test, was defined based on education-specific cutoff values.Compared with individuals with emmetropia, persons with myopia were almost twice as likely to have cognitive dysfunction (odds ratio 1.82; 95% confidence interval 1.05-3.15), after adjusting for age, sex, body mass index, income, education, and hours of reading and writing per day. Hyperopia was not associated with cognitive dysfunction. The association remained significant after further adjustment for uncorrected refractive errors or best-corrected visual acuity.Our results provide evidence on a novel association between myopia and cognitive dysfunction. | publication |
Q123338 | Diversification of business through the purchase of an innovative machine | The investment in question consists of the cost of new technology, which will allow the implementation of a new production process resulting in new products. Thanks to the implementation of the investment, the production process (world innovation) will be substantially changed and the offer will be extended to include a country-wide innovative product, which will be tools with a significantly higher level of innovation, produced on special order. The degree of difficulty in their execution narrows the number of suppliers to a very small number. | project/regional |
W1918228426 | THE MIRAGE TOOLBOX: AN INTEGRATED ASSESSMENT TOOL FOR TEMPORARY STREAMS | The assessment of the ecological status of water bodies, as requires by the European Water Framework Directive, can raise a number of problems when applied to temporary streams. These problems are because of the particular physical, chemical and biological conditions resulting from the recurrent cessation of flow or even the complete drying of the stream beds. In such non-permanent water bodies, the reference quality standards developed for permanent streams may only be applicable under certain circumstances or may not be applicable at all. Work conducted within the collaborative EU-funded project Mediterranean Intermittent River ManAGEment (MIRAGE) has addressed most of these difficulties and has used diverse approachesto solve them. These approaches have been brought together inthe so-called MIRAGEToolbox. This toolbox consists of a series of methodologies that are designed to be used in a sequential manner to allow the establishment of the ecological and chemical status of temporary streams and to relate these findings to the hydrological status of the streams. The toolbox is intended to serve the following purposes: (i) the determination of the hydrological regime of the stream; (ii) the design of adequate schedules for biological andchemicalsamplingaccordingtotheaquaticstateofthestream;(iii)thefulfillmentofcriteriafordesigningreferenceconditionstations;(iv)the analysis of hydrological modifications of the stream regime (with the definition of the hydrological status); and (v) the development of new methods to measure the ecological status (including structural and functional methods) and chemical status when the stream’s hydrological conditions are far from those in permanent streams. Copyright © 2014 John Wiley & Sons, Ltd. | publication |
EP 2010065711 W | NON-AQUEOUS PIGMENT DISPERSIONS USING DISPERSION SYNERGISTS | Non-aqueous pigment dispersions exhibiting improved dispersion quality and/or stability were prepared for a specific selection of quinacridone pigments, diketopyrrolo-pyrrole pigments and azo pigments by using specific naphthol AS dispersion synergists. The non-aqueous pigment dispersions can be advantageously used in inkjet inks inkjet printing methods. | patent |
W1614534501 | Pain Intensity and Pain Interference in Older Adults: Role of Gender, Obesity and Inflammation (P3.310) | Objectives: We examine whether the obesity and pain relationship is mediated by the inflammatory marker high-sensitivity C-reactive protein (hsCRP) and whether this relationship differs by sex. Participants included 667 community-residing adults over age 70, free of dementia enrolled in the Einstein Aging Study (EAS).
Background: Among older adults, pain intensity and pain interference are more common in women than men and associated with obesity and inflammatory markers.
Design/methods: Items from Medical-Outcomes-Study Short-Form 36 were used to measure pain intensity and pain interference in daily life. Ordinal logistic regression was used to assess the cross-sectional association among BMI, hsCRP levels, pain intensity and pain interference using gender-stratified models adjusted for demographic variables.
Results: In women, pain intensity was associated with obesity (BMI蠅30 vs. normal, OR=2.29, 95[percnt]CI 1.43-3.68) and higher hsCRP (OR=1.28, 95[percnt]CI 1.08-1.51). In a model with obesity and hsCRP, both remained significant but the association between hsCRP and pain intensity was somewhat attenuated. Obesity (OR=3.04, 95[percnt]CI 1.81-5.11) and higher hsCRP levels (OR=1.30, 95[percnt]CI 1.08-1.56) were also independently associated with greater pain interference in women. After adjustment for pain intensity and BMI, hsCRP was no longer associated with pain interference in women. Greater pain intensity and being overweight or obese continued to be significantly associated with pain interference in women. In men, obesity and hsCRP were not associated with pain intensity or pain interference.
Conclusions: In women, the relationship between obesity and higher levels of pain intensity or interference may be due, in part, to an increase in hsCRP. Disclosure: Dr. eslami has nothing to disclose. Dr. Katz has received research support from Bristol-Myers Squibb. Dr. White has nothing to disclose. Dr. Sundermann has nothing to disclose. Dr. Jiang has nothing to disclose. Dr. Ezzati has nothing to disclose. Dr. Lipton has received personal compensation for activities with Allergan, Inc., American Headache Society, Autonomic Technologies, Boston Scientific Corp., Bristol-Myers Squibb, CogniMed Inc., Colucid Pharmaceuticals, Eli Lilly & Company, eNeura Therape | publication |
643585 | Smart restoration with particle infused repointing | The objective of the proposed project is the development of a damage sensing material for application in structures of architectural heritage. This material comprises lime mortar infused with conductive carbon nano-particles, applicable for repair and strengthening of historic masonry buildings through repointing of mortar joints.
The proposed material is envisaged as possessing improved strength and ductility, which are critical in enhancing the durability of existing buildings. It relies on the electrical conductivity of the nano-particles for the detection of damage and the measurement of deformation in masonry structural elements.
The project begins with the optimisation of a nano-particle infused lime mortar mix. Subsequently, the characterization of the enhancement of the mechanical properties of the material is performed. This is followed by the development of a quantitative damage and deformation measurement protocol. The project is concluded by the testing of the material in full scale structural members. Through the up-scaling of novel materials and self-sensing technology, it encompasses a lab to industry transition.
In addition to being a cost-effective means of structural damage monitoring, the material is expected to moderately enhance the structural behaviour of masonry members, while adhering to the principles of intervention on historic structures. In light of the danger to the integrity and durability of historic buildings due to the peaking of induced earthquake and the increase of ground movement in European urban centres, the project is deemed timely and potentially deeply impactful.
The project is expected to greatly enhance the researcher's prospects for an academic career, in addition to sharpening his technical and research grant proposal writing skills. Further, it is expected to provide, in the long term, an excellent contribution to research, innovation potential, industry and society. | project/european |
171432 | Localization in biomechanics and mechanobiology of aneurysms: towards personalized medicine | Rupture of Aortic Aneurysms (AA), which kills more than 30 000 persons every year in Europe and the USA, is a complex phenomenon that occurs when the wall stress exceeds the local strength of the aorta due to degraded properties of the tissue. The state of the art in AA biomechanics and mechanobiology reveals that major scientific challenges still have to be addressed to permit patient-specific computational predictions of AA rupture and enable localized repair of the structure with targeted pharmacologic treatment. A first challenge relates to ensuring an objective prediction of localized mechanisms preceding rupture. A second challenge relates to modelling the patient-specific evolutions of material properties leading to the localized mechanisms preceding rupture. Addressing these challenges is the aim of the BIOLOCHANICS proposal. We will take into account internal length-scales controlling localization mechanisms preceding AA rupture by implementing an enriched, also named nonlocal, continuum damage theory in the computational models of AA biomechanics and mechanobiology. We will also develop very advanced experiments, based on full-field optical measurements, aimed at characterizing localization mechanisms occurring in aortic tissues and at identifying local distributions of material properties at different stages of AA progression. A first in vivo application will be performed on genetic and pharmacological models of mice and rat AA. Eventually, a retrospective clinical study involving more than 100 patients at the Saint-Etienne University hospital will permit calibrating estimations of AA rupture risk thanks to our novel approaches and infuse them into future clinical practice. Through the achievements of BIOLOCHANICS, nonlocal mechanics will be possibly extended to other soft tissues for applications in orthopaedics, oncology, sport biomechanics, interventional surgery, human safety, cell biology, etc. | project/european |
W2170672854 | Evolutionary Meta-Analysis of Association Studies Reveals Ancient Constraints Affecting Disease Marker Discovery | Genome-wide disease association studies contrast genetic variation between disease cohorts and healthy populations to discover single nucleotide polymorphisms (SNPs) and other genetic markers revealing underlying genetic architectures of human diseases. Despite scores of efforts over the past decade, many reproducible genetic variants that explain substantial proportions of the heritable risk of common human diseases remain undiscovered. We have conducted a multispecies genomic analysis of 5,831 putative human risk variants for more than 230 disease phenotypes reported in 2,021 studies. We find that the current approaches show a propensity for discovering disease-associated SNPs (dSNPs) at conserved genomic positions because the effect size (odds ratio) and allelic P value of genetic association of an SNP relates strongly to the evolutionary conservation of their genomic position. We propose a new measure for ranking SNPs that integrates evolutionary conservation scores and the P value (E-rank). Using published data from a large case-control study, we demonstrate that E-rank method prioritizes SNPs with a greater likelihood of bona fide and reproducible genetic disease associations, many of which may explain greater proportions of genetic variance. Therefore, long-term evolutionary histories of genomic positions offer key practical utility in reassessing data from existing disease association studies, and in the design and analysis of future studies aimed at revealing the genetic basis of common human diseases. | publication |
W2171326573 | Modeling unimolecular reactions in photoelectron photoion coincidence experiments | A computer program has been developed to model and analyze the data from photoelectron photoion coincidence (PEPICO) spectroscopy experiments. This code has been used during the past 12 years to extract thermochemical and kinetics information for almost a hundred systems, and the results have been published in over forty papers. It models the dissociative photoionization process in the threshold PEPICO experiment by calculating the thermal energy distribution of the neutral molecule, the energy distribution of the molecular ion as a function of the photon energy, and the resolution of the experiment. Parallel or consecutive dissociation paths of the molecular ion and also of the resulting fragment ions are modeled to reproduce the experimental breakdown curves and time-of-flight distributions. The latter are used to extract the experimental dissociation rates. For slow dissociations, either the quasi-exponential fragment peak shapes or, when the mass resolution is insufficient to model the peak shapes explicitly, the center of mass of the peaks can be used to obtain the rate constants. The internal energy distribution of the fragment ions is calculated from the densities of states using the microcanonical formalism to describe consecutive dissociations. Dissociation rates can be calculated by the RRKM, SSACM or VTST rate theories, and can include tunneling effects, as well. Isomerization of the dissociating ions can also be considered using analytical formulae for the dissociation rates either from the original or the isomer ions. The program can optimize the various input parameters to find a good fit to the experimental data, using the downhill simplex algorithm. | publication |
W1982863375 | Giardia intestinalis: effects of Pulsatilla chinensis extracts on trophozoites | Pulsatilla chinensis is a medicinal root plant that has been used to treat a wide range of disease conditions. Our study determined the antiprotozoal activity of various P. chinensis extracts and fractions against Giardia intestinalis including their effects on parasite growth, cell viability, adherence, and morphology. Ethyl acetate extracts (IC50 = 257.081 μg/ml) were the most active to inhibit the growth of G. intestinalis followed by aqueous extract (PWE), saponins, and n-butanol extract. The PWE and ethyl acetate extract inhibited G. intestinalis trophozoites adherence after 3 h of incubation and killed almost 50 % of the parasite population in a time-dependent manner. Changes in morphology, presence of precipitates in the cytoplasm, dissolved cytoplasm with large vacuole, break of flagella and ventral disk, membrane blebs, and intracellular and nuclear clearance of the treated trophozoites were observed by scanning and transmission electron microscopy. We demonstrated that P. chinensis induced these changes in G. intestinalis morphology and consequently has potential therapeutic use against giardiasis. | publication |
W2059243726 | Who Receives Food Stamps During Adulthood? Analyzing Repeatable Events With Incomplete Event Histories | Abstract Using data from the Panel Study of Income Dynamics (PSID) from 1968 to 2005, we estimate the cumulative probability that young adults in the United States will receive food stamps during adulthood, and examine how that probability varies with an individual’s income and education at age 25 as well as by race and gender. We find that the probability of first food stamp receipt as an adult declines sharply with age, indicating that most adult recipients do so by age 40. Also, those receiving food stamps in early adulthood are likely to receive them again. For these reasons, and because food stamp receipt is a repeatable event, life table analyses that include individuals who are not observed until after they become exposed to the risk of food stamp receipt (whom we label “late entrants”) are likely to overstate cumulative participation during adulthood. For example, one often-cited study included individuals who enter their sample after age 20 (late entrants) and report that 50.8% of 20-year-olds are recipients by age 65. In contrast, when we exclude late entrants, we find that 39.2% of 20-year-olds and 29.7% of 25-year-olds receive benefits during adulthood. | publication |
Q4416227 | Development of a high-performance digital imprinting device and chemical markers to verify the authenticity of the reflective film used in the production of license plates | Number_reference_aid_programme: SA.41471(2015/X) Purpose of public aid: art: 25 EC Regulation No 651/2014 of 17 June 2014 declaring certain categories of aid compatible with the internal market in the application of Articles 107 and 108 of the Treaty (OJ L 119, p. That’s it. EU L 187/1 of 26.06.2014). The subject of the project is to carry out research and development works that will enable the development of a prototype of a digital device for imprinting and chemical markers to verify the authenticity of the reflective film used in the production of registration plates (process innovation) and the boards with print containing a chemical marker (product innovation). License plates, in which a reflective film with print and marker will be used, will be plates whose falsification will be much more difficult. In addition to many other safety elements currently used by the Applicant in the production of license plates, the safety elements in the form of chemical markers will allow identification by quick and simple verification of the effect of the excitation caused by the illumination of the imprint with a marker using a laser radiation source, but also product identification through the use of appropriate detectors, which will verify the unique and unique spectrum with the characteristics that are compared with the recorded pattern. The compatibility of the standard with the signal received will allow to assess whether the array is authentic. The production of the boards described above will be possible thanks to the development of a prototype of the printing device, which the Applicant plans to use in industrial activities, after the project has been completed. This device will be able to print inks with the addition of chemical markers on the first generation reflective film and on prismatic films. The device will be characterised by a number of improvements, compared to the currently owned by the Applicant of the Industrial Multifunctional Graphic Device | project/regional |
interreg_2211 | Alla ricerca dei colori e dei tessuti del Mediterraneo | The local artisan products at risk of disappearing: we must consider whether to give new value to the tradition for new professions related to the sustainable use of local resources. The multifunctionality of agriculture can develop new job opportunities especially for rural women and the company has to deal with environmental protection, rural tourism, craft activities. The added value of traditional products is in their intrinsic qualities and sensory and cultural enhancement. The areas of study are the province of Grosseto in Tuscany, the province of Sassari in Sardinia and the Middle Campidano, the provinces of North and South of Corsica. The project aims to develop capacity for innovation, creation and application of processes and products in small and medium-sized enterprises of agriculture, handicrafts (textile-dyeing and herbal) and tourism. The project aims to enhance native species of plants and wool for the production of handicrafts and textiles for the use of green building and promote cultural tourism and territories with the educational-teaching. The targets are micro-enterprises and SMEs agriculture, crafts and tourism organizations that benefit directly and / or indirectly the development of rural areas. The activities will include: characterization of local resources and their intrinsic qualities and sensory integration of analysis with the application of marketing strategies and sensory environment of the territories as a basis for actions that promote the sustainability of each other territories of the three regions of the Tyrrhenian Sea.
| project/regional |
Q2031204 | PORO-HUESO (DISEÑO OPTIMIZADO DE CELOSÍAS ORTOPÉDICAS Y BIOMATERIALES EN LAS EXTREMIDADES) | ESTE PROYECTO CONJUNTO TIENE COMO OBJETIVO DISEÑAR E IMPLEMENTAR UNA SOLUCIÓN TECNOLÓGICA OPTIMIZADA PARA EL DISEÑO INNOVADOR Y LA PRODUCCIÓN DE BIOMATERIALES PARA PRÓTESIS ORTOPÉDICAS. EN PARTICULAR, LAS TECNOLOGÍAS DE FABRICACIÓN 1.ADDITIVE (IMPRESIÓN 3D) SE UTILIZARÁN DE FORMA COMBINADA, CON HERRAMIENTAS DE OPTIMIZACIÓN DE PROCESOS RELACIONADAS; 2.I SW DE DISEÑO DE ESTRUCTURAS POROSAS Y OPTIMIZACIÓN TOPOLÓGICA DE LA MISMA, CON EL FIN DE CREAR UN ENFOQUE PARA EL DISEÑO | project/regional |
EP 2018073194 W | PROTRANSDUZIN-D - IMPROVED ENHANCER OF GENE TRANSFER | The invention relates to a polypeptide having the sequence Z1-Gln-Ala-Lys-Ile-Lys-Gln-Ile-Ile-Asn-Met-Trp-Gln-Z2. The polypeptide is used for retroviral transfection/transduction. | patent |
interreg_2286 | METEORISK - Mitigation of natural risks through improved forecasting of extreme meteorological events | Extreme meteorological events originate in one part of the Alps and proceed over or along the alpine crest. The effects of these events are inundations, landslides, avalanches, Föhn storms etc., which do not occur outside of the Alps in this form. The forecasting of these events is limited by the lack of structured communication between the weather services in these areas and the lack of online available data before and during these events.
The object of METEORISK is:
1- to establish a network of online automatic meteorological stations densifying the existing
station network.
2 - The improved interpretation of different regional models and radar data of the area.
3 - Optimized communication, common training and networking between the forecasters.
4 - The improvement of the interaction with the the civil protection authorities and the public
through adequate instruction material.
5 - A statistical analysis to quantify the occurence of extreme events in the different part of the Alps. | project/regional |
W2018734408 | Effects of continuous positive airway pressure on cognitition and neuroimaging data in sleep apnea | Obstructive sleep apnea (OSA) has been associated with a broad range of neurocognitive difficulties. The current view is that the neurocognitive impairment in OSA is due to the adverse effects of sleep fragmentation and/or intermittent hypoxia. The overall picture of cognitive deficits in OSA is complex. On balance, there appears to be negative effects of OSA on cognition, most likely in the domains of attention/vigilance, verbal and visual delayed long-term memory, visuospatial/constructional abilities, and executive dysfunction. Continuous positive airway pressure (CPAP) is the most effective and widely used treatment of OSA. In the majority of studies of OSA patients treated with CPAP, attention/vigilance improved, but changes in global functioning, executive functioning, and memory improved in about half of the studies. This may be due, in part, to variability in study design and sampling methodology across studies. Structural volume changes have been demonstrated in brain regions of OSA patients including areas that regulate memory and executive function (e.g., frontal cortex, anterior cingulate, and hippocampus). Growing evidence suggests that the OSA-related changes in brain morphology may improve with CPAP treatment. Neuroimaging studies performed during cognitive testing have provided insight into CPAP's effect on function of neuroanatomical circuits in the brain. Although neuroimaging can provide important insights into the structural and functional differences associated with OSA, one of the challenges is to interpret the findings in light of comorbid conditions that also cause neural injury. The purpose of this article is to provide a narrative review of the publications on cognition and neuroimaging in OSA before and after CPAP treatment. | publication |
W2594661527 | Training Convolutional Neural Networks Based on Ternary Optical Processor | A novel platform and algorithms of Ternary Optical Computer (TOC) are proposed to training Convolutional Neural Network (CNN). It can significantly improve the concurrency and throughput of the training process of CNN. Reviewing the irrelevance data and the inherent parallelism module of the CNN, this paper discusses the preprocessing way of arbitrary number of two-dimensional data which include feature maps, convolutional kernels and mini-batches. Then strategies of parallel training of CNN based on the reconfigurable flexible arithmetic operator are proposed. All these arithmetic units are implemented by the optical Modified Signed Digit (MSD) adder and optical MSD multiplier, which are carry-free differing from the electronic computers. The massive data-bits of TOC are reconfigurable and redistributable, so fully parallel pipeline of the CNN can be sufficiently achieved. The computational complexity of the algorithms in time are analyzed. The result shows that TOC has great benefits comparing to the GPU and FPGA in concurrency, needed cycle and hardware resources resumed. This paper provides a new perspective to efficiently address computation-intensive and data-intensive issues. | publication |
EP 2019053045 W | COOKING APPLIANCE | A cooking appliance (10) comprises a housing (11) which de- fines a food preparation cavity (12), heating means for heat- ing the cavity (12), and a door (14) for selectively closing and opening the cavity (12). The cooking appliance (10) is characterized by the cooking appliance (10) further comprising a horizontally movable linkage system connected to the housing and the door (14), wherein the linkage system is configured to move the door between a closed position in which the door bears against the front side (15) of the housing (11) to close the oven cavity (12), via an intermediate position in which the door is lifted off from the front side of the housing, and an open position in which the door is positioned laterally aside the oven cavity, wherein during the entire path of movement the door is held in a vertical orientation. | patent |
interreg_310 | Enhancing Innovation and Sustainability in Adriatic Aquaculture | The project aims at building up synergies between industries and research Institutes to satisfy the innovation demand of Italian and Croatian farmed fish food chains. Thanks to advanced environment-friendly/cost-effective farming protocols, healthier and tasteful fish products will increase competitiveness of SMEs on regional and international markets. Following the suggestion of the EUSAIR action plan for the aquaculture sector, to strengthen stakeholder involvement and to improve skills and product diversification, the project will involve aquaculture-targeted research groups, fish farms, fish processing industries, public associations of both countries. Their pre-established collaboration will allow creating concrete actions addressed to fish farmers and SMEs processing the fish. | project/regional |
W1511723527 | Rituales, derechos y relaciones: algunas donaciones y su interpretación en el cartulario de Fulda, c 827 | This article analyses a cluster of legal documents concerning newly cleared woodland between the river Fulda and its minor tributary the Haune, copied into the earliest Fulda cartulary which was completed in 828. It elucidates the complex interactions between local landholders of varying status, the monks of Fulda and their claims to spiritual patronage and tenurial right, and the public world of legal ritual and county meetings which were central to the exercise of power in the Carolingian world. It argues that the legal rituals recorded in charters were simultaneously attempts to define and regulate the relationships between different social actors (individuals, groups and institutions) as well as to transfer rights over property. Historians need to pay particular care to the mechanisms of transmission, as the archival record wa s carefully constructed to meet immediate needs, and it may obscure the extent to which relationships and the rights embedded in them were matters of interpretation. As well as raising epistemological and methodological questions about the nature of the charter evidence, this discussion also sheds light on the nature of land claims and clearances, and the relationship between internal colonisation and the crystallisation of ecclesiastical and political structures under Carolingian rule, topics which parallel the concerns of much recent work on early medieval Iberia. Finally, it is argued that if charter sare read not of passive records of abstract rights but as active attempts to interpret social relations, they can shed some light on the identities and interests of landowners of relatively modest means, and place them at historiographial centre stage. | publication |
W2789672194 | U-Pb geochronology and coupled Hf-Nd-Sr isotopic-chemical constraints of the Cassiterita Orthogneiss (2.47–2.41-Ga) in the Mineiro belt, São Francisco craton: Geodynamic fingerprints beyond the Archean-Paleoproterozoic Transition | Abstract The Cassiterita Orthogneiss is the oldest pluton so far found within the Mineiro belt. In situ zircon U-Pb ages constrain the crystallization of the Cassiterita Orthogneiss to between 2472 ± 11 and 2414 ± 29 Ma. Zircon overgrowths are dated at 2024 ± 54 Ma, which matches the timing of the regional metamorphic overprint in the main belt. One metatonalite dike yields a zircon U-Pb age of 2156 ± 17 Ma, while a single inherited core is concordant at 2426 ± 17 Ma. The studied rocks exhibit low to medium grade metamorphism, and show tonalitic and granodioritic composition akin to TTG suites (tonalite-trondhjemite-granodiorite). The trace element patterns suggest that partial melting and fractional crystallization operated in the genesis. The La/Yb N , Yb N , Sr/Y, Nb/Ta and Zr/Sm values point to a garnet amphibolite residue. The positive e Nd(t) (+5.2 to +1.3) and low 87 Sr/ 86 Sr i (0.700–0.702) isotopic signatures suggest a LREE- and/or LILE LILE-enriched MORB mantle source. The zircon e Hf(t) parameters (-8.0 to +2.9) of the studied samples indicate some crustal assimilation during magma genesis. The chemical and isotopic signatures of the Cassiterita Orthogneiss are similar to nearby (ca. 2.35 Ga) TTG plutons, interpreted as cogenetic. This peculiar plutonism (from 2.47 to 2.35 Ga) marks the earliest stage of a long-lived accretionary regime (2.47–2.00 Ga) that built the Mineiro belt. This earliest orogenic event is roughly coeval with the (chemical) sedimentary infill of the passive basin (Minas Supergroup), previously dated at ca. 2.42 Ga. The age matches suggest a geodynamic link between the oceanic arc magmatism and penecontemporaneous basin infill in the continental margin. Early Paleoproterozoic TTG plutons such as the Cassiterita Orthogneiss have been related to the earliest accretionary processes that developed away from continental margins, where roughly coeval dike swarms and A-type plutons are emplaced along with the onset of passive basins. We explore the potential association and temporal interplay between convergent and intraplate settings and other major changes beyond the Archean-Paleoproterozoic Transition. | publication |
2728144 | Flexible energy production, demand and storage-based virtual power plants for electricity markets and resilient dso operation | FEVER will implement and demonstrate solutions and services that leverage flexibility towards offering electricity grid services that address problems of the distribution grid, thus enabling it to function in a secure and resilient manner. The project encompasses technologies and techniques for extraction of energy flexibilities from virtual and explicit energy storage (batteries, V2G) and demand response. FEVER will leverage the potential for flexibility due to the electrification of sectors such as heating (heat pumps, district heating) and cooling (e.g. industrial refrigeration). In FEVER we will implement a comprehensive flexibility aggregation, management and trading solution that incorporates intelligence around the optimal flexibility orchestration and is capable to offer flexibility services in different markets (local, wholesale). In addition, a peer-to-peer flexibility trading toolbox will be implemented with a distributed ledger technology enabling autonomous peer-to-peer trading. FEVER will implement a set of goal-oriented applications and tools that empower DSOs with optimal grid observability and controllability. The DSO toolbox will include advanced monitoring and automated control functions (critical event prevention, self-healing, island-mode power management, etc.). FEVER will carry out extensive demonstration and testing activities in multiple settings. For scalability assessment the project includes large scale simulations of novel market mechanisms for day-ahead and continuous trading of flexibility services, and simulations of wholesale-retail market coupling.These simulations will contribute to the quantification of the impact of flexibility services at the distribution grid level and beyond (transmission level). FEVER’s holistic approach to flexibility will facilitate establishing and operating appropriate business models for all players in the market, thereby providing the EU with a secure, efficient and resilient electric grid. | project/european |
interreg_660 | Quality Circulation of the goods on the premises of the logistics station of the program | This project studies the structure and operation of a Cross-Boarding Area Management Platform (CAMP) that can function as a Logistics Single Window for an integrated and paperless logistics chain. CAMP integrates a network of interoperable platforms at the service of shippers and logistics chain actors. The selected supply chains share the one-stop-shop concept. It involves customers and suppliers to create a credible tool for SMEs to globalise products in a cross-border way and make transport more competitive. The area in question involves secondary and tertiary nodes, for a closer relationship with the primary cluster (port nodes and inland transport routes of people and goods). While capitalising on the results of previous projects, this research study will enhance the appeal of nodes by quantifying the reduced total transport chain time economically. The architecture is designed to maximise adaptability, flexibility and scalability to support modal balance and communications between different size businesses and Authorities (and between Authorities) with different computer and service capabilities. For future IT implementations, this project aims to define the logical system and metadata needed to operate a platform by surveying the needs of businesses. CIRCUMVECTIO for freight transport and NECTEMUS for passengers intend to deal with critical cross-border area issues, due to the mixed demand for maritime traffic between the continent and the islands. | project/regional |
EP 2011074214 W | ARTIFICIAL LIFT TOOL | The present invention relates to an artificial lift tool for being introduced in a wellbore or a casing and submerged in well fluid. The artificial lift tool extends in a longitudinal direction from a top end adapted to be connected to a wireline to a bottom end. The tool comprises a motor unit and a pump unit. Furthermore, invention relates to a production well wherein the artificial lift tool is submerged in a well fluid; to the use of the artificial lift tool for providing artificial lift in a well; and to a method for providing artificial lift in a well. | patent |
W4210822873 | Lógica, formação escolar e filosofia entre os jesuítas | Lógica, formação escolar e filosofia entre os jesuítas Resumo: O interesse mais direto deste artigo é a relação entre a Lógica e a formação filosófica na educação jesuíta. Para compor uma imagem da importância e da concreção da Lógica na formação proposta pelos inacianos, nós nos concentraremos na Ratio Studiorum e na obra do jesuíta português Pedro da Fonseca (1526-1599). A razão do recorte proposto é que as reflexões de Fonseca sobre o tema parecem, por um lado, orientar outros jesuítas, como é o caso de Sebastião do Couto, que é o autor da dialética do Curso Conimbricense; por outro, elas são mais completas, sobretudo pela atenção dada por Fonseca ao método e às disputationes. De posse do conceito de Lógica de Fonseca, concluímos com a indicação de caminhos contemporâneos de revisitação de lógicas do passado. Palavras-chave: lógica; método; educação; jesuítas. Logic, school education and philosophy among the Jesuits Abstract: The most direct interest of this article is the relationship between Logic and philosophical formation in Jesuit education. In order to produce an image of the importance and concretion of Logic in the formation proposed by the Ignatians, we will focus on the Ratio Studiorum and on the work of the Portuguese Jesuit Pedro da Fonseca (1526-1599). The reason for the proposed approach is that Fonseca's reflections on the subject seem, on the one hand, to guide other Jesuits, such as Sebastião do Couto, who is the author of the dialectic of Curso Conimbricense; on the other hand, Fonseca’s conception of logic is more complete regarding the other Jesuits, especially due to the attention given by our author to the method and the disputationes. In possession of Fonseca's Logic concept, we conclude with an indication of contemporary paths for revisiting the logics of the past. Key-words: logic; method; education; Jesuits. Logica, educazione scolastica e filosofia tra i gesuiti Abstract: L’interesse più diretto di questo articolo è il rapporto tra Logica e la formazione filosofica nell’educazione dei gesuiti. Per produrre un’immagine dell’importanza e della concretezza della Logica nella formazione proposta dagli inaziani, ci concentreremo nella Ratio Studiorum e nell’opera del gesuita portoghese Pedro da Fonseca (1526-1599). Il motivo di questa scelta è che le riflessioni di Fonseca sull’argomento sembrano, da un lato, guidare gli altri gesuiti, come Sebastião do Couto, cioè, l’autore della dialettica del Curso Conimbricense; da l’altro, la concezione di logica di Fonseca è più completa riguardo ad’altri gesuiti, soprattutto per l’attenzione data dall’autore al metodo e alle disputationes. Possedendo il concetto di logica di Fonseca, concludiamo con l’indicazione di modi contemporanei di rivisitare le logiche del passato. Parole chiave: logica ; metodo ; educazione ; gesuiti. Data de registro: 16/09/2021 Data de aceite: 01/12/2021 | publication |
628926 | A fully integrated, animal-free, end-to-end modelling approach to oral drug product development | Oral drug products are preferred by hundreds of millions of patients in Europe. Yet, the challenges around formulating drugs for oral administration have increased tremendously over the last 30 years, mainly because most drugs coming through the Pharma pipeline are too poorly soluble to be efficiently absorbed from the GI tract. A quantum leap in identifying the optimal formulation for a new drug in the most efficient way possible is urgently needed to keep the Pharma industry in Europe competitive. Further, due to the enormous challenges in formulating poorly soluble drugs for oral administration, the numbers of animals used to screen formulation prototypes are increasing, despite EU commitment to reducing animals in research. The InPharma Consortium provides a unique solution to solving these important challenges.
The InPharma EID will strengthen Europe’s innovation capacity and leadership in the Pharma sector, specifically in drug formulation. Exceptional intersectoral training will be provided to 13 ESRs through pioneering research focused on harnessing computational pharmaceutics, Biorelevant in vitro testing and PBPK modeling, generating an integrated, end-to-end, animal-free approach to formulating poorly soluble drugs for oral administration. ESRs will undergo specialized training program to build proficiency in essential research and industry disciplines, while training in professional skills and entrepreneurship will prepare them to become trailblazers in pharmaceutical formulation.
A highlight of InPharma is the proven, successful collaboration among Consortium experts in the design, evaluation and implementation of enabling formulations for oral delivery. This EID will immerse ESRs in highly dynamic industrial environments under the supervision of leading academics, exposing them to all elements of pharmaceutical formulation, fostering collaboration, catalyzing synergies across the network and ultimately creating a truly unique training experience. | project/european |
AU 2015/312634 A | Electronic device with bent display and method for controlling thereof | A electronic device and a display method thereof are provided. A control method of the electronic device includes: detecting a touch input on an auxiliary display area; in response to a touch input being detected on a first area of the auxiliary display area in a and the electronic being in a state in which the electronic is gripped by a user, processing the touch input as a user input; and, in response to the touch input being detected on a second area of the auxiliary display area different from the first area and the electronic being in the state in which the electronic is gripped by the user, disregarding the touch input. | patent |
W1912619538 | Ongoing Cerebral Vasculitis During Treatment of Rocky Mountain Spotted Fever | Rocky Mountain spotted fever is a tickborne infection that produces a systemic small-vessel vasculitis; its prognosis is excellent if appropriate treatment is initiated early. Because the advent of effective antirickettsial therapies predates the widespread use of brain magnetic resonance imaging, there are limited data on the effect of untreated Rocky Mountain spotted fever infection on neuroimaging studies.We describe a 7-year-old girl with delayed treatment of Rocky Mountain spotted fever who suffered severe neurological impairment. Serial brain magnetic resonance images revealed a progressive "starry sky appearance," which is proposed to result from the same small vessel vasculitis that causes the characteristic skin rash of this infection.Neurological injury can continue to occur despite specific antirickettsial therapy in Rocky Mountain spotted fever. This child's clinical features raise questions about the optimal management of this infection, particularly the utility of immune modulating therapies in cases of delayed treatment and neurological involvement. | publication |
W2368187690 | Research on progresses and directions of location model in ubiquitous computing | Location model plays an important role in ubiquitous computing and the Internet of Things,which can help to implement the fusion of physical world and information world.An overview of location models is provided.It focuses on several aspects,including basic principles and approaches of location model,location reasoning,location representation methods, ontology-based models,and geospatial ontology.Especially the most popular ontology-based location models are compared and contrasted.A number of location models are developed specifically for use in pervasive computing,none of which appears to cover adequately unified concept model,rich location logics,powerful reasoning capability.A multidisciplinary intersection approach to researching location model,combining location theory,ontology theory,and geospatial theory,is pointed out in order to obtain a unified location model with powerful reasoning ability. | publication |
W4293194348 | O governo da justiça na Guiana Francesa sob ocupação portuguesa (1809-1817) | Resumo A historiografia recente sobre as práticas administrativas na América portuguesa tem-se consagrado às instituições e aos agentes responsáveis pela aplicação da justiça nas diversas regiões e capitanias, sem, entretanto, ter abordado um território conquistado pelos portugueses no início do século XIX. A proposta deste artigo é a análise da administração da justiça na Guiana Francesa entre os anos de 1809 e 1817, época em que o território esteve sob ocupação portuguesa. Considerada por Dom João VI como parte de seus “Estados”, a Guiana foi governada por dois agentes portugueses sob dependência da capitania do Grão-Pará. A partir da comparação entre as estruturas jurídicas coloniais francesa e portuguesa, buscou-se analisar as adaptações empreendidas pelos portugueses para o bom governo da justiça na Guiana, pois, como ficou estipulado pela capitulação, o Código Civil francês continuou em vigor na colônia. O artigo evidencia, ainda, o papel desempenhado por João Severiano Maciel da Costa como intendente da Guiana. O estudo utiliza documentos conservados no Arquivo Nacional do Rio de Janeiro (AN), na Biblioteca Nacional (BN), no Arquivo Histórico do Itamaraty (AHI), no Arquivo Ultramarino Francês (ANOM) e no Arquivo Departamental da Guiana (ADG). | publication |
W2632696273 | Effects of the major sudden stratospheric warming event of 2009 on the subionospheric very low frequency/low frequency radio signals | This paper presents effects of the major Sudden Stratospheric Warming (SSW) event of 2009 on the sub-ionospheric Very Low Frequency/Low frequency (VLF/LF) radio signals propagating in the earth-ionosphere waveguide. Signal amplitudes from four transmitters received by VLF/LF radio networks of Germany and Japan corresponding to the major SSW event are investigated for possible anomalies and atmospheric influence on the high to mid-latitude ionosphere. Significant anomalous increase or decrease of nighttime and daytime amplitudes of VLF/LF signals by ∼3-5 dB during the SSW event have been found for all propagation paths associated with stratospheric temperature rise at 10 hPa level. Increase or decrease in VLF/LF amplitudes during daytime and nighttime is actually due to the modification of the lower ionospheric boundary conditions in terms of electron density and electron-neutral collision frequency profiles and associated modal interference effects between the different propagating waveguide modes during the SSW period. TIMED/SABER mission data are also used to investigate the upper mesospheric conditions over the VLF/LF propagation path during the same time period. We observe a decrease in neutral temperature and an increase in pressure at the height of 75-80 km around the peak time of the event. VLF/LF anomalies are correlated and in phase with the stratospheric temperature and mesospheric pressure variation, while minimum of mesospehric cooling shows a 2-3 day delay with maximum VLF/LF anomalies. Simulations of VLF/LF diurnal variation are performed using the well known Long Wave Propagating Capability (LWPC) code within the earth-ionosphere waveguide to explain the VLF/LF anomalies qualitatively. | publication |
887026 | Training research pioneers by utilizing and validating the promise of electroporation for minimal invasive oncological treatments. | The ElectroPros action aims to optimally prepare young researchers for the evolving technology in the healthcare space, especially related to minimal invasive oncology therapies, by offering a unique set of targeted interdisciplinary training and research assignments in the areas of biophysics modelling and simulation, device physics, optimization algorithms, software integration and experimental validation. Four European Industrial Doctorate positions are offered to Early Stage Researchers (ESRs) for a period of three years. In the training program a combination of industrial, academic and clinical research environments are provided by Philips, the University Clinic Aachen and RWTH Aachen, to explore the field of electroporation, as a new and promising technique for minimal invasive oncology treatment.
Based on sound career development plans, and coached by experienced supervisors, the four ESRs involved will develop a competence profile which will springboard their future career in the wide European medical community in the industrial, clinical and academic domain. These researchers have the potential to become pioneers for new minimally-invasive therapies for the oncology domain.
During their training, the ESRs will work on electroporation based treatment of cancer. The ESRs address shortcomings of the currently available equipment to enable for the first time ever a reliable patient-specific electroporation based treatment for cancer. With a focus on liver cancer, the ESRs will collectively establish novel insights on the biophysical effects on various tissues, important to understand the treatment effect, and integrate this knowledge in optimal device (needle) design and multi-physics models for treatment outcome prediction and inverse planning algorithms. Furthermore, the developed assets will be integrated in clinical prototype software to support and optimize the clinical workflow. | project/european |
220091 | An integrated computational and experimental approach to rapid synthesis of highly selective dual-targeted hdac/ck2, mmp2/ck2 inhibitors | Traditional drug design strategy based on a single target has serious difficulties in developing new therapies for diseases such as cancer.
Cancer is a very complex multi-genetic disease that involves multiple crosstalks between signaling networks. The use of cocktails of various anticancer agents interfering with different mechanisms has been the standard treatment to prevent the problems of resistance.
An alternative approach is to design multi-target modulators, directed to different disease mechanisms. That is the approach we have chosen for this project, where we seek to design, synthesize and evaluate new dual agents based on the inhibition of three enzymes involved in the development and progression of tumor processes: HDAC1, CK2 and MMP2.
CK2 is a serine / threonine kinase that is constitutively active and essential for cell viability. Its proliferative and anti-apoptotic properties create a favorable cellular environment for tumor progression and maintenance and, therefore, constitutes an interesting target for the treatment of cancer.
Acetylation/deacetylation of histones is one of the epigenetic mechanisms that regulates gene expression. HDACs (histone deacetylases) remove acetyl groups from histones, inducing condensation of chromatin and, therefore, the repression of gene transcription. For this reason, they are considered key targets to reverse aberrant epigenetic changes associated with cancer.
Matrix metalloproteinases (MMPs), also called matrixins are another family of Zn-dependent enzymes. Our research group has extensive experience in the design and synthesis of inhibitors of MMP2 provided with high activity and, more importantly, high selectivity over other metalloproteinases. The design of multi-target modulators will be carried out making use of computational techniques and based on the previous experience of the group in the design and synthesis of inhibitors of these three targets through a fragment based process. | project/european |
W2616145760 | Signs and stability in higher-derivative gravity | Perturbatively renormalizable higher-derivative gravity in four space–time dimensions with arbitrary signs of couplings has been considered. Systematic analysis of the action with arbitrary signs of couplings in Lorentzian flat space–time for no-tachyons, fixes the signs. Feynman [Formula: see text] prescription for these signs further grants necessary convergence in path-integral, suppressing the field modes with large action. This also leads to a sensible wick rotation where quantum computation can be performed. Running couplings for these sign of parameters make the massive tensor ghost innocuous leading to a stable and ghost-free renormalizable theory in four space–time dimensions. The theory has a transition point arising from renormalization group (RG) equations, where the coefficient of [Formula: see text] diverges without affecting the perturbative quantum field theory (QFT). Redefining this coefficient gives a better handle over the theory around the transition point. The flow equations push the flow of parameters across the transition point. The flow beyond the transition point is analyzed using the one-loop RG equations which shows that the regime beyond the transition point has unphysical properties: there are tachyons, the path-integral loses positive definiteness, Newton’s constant [Formula: see text] becomes negative and large, and perturbative parameters become large. These shortcomings indicate a lack of completeness beyond the transition point and need of a nonperturbative treatment of the theory beyond the transition point. | publication |
175111 | Intelligent trading interface | The challenges of modernizing the electricity grids in Europe lie in enabling an increased flexibility of the European power system and enabling an active participation of users and new market actors. Demand response enables end users to participate actively in energy markets and profit from optimal price conditions, making the grid (heat, cold, electricity) more efficient and contributing to the integration of renewable energy sources. At the same time the Energy Efficiency Directive adopted in 2012 contains provisions to encourage market actors to facilitate demand response.
Our product – Intelligent Trading Interface (ITI) is designed to speed up adoption of Demand Side Management (DSM) systems. ITI is an interface between Virtual Power Plant (VPP) Control Centre and prosumer’s Energy Management System (EMS). It is a building block of a modular VPP system, thus enabling the participation of new technology players for making an optimal VPP solution and bring more competition and innovation on the VPP market. With reduced initial investment needed, end users (prosumers) are more likely to participate in Demand Response Management (DRM) programs, at the same time achieveing the savings estimated at 5-10 % of the total electricity costs.
Existing and evolving VPP suppliers are considered customers, rather than competition. By addressing several additional business cases (aggregators, OEM for EMS suppliers, transmission and distribution system operators), we increase market potential for ITI.
Designed, using knowledge and expertise, gained from development and demonstration of INEA's complete VPP product, ITI contains state-of-the art technologies and concepts for VPPs of the future. Open Top and Open Bottom functionalities make ITI compatible with wide range of existing and evolving VPP and EMS solutions.
During Phase 1 we plan to assess defined use and market cases and specify additional functional and technological requirements for ITI exploitation. | project/european |
W2028874886 | Colour Impressions Framework | Abstract Selection of appropriate colour for a particular purpose of information dissemination is crucial to ensure the accuracy of information. Colour plays an important role in multimedia design and can be considered as a critical component of any design. Good selection and use of colour can improve the quality of the presentation of information in multimedia design. Colour covers many aspects of human life from the scientific field to the field of sociology. Psychological aspect as a clash point of these two different fields also agreed with the role of colours in influencing human perception. Inappropriate use of colour can seriously reduce the effect, objective, and quality of the information convey through multimedia design. Impression produce by colour gives various feeling to the viewer. Different mode of colour on presenting the multimedia will lead to different situation or condition. Multimedia design tools had offered lots of colour to be used by user, but there is no tool such as colour corrector on impression of colours used in designing multimedia interface is available. Research on the classification on impression for two- colours on individual with different personalities had been done by Sato and Mitsukura, and 80% of the combination of two- colours can be classified by impression. Further studies had been suggested on this area. The objective of this study is to construct a framework to identify the impression exist in combination of two colours. The framework will be used to find the perception of culture and life style of Malaysians. The study investigates the impression resulting from the combination of two colours that will gain insights from five abstract painters in Malaysia. The injection of impression on colour palette is wished to improve the human perception and feel on designing multimedia application. | publication |
225407 | Fiscal consolidation, unemployment and labour mobility in the euro area | In the aftermath of the crisis, unfavourable socio-economic conditions with high unemployment, steep decreases in salaries and welfare allowances, and deterioration in career prospects have triggered intensified labour mobility, with a direction from the so-called Peripheral countries to the Core of the euro area. Primarily due to the surge in immigration from its EU partners, Germany is now the second largest immigration country in the industrialised world, after the U.S. Fiscal consolidation policies that aim to reduce deficit levels and typically involve tax hikes and cuts in government spending have also contributed to these migration outflows from crisis-hit countries. Notably, in countries with a sizeable public sector, like Greece and Spain, cuts and restrictions in new recruitments of public employees have further motivated the decision to move abroad. The aim of this research is to theoretically study the macroeconomic links between unemployment, fiscal consolidation, and labour mobility in a monetary union. To this end, I will introduce endogenous migration decisions both for the unemployed and the employed household members in a two-country Dynamic Stochastic General Equilibrium model of a monetary union with search and matching frictions, in which the Periphery implements fiscal consolidation through spending cuts or tax hikes. Existing studies in the fiscal consolidation literature consider an immobile labour force and, therefore, the migration channel has not yet been investigated in this context. This project aims to fill this gap and inform policymakers by comparing different fiscal consolidation instruments: (a) labour income tax hikes, (b) public consumption spending cuts, (c) unemployment benefits cuts, and (d) public sector wage bill cuts. Through the lens of the model, I will also perform a systematic comparison of the implications for different euro area Peripheral economies, which have implemented a different policy mix in the recent years. | project/european |
185118 | Single molecule imaging of transmembrane protein structure and function in their native state | TransPhorm will pioneer a transformative technology platform based on Nitrogen Vacancy (NV) magnetometry to enable the structure and function of transmembrane proteins (TMPs) to be studied in their native state with unprecedented sensitivity and resolution. TMPs reside in the membrane of biological cells and are critical to cellular function and communication. It is essential that TMPs are characterised in their native state as their structure and function is dependent on their interaction with the local environment. This is technically demanding and despite previous attempts using a multitude of complementary techniques no single method has provided a suitable solution. Here a breakthrough approach will be taken to demonstrate in situ TMP characterisation with single molecule sensitivity, nanoscale spatial resolution and millisecond measurement speed.
The concepts proposed in TransPhorm are distinct from current implementations of NV magnetometry for detection and mapping of weak magnetic fields originating from external nuclear spins. Here magnetic field mapping will be achieved using a totally new approach based on widefield, high speed structured illumination total internal reflection microscopy. The concepts TransPhorm are built on will also enable structural and functional single molecular characterisation with high specificity by exploiting the outstanding sensitivity to the local environment of fluorine-19 Nuclear Magnetic Resonance (NMR) reporters and the ion selectivity of sodium-23 and potassium-39 NMR spectroscopy.
In short, TransPhorm will deliver a ground-breaking technology to far surpass current state-of-the-art techniques and provide the extreme sensitivity needed to understand the molecular scale dynamic changes that underpin TMP function. Overall the strategy and technologies proposed here will pave an untravelled path to the realisation of nanoscale NMR imaging and deliver tremendous scientific gains. | project/european |
W757740880 | Square-wave voltammetric determination of rosuvastatin calcium in pharmaceutical and biological fluid samples using a cathodically pretreated boron-doped diamond electrode | Abstract The analytical potential of a boron-doped diamond electrode (BDD) and square-wave voltammetry (SWV) for the determination of rosuvastatin calcium (ROS) was investigated. The voltammetric response of the ROS molecule was evaluated with a BDD electrode that was subjected to anodic (positive polarization, + 3.0 V for 5.0 s) or cathodic (negative polarization, − 3.0 V for 15.0 s) pretreatments. The target analyte showed an irreversible anodic process at ≈ 1.4 V (vs. Ag/AgCl (3.0 mol L − 1 KCl)) with an enhanced current response at a BDD electrode that was cathodically pretreated. Using the cathodically pretreated BDD electrode, other experimental conditions were optimized, including the supporting electrolyte and SWV parameters. Under optimized experimental conditions, the analytical curve was linear in the ROS concentration from 9.40 to 88.8 mg L − 1 (9.40 to 88.8 μmol L − 1 ), with a correlation coefficient of 0.998 and limit of detection of 1.04 mg L − 1 (1.04 μmol L − 1 ). The proposed method was successfully applied for ROS determination in pharmaceutical formulations and the electrochemically determined quantity of drug was in close agreement with the results obtained using a spectrophotometric method at the 95% confidence level. Additionally, biological fluid samples of urine and human serum were directly analyzed by the proposed voltammetric procedure, with excellent results of recovery. | publication |
W4281673116 | Nota sobre educación lingüística y pandemia: retos y oportunidades de la didáctica a distancia en Italia | por Marianna Montanaro | publication |
ES 358885 A | METHOD FOR PUNCHING AN OPENING IN A SYNTHETIC PLASTIC CONTAINER SECTION BLANK AND FORMING RIBS THEREON | A hole is punched in the base of a cold plastics container blank B, and an outwardly extending curled rim formed around the hole, by a reciprocating punch 11 which co-operates with a stationary platen 17 having an opening 18 which receives the reduced leading section 20 of the punch. The blank B is provided with an inwardly-directed stiffening rib 15 and a curved fold section 16. In operation the punch is forwarded into the opening 18 and severs the bottom wall 14 of the blank. Further movement of the punch causes the shoulder 21 on the punch to engage the rib 15 thereby causing the section 16 to be deformed under the axial pressure as shown in Fig. 5. The punch is then withdrawn and the fold section, due to the inherent elasticity of the cold plastics material, partially regains its former shape to form the desired rim. In a second embodiment (see Figs. 8-14, not shown), the stiffening rib is omitted from the blank, the necessary axial pressure being derived by contact of the platen 10 carrying the punch with the web P surrounding the blank. | patent |
219862 | Cachem: probing clustering of x-ray agn using chandra and semi-empirical models | The presence of a supermassive black hole (BH) in almost all galaxies in the Universe is an accepted paradigm in astronomy. How these BHs form and how they co-evolve with the host galaxy is one of the most intriguing
unanswered problems in modern Cosmology and of extreme relevance to understand the issue of galaxy formation.
Clustering measurements can powerfully test theoretical model predictions of BH triggering scenarios and put constraints on the typical environment where AGN live in, through the connection with their host dark matter halos.
This project wants to probe the clustering properties of X-ray AGN from both an observational and theoretical point of view, using the new catalog of AGN detected by Chandra in COSMOS and semiempirical models.
The Chandra COSMOS-Legacy (CCL) catalog is the largest available sample of X-ray AGN for clustering studies, allowing clustering measurements as a function of obscuration, luminosity and AGN host galaxy properties for the first time up to z~3-4 and with the accuracy needed to model the AGN halo occupation.
We also propose to generate mock catalogs of galaxies and BHs assigned via semi-empirical relations to large samples of dark matter halos. Via detailed comparisons of the predictions from the mocks with the AGN clustering at different scales, redshifts and obscuration cuts, we will set unique constraints on the BH/galaxy properties driving the clustering measurements of CCL AGN, especially of obscured sources. This in turn is crucial to understand the AGN/galaxy co-evolution and to test different BH triggering scenarios at different epochs.
SNS will constitute for the Applicant an invaluable and unique environment at the European level, where she will achieve extreme competence in both theory and observations. Her profile will become extremely relevant with the advent of large dedicated extra-galactic European missions such as EUCLID, eRosita, Athena. | project/european |
176049 | Safety enables cooperation in uncertain robotic environments | The majority of existing robots in industry are pre-programmed robots working in safety zones, with visual or auditory warning signals and little concept of intelligent safety awareness necessary for dynamic and unpredictable human or domestic environments. In the future, novel cognitive robotic companions will be developed, ranging from service robots to humanoid robots, which should be able to learn from users and adapt to open dynamic contexts. The development of such robot companions will lead to new challenges for human-robot cooperation and safety, going well beyond the current state of the art. Therefore, the SECURE project aims to train a new generation of researchers on safe cognitive robot concepts for human work and living spaces on the most advanced humanoid robot platforms available in Europe. The fellows will be trained through an innovative concept of project-based learning and constructivist learning in supervised peer networks where they will gain experience from an intersectoral programme involving universities, research institutes, large and SME companies from public and private sectors. The training domain will integrate multidisciplinary concepts from the fields of cognitive human-robot interaction, computer science and intelligent robotics where a new approach of integrating principles of embodiment, situation and interaction will be pursued to address future challenges for safe human-robot environments. | project/european |
W4281900057 | Estado, Política Industrial e Tecnológica: reflexões sobre alternativas para a retomada da indústria brasileira | The objective of the article is, through a review of the relevant literature, to discuss alternatives for industrial and technological development for Brazil.What we seek to demonstrate is that despite the restrictive view of multilateral organizations (World Bank and WTO) whether regarding the role of the state or the role of industrial and technological policies, it is possible to pursue a path of resumption of Brazilian industrial development.The presence of a proactive and disciplinarian state is paramount. | publication |
216701 | Miniature beam-driven plasma accelerators | As we push the frontier of particle physics to higher particle energies, conventional accelerator techniques are attaining their limits and new concepts are emerging. The use of an ionized gas —or plasma— circumvents the most significant barrier of conventional techniques by increasing the energy gained per unit length by several orders of magnitude. One class of plasma accelerators, relevant for high energy physics applications, consists in using a particle beam, « the driver », to excite a plasma wave, that is then used to accelerate the main particle beam. Research in this field requires large facilities, due to stringent conditions on the driver. In the M-PAC project, I propose to power plasma accelerators with laser-accelerated electron beams based on 100-TW-class laser systems, so as to miniaturize the so-called “beam-driven plasma accelerators”. The project crosses the boundary of the fields of research of laser acceleration and of beam-driven plasma acceleration. With these innovative miniature versions, the goal of the M-PAC project is then to tackle, through experiments and simulations, the next Grand Challenges facing the field of beam-driven plasma acceleration, bringing plasma accelerator technology to viability for high energy physics collider applications. They include the generation and preservation of the excellent beam quality required for high-energy colliders and next-generation light sources, the demonstration of high drive-to-main-beam energy efficiency and the acceleration of the antimatter counterpart of the electron, the positron. Finally, the miniature beam-driven plasma accelerators open new opportunities to push university-scale plasma-based light sources to the next level, both in terms of brightness and spectral range. | project/european |
W1864039562 | Assessment of Soil Erosion and its Impact on Humus Spatial and Temporal Dynamics. | The purpose of this study is to quantify soil surface erosion using the Universal Soil Loss Equation in GIS environment and to assess its impact on soil humus reserve. The quantifying of soil surface erosion was performed by integrating in GIS the thematic raster representations of the erosion control parameters which exhibit spatial variability within the limi ts of the study region (Dobrovăţ Basin, The Central Moldavian Plateau, eastern Romania). Soil erodibility was computed according to ICPA (1987) standards, on the basis of soil type, texture and erosion degree, using a soil map of the basin at scale 1: 5000. Slope length was derived from a 20m resolution digital elevation model using SAGA-GIS software, while slope factor was determined according to the Romanian methodology by raising the slope values at the power of 1.5. Finally, the vegetation factor was computed on the basis of the normalized difference vegetation index derived from a 2001 Landsat image, using the equation proposed by Van der Knijff et al. (1999). Subsequently, we derived the potential soil erosion, controlled exclusively by soil-relief factors and the effective soil erosion, by integrating the effect of vegetation. The potential soil erosion show a mean value of 15.6 t/ha yr and a standard deviation of 16.6 t/ha yr. The integration of the vegetation effect decreases the mean value to 5.4 t/ha yr and the standard deviation to 6.7 t/ha yr. Most of the basin’s surface (48.7%) falls into the reduced erosion risk class (2-8 t/ha yr), while the high and very high erosion risk classes group 7.3% of the basin. The assessment of the erosion impact on soil carbon stock was performed by coupling the USLE model with a Hénin -Dupuis mono-compartmental humus evolution model. The simulation was performed for the first 20cm of the soil profile, using a database of 224 soil profiles. The results of the simulation show that 76% of the soil profiles display a regressive evolution of the humus reserve under the impact of the soil erosion. The mean humus loss for these profiles is 36.3 t/ha for 100 years of simulation. | publication |
W1973271441 | Behçet’s disease associated with celiac disease: a very rare association | There are common findings between Behçet's disease (BD) and celiac disease (CD); however, association in the same patient is a rarity. We relate the third case in the literature of this overlap in a 40-year-old woman with history of obstipation since her childhood. She also presented asymmetric polyarthralgia, loss of weight, anemia, oral recurrent aphthas (>3/year) and genital ulcerations, inflammatory lower back pain, bowel bleeding and abdominal colic. Afterwards, she presented episodes of erythema nodosum, superficial thrombophlebitis, pseudofolliculitis and aseptic meningitis, thus fulfilling criteria for BD. Due to persistence of the digestive complaints, a gastrointestinal endoscopy was performed. The biopsy showed chronic duodenitis with intraepithelial lymphocytosis, crypt hyperplasia, and villous atrophy. Endomysial antibody was positive. She fulfilled the diagnosis criteria for CD; a gluten-free diet was applied with clinical improvement. Ascertaining whether pathogenic mechanisms are common in these two conditions requires further investigation. | publication |
W4362571754 | La resistencia desde los márgenes: tres relatos de ciencia ficción sobre la Ciudad de México | Proponemos un análisis de tres cuentos de ciencia ficción mexicana: de Erika Mergruen, “La plaga” (2014); de Andrea Chapela, “Como quien oye llover” (2020) y de Verónica Zamora Morán, “Querida Tali” (2021), desde la óptica de su representación de una Ciudad de México futura, distópica y caótica, pero en pie. Los tres cuentos sitúan la acción en un futuro en el que la ciudad ha sido devorada por alguna de sus amenazas actuales o posibles: la sobrepoblación, una inundación, una guerra nuclear. Al imaginarla aún reconocible y habitable, transmiten la idea de una urbe resistente, que a pesar de las crisis políticas, sociales o naturales, insiste en seguir de pie. En esto, las autoras se suman a un corpus narrativo que tiene como tópico la Ciudad de México caótica pero resistente, que representa su diversidad sociocultural y la yuxtaposición de sus etapas históricas. Mergruen, Chapela y Zamora usan el potencial de la ciencia ficción para sumar, a las capas pasadas y presentes, un futuro posible de la capital. | publication |
184647 | Genetic dissection of a tonically active neural circuit | Understanding how the brain works is a fundamental challenge in biology and a priority of EU research. A subset of brain circuits can signal tonically to encode persistent stimuli. Such circuits are involved in many sensory systems (e.g. vision, hearing) and in homeostatic responses (e.g. temperature, pH, and posture control). How tonic activity is molecularly achieved remains poorly understood. In C. elegans a tonic circuit promotes aggregation behavior and escape from 21% oxygen. At its core this circuit comprises URX oxygen sensors that tonically stimulate RMG interneurons as oxygen approaches 21%, evoking a switch in behavioral state. Each neuron in the circuit can be imaged and selectively modified in vivo - providing a special opportunity to dissect a tonically active circuit. Genetic screens have isolated 74 mutants with behavioral defects linked to URX-RMG tonic activity and that appear to disrupt hitherto unstudied loci. I am currently identifying the genes defective in these mutants, something I expect to achieve by May 2016 when the Fellowship would begin. I propose to combine genetics, neural imaging, optogenetics and biochemistry to characterize these genes’ function. I expect to define groups of gene products that act together. Some will be hitherto uncharacterized in any animal. I propose to collaborate with partners in the host institute and elsewhere to characterize the function of conserved genetic pathways I discover in depth. I will gain added value from learning new approaches (e.g. biochemistry, CLEM, cell-specific RNA Seq) and by extending some of my findings into a vertebrate model. I expect my research to provide general insights into molecular mechanisms by which tonic circuits work, with potential implications for human disease. This project is likely to pioneer new lines of research indispensible to establish an independent research career, will broaden and deepen my technical expertise, and will help me develop new scientific networks. | project/european |
W2105711374 | Selective Exposure: New Methods and New Directions | This special issue of Communication Methods and Measures tackles difficult questions relating to the empirical study of politically motivated selective exposure. In this brief response, I reflect on the state of the research area and attempt to bring these articles into conversation with one another and with the larger field. My essay is organized in terms of four broad themes: the debate over selective avoidance, the value of big data, the changing technological landscape, and the emphasis on boundary conditions. Collectively, the works in this issue raise important methodological questions and provide theoretical and empirical guidance for how scholars might answer them going forward. Coupled with innovative theorizing, these insights promise to advance our field in important ways. | publication |
3726665 | Bioinspired-Polyamidoamine/Nanoparticle coatings as high-performing flame retardants for cellulosic fabrics | PANACEA project dealt with the design of bioinspired-polyamidoamine/nanoparticle coatings as high-performing flame retardants (FRs) for cellulosic fabrics. The main purpose is to synthesize environment-friendly, non-toxic FRs with performances comparable to those of the best traditional FRs currently used for cellulosic textiles. The overall objective is to study novel coatings based on polyamidoamines (PAAs), a family of synthetic water-soluble biocompatible and biodegradable polymers, bearing in their repeating units the same organic functions present in proteins, that were proven efficient FRs for cotton by the PANACEA supervisor. PAA preparation can be considered green and scalable as obtained by stepwise polyaddition of prim- or sec-amines to bisacrylamides in water, at room temperature and with no added catalysts. Furthermore, the synergism between PAAs and some nanoparticles (NPs) will be studied and exploited for i) improving the FR properties of selected PAAs and ii) reducing the final add-on of the most performing PAAs. PAAs with carboxylic or guanidine groups will be combined with layered double hydroxides and zinc borate nanorods in order to suppress cotton combustion in the most drastic fire scenarios, guaranteeing a low emission of combustion products. In parallel, sulphur-based-PAAs will be combined with graphene and graphene oxide with different sizes and oxidation grades. These coatings will be obtained by a water-based finishing treatment of impregnation/exhaustion and/or Layer-by-Layer assembly of biocompatible PAAs and NPs. Both these approaches are easily scalable, hence adaptable to the needs of pre-industrial production, conclusive objective of PANACEA. To this aim, the durability of such treatments will be objective of the project and achieved by initially grafting of FR PAA bearing reactive vinyl terminals through radical reactions in the presence of thermal or redox initiators, and then interacting with specific synergist NPs. | project/european |
W2010097144 | Influence of Post Fit and Post Length on Fracture Resistance: An in vitro Study | As root filled teeth often have insufficient coronal tooth structure, placement of a post is occasionally necessary to provide adequate retention for the core and final restoration. The aim of the present study was to investigate (i) the impact of post fit (form-congruence) and (ii) the influence of post length on the fracture resistance of severely damaged root filled extracted teeth.Forty single-rooted human teeth were root filled and divided into four groups (n = 10 per group). Post spaces were prepared with a depth of 6 mm (groups 1, 3) and 3 mm (groups 2, 4). Form-congruence with a maximal fit of the post within the root canal space was obtained in groups 1 and 2, whereas there was no form-congruence in groups 3 and 4. In all groups, glass fiber reinforced composite (FRC) posts were adhesively cemented and direct composite crown buildups were fabricated without a ferrule. Specimens were subjected to thermocycling and cyclic loading followed by application of static load until failure. Loads-to-failure [in N] were compared among the groups.Post fit did not have a significant influence on fracture resistance, irrespective of the post length. Both groups with post insertion depths of 6 mm resulted in significantly higher mean failure loads (group 1: 274.27 N; group 3: 277.16 N) than the groups with post space preparation of 3 mm (group 2: 250.40 N; group 4: 255.48 N).Within the limitations of this study, the fracture resistance of teeth restored with FRC posts and direct resin composite crowns without ferrules was not influenced by post fit within the root canal. These results imply that excessive post space preparation aimed at producing an optimal circumferential post fit is not required to improve fracture resistance of roots. | publication |
W1978451552 | Modeling and Simulation of Five-Axis Milling Machine Based on ADAMS | A method for motion control and analysis of five-axis milling machine was proposed by means of simulation. The method started from solid modeling of five-axis milling machine in PRO/E, and then imported the model into ADAMS, generating its own solid model, through seamless interface software Mechanism/Pro 2005. Therefore, co-simulation of PRO/E and ADAMS was realized. On the platform of ADAMS, constraints and drivers necessary for simulation was added to the solid model and the simulation was begun. During the simulation process, motion parameters of each head were produced, and these information directly provided a control basis for NC machining of five-axis milling machine. Thus, the performance study of five-axis milling machine through simulation was realized on the computer and it provided an effective method for the engineering design of the machine. | publication |
2716816 | A genomic and macroevolutionary approach to studying diversification in an insect-plant arms race | The exuberant proliferation of herbivorous insects is often attributed to their association with plants, making their interactions of particular importance to understanding what is driving their vast diversity. Early biologists exploring the underlying factors proposed the hypothesis of coevolution (and the escape and radiate model). Despite general support for this hypothesis, the macroevolutionary and genomic consequences of the origins and evolutionary dynamics of host-plant shifts remain elusive. Recent results illustrate the need for a multidisciplinary approach to assessing the role of host plants in shaping insect diversity at macroevolutionary scales. Using the swallowtail butterflies (Papilionidae) and their host plants, this project will develop a macroevolutionary and genomic framework to studying the origin and evolution of an arms race through time and space. We will build a complete species-level phylogeny for Papilionidae relying on whole-genome sequencing for all species. This time-calibrated phylogeny will be combined with species traits to estimate ancestral host-plant preferences and subsequent host-plant shifts. We will reconstruct dated phylogenies of the main host-plant families to estimate whether the butterflies and their host plants diversified concurrently through time and space. Diversification rates will be estimated for shifting/non-shifting and prey/non-prey clades. A matching genomic survey will to look for genes under positive selection by comparing sets of phylogenetic branches that experienced a host-plant shift versus branches without such a shift. Transcriptomes will be characterized for caterpillars and their plants to identify and pinpoint the genes involved in the arms race, as well as to compare them across the swallowtail tree of life. With this ambitious research proposal, we aim to provide answers to longstanding and fundamental evolutionary questions on the mechanisms behind ecological interactions over long timescales. | project/european |
W1487341810 | Contusive spinal cord injury up regulates mu-opioid receptor (mor)gene expression in the brain and down regulates its expression in the spinal cord: possible implications in spinal cord injury research | Traumatic spinal cord injury (SCI) is one of the dreaded neurological conditions and finding a cure for it has been a hot area of research. Naloxone - a mu-opiate receptor (mor) antagonist was considered for SCI treatment based on its positive effects under shock conditions. In contrary to animal studies based reports about the potential benefits of naloxone in treating SCI, a large scale clinical trial [National Acute Spinal Cord Injury Study II (NASCIS II)] conducted in USA failed to witness any effectiveness. The inconsistency noticed was intriguing. Therefore, the objective of the present study was to re-examine the role of naloxone in treating SCI using a highly standardised Multicenter Animal Spinal Cord Injury Study (MASCIS) animal model of contusive SCI. Results indicated that naloxone produced negligible and insignificant neuroprotection. In an attempt to understand the cause for the failure, it was found that mu-opioid receptor (mor) gene expression was upregulated in the brain but was down regulated in the spinal cord after contusive SCI. Given that the beneficial effects of naloxone are through its action on the mor, the results indicate that unlike the brain, spinal cord might not be bracing to utilise the opiate system in the repair process. This could possibly explain the failure of naloxone treatment in NASCIS II. To conclude, opiate antagonists like naloxone may be neuroprotective for treating traumatic brain injuries, but not for traumatic/contusive spinal cord injuries. | publication |
W3131536933 | TECHNICAL EFFICIENCY IN LAND USE FOR SOYBEAN CROPPING BY SMALL FARMS EVIDENCES FROM NORTHERN MATO GROSSO, BRAZIL | Nuestro objetivo fue analizar la eficiencia de los pequeños agricultores en Mato Grosso que cultivan soja. Se empleó el método de la Análisis de la Envoltura de Datos (AED) y verificamos los factores que afectan la eficiencia con un modelo logit. Los resultados demostraron que solo pocos agricultores son eficientes en el cultivo de soja porque esta producción se basa en economías de escala debido a los altos costos involucrados en el paquete tecnológico. Se identificaron dos prácticas principales para reducir la dependencia de los pequeños agricultores de las economías de escala: con contratos entre agricultores y tradings para financiar los costosy la adquisición de maquinaria usada o contratos de servicios en sustitución de nuevos equipos. La soja demostró ser económicamente viable también en agricultores ineficientes, pero requiere el desarrollo de mejores políticas para ser sostenible. | publication |
W2362231384 | Research advances on pasture management model | The healthy and production level of natural pasture,which is one of the most important utilization terminals of grassland,depend on its management level.With the developing of information technologies,and the quantifying and segmenting of ecological studies,studies on pasture management model and how to use these models to guide actual production have become one of the hotspots of modern grassland agricultural study.As one of grazing system models,pasture management model is the decision support system(DSS) of grassland production and livestock production.It simulates the effects of different production and management modes,and guides actual production,by collecting data of grassland growth,livestock growth,livestock production and management modes.To provide references for domestic researches on pasture management model,research advances on pasture management model at home and abroad were reviewed,and further prospect on development of pasture management model in future was made in this study. | publication |
W2316966112 | Insights Into the Development of Alcoholic Chronic Pancreatitis at Soweto, South Africa | We asked why so few working-class Africans of Soweto have chronic pancreatitis (CP) when alcoholism is the norm.Twenty-one alcoholics with acute psychosis but normal pancreas were investigated for lifestyle, micronutrient status, electrophilic stress, and iron overload.Alcoholics consumed more ethanol daily than did 14 previously studied patients with CP (P = 0.003); cigarette usage was similar; both groups had even poorer vitamin C status than 14 healthy controls, and no participant had iron overload. The CP group had higher scores for exposure to occupational xenobiotics than did alcoholics (P < 0.05), with lower plasma glutathione (P = 0.047) and urinary inorganic sulfate (P = 0.009). Further analysis identified hyperhomocysteinemia in the alcoholic set, with lower vitamin B12 (P < 0.001), higher folic acid (P = 0.003), and similar vitamin B6 levels compared with controls.The transition from alcoholism to CP in Soweto is associated with occupational exposure to xenobiotics. Among detoxification systems that are strained thereby, glutathione and inorganic sulfate depend on methionine intake, which is ample in Sowetans, whereas vitamin C, which exerts a glutathione-sparing effect, is deficient. Hence, a daily tablet of vitamin C may enable community prophylaxis against the disease--but homocysteine status would need monitoring. | publication |
W1987806279 | Acquisition of Clostridium difficile by piglets | Clostridium difficile is recognized as an important cause of nosocomial diarrhoea in humans especially in association with administration of antibiotics. In pigs, C. difficile can cause neonatal enteritis and can be isolated from faeces from both diseased and healthy animals. The presented prospective study describes how soon C. difficile can be isolated from newborn piglets after normal parturition and how C. difficile spreads within a pig farm. Six sows, their farrowing crates and their litters at one farm were sampled until C. difficile was found in all piglets. Within 48 h after birth, all 71 piglets became positive for C. difficile (two piglets were already positive within 1h post partum), all sows became positive within 113 h after parturition and the farrowing crates were found intermittently positive. C. difficile could also be detected in air samples and in samples of teats of the sows. All isolates belonged to PCR ribotype 078. Twenty-one C. difficile ribotype 078 isolates, found at the farm, were further analyzed by MLVA (multiple-locus variable-number tandem repeat analysis) and belonged to one clonal complex, except one isolate. To be sure that piglets were not born already infected with C. difficile ribotype 078, 38 caesarean derived piglets were sampled immediately after surgery. All piglets tested negative at delivery and stayed negative for C. difficile ribotype 078 during the 21 days in which they were kept in sterile incubators. This study shows that C. difficile ribotype 078 spreads easily between sows, piglets and the environment. Vertical transmission of C. difficile ribotype 078 was not found and is very unlikely to occur. | publication |
Q4770742 | LIGURBONIFICHE SIMPLIFIED LIMITED LIABILITY COMPANY | LIGURBONIFICHE OPERATES IN THE FIELD OF DISINFESTATION AND BASES ITS ACTIVITY ON A SOLID EXPERIENCE DEVELOPED IN THE FIELD OF CIVIL, INDUSTRIAL AND ENVIRONMENTAL HYGIENE. THE COMPANY OFFERS SERVICES BOTH FOR PRIVATE CUSTOMERS AND FOR PUBLIC ADMINISTRATIONS AND FOR OWNERS OF HOMES, VILLAS AND ADMINISTRATORS OF CONDOMINIUMS OR ENTREPRENEURS OPERATING IN VARIOUS PRODUCT SECTORS (HEAVY OR FOOD INDUSTRY). IN DETAIL, THE COMPANY OFFERS VARIOUS SERVICES FROM DISINFESTATION TO GRAFFITI REMOVAL, THROUGH DISINFECTION, FUMIGATION, SANITATION OF PREMISES, THE FOOD INDUSTRY AND DERATTISATION. AS FAR AS DISINFESTATION IS CONCERNED, THIS IS THE SET OF OPERATIONS TO LIMIT THE SPREAD AND PROLIFERATION OF PARASITES, AND ALL THE DAMAGE THEY MAY CAUSE. THE ACTIVITY OF THE COMPANY CONSISTS OF RETURNING TO AN ENVIRONMENT THE DEGREE OF HYGIENE AND SAFETY NECESSARY FOR YOU TO LIVE THERE, WITH THE AIM OF OFFERING OPTIMAL AND LASTING RESULTS. | project/regional |
W2385752919 | Application of AMSR-E Brightness Temperature Data in Observation and Simulation of Soil Moisture Variation over Northeast Plateau | An estimation model of soil moisture from the AMSR-E brightness temperature data was coupled into the WRF-Noah mesoscale numerical model for improving the observation and model simulation ability of soil moisture over Northeast Plateau.The main condusions are as follows: Firstly the land surface soil moisture(SM) in the northeastern part of the Qinghai-Tibet Plateau was estimated by the AMSR-E brightness temperature data.Its value was something lower than the observed and the NCEP reanalysed data,but regional distribution was reasonable and the temporal variation showed a quick response to the daily precipitation.Sencondly,the estimated SM was assimilated into the WRF-Noah model by using the Newtonian relaxation assimilation method.By fine tuning of the quality factor in the Newtonian relaxation method,the simulated SM values were obviously improved in desert areas,somewhat improvements also occurred grassland,shrub and grass mixed zones.On temporal scale,the difference between the simulated and observed SM were also decreased. | publication |
171419 | Infrared structural monitoring of cracks using thermoelastic analysis in production environments | This proposal is built around a well-established set of laboratory-based techniques, which use Thermoelastic Stress Analysis (TSA) for characterising strain fields associated with structural features. It is proposed to extend their applicability to aircraft structure tests and to enhance their productivity through the use of automation for data acquisition and processing in an industrial environment. Thermoelastic stress analysis is well-established as a laboratory-based technique and its use for structural analysis , fracture mechanics and damage mechanics has been explored extensively. Most of the work so far has been performed using relatively small test coupons with simple structural features. In the proposed work the aim is to prove the feasibility of applying thermoelastic stress analysis in a structural test environment for detecting stress hotspots. The structural test tools developed will enable fast acquisition of data-rich stress fields in large aerospace components during structural tests at relatively low cost and the post-processing capabilities will allow meaningful comparison of experimental results with those from computational models and service life evaluations. The scientific and technical objectives are designed to lead to innovative methodologies that will enable more detailed stress information to be acquired during aircraft structure tests. These methodologies will be faster, lower cost and provide higher confidence in computational models than is possible at the moment. | project/european |
US 2015/0052727 W | UNDERWATER COMMUNICATION SYSTEMS, UNDERWATER SPEAKERS, UNDERWATER MICROPHONE ASSEMBLIES AND METHODS | Underwater communication systems, underwater speakers, underwater microphone assemblies and associated methods are described. According to one aspect, an underwater speaker includes a housing, a transducer member coupled with the housing and positioned to contact a body of water, wherein the transducer member is configured to vibrate to generate sound pressure waves within the body of water which comprise content which is audible to humans within the body of water, and an exciter coupled with the transducer member and configured to impart forces to the transducer member to cause the vibration of the transducer member to generate the sound pressure waves in the body of water as result of a received electrical signal which comprises the content. | patent |
W2359638483 | Current expression mode of clan's power of discourse——Humanics investigation on establishing ancestral temple and revising pedigree of clans at Heye Town | The activities such as ancestral temple reconstruction and revising pedigree of clans,etc.are substantially the expression mode of clan's power of discourse and an appeal of clan's consciousness after the loss of clan's power of discourse for a long time.This paper takes the Ge's establishment of ancestral temple and revision of pedigree of clans at Heye Town of Hunan Province as an example to expound the process of establishing ancestral temple and revising pedigree of clans,analyze the background and motivating force for revitalizing clan's consciousness,propose that these activities manifest the restoration and reappearance of traditional ethnics.They embody local politics and economic appeal;it is a result of mutual adjustment between a country and civilian power;it is motivated by local knowledge and modern technology;the appeal for pedigree of a clan is a practical problem existed nowadays that should be fully regarded and correctly guided. | publication |
997045 | Smarter finance for families–improving citizens’ health, comfort and financial well-being by supporting banks, residential investors and solution providers with green homes and green mortgage programs | Many citizens, particularly in nascent green building markets, make suboptimal decisions in the design and construction choices for renovation approaches and new home purchases due to a fear of bank financing. Borrowing sufficiently to bring forward necessary resources to build homes properly both reduces citizens’ “Total Cost of Monthly Ownership” (loan payment plus energy, health and repair costs) while unlocking a critical increase of construction budgets facilitating ownership of the greenest, high-quality homes. Financing Green Homes with the borrower subject to lower monthly operating costs is less risky to banks which provide discounted credit without harming profits.
The SMARTER project effectively communicates the benefits of Green Homes to citizens and other key stakeholders to bring a systemic solution to a systemic problem that inhibits the financial industry to design and offer green finance products and the citizens to understand and request them. SMARTER replicates a successful “Green Homes and Green Mortgage” program to 12 new countries, addresses barriers and brings green innovation with relevant research and cluster formation, adapts essential tools for administration and communication, and effectively expands collection of actual energy and financial performance to improve risk analysis with local data. Public investment is leveraged and ambitious green EU targets are supported as banks, developers, and green solution providers all contribute budgets to increase private financing for building exemplary homes.
The SMARTER “Green Homes Investment Platform” guides new programs to a suitably ambitious, common definition of green investments and facilitates institutional investment by collaborating with ongoing initiatives including EeMAP and EEFIG; aligning with EC objectives such as “Mainstreaming Energy Efficiency Finance” and advancing the Financial, Technical and Behavioral de-risking championed by “Smart Finance for Smart Buildings"". | project/european |