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Agentic Health, Inc. 3

https://www.semanticscholar.org/paper/104390d456a7fc770cb1dfe690d8085a39a0de6a

New Appliances and Things Medical

The Hospital

965d752e-3d99-47a6-bf0f-de96ba26b1f3

New Appliances and Things Medical (Hockin, Wilson & Co., 13 to 16 New Inn Yard, 186a Tottenham Court Road, London, W.; also at Manchester.) The sanitary feeding bottle which is manufactured by Messrs. Hockin, Wilson & Co., and is known as the " EverSweet" is a combination of the most highly appreciated improvements which have been effected in this class of bottle. It is a boat-shaped bottle with a flat bottom for standing. It is open at both ends so that it can be flushed through by applying it to the tap. At one end is fixed a most approved variety of rubber nipple, and at the other end is an indiarubber cap which contains a pin hole, and which can therefore act as an efficient valve for the admission of air. The bottle is further graduated in ounces, which are unusually accurate. We commend the "Ever-Sweet" feeding bottle

https://www.semanticscholar.org/paper/5e1cbd52be6463d06b171fde012ed5d178795829

Polyembolokoilamania with obsessive compulsive and related disorders: A case series

Indian Journal of Psychiatry

abb0b27b-530d-4e7d-8bde-7bdb25448cc4

Polyembolokoilamania with obsessive compulsive and related disorders: A case series ABSTRACT Polyembolokoilamania is a condition seen in a medical or surgical emergencies where the person, sometimes repetitively, inserts various foreign bodies through body orifices or skin to obtain gratification often associated with background psychiatric diagnoses. We present three cases where one patient with Obsessive Compulsive Disorder (OCD) presented with urethral polyembolokoilamania, one with Excoriation disorder presented with multiple pin-piercing behavior through the skin and one case of OCD presented with anal polyembolokoilamania. Treatment of the underlying Obsessive-Compulsive and Related Disorders curbed such behaviors successfully in all three cases emphasizing the importance of treating background psychiatric disorders in such conditions.

https://www.semanticscholar.org/paper/b804b39061c2a28b8265e91610ada1575e9d234e

Number of growth days and not length of the growth period determines radial stem growth of temperate trees

Ecology Letters

0ab10a19-5aec-4bd0-ba95-d98d85d33643

Number of growth days and not length of the growth period determines radial stem growth of temperate trees Abstract Radial stem growth dynamics at seasonal resolution are essential to understand how forests respond to climate change. We studied daily radial growth of 160 individuals of seven temperate tree species at 47 sites across Switzerland over 8 years. Growth of all species peaked in the early part of the growth season and commenced shortly before the summer solstice, but with species‐specific seasonal patterns. Day length set a window of opportunity for radial growth. Within this window, the probability of daily growth was constrained particularly by air and soil moisture, resulting in intermittent growth to occur only on 29 to 77 days (30% to 80%) within the growth period. The number of days with growth largely determined annual growth, whereas the growth period length contributed less. We call for accounting for these non‐linear intra‐annual and species‐specific growth dynamics in tree and forest models to reduce uncertainties in predictions under climate change.

https://www.semanticscholar.org/paper/1fd937ee92d75ce81bd4d53f8760e4a1e6482df7

Comparing Outcomes of Banana-Shaped and Straight Cages in Transforaminal Lumbar Interbody Fusion for Lumbar Degenerative Diseases: A Systematic Review and Meta-Analysis

Neurospine

b38d49f5-9e0d-4cd6-a080-adda18e0ae37

Comparing Outcomes of Banana-Shaped and Straight Cages in Transforaminal Lumbar Interbody Fusion for Lumbar Degenerative Diseases: A Systematic Review and Meta-Analysis Objective This meta-analysis aims to refine the understanding of the optimal choice between different cage shapes in transforaminal lumbar interbody fusion (TLIF) by systematically comparing perioperative data, radiological outcomes, clinical results, and complications associated with banana-shaped and straight bullet cages. Methods A meticulous literature search encompassing PubMed, Embase, Scopus, Web of Science, China Knowledge Network, and Wanfang Data was executed up to October 5, 2023. Inclusion criteria focused on studies comparing banana-shaped and straight bullet cages in TLIF. The quality of included studies was assessed using appropriate tools such as the Newcastle-Ottawa Scale (NOS) for nonrandomized studies. Rigorous evaluations were performed for radiographic outcomes, including disc height (DH), segmental lordosis (SL), lumbar lordosis (LL), subsidence, and fusion rates. Clinical outcomes were meticulously evaluated using visual analogue scale (VAS), Oswestry Disability Index (ODI), and complications. Results The analysis incorporated 7 studies, involving 573 patients (297 with banana-shaped cages, 276 with straight cages), all with NOS ratings exceeding 5 stars. No statistically significant differences were observed in operative time, blood loss, or hospitalization between the 2 cage shapes. Banana-shaped cages exhibited greater changes in DH (p = 0.001), SL (p = 0.02), and LL (p = 0.01). Despite statistically higher changes in ODI for straight cages (26.33, p < 0.0001), the actual value remained similar to banana-shaped cages (26.15). Both cage types demonstrated similar efficacy in VAS, complication rates, subsidence, and fusion rates. Conclusion Although banana-shaped cages can excel in restoring DH, SL, and LL, straight bullet cages can provide comparable functional improvements, pain relief, and complication rates.

https://www.semanticscholar.org/paper/320787264d04f711ebe9df5fbe68cc76e1793906

Retracted: Location-Dependent Query Processing: Semantic Cache for Real-Time Smart City Analytics

Applied Bionics and Biomechanics

c13bcfa9-c7a1-4adb-a493-85759a0f4a0a

Retracted: Location-Dependent Query Processing: Semantic Cache for Real-Time Smart City Analytics .

https://www.semanticscholar.org/paper/990f706ac9caf24e78c929ee0ed1b6a1907d497f

Retracted: Application of Isothermal Signal Amplification Technique in the Etiological Diagnosis of Gonorrhea and Drug Resistance Gene Detection

Computational and Mathematical Methods in Medicine

2ca1e2ac-8c3b-4251-94ed-24846d391d3b

Retracted: Application of Isothermal Signal Amplification Technique in the Etiological Diagnosis of Gonorrhea and Drug Resistance Gene Detection .

https://www.semanticscholar.org/paper/8d47af31b003c2c06221d679767ff40d730fa22e

Downregulation of HNRNPM inhibits cell proliferation and migration of hepatocellular carcinoma through MAPK/AKT signaling pathway

Translational Cancer Research

b55a0d7d-c7ea-4b2f-b831-720686cfe687

Downregulation of HNRNPM inhibits cell proliferation and migration of hepatocellular carcinoma through MAPK/AKT signaling pathway Background HNRNPM is reported to be involved in multiple malignancies, while the prognostic and biological role of HNRNPM in hepatocellular carcinoma remains still unknown. Methods Public databases and tissue microarrays were employed to identify the expression pattern and prognostic value of HNRNPM in hepatocellular carcinoma. CCK8, cell migration assays and western blot were taken advantage of to discover the biological role of HNRNPM in hepatocellular carcinoma. Western blot and bioinformatics analysis were used to reveal the potential signaling pathways of HNRNPM in hepatocellular carcinoma. Results High expression of HNRNPM was proved to be a poor independent prognostic factor for overall survival (OS) of hepatocellular carcinoma patients. Tissue microarrays and immunohistochemistry showed that HNRNPM protein level was upregulated in pancreatic cancer tissues compared with normal pancreas. Knockdown of HNRNPM suppressed significantly the capacities of proliferation and migration and alter epithelial mesenchymal transition of hepatocellular carcinoma cells. Downregulation of HNRNPM resulted in inhibition of the MAPK/AKT signaling pathway in hepatocellular carcinoma. Bioinformatics implied that HNRNPM might be a component of spliceosome to participate in hepatocellular carcinoma. Conclusions This paper identified high expression of HNRNPM was a poor independent prognostic factor for OS of hepatocellular carcinoma and could participate in proliferation and migration through MAPK/AKT signaling pathways.

https://www.semanticscholar.org/paper/cf9d8860485aa681e8847a9e9b3be68d56590c9a

Ultrastructural alterations of megakaryocytes in thrombocytopenia: A review of 43 cases

Blood Science

641482b3-d9d2-4795-a45a-a16069fc4391

Ultrastructural alterations of megakaryocytes in thrombocytopenia: A review of 43 cases .

https://www.semanticscholar.org/paper/fe432fc05c27e880771d0b9b3e73ebbfc2f5bfbe

Acute Cholecystitis and Laparoscopic Cholecystectomy

JSLS : Journal of the Society of Laparoendoscopic Surgeons

Acute Cholecystitis and Laparoscopic Cholecystectomy Objective: To determine whether laparoscopic cholecystectomy (LC) should be the procedure of choice in treating acute cholecystitis. Method: A prospective study was conducted over a 4 1/2-year period. There were 187 patients with acute cholecystitis out of 1020 patients with gallbladder disease who required cholecystectomy. These patients were divided into three groups based on the time interval between the onset of pain and the time patients sought medical attention: Group 1, 7 days. All the patients underwent LC after a comprehensive preoperative workup. The parameters analyzed included operating time, hospital stay, and conversion rate. The comparison was made among the various groups and with those who had elective LC. Results: One hundred twenty patients (64.17%) presented for treatment within 3 to 7 days of the onset of an attack. Empyema of the gallbladder was seen in 106 (56.68%) patients and phlegmon of the gallbladder in 42 (22.46%) patients. Group 3 patients had an operative time of 56.2 min as opposed to 18.5 min in Group 1 and 17.5 min in the elective LC group. The conversion rate in Group 3 was 19.5% versus 3.8% in Group 1 and 3.48% in the elective LC group. The complication rate was 7.3% in Group 3, 3.8% in Group 1, and 3.7% in the elective LC group. Conclusion: Acute cholecystitis is better managed by laparoscopic cholecystectomy, except in the patients presenting with a gallbladder phlegmon later than 7 days after the onset of the attack.

https://www.semanticscholar.org/paper/e785ff4f798893272e537f5276e4dfc4172c5d10

Client’s perception toward services of smoking cessation clinics in Riyadh, Saudi Arabia

Journal of Family Medicine and Primary Care

3a3c33b7-3bf1-4cfd-89d7-4f601d9a50a4

Client’s perception toward services of smoking cessation clinics in Riyadh, Saudi Arabia ABSTRACT Background: In Saudi Arabia, approximately 70,000 deaths yearly occur from diseases caused by smoking. Assessing patients’ smoking behavior in primary care has apparent benefits. Assisting patients with smoking cessation is one of the essential roles of primary care. This study evaluated the quality of smoking cessation clinic counseling in Riyadh, Saudi Arabia, based on customer opinions of such services. Methods: This research employed a cross-sectional approach involving individuals attending smoking cessation clinics located within primary health care centers in Riyadh city. The participants were chosen through random selection. They were informed about the study’s objectives, and those who consented to take part were contacted and provided with an online questionnaire to complete. Results: A total of 340 subjects participated (95.6%) of them were males, and 41.2% were in the age group of 25 to 35 years old. The common modality of tobacco use was cigarettes (82.6%), and 87.9% reported consuming tobacco daily. The mean (±SD) total score of the Fagerstrom Test of Nicotine Dependence was 5.03 (±2.36), and the highest percentage (44.4%) of the participants had a moderate level of nicotine dependence. The vast majority (93.8%) of the participants had former quitting experiences. Half (50.9%) of the participants showed complete satisfaction with the cessation clinics, while 13.2% and 9.1% of them were not satisfied or slightly satisfied, respectively. Conclusion: The majority of smoking cessation clinic visitors were satisfied with the services provided, exceeding three-quarters of them, with half totally satisfied.

https://www.semanticscholar.org/paper/434c6fe9f37d9667b7d9bd9f87d652e17d67b58d

White Willow Bark Induced Acute Respiratory Distress Syndrome

North American Journal of Medicine and Science

bf9ccb21-63de-40a0-8513-84efa8b1b7b3

White Willow Bark Induced Acute Respiratory Distress Syndrome Dear Editor, A 61-year-old female with the past medical history of hypertension and osteoarthritis presented to Emergency Department with sudden onset of shortness of breath and non-productive cough 30 min, after taking white willow bark supplement. The patient denied any history of the drug or supplement allergy. Pulse oximetry demonstrated oxygen desaturation; SpO2 of 75% on ambient air and 94% on nasal cannula with the flow of oxygen 20 L/min. Arterial blood gas although on FiO2 of 100% showed severe hypoxemia with the high A-a gradient, metabolic acidosis with respiratory compensation (pH 7.28, PCO2 36 mmHg, PaO2 75 mmHg, and HCO3 19 mmol/L). Blood tests demonstrated evidence of wide anion gap (AG) metabolic acidosis (AG 14 mmol/L) from lactic acidosis (lactic acid 4.9 mmol/L) with the normal gap metabolic acidosis (∆AG/∆Bicarb = 0.4) and the patient had no osmolal gap. Furthermore, serum ketone and salicylate levels were undetectable and her chest X-ray showed bilateral interstitial infiltrates . Transthoracic echocardiogram revealed normal systolic and diastolic function. The diagnosis of acute hypoxic respiratory failure secondary to severe acute respiratory distress syndrome (ARDS) from reaction to white willow bark was made; the PaO2/FiO2 of 75 mmHg. The patient was promptly started on intravenous venous methylprednisolone and oral antihistamines including diphenhydramine and ranitidine. The patient responded well with our treatment and her oxygen requirement gradually improved from 94% on FiO2 of 100% to 95% on room air. Lactic acidosis also subsided after maintaining adequate oxygenation. Figure 1 Chest X-ray demonstrated bilateral interstitial infiltrates The use of white willow bark supplement was first reported back to the time of Hippocrates (400 BC) when patients were advised to chew on the bark for pain relief and fever reduction. Willow bark is also included in weight-loss products. There have been a remarkably small number of reported cases of adverse reactions to willow bark extract. These adverse drug reactions are usually mild (maculopapular rashes). White willow bark induced anaphylaxis is rare; however, a few cases have been reported. To our knowledge, this is the first report of white willow bark induced ARDS. People who are allergic or sensitive to salicylates (such as aspirin) should not use willow bark.

https://www.semanticscholar.org/paper/fc0def609f5a2a822f3f71e5cc2142d53ad75130

Getting started in Bioinformatics

Bioinformation

9fb87cc5-da11-409f-b6d0-bfba215f96a4

Getting started in Bioinformatics Several times a month, people that want to get started in the field of Bioinformatics contact me, looking for a job, a student position or a connection to someone else who has a job or postdoc opening. This is to be expected, perhaps. After the dot-com crash a few years ago, people were leaving the Internet and telecom fields in droves to get retrained. The 'Next Big Thing' that was being hyped at the time was Bioinformatics, and there were many new programs starting up that were available to train them. Now they are finished and want to take the next step. The problem is, that the reality of the Bioinformatics job market does not match the hype of a few years back. There are positions to be had, but also a good deal of competition. How do you separate your resume beyond the usual grade point averages and class rankings? Bioinformatics is a broad field, and beyond the basics there is much less standardization in programs compared to a much more mature field such as Chemistry or physics. The result is that employers frequently don't know what classes you have taken based simply on your degree, and generally do not have the time to investigate more thoroughly. You need a way to convince people that you can really do the job, and solve real-world problems, not merely pass classes. The solution is to do a useful project (or multiple projects) that people will actually use. If you become the person that is known for developing a certain program, then everyone that uses your program will know your name. Even people that have not yet seen your program will be able to download it and see what you can do. Even a clever Perl script or an improvement to an existing program can be beneficial to your career-after all, people will figure that if you can solve some of their computational problems, the probability is pretty high that you will be able to do it again. Now, where will you find the perfect project to work on? Professors, Biotech or Pharma scientists, or anyone you meet at conferences, who is working in an area that interests you. Most of these people have much more work than they can actually accomplish. Ask them what you can do to help them out. They will be much more inclined to talk to you …

https://www.semanticscholar.org/paper/de60d4583b6538da96a3536c0df03fefcba0a762

Socio demographic And Prevalence of Psychiatric Illnesses of Military Personal Admitted in a Non-Military Hospital

Indian Journal of Psychiatry

abb0b27b-530d-4e7d-8bde-7bdb25448cc4

Socio demographic And Prevalence of Psychiatric Illnesses of Military Personal Admitted in a Non-Military Hospital Background: Behavioural issues occur with military person which unit people find as psychiatric illness and not addressed properly by non-psychiatric doctor of military hospital are then referred for evaluation and deciding whether person is fit for current work. Aims: Socio demographic And Prevalence of Psychiatric Illnesses of Military Personal Admitted in a Non-Military Hospital Methodology: We had taken 32 subjects who were admitted after referral from either unit in charge of military troops or medical officer of military hospital for psychiatric evaluation and treatment Results: Most of the cases are Hindu, undergraduate, either unmarried or living separate if married, of constable rank, referred mostly by unit in charge. Most common finding is NAD (no observable defect) followed by schizophrenia and depression. No significant co relation found in socio-demographic and service profile in NAD & those with psychiatric comorbidity Conclusion: Referrals from unit were based upon action of subject viewed as indiscipline and those from medical officer are based on concurrent disease or suspected psychiatric illness. Certain steps should be taken to address stress & psychiatric illness related aspect to military person

https://www.semanticscholar.org/paper/7ce8137b90dc398ad91f201d04af8d053076e22d

Correction: Evaluation of a Virtual Reality Platform to Train Stress Management Skills for a Defense Workforce: Multisite, Mixed Methods Feasibility Study

Journal of Medical Internet Research

2baad992-2268-4c38-9120-e453622f2eeb

Correction: Evaluation of a Virtual Reality Platform to Train Stress Management Skills for a Defense Workforce: Multisite, Mixed Methods Feasibility Study .

https://www.semanticscholar.org/paper/f3ed5abb854aef871432cdb8b40bc333984f7475

Productivity of SCI Korean medical papers: 1996-1997.

Journal of Korean medical science

234eed58-91c0-4682-ac5e-2a86d6d3acdc

Productivity of SCI Korean medical papers: 1996-1997. In order to investigate the extent and growth of SCI publication activity of Korean medicine, DIALOG's SCISearch database was searched and the number of SCI Korean medical papers in each medical specialty was measured by publication year and by document type for 1996 and 1997. The percentage contribution of Korean medical papers to SCI database and the SCI publication productivity ratio were analyzed for each of 57 medical specialties. The data obtained in this study was compared with the data representing the 1980s and the data for the first half of the 1990s. The absolute productivity of SCI Korean medical papers as measured by the number of SCI Korean papers has increased about ten times from 306 papers in 1990 to 3,261 papers in 1997. More than 15% of SCI Korean publication output has resulted from six Korean medical journals indexed in SCI from 1995. The relative productivity of SCI Korean medical papers as measured by the percentage contribution from Korea to SCI and by its corresponding productivity ratio is not as impressive as the absolute productivity and its growth rate. It has increased three times from 0.245% to 0.642% during the same period. The relative productivity of SCI Korean medical publication output is not as great as the SCI Korean publication output of all sciences combined (1.02%).

https://www.semanticscholar.org/paper/165ccdff022fa64b78efd653f4b7b7f8fac2ef75

Mitigating disruption: How corporate boards are prioritizing business resilience during the pandemic

Board Leadership

9fc5db3d-3944-4537-81e4-5b81ea974f6b

Mitigating disruption: How corporate boards are prioritizing business resilience during the pandemic Catherine Allen is the founder and chairman of the Board Risk Committee, a nonprofit organization dedicated to providing a trusted, noncompetitive, peer forum for the exchange of ideas, best practices, and topics of interest. She is also a member of Women Corporate Directors. In this article, she discusses the impact that the COVID‐19 pandemic has had on corporate boards, and some of the ways they've responded to the crisis.

https://www.semanticscholar.org/paper/279e578c06465b3b9bfb4edc61b6bff96a7ef586

Adsorption of lead ions from wastewater using electrospun zeolite/MWCNT nanofibers: kinetics, thermodynamics and modeling study

RSC Advances

0650c289-97b1-4db5-a39d-247ed29f04e3

Adsorption of lead ions from wastewater using electrospun zeolite/MWCNT nanofibers: kinetics, thermodynamics and modeling study Heavy metal contamination in water is a serious environmental issue due to the toxicity of metals like lead. This study developed zeolite and multi-walled carbon nanotube (MWCNT) incorporated polyacrylonitrile (PAN) nanofibers via needleless electrospinning and examined their potential for lead ion adsorption from aqueous solutions. The adsorption process was optimized using response surface methodology (RSM) and artificial neural network (ANN) modeling approaches. The adsorbent displayed efficient lead removal of 84.75% under optimum conditions (adsorbent dose (2.21 g), adsorption time (207 min), temperature (48 °C), and initial concentration (62 ppm)). Kinetic studies revealed that the adsorption followed pseudo-first-order kinetics governed by interparticle diffusion. Isotherm analysis indicated Langmuir monolayer adsorption with improved 5.90 mg g−1 capacity compared to pristine PAN nanofibers. Thermodynamic parameters suggested the adsorption was spontaneous and endothermic. This work demonstrates the promise of electrospun zeolite/MWCNT nanofibers as adsorbents for removing lead from wastewater.

https://www.semanticscholar.org/paper/6d3652b599c677e90d576261e87e611fa26b6973

Review of clinical approaches in fluorescence lifetime imaging ophthalmoscopy (Erratum)

Journal of Biomedical Optics

3a712262-b7d9-4756-94a1-57c2f9d4197c

Review of clinical approaches in fluorescence lifetime imaging ophthalmoscopy (Erratum) Abstract. This erratum corrects an error in “Review of clinical approaches in fluorescence lifetime imaging ophthalmoscopy”

https://www.semanticscholar.org/paper/8151f5d159b711398387dc1c0b92185d7be57cb3

Retraction: The effect of HER-2 polymorphism according to age on the risk and pathologic feature of endometrial cancer

Obstetrics & Gynecology Science

3e6ad3b7-7430-4f43-8bf1-6e164b1dbbba

Retraction: The effect of HER-2 polymorphism according to age on the risk and pathologic feature of endometrial cancer Lee JM, Lee JH, Tong SY, Ki KD, Lee SK, Huh CY. The effect of HER-2 polymorphism according to age on the risk and pathologic feature of endometrial cancer. Korean J Obstet Gynecol 2009;52:529-537. The above article from Korean J Obstet Gynecol, published on May 2009, has been retracted by agreement between the authors, the journal Editor-in-Chief, professor Pil Ryang Lee, and publication office of Korean J Obstet Gynecol. The authors' statement follows below In 2009, we published two articles associated with the effect of HER-2 polymorphism on endometrial cancer. One article appeared in Korean J Obstet Gynecol and the other appeared in BJOG . Specifically, the opening to the readers (including the opening in the online publication) of the two articles are similar. Although the article published in BJOG was designed, written, submitted and accepted earlier, we did not cite the article from BJOG because it had not yet been printed at that time. Thus, in order to make clearance for referencing issue between Korean J Obstet Gynecol and BJOG, we decided to retract the paper published in Korean J Obstet Gynecol. We regret the inadvertent omission of the appropriate referencing and offer sincere apologies to readers for any inconvenience caused by this retraction.

https://www.semanticscholar.org/paper/10e2ea9d601f49b048eed74ff1fa11b7b7e6f6ad

Correction: The Beneficial Effects of Antifreeze Proteins in the Vitrification of Immature Mouse Oocytes

PLoS ONE

0aed7a40-85f3-4c66-9e1b-c1556c57001b

Correction: The Beneficial Effects of Antifreeze Proteins in the Vitrification of Immature Mouse Oocytes Figure 2 is incorrect. The correct version of Figure 2 can be viewed here:

https://www.semanticscholar.org/paper/5fbc6474a402f57bdf7473ae93cf533faf4e6ce8

William Robertson

Edinburgh medical journal

befe79e7-4edb-4281-9c6b-d16dbe123330

William Robertson m.d. of Glasgow in 1891 and the d.p.h. in 1893. His first Public Health appointment was in Perth and he was also medical officer to the Burgh of Auchterarder. Then he transferred to Paisley, where his energetic administration succeeded in stamping out the recurrent epidemics of typhoid which attacked that town. In 1904 Dr Robertson was appointed M.O.H. to the Port of Leith, where, amongst other things, he had to deal with small epidemics of smallpox and plague in the crews of foreign ships. When the boundaries of Edinburgh were extended, Dr Robertson became deputy M.O.H. for the city

https://www.semanticscholar.org/paper/6f8dcc8c14fd3d9febfa2b88468d707c2b8aace5

The CoREST repressor complex mediates phenotype switching and therapy resistance in melanoma

Journal of Clinical Investigation

8c9a9e1b-acf2-4274-8d73-6ea0ecd11fd1

The CoREST repressor complex mediates phenotype switching and therapy resistance in melanoma Virtually all patients with BRAF-mutant melanoma develop resistance to MAPK inhibitors largely through nonmutational events. Although the epigenetic landscape is shown to be altered in therapy-resistant melanomas and other cancers, a specific targetable epigenetic mechanism has not been validated. Here, we evaluated the corepressor for element 1–silencing transcription factor (CoREST) epigenetic repressor complex and the recently developed bivalent inhibitor corin within the context of melanoma phenotype plasticity and therapeutic resistance. We found that CoREST was a critical mediator of the major distinct melanoma phenotypes and that corin treatment of melanoma cells led to phenotype reprogramming. Global assessment of transcript and chromatin changes conferred by corin revealed specific effects on histone marks connected to epithelial-mesenchymal transition–associated (EMT-associated) transcription factors and the dual-specificity phosphatases (DUSPs). Remarkably, treatment of BRAF inhibitor–resistant (BRAFi-R) melanomas with corin promoted resensitization to BRAFi therapy. DUSP1 was consistently downregulated in BRAFi-R melanomas, which was reversed by corin treatment and associated with inhibition of p38 MAPK activity and resensitization to BRAFi therapies. Moreover, this activity was recapitulated by the p38 MAPK inhibitor BIRB 796. These findings identify the CoREST repressor complex as a central mediator of melanoma phenotype plasticity and resistance to targeted therapy and suggest that CoREST inhibitors may prove beneficial for patients with BRAFi-resistant melanoma.

https://www.semanticscholar.org/paper/c5629c96bd8d00de78d41fcc214c5e87872b4bee

Nobel prize in physiology or medicine by the Indian medical education system: How far and how close?

Journal of Family Medicine and Primary Care

3a3c33b7-3bf1-4cfd-89d7-4f601d9a50a4

Nobel prize in physiology or medicine by the Indian medical education system: How far and how close? ABSTRACT Every year, Nobel prizes are announced, recognizing the unique contributions of individuals and organizations across the globe. Currently, India hosts the largest medical education system in the world with 650 medical colleges spread all over India and capacity to train 100,000 MBBS medical doctors a year. India is also a hub of cost-effective pharmaceutical industries and dubbed as the ‘pharmacy of the world’. However, the cost of care is still out of reach of a large section of the population. If India is to become a global economic power, such aspirations cannot be solely based on the consumer market-driven economy but on achieving supremacy in ‘new knowledge’ creation as well. The research capacity needs to be optimized and capable of translating research work into the domestic monopoly and control over newer knowledge, technologies, products, and services for global consumers. Cost of care for more than 1 billion people, even if it is through universal health coverage, can be significantly reduced by supporting research activities and creating domestic intellectual properties in the healthcare sector.

https://www.semanticscholar.org/paper/d819399552736f051fdadb2a3031f15a83646bcf

Coenzyme Q10: The essential nutrient

Journal of Pharmacy and Bioallied Sciences

78f0693c-2254-425e-9816-0af30e467821

Coenzyme Q10: The essential nutrient This study shows that in 28% negative studies, the conclusions are incorrect as insignificant P values are used to prove null hypothesis, which is incorrect. This incorrect conclusion shows the poor knowledge of research methodology of not only the researchers but also the peer reviewers and editors of the journals. If investigators are interested in testing equivalence of interventions, different study designs, for example, studies with a non-inferiority design, should be used. This study highlights the importance of adequate reporting of various parameters in published studies which can be useful in checking the validity of the study. The issues of underreporting of these parameters are already explored in a few studies done for western and Indian journals. This article highlights the importance of statistical review of submitted manuscripts. All manuscripts should be sent for statistical review and every journal should have a statistical editor. It is possible that conclusions of such articles become the basis for the application of one intervention at the place of another. To avoid this, readers who identify such wrong conclusions in articles should write a letter to the editor of the respective journal in order to communicate such errors to other readers.

https://www.semanticscholar.org/paper/00cca57c2d0f5fa7c520efaf6bbbf1ee54dc8df7

Impact of Rapid Identification and Stewardship Intervention on Coagulase-Negative Staphylococcus Bloodstream Infection

Open Forum Infectious Diseases

f20432ac-3c14-4779-bc66-2f24e1b2715e

Impact of Rapid Identification and Stewardship Intervention on Coagulase-Negative Staphylococcus Bloodstream Infection Abstract We investigated the impact of rapid diagnostic testing with and without algorithm-based stewardship recommendations on antibiotic use for bloodstream infection with coagulase-negative staphylococci. A significant reduction in antibiotic days of therapy was achieved in the stewardship intervention group that was not seen with rapid diagnostic testing alone.

https://www.semanticscholar.org/paper/2f6bc361ecc13079f736a3c314ff6e3fa12cd414

Hurronath Roy's Midwife's Vade-Mecum

The Indian medical gazette

7bc8c601-4efa-400f-972e-164343190429

Hurronath Roy's Midwife's Vade-Mecum of out* medical schools, for students of the homoeopathic school of medicine, for general practitioners, for heads of families, and even for pregnant women, who by its perusal ma)' be able to dispense with medical aid at the most critical period of their existence. Then, it is stated, that it is not only a compilation from old and recent English authors, but some entirely new matters have been added from an experience of nearly a quarter of a century, from the Hindu system of medicine, and from reasonable customs and practices of the country. Books rational and homoeopathic have been con-

https://www.semanticscholar.org/paper/6e7385f29bfcb1743855056021ee409cfb14e32a

From COVID Vaccines to HIV Prevention: Pharmaceutical Financing and Distribution for the Public’s Health

Journal of Law, Medicine & Ethics

1b9aaae7-9e1e-4dd3-a6df-bface6486e16

From COVID Vaccines to HIV Prevention: Pharmaceutical Financing and Distribution for the Public’s Health Abstract The complexity and inefficiency of the U.S. health care system complicates the distribution of life-saving medical technologies. When the public health is at stake, however, there are alternatives. The proposal for a national PrEP program published in this issue of the Journal applies some of the lessons of the national COVID vaccine campaign to HIV prevention. In doing so, it draws on other examples of public health approaches to the financing of medical technology, from vaccines for children to hepatitis C treatment.

https://www.semanticscholar.org/paper/13e98ffc04c1df71c0bdf0ece78cd12455c08b1c

Corrigendum: (-)-T-Cadinol, a Sesquiterpene Isolated From Casearia sylvestris (Salicaceae)—Displayed In Vitro Activity and Causes Hyperpolarization of the Membrane Potential of Trypanosoma cruzi

Frontiers in Pharmacology

84a6a8b4-8e85-48bd-b65e-a83d83f95908

Corrigendum: (-)-T-Cadinol, a Sesquiterpene Isolated From Casearia sylvestris (Salicaceae)—Displayed In Vitro Activity and Causes Hyperpolarization of the Membrane Potential of Trypanosoma cruzi .

https://www.semanticscholar.org/paper/9fc4971871b149dd98a2a06ce6d6b93937d5ea0a

Underprescribing vs underfilling to oral anticoagulation: An analysis of linked medical record and claims data for a nationwide sample of patients with atrial fibrillation

Journal of Managed Care & Specialty Pharmacy

e643cabd-9ed7-4c4c-b50d-6676b70d02e8

Underprescribing vs underfilling to oral anticoagulation: An analysis of linked medical record and claims data for a nationwide sample of patients with atrial fibrillation BACKGROUND: Oral anticoagulants (OAC) is indicated for stroke prevention in patients with atrial fibrillation (AF) with a moderate or high risk of stroke. Despite the benefits of stroke prevention, only 50%-60% of Americans with nonvalvular AF and a moderate or high risk of stroke receive OAC medication. OBJECTIVE: To understand the extent to which low OAC use by patients with AF is attributed to underprescribing or underfilling once the medication is prescribed. METHODS: This is a retrospective cohort study that used linked claims data and electronic health records from Optum Integrated data. Participants were adults (aged ≥ 18 years) with first AF between January 2013 and June 2017. The outcomes included (1) being prescribed OACs within 180 days of AF diagnosis or not and (2) filling an OAC prescription or not among patients with AF who were prescribed an OAC within 150 days of AF diagnosis. Multivariable logistic regression models were constructed to determine factors associated with underprescribing and underfilling. RESULTS: Of the 6,141 individuals in the study cohort, 51% were not prescribed OACs within 6 months of their AF diagnosis. Of the 2,956 patients who were prescribed, 19% did not fill it at the pharmacy. In the final adjusted model, younger age, location (Northeast and South), a low CHA2DS2-VASc score, and a high HAS-BLED score were associated with a lower likelihood of being prescribed OACs. Among patients who were prescribed, Medicare enrollment (odds ratio = 2.2 ) and having a direct oral anticoagulant prescription (1.5 ) were associated with a lower likelihood of filling the prescription. CONCLUSIONS: Both underprescribing and underfilling are major drivers of low OAC use among patients with AF, and solutions to increase OAC use must address both prescribing and filling.

https://www.semanticscholar.org/paper/371001c0a64015c1b753e58bb247baad069a132c

Retracted: Multiomics Analysis of Genetics and Epigenetics Reveals Pathogenesis and Therapeutic Targets for Atrial Fibrillation

BioMed Research International

c52375db-5573-406f-a12b-854c7ba98498

Retracted: Multiomics Analysis of Genetics and Epigenetics Reveals Pathogenesis and Therapeutic Targets for Atrial Fibrillation .

https://www.semanticscholar.org/paper/d1dd1ee6b219686cb318518cddec78234aeec030

Prevalence of hypothyroidism in nondiabetic chronic kidney disease and effect of thyroxine replacement on estimated glomerular filtration rate

Indian Journal of Nephrology

106891df-6256-4f48-a28d-200a6eb5b53b

Prevalence of hypothyroidism in nondiabetic chronic kidney disease and effect of thyroxine replacement on estimated glomerular filtration rate Reduced T3 and free T4, elevated thyroid stimulating hormone, and hyporesponsiveness to thyrotropin releasing hormone raise questions about the presence of hypothyroidism in chronic kidney disease (CKD) and raise the possibility of benefit from thyroxine supplementation. A prospective cohort study was conducted on 73 nondiabetic CKD cases. Hypothyroid patients were started on levothyroxine and were reviewed after 3 and 6 months. The mean age of study population was 42.3 ± 16.8 years. Of the total population, 32 (43.8%) cases had hypothyroidism, among whom 2 (2.7%) had overt hypothyroidism and 30 (41.1%) had subclinical hypothyroidism. Prevalence of hypothyroidism increased with increasing severity of CKD. There were 1 (3.1%) case with hypothyroidism in stage 3b, 8 (25%) cases in stage 4, and 23 (71.9%) cases in stage 5. The mean estimated glomerular filtration rate (ml/min/1.73 m2) at baseline was 13.7 ± 8.9 which increased to 17.5 ± 6.8 and 22.4 ± 9.3 after 3 and 6 months of thyroid hormone replacement therapy (THRT), respectively (P < 0.001). Hypothyroidism is commonly associated with nondiabetic CKD and its prevalence increases with declining renal function. THRT significantly improves renal function in nondiabetic CKD with hypothyroidism.

https://www.semanticscholar.org/paper/ef1c32ea6ce1260fe697f536c2a7708157e9f0ea

Clinical correlates of lithium response in patients with bipolar disorder on long-term lithium therapy

Indian Journal of Psychiatry

abb0b27b-530d-4e7d-8bde-7bdb25448cc4

Clinical correlates of lithium response in patients with bipolar disorder on long-term lithium therapy Background: Lithium continues to be one of first-line prophylactic agents for bipolar disorder (BD) but only about one-third of patients are excellent responders. Studies have described various clinical correlates of treatment response but Indian literature is limited. Aim: to assess the relationship of clinical variables to lithium response in subjects with BD on long-term prophylaxis Methodology: This was a cross-sectional, observational study of 40 subjects, aged 18-60 years, with DSM-5 BD type I, currently in remission. Subjects were included if they were on regular and long-term lithium for atleast one year or more. All subjects were screened using MINI 7.0 to exclude co morbidities and standard scales (YMRS≤4, HAM-D<8) to establish euthymia. Subjects were assessed using clinical proforma, NIMH Life Chart Method, Alda Lithium Response Scale (LRS) and IGSLI scale for typical/atypical features. Results: Mean age for sample was 38.28 ±10.41 years (72.5% males). Mean illness duration was 13.84±9.23 years, with average onset at 24.40±8.21 years. Mean duration on lithium was 5.49±4.11 years (1-18 years) The LRS total (A-B) score showed a significant positive correlation to IGSLI typical features score (p=0.003), time since remission (p=0.034) and a significant negative correlation to IGSLI atypical features score (p=0.019) and age of onset of BD (p=0.037). There was a trend towards poorer lithium response with higher BMI (p=0.052) Conclusion: The clinical course characterized by an early age of onset and more atypical features (via. more manic than depressive episodes, presence of residual symptoms, mood incongruent psychotic features) appear to respond poorer to lithium.

https://www.semanticscholar.org/paper/85173b08092393c6e70458505f8798c7c9335b8a

Drugs and the Young Law Breaker

Mental health

Drugs and the Young Law Breaker The link between drug-taking or alcoholism and crime is not a myth. Sometimes a youth may take drugs to give him Dutch courage to do some housebreaking, addicts forge prescriptions to obtain more drugs, take to prostitution to pay for them, and drug 'pushers' break into chemists to obtain supplies for sale to addicts. Heavy drinking is a complication in the lives of a third of adult prisoners. Dr T. C. N. Gibbens* surveys these manifest links. The last five or ten years have seen a great increase in the use of drugs by teenagers, who come before the courts for delinquency or as beyond control. The most popular drugs are varieties of amphetamine (benze-drine, dexedrine, 'purple hearts', and pep pills). The pattern of consumption of these drugs is fairly characteristic. They are taken at the weekends , to keep awake and save precious hours for dancing and talking all Friday and Saturday night. Many never go beyond this, but others oversleep on Monday, lose their jobs, quarrel with their parents, run away, and so come to court because they are beyond control, or for committing some offence. The minority, who have trying home situations or periodic depressive moods, find that they can keep depression at bay with these drugs and they take them throughout the week, suffering a 'let down' when they wear off, so that they must take more. In this way, they become dangerously dependent on the drug and begin to suffer from overdoses. A remarkable feature of this teenage consumption is the almost universal overdosage. Instead of one or two tablets, they take 20 or 30 in a night. Some wayward girls will swallow any collection of tablets put in their hand, without the least enquiry about the effects or dosage?a price we pay for the great safety limit of modern drugs. With these doses, they are liable to suffer from 'the horrors'?a transitory psychosis with fleeting hallucinations, fears, and ideas of persecution. There have been quite pointless murders carried out in this state of fear and misapprehension and fights and quarrels with parents or the police are quite common. Women offenders Nowadays, about 20 to 25 per cent of boys or girls admitted to remand homes for offences or those in moral danger have been recently taking ampheta-mines, and for a few days they cause considerable difficulty with their outbursts of irritability, aggressiveness and moodiness. …

https://www.semanticscholar.org/paper/10808258615b4b91b434af07fa41bc42434d1d0d

Outcomes of bowel program in spinal cord injury patients with neurogenic bowel dysfunction

Neural Regeneration Research

18b45ae1-2727-4c68-afd1-a9c56e174c48

Outcomes of bowel program in spinal cord injury patients with neurogenic bowel dysfunction In this study, we aimed to determine gastrointestinal problems associated with neurogenic bowel dysfunction in spinal cord injury patients and to assess the efficacy of bowel program on gastrointestinal problems and the severity of neurogenic bowel dysfunction. Fifty-five spinal cord injury patients were included in this study. A bowel program according to the characteristics of neurogenic bowel dysfunction was performed for each patient. Before and after bowel program, gastrointestinal problems (constipation, difficult intestinal evacuation, incontinence, abdominal pain, abdominal distension, loss of appetite, hemorrhoids, rectal bleeding and gastrointestinal induced autonomic dysreflexia) and bowel evacuation methods (digital stimulation, oral medication, suppositories, abdominal massage, Valsalva maneuver and manual evacuation) were determined. Neurogenic bowel dysfunction score was used to assess the severity of neurogenic bowel dysfunction. At least one gastrointestinal problem was identified in 44 (80%) of the 55 patients before bowel program. Constipation (56%, 31/55) and incontinence (42%, 23/55) were the most common gastrointestinal problems. Digital rectal stimulation was the most common method for bowel evacuation, both before (76%, 42/55) and after (73%, 40/55) bowel program. Oral medication, enema and manual evacuation application rates were significantly decreased and constipation, difficult intestinal evacuation, abdominal distention, and abdominal pain rates were significantly reduced after bowel program. In addition, mean neurogenic bowel dysfunction score was decreased after bowel program. An effective bowel program decreases the severity of neurogenic bowel dysfunction and reduces associated gastrointestinal problems in patients with spinal cord injury.

https://www.semanticscholar.org/paper/02234e5c4933e214ee61f77df5934f00228bc0d0

Medical News

The Indian medical gazette

7bc8c601-4efa-400f-972e-164343190429

Medical News Lushai Medical News.?The health of the garrison here find at Luugleh has been fairly good, after the first burst of sickness passed over. The detachment of the 2nd Gurkhas, under Captain Hutchinson, will be relieved by 200 men of the 2nd and 3rd Gurkhas about the end of the month. The Lu&hais appear to have fully realized the advantages of medical attendance free, and Surgeon Moir has always several patients, mostly eye cases.

https://www.semanticscholar.org/paper/80a41e08863dcecdcf78a494d131be88b1dcf564

Correction: Molecular Networks of Human Muscle Adaptation to Exercise and Age

PLoS Genetics

22203759-0bc9-4429-8b67-4140ab209cef

Correction: Molecular Networks of Human Muscle Adaptation to Exercise and Age For the avoidance of any misunderstanding on competing interests, the authors declare that Jamie Timmons is a Founding Director and Thomas Gustafsson, Steen Knudsen and Bethan Phillips are share holders at XR Genomics, a Personalised Health and Fitness company. This should have been indicated at the time of publication. No agreements were in place concerning the execution or publication of this work. The other authors have no competing interests to declare.

https://www.semanticscholar.org/paper/c19ffbca0d2534e5e2ce78544c482db52c7c4502

Correlation of mast cells in periodontal diseases

Journal of Indian Society of Periodontology

8c7575fd-6f5a-484f-a247-3cbd44f72c79

Correlation of mast cells in periodontal diseases Background: Among the cells involved in immune and inflammatory responses in periodontal disease, mast cells have been shown to be capable of generating a large number of biologically active substances. Mast cells are mobile, bone-marrow-derived, granule-containing immune cells that are found in all connective tissue and mucosal environments and in the peripheral and central nervous systems. Mast cells are able to phagocytose, process and present antigens as effectively as macrophages. The present study was undertaken to quantify the mast cells in health and disease, whether they correlate degree of inflammation and clinical features of periodontium. Materials and Methods: Ten cases of localized chronic periodontitis (CP), 10 cases of dental plaque-induced gingivitis (DPIG) and 10 cases of clinically healthy gingival tissues were selected. Samples were obtained from patients undergoing for periodontal surgery in CP and DPIG. In health group third molar impacted and covered with operculum without any inflammation were selected. Sample fixed in 10% buffered formalin and stained with Toludine blue stain and observed under binocular microscope. Conclusion: In human periodontal disease there is an increase in the number of mast cells that may be participating either in the destructive events or in the defense mechanism of periodontal disease via secretion of cytokines.

https://www.semanticscholar.org/paper/22f0e5a5c83fb0b46a20f5c9aed6f188b7a31792

Osteoid Osteoma Mimicking Inflammatory Synovitis

Indian Journal of Nuclear Medicine

71576d28-ad6e-4140-8387-29e01fef3b1c

Osteoid Osteoma Mimicking Inflammatory Synovitis Osteoid osteoma is a common benign bone tumor of unknown etiology affecting the young adult with characteristic clinical and radiographic presentation in its common locations. However, when it arises in unusual intra-articular locations diagnosis may be misleading, often mimicking other entities leading to delayed management. We present a case series of three cases with intra-articular osteoid osteoma that were diagnosed with the help of correlative imaging.

https://www.semanticscholar.org/paper/9fff928d6fde4f5902ad2c4fcffc2ce3eb190b08

In Bae Yoon, an Inventor and Pioneer in Laparoscopic Surgery

Yonsei medical journal

b370fdaf-f63e-4696-94f0-52f58469ce85

In Bae Yoon, an Inventor and Pioneer in Laparoscopic Surgery www.eymj.org Dr. In Bae Yoon (1936–2014) was a prolific inventor and physician who made great contributions to the advancement of gynecologic surgery in South Korea. He was granted 226 U.S. patents and 22 international patents during his lifetime. He passed away on December 30, 2014 at his home in Elliot City, Maryland and will be revered and missed by not only his family, but also the doctors and scientific scholars in the field of medicine who will remember him as a passionate, dedicated man who strived to expand the boundaries of reality to those of dreams.

https://www.semanticscholar.org/paper/f73ce86431e10fe5975b5be159d9c412170c909a

Response to comment on: Culture-positive unilateral panophthalmitis in a serology-2 positive case of dengue hemorrhagic fever

Indian Journal of Ophthalmology

2bbc1e45-4074-471d-b003-2c8f5a99cdb0

Response to comment on: Culture-positive unilateral panophthalmitis in a serology-2 positive case of dengue hemorrhagic fever This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. Cite this article as: Gupta C, Agarwal M, Singh S, Mayor R, Koundanya VV. Comment on: Culture-positive unilateral panophthalmitis in a serology-2 positive case of dengue hemorrhagic fever. Indian J Ophthalmol 2018;66:1660-1.

https://www.semanticscholar.org/paper/02ff9f5357a4ba318b0f2fca5108c31cbb8e4024

Relationship of microsatellite instability to mismatch repair deficiency in malignant tumors of dogs

Journal of Veterinary Internal Medicine

d9f5053c-a9db-4874-9131-2d2e304206cc

Relationship of microsatellite instability to mismatch repair deficiency in malignant tumors of dogs Abstract Background Microsatellite instability (MSI) is a type of genomic instability caused by mismatch repair deficiency (dMMR) in tumors. Studies on dMMR/MSI are limited, and the relationship between dMMR and MSI is unknown in tumors of dogs. Objectives We aimed to identify the frequency of dMMR/MSI by tumor type and evaluate the relationship between dMMR and MSI in tumors of dogs. Animals In total, 101 dogs with 11 types of malignant tumors were included. Methods We extracted DNA from fresh normal and tumor tissues. Twelve microsatellite loci from both normal and tumor DNA were amplified by PCR and detected by capillary electrophoresis. Each microsatellite (MS) was defined as MSI if a difference in product size between the tumor and normal DNA was detected. The dMMR was evaluated by immunohistochemistry with formalin‐fixed paraffin‐embedded tumor tissues. Next, we confirmed whether dMMR induces MSI by serial passaging of MMR gene knockout cell lines for 3 months. Results Microsatellite instability was detected frequently in oral malignant melanoma. The number of MSI‐positive markers was higher in cases with dMMR than in those with proficient MMR (P < .0001). Statistical analysis indicated that the occurrence of MSI in FH2305 might have relevance to dMMR. Furthermore, MSI occurred in dMMR cell lines 3 months after passaging. Conclusions and Clinical Importance Microsatellite instability and dMMR more frequently were found in oral malignant melanoma than in other tumors, and dMMR has relevance to MSI in both clinical cases and cell lines.

https://www.semanticscholar.org/paper/c31a56c1414b5e6f4cb2a1beb5240373616390f8

TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance

Journal of Experimental Medicine

7d071626-1aa2-4dad-a259-bcccedccf44d

TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance TLR9 displays an important early tolerogenic function essential for central B cell tolerance, and CXCL4 inhibits TLR9 function in B cells from SSc patients by sequestering TLR9 ligands away from endosomal TLR9, leading to autoreactive B cell and autoantibody production.

https://www.semanticscholar.org/paper/d08b6a689155609e38dd68133c3baffffe34b57a

The Association of Retinal Microvasculature With Gray Matter Changes and Structural Covariance Network: A Voxel-Based Morphometry Study

Investigative Ophthalmology and Visual Science

e52aeb8d-b929-43a2-b584-f0f5fbcfd9f4

The Association of Retinal Microvasculature With Gray Matter Changes and Structural Covariance Network: A Voxel-Based Morphometry Study Purpose Increasing evidence suggests that retinal microvasculature may reflect global cerebral atrophy. However, little is known about the relation of retinal microvasculature with specific brain regions and brain networks. Therefore, we aimed to unravel the association of retinal microvasculature with gray matter changes and structural covariance network using a voxel-based morphometry (VBM) analysis. Methods One hundred and forty-four volunteers without previously known neurological diseases were recruited from West China Hospital, Sichuan University between April 1, 2021, and December 31, 2021. Retinal microvasculature of superficial vascular plexus (SVP), intermediate capillary plexus (ICP), and deep capillary plexus (DCP) were measured by optical coherence tomography angiography using an automatic segmentation. The VBM and structural covariance network analyses were applied to process brain magnetic resonance imaging (MRI) images. The associations of retinal microvasculature with voxel-wise gray matter volumes and structural covariance network were assessed by linear regression models. Results In the study, 137 participants (mean age = 59.72 years, 37.2% men) were included for the final analysis. Reduced perfusion in SVP was significantly associated with reduced voxel-wise gray matter volumes of the brain regions including the insula, putamen, occipital, frontal, and temporal lobes, all of which were located in the anterior part of the brain supplied by internal carotid artery, except the occipital lobe. In addition, these regions were also involved in visual processing and cognitive impairment (such as left inferior occipital gyrus, left lingual gyrus, and right parahippocampal gyrus). In regard to the structural covariance, the perfusions in SVP were positively related to the structural covariance of the left lingual gyrus seed with the left middle occipital gyrus, the right middle occipital gyrus, and the left middle frontal gyrus. Conclusions Poor perfusion in SVP was correlated with reduced voxel-wise gray matter volumes and structural covariance networks in regions related to visual processing and cognitive impairment. It suggests that retinal microvasculature may offer a window to identify aging related cerebral alterations.

https://www.semanticscholar.org/paper/e69d180892279f385cf36b84f932abe879249d7c

Quality of life in patients of obsessive compulsive disorder: A cross sectional study

Indian Journal of Psychiatry

abb0b27b-530d-4e7d-8bde-7bdb25448cc4

Quality of life in patients of obsessive compulsive disorder: A cross sectional study Introduction: Obsessive Compulsive Disorder(OCD) is a neurotic disorder characterized by recurring, intrusive, anxiety-provoking thoughts or images (obsessions) associated with repetitive, physical or mental rituals (compulsions) aimed at relieving anxiety. Its been found to be linked to poorer adaptive functioning and a poorer response to treatment. Despite recognition that adaptive functioning may be poor in significant proportion of patients,relationship between symptom severity and functioning is not well studied. AIM: To find correlation between symptom severity and global assessment of functioning. Method and methods: This is a cross-sectional, single point assessment study, including 78 patients aged 18 to 60 years, visiting outdoor department of Era's Lucknow Medical College. Cases having OCD according to ICD 10 criteria were included in the study. Those patients were excluded who were having some other psychiatric illness prior to the onset of obsessive compulsive disorder, patients diagnosed with medical and surgical illness requiring immediate intervention, those diagnosed with mental retardation and those not willing to give informed consent. YBOCS was applied to assess symptom severity while GAF was used to assess functioning in these patients. Result and conclusion: We found that symptom severity correlated with the global assessment of functioning. As severity increased it was seen that functioning of patients decline. Statistical data will be presented during the conference.

https://www.semanticscholar.org/paper/8e69b5d8fb429d69755c4f118a19d5f96173f23f

Inactivated SARS-CoV-2 vaccine does not increase the risk of relapse in patients with clinically inactive adult-onset Still’s disease

Rheumatology

4f242814-09d1-4320-b225-b4c9b7872311

Inactivated SARS-CoV-2 vaccine does not increase the risk of relapse in patients with clinically inactive adult-onset Still’s disease Abstract Objective A succession of cases have reported flares of adult-onset Still’s disease (AOSD) after vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), raising concerns. We aimed to investigate the impact of inactivated SARS-CoV-2 vaccines on disease activity in patients with AOSD. Methods We prospectively enrolled clinically inactive AOSD patients visiting the outpatient clinics of our department. The patients received SARS-CoV-2 vaccines (BBIBPCorV, Sinopharm, Beijing, China) voluntarily. The occurrence of relapse in the participants was recorded during the follow-up period and a propensity score matching (PSM) method was used to compare the relapse rates between vaccinated and unvaccinated patients. Localized and systemic symptoms were assessed in the vaccinated patients. Results A total of 122 patients with inactive AOSD were included, of which 49.2% (n = 60) voluntarily received the inactivated SARS-CoV-2 vaccine. The relapse rate did not increase significantly in vaccinated patients in comparison with unvaccinated patients (after PSM: 6.8% versus 6.8%), and no relapse occurred within one month after vaccination. No obvious adverse reactions were reported in 75.0% of the participants, and none of the patients reported severe reactions. Conclusion Increased disease activity or relapse following vaccination with inactivated SARS–CoV-2 were rare in patients with inactive AOSD. Local and systemic adverse reactions were found to be mild and self-limiting. These safety profiles of inactivated SARS–CoV-2 vaccines in patients with AOSD may assist in eliminating vaccine hesitancy and increase the vaccination rate against SARS-CoV-2.

https://www.semanticscholar.org/paper/350aa2911df63e7a771bb37fb79d481f64854a02

Pulmonary Regurgitation after Tetralogy of Fallot Repair: A Diagnostic and Therapeutic Challenge

Journal of Cardiovascular Echography

a256e868-f5b1-4de4-81ca-f797c9531d8a

Pulmonary Regurgitation after Tetralogy of Fallot Repair: A Diagnostic and Therapeutic Challenge Background: Pulmonary regurgitation is the key hemodynamically significant lesion in repaired tetralogy of Fallot contributing to progressive right ventricular (RV) dilatation and biventricular dysfunction. The timing for pulmonary valve replacement remains a controversial topic, and the decision to intervene depends on assessment of RV size and RV function. Objectives: This review aims to discuss the echocardiographic techniques that can be used to assess patients with pulmonary regurgitation after the repair of tetralogy of Fallot defect. While cardiac magnetic resonance (CMR) imaging is the clinical reference method, there is an important role of echocardiography in identifying patients with significant pulmonary regurgitation and assessing the RV size and function. The different echocardiographic techniques that can be used in this context are discussed. Newer techniques for assessing RV size and function include three-dimensional (3D) echocardiography, tissue Doppler and strain imaging. 3D RV volumetric reconstruction based on two-dimensional imaging is a promising new technique that could potentially replace CMR for RV volumetric assessment. Conclusions: Developments in echocardiographic techniques provide new insights into the impact of pulmonary regurgitation on RV structure and function. Echocardiography and CMR are complementary modalities and further research is required to define the optimal use of both techniques for this indication.

https://www.semanticscholar.org/paper/fd1567d9315d8bf2d61a61329fc7504884bb00f0

Efficacy of Intravitreal Bevacizumab for the Treatment of Zone I Type 1 Retinopathy of Prematurity

Journal of Ophthalmic & Vision Research

e8150879-2277-44f1-b34c-1c77ac4d9c4b

Efficacy of Intravitreal Bevacizumab for the Treatment of Zone I Type 1 Retinopathy of Prematurity Purpose: To describe the efficacy of intravitreal bevacizumab for the treatment of type 1 retinopathy of prematurity (ROP) in zone I. Methods: Preterm infants with type 1 ROP in zone I (zone I ROP, any stage with plus disease or zone I ROP, stage 3 without plus disease) were enrolled in this prospective study. Intravitreal bevacizumab (0.625 mg/0.025 ml) was injected under topical anesthesia. Patients were followed weekly for 4 weeks and then biweekly till 90 weeks gestational age. Results: Seventy eyes of 35 patients with type 1 ROP in zone I were enrolled. At a gestational age of 90 weeks, ROP regressed with complete or near-complete peripheral retinal vascularization, in 82.9% of eyes after a single injection and in 92.9% of eyes after up to two injections. In five eyes (7.1%), ROP progressed to stage 4B or 5, so surgical management was required. There were no major complications such as endophthalmitis, cataract, or vitreous hemorrhage after injection. Conclusion: Intravitreal bevacizumab injection is an effective method for the management of patients with Zone I ROP requiring treatment; however, some cases may progress to more advanced stages and require surgical management. Close monitoring for recurrence or progression is necessary. Eyes with persistent zone I ROP may progress to advanced stages when treated with intravitreal bevacizumab injection and re-treatment may be needed.

https://www.semanticscholar.org/paper/02deb63ebad78cac3a80c8fa76c5c282e7b3fa72

MON-628 Noninvasive Encapsulated Papillary RAS-Like Thyroid Tumor (NEPRAS) as a Possible Novel Subtype of Borderline Tumor

Journal of the Endocrine Society

ccbeb193-d73e-4c27-9e78-65553fb9c08a

MON-628 Noninvasive Encapsulated Papillary RAS-Like Thyroid Tumor (NEPRAS) as a Possible Novel Subtype of Borderline Tumor Abstract Background: A subset of thyroid tumors was classified into borderline/precursor tumors in the latest World Health Organization (WHO) classification. However, these tumors were defined only in terms of follicular structure, including hyalinizing trabecular tumor (HTT), noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), and uncertain malignant potential (UMP). As papillary microcarcinoma was proposed to be renamed to papillary microtumor (PMiT), there would be no reasons for restricting borderline/precursor tumors to the follicular growth pattern. Clinical Case: A 26-year-old man was incidentally found to have a 23 mm nodule in his thyroid. After undergoing left lobectomy, histological findings revealed extremely delicate nuclear changes in a noninvasive encapsulated papillary growth-patterned tumor. Tumor cells showed nuclear enlargement, irregularity, elongation, and overlapping as well as a few nuclear grooves. Nuclear pseudoinclusions were absent and chromatin characteristics were insufficient (nuclear score 2 according to Nikiforov et al. (1)). The patient was diagnosed with an encapsulated conventional papillary thyroid carcinoma by a local pathologist; however, a second-opinion consultation endorsed a follicular adenoma with papillary hyperplasia. In a third-opinion consultation, immunohistochemical analyses revealed a low MIB-1 labeling index and negative staining for cytokeratin 19 and BRAFV600E, which supported the expected indolent clinical behavior. Remarkably, mutational analysis identified a heterozygous point mutation of the KRAS gene but not the BRAF genes. Eventually, we speculated that this tumor could be a possible example of a novel borderline tumor with a papillary architecture, which does not qualify as NIFTP or UMP under the current WHO criteria. The patient refused additional surgery (complete thyroidectomy), and developed no recurrence or distant metastasis for 24 months. Conclusion: We reported a significant observer variation in a noninvasive encapsulated papillary growth-patterned tumor with delicate nuclear changes and a KRAS mutation. We speculated that our case could be an example of a novel borderline tumor with a papillary structure. Further studies using a larger number of patients are needed to elucidate this disease entity, because the possible introduction of terminology such as “noninvasive encapsulated papillary RAS-like thyroid tumor (NEPRAS)” without the word “cancer” could relieve psychological burdens of the patients similar to NIFTP. Reference: (1) Nikiforov YE, et al. Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors. JAMA Oncol. 2016;2:1023-9.

https://www.semanticscholar.org/paper/589d25a86b02d88a7502b48137f521b4905c3f51

Human Cornea Proteome: Identification and Quantitation of the Proteins of the Three Main Layers Including Epithelium, Stroma, and Endothelium

Journal of Proteome Research

c7bbca07-9604-48a6-85d8-512fa663722e

Human Cornea Proteome: Identification and Quantitation of the Proteins of the Three Main Layers Including Epithelium, Stroma, and Endothelium Diseases of the cornea are common and refer to conditions like infections, injuries and genetic defects. Morphologically, many corneal diseases affect only certain layers of the cornea and separate analysis of the individual layers is therefore of interest to explore the basic molecular mechanisms involved in corneal health and disease. In this study, the three main layers including, the epithelium, stroma and endothelium of healthy human corneas were isolated. Prior to analysis by LC–MS/MS the proteins from the different layers were either (i) separated by SDS-PAGE followed by in-gel trypsinization, (ii) in-solution digested without prior protein separation or, (iii) in-solution digested followed by cation exchange chromatography. A total of 3250 unique Swiss-Prot annotated proteins were identified in human corneas, 2737 in the epithelium, 1679 in the stroma, and 880 in the endothelial layer. Of these, 1787 proteins have not previously been identified in the human cornea by mass spectrometry. In total, 771 proteins were quantified, 157 based on in-solution digestion and 770 based on SDS-PAGE separation followed by in-gel digestion of excised gel pieces. Protein analysis showed that many of the identified proteins are plasma proteins involved in defense responses.

https://www.semanticscholar.org/paper/5f2633de7ba66b13a124c94a2b2b5ec374204552

Use of evidence for clinical practice guideline development

Tropical Parasitology

579e4def-20ca-4064-9a4c-c36000e86d18

Use of evidence for clinical practice guideline development Clinical practice guidelines provide a framework against which quality of care is measured. Recommendations contained within guidelines are used for decision-making not only within the clinical domain but also other related issues within the health systems. As such the use of research evidence for formulating recommendations contained in a guideline is a global standard to ensure guideline quality. The paper briefly reviews how the need for and use of evidence in guideline development shaped up historically and then provides an overview of the four typologies of guideline development mechanisms at the country level.

https://www.semanticscholar.org/paper/712b6f33158db2beb55ab71528c32080d3ae9d5b

Medical errors and consequent adverse events in critically ill surgical patients in a tertiary care teaching hospital in Delhi

Journal of Emergencies, Trauma and Shock

9506110b-8286-4511-bee3-c593f9419536

Medical errors and consequent adverse events in critically ill surgical patients in a tertiary care teaching hospital in Delhi Background: Medical errors and adverse events (AE), though common worldwide, have never been studied in India. We believe that though common these are under reported. Aim: The aim of this study was to study medical errors and consequent AE in patients presenting with trauma and bowel perforation peritonitis. Methods: Five hundred and eighty-six consecutive patients with trauma or peritonitis, presenting to surgery emergency of UCMS-GTBH, were prospectively studied using review form (RF) 1 and 2. AE was defined as an outcome not expected to be part of the illness. RF 1 was filled for all and indicated if AE was present or not. RF2 was filled when RF 1 indicated presence of AE; it further confirmed the occurrence of AE and pointed to the type of medical error and resultant disability. All results were expressed as percentage. Results: There were 500 (85%) males. Mean age of the patients was 31 years. There were 332 patients with peritonitis and 254 with trauma. AE and its consequences were present in 185 (31.5%) and 183 (31.2%) patients, respectively. Consequences were as follows: disability – 157 (85%), increased hospital stay and/or increased visits in the OPD – 28 (15.3%) and both-101 (55.2%) patients. Disabilities were: death – 62 (40%), temporary disability – 90 (58%) and permanent disability – 05 (3.1%) patients. AE in 133 (71.8%) patients was definitely (level of confidence 6) due to error in healthcare management. All AE were considered preventable. Error of omission accounted for AE in 122 (65.9%) patients. System and operative errors were the commonest, 84.3% and 82.7%, respectively. One hundred and sixty-seven (90%) patients had multiple errors. Conclusions: The study proves that medical errors and AE are a serious problem in our set-up and calls for immediate system improvement.

https://www.semanticscholar.org/paper/91a519d794cfd415749942723a7638cdb142707e

catena-Poly[[bis(μ2-4-aminobenzenesulfonato-κ2 O:O)disilver]-bis(μ2-4,4′-bipyridine-κ2 N:N′)]

Acta Crystallographica Section E

3764f162-def2-425e-a8d5-f015eb75ff7a

catena-Poly-bis(μ2-4,4′-bipyridine-κ2 N:N′)] In the title compound, n, the AgI atom is four-coordinated by two N atoms from two symmetry-related 4,4′-bipyridine (bipy) and two O atoms from two independent 4-aminobenzenesulfonate (ABS) ligands. The two inter-chain AgI atoms are bridged by two independent ABS ligands through weak Ag—O bonds and Ag⋯Ag attractions, forming a ladder-like chain coordination polymer n parallel to , which is further linked to generate a two-dimensional structure via N—H⋯O hydrogen-bonding interactions.

https://www.semanticscholar.org/paper/b4577ae0389ca1a568fcfa440980cb551e786f2c

Modified port placement and pedicle first approach for laparoscopic concomitant cholecystectomy and splenectomy in children

Journal of Indian Association of Pediatric Surgeons

b68cbbfd-7c8f-41de-8509-f91781aef19b

Modified port placement and pedicle first approach for laparoscopic concomitant cholecystectomy and splenectomy in children Aim: Laparoscopy is becoming the preferred modality for concomitant cholecystectomy and splenectomy (CAS). Usually, six to seven ports are employed for CAS, and spleen is removed by classical lateral approach or anterior approach. We report here our modified five-port and pedicle first approach for CAS in children to minimize the intraoperative bleeding and maximize the access. Materials and Methods: Twenty-one children underwent laparoscopic CAS with this new approach and their data were recorded prospectively. Following cholecystectomy (with ports 1–4), left side was elevated by 30°. The spleen was lifted by a grasper/fan retractor through port no. 5. The pedicle was dissected and splenic vessels were divided by ligasure (vessels < 8 mm), and for bulkier pedicle, vascular endo-GIA stapler was used. Short gastric and gastrosplenic ligament, lower pole and phrenico-colic attachments and upper pole attachments were dissected by ligasure in that sequence. Spleen was placed in endosac and delivered by digital fracture technique. Occasionally, lower transverse incision was made to deliver a massive spleen. Results: There were 12 males and 9 females with an average age of 8 years. Fourteen had sickle cell disease (SCD) and 7 had SCD and beta thalassemia. All CAS were completed successfully without any complication. Total duration was 160 minutes. Cholecystectomy took an average of 35 minutes. Average blood loss was 140 ml. The mean splenic weight was 900 g and mean length was 20 cm. Duration of hospitalization was 3–4 days. Conclusion: CAS can be successfully performed by five ports. The pedicle first approach is extremely helpful in moderate to massive spleens as it reduces splenic size, vascularity and bleeding from capsular adhesions or inadvertant lacerations.

https://www.semanticscholar.org/paper/ffd1921933eec6a450c0dc8792c59f2e2ccfeaac

"The Hospital" Nursing Mirror

The Hospital

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"The Hospital" Nursing Mirror THE QUEEN'S GIFT TO A DUBLIN HOSPITAL. The Children's Hospital, Temple Street, Dublin, was specially favoured by Royalty on tlie day of the Queen's departure. Miss Minnie Cochrane drove up to the hospital in the morning, conveying a gift from the Queen as a memento of the joining of the " Moy-Mell" Children's Guild by the little Battenberg Princess and Princes. The present consisted of a very handsome, large, framed engraving, named " The Queen with her Grandchildren and Favourites at Osborne," and representing the Queen driving in her pony-chair across a grassy lawn, surrounded by the children of Princess Henry of Battenberg. Seven pet dogs also appear in the picture. The Guild, which has been joined by the young Princess and Princes, has for its object the interesting of happy and well-nurtured children in the less fortunate little ones of the poor. The good Sisters of Charity, who form the governing body of the hospital, are often hampered in their work by a lack of