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Transplantation is an umlsterm, Amnionmembran is an umlsterm, Patienten is an umlsterm
DerOpthalmologe.00970100.ger.abstr_task0
Sentence: Fragestellung : Stellenwert der Transplantation von Amnionmembran ( AMT ) zur Rekonstruktion des perilimbalen Stromas bei Patienten mit Limbusinsuffizienz ( LI ) . Desweiteren wurde die Erfolgsrate der AMT mit oder ohne allogener Limbustransplantation ( aLT ) bei LI analysiert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Fragestellung : Stellenwert der Transplantation von Amnionmembran ( AMT ) zur Rekonstruktion des perilimbalen Stromas bei Patienten mit Limbusinsuffizienz ( LI ) . Desweiteren wurde die Erfolgsrate der AMT mit oder ohne allogener Limbustransplantation ( aLT ) bei LI analysiert .
[ "Fragestellung", ":", "Stellenwert", "der", "Transplantation", "von", "Amnionmembran", "(", "AMT", ")", "zur", "Rekonstruktion", "des", "perilimbalen", "Stromas", "bei", "Patienten", "mit", "Limbusinsuffizienz", "(", "LI", ")", ".", "Desweiteren", "wurde", "die", "Erfolgsrate", "der", "AMT", "mit", "oder", "ohne", "allogener", "Limbustransplantation", "(", "aLT", ")", "bei", "LI", "analysiert", "." ]
[ "umlsterm" ]
Transplantation is an umlsterm, Amnionmembran is an umlsterm, Patienten is an umlsterm
DerOpthalmologe.00970100.ger.abstr_task1
Sentence: Fragestellung : Stellenwert der Transplantation von Amnionmembran ( AMT ) zur Rekonstruktion des perilimbalen Stromas bei Patienten mit Limbusinsuffizienz ( LI ) . Desweiteren wurde die Erfolgsrate der AMT mit oder ohne allogener Limbustransplantation ( aLT ) bei LI analysiert . Instructions: please typing these entity words according to sentence: Transplantation, Amnionmembran, Patienten Options: umlsterm
[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Fragestellung : Stellenwert der Transplantation von Amnionmembran ( AMT ) zur Rekonstruktion des perilimbalen Stromas bei Patienten mit Limbusinsuffizienz ( LI ) . Desweiteren wurde die Erfolgsrate der AMT mit oder ohne allogener Limbustransplantation ( aLT ) bei LI analysiert .
[ "Fragestellung", ":", "Stellenwert", "der", "Transplantation", "von", "Amnionmembran", "(", "AMT", ")", "zur", "Rekonstruktion", "des", "perilimbalen", "Stromas", "bei", "Patienten", "mit", "Limbusinsuffizienz", "(", "LI", ")", ".", "Desweiteren", "wurde", "die", "Erfolgsrate", "der", "AMT", "mit", "oder", "ohne", "allogener", "Limbustransplantation", "(", "aLT", ")", "bei", "LI", "analysiert", "." ]
[ "umlsterm" ]
Transplantation, Amnionmembran, Patienten
DerOpthalmologe.00970100.ger.abstr_task2
Sentence: Fragestellung : Stellenwert der Transplantation von Amnionmembran ( AMT ) zur Rekonstruktion des perilimbalen Stromas bei Patienten mit Limbusinsuffizienz ( LI ) . Desweiteren wurde die Erfolgsrate der AMT mit oder ohne allogener Limbustransplantation ( aLT ) bei LI analysiert . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Fragestellung : Stellenwert der Transplantation von Amnionmembran ( AMT ) zur Rekonstruktion des perilimbalen Stromas bei Patienten mit Limbusinsuffizienz ( LI ) . Desweiteren wurde die Erfolgsrate der AMT mit oder ohne allogener Limbustransplantation ( aLT ) bei LI analysiert .
[ "Fragestellung", ":", "Stellenwert", "der", "Transplantation", "von", "Amnionmembran", "(", "AMT", ")", "zur", "Rekonstruktion", "des", "perilimbalen", "Stromas", "bei", "Patienten", "mit", "Limbusinsuffizienz", "(", "LI", ")", ".", "Desweiteren", "wurde", "die", "Erfolgsrate", "der", "AMT", "mit", "oder", "ohne", "allogener", "Limbustransplantation", "(", "aLT", ")", "bei", "LI", "analysiert", "." ]
[ "umlsterm" ]
Schmerzfreiheit is an umlsterm, Wiederherstellung is an umlsterm, Schultergelenkfunktion is an umlsterm
OperativeOrthopaedie.90110255.ger.abstr_task0
Sentence: Operationsziel Schmerzfreiheit und Wiederherstellung der Schultergelenkfunktion . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]
Operationsziel Schmerzfreiheit und Wiederherstellung der Schultergelenkfunktion .
[ "Operationsziel", "Schmerzfreiheit", "und", "Wiederherstellung", "der", "Schultergelenkfunktion", "." ]
[ "umlsterm" ]
Schmerzfreiheit is an umlsterm, Wiederherstellung is an umlsterm, Schultergelenkfunktion is an umlsterm
OperativeOrthopaedie.90110255.ger.abstr_task1
Sentence: Operationsziel Schmerzfreiheit und Wiederherstellung der Schultergelenkfunktion . Instructions: please typing these entity words according to sentence: Schmerzfreiheit, Wiederherstellung, Schultergelenkfunktion Options: umlsterm
[ "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]
Operationsziel Schmerzfreiheit und Wiederherstellung der Schultergelenkfunktion .
[ "Operationsziel", "Schmerzfreiheit", "und", "Wiederherstellung", "der", "Schultergelenkfunktion", "." ]
[ "umlsterm" ]
Schmerzfreiheit, Wiederherstellung, Schultergelenkfunktion
OperativeOrthopaedie.90110255.ger.abstr_task2
Sentence: Operationsziel Schmerzfreiheit und Wiederherstellung der Schultergelenkfunktion . Instructions: please extract entity words from the input sentence
[ "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]
Operationsziel Schmerzfreiheit und Wiederherstellung der Schultergelenkfunktion .
[ "Operationsziel", "Schmerzfreiheit", "und", "Wiederherstellung", "der", "Schultergelenkfunktion", "." ]
[ "umlsterm" ]
UL5 is a Gene/protein/RNA, UL8 is a Gene/protein/RNA, major DNA - binding protein is a Gene/protein/RNA, DNA polymerase is a Gene/protein/RNA, UL42 is a Gene/protein/RNA, UL52 is a Gene/protein/RNA
833_task0
Sentence: To characterize the AAV functions mediating this effect, cloned AAV type 2 wild-type or mutant genomes were transfected into simian virus 40 (SV40)-transformed hamster cells together with the six HSV replication genes (encoding UL5, UL8, major DNA-binding protein, DNA polymerase, UL42, and UL52) which together are necessary and sufficient for the induction of SV40 DNA amplification (R. Heilbronn and H. zur Hausen, J. Virol. 63:3683-3692, 1989). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene/protein/RNA
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
To characterize the AAV functions mediating this effect, cloned AAV type 2 wild-type or mutant genomes were transfected into simian virus 40 (SV40)-transformed hamster cells together with the six HSV replication genes (encoding UL5, UL8, major DNA-binding protein, DNA polymerase, UL42, and UL52) which together are necessary and sufficient for the induction of SV40 DNA amplification (R. Heilbronn and H. zur Hausen, J. Virol. 63:3683-3692, 1989).
[ "To", "characterize", "the", "AAV", "functions", "mediating", "this", "effect", ",", "cloned", "AAV", "type", "2", "wild", "-", "type", "or", "mutant", "genomes", "were", "transfected", "into", "simian", "virus", "40", "(", "SV40)-transformed", "hamster", "cells", "together", "with", "the", "six", "HSV", "replication", "genes", "(", "encoding", "UL5", ",", "UL8", ",", "major", "DNA", "-", "binding", "protein", ",", "DNA", "polymerase", ",", "UL42", ",", "and", "UL52", ")", "which", "together", "are", "necessary", "and", "sufficient", "for", "the", "induction", "of", "SV40", "DNA", "amplification", "(", "R.", "Heilbronn", "and", "H.", "zur", "Hausen", ",", "J.", "Virol", ".", "63:3683", "-", "3692", ",", "1989", ")", "." ]
[ "Gene/protein/RNA" ]
UL5 is a Gene/protein/RNA, UL8 is a Gene/protein/RNA, major DNA - binding protein is a Gene/protein/RNA, DNA polymerase is a Gene/protein/RNA, UL42 is a Gene/protein/RNA, UL52 is a Gene/protein/RNA
833_task1
Sentence: To characterize the AAV functions mediating this effect, cloned AAV type 2 wild-type or mutant genomes were transfected into simian virus 40 (SV40)-transformed hamster cells together with the six HSV replication genes (encoding UL5, UL8, major DNA-binding protein, DNA polymerase, UL42, and UL52) which together are necessary and sufficient for the induction of SV40 DNA amplification (R. Heilbronn and H. zur Hausen, J. Virol. 63:3683-3692, 1989). Instructions: please typing these entity words according to sentence: UL5, UL8, major DNA - binding protein, DNA polymerase, UL42, UL52 Options: Gene/protein/RNA
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
To characterize the AAV functions mediating this effect, cloned AAV type 2 wild-type or mutant genomes were transfected into simian virus 40 (SV40)-transformed hamster cells together with the six HSV replication genes (encoding UL5, UL8, major DNA-binding protein, DNA polymerase, UL42, and UL52) which together are necessary and sufficient for the induction of SV40 DNA amplification (R. Heilbronn and H. zur Hausen, J. Virol. 63:3683-3692, 1989).
[ "To", "characterize", "the", "AAV", "functions", "mediating", "this", "effect", ",", "cloned", "AAV", "type", "2", "wild", "-", "type", "or", "mutant", "genomes", "were", "transfected", "into", "simian", "virus", "40", "(", "SV40)-transformed", "hamster", "cells", "together", "with", "the", "six", "HSV", "replication", "genes", "(", "encoding", "UL5", ",", "UL8", ",", "major", "DNA", "-", "binding", "protein", ",", "DNA", "polymerase", ",", "UL42", ",", "and", "UL52", ")", "which", "together", "are", "necessary", "and", "sufficient", "for", "the", "induction", "of", "SV40", "DNA", "amplification", "(", "R.", "Heilbronn", "and", "H.", "zur", "Hausen", ",", "J.", "Virol", ".", "63:3683", "-", "3692", ",", "1989", ")", "." ]
[ "Gene/protein/RNA" ]
UL5, UL8, major DNA - binding protein, DNA polymerase, UL42, UL52
833_task2
Sentence: To characterize the AAV functions mediating this effect, cloned AAV type 2 wild-type or mutant genomes were transfected into simian virus 40 (SV40)-transformed hamster cells together with the six HSV replication genes (encoding UL5, UL8, major DNA-binding protein, DNA polymerase, UL42, and UL52) which together are necessary and sufficient for the induction of SV40 DNA amplification (R. Heilbronn and H. zur Hausen, J. Virol. 63:3683-3692, 1989). Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
To characterize the AAV functions mediating this effect, cloned AAV type 2 wild-type or mutant genomes were transfected into simian virus 40 (SV40)-transformed hamster cells together with the six HSV replication genes (encoding UL5, UL8, major DNA-binding protein, DNA polymerase, UL42, and UL52) which together are necessary and sufficient for the induction of SV40 DNA amplification (R. Heilbronn and H. zur Hausen, J. Virol. 63:3683-3692, 1989).
[ "To", "characterize", "the", "AAV", "functions", "mediating", "this", "effect", ",", "cloned", "AAV", "type", "2", "wild", "-", "type", "or", "mutant", "genomes", "were", "transfected", "into", "simian", "virus", "40", "(", "SV40)-transformed", "hamster", "cells", "together", "with", "the", "six", "HSV", "replication", "genes", "(", "encoding", "UL5", ",", "UL8", ",", "major", "DNA", "-", "binding", "protein", ",", "DNA", "polymerase", ",", "UL42", ",", "and", "UL52", ")", "which", "together", "are", "necessary", "and", "sufficient", "for", "the", "induction", "of", "SV40", "DNA", "amplification", "(", "R.", "Heilbronn", "and", "H.", "zur", "Hausen", ",", "J.", "Virol", ".", "63:3683", "-", "3692", ",", "1989", ")", "." ]
[ "Gene/protein/RNA" ]
UL5 is a Gene/protein/RNA, UL8 is a Gene/protein/RNA, UL9 is a Gene/protein/RNA, UL52 is a Gene/protein/RNA
842_task0
Sentence: To improve our ability to study these proteins, we have expressed UL5, UL8, UL9, and UL52 in insect cells by using the baculovirus expression system. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene/protein/RNA
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
To improve our ability to study these proteins, we have expressed UL5, UL8, UL9, and UL52 in insect cells by using the baculovirus expression system.
[ "To", "improve", "our", "ability", "to", "study", "these", "proteins", ",", "we", "have", "expressed", "UL5", ",", "UL8", ",", "UL9", ",", "and", "UL52", "in", "insect", "cells", "by", "using", "the", "baculovirus", "expression", "system", "." ]
[ "Gene/protein/RNA" ]
UL5 is a Gene/protein/RNA, UL8 is a Gene/protein/RNA, UL9 is a Gene/protein/RNA, UL52 is a Gene/protein/RNA
842_task1
Sentence: To improve our ability to study these proteins, we have expressed UL5, UL8, UL9, and UL52 in insect cells by using the baculovirus expression system. Instructions: please typing these entity words according to sentence: UL5, UL8, UL9, UL52 Options: Gene/protein/RNA
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
To improve our ability to study these proteins, we have expressed UL5, UL8, UL9, and UL52 in insect cells by using the baculovirus expression system.
[ "To", "improve", "our", "ability", "to", "study", "these", "proteins", ",", "we", "have", "expressed", "UL5", ",", "UL8", ",", "UL9", ",", "and", "UL52", "in", "insect", "cells", "by", "using", "the", "baculovirus", "expression", "system", "." ]
[ "Gene/protein/RNA" ]
UL5, UL8, UL9, UL52
842_task2
Sentence: To improve our ability to study these proteins, we have expressed UL5, UL8, UL9, and UL52 in insect cells by using the baculovirus expression system. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
To improve our ability to study these proteins, we have expressed UL5, UL8, UL9, and UL52 in insect cells by using the baculovirus expression system.
[ "To", "improve", "our", "ability", "to", "study", "these", "proteins", ",", "we", "have", "expressed", "UL5", ",", "UL8", ",", "UL9", ",", "and", "UL52", "in", "insect", "cells", "by", "using", "the", "baculovirus", "expression", "system", "." ]
[ "Gene/protein/RNA" ]
Outpatient is an umlsterm, rehabilitation is an umlsterm, inpatient is an umlsterm, rehabilitation is an umlsterm, patient is an umlsterm, secondary is an umlsterm, prevention is an umlsterm, quality of life is an umlsterm, patients is an umlsterm, heart disease is an umlsterm, outpatients is an umlsterm, life is an umlsterm, heart diseases is an umlsterm, elderly is an umlsterm, patients is an umlsterm, disease is an umlsterm, life style is an umlsterm, chronic disease is an umlsterm, chronically ill is an umlsterm, inpatient is an umlsterm, all is an umlsterm, patient is an umlsterm
ZfuerKardiologie.8087s225.eng.abstr_task0
Sentence: Outpatient cardiac rehabilitation , as compared to inpatient rehabilitation , has substantial disadvantages for several patient groups . These drawbacks may lead to insufficient results in long term secondary prevention and to inadequate quality of life in patients with chronic heart disease . As outpatients , they remain in life circumstances which were , at least in part , causative for their heart diseases . Especially in elderly patients , those with a complicated course of disease , those who find adjusting their life style to the chronic disease state a daunting task , and those who find coping with the fact of being chronically ill as surpassing their psychological skills will find only in an inpatient setting all the relevant support delivered by a team of experts complementing each other for the benefit of the patient . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]
Outpatient cardiac rehabilitation , as compared to inpatient rehabilitation , has substantial disadvantages for several patient groups . These drawbacks may lead to insufficient results in long term secondary prevention and to inadequate quality of life in patients with chronic heart disease . As outpatients , they remain in life circumstances which were , at least in part , causative for their heart diseases . Especially in elderly patients , those with a complicated course of disease , those who find adjusting their life style to the chronic disease state a daunting task , and those who find coping with the fact of being chronically ill as surpassing their psychological skills will find only in an inpatient setting all the relevant support delivered by a team of experts complementing each other for the benefit of the patient .
[ "Outpatient", "cardiac", "rehabilitation", ",", "as", "compared", "to", "inpatient", "rehabilitation", ",", "has", "substantial", "disadvantages", "for", "several", "patient", "groups", ".", "These", "drawbacks", "may", "lead", "to", "insufficient", "results", "in", "long", "term", "secondary", "prevention", "and", "to", "inadequate", "quality", "of", "life", "in", "patients", "with", "chronic", "heart", "disease", ".", "As", "outpatients", ",", "they", "remain", "in", "life", "circumstances", "which", "were", ",", "at", "least", "in", "part", ",", "causative", "for", "their", "heart", "diseases", ".", "Especially", "in", "elderly", "patients", ",", "those", "with", "a", "complicated", "course", "of", "disease", ",", "those", "who", "find", "adjusting", "their", "life", "style", "to", "the", "chronic", "disease", "state", "a", "daunting", "task", ",", "and", "those", "who", "find", "coping", "with", "the", "fact", "of", "being", "chronically", "ill", "as", "surpassing", "their", "psychological", "skills", "will", "find", "only", "in", "an", "inpatient", "setting", "all", "the", "relevant", "support", "delivered", "by", "a", "team", "of", "experts", "complementing", "each", "other", "for", "the", "benefit", "of", "the", "patient", "." ]
[ "umlsterm" ]
Outpatient is an umlsterm, rehabilitation is an umlsterm, inpatient is an umlsterm, rehabilitation is an umlsterm, patient is an umlsterm, secondary is an umlsterm, prevention is an umlsterm, quality of life is an umlsterm, patients is an umlsterm, heart disease is an umlsterm, outpatients is an umlsterm, life is an umlsterm, heart diseases is an umlsterm, elderly is an umlsterm, patients is an umlsterm, disease is an umlsterm, life style is an umlsterm, chronic disease is an umlsterm, chronically ill is an umlsterm, inpatient is an umlsterm, all is an umlsterm, patient is an umlsterm
ZfuerKardiologie.8087s225.eng.abstr_task1
Sentence: Outpatient cardiac rehabilitation , as compared to inpatient rehabilitation , has substantial disadvantages for several patient groups . These drawbacks may lead to insufficient results in long term secondary prevention and to inadequate quality of life in patients with chronic heart disease . As outpatients , they remain in life circumstances which were , at least in part , causative for their heart diseases . Especially in elderly patients , those with a complicated course of disease , those who find adjusting their life style to the chronic disease state a daunting task , and those who find coping with the fact of being chronically ill as surpassing their psychological skills will find only in an inpatient setting all the relevant support delivered by a team of experts complementing each other for the benefit of the patient . Instructions: please typing these entity words according to sentence: Outpatient, rehabilitation, inpatient, rehabilitation, patient, secondary, prevention, quality of life, patients, heart disease, outpatients, life, heart diseases, elderly, patients, disease, life style, chronic disease, chronically ill, inpatient, all, patient Options: umlsterm
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Outpatient cardiac rehabilitation , as compared to inpatient rehabilitation , has substantial disadvantages for several patient groups . These drawbacks may lead to insufficient results in long term secondary prevention and to inadequate quality of life in patients with chronic heart disease . As outpatients , they remain in life circumstances which were , at least in part , causative for their heart diseases . Especially in elderly patients , those with a complicated course of disease , those who find adjusting their life style to the chronic disease state a daunting task , and those who find coping with the fact of being chronically ill as surpassing their psychological skills will find only in an inpatient setting all the relevant support delivered by a team of experts complementing each other for the benefit of the patient .
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[ "umlsterm" ]
Outpatient, rehabilitation, inpatient, rehabilitation, patient, secondary, prevention, quality of life, patients, heart disease, outpatients, life, heart diseases, elderly, patients, disease, life style, chronic disease, chronically ill, inpatient, all, patient
ZfuerKardiologie.8087s225.eng.abstr_task2
Sentence: Outpatient cardiac rehabilitation , as compared to inpatient rehabilitation , has substantial disadvantages for several patient groups . These drawbacks may lead to insufficient results in long term secondary prevention and to inadequate quality of life in patients with chronic heart disease . As outpatients , they remain in life circumstances which were , at least in part , causative for their heart diseases . Especially in elderly patients , those with a complicated course of disease , those who find adjusting their life style to the chronic disease state a daunting task , and those who find coping with the fact of being chronically ill as surpassing their psychological skills will find only in an inpatient setting all the relevant support delivered by a team of experts complementing each other for the benefit of the patient . Instructions: please extract entity words from the input sentence
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Outpatient cardiac rehabilitation , as compared to inpatient rehabilitation , has substantial disadvantages for several patient groups . These drawbacks may lead to insufficient results in long term secondary prevention and to inadequate quality of life in patients with chronic heart disease . As outpatients , they remain in life circumstances which were , at least in part , causative for their heart diseases . Especially in elderly patients , those with a complicated course of disease , those who find adjusting their life style to the chronic disease state a daunting task , and those who find coping with the fact of being chronically ill as surpassing their psychological skills will find only in an inpatient setting all the relevant support delivered by a team of experts complementing each other for the benefit of the patient .
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[ "umlsterm" ]
Beobachtung is an umlsterm, Pathophysiologie is an umlsterm, Patienten is an umlsterm, Hypaesthesien is an umlsterm, Patienten is an umlsterm, therapie - resistente is an umlsterm, Aetiologien is an umlsterm, Hypaesthesien is an umlsterm, Patienten is an umlsterm, Therapie is an umlsterm, Anaesthesien is an umlsterm, Koerperwahrnehmung is an umlsterm, Beobachtungen is an umlsterm, Beobachtung is an umlsterm
ManuelleMedizin.70350063.ger.abstr_task0
Sentence: Hinweis auf die Beobachtung einer Pathophysiologie im Bereich der peripheren , sensiblen , nozizeptiven Afferenz , die im Klientel WS-verunfallter Patienten auffiel . In der Folge von Traumatisierungen der WS fanden sich segmentale , pluri-segmentale bis halbseitige Hypaesthesien bei Patienten , bei denen eine therapie-resistente , leidensintensive Symptomatik bestand . Klassische neurologische Aetiologien fuer diese Hypaesthesien lagen nicht vor . Die Patienten reagierten auf normale " Therapie " mit Beschwerdeverstaerkung . Je nach Ausbreitung der Hypo- bis Anaesthesien wurde das klinische Bild auch von Stoerungen im efferenten Bereich ( Koordinationsstoerungen Stoerungen , in der Koerperwahrnehmung u. ae . ) begleitet . Kollegen , die aehnliche Beobachtungen gemacht haben , bzw. mit dieser Symptomatik vertraut sind , werden gebeten bei der Interpretation dieser Beobachtung behilflich zu sein . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Hinweis auf die Beobachtung einer Pathophysiologie im Bereich der peripheren , sensiblen , nozizeptiven Afferenz , die im Klientel WS-verunfallter Patienten auffiel . In der Folge von Traumatisierungen der WS fanden sich segmentale , pluri-segmentale bis halbseitige Hypaesthesien bei Patienten , bei denen eine therapie-resistente , leidensintensive Symptomatik bestand . Klassische neurologische Aetiologien fuer diese Hypaesthesien lagen nicht vor . Die Patienten reagierten auf normale " Therapie " mit Beschwerdeverstaerkung . Je nach Ausbreitung der Hypo- bis Anaesthesien wurde das klinische Bild auch von Stoerungen im efferenten Bereich ( Koordinationsstoerungen Stoerungen , in der Koerperwahrnehmung u. ae . ) begleitet . Kollegen , die aehnliche Beobachtungen gemacht haben , bzw. mit dieser Symptomatik vertraut sind , werden gebeten bei der Interpretation dieser Beobachtung behilflich zu sein .
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[ "umlsterm" ]
Beobachtung is an umlsterm, Pathophysiologie is an umlsterm, Patienten is an umlsterm, Hypaesthesien is an umlsterm, Patienten is an umlsterm, therapie - resistente is an umlsterm, Aetiologien is an umlsterm, Hypaesthesien is an umlsterm, Patienten is an umlsterm, Therapie is an umlsterm, Anaesthesien is an umlsterm, Koerperwahrnehmung is an umlsterm, Beobachtungen is an umlsterm, Beobachtung is an umlsterm
ManuelleMedizin.70350063.ger.abstr_task1
Sentence: Hinweis auf die Beobachtung einer Pathophysiologie im Bereich der peripheren , sensiblen , nozizeptiven Afferenz , die im Klientel WS-verunfallter Patienten auffiel . In der Folge von Traumatisierungen der WS fanden sich segmentale , pluri-segmentale bis halbseitige Hypaesthesien bei Patienten , bei denen eine therapie-resistente , leidensintensive Symptomatik bestand . Klassische neurologische Aetiologien fuer diese Hypaesthesien lagen nicht vor . Die Patienten reagierten auf normale " Therapie " mit Beschwerdeverstaerkung . Je nach Ausbreitung der Hypo- bis Anaesthesien wurde das klinische Bild auch von Stoerungen im efferenten Bereich ( Koordinationsstoerungen Stoerungen , in der Koerperwahrnehmung u. ae . ) begleitet . Kollegen , die aehnliche Beobachtungen gemacht haben , bzw. mit dieser Symptomatik vertraut sind , werden gebeten bei der Interpretation dieser Beobachtung behilflich zu sein . Instructions: please typing these entity words according to sentence: Beobachtung, Pathophysiologie, Patienten, Hypaesthesien, Patienten, therapie - resistente, Aetiologien, Hypaesthesien, Patienten, Therapie, Anaesthesien, Koerperwahrnehmung, Beobachtungen, Beobachtung Options: umlsterm
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Hinweis auf die Beobachtung einer Pathophysiologie im Bereich der peripheren , sensiblen , nozizeptiven Afferenz , die im Klientel WS-verunfallter Patienten auffiel . In der Folge von Traumatisierungen der WS fanden sich segmentale , pluri-segmentale bis halbseitige Hypaesthesien bei Patienten , bei denen eine therapie-resistente , leidensintensive Symptomatik bestand . Klassische neurologische Aetiologien fuer diese Hypaesthesien lagen nicht vor . Die Patienten reagierten auf normale " Therapie " mit Beschwerdeverstaerkung . Je nach Ausbreitung der Hypo- bis Anaesthesien wurde das klinische Bild auch von Stoerungen im efferenten Bereich ( Koordinationsstoerungen Stoerungen , in der Koerperwahrnehmung u. ae . ) begleitet . Kollegen , die aehnliche Beobachtungen gemacht haben , bzw. mit dieser Symptomatik vertraut sind , werden gebeten bei der Interpretation dieser Beobachtung behilflich zu sein .
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[ "umlsterm" ]
Beobachtung, Pathophysiologie, Patienten, Hypaesthesien, Patienten, therapie - resistente, Aetiologien, Hypaesthesien, Patienten, Therapie, Anaesthesien, Koerperwahrnehmung, Beobachtungen, Beobachtung
ManuelleMedizin.70350063.ger.abstr_task2
Sentence: Hinweis auf die Beobachtung einer Pathophysiologie im Bereich der peripheren , sensiblen , nozizeptiven Afferenz , die im Klientel WS-verunfallter Patienten auffiel . In der Folge von Traumatisierungen der WS fanden sich segmentale , pluri-segmentale bis halbseitige Hypaesthesien bei Patienten , bei denen eine therapie-resistente , leidensintensive Symptomatik bestand . Klassische neurologische Aetiologien fuer diese Hypaesthesien lagen nicht vor . Die Patienten reagierten auf normale " Therapie " mit Beschwerdeverstaerkung . Je nach Ausbreitung der Hypo- bis Anaesthesien wurde das klinische Bild auch von Stoerungen im efferenten Bereich ( Koordinationsstoerungen Stoerungen , in der Koerperwahrnehmung u. ae . ) begleitet . Kollegen , die aehnliche Beobachtungen gemacht haben , bzw. mit dieser Symptomatik vertraut sind , werden gebeten bei der Interpretation dieser Beobachtung behilflich zu sein . Instructions: please extract entity words from the input sentence
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Hinweis auf die Beobachtung einer Pathophysiologie im Bereich der peripheren , sensiblen , nozizeptiven Afferenz , die im Klientel WS-verunfallter Patienten auffiel . In der Folge von Traumatisierungen der WS fanden sich segmentale , pluri-segmentale bis halbseitige Hypaesthesien bei Patienten , bei denen eine therapie-resistente , leidensintensive Symptomatik bestand . Klassische neurologische Aetiologien fuer diese Hypaesthesien lagen nicht vor . Die Patienten reagierten auf normale " Therapie " mit Beschwerdeverstaerkung . Je nach Ausbreitung der Hypo- bis Anaesthesien wurde das klinische Bild auch von Stoerungen im efferenten Bereich ( Koordinationsstoerungen Stoerungen , in der Koerperwahrnehmung u. ae . ) begleitet . Kollegen , die aehnliche Beobachtungen gemacht haben , bzw. mit dieser Symptomatik vertraut sind , werden gebeten bei der Interpretation dieser Beobachtung behilflich zu sein .
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[ "umlsterm" ]
Augenlidern is an umlsterm, Oedem is an umlsterm, Patienten is an umlsterm, Schmerzen is an umlsterm, Juckreiz is an umlsterm, Inzidenz is an umlsterm
DerHautarzt.60470002.ger.abstr_task0
Sentence: An den Augenlidern manifestieren sich unterschiedlichste Erkrankungen . Ein haeufiges Symptom dieser Region ist die Schwellung , der wiederum oft ein Oedem zugrundeliegt . Neben einer Beschreibung der pathophysiologischen und anatomischen Grundlagen soll im vorliegenden Text vor allem eine praktische Anleitung - unter anderem mit Flussdiagrammen - zum differentialdiagnostischen Vorgehen bei Patienten mit Lidschwellung gegeben werden . Hierbei erweist sich die subjektive Symptomatik ( Schmerzen , Juckreiz ) als sinnvolles Orientierungskriterium . Die Erkrankungen werden , nach Inzidenz gereiht , in tabellarischer Form charakterisiert . Besonderes Augenmerk gilt den allergischen Ursachen fuer Lidschwellungen sowie dem Zusammenhang zwischen Lidschwellung und atrophischen Lidveraenderungen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
An den Augenlidern manifestieren sich unterschiedlichste Erkrankungen . Ein haeufiges Symptom dieser Region ist die Schwellung , der wiederum oft ein Oedem zugrundeliegt . Neben einer Beschreibung der pathophysiologischen und anatomischen Grundlagen soll im vorliegenden Text vor allem eine praktische Anleitung - unter anderem mit Flussdiagrammen - zum differentialdiagnostischen Vorgehen bei Patienten mit Lidschwellung gegeben werden . Hierbei erweist sich die subjektive Symptomatik ( Schmerzen , Juckreiz ) als sinnvolles Orientierungskriterium . Die Erkrankungen werden , nach Inzidenz gereiht , in tabellarischer Form charakterisiert . Besonderes Augenmerk gilt den allergischen Ursachen fuer Lidschwellungen sowie dem Zusammenhang zwischen Lidschwellung und atrophischen Lidveraenderungen .
[ "An", "den", "Augenlidern", "manifestieren", "sich", "unterschiedlichste", "Erkrankungen", ".", "Ein", "haeufiges", "Symptom", "dieser", "Region", "ist", "die", "Schwellung", ",", "der", "wiederum", "oft", "ein", "Oedem", "zugrundeliegt", ".", "Neben", "einer", "Beschreibung", "der", "pathophysiologischen", "und", "anatomischen", "Grundlagen", "soll", "im", "vorliegenden", "Text", "vor", "allem", "eine", "praktische", "Anleitung", "-", "unter", "anderem", "mit", "Flussdiagrammen", "-", "zum", "differentialdiagnostischen", "Vorgehen", "bei", "Patienten", "mit", "Lidschwellung", "gegeben", "werden", ".", "Hierbei", "erweist", "sich", "die", "subjektive", "Symptomatik", "(", "Schmerzen", ",", "Juckreiz", ")", "als", "sinnvolles", "Orientierungskriterium", ".", "Die", "Erkrankungen", "werden", ",", "nach", "Inzidenz", "gereiht", ",", "in", "tabellarischer", "Form", "charakterisiert", ".", "Besonderes", "Augenmerk", "gilt", "den", "allergischen", "Ursachen", "fuer", "Lidschwellungen", "sowie", "dem", "Zusammenhang", "zwischen", "Lidschwellung", "und", "atrophischen", "Lidveraenderungen", "." ]
[ "umlsterm" ]
Augenlidern is an umlsterm, Oedem is an umlsterm, Patienten is an umlsterm, Schmerzen is an umlsterm, Juckreiz is an umlsterm, Inzidenz is an umlsterm
DerHautarzt.60470002.ger.abstr_task1
Sentence: An den Augenlidern manifestieren sich unterschiedlichste Erkrankungen . Ein haeufiges Symptom dieser Region ist die Schwellung , der wiederum oft ein Oedem zugrundeliegt . Neben einer Beschreibung der pathophysiologischen und anatomischen Grundlagen soll im vorliegenden Text vor allem eine praktische Anleitung - unter anderem mit Flussdiagrammen - zum differentialdiagnostischen Vorgehen bei Patienten mit Lidschwellung gegeben werden . Hierbei erweist sich die subjektive Symptomatik ( Schmerzen , Juckreiz ) als sinnvolles Orientierungskriterium . Die Erkrankungen werden , nach Inzidenz gereiht , in tabellarischer Form charakterisiert . Besonderes Augenmerk gilt den allergischen Ursachen fuer Lidschwellungen sowie dem Zusammenhang zwischen Lidschwellung und atrophischen Lidveraenderungen . Instructions: please typing these entity words according to sentence: Augenlidern, Oedem, Patienten, Schmerzen, Juckreiz, Inzidenz Options: umlsterm
[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
An den Augenlidern manifestieren sich unterschiedlichste Erkrankungen . Ein haeufiges Symptom dieser Region ist die Schwellung , der wiederum oft ein Oedem zugrundeliegt . Neben einer Beschreibung der pathophysiologischen und anatomischen Grundlagen soll im vorliegenden Text vor allem eine praktische Anleitung - unter anderem mit Flussdiagrammen - zum differentialdiagnostischen Vorgehen bei Patienten mit Lidschwellung gegeben werden . Hierbei erweist sich die subjektive Symptomatik ( Schmerzen , Juckreiz ) als sinnvolles Orientierungskriterium . Die Erkrankungen werden , nach Inzidenz gereiht , in tabellarischer Form charakterisiert . Besonderes Augenmerk gilt den allergischen Ursachen fuer Lidschwellungen sowie dem Zusammenhang zwischen Lidschwellung und atrophischen Lidveraenderungen .
[ "An", "den", "Augenlidern", "manifestieren", "sich", "unterschiedlichste", "Erkrankungen", ".", "Ein", "haeufiges", "Symptom", "dieser", "Region", "ist", "die", "Schwellung", ",", "der", "wiederum", "oft", "ein", "Oedem", "zugrundeliegt", ".", "Neben", "einer", "Beschreibung", "der", "pathophysiologischen", "und", "anatomischen", "Grundlagen", "soll", "im", "vorliegenden", "Text", "vor", "allem", "eine", "praktische", "Anleitung", "-", "unter", "anderem", "mit", "Flussdiagrammen", "-", "zum", "differentialdiagnostischen", "Vorgehen", "bei", "Patienten", "mit", "Lidschwellung", "gegeben", "werden", ".", "Hierbei", "erweist", "sich", "die", "subjektive", "Symptomatik", "(", "Schmerzen", ",", "Juckreiz", ")", "als", "sinnvolles", "Orientierungskriterium", ".", "Die", "Erkrankungen", "werden", ",", "nach", "Inzidenz", "gereiht", ",", "in", "tabellarischer", "Form", "charakterisiert", ".", "Besonderes", "Augenmerk", "gilt", "den", "allergischen", "Ursachen", "fuer", "Lidschwellungen", "sowie", "dem", "Zusammenhang", "zwischen", "Lidschwellung", "und", "atrophischen", "Lidveraenderungen", "." ]
[ "umlsterm" ]
Augenlidern, Oedem, Patienten, Schmerzen, Juckreiz, Inzidenz
DerHautarzt.60470002.ger.abstr_task2
Sentence: An den Augenlidern manifestieren sich unterschiedlichste Erkrankungen . Ein haeufiges Symptom dieser Region ist die Schwellung , der wiederum oft ein Oedem zugrundeliegt . Neben einer Beschreibung der pathophysiologischen und anatomischen Grundlagen soll im vorliegenden Text vor allem eine praktische Anleitung - unter anderem mit Flussdiagrammen - zum differentialdiagnostischen Vorgehen bei Patienten mit Lidschwellung gegeben werden . Hierbei erweist sich die subjektive Symptomatik ( Schmerzen , Juckreiz ) als sinnvolles Orientierungskriterium . Die Erkrankungen werden , nach Inzidenz gereiht , in tabellarischer Form charakterisiert . Besonderes Augenmerk gilt den allergischen Ursachen fuer Lidschwellungen sowie dem Zusammenhang zwischen Lidschwellung und atrophischen Lidveraenderungen . Instructions: please extract entity words from the input sentence
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An den Augenlidern manifestieren sich unterschiedlichste Erkrankungen . Ein haeufiges Symptom dieser Region ist die Schwellung , der wiederum oft ein Oedem zugrundeliegt . Neben einer Beschreibung der pathophysiologischen und anatomischen Grundlagen soll im vorliegenden Text vor allem eine praktische Anleitung - unter anderem mit Flussdiagrammen - zum differentialdiagnostischen Vorgehen bei Patienten mit Lidschwellung gegeben werden . Hierbei erweist sich die subjektive Symptomatik ( Schmerzen , Juckreiz ) als sinnvolles Orientierungskriterium . Die Erkrankungen werden , nach Inzidenz gereiht , in tabellarischer Form charakterisiert . Besonderes Augenmerk gilt den allergischen Ursachen fuer Lidschwellungen sowie dem Zusammenhang zwischen Lidschwellung und atrophischen Lidveraenderungen .
[ "An", "den", "Augenlidern", "manifestieren", "sich", "unterschiedlichste", "Erkrankungen", ".", "Ein", "haeufiges", "Symptom", "dieser", "Region", "ist", "die", "Schwellung", ",", "der", "wiederum", "oft", "ein", "Oedem", "zugrundeliegt", ".", "Neben", "einer", "Beschreibung", "der", "pathophysiologischen", "und", "anatomischen", "Grundlagen", "soll", "im", "vorliegenden", "Text", "vor", "allem", "eine", "praktische", "Anleitung", "-", "unter", "anderem", "mit", "Flussdiagrammen", "-", "zum", "differentialdiagnostischen", "Vorgehen", "bei", "Patienten", "mit", "Lidschwellung", "gegeben", "werden", ".", "Hierbei", "erweist", "sich", "die", "subjektive", "Symptomatik", "(", "Schmerzen", ",", "Juckreiz", ")", "als", "sinnvolles", "Orientierungskriterium", ".", "Die", "Erkrankungen", "werden", ",", "nach", "Inzidenz", "gereiht", ",", "in", "tabellarischer", "Form", "charakterisiert", ".", "Besonderes", "Augenmerk", "gilt", "den", "allergischen", "Ursachen", "fuer", "Lidschwellungen", "sowie", "dem", "Zusammenhang", "zwischen", "Lidschwellung", "und", "atrophischen", "Lidveraenderungen", "." ]
[ "umlsterm" ]
ASP is a protein, glucose is a compound
DS.d775_task0
Sentence: Acylation-stimulating protein (ASP) has been shown to positively stimulate fatty acid esterification and glucose uptake in adipocytes. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein
[ "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O" ]
Acylation-stimulating protein (ASP) has been shown to positively stimulate fatty acid esterification and glucose uptake in adipocytes.
[ "Acylation", "-", "stimulating", "protein", "(", "ASP", ")", "has", "been", "shown", "to", "positively", "stimulate", "fatty", "acid", "esterification", "and", "glucose", "uptake", "in", "adipocytes", "." ]
[ "compound", "protein" ]
ASP is a protein, glucose is a compound
DS.d775_task1
Sentence: Acylation-stimulating protein (ASP) has been shown to positively stimulate fatty acid esterification and glucose uptake in adipocytes. Instructions: please typing these entity words according to sentence: ASP, glucose Options: compound, protein
[ "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O" ]
Acylation-stimulating protein (ASP) has been shown to positively stimulate fatty acid esterification and glucose uptake in adipocytes.
[ "Acylation", "-", "stimulating", "protein", "(", "ASP", ")", "has", "been", "shown", "to", "positively", "stimulate", "fatty", "acid", "esterification", "and", "glucose", "uptake", "in", "adipocytes", "." ]
[ "compound", "protein" ]
ASP, glucose
DS.d775_task2
Sentence: Acylation-stimulating protein (ASP) has been shown to positively stimulate fatty acid esterification and glucose uptake in adipocytes. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O" ]
Acylation-stimulating protein (ASP) has been shown to positively stimulate fatty acid esterification and glucose uptake in adipocytes.
[ "Acylation", "-", "stimulating", "protein", "(", "ASP", ")", "has", "been", "shown", "to", "positively", "stimulate", "fatty", "acid", "esterification", "and", "glucose", "uptake", "in", "adipocytes", "." ]
[ "compound", "protein" ]
Therapie is an umlsterm, Prothesenmodellen is an umlsterm, Talentsystem is an umlsterm, Methode is an umlsterm, maennliche is an umlsterm, Patienten is an umlsterm, weibliche is an umlsterm, therapiebeduerftigen is an umlsterm, Rohrprothese is an umlsterm, Talentprothese is an umlsterm, Rohrprothese is an umlsterm, Prothesenmodelle is an umlsterm, radiologischen is an umlsterm, Operationssaal is an umlsterm, Spaetkomplikationen is an umlsterm
Gefaesschirurgie.90040213.ger.abstr_task0
Sentence: Ziel : Die Erfahrungen endoluminaler Therapie von abdominellen , infrarenalen Aortenaneurysmen mit 2 unterschiedlichen Prothesenmodellen werden berichtet Vanguard- und Talentsystem ) . ( Material und Methode : Es wurden 33 maennliche Patienten und 1 weibliche Patientin im Alter von 52-81 Jahren mit therapiebeduerftigen , infrarenalen Aortenaneurysmen behandelt . 23 mal wurde eine Vanguardprothese implantiert ( 19 mal Bifurkations- , 4 mal Rohrprothese 11 mal ) , eine Talentprothese ( 7 mal Bifurkations- , 4 mal Rohrprothese ) . Die Auswahl der Prothesenmodelle erfolgte nach den benoetigten und verfuegbaren Dimensionen . Die Eingriffe wurden in Allgemeinnarkose im radiologischen Operationssaal durchgefuehrt . Ergebnisse : Der primaere technische Erfolg betrug 85,3% , der sekundaere 91,1% . Der primaere und sekundaere klinische Erfolg war 61,7 und 79,4% . In einem Beobachtungszeitraum von 22 Monaten kam es zu 7 Spaetkomplikationen , wobei 3 mal eine offene Operation notwendig wurde . Schlussfolgerung : Mit beiden Systemen konnten die Ergebnisse der offenen Operation nicht erreicht werden Vor- und Nachteile , der Systeme erscheinen z.Z. ausgewogen . Beide Systeme sind verbesserungsbeduerftig . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Ziel : Die Erfahrungen endoluminaler Therapie von abdominellen , infrarenalen Aortenaneurysmen mit 2 unterschiedlichen Prothesenmodellen werden berichtet Vanguard- und Talentsystem ) . ( Material und Methode : Es wurden 33 maennliche Patienten und 1 weibliche Patientin im Alter von 52-81 Jahren mit therapiebeduerftigen , infrarenalen Aortenaneurysmen behandelt . 23 mal wurde eine Vanguardprothese implantiert ( 19 mal Bifurkations- , 4 mal Rohrprothese 11 mal ) , eine Talentprothese ( 7 mal Bifurkations- , 4 mal Rohrprothese ) . Die Auswahl der Prothesenmodelle erfolgte nach den benoetigten und verfuegbaren Dimensionen . Die Eingriffe wurden in Allgemeinnarkose im radiologischen Operationssaal durchgefuehrt . Ergebnisse : Der primaere technische Erfolg betrug 85,3% , der sekundaere 91,1% . Der primaere und sekundaere klinische Erfolg war 61,7 und 79,4% . In einem Beobachtungszeitraum von 22 Monaten kam es zu 7 Spaetkomplikationen , wobei 3 mal eine offene Operation notwendig wurde . Schlussfolgerung : Mit beiden Systemen konnten die Ergebnisse der offenen Operation nicht erreicht werden Vor- und Nachteile , der Systeme erscheinen z.Z. ausgewogen . Beide Systeme sind verbesserungsbeduerftig .
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[ "umlsterm" ]
Therapie is an umlsterm, Prothesenmodellen is an umlsterm, Talentsystem is an umlsterm, Methode is an umlsterm, maennliche is an umlsterm, Patienten is an umlsterm, weibliche is an umlsterm, therapiebeduerftigen is an umlsterm, Rohrprothese is an umlsterm, Talentprothese is an umlsterm, Rohrprothese is an umlsterm, Prothesenmodelle is an umlsterm, radiologischen is an umlsterm, Operationssaal is an umlsterm, Spaetkomplikationen is an umlsterm
Gefaesschirurgie.90040213.ger.abstr_task1
Sentence: Ziel : Die Erfahrungen endoluminaler Therapie von abdominellen , infrarenalen Aortenaneurysmen mit 2 unterschiedlichen Prothesenmodellen werden berichtet Vanguard- und Talentsystem ) . ( Material und Methode : Es wurden 33 maennliche Patienten und 1 weibliche Patientin im Alter von 52-81 Jahren mit therapiebeduerftigen , infrarenalen Aortenaneurysmen behandelt . 23 mal wurde eine Vanguardprothese implantiert ( 19 mal Bifurkations- , 4 mal Rohrprothese 11 mal ) , eine Talentprothese ( 7 mal Bifurkations- , 4 mal Rohrprothese ) . Die Auswahl der Prothesenmodelle erfolgte nach den benoetigten und verfuegbaren Dimensionen . Die Eingriffe wurden in Allgemeinnarkose im radiologischen Operationssaal durchgefuehrt . Ergebnisse : Der primaere technische Erfolg betrug 85,3% , der sekundaere 91,1% . Der primaere und sekundaere klinische Erfolg war 61,7 und 79,4% . In einem Beobachtungszeitraum von 22 Monaten kam es zu 7 Spaetkomplikationen , wobei 3 mal eine offene Operation notwendig wurde . Schlussfolgerung : Mit beiden Systemen konnten die Ergebnisse der offenen Operation nicht erreicht werden Vor- und Nachteile , der Systeme erscheinen z.Z. ausgewogen . Beide Systeme sind verbesserungsbeduerftig . Instructions: please typing these entity words according to sentence: Therapie, Prothesenmodellen, Talentsystem, Methode, maennliche, Patienten, weibliche, therapiebeduerftigen, Rohrprothese, Talentprothese, Rohrprothese, Prothesenmodelle, radiologischen, Operationssaal, Spaetkomplikationen Options: umlsterm
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Ziel : Die Erfahrungen endoluminaler Therapie von abdominellen , infrarenalen Aortenaneurysmen mit 2 unterschiedlichen Prothesenmodellen werden berichtet Vanguard- und Talentsystem ) . ( Material und Methode : Es wurden 33 maennliche Patienten und 1 weibliche Patientin im Alter von 52-81 Jahren mit therapiebeduerftigen , infrarenalen Aortenaneurysmen behandelt . 23 mal wurde eine Vanguardprothese implantiert ( 19 mal Bifurkations- , 4 mal Rohrprothese 11 mal ) , eine Talentprothese ( 7 mal Bifurkations- , 4 mal Rohrprothese ) . Die Auswahl der Prothesenmodelle erfolgte nach den benoetigten und verfuegbaren Dimensionen . Die Eingriffe wurden in Allgemeinnarkose im radiologischen Operationssaal durchgefuehrt . Ergebnisse : Der primaere technische Erfolg betrug 85,3% , der sekundaere 91,1% . Der primaere und sekundaere klinische Erfolg war 61,7 und 79,4% . In einem Beobachtungszeitraum von 22 Monaten kam es zu 7 Spaetkomplikationen , wobei 3 mal eine offene Operation notwendig wurde . Schlussfolgerung : Mit beiden Systemen konnten die Ergebnisse der offenen Operation nicht erreicht werden Vor- und Nachteile , der Systeme erscheinen z.Z. ausgewogen . Beide Systeme sind verbesserungsbeduerftig .
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[ "umlsterm" ]
Therapie, Prothesenmodellen, Talentsystem, Methode, maennliche, Patienten, weibliche, therapiebeduerftigen, Rohrprothese, Talentprothese, Rohrprothese, Prothesenmodelle, radiologischen, Operationssaal, Spaetkomplikationen
Gefaesschirurgie.90040213.ger.abstr_task2
Sentence: Ziel : Die Erfahrungen endoluminaler Therapie von abdominellen , infrarenalen Aortenaneurysmen mit 2 unterschiedlichen Prothesenmodellen werden berichtet Vanguard- und Talentsystem ) . ( Material und Methode : Es wurden 33 maennliche Patienten und 1 weibliche Patientin im Alter von 52-81 Jahren mit therapiebeduerftigen , infrarenalen Aortenaneurysmen behandelt . 23 mal wurde eine Vanguardprothese implantiert ( 19 mal Bifurkations- , 4 mal Rohrprothese 11 mal ) , eine Talentprothese ( 7 mal Bifurkations- , 4 mal Rohrprothese ) . Die Auswahl der Prothesenmodelle erfolgte nach den benoetigten und verfuegbaren Dimensionen . Die Eingriffe wurden in Allgemeinnarkose im radiologischen Operationssaal durchgefuehrt . Ergebnisse : Der primaere technische Erfolg betrug 85,3% , der sekundaere 91,1% . Der primaere und sekundaere klinische Erfolg war 61,7 und 79,4% . In einem Beobachtungszeitraum von 22 Monaten kam es zu 7 Spaetkomplikationen , wobei 3 mal eine offene Operation notwendig wurde . Schlussfolgerung : Mit beiden Systemen konnten die Ergebnisse der offenen Operation nicht erreicht werden Vor- und Nachteile , der Systeme erscheinen z.Z. ausgewogen . Beide Systeme sind verbesserungsbeduerftig . Instructions: please extract entity words from the input sentence
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Ziel : Die Erfahrungen endoluminaler Therapie von abdominellen , infrarenalen Aortenaneurysmen mit 2 unterschiedlichen Prothesenmodellen werden berichtet Vanguard- und Talentsystem ) . ( Material und Methode : Es wurden 33 maennliche Patienten und 1 weibliche Patientin im Alter von 52-81 Jahren mit therapiebeduerftigen , infrarenalen Aortenaneurysmen behandelt . 23 mal wurde eine Vanguardprothese implantiert ( 19 mal Bifurkations- , 4 mal Rohrprothese 11 mal ) , eine Talentprothese ( 7 mal Bifurkations- , 4 mal Rohrprothese ) . Die Auswahl der Prothesenmodelle erfolgte nach den benoetigten und verfuegbaren Dimensionen . Die Eingriffe wurden in Allgemeinnarkose im radiologischen Operationssaal durchgefuehrt . Ergebnisse : Der primaere technische Erfolg betrug 85,3% , der sekundaere 91,1% . Der primaere und sekundaere klinische Erfolg war 61,7 und 79,4% . In einem Beobachtungszeitraum von 22 Monaten kam es zu 7 Spaetkomplikationen , wobei 3 mal eine offene Operation notwendig wurde . Schlussfolgerung : Mit beiden Systemen konnten die Ergebnisse der offenen Operation nicht erreicht werden Vor- und Nachteile , der Systeme erscheinen z.Z. ausgewogen . Beide Systeme sind verbesserungsbeduerftig .
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[ "umlsterm" ]
bupivacaine is a Intervention_Pharmacological, sufentanil is a Intervention_Pharmacological, spinal - epidural vs . epidural is a Intervention_Pharmacological, 113 is a Participant_Sample-size, women is a Participant_Sex, bupivacaine 0.25 % 1 mL is a Intervention_Pharmacological, sufentanil 5 microg is a Intervention_Pharmacological, bupivacaine 0.125 % is a Intervention_Pharmacological, epinephrine 2.5 microg mL ( -1 ) is a Intervention_Pharmacological, sufentanil 7.5 microg is a Intervention_Pharmacological, In both cases this was followed by patient - controlled epidural analgesia with bupivacaine 0.125 % is a Intervention_Pharmacological, sufentanil 0.25 microg mL ( -1 ) ) is a Intervention_Pharmacological, quality of analgesia is a Outcome_Other, side - effects is a Outcome_Adverse-effects, unilateral analgesia is a Outcome_Physical, characteristics of labour is a Outcome_Other, incidence of posterior presentation is a Outcome_Adverse-effects, pruritus is a Outcome_Adverse-effects, hypotension is a Outcome_Adverse-effects, somnolence is a Outcome_Adverse-effects, nausea is a Outcome_Adverse-effects, meningitis is a Outcome_Adverse-effects, during labour is a Participant_Condition
16689_task0
Sentence: Perispinal analgesia for labour followed by patient-controlled infusion with bupivacaine and sufentanil : combined spinal-epidural vs. epidural analgesia alone . BACKGROUND AND OBJECTIVE Combined spinal-epidural is an alternative technique to epidural analgesia for labour , but its benefits are not clearly identified . METHODS A prospective , blinded , randomized study was undertaken involving 113 women attending a university hospital obstetric department . Analgesia was initiated with intrathecal bupivacaine 0.25 % 1 mL + sufentanil 5 microg in the combined spinal-epidural group ( n = 54 ) , and with bupivacaine 0.125 % + epinephrine 2.5 microg mL ( -1 ) + sufentanil 7.5 microg in the epidural group ( n = 59 ) . In both cases this was followed by patient-controlled epidural analgesia with bupivacaine 0.125 % ( + sufentanil 0.25 microg mL ( -1 ) ) . Duration of labour , quality of analgesia and side-effects were compared between groups . RESULTS In the combined spinal-epidural group , the onset of analgesia was faster ( 5 vs. 15 min , P < 0.001 ) , the consumption of bupivacaine was lower ( 7.5 vs. 11.3 mg h ( -1 ) , P = 0.003 ) and there was less unilateral analgesia ( 14.8 % vs. 40.7 % , P = 0.002 ) than in the epidural group . The characteristics of labour were similar in both groups . However , in the combined spinal-epidural group , there was a higher incidence of posterior presentation ( 25.9 % vs. 10 % , P = 0.03 ) , pruritus ( P < 0.001 ) , hypotension ( P = 0.002 ) , somnolence ( P = 0.01 ) , nausea ( P = 0.02 ) and one case of meningitis . CONCLUSIONS The combined spinal-epidural technique provided more effective analgesia during labour than epidural analgesia alone but offered no other advantage . It induced more adverse effects and this should be considered before routinely using the combined spinal-epidural technique . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Adverse-effects, Participant_Sex, Participant_Condition, Outcome_Physical, Participant_Sample-size, Outcome_Other
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Perispinal analgesia for labour followed by patient-controlled infusion with bupivacaine and sufentanil : combined spinal-epidural vs. epidural analgesia alone . BACKGROUND AND OBJECTIVE Combined spinal-epidural is an alternative technique to epidural analgesia for labour , but its benefits are not clearly identified . METHODS A prospective , blinded , randomized study was undertaken involving 113 women attending a university hospital obstetric department . Analgesia was initiated with intrathecal bupivacaine 0.25 % 1 mL + sufentanil 5 microg in the combined spinal-epidural group ( n = 54 ) , and with bupivacaine 0.125 % + epinephrine 2.5 microg mL ( -1 ) + sufentanil 7.5 microg in the epidural group ( n = 59 ) . In both cases this was followed by patient-controlled epidural analgesia with bupivacaine 0.125 % ( + sufentanil 0.25 microg mL ( -1 ) ) . Duration of labour , quality of analgesia and side-effects were compared between groups . RESULTS In the combined spinal-epidural group , the onset of analgesia was faster ( 5 vs. 15 min , P < 0.001 ) , the consumption of bupivacaine was lower ( 7.5 vs. 11.3 mg h ( -1 ) , P = 0.003 ) and there was less unilateral analgesia ( 14.8 % vs. 40.7 % , P = 0.002 ) than in the epidural group . The characteristics of labour were similar in both groups . However , in the combined spinal-epidural group , there was a higher incidence of posterior presentation ( 25.9 % vs. 10 % , P = 0.03 ) , pruritus ( P < 0.001 ) , hypotension ( P = 0.002 ) , somnolence ( P = 0.01 ) , nausea ( P = 0.02 ) and one case of meningitis . CONCLUSIONS The combined spinal-epidural technique provided more effective analgesia during labour than epidural analgesia alone but offered no other advantage . It induced more adverse effects and this should be considered before routinely using the combined spinal-epidural technique .
[ "Perispinal", "analgesia", "for", "labour", "followed", "by", "patient", "-", "controlled", "infusion", "with", "bupivacaine", "and", "sufentanil", ":", "combined", "spinal", "-", "epidural", "vs", ".", "epidural", "analgesia", "alone", ".", "BACKGROUND", "AND", "OBJECTIVE", "Combined", "spinal", "-", "epidural", "is", "an", "alternative", "technique", "to", "epidural", "analgesia", "for", "labour", ",", "but", "its", "benefits", "are", "not", "clearly", "identified", ".", "METHODS", "A", "prospective", ",", "blinded", ",", "randomized", "study", "was", "undertaken", "involving", "113", "women", "attending", "a", "university", "hospital", "obstetric", "department", ".", "Analgesia", "was", "initiated", "with", "intrathecal", "bupivacaine", "0.25", "%", "1", "mL", "+", "sufentanil", "5", "microg", "in", "the", "combined", "spinal", "-", "epidural", "group", "(", "n", "=", "54", ")", ",", "and", "with", "bupivacaine", "0.125", "%", "+", "epinephrine", "2.5", "microg", "mL", "(", "-1", ")", "+", "sufentanil", "7.5", "microg", "in", "the", "epidural", "group", "(", "n", "=", "59", ")", ".", "In", "both", "cases", "this", "was", "followed", "by", "patient", "-", "controlled", "epidural", "analgesia", "with", "bupivacaine", "0.125", "%", "(", "+", "sufentanil", "0.25", "microg", "mL", "(", "-1", ")", ")", ".", "Duration", "of", "labour", ",", "quality", "of", "analgesia", "and", "side", "-", "effects", "were", "compared", "between", "groups", ".", "RESULTS", "In", "the", "combined", "spinal", "-", "epidural", "group", ",", "the", "onset", "of", "analgesia", "was", "faster", "(", "5", "vs", ".", "15", "min", ",", "P", "<", "0.001", ")", ",", "the", "consumption", "of", "bupivacaine", "was", "lower", "(", "7.5", "vs", ".", "11.3", "mg", "h", "(", "-1", ")", ",", "P", "=", "0.003", ")", "and", "there", "was", "less", "unilateral", "analgesia", "(", "14.8", "%", "vs", ".", "40.7", "%", ",", "P", "=", "0.002", ")", "than", "in", "the", "epidural", "group", ".", "The", "characteristics", "of", "labour", "were", "similar", "in", "both", "groups", ".", "However", ",", "in", "the", "combined", "spinal", "-", "epidural", "group", ",", "there", "was", "a", "higher", "incidence", "of", "posterior", "presentation", "(", "25.9", "%", "vs", ".", "10", "%", ",", "P", "=", "0.03", ")", ",", "pruritus", "(", "P", "<", "0.001", ")", ",", "hypotension", "(", "P", "=", "0.002", ")", ",", "somnolence", "(", "P", "=", "0.01", ")", ",", "nausea", "(", "P", "=", "0.02", ")", "and", "one", "case", "of", "meningitis", ".", "CONCLUSIONS", "The", "combined", "spinal", "-", "epidural", "technique", "provided", "more", "effective", "analgesia", "during", "labour", "than", "epidural", "analgesia", "alone", "but", "offered", "no", "other", "advantage", ".", "It", "induced", "more", "adverse", "effects", "and", "this", "should", "be", "considered", "before", "routinely", "using", "the", "combined", "spinal", "-", "epidural", "technique", "." ]
[ "Intervention_Pharmacological", "Outcome_Adverse-effects", "Outcome_Other", "Outcome_Physical", "Participant_Condition", "Participant_Sex", "Participant_Sample-size" ]
bupivacaine is a Intervention_Pharmacological, sufentanil is a Intervention_Pharmacological, spinal - epidural vs . epidural is a Intervention_Pharmacological, 113 is a Participant_Sample-size, women is a Participant_Sex, bupivacaine 0.25 % 1 mL is a Intervention_Pharmacological, sufentanil 5 microg is a Intervention_Pharmacological, bupivacaine 0.125 % is a Intervention_Pharmacological, epinephrine 2.5 microg mL ( -1 ) is a Intervention_Pharmacological, sufentanil 7.5 microg is a Intervention_Pharmacological, In both cases this was followed by patient - controlled epidural analgesia with bupivacaine 0.125 % is a Intervention_Pharmacological, sufentanil 0.25 microg mL ( -1 ) ) is a Intervention_Pharmacological, quality of analgesia is a Outcome_Other, side - effects is a Outcome_Adverse-effects, unilateral analgesia is a Outcome_Physical, characteristics of labour is a Outcome_Other, incidence of posterior presentation is a Outcome_Adverse-effects, pruritus is a Outcome_Adverse-effects, hypotension is a Outcome_Adverse-effects, somnolence is a Outcome_Adverse-effects, nausea is a Outcome_Adverse-effects, meningitis is a Outcome_Adverse-effects, during labour is a Participant_Condition
16689_task1
Sentence: Perispinal analgesia for labour followed by patient-controlled infusion with bupivacaine and sufentanil : combined spinal-epidural vs. epidural analgesia alone . BACKGROUND AND OBJECTIVE Combined spinal-epidural is an alternative technique to epidural analgesia for labour , but its benefits are not clearly identified . METHODS A prospective , blinded , randomized study was undertaken involving 113 women attending a university hospital obstetric department . Analgesia was initiated with intrathecal bupivacaine 0.25 % 1 mL + sufentanil 5 microg in the combined spinal-epidural group ( n = 54 ) , and with bupivacaine 0.125 % + epinephrine 2.5 microg mL ( -1 ) + sufentanil 7.5 microg in the epidural group ( n = 59 ) . In both cases this was followed by patient-controlled epidural analgesia with bupivacaine 0.125 % ( + sufentanil 0.25 microg mL ( -1 ) ) . Duration of labour , quality of analgesia and side-effects were compared between groups . RESULTS In the combined spinal-epidural group , the onset of analgesia was faster ( 5 vs. 15 min , P < 0.001 ) , the consumption of bupivacaine was lower ( 7.5 vs. 11.3 mg h ( -1 ) , P = 0.003 ) and there was less unilateral analgesia ( 14.8 % vs. 40.7 % , P = 0.002 ) than in the epidural group . The characteristics of labour were similar in both groups . However , in the combined spinal-epidural group , there was a higher incidence of posterior presentation ( 25.9 % vs. 10 % , P = 0.03 ) , pruritus ( P < 0.001 ) , hypotension ( P = 0.002 ) , somnolence ( P = 0.01 ) , nausea ( P = 0.02 ) and one case of meningitis . CONCLUSIONS The combined spinal-epidural technique provided more effective analgesia during labour than epidural analgesia alone but offered no other advantage . It induced more adverse effects and this should be considered before routinely using the combined spinal-epidural technique . Instructions: please typing these entity words according to sentence: bupivacaine, sufentanil, spinal - epidural vs . epidural, 113, women, bupivacaine 0.25 % 1 mL, sufentanil 5 microg, bupivacaine 0.125 %, epinephrine 2.5 microg mL ( -1 ), sufentanil 7.5 microg, In both cases this was followed by patient - controlled epidural analgesia with bupivacaine 0.125 %, sufentanil 0.25 microg mL ( -1 ) ), quality of analgesia, side - effects, unilateral analgesia, characteristics of labour, incidence of posterior presentation, pruritus, hypotension, somnolence, nausea, meningitis, during labour Options: Intervention_Pharmacological, Outcome_Adverse-effects, Participant_Sex, Participant_Condition, Outcome_Physical, Participant_Sample-size, Outcome_Other
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Perispinal analgesia for labour followed by patient-controlled infusion with bupivacaine and sufentanil : combined spinal-epidural vs. epidural analgesia alone . BACKGROUND AND OBJECTIVE Combined spinal-epidural is an alternative technique to epidural analgesia for labour , but its benefits are not clearly identified . METHODS A prospective , blinded , randomized study was undertaken involving 113 women attending a university hospital obstetric department . Analgesia was initiated with intrathecal bupivacaine 0.25 % 1 mL + sufentanil 5 microg in the combined spinal-epidural group ( n = 54 ) , and with bupivacaine 0.125 % + epinephrine 2.5 microg mL ( -1 ) + sufentanil 7.5 microg in the epidural group ( n = 59 ) . In both cases this was followed by patient-controlled epidural analgesia with bupivacaine 0.125 % ( + sufentanil 0.25 microg mL ( -1 ) ) . Duration of labour , quality of analgesia and side-effects were compared between groups . RESULTS In the combined spinal-epidural group , the onset of analgesia was faster ( 5 vs. 15 min , P < 0.001 ) , the consumption of bupivacaine was lower ( 7.5 vs. 11.3 mg h ( -1 ) , P = 0.003 ) and there was less unilateral analgesia ( 14.8 % vs. 40.7 % , P = 0.002 ) than in the epidural group . The characteristics of labour were similar in both groups . However , in the combined spinal-epidural group , there was a higher incidence of posterior presentation ( 25.9 % vs. 10 % , P = 0.03 ) , pruritus ( P < 0.001 ) , hypotension ( P = 0.002 ) , somnolence ( P = 0.01 ) , nausea ( P = 0.02 ) and one case of meningitis . CONCLUSIONS The combined spinal-epidural technique provided more effective analgesia during labour than epidural analgesia alone but offered no other advantage . It induced more adverse effects and this should be considered before routinely using the combined spinal-epidural technique .
[ "Perispinal", "analgesia", "for", "labour", "followed", "by", "patient", "-", "controlled", "infusion", "with", "bupivacaine", "and", "sufentanil", ":", "combined", "spinal", "-", "epidural", "vs", ".", "epidural", "analgesia", "alone", ".", "BACKGROUND", "AND", "OBJECTIVE", "Combined", "spinal", "-", "epidural", "is", "an", "alternative", "technique", "to", "epidural", "analgesia", "for", "labour", ",", "but", "its", "benefits", "are", "not", "clearly", "identified", ".", "METHODS", "A", "prospective", ",", "blinded", ",", "randomized", "study", "was", "undertaken", "involving", "113", "women", "attending", "a", "university", "hospital", "obstetric", "department", ".", "Analgesia", "was", "initiated", "with", "intrathecal", "bupivacaine", "0.25", "%", "1", "mL", "+", "sufentanil", "5", "microg", "in", "the", "combined", "spinal", "-", "epidural", "group", "(", "n", "=", "54", ")", ",", "and", "with", "bupivacaine", "0.125", "%", "+", "epinephrine", "2.5", "microg", "mL", "(", "-1", ")", "+", "sufentanil", "7.5", "microg", "in", "the", "epidural", "group", "(", "n", "=", "59", ")", ".", "In", "both", "cases", "this", "was", "followed", "by", "patient", "-", "controlled", "epidural", "analgesia", "with", "bupivacaine", "0.125", "%", "(", "+", "sufentanil", "0.25", "microg", "mL", "(", "-1", ")", ")", ".", "Duration", "of", "labour", ",", "quality", "of", "analgesia", "and", "side", "-", "effects", "were", "compared", "between", "groups", ".", "RESULTS", "In", "the", "combined", "spinal", "-", "epidural", "group", ",", "the", "onset", "of", "analgesia", "was", "faster", "(", "5", "vs", ".", "15", "min", ",", "P", "<", "0.001", ")", ",", "the", "consumption", "of", "bupivacaine", "was", "lower", "(", "7.5", "vs", ".", "11.3", "mg", "h", "(", "-1", ")", ",", "P", "=", "0.003", ")", "and", "there", "was", "less", "unilateral", "analgesia", "(", "14.8", "%", "vs", ".", "40.7", "%", ",", "P", "=", "0.002", ")", "than", "in", "the", "epidural", "group", ".", "The", "characteristics", "of", "labour", "were", "similar", "in", "both", "groups", ".", "However", ",", "in", "the", "combined", "spinal", "-", "epidural", "group", ",", "there", "was", "a", "higher", "incidence", "of", "posterior", "presentation", "(", "25.9", "%", "vs", ".", "10", "%", ",", "P", "=", "0.03", ")", ",", "pruritus", "(", "P", "<", "0.001", ")", ",", "hypotension", "(", "P", "=", "0.002", ")", ",", "somnolence", "(", "P", "=", "0.01", ")", ",", "nausea", "(", "P", "=", "0.02", ")", "and", "one", "case", "of", "meningitis", ".", "CONCLUSIONS", "The", "combined", "spinal", "-", "epidural", "technique", "provided", "more", "effective", "analgesia", "during", "labour", "than", "epidural", "analgesia", "alone", "but", "offered", "no", "other", "advantage", ".", "It", "induced", "more", "adverse", "effects", "and", "this", "should", "be", "considered", "before", "routinely", "using", "the", "combined", "spinal", "-", "epidural", "technique", "." ]
[ "Intervention_Pharmacological", "Outcome_Adverse-effects", "Outcome_Other", "Outcome_Physical", "Participant_Condition", "Participant_Sex", "Participant_Sample-size" ]
bupivacaine, sufentanil, spinal - epidural vs . epidural, 113, women, bupivacaine 0.25 % 1 mL, sufentanil 5 microg, bupivacaine 0.125 %, epinephrine 2.5 microg mL ( -1 ), sufentanil 7.5 microg, In both cases this was followed by patient - controlled epidural analgesia with bupivacaine 0.125 %, sufentanil 0.25 microg mL ( -1 ) ), quality of analgesia, side - effects, unilateral analgesia, characteristics of labour, incidence of posterior presentation, pruritus, hypotension, somnolence, nausea, meningitis, during labour
16689_task2
Sentence: Perispinal analgesia for labour followed by patient-controlled infusion with bupivacaine and sufentanil : combined spinal-epidural vs. epidural analgesia alone . BACKGROUND AND OBJECTIVE Combined spinal-epidural is an alternative technique to epidural analgesia for labour , but its benefits are not clearly identified . METHODS A prospective , blinded , randomized study was undertaken involving 113 women attending a university hospital obstetric department . Analgesia was initiated with intrathecal bupivacaine 0.25 % 1 mL + sufentanil 5 microg in the combined spinal-epidural group ( n = 54 ) , and with bupivacaine 0.125 % + epinephrine 2.5 microg mL ( -1 ) + sufentanil 7.5 microg in the epidural group ( n = 59 ) . In both cases this was followed by patient-controlled epidural analgesia with bupivacaine 0.125 % ( + sufentanil 0.25 microg mL ( -1 ) ) . Duration of labour , quality of analgesia and side-effects were compared between groups . RESULTS In the combined spinal-epidural group , the onset of analgesia was faster ( 5 vs. 15 min , P < 0.001 ) , the consumption of bupivacaine was lower ( 7.5 vs. 11.3 mg h ( -1 ) , P = 0.003 ) and there was less unilateral analgesia ( 14.8 % vs. 40.7 % , P = 0.002 ) than in the epidural group . The characteristics of labour were similar in both groups . However , in the combined spinal-epidural group , there was a higher incidence of posterior presentation ( 25.9 % vs. 10 % , P = 0.03 ) , pruritus ( P < 0.001 ) , hypotension ( P = 0.002 ) , somnolence ( P = 0.01 ) , nausea ( P = 0.02 ) and one case of meningitis . CONCLUSIONS The combined spinal-epidural technique provided more effective analgesia during labour than epidural analgesia alone but offered no other advantage . It induced more adverse effects and this should be considered before routinely using the combined spinal-epidural technique . Instructions: please extract entity words from the input sentence
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Perispinal analgesia for labour followed by patient-controlled infusion with bupivacaine and sufentanil : combined spinal-epidural vs. epidural analgesia alone . BACKGROUND AND OBJECTIVE Combined spinal-epidural is an alternative technique to epidural analgesia for labour , but its benefits are not clearly identified . METHODS A prospective , blinded , randomized study was undertaken involving 113 women attending a university hospital obstetric department . Analgesia was initiated with intrathecal bupivacaine 0.25 % 1 mL + sufentanil 5 microg in the combined spinal-epidural group ( n = 54 ) , and with bupivacaine 0.125 % + epinephrine 2.5 microg mL ( -1 ) + sufentanil 7.5 microg in the epidural group ( n = 59 ) . In both cases this was followed by patient-controlled epidural analgesia with bupivacaine 0.125 % ( + sufentanil 0.25 microg mL ( -1 ) ) . Duration of labour , quality of analgesia and side-effects were compared between groups . RESULTS In the combined spinal-epidural group , the onset of analgesia was faster ( 5 vs. 15 min , P < 0.001 ) , the consumption of bupivacaine was lower ( 7.5 vs. 11.3 mg h ( -1 ) , P = 0.003 ) and there was less unilateral analgesia ( 14.8 % vs. 40.7 % , P = 0.002 ) than in the epidural group . The characteristics of labour were similar in both groups . However , in the combined spinal-epidural group , there was a higher incidence of posterior presentation ( 25.9 % vs. 10 % , P = 0.03 ) , pruritus ( P < 0.001 ) , hypotension ( P = 0.002 ) , somnolence ( P = 0.01 ) , nausea ( P = 0.02 ) and one case of meningitis . CONCLUSIONS The combined spinal-epidural technique provided more effective analgesia during labour than epidural analgesia alone but offered no other advantage . It induced more adverse effects and this should be considered before routinely using the combined spinal-epidural technique .
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[ "Intervention_Pharmacological", "Outcome_Adverse-effects", "Outcome_Other", "Outcome_Physical", "Participant_Condition", "Participant_Sex", "Participant_Sample-size" ]
patient - controlled sedation with midazolam . is a Participant_Condition, 26 is a Participant_Sample-size, bilateral lower third molar surgery is a Participant_Condition, degree of sedation is a Outcome_Physical, operating conditions is a Outcome_Other, vital signs is a Outcome_Physical, loss of verbal contact . is a Outcome_Other
81899_task0
Sentence: A comparison of 1- and 3-minute lockout periods during patient-controlled sedation with midazolam . PURPOSE The maximum effect of midazolam injected intravenously occurs in about 3 minutes . Patient-controlled sedation carried out with 1-mg increments of midazolam at 3-minute intervals provides comparable conditions to that of doctor-controlled sedation carried out with 1-mg increments at 1-minute intervals , except for the longer duration taken for the patients to achieve satisfactory sedation prior to surgery . The purpose of this study was to find out how safe it would be to shorten the interval of increments of midazolam to 1 minute in patient-controlled sedation . PATIENTS AND METHODS In a randomized crossover study , 26 patients undergoing bilateral lower third molar surgery at two visits had patient-controlled sedation with 1 mg midazolam increments at 1-minute or 3-minute intervals at one visit and the alternative at the other visit . RESULTS The time taken for patients to achieve a degree of sedation that they thought was sufficient to tolerate the surgery was significantly longer when the increment interval was 3 minutes ( t = -4.8 ; P < .05 ) . Both techniques provided good operating conditions , stable vital signs , mild to moderate sedation , without loss of verbal contact . CONCLUSION A significant majority preferred the sedation technique with 1-minute increment intervals ( chi 2 = 4.6 ; P < .05 ) . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Outcome_Other, Outcome_Physical, Participant_Condition, Participant_Sample-size
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
A comparison of 1- and 3-minute lockout periods during patient-controlled sedation with midazolam . PURPOSE The maximum effect of midazolam injected intravenously occurs in about 3 minutes . Patient-controlled sedation carried out with 1-mg increments of midazolam at 3-minute intervals provides comparable conditions to that of doctor-controlled sedation carried out with 1-mg increments at 1-minute intervals , except for the longer duration taken for the patients to achieve satisfactory sedation prior to surgery . The purpose of this study was to find out how safe it would be to shorten the interval of increments of midazolam to 1 minute in patient-controlled sedation . PATIENTS AND METHODS In a randomized crossover study , 26 patients undergoing bilateral lower third molar surgery at two visits had patient-controlled sedation with 1 mg midazolam increments at 1-minute or 3-minute intervals at one visit and the alternative at the other visit . RESULTS The time taken for patients to achieve a degree of sedation that they thought was sufficient to tolerate the surgery was significantly longer when the increment interval was 3 minutes ( t = -4.8 ; P < .05 ) . Both techniques provided good operating conditions , stable vital signs , mild to moderate sedation , without loss of verbal contact . CONCLUSION A significant majority preferred the sedation technique with 1-minute increment intervals ( chi 2 = 4.6 ; P < .05 ) .
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[ "Participant_Condition", "Intervention_Pharmacological", "Outcome_Other", "Outcome_Physical", "Participant_Sample-size" ]
patient - controlled sedation with midazolam . is a Participant_Condition, 26 is a Participant_Sample-size, bilateral lower third molar surgery is a Participant_Condition, degree of sedation is a Outcome_Physical, operating conditions is a Outcome_Other, vital signs is a Outcome_Physical, loss of verbal contact . is a Outcome_Other
81899_task1
Sentence: A comparison of 1- and 3-minute lockout periods during patient-controlled sedation with midazolam . PURPOSE The maximum effect of midazolam injected intravenously occurs in about 3 minutes . Patient-controlled sedation carried out with 1-mg increments of midazolam at 3-minute intervals provides comparable conditions to that of doctor-controlled sedation carried out with 1-mg increments at 1-minute intervals , except for the longer duration taken for the patients to achieve satisfactory sedation prior to surgery . The purpose of this study was to find out how safe it would be to shorten the interval of increments of midazolam to 1 minute in patient-controlled sedation . PATIENTS AND METHODS In a randomized crossover study , 26 patients undergoing bilateral lower third molar surgery at two visits had patient-controlled sedation with 1 mg midazolam increments at 1-minute or 3-minute intervals at one visit and the alternative at the other visit . RESULTS The time taken for patients to achieve a degree of sedation that they thought was sufficient to tolerate the surgery was significantly longer when the increment interval was 3 minutes ( t = -4.8 ; P < .05 ) . Both techniques provided good operating conditions , stable vital signs , mild to moderate sedation , without loss of verbal contact . CONCLUSION A significant majority preferred the sedation technique with 1-minute increment intervals ( chi 2 = 4.6 ; P < .05 ) . Instructions: please typing these entity words according to sentence: patient - controlled sedation with midazolam ., 26, bilateral lower third molar surgery, degree of sedation, operating conditions, vital signs, loss of verbal contact . Options: Outcome_Other, Outcome_Physical, Participant_Condition, Participant_Sample-size
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A comparison of 1- and 3-minute lockout periods during patient-controlled sedation with midazolam . PURPOSE The maximum effect of midazolam injected intravenously occurs in about 3 minutes . Patient-controlled sedation carried out with 1-mg increments of midazolam at 3-minute intervals provides comparable conditions to that of doctor-controlled sedation carried out with 1-mg increments at 1-minute intervals , except for the longer duration taken for the patients to achieve satisfactory sedation prior to surgery . The purpose of this study was to find out how safe it would be to shorten the interval of increments of midazolam to 1 minute in patient-controlled sedation . PATIENTS AND METHODS In a randomized crossover study , 26 patients undergoing bilateral lower third molar surgery at two visits had patient-controlled sedation with 1 mg midazolam increments at 1-minute or 3-minute intervals at one visit and the alternative at the other visit . RESULTS The time taken for patients to achieve a degree of sedation that they thought was sufficient to tolerate the surgery was significantly longer when the increment interval was 3 minutes ( t = -4.8 ; P < .05 ) . Both techniques provided good operating conditions , stable vital signs , mild to moderate sedation , without loss of verbal contact . CONCLUSION A significant majority preferred the sedation technique with 1-minute increment intervals ( chi 2 = 4.6 ; P < .05 ) .
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[ "Participant_Condition", "Intervention_Pharmacological", "Outcome_Other", "Outcome_Physical", "Participant_Sample-size" ]
patient - controlled sedation with midazolam ., 26, bilateral lower third molar surgery, degree of sedation, operating conditions, vital signs, loss of verbal contact .
81899_task2
Sentence: A comparison of 1- and 3-minute lockout periods during patient-controlled sedation with midazolam . PURPOSE The maximum effect of midazolam injected intravenously occurs in about 3 minutes . Patient-controlled sedation carried out with 1-mg increments of midazolam at 3-minute intervals provides comparable conditions to that of doctor-controlled sedation carried out with 1-mg increments at 1-minute intervals , except for the longer duration taken for the patients to achieve satisfactory sedation prior to surgery . The purpose of this study was to find out how safe it would be to shorten the interval of increments of midazolam to 1 minute in patient-controlled sedation . PATIENTS AND METHODS In a randomized crossover study , 26 patients undergoing bilateral lower third molar surgery at two visits had patient-controlled sedation with 1 mg midazolam increments at 1-minute or 3-minute intervals at one visit and the alternative at the other visit . RESULTS The time taken for patients to achieve a degree of sedation that they thought was sufficient to tolerate the surgery was significantly longer when the increment interval was 3 minutes ( t = -4.8 ; P < .05 ) . Both techniques provided good operating conditions , stable vital signs , mild to moderate sedation , without loss of verbal contact . CONCLUSION A significant majority preferred the sedation technique with 1-minute increment intervals ( chi 2 = 4.6 ; P < .05 ) . Instructions: please extract entity words from the input sentence
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A comparison of 1- and 3-minute lockout periods during patient-controlled sedation with midazolam . PURPOSE The maximum effect of midazolam injected intravenously occurs in about 3 minutes . Patient-controlled sedation carried out with 1-mg increments of midazolam at 3-minute intervals provides comparable conditions to that of doctor-controlled sedation carried out with 1-mg increments at 1-minute intervals , except for the longer duration taken for the patients to achieve satisfactory sedation prior to surgery . The purpose of this study was to find out how safe it would be to shorten the interval of increments of midazolam to 1 minute in patient-controlled sedation . PATIENTS AND METHODS In a randomized crossover study , 26 patients undergoing bilateral lower third molar surgery at two visits had patient-controlled sedation with 1 mg midazolam increments at 1-minute or 3-minute intervals at one visit and the alternative at the other visit . RESULTS The time taken for patients to achieve a degree of sedation that they thought was sufficient to tolerate the surgery was significantly longer when the increment interval was 3 minutes ( t = -4.8 ; P < .05 ) . Both techniques provided good operating conditions , stable vital signs , mild to moderate sedation , without loss of verbal contact . CONCLUSION A significant majority preferred the sedation technique with 1-minute increment intervals ( chi 2 = 4.6 ; P < .05 ) .
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[ "Participant_Condition", "Intervention_Pharmacological", "Outcome_Other", "Outcome_Physical", "Participant_Sample-size" ]
interleukin-12 is a Protein, IL-12 is a Protein, IL-12 is a Protein, IL-12 is a Protein, nitric oxide synthase is a Protein
10426995_task0
Sentence: Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. The generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system. Yet, for many pathogens, the molecules that induce IL-12 production by macrophages and the mechanisms by which they do so remain undefined. Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs). Several lipoproteins stimulated TLR-dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway. Activation of TLRs by microbial lipoproteins may initiate innate defense mechanisms against infectious pathogens. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein
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Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. The generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system. Yet, for many pathogens, the molecules that induce IL-12 production by macrophages and the mechanisms by which they do so remain undefined. Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs). Several lipoproteins stimulated TLR-dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway. Activation of TLRs by microbial lipoproteins may initiate innate defense mechanisms against infectious pathogens.
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[ "Protein" ]
interleukin-12 is a Protein, IL-12 is a Protein, IL-12 is a Protein, IL-12 is a Protein, nitric oxide synthase is a Protein
10426995_task1
Sentence: Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. The generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system. Yet, for many pathogens, the molecules that induce IL-12 production by macrophages and the mechanisms by which they do so remain undefined. Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs). Several lipoproteins stimulated TLR-dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway. Activation of TLRs by microbial lipoproteins may initiate innate defense mechanisms against infectious pathogens. Instructions: please typing these entity words according to sentence: interleukin-12, IL-12, IL-12, IL-12, nitric oxide synthase Options: Protein
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Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. The generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system. Yet, for many pathogens, the molecules that induce IL-12 production by macrophages and the mechanisms by which they do so remain undefined. Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs). Several lipoproteins stimulated TLR-dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway. Activation of TLRs by microbial lipoproteins may initiate innate defense mechanisms against infectious pathogens.
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[ "Protein" ]
interleukin-12, IL-12, IL-12, IL-12, nitric oxide synthase
10426995_task2
Sentence: Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. The generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system. Yet, for many pathogens, the molecules that induce IL-12 production by macrophages and the mechanisms by which they do so remain undefined. Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs). Several lipoproteins stimulated TLR-dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway. Activation of TLRs by microbial lipoproteins may initiate innate defense mechanisms against infectious pathogens. Instructions: please extract entity words from the input sentence
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Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. The generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system. Yet, for many pathogens, the molecules that induce IL-12 production by macrophages and the mechanisms by which they do so remain undefined. Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs). Several lipoproteins stimulated TLR-dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway. Activation of TLRs by microbial lipoproteins may initiate innate defense mechanisms against infectious pathogens.
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[ "Protein" ]
HIV long - terminal repeat is a Entity, NF - kappaB is a Entity
711_task0
Sentence: Activation of human immunodeficiency virus type 1 expression by Gardnerella vaginalis. Bacterial vaginosis (BV) is associated with an increased rate of sexual transmission of human immunodeficiency virus (HIV) type 1, and Gardnerella vaginalis is frequently isolated from the genital tracts of women with BV. G. vaginalis lysates were found to significantly stimulate HIV expression in monocytoid cells. Stimulation was significantly higher when lysates were heated at 100 degrees C for 5 min but was reduced by treatment with lysozyme or protease. G. vaginalis lysates also activated HIV expression in certain T cell lines. G. vaginalis lysates activated HIV long-terminal repeat transcription in HIV-infected cells and increased NF-kappaB binding activity, indicating an effect by G. vaginalis on HIV transcription. The activation of HIV production by G. vaginalis suggests that genital tract infection with G. vaginalis increases the risk of HIV transmission by increasing HIV expression in the genital tract. This may explain, at least in part, the increased rate of HIV transmission in women with BV. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity
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Activation of human immunodeficiency virus type 1 expression by Gardnerella vaginalis. Bacterial vaginosis (BV) is associated with an increased rate of sexual transmission of human immunodeficiency virus (HIV) type 1, and Gardnerella vaginalis is frequently isolated from the genital tracts of women with BV. G. vaginalis lysates were found to significantly stimulate HIV expression in monocytoid cells. Stimulation was significantly higher when lysates were heated at 100 degrees C for 5 min but was reduced by treatment with lysozyme or protease. G. vaginalis lysates also activated HIV expression in certain T cell lines. G. vaginalis lysates activated HIV long-terminal repeat transcription in HIV-infected cells and increased NF-kappaB binding activity, indicating an effect by G. vaginalis on HIV transcription. The activation of HIV production by G. vaginalis suggests that genital tract infection with G. vaginalis increases the risk of HIV transmission by increasing HIV expression in the genital tract. This may explain, at least in part, the increased rate of HIV transmission in women with BV.
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[ "Entity" ]
HIV long - terminal repeat is a Entity, NF - kappaB is a Entity
711_task1
Sentence: Activation of human immunodeficiency virus type 1 expression by Gardnerella vaginalis. Bacterial vaginosis (BV) is associated with an increased rate of sexual transmission of human immunodeficiency virus (HIV) type 1, and Gardnerella vaginalis is frequently isolated from the genital tracts of women with BV. G. vaginalis lysates were found to significantly stimulate HIV expression in monocytoid cells. Stimulation was significantly higher when lysates were heated at 100 degrees C for 5 min but was reduced by treatment with lysozyme or protease. G. vaginalis lysates also activated HIV expression in certain T cell lines. G. vaginalis lysates activated HIV long-terminal repeat transcription in HIV-infected cells and increased NF-kappaB binding activity, indicating an effect by G. vaginalis on HIV transcription. The activation of HIV production by G. vaginalis suggests that genital tract infection with G. vaginalis increases the risk of HIV transmission by increasing HIV expression in the genital tract. This may explain, at least in part, the increased rate of HIV transmission in women with BV. Instructions: please typing these entity words according to sentence: HIV long - terminal repeat, NF - kappaB Options: Entity
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Activation of human immunodeficiency virus type 1 expression by Gardnerella vaginalis. Bacterial vaginosis (BV) is associated with an increased rate of sexual transmission of human immunodeficiency virus (HIV) type 1, and Gardnerella vaginalis is frequently isolated from the genital tracts of women with BV. G. vaginalis lysates were found to significantly stimulate HIV expression in monocytoid cells. Stimulation was significantly higher when lysates were heated at 100 degrees C for 5 min but was reduced by treatment with lysozyme or protease. G. vaginalis lysates also activated HIV expression in certain T cell lines. G. vaginalis lysates activated HIV long-terminal repeat transcription in HIV-infected cells and increased NF-kappaB binding activity, indicating an effect by G. vaginalis on HIV transcription. The activation of HIV production by G. vaginalis suggests that genital tract infection with G. vaginalis increases the risk of HIV transmission by increasing HIV expression in the genital tract. This may explain, at least in part, the increased rate of HIV transmission in women with BV.
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[ "Entity" ]
HIV long - terminal repeat, NF - kappaB
711_task2
Sentence: Activation of human immunodeficiency virus type 1 expression by Gardnerella vaginalis. Bacterial vaginosis (BV) is associated with an increased rate of sexual transmission of human immunodeficiency virus (HIV) type 1, and Gardnerella vaginalis is frequently isolated from the genital tracts of women with BV. G. vaginalis lysates were found to significantly stimulate HIV expression in monocytoid cells. Stimulation was significantly higher when lysates were heated at 100 degrees C for 5 min but was reduced by treatment with lysozyme or protease. G. vaginalis lysates also activated HIV expression in certain T cell lines. G. vaginalis lysates activated HIV long-terminal repeat transcription in HIV-infected cells and increased NF-kappaB binding activity, indicating an effect by G. vaginalis on HIV transcription. The activation of HIV production by G. vaginalis suggests that genital tract infection with G. vaginalis increases the risk of HIV transmission by increasing HIV expression in the genital tract. This may explain, at least in part, the increased rate of HIV transmission in women with BV. Instructions: please extract entity words from the input sentence
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Activation of human immunodeficiency virus type 1 expression by Gardnerella vaginalis. Bacterial vaginosis (BV) is associated with an increased rate of sexual transmission of human immunodeficiency virus (HIV) type 1, and Gardnerella vaginalis is frequently isolated from the genital tracts of women with BV. G. vaginalis lysates were found to significantly stimulate HIV expression in monocytoid cells. Stimulation was significantly higher when lysates were heated at 100 degrees C for 5 min but was reduced by treatment with lysozyme or protease. G. vaginalis lysates also activated HIV expression in certain T cell lines. G. vaginalis lysates activated HIV long-terminal repeat transcription in HIV-infected cells and increased NF-kappaB binding activity, indicating an effect by G. vaginalis on HIV transcription. The activation of HIV production by G. vaginalis suggests that genital tract infection with G. vaginalis increases the risk of HIV transmission by increasing HIV expression in the genital tract. This may explain, at least in part, the increased rate of HIV transmission in women with BV.
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[ "Entity" ]
ATP - binding cassette transporter A1 is a GENE-Y, alpha - tocopherol is a CHEMICAL, Vitamin E is a CHEMICAL, alpha - tocopherol is a CHEMICAL, alpha - Tocopherol transfer protein is a GENE-Y, alpha - TTP is a GENE-Y, vitamin E is a CHEMICAL, alpha - tocopherol is a CHEMICAL, alpha - tocopherol is a CHEMICAL, alpha - tocopherol is a CHEMICAL, alpha - tocopherol is a CHEMICAL, alpha - tocopherol is a CHEMICAL, [ ( 3)H]alpha - tocopheryl acetate is a CHEMICAL, alpha - tocopherol transfer protein is a GENE-Y, alpha - TTP is a GENE-Y, apolipoprotein A - I is a GENE-Y, apoA - I is a GENE-Y, ATP - binding cassette transporter A1 is a GENE-Y, alpha - tocopherol is a CHEMICAL, probucol is a CHEMICAL, ABCA1 is a GENE-Y, alpha - tocopherol is a CHEMICAL, alpha - tocopherol is a CHEMICAL, probucol is a CHEMICAL, alpha - tocopherol is a CHEMICAL, ABCA1 is a GENE-Y, alpha - tocopherol is a CHEMICAL
3066_task0
Sentence: ATP-binding cassette transporter A1 is involved in hepatic alpha-tocopherol secretion. Vitamin E (alpha-tocopherol) is an essential fat-soluble nutrient with antioxidant properties. alpha-Tocopherol transfer protein (alpha-TTP), the product of the gene responsible for familial isolated vitamin E deficiency, plays an important role in maintaining the plasma alpha-tocopherol level by mediating the secretion of alpha-tocopherol by the liver. However, the mechanisms underlying hepatic alpha-tocopherol secretion are not fully understood. This study was undertaken to elucidate the mechanism of alpha-tocopherol re-efflux from hepatocytes, the cells that have the most important role in regulating plasma-alpha-tocopherol concentrations. From in vitro experiments using [(3)H]alpha-tocopheryl acetate and McARH7777 cells that stably express alpha-tocopherol transfer protein (alpha-TTP), the following results were obtained. First, addition of apolipoprotein A-I (apoA-I), a direct acceptor of the ATP-binding cassette transporter A1 (ABCA1)-secreted lipids, increased alpha-tocopherol secretion in a dose-dependent manner. Second, probucol, an antiatherogenic compound reported to be an inactivator of ABCA1 reduced hepatic alpha-tocopherol secretion. Third, ABCA1-RNAi suppressed hepatic alpha-tocopherol secretion. In a mouse in vivo experiment, addition of 1% probucol to the diet decreased plasma alpha-tocopherol concentrations. These results strongly suggest that ABCA1 is substantially involved in hepatic alpha-tocopherol secretion. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL
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ATP-binding cassette transporter A1 is involved in hepatic alpha-tocopherol secretion. Vitamin E (alpha-tocopherol) is an essential fat-soluble nutrient with antioxidant properties. alpha-Tocopherol transfer protein (alpha-TTP), the product of the gene responsible for familial isolated vitamin E deficiency, plays an important role in maintaining the plasma alpha-tocopherol level by mediating the secretion of alpha-tocopherol by the liver. However, the mechanisms underlying hepatic alpha-tocopherol secretion are not fully understood. This study was undertaken to elucidate the mechanism of alpha-tocopherol re-efflux from hepatocytes, the cells that have the most important role in regulating plasma-alpha-tocopherol concentrations. From in vitro experiments using [(3)H]alpha-tocopheryl acetate and McARH7777 cells that stably express alpha-tocopherol transfer protein (alpha-TTP), the following results were obtained. First, addition of apolipoprotein A-I (apoA-I), a direct acceptor of the ATP-binding cassette transporter A1 (ABCA1)-secreted lipids, increased alpha-tocopherol secretion in a dose-dependent manner. Second, probucol, an antiatherogenic compound reported to be an inactivator of ABCA1 reduced hepatic alpha-tocopherol secretion. Third, ABCA1-RNAi suppressed hepatic alpha-tocopherol secretion. In a mouse in vivo experiment, addition of 1% probucol to the diet decreased plasma alpha-tocopherol concentrations. These results strongly suggest that ABCA1 is substantially involved in hepatic alpha-tocopherol secretion.
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[ "GENE-Y", "CHEMICAL" ]
ATP - binding cassette transporter A1 is a GENE-Y, alpha - tocopherol is a CHEMICAL, Vitamin E is a CHEMICAL, alpha - tocopherol is a CHEMICAL, alpha - Tocopherol transfer protein is a GENE-Y, alpha - TTP is a GENE-Y, vitamin E is a CHEMICAL, alpha - tocopherol is a CHEMICAL, alpha - tocopherol is a CHEMICAL, alpha - tocopherol is a CHEMICAL, alpha - tocopherol is a CHEMICAL, alpha - tocopherol is a CHEMICAL, [ ( 3)H]alpha - tocopheryl acetate is a CHEMICAL, alpha - tocopherol transfer protein is a GENE-Y, alpha - TTP is a GENE-Y, apolipoprotein A - I is a GENE-Y, apoA - I is a GENE-Y, ATP - binding cassette transporter A1 is a GENE-Y, alpha - tocopherol is a CHEMICAL, probucol is a CHEMICAL, ABCA1 is a GENE-Y, alpha - tocopherol is a CHEMICAL, alpha - tocopherol is a CHEMICAL, probucol is a CHEMICAL, alpha - tocopherol is a CHEMICAL, ABCA1 is a GENE-Y, alpha - tocopherol is a CHEMICAL
3066_task1
Sentence: ATP-binding cassette transporter A1 is involved in hepatic alpha-tocopherol secretion. Vitamin E (alpha-tocopherol) is an essential fat-soluble nutrient with antioxidant properties. alpha-Tocopherol transfer protein (alpha-TTP), the product of the gene responsible for familial isolated vitamin E deficiency, plays an important role in maintaining the plasma alpha-tocopherol level by mediating the secretion of alpha-tocopherol by the liver. However, the mechanisms underlying hepatic alpha-tocopherol secretion are not fully understood. This study was undertaken to elucidate the mechanism of alpha-tocopherol re-efflux from hepatocytes, the cells that have the most important role in regulating plasma-alpha-tocopherol concentrations. From in vitro experiments using [(3)H]alpha-tocopheryl acetate and McARH7777 cells that stably express alpha-tocopherol transfer protein (alpha-TTP), the following results were obtained. First, addition of apolipoprotein A-I (apoA-I), a direct acceptor of the ATP-binding cassette transporter A1 (ABCA1)-secreted lipids, increased alpha-tocopherol secretion in a dose-dependent manner. Second, probucol, an antiatherogenic compound reported to be an inactivator of ABCA1 reduced hepatic alpha-tocopherol secretion. Third, ABCA1-RNAi suppressed hepatic alpha-tocopherol secretion. In a mouse in vivo experiment, addition of 1% probucol to the diet decreased plasma alpha-tocopherol concentrations. These results strongly suggest that ABCA1 is substantially involved in hepatic alpha-tocopherol secretion. Instructions: please typing these entity words according to sentence: ATP - binding cassette transporter A1, alpha - tocopherol, Vitamin E, alpha - tocopherol, alpha - Tocopherol transfer protein, alpha - TTP, vitamin E, alpha - tocopherol, alpha - tocopherol, alpha - tocopherol, alpha - tocopherol, alpha - tocopherol, [ ( 3)H]alpha - tocopheryl acetate, alpha - tocopherol transfer protein, alpha - TTP, apolipoprotein A - I, apoA - I, ATP - binding cassette transporter A1, alpha - tocopherol, probucol, ABCA1, alpha - tocopherol, alpha - tocopherol, probucol, alpha - tocopherol, ABCA1, alpha - tocopherol Options: GENE-Y, CHEMICAL
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ATP-binding cassette transporter A1 is involved in hepatic alpha-tocopherol secretion. Vitamin E (alpha-tocopherol) is an essential fat-soluble nutrient with antioxidant properties. alpha-Tocopherol transfer protein (alpha-TTP), the product of the gene responsible for familial isolated vitamin E deficiency, plays an important role in maintaining the plasma alpha-tocopherol level by mediating the secretion of alpha-tocopherol by the liver. However, the mechanisms underlying hepatic alpha-tocopherol secretion are not fully understood. This study was undertaken to elucidate the mechanism of alpha-tocopherol re-efflux from hepatocytes, the cells that have the most important role in regulating plasma-alpha-tocopherol concentrations. From in vitro experiments using [(3)H]alpha-tocopheryl acetate and McARH7777 cells that stably express alpha-tocopherol transfer protein (alpha-TTP), the following results were obtained. First, addition of apolipoprotein A-I (apoA-I), a direct acceptor of the ATP-binding cassette transporter A1 (ABCA1)-secreted lipids, increased alpha-tocopherol secretion in a dose-dependent manner. Second, probucol, an antiatherogenic compound reported to be an inactivator of ABCA1 reduced hepatic alpha-tocopherol secretion. Third, ABCA1-RNAi suppressed hepatic alpha-tocopherol secretion. In a mouse in vivo experiment, addition of 1% probucol to the diet decreased plasma alpha-tocopherol concentrations. These results strongly suggest that ABCA1 is substantially involved in hepatic alpha-tocopherol secretion.
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[ "GENE-Y", "CHEMICAL" ]
ATP - binding cassette transporter A1, alpha - tocopherol, Vitamin E, alpha - tocopherol, alpha - Tocopherol transfer protein, alpha - TTP, vitamin E, alpha - tocopherol, alpha - tocopherol, alpha - tocopherol, alpha - tocopherol, alpha - tocopherol, [ ( 3)H]alpha - tocopheryl acetate, alpha - tocopherol transfer protein, alpha - TTP, apolipoprotein A - I, apoA - I, ATP - binding cassette transporter A1, alpha - tocopherol, probucol, ABCA1, alpha - tocopherol, alpha - tocopherol, probucol, alpha - tocopherol, ABCA1, alpha - tocopherol
3066_task2
Sentence: ATP-binding cassette transporter A1 is involved in hepatic alpha-tocopherol secretion. Vitamin E (alpha-tocopherol) is an essential fat-soluble nutrient with antioxidant properties. alpha-Tocopherol transfer protein (alpha-TTP), the product of the gene responsible for familial isolated vitamin E deficiency, plays an important role in maintaining the plasma alpha-tocopherol level by mediating the secretion of alpha-tocopherol by the liver. However, the mechanisms underlying hepatic alpha-tocopherol secretion are not fully understood. This study was undertaken to elucidate the mechanism of alpha-tocopherol re-efflux from hepatocytes, the cells that have the most important role in regulating plasma-alpha-tocopherol concentrations. From in vitro experiments using [(3)H]alpha-tocopheryl acetate and McARH7777 cells that stably express alpha-tocopherol transfer protein (alpha-TTP), the following results were obtained. First, addition of apolipoprotein A-I (apoA-I), a direct acceptor of the ATP-binding cassette transporter A1 (ABCA1)-secreted lipids, increased alpha-tocopherol secretion in a dose-dependent manner. Second, probucol, an antiatherogenic compound reported to be an inactivator of ABCA1 reduced hepatic alpha-tocopherol secretion. Third, ABCA1-RNAi suppressed hepatic alpha-tocopherol secretion. In a mouse in vivo experiment, addition of 1% probucol to the diet decreased plasma alpha-tocopherol concentrations. These results strongly suggest that ABCA1 is substantially involved in hepatic alpha-tocopherol secretion. Instructions: please extract entity words from the input sentence
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ATP-binding cassette transporter A1 is involved in hepatic alpha-tocopherol secretion. Vitamin E (alpha-tocopherol) is an essential fat-soluble nutrient with antioxidant properties. alpha-Tocopherol transfer protein (alpha-TTP), the product of the gene responsible for familial isolated vitamin E deficiency, plays an important role in maintaining the plasma alpha-tocopherol level by mediating the secretion of alpha-tocopherol by the liver. However, the mechanisms underlying hepatic alpha-tocopherol secretion are not fully understood. This study was undertaken to elucidate the mechanism of alpha-tocopherol re-efflux from hepatocytes, the cells that have the most important role in regulating plasma-alpha-tocopherol concentrations. From in vitro experiments using [(3)H]alpha-tocopheryl acetate and McARH7777 cells that stably express alpha-tocopherol transfer protein (alpha-TTP), the following results were obtained. First, addition of apolipoprotein A-I (apoA-I), a direct acceptor of the ATP-binding cassette transporter A1 (ABCA1)-secreted lipids, increased alpha-tocopherol secretion in a dose-dependent manner. Second, probucol, an antiatherogenic compound reported to be an inactivator of ABCA1 reduced hepatic alpha-tocopherol secretion. Third, ABCA1-RNAi suppressed hepatic alpha-tocopherol secretion. In a mouse in vivo experiment, addition of 1% probucol to the diet decreased plasma alpha-tocopherol concentrations. These results strongly suggest that ABCA1 is substantially involved in hepatic alpha-tocopherol secretion.
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[ "GENE-Y", "CHEMICAL" ]
Histone is a Protein, histones is a Protein, histone is a Protein, histone is a Protein, histones is a Protein, H3 is a Protein, protein phosphatase 1-delta is a Protein, histone is a Protein, histones is a Protein
104_task0
Sentence: Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome segregation defects. Posttranslational modifications of core histones contribute to driving changes in chromatin conformation and compaction. Herein, we investigated the role of histone deacetylation on the mitotic process by inhibiting histone deacetylases shortly before mitosis in human primary fibroblasts. Cells entering mitosis with hyperacetylated histones displayed altered chromatin conformation associated with decreased reactivity to the anti-Ser 10 phospho H3 antibody, increased recruitment of protein phosphatase 1-delta on mitotic chromosomes, and depletion of heterochromatin protein 1 from the centromeric heterochromatin. Inhibition of histone deacetylation before mitosis produced defective chromosome condensation and impaired mitotic progression in living cells, suggesting that improper chromosome condensation may induce mitotic checkpoint activation. In situ hybridization analysis on anaphase cells demonstrated the presence of chromatin bridges, which were caused by persisting cohesion along sister chromatid arms after centromere separation. Thus, the presence of hyperacetylated chromatin during mitosis impairs proper chromosome condensation during the pre-anaphase stages, resulting in poor sister chromatid resolution. Lagging chromosomes consisting of single or paired sisters were also induced by the presence of hyperacetylated histones, indicating that the less constrained centromeric organization associated with heterochromatin protein 1 depletion may promote the attachment of kinetochores to microtubules coming from both poles. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein
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Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome segregation defects. Posttranslational modifications of core histones contribute to driving changes in chromatin conformation and compaction. Herein, we investigated the role of histone deacetylation on the mitotic process by inhibiting histone deacetylases shortly before mitosis in human primary fibroblasts. Cells entering mitosis with hyperacetylated histones displayed altered chromatin conformation associated with decreased reactivity to the anti-Ser 10 phospho H3 antibody, increased recruitment of protein phosphatase 1-delta on mitotic chromosomes, and depletion of heterochromatin protein 1 from the centromeric heterochromatin. Inhibition of histone deacetylation before mitosis produced defective chromosome condensation and impaired mitotic progression in living cells, suggesting that improper chromosome condensation may induce mitotic checkpoint activation. In situ hybridization analysis on anaphase cells demonstrated the presence of chromatin bridges, which were caused by persisting cohesion along sister chromatid arms after centromere separation. Thus, the presence of hyperacetylated chromatin during mitosis impairs proper chromosome condensation during the pre-anaphase stages, resulting in poor sister chromatid resolution. Lagging chromosomes consisting of single or paired sisters were also induced by the presence of hyperacetylated histones, indicating that the less constrained centromeric organization associated with heterochromatin protein 1 depletion may promote the attachment of kinetochores to microtubules coming from both poles.
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[ "Protein" ]
Histone is a Protein, histones is a Protein, histone is a Protein, histone is a Protein, histones is a Protein, H3 is a Protein, protein phosphatase 1-delta is a Protein, histone is a Protein, histones is a Protein
104_task1
Sentence: Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome segregation defects. Posttranslational modifications of core histones contribute to driving changes in chromatin conformation and compaction. Herein, we investigated the role of histone deacetylation on the mitotic process by inhibiting histone deacetylases shortly before mitosis in human primary fibroblasts. Cells entering mitosis with hyperacetylated histones displayed altered chromatin conformation associated with decreased reactivity to the anti-Ser 10 phospho H3 antibody, increased recruitment of protein phosphatase 1-delta on mitotic chromosomes, and depletion of heterochromatin protein 1 from the centromeric heterochromatin. Inhibition of histone deacetylation before mitosis produced defective chromosome condensation and impaired mitotic progression in living cells, suggesting that improper chromosome condensation may induce mitotic checkpoint activation. In situ hybridization analysis on anaphase cells demonstrated the presence of chromatin bridges, which were caused by persisting cohesion along sister chromatid arms after centromere separation. Thus, the presence of hyperacetylated chromatin during mitosis impairs proper chromosome condensation during the pre-anaphase stages, resulting in poor sister chromatid resolution. Lagging chromosomes consisting of single or paired sisters were also induced by the presence of hyperacetylated histones, indicating that the less constrained centromeric organization associated with heterochromatin protein 1 depletion may promote the attachment of kinetochores to microtubules coming from both poles. Instructions: please typing these entity words according to sentence: Histone, histones, histone, histone, histones, H3, protein phosphatase 1-delta, histone, histones Options: Protein
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Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome segregation defects. Posttranslational modifications of core histones contribute to driving changes in chromatin conformation and compaction. Herein, we investigated the role of histone deacetylation on the mitotic process by inhibiting histone deacetylases shortly before mitosis in human primary fibroblasts. Cells entering mitosis with hyperacetylated histones displayed altered chromatin conformation associated with decreased reactivity to the anti-Ser 10 phospho H3 antibody, increased recruitment of protein phosphatase 1-delta on mitotic chromosomes, and depletion of heterochromatin protein 1 from the centromeric heterochromatin. Inhibition of histone deacetylation before mitosis produced defective chromosome condensation and impaired mitotic progression in living cells, suggesting that improper chromosome condensation may induce mitotic checkpoint activation. In situ hybridization analysis on anaphase cells demonstrated the presence of chromatin bridges, which were caused by persisting cohesion along sister chromatid arms after centromere separation. Thus, the presence of hyperacetylated chromatin during mitosis impairs proper chromosome condensation during the pre-anaphase stages, resulting in poor sister chromatid resolution. Lagging chromosomes consisting of single or paired sisters were also induced by the presence of hyperacetylated histones, indicating that the less constrained centromeric organization associated with heterochromatin protein 1 depletion may promote the attachment of kinetochores to microtubules coming from both poles.
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[ "Protein" ]
Histone, histones, histone, histone, histones, H3, protein phosphatase 1-delta, histone, histones
104_task2
Sentence: Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome segregation defects. Posttranslational modifications of core histones contribute to driving changes in chromatin conformation and compaction. Herein, we investigated the role of histone deacetylation on the mitotic process by inhibiting histone deacetylases shortly before mitosis in human primary fibroblasts. Cells entering mitosis with hyperacetylated histones displayed altered chromatin conformation associated with decreased reactivity to the anti-Ser 10 phospho H3 antibody, increased recruitment of protein phosphatase 1-delta on mitotic chromosomes, and depletion of heterochromatin protein 1 from the centromeric heterochromatin. Inhibition of histone deacetylation before mitosis produced defective chromosome condensation and impaired mitotic progression in living cells, suggesting that improper chromosome condensation may induce mitotic checkpoint activation. In situ hybridization analysis on anaphase cells demonstrated the presence of chromatin bridges, which were caused by persisting cohesion along sister chromatid arms after centromere separation. Thus, the presence of hyperacetylated chromatin during mitosis impairs proper chromosome condensation during the pre-anaphase stages, resulting in poor sister chromatid resolution. Lagging chromosomes consisting of single or paired sisters were also induced by the presence of hyperacetylated histones, indicating that the less constrained centromeric organization associated with heterochromatin protein 1 depletion may promote the attachment of kinetochores to microtubules coming from both poles. Instructions: please extract entity words from the input sentence
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Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome segregation defects. Posttranslational modifications of core histones contribute to driving changes in chromatin conformation and compaction. Herein, we investigated the role of histone deacetylation on the mitotic process by inhibiting histone deacetylases shortly before mitosis in human primary fibroblasts. Cells entering mitosis with hyperacetylated histones displayed altered chromatin conformation associated with decreased reactivity to the anti-Ser 10 phospho H3 antibody, increased recruitment of protein phosphatase 1-delta on mitotic chromosomes, and depletion of heterochromatin protein 1 from the centromeric heterochromatin. Inhibition of histone deacetylation before mitosis produced defective chromosome condensation and impaired mitotic progression in living cells, suggesting that improper chromosome condensation may induce mitotic checkpoint activation. In situ hybridization analysis on anaphase cells demonstrated the presence of chromatin bridges, which were caused by persisting cohesion along sister chromatid arms after centromere separation. Thus, the presence of hyperacetylated chromatin during mitosis impairs proper chromosome condensation during the pre-anaphase stages, resulting in poor sister chromatid resolution. Lagging chromosomes consisting of single or paired sisters were also induced by the presence of hyperacetylated histones, indicating that the less constrained centromeric organization associated with heterochromatin protein 1 depletion may promote the attachment of kinetochores to microtubules coming from both poles.
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[ "Protein" ]
Diagnostic imaging is an umlsterm, renal transplantation is an umlsterm, differential diagnosis is an umlsterm, postoperative complications is an umlsterm, color is an umlsterm, imaging is an umlsterm, method is an umlsterm, choice is an umlsterm, diagnosis is an umlsterm, transplant rejection is an umlsterm, MRI is an umlsterm, method is an umlsterm, diagnosis is an umlsterm, transplant is an umlsterm, dysfunction is an umlsterm, diagnosis is an umlsterm, angiography is an umlsterm, urography is an umlsterm, diagnostic is an umlsterm, angiography is an umlsterm, pyelography is an umlsterm, Angiography is an umlsterm, carbon dioxide is an umlsterm, angiography is an umlsterm, gold is an umlsterm, standard is an umlsterm, diagnosis is an umlsterm, transplant is an umlsterm, artery is an umlsterm, stenosis is an umlsterm
DerRadiologe.90390404.eng.abstr_task0
Sentence: Diagnostic imaging after renal transplantation is of high importance in the differential diagnosis of peri-and postoperative complications . Sonography with color duplex imaging is the method of choice in the diagnosis of acute transplant rejection . MRI is an additional method in the diagnosis of transplant dysfunction especially in diagnosis of perirenal fluid collections . MR angiography and MR urography are noninvasive diagnostic modalities with the potential to replace angiography and pyelography . Angiography , complemented by carbon dioxide angiography , still is the gold standard in the diagnosis of transplant artery stenosis . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Diagnostic imaging after renal transplantation is of high importance in the differential diagnosis of peri-and postoperative complications . Sonography with color duplex imaging is the method of choice in the diagnosis of acute transplant rejection . MRI is an additional method in the diagnosis of transplant dysfunction especially in diagnosis of perirenal fluid collections . MR angiography and MR urography are noninvasive diagnostic modalities with the potential to replace angiography and pyelography . Angiography , complemented by carbon dioxide angiography , still is the gold standard in the diagnosis of transplant artery stenosis .
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[ "umlsterm" ]
Diagnostic imaging is an umlsterm, renal transplantation is an umlsterm, differential diagnosis is an umlsterm, postoperative complications is an umlsterm, color is an umlsterm, imaging is an umlsterm, method is an umlsterm, choice is an umlsterm, diagnosis is an umlsterm, transplant rejection is an umlsterm, MRI is an umlsterm, method is an umlsterm, diagnosis is an umlsterm, transplant is an umlsterm, dysfunction is an umlsterm, diagnosis is an umlsterm, angiography is an umlsterm, urography is an umlsterm, diagnostic is an umlsterm, angiography is an umlsterm, pyelography is an umlsterm, Angiography is an umlsterm, carbon dioxide is an umlsterm, angiography is an umlsterm, gold is an umlsterm, standard is an umlsterm, diagnosis is an umlsterm, transplant is an umlsterm, artery is an umlsterm, stenosis is an umlsterm
DerRadiologe.90390404.eng.abstr_task1
Sentence: Diagnostic imaging after renal transplantation is of high importance in the differential diagnosis of peri-and postoperative complications . Sonography with color duplex imaging is the method of choice in the diagnosis of acute transplant rejection . MRI is an additional method in the diagnosis of transplant dysfunction especially in diagnosis of perirenal fluid collections . MR angiography and MR urography are noninvasive diagnostic modalities with the potential to replace angiography and pyelography . Angiography , complemented by carbon dioxide angiography , still is the gold standard in the diagnosis of transplant artery stenosis . Instructions: please typing these entity words according to sentence: Diagnostic imaging, renal transplantation, differential diagnosis, postoperative complications, color, imaging, method, choice, diagnosis, transplant rejection, MRI, method, diagnosis, transplant, dysfunction, diagnosis, angiography, urography, diagnostic, angiography, pyelography, Angiography, carbon dioxide, angiography, gold, standard, diagnosis, transplant, artery, stenosis Options: umlsterm
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Diagnostic imaging after renal transplantation is of high importance in the differential diagnosis of peri-and postoperative complications . Sonography with color duplex imaging is the method of choice in the diagnosis of acute transplant rejection . MRI is an additional method in the diagnosis of transplant dysfunction especially in diagnosis of perirenal fluid collections . MR angiography and MR urography are noninvasive diagnostic modalities with the potential to replace angiography and pyelography . Angiography , complemented by carbon dioxide angiography , still is the gold standard in the diagnosis of transplant artery stenosis .
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[ "umlsterm" ]
Diagnostic imaging, renal transplantation, differential diagnosis, postoperative complications, color, imaging, method, choice, diagnosis, transplant rejection, MRI, method, diagnosis, transplant, dysfunction, diagnosis, angiography, urography, diagnostic, angiography, pyelography, Angiography, carbon dioxide, angiography, gold, standard, diagnosis, transplant, artery, stenosis
DerRadiologe.90390404.eng.abstr_task2
Sentence: Diagnostic imaging after renal transplantation is of high importance in the differential diagnosis of peri-and postoperative complications . Sonography with color duplex imaging is the method of choice in the diagnosis of acute transplant rejection . MRI is an additional method in the diagnosis of transplant dysfunction especially in diagnosis of perirenal fluid collections . MR angiography and MR urography are noninvasive diagnostic modalities with the potential to replace angiography and pyelography . Angiography , complemented by carbon dioxide angiography , still is the gold standard in the diagnosis of transplant artery stenosis . Instructions: please extract entity words from the input sentence
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Diagnostic imaging after renal transplantation is of high importance in the differential diagnosis of peri-and postoperative complications . Sonography with color duplex imaging is the method of choice in the diagnosis of acute transplant rejection . MRI is an additional method in the diagnosis of transplant dysfunction especially in diagnosis of perirenal fluid collections . MR angiography and MR urography are noninvasive diagnostic modalities with the potential to replace angiography and pyelography . Angiography , complemented by carbon dioxide angiography , still is the gold standard in the diagnosis of transplant artery stenosis .
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[ "umlsterm" ]
Patienten is an umlsterm, Anaesthesiologie is an umlsterm, Patienten is an umlsterm, Narkoseaerzte is an umlsterm, Personalaufwand is an umlsterm, Anaesthesieschwester is an umlsterm, Befunderhebung is an umlsterm, Verwendung is an umlsterm, Befunderhebung is an umlsterm, Patientendaten is an umlsterm, Patienten is an umlsterm, Ausbildung is an umlsterm, Anaesthesiologie is an umlsterm
DerAnaesthesist.40430223.ger.abstr_task0
Sentence: Seit nunmehr 15 Jahren werden alle Patienten , die an der chirurgischen Universitaetsklinik in Graz zu elektiven Operationen aufgenommen werden , in der praeoperativen Ambulanz der Universitaetsklinik fuer Anaesthesiologie auf ihre Narkosetauglichkeit untersucht . Von dieser Einrichtung haben bisher mehr als 75 000 Patienten profitiert . Die Vorteile der fachspezifischen Voruntersuchung durch Narkoseaerzte ueberwiegen bei weitem den erforderlichen Personalaufwand von einem Anaesthesisten , einer Anaesthesieschwester und einer Sekretaerin . Die Kosten fuer eine Untersuchung sind mit OeS 160,- nur ein Bruchteil des Gesamtaufwands waehrend des stationaeren Aufenthalts . Durch die Systematisierung des Untersuchungsgangs ist die Befunderhebung zeitsparend und von jungen Kollegen gut nachvollziehbar . Durch die seit 5 Jahren in Verwendung befindliche Befunderhebung mit einem Datenbanksystem wurde der Untersuchungsgang systematisiert und ist daher von jedem jungen Kollegen nach kurzer Einschulung nachvollziehbar . Die Patientendaten sind seither jederzeit abrufbar und sowohl fuer statistische Zwecke als auch fuer selektive Datensuche auswertbar . Diese sowohl fuer den Patienten als auch fuer die Ausbildung aeusserst positive Einrichtung , ist ein fester Bestandteil der Universitaetsklinik fuer Anaesthesiologie in Graz geworden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Seit nunmehr 15 Jahren werden alle Patienten , die an der chirurgischen Universitaetsklinik in Graz zu elektiven Operationen aufgenommen werden , in der praeoperativen Ambulanz der Universitaetsklinik fuer Anaesthesiologie auf ihre Narkosetauglichkeit untersucht . Von dieser Einrichtung haben bisher mehr als 75 000 Patienten profitiert . Die Vorteile der fachspezifischen Voruntersuchung durch Narkoseaerzte ueberwiegen bei weitem den erforderlichen Personalaufwand von einem Anaesthesisten , einer Anaesthesieschwester und einer Sekretaerin . Die Kosten fuer eine Untersuchung sind mit OeS 160,- nur ein Bruchteil des Gesamtaufwands waehrend des stationaeren Aufenthalts . Durch die Systematisierung des Untersuchungsgangs ist die Befunderhebung zeitsparend und von jungen Kollegen gut nachvollziehbar . Durch die seit 5 Jahren in Verwendung befindliche Befunderhebung mit einem Datenbanksystem wurde der Untersuchungsgang systematisiert und ist daher von jedem jungen Kollegen nach kurzer Einschulung nachvollziehbar . Die Patientendaten sind seither jederzeit abrufbar und sowohl fuer statistische Zwecke als auch fuer selektive Datensuche auswertbar . Diese sowohl fuer den Patienten als auch fuer die Ausbildung aeusserst positive Einrichtung , ist ein fester Bestandteil der Universitaetsklinik fuer Anaesthesiologie in Graz geworden .
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[ "umlsterm" ]
Patienten is an umlsterm, Anaesthesiologie is an umlsterm, Patienten is an umlsterm, Narkoseaerzte is an umlsterm, Personalaufwand is an umlsterm, Anaesthesieschwester is an umlsterm, Befunderhebung is an umlsterm, Verwendung is an umlsterm, Befunderhebung is an umlsterm, Patientendaten is an umlsterm, Patienten is an umlsterm, Ausbildung is an umlsterm, Anaesthesiologie is an umlsterm
DerAnaesthesist.40430223.ger.abstr_task1
Sentence: Seit nunmehr 15 Jahren werden alle Patienten , die an der chirurgischen Universitaetsklinik in Graz zu elektiven Operationen aufgenommen werden , in der praeoperativen Ambulanz der Universitaetsklinik fuer Anaesthesiologie auf ihre Narkosetauglichkeit untersucht . Von dieser Einrichtung haben bisher mehr als 75 000 Patienten profitiert . Die Vorteile der fachspezifischen Voruntersuchung durch Narkoseaerzte ueberwiegen bei weitem den erforderlichen Personalaufwand von einem Anaesthesisten , einer Anaesthesieschwester und einer Sekretaerin . Die Kosten fuer eine Untersuchung sind mit OeS 160,- nur ein Bruchteil des Gesamtaufwands waehrend des stationaeren Aufenthalts . Durch die Systematisierung des Untersuchungsgangs ist die Befunderhebung zeitsparend und von jungen Kollegen gut nachvollziehbar . Durch die seit 5 Jahren in Verwendung befindliche Befunderhebung mit einem Datenbanksystem wurde der Untersuchungsgang systematisiert und ist daher von jedem jungen Kollegen nach kurzer Einschulung nachvollziehbar . Die Patientendaten sind seither jederzeit abrufbar und sowohl fuer statistische Zwecke als auch fuer selektive Datensuche auswertbar . Diese sowohl fuer den Patienten als auch fuer die Ausbildung aeusserst positive Einrichtung , ist ein fester Bestandteil der Universitaetsklinik fuer Anaesthesiologie in Graz geworden . Instructions: please typing these entity words according to sentence: Patienten, Anaesthesiologie, Patienten, Narkoseaerzte, Personalaufwand, Anaesthesieschwester, Befunderhebung, Verwendung, Befunderhebung, Patientendaten, Patienten, Ausbildung, Anaesthesiologie Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]
Seit nunmehr 15 Jahren werden alle Patienten , die an der chirurgischen Universitaetsklinik in Graz zu elektiven Operationen aufgenommen werden , in der praeoperativen Ambulanz der Universitaetsklinik fuer Anaesthesiologie auf ihre Narkosetauglichkeit untersucht . Von dieser Einrichtung haben bisher mehr als 75 000 Patienten profitiert . Die Vorteile der fachspezifischen Voruntersuchung durch Narkoseaerzte ueberwiegen bei weitem den erforderlichen Personalaufwand von einem Anaesthesisten , einer Anaesthesieschwester und einer Sekretaerin . Die Kosten fuer eine Untersuchung sind mit OeS 160,- nur ein Bruchteil des Gesamtaufwands waehrend des stationaeren Aufenthalts . Durch die Systematisierung des Untersuchungsgangs ist die Befunderhebung zeitsparend und von jungen Kollegen gut nachvollziehbar . Durch die seit 5 Jahren in Verwendung befindliche Befunderhebung mit einem Datenbanksystem wurde der Untersuchungsgang systematisiert und ist daher von jedem jungen Kollegen nach kurzer Einschulung nachvollziehbar . Die Patientendaten sind seither jederzeit abrufbar und sowohl fuer statistische Zwecke als auch fuer selektive Datensuche auswertbar . Diese sowohl fuer den Patienten als auch fuer die Ausbildung aeusserst positive Einrichtung , ist ein fester Bestandteil der Universitaetsklinik fuer Anaesthesiologie in Graz geworden .
[ "Seit", "nunmehr", "15", "Jahren", "werden", "alle", "Patienten", ",", "die", "an", "der", "chirurgischen", "Universitaetsklinik", "in", "Graz", "zu", "elektiven", "Operationen", "aufgenommen", "werden", ",", "in", "der", "praeoperativen", "Ambulanz", "der", "Universitaetsklinik", "fuer", "Anaesthesiologie", "auf", "ihre", "Narkosetauglichkeit", "untersucht", ".", "Von", "dieser", "Einrichtung", "haben", "bisher", "mehr", "als", "75", "000", "Patienten", "profitiert", ".", "Die", "Vorteile", "der", "fachspezifischen", "Voruntersuchung", "durch", "Narkoseaerzte", "ueberwiegen", "bei", "weitem", "den", "erforderlichen", "Personalaufwand", "von", "einem", "Anaesthesisten", ",", "einer", "Anaesthesieschwester", "und", "einer", "Sekretaerin", ".", "Die", "Kosten", "fuer", "eine", "Untersuchung", "sind", "mit", "OeS", "160,-", "nur", "ein", "Bruchteil", "des", "Gesamtaufwands", "waehrend", "des", "stationaeren", "Aufenthalts", ".", "Durch", "die", "Systematisierung", "des", "Untersuchungsgangs", "ist", "die", "Befunderhebung", "zeitsparend", "und", "von", "jungen", "Kollegen", "gut", "nachvollziehbar", ".", "Durch", "die", "seit", "5", "Jahren", "in", "Verwendung", "befindliche", "Befunderhebung", "mit", "einem", "Datenbanksystem", "wurde", "der", "Untersuchungsgang", "systematisiert", "und", "ist", "daher", "von", "jedem", "jungen", "Kollegen", "nach", "kurzer", "Einschulung", "nachvollziehbar", ".", "Die", "Patientendaten", "sind", "seither", "jederzeit", "abrufbar", "und", "sowohl", "fuer", "statistische", "Zwecke", "als", "auch", "fuer", "selektive", "Datensuche", "auswertbar", ".", "Diese", "sowohl", "fuer", "den", "Patienten", "als", "auch", "fuer", "die", "Ausbildung", "aeusserst", "positive", "Einrichtung", ",", "ist", "ein", "fester", "Bestandteil", "der", "Universitaetsklinik", "fuer", "Anaesthesiologie", "in", "Graz", "geworden", "." ]
[ "umlsterm" ]
Patienten, Anaesthesiologie, Patienten, Narkoseaerzte, Personalaufwand, Anaesthesieschwester, Befunderhebung, Verwendung, Befunderhebung, Patientendaten, Patienten, Ausbildung, Anaesthesiologie
DerAnaesthesist.40430223.ger.abstr_task2
Sentence: Seit nunmehr 15 Jahren werden alle Patienten , die an der chirurgischen Universitaetsklinik in Graz zu elektiven Operationen aufgenommen werden , in der praeoperativen Ambulanz der Universitaetsklinik fuer Anaesthesiologie auf ihre Narkosetauglichkeit untersucht . Von dieser Einrichtung haben bisher mehr als 75 000 Patienten profitiert . Die Vorteile der fachspezifischen Voruntersuchung durch Narkoseaerzte ueberwiegen bei weitem den erforderlichen Personalaufwand von einem Anaesthesisten , einer Anaesthesieschwester und einer Sekretaerin . Die Kosten fuer eine Untersuchung sind mit OeS 160,- nur ein Bruchteil des Gesamtaufwands waehrend des stationaeren Aufenthalts . Durch die Systematisierung des Untersuchungsgangs ist die Befunderhebung zeitsparend und von jungen Kollegen gut nachvollziehbar . Durch die seit 5 Jahren in Verwendung befindliche Befunderhebung mit einem Datenbanksystem wurde der Untersuchungsgang systematisiert und ist daher von jedem jungen Kollegen nach kurzer Einschulung nachvollziehbar . Die Patientendaten sind seither jederzeit abrufbar und sowohl fuer statistische Zwecke als auch fuer selektive Datensuche auswertbar . Diese sowohl fuer den Patienten als auch fuer die Ausbildung aeusserst positive Einrichtung , ist ein fester Bestandteil der Universitaetsklinik fuer Anaesthesiologie in Graz geworden . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]
Seit nunmehr 15 Jahren werden alle Patienten , die an der chirurgischen Universitaetsklinik in Graz zu elektiven Operationen aufgenommen werden , in der praeoperativen Ambulanz der Universitaetsklinik fuer Anaesthesiologie auf ihre Narkosetauglichkeit untersucht . Von dieser Einrichtung haben bisher mehr als 75 000 Patienten profitiert . Die Vorteile der fachspezifischen Voruntersuchung durch Narkoseaerzte ueberwiegen bei weitem den erforderlichen Personalaufwand von einem Anaesthesisten , einer Anaesthesieschwester und einer Sekretaerin . Die Kosten fuer eine Untersuchung sind mit OeS 160,- nur ein Bruchteil des Gesamtaufwands waehrend des stationaeren Aufenthalts . Durch die Systematisierung des Untersuchungsgangs ist die Befunderhebung zeitsparend und von jungen Kollegen gut nachvollziehbar . Durch die seit 5 Jahren in Verwendung befindliche Befunderhebung mit einem Datenbanksystem wurde der Untersuchungsgang systematisiert und ist daher von jedem jungen Kollegen nach kurzer Einschulung nachvollziehbar . Die Patientendaten sind seither jederzeit abrufbar und sowohl fuer statistische Zwecke als auch fuer selektive Datensuche auswertbar . Diese sowohl fuer den Patienten als auch fuer die Ausbildung aeusserst positive Einrichtung , ist ein fester Bestandteil der Universitaetsklinik fuer Anaesthesiologie in Graz geworden .
[ "Seit", "nunmehr", "15", "Jahren", "werden", "alle", "Patienten", ",", "die", "an", "der", "chirurgischen", "Universitaetsklinik", "in", "Graz", "zu", "elektiven", "Operationen", "aufgenommen", "werden", ",", "in", "der", "praeoperativen", "Ambulanz", "der", "Universitaetsklinik", "fuer", "Anaesthesiologie", "auf", "ihre", "Narkosetauglichkeit", "untersucht", ".", "Von", "dieser", "Einrichtung", "haben", "bisher", "mehr", "als", "75", "000", "Patienten", "profitiert", ".", "Die", "Vorteile", "der", "fachspezifischen", "Voruntersuchung", "durch", "Narkoseaerzte", "ueberwiegen", "bei", "weitem", "den", "erforderlichen", "Personalaufwand", "von", "einem", "Anaesthesisten", ",", "einer", "Anaesthesieschwester", "und", "einer", "Sekretaerin", ".", "Die", "Kosten", "fuer", "eine", "Untersuchung", "sind", "mit", "OeS", "160,-", "nur", "ein", "Bruchteil", "des", "Gesamtaufwands", "waehrend", "des", "stationaeren", "Aufenthalts", ".", "Durch", "die", "Systematisierung", "des", "Untersuchungsgangs", "ist", "die", "Befunderhebung", "zeitsparend", "und", "von", "jungen", "Kollegen", "gut", "nachvollziehbar", ".", "Durch", "die", "seit", "5", "Jahren", "in", "Verwendung", "befindliche", "Befunderhebung", "mit", "einem", "Datenbanksystem", "wurde", "der", "Untersuchungsgang", "systematisiert", "und", "ist", "daher", "von", "jedem", "jungen", "Kollegen", "nach", "kurzer", "Einschulung", "nachvollziehbar", ".", "Die", "Patientendaten", "sind", "seither", "jederzeit", "abrufbar", "und", "sowohl", "fuer", "statistische", "Zwecke", "als", "auch", "fuer", "selektive", "Datensuche", "auswertbar", ".", "Diese", "sowohl", "fuer", "den", "Patienten", "als", "auch", "fuer", "die", "Ausbildung", "aeusserst", "positive", "Einrichtung", ",", "ist", "ein", "fester", "Bestandteil", "der", "Universitaetsklinik", "fuer", "Anaesthesiologie", "in", "Graz", "geworden", "." ]
[ "umlsterm" ]
TCL1 oncogene is a DNA_domain_or_region, MTCP1 / c6.1B is a DNA_domain_or_region, non - leukaemic T cells is a cell_type, ataxia telangiectasia patients is a multi_cell
34262_task0
Sentence: Expression of either the TCL1 oncogene, or transcripts from its homologue MTCP1/c6.1B, in leukaemic and non-leukaemic T cells from ataxia telangiectasia patients. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, DNA_domain_or_region, multi_cell
[ "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "B-multi_cell", "I-multi_cell", "I-multi_cell", "O" ]
Expression of either the TCL1 oncogene, or transcripts from its homologue MTCP1/c6.1B, in leukaemic and non-leukaemic T cells from ataxia telangiectasia patients.
[ "Expression", "of", "either", "the", "TCL1", "oncogene", ",", "or", "transcripts", "from", "its", "homologue", "MTCP1", "/", "c6.1B", ",", "in", "leukaemic", "and", "non", "-", "leukaemic", "T", "cells", "from", "ataxia", "telangiectasia", "patients", "." ]
[ "other_name", "multi_cell", "(AND cell_type cell_type)", "DNA_domain_or_region", "protein_molecule", "cell_type", "RNA_molecule", "DNA_molecule", "tissue", "" ]
TCL1 oncogene is a DNA_domain_or_region, MTCP1 / c6.1B is a DNA_domain_or_region, non - leukaemic T cells is a cell_type, ataxia telangiectasia patients is a multi_cell
34262_task1
Sentence: Expression of either the TCL1 oncogene, or transcripts from its homologue MTCP1/c6.1B, in leukaemic and non-leukaemic T cells from ataxia telangiectasia patients. Instructions: please typing these entity words according to sentence: TCL1 oncogene, MTCP1 / c6.1B, non - leukaemic T cells, ataxia telangiectasia patients Options: cell_type, DNA_domain_or_region, multi_cell
[ "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "B-multi_cell", "I-multi_cell", "I-multi_cell", "O" ]
Expression of either the TCL1 oncogene, or transcripts from its homologue MTCP1/c6.1B, in leukaemic and non-leukaemic T cells from ataxia telangiectasia patients.
[ "Expression", "of", "either", "the", "TCL1", "oncogene", ",", "or", "transcripts", "from", "its", "homologue", "MTCP1", "/", "c6.1B", ",", "in", "leukaemic", "and", "non", "-", "leukaemic", "T", "cells", "from", "ataxia", "telangiectasia", "patients", "." ]
[ "other_name", "multi_cell", "(AND cell_type cell_type)", "DNA_domain_or_region", "protein_molecule", "cell_type", "RNA_molecule", "DNA_molecule", "tissue", "" ]
TCL1 oncogene, MTCP1 / c6.1B, non - leukaemic T cells, ataxia telangiectasia patients
34262_task2
Sentence: Expression of either the TCL1 oncogene, or transcripts from its homologue MTCP1/c6.1B, in leukaemic and non-leukaemic T cells from ataxia telangiectasia patients. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "B-multi_cell", "I-multi_cell", "I-multi_cell", "O" ]
Expression of either the TCL1 oncogene, or transcripts from its homologue MTCP1/c6.1B, in leukaemic and non-leukaemic T cells from ataxia telangiectasia patients.
[ "Expression", "of", "either", "the", "TCL1", "oncogene", ",", "or", "transcripts", "from", "its", "homologue", "MTCP1", "/", "c6.1B", ",", "in", "leukaemic", "and", "non", "-", "leukaemic", "T", "cells", "from", "ataxia", "telangiectasia", "patients", "." ]
[ "other_name", "multi_cell", "(AND cell_type cell_type)", "DNA_domain_or_region", "protein_molecule", "cell_type", "RNA_molecule", "DNA_molecule", "tissue", "" ]
hydrogen is a CHEMICAL, RNase A is a GENE-Y
8700871_task0
Sentence: A general two-process model describes the hydrogen exchange behavior of RNase A in unfolding conditions. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL
[ "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "O" ]
A general two-process model describes the hydrogen exchange behavior of RNase A in unfolding conditions.
[ "A", "general", "two", "-", "process", "model", "describes", "the", "hydrogen", "exchange", "behavior", "of", "RNase", "A", "in", "unfolding", "conditions", "." ]
[ "CHEMICAL", "GENE-Y" ]
hydrogen is a CHEMICAL, RNase A is a GENE-Y
8700871_task1
Sentence: A general two-process model describes the hydrogen exchange behavior of RNase A in unfolding conditions. Instructions: please typing these entity words according to sentence: hydrogen, RNase A Options: GENE-Y, CHEMICAL
[ "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "O" ]
A general two-process model describes the hydrogen exchange behavior of RNase A in unfolding conditions.
[ "A", "general", "two", "-", "process", "model", "describes", "the", "hydrogen", "exchange", "behavior", "of", "RNase", "A", "in", "unfolding", "conditions", "." ]
[ "CHEMICAL", "GENE-Y" ]
hydrogen, RNase A
8700871_task2
Sentence: A general two-process model describes the hydrogen exchange behavior of RNase A in unfolding conditions. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "O" ]
A general two-process model describes the hydrogen exchange behavior of RNase A in unfolding conditions.
[ "A", "general", "two", "-", "process", "model", "describes", "the", "hydrogen", "exchange", "behavior", "of", "RNase", "A", "in", "unfolding", "conditions", "." ]
[ "CHEMICAL", "GENE-Y" ]
trivalent poliovirus vaccines is a Intervention_Pharmacological, children two months is a Participant_Age, oral trivalent poliovirus vaccine ( OPV ) is a Intervention_Pharmacological, injectable ( inactivated ) trivalent poliovirus vaccine ( IPV ) is a Intervention_Pharmacological, 439 is a Participant_Sample-size, children at two , four , and six months of age is a Participant_Age, 85 is a Participant_Sample-size, children at 18 and 20 months of age is a Participant_Age, neutralizing antibodies is a Outcome_Physical, percentage of children with detectable antibodies and the reciprocal geometric mean titers is a Outcome_Physical, geometric mean titers against types 2 and 3 is a Outcome_Physical
79590_task0
Sentence: A comparison of the serologic responses to oral and injectable trivalent poliovirus vaccines . United States children two months of age were randomly assigned to two groups that received either the commercially available oral trivalent poliovirus vaccine ( OPV ) or an injectable ( inactivated ) trivalent poliovirus vaccine ( IPV ) with a confirmed minimum D-antigen content of 27 , 3.5 , and 29 units for poliovirus types 1 , 2 , and 3 , respectively . Vaccine was given at two , four , and 18 months of age . Sera obtained from 439 children at two , four , and six months of age and from 85 children at 18 and 20 months of age were examined for neutralizing antibodies . The percentage of children with detectable antibodies and the reciprocal geometric mean titers were similar for both groups at two months of age for antibodies to all three poliovirus types . At 20 months of age , all children but one had detectable antibodies to all three poliovirus types . Significantly higher geometric mean titers against types 2 and 3 were noted at 20 months of age for the IPV group . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Outcome_Physical, Intervention_Pharmacological, Participant_Age, Participant_Sample-size
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "B-Participant_Sample-size", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
A comparison of the serologic responses to oral and injectable trivalent poliovirus vaccines . United States children two months of age were randomly assigned to two groups that received either the commercially available oral trivalent poliovirus vaccine ( OPV ) or an injectable ( inactivated ) trivalent poliovirus vaccine ( IPV ) with a confirmed minimum D-antigen content of 27 , 3.5 , and 29 units for poliovirus types 1 , 2 , and 3 , respectively . Vaccine was given at two , four , and 18 months of age . Sera obtained from 439 children at two , four , and six months of age and from 85 children at 18 and 20 months of age were examined for neutralizing antibodies . The percentage of children with detectable antibodies and the reciprocal geometric mean titers were similar for both groups at two months of age for antibodies to all three poliovirus types . At 20 months of age , all children but one had detectable antibodies to all three poliovirus types . Significantly higher geometric mean titers against types 2 and 3 were noted at 20 months of age for the IPV group .
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[ "Outcome_Physical", "Intervention_Pharmacological", "Participant_Age", "Participant_Sample-size" ]
trivalent poliovirus vaccines is a Intervention_Pharmacological, children two months is a Participant_Age, oral trivalent poliovirus vaccine ( OPV ) is a Intervention_Pharmacological, injectable ( inactivated ) trivalent poliovirus vaccine ( IPV ) is a Intervention_Pharmacological, 439 is a Participant_Sample-size, children at two , four , and six months of age is a Participant_Age, 85 is a Participant_Sample-size, children at 18 and 20 months of age is a Participant_Age, neutralizing antibodies is a Outcome_Physical, percentage of children with detectable antibodies and the reciprocal geometric mean titers is a Outcome_Physical, geometric mean titers against types 2 and 3 is a Outcome_Physical
79590_task1
Sentence: A comparison of the serologic responses to oral and injectable trivalent poliovirus vaccines . United States children two months of age were randomly assigned to two groups that received either the commercially available oral trivalent poliovirus vaccine ( OPV ) or an injectable ( inactivated ) trivalent poliovirus vaccine ( IPV ) with a confirmed minimum D-antigen content of 27 , 3.5 , and 29 units for poliovirus types 1 , 2 , and 3 , respectively . Vaccine was given at two , four , and 18 months of age . Sera obtained from 439 children at two , four , and six months of age and from 85 children at 18 and 20 months of age were examined for neutralizing antibodies . The percentage of children with detectable antibodies and the reciprocal geometric mean titers were similar for both groups at two months of age for antibodies to all three poliovirus types . At 20 months of age , all children but one had detectable antibodies to all three poliovirus types . Significantly higher geometric mean titers against types 2 and 3 were noted at 20 months of age for the IPV group . Instructions: please typing these entity words according to sentence: trivalent poliovirus vaccines, children two months, oral trivalent poliovirus vaccine ( OPV ), injectable ( inactivated ) trivalent poliovirus vaccine ( IPV ), 439, children at two , four , and six months of age, 85, children at 18 and 20 months of age, neutralizing antibodies, percentage of children with detectable antibodies and the reciprocal geometric mean titers, geometric mean titers against types 2 and 3 Options: Outcome_Physical, Intervention_Pharmacological, Participant_Age, Participant_Sample-size
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A comparison of the serologic responses to oral and injectable trivalent poliovirus vaccines . United States children two months of age were randomly assigned to two groups that received either the commercially available oral trivalent poliovirus vaccine ( OPV ) or an injectable ( inactivated ) trivalent poliovirus vaccine ( IPV ) with a confirmed minimum D-antigen content of 27 , 3.5 , and 29 units for poliovirus types 1 , 2 , and 3 , respectively . Vaccine was given at two , four , and 18 months of age . Sera obtained from 439 children at two , four , and six months of age and from 85 children at 18 and 20 months of age were examined for neutralizing antibodies . The percentage of children with detectable antibodies and the reciprocal geometric mean titers were similar for both groups at two months of age for antibodies to all three poliovirus types . At 20 months of age , all children but one had detectable antibodies to all three poliovirus types . Significantly higher geometric mean titers against types 2 and 3 were noted at 20 months of age for the IPV group .
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[ "Outcome_Physical", "Intervention_Pharmacological", "Participant_Age", "Participant_Sample-size" ]
trivalent poliovirus vaccines, children two months, oral trivalent poliovirus vaccine ( OPV ), injectable ( inactivated ) trivalent poliovirus vaccine ( IPV ), 439, children at two , four , and six months of age, 85, children at 18 and 20 months of age, neutralizing antibodies, percentage of children with detectable antibodies and the reciprocal geometric mean titers, geometric mean titers against types 2 and 3
79590_task2
Sentence: A comparison of the serologic responses to oral and injectable trivalent poliovirus vaccines . United States children two months of age were randomly assigned to two groups that received either the commercially available oral trivalent poliovirus vaccine ( OPV ) or an injectable ( inactivated ) trivalent poliovirus vaccine ( IPV ) with a confirmed minimum D-antigen content of 27 , 3.5 , and 29 units for poliovirus types 1 , 2 , and 3 , respectively . Vaccine was given at two , four , and 18 months of age . Sera obtained from 439 children at two , four , and six months of age and from 85 children at 18 and 20 months of age were examined for neutralizing antibodies . The percentage of children with detectable antibodies and the reciprocal geometric mean titers were similar for both groups at two months of age for antibodies to all three poliovirus types . At 20 months of age , all children but one had detectable antibodies to all three poliovirus types . Significantly higher geometric mean titers against types 2 and 3 were noted at 20 months of age for the IPV group . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "B-Participant_Sample-size", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
A comparison of the serologic responses to oral and injectable trivalent poliovirus vaccines . United States children two months of age were randomly assigned to two groups that received either the commercially available oral trivalent poliovirus vaccine ( OPV ) or an injectable ( inactivated ) trivalent poliovirus vaccine ( IPV ) with a confirmed minimum D-antigen content of 27 , 3.5 , and 29 units for poliovirus types 1 , 2 , and 3 , respectively . Vaccine was given at two , four , and 18 months of age . Sera obtained from 439 children at two , four , and six months of age and from 85 children at 18 and 20 months of age were examined for neutralizing antibodies . The percentage of children with detectable antibodies and the reciprocal geometric mean titers were similar for both groups at two months of age for antibodies to all three poliovirus types . At 20 months of age , all children but one had detectable antibodies to all three poliovirus types . Significantly higher geometric mean titers against types 2 and 3 were noted at 20 months of age for the IPV group .
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[ "Outcome_Physical", "Intervention_Pharmacological", "Participant_Age", "Participant_Sample-size" ]
observation is an umlsterm, inpatient is an umlsterm, group psychotherapy is an umlsterm, treatment is an umlsterm, treatment is an umlsterm, development is an umlsterm, methods is an umlsterm
Psychotherapeut.80430018.eng.abstr_task0
Sentence: Based upon the observation that some current approaches of quality assurance do not really come up to the specific characteristics of different psychotherapeutic settings , this article discusses quality assurance from the perspective of inpatient group psychotherapy . It differentiates issues of structural quality ( e.g. the importance of the institutional frame , rules for indication , or treatment concepts ) , process quality with special consideration of problems connected with short term group treatment , and outcome quality , which in order to be assured needs the development of methods which reflect the group setting adequately . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]
Based upon the observation that some current approaches of quality assurance do not really come up to the specific characteristics of different psychotherapeutic settings , this article discusses quality assurance from the perspective of inpatient group psychotherapy . It differentiates issues of structural quality ( e.g. the importance of the institutional frame , rules for indication , or treatment concepts ) , process quality with special consideration of problems connected with short term group treatment , and outcome quality , which in order to be assured needs the development of methods which reflect the group setting adequately .
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[ "umlsterm" ]
observation is an umlsterm, inpatient is an umlsterm, group psychotherapy is an umlsterm, treatment is an umlsterm, treatment is an umlsterm, development is an umlsterm, methods is an umlsterm
Psychotherapeut.80430018.eng.abstr_task1
Sentence: Based upon the observation that some current approaches of quality assurance do not really come up to the specific characteristics of different psychotherapeutic settings , this article discusses quality assurance from the perspective of inpatient group psychotherapy . It differentiates issues of structural quality ( e.g. the importance of the institutional frame , rules for indication , or treatment concepts ) , process quality with special consideration of problems connected with short term group treatment , and outcome quality , which in order to be assured needs the development of methods which reflect the group setting adequately . Instructions: please typing these entity words according to sentence: observation, inpatient, group psychotherapy, treatment, treatment, development, methods Options: umlsterm
[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]
Based upon the observation that some current approaches of quality assurance do not really come up to the specific characteristics of different psychotherapeutic settings , this article discusses quality assurance from the perspective of inpatient group psychotherapy . It differentiates issues of structural quality ( e.g. the importance of the institutional frame , rules for indication , or treatment concepts ) , process quality with special consideration of problems connected with short term group treatment , and outcome quality , which in order to be assured needs the development of methods which reflect the group setting adequately .
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[ "umlsterm" ]
observation, inpatient, group psychotherapy, treatment, treatment, development, methods
Psychotherapeut.80430018.eng.abstr_task2
Sentence: Based upon the observation that some current approaches of quality assurance do not really come up to the specific characteristics of different psychotherapeutic settings , this article discusses quality assurance from the perspective of inpatient group psychotherapy . It differentiates issues of structural quality ( e.g. the importance of the institutional frame , rules for indication , or treatment concepts ) , process quality with special consideration of problems connected with short term group treatment , and outcome quality , which in order to be assured needs the development of methods which reflect the group setting adequately . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]
Based upon the observation that some current approaches of quality assurance do not really come up to the specific characteristics of different psychotherapeutic settings , this article discusses quality assurance from the perspective of inpatient group psychotherapy . It differentiates issues of structural quality ( e.g. the importance of the institutional frame , rules for indication , or treatment concepts ) , process quality with special consideration of problems connected with short term group treatment , and outcome quality , which in order to be assured needs the development of methods which reflect the group setting adequately .
[ "Based", "upon", "the", "observation", "that", "some", "current", "approaches", "of", "quality", "assurance", "do", "not", "really", "come", "up", "to", "the", "specific", "characteristics", "of", "different", "psychotherapeutic", "settings", ",", "this", "article", "discusses", "quality", "assurance", "from", "the", "perspective", "of", "inpatient", "group", "psychotherapy", ".", "It", "differentiates", "issues", "of", "structural", "quality", "(", "e.g", ".", "the", "importance", "of", "the", "institutional", "frame", ",", "rules", "for", "indication", ",", "or", "treatment", "concepts", ")", ",", "process", "quality", "with", "special", "consideration", "of", "problems", "connected", "with", "short", "term", "group", "treatment", ",", "and", "outcome", "quality", ",", "which", "in", "order", "to", "be", "assured", "needs", "the", "development", "of", "methods", "which", "reflect", "the", "group", "setting", "adequately", "." ]
[ "umlsterm" ]
gabapentin is a Intervention_Pharmacological, acute pain is a Outcome_Pain, allodynia is a Outcome_Physical, herpes zoster is a Participant_Condition, placebo - controlled is a Intervention_Control, oral gabapentin is a Intervention_Pharmacological, allodynia associated with herpes zoster is a Outcome_Pain, Pain severity is a Outcome_Pain, allodynia area and severity is a Outcome_Pain, overall pain relief is a Outcome_Pain
23001_task0
Sentence: A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster . This randomized , double-blind , placebo-controlled crossover study measured the effect of a single dose of oral gabapentin ( 900 mg ) on pain and allodynia associated with herpes zoster . Pain severity decreased by 66 % with gabapentin compared to 33 % with placebo . Reductions in allodynia area and severity , and overall pain relief , were also greater with gabapentin . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Control, Participant_Condition, Outcome_Physical, Outcome_Pain
[ "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "B-Outcome_Pain", "I-Outcome_Pain", "O", "B-Outcome_Physical", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "B-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "O", "O", "O", "O" ]
A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster . This randomized , double-blind , placebo-controlled crossover study measured the effect of a single dose of oral gabapentin ( 900 mg ) on pain and allodynia associated with herpes zoster . Pain severity decreased by 66 % with gabapentin compared to 33 % with placebo . Reductions in allodynia area and severity , and overall pain relief , were also greater with gabapentin .
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[ "Outcome_Pain", "Intervention_Control", "Intervention_Pharmacological", "Participant_Condition", "Outcome_Physical" ]
gabapentin is a Intervention_Pharmacological, acute pain is a Outcome_Pain, allodynia is a Outcome_Physical, herpes zoster is a Participant_Condition, placebo - controlled is a Intervention_Control, oral gabapentin is a Intervention_Pharmacological, allodynia associated with herpes zoster is a Outcome_Pain, Pain severity is a Outcome_Pain, allodynia area and severity is a Outcome_Pain, overall pain relief is a Outcome_Pain
23001_task1
Sentence: A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster . This randomized , double-blind , placebo-controlled crossover study measured the effect of a single dose of oral gabapentin ( 900 mg ) on pain and allodynia associated with herpes zoster . Pain severity decreased by 66 % with gabapentin compared to 33 % with placebo . Reductions in allodynia area and severity , and overall pain relief , were also greater with gabapentin . Instructions: please typing these entity words according to sentence: gabapentin, acute pain, allodynia, herpes zoster, placebo - controlled, oral gabapentin, allodynia associated with herpes zoster, Pain severity, allodynia area and severity, overall pain relief Options: Intervention_Pharmacological, Intervention_Control, Participant_Condition, Outcome_Physical, Outcome_Pain
[ "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "B-Outcome_Pain", "I-Outcome_Pain", "O", "B-Outcome_Physical", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "B-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "O", "O", "O", "O" ]
A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster . This randomized , double-blind , placebo-controlled crossover study measured the effect of a single dose of oral gabapentin ( 900 mg ) on pain and allodynia associated with herpes zoster . Pain severity decreased by 66 % with gabapentin compared to 33 % with placebo . Reductions in allodynia area and severity , and overall pain relief , were also greater with gabapentin .
[ "A", "single", "dose", "of", "gabapentin", "reduces", "acute", "pain", "and", "allodynia", "in", "patients", "with", "herpes", "zoster", ".", "This", "randomized", ",", "double", "-", "blind", ",", "placebo", "-", "controlled", "crossover", "study", "measured", "the", "effect", "of", "a", "single", "dose", "of", "oral", "gabapentin", "(", "900", "mg", ")", "on", "pain", "and", "allodynia", "associated", "with", "herpes", "zoster", ".", "Pain", "severity", "decreased", "by", "66", "%", "with", "gabapentin", "compared", "to", "33", "%", "with", "placebo", ".", "Reductions", "in", "allodynia", "area", "and", "severity", ",", "and", "overall", "pain", "relief", ",", "were", "also", "greater", "with", "gabapentin", "." ]
[ "Outcome_Pain", "Intervention_Control", "Intervention_Pharmacological", "Participant_Condition", "Outcome_Physical" ]
gabapentin, acute pain, allodynia, herpes zoster, placebo - controlled, oral gabapentin, allodynia associated with herpes zoster, Pain severity, allodynia area and severity, overall pain relief
23001_task2
Sentence: A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster . This randomized , double-blind , placebo-controlled crossover study measured the effect of a single dose of oral gabapentin ( 900 mg ) on pain and allodynia associated with herpes zoster . Pain severity decreased by 66 % with gabapentin compared to 33 % with placebo . Reductions in allodynia area and severity , and overall pain relief , were also greater with gabapentin . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "B-Outcome_Pain", "I-Outcome_Pain", "O", "B-Outcome_Physical", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "B-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "O", "O", "O", "O" ]
A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster . This randomized , double-blind , placebo-controlled crossover study measured the effect of a single dose of oral gabapentin ( 900 mg ) on pain and allodynia associated with herpes zoster . Pain severity decreased by 66 % with gabapentin compared to 33 % with placebo . Reductions in allodynia area and severity , and overall pain relief , were also greater with gabapentin .
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[ "Outcome_Pain", "Intervention_Control", "Intervention_Pharmacological", "Participant_Condition", "Outcome_Physical" ]
interleukin-8 is a Protein, Interleukin-8 is a Protein, IL-8 is a Protein, IL-8 is a Protein, IL-8 is a Protein, IL-8 is a Protein, MEK1 is a Protein, IL-8 is a Protein
344_task0
Sentence: Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins. Interleukin-8 (IL-8) is a chemokine that belongs to the alpha-chemokine or CXC subfamily and is produced by a wide variety of human cells, including monocytes and polymorphonuclear cells (PMN). IL-8 is secreted in response to inflammatory stimuli, notably bacterial products such as lipopolysaccharide (LPS), but little is known about the mechanisms by which these agents mediate IL-8 induction. In this report, we show that Mycoplasma fermentans lipid-associated membrane proteins (LAMPf) induce the production of high levels of IL-8 by THP-1 (human monocyte) cells and PMN at the same extent as LPS. It was previously demonstrated that stimulation of monocytic cells with either LPS or LAMPf led to a series of common downstream signaling events, including the activation of protein tyrosine kinase and of mitogen-activated protein kinase cascades. By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins. Interleukin-8 (IL-8) is a chemokine that belongs to the alpha-chemokine or CXC subfamily and is produced by a wide variety of human cells, including monocytes and polymorphonuclear cells (PMN). IL-8 is secreted in response to inflammatory stimuli, notably bacterial products such as lipopolysaccharide (LPS), but little is known about the mechanisms by which these agents mediate IL-8 induction. In this report, we show that Mycoplasma fermentans lipid-associated membrane proteins (LAMPf) induce the production of high levels of IL-8 by THP-1 (human monocyte) cells and PMN at the same extent as LPS. It was previously demonstrated that stimulation of monocytic cells with either LPS or LAMPf led to a series of common downstream signaling events, including the activation of protein tyrosine kinase and of mitogen-activated protein kinase cascades. By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions.
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[ "Protein" ]
interleukin-8 is a Protein, Interleukin-8 is a Protein, IL-8 is a Protein, IL-8 is a Protein, IL-8 is a Protein, IL-8 is a Protein, MEK1 is a Protein, IL-8 is a Protein
344_task1
Sentence: Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins. Interleukin-8 (IL-8) is a chemokine that belongs to the alpha-chemokine or CXC subfamily and is produced by a wide variety of human cells, including monocytes and polymorphonuclear cells (PMN). IL-8 is secreted in response to inflammatory stimuli, notably bacterial products such as lipopolysaccharide (LPS), but little is known about the mechanisms by which these agents mediate IL-8 induction. In this report, we show that Mycoplasma fermentans lipid-associated membrane proteins (LAMPf) induce the production of high levels of IL-8 by THP-1 (human monocyte) cells and PMN at the same extent as LPS. It was previously demonstrated that stimulation of monocytic cells with either LPS or LAMPf led to a series of common downstream signaling events, including the activation of protein tyrosine kinase and of mitogen-activated protein kinase cascades. By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions. Instructions: please typing these entity words according to sentence: interleukin-8, Interleukin-8, IL-8, IL-8, IL-8, IL-8, MEK1, IL-8 Options: Protein
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Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins. Interleukin-8 (IL-8) is a chemokine that belongs to the alpha-chemokine or CXC subfamily and is produced by a wide variety of human cells, including monocytes and polymorphonuclear cells (PMN). IL-8 is secreted in response to inflammatory stimuli, notably bacterial products such as lipopolysaccharide (LPS), but little is known about the mechanisms by which these agents mediate IL-8 induction. In this report, we show that Mycoplasma fermentans lipid-associated membrane proteins (LAMPf) induce the production of high levels of IL-8 by THP-1 (human monocyte) cells and PMN at the same extent as LPS. It was previously demonstrated that stimulation of monocytic cells with either LPS or LAMPf led to a series of common downstream signaling events, including the activation of protein tyrosine kinase and of mitogen-activated protein kinase cascades. By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions.
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[ "Protein" ]
interleukin-8, Interleukin-8, IL-8, IL-8, IL-8, IL-8, MEK1, IL-8
344_task2
Sentence: Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins. Interleukin-8 (IL-8) is a chemokine that belongs to the alpha-chemokine or CXC subfamily and is produced by a wide variety of human cells, including monocytes and polymorphonuclear cells (PMN). IL-8 is secreted in response to inflammatory stimuli, notably bacterial products such as lipopolysaccharide (LPS), but little is known about the mechanisms by which these agents mediate IL-8 induction. In this report, we show that Mycoplasma fermentans lipid-associated membrane proteins (LAMPf) induce the production of high levels of IL-8 by THP-1 (human monocyte) cells and PMN at the same extent as LPS. It was previously demonstrated that stimulation of monocytic cells with either LPS or LAMPf led to a series of common downstream signaling events, including the activation of protein tyrosine kinase and of mitogen-activated protein kinase cascades. By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions. Instructions: please extract entity words from the input sentence
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Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins. Interleukin-8 (IL-8) is a chemokine that belongs to the alpha-chemokine or CXC subfamily and is produced by a wide variety of human cells, including monocytes and polymorphonuclear cells (PMN). IL-8 is secreted in response to inflammatory stimuli, notably bacterial products such as lipopolysaccharide (LPS), but little is known about the mechanisms by which these agents mediate IL-8 induction. In this report, we show that Mycoplasma fermentans lipid-associated membrane proteins (LAMPf) induce the production of high levels of IL-8 by THP-1 (human monocyte) cells and PMN at the same extent as LPS. It was previously demonstrated that stimulation of monocytic cells with either LPS or LAMPf led to a series of common downstream signaling events, including the activation of protein tyrosine kinase and of mitogen-activated protein kinase cascades. By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions.
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[ "Protein" ]
histone is a Protein, Tat is a Protein, histone is a Protein, histone is a Protein, Tat is a Protein, Tat is a Protein, Tat is a Protein, Tat is a Protein, lysines 50 is a Entity, 51 is a Entity, p300 is a Protein, CBP is a Protein, lysines is a Entity, p300 is a Protein, CBP is a Protein, Tat is a Protein, Tat is a Protein, lysines 50 is a Entity, 51 is a Entity, Tat is a Protein, histone is a Protein, GCN5 is a Protein, p300 is a Protein, CBP is a Protein, Tat is a Protein
45_task0
Sentence: The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat. Factor acetyltransferase activity associated with several histone acetyltransferases plays a key role in the control of transcription. Here we report that hGCN5, a well known histone acetyltransferase, specifically interacts with and acetylates the human immunodeficiency virus type 1 (HIV-1) transactivator protein, Tat. The interaction between Tat and hGCN5 is direct and involves the acetyltransferase and the bromodomain regions of hGCN5, as well as a limited region of Tat encompassing the cysteine-rich domain of the protein. Tat lysines 50 and 51, target of acetylation by p300/CBP, were also found to be acetylated by hGCN5. The acetylation of these two lysines by p300/CBP has been recently shown to stimulate Tat transcriptional activity and accordingly, we have found that hGCN5 can considerably enhance Tat-dependent transcription of the HIV-1 long terminal repeat. These data highlight the importance of the acetylation of lysines 50 and 51 in the function of Tat, since different histone acetyltransferases involved in distinct signaling pathways, GCN5 and p300/CBP, converge to acetylate Tat on the same site. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein
[ "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "B-Entity", "I-Entity", "O", "B-Entity", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "B-Entity", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O" ]
The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat. Factor acetyltransferase activity associated with several histone acetyltransferases plays a key role in the control of transcription. Here we report that hGCN5, a well known histone acetyltransferase, specifically interacts with and acetylates the human immunodeficiency virus type 1 (HIV-1) transactivator protein, Tat. The interaction between Tat and hGCN5 is direct and involves the acetyltransferase and the bromodomain regions of hGCN5, as well as a limited region of Tat encompassing the cysteine-rich domain of the protein. Tat lysines 50 and 51, target of acetylation by p300/CBP, were also found to be acetylated by hGCN5. The acetylation of these two lysines by p300/CBP has been recently shown to stimulate Tat transcriptional activity and accordingly, we have found that hGCN5 can considerably enhance Tat-dependent transcription of the HIV-1 long terminal repeat. These data highlight the importance of the acetylation of lysines 50 and 51 in the function of Tat, since different histone acetyltransferases involved in distinct signaling pathways, GCN5 and p300/CBP, converge to acetylate Tat on the same site.
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[ "Entity", "Protein" ]
histone is a Protein, Tat is a Protein, histone is a Protein, histone is a Protein, Tat is a Protein, Tat is a Protein, Tat is a Protein, Tat is a Protein, lysines 50 is a Entity, 51 is a Entity, p300 is a Protein, CBP is a Protein, lysines is a Entity, p300 is a Protein, CBP is a Protein, Tat is a Protein, Tat is a Protein, lysines 50 is a Entity, 51 is a Entity, Tat is a Protein, histone is a Protein, GCN5 is a Protein, p300 is a Protein, CBP is a Protein, Tat is a Protein
45_task1
Sentence: The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat. Factor acetyltransferase activity associated with several histone acetyltransferases plays a key role in the control of transcription. Here we report that hGCN5, a well known histone acetyltransferase, specifically interacts with and acetylates the human immunodeficiency virus type 1 (HIV-1) transactivator protein, Tat. The interaction between Tat and hGCN5 is direct and involves the acetyltransferase and the bromodomain regions of hGCN5, as well as a limited region of Tat encompassing the cysteine-rich domain of the protein. Tat lysines 50 and 51, target of acetylation by p300/CBP, were also found to be acetylated by hGCN5. The acetylation of these two lysines by p300/CBP has been recently shown to stimulate Tat transcriptional activity and accordingly, we have found that hGCN5 can considerably enhance Tat-dependent transcription of the HIV-1 long terminal repeat. These data highlight the importance of the acetylation of lysines 50 and 51 in the function of Tat, since different histone acetyltransferases involved in distinct signaling pathways, GCN5 and p300/CBP, converge to acetylate Tat on the same site. Instructions: please typing these entity words according to sentence: histone, Tat, histone, histone, Tat, Tat, Tat, Tat, lysines 50, 51, p300, CBP, lysines, p300, CBP, Tat, Tat, lysines 50, 51, Tat, histone, GCN5, p300, CBP, Tat Options: Entity, Protein
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The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat. Factor acetyltransferase activity associated with several histone acetyltransferases plays a key role in the control of transcription. Here we report that hGCN5, a well known histone acetyltransferase, specifically interacts with and acetylates the human immunodeficiency virus type 1 (HIV-1) transactivator protein, Tat. The interaction between Tat and hGCN5 is direct and involves the acetyltransferase and the bromodomain regions of hGCN5, as well as a limited region of Tat encompassing the cysteine-rich domain of the protein. Tat lysines 50 and 51, target of acetylation by p300/CBP, were also found to be acetylated by hGCN5. The acetylation of these two lysines by p300/CBP has been recently shown to stimulate Tat transcriptional activity and accordingly, we have found that hGCN5 can considerably enhance Tat-dependent transcription of the HIV-1 long terminal repeat. These data highlight the importance of the acetylation of lysines 50 and 51 in the function of Tat, since different histone acetyltransferases involved in distinct signaling pathways, GCN5 and p300/CBP, converge to acetylate Tat on the same site.
[ "The", "histone", "acetyltransferase", ",", "hGCN5", ",", "interacts", "with", "and", "acetylates", "the", "HIV", "transactivator", ",", "Tat", ".", "\n", "Factor", "acetyltransferase", "activity", "associated", "with", "several", "histone", "acetyltransferases", "plays", "a", "key", "role", "in", "the", "control", "of", "transcription", ".", "Here", "we", "report", "that", "hGCN5", ",", "a", "well", "known", "histone", "acetyltransferase", ",", "specifically", "interacts", "with", "and", "acetylates", "the", "human", "immunodeficiency", "virus", "type", "1", "(", "HIV-1", ")", "transactivator", "protein", ",", "Tat", ".", "The", "interaction", "between", "Tat", "and", "hGCN5", "is", "direct", "and", "involves", "the", "acetyltransferase", "and", "the", "bromodomain", "regions", "of", "hGCN5", ",", "as", "well", "as", "a", "limited", "region", "of", "Tat", "encompassing", "the", "cysteine", "-", "rich", "domain", "of", "the", "protein", ".", "Tat", "lysines", "50", "and", "51", ",", "target", "of", "acetylation", "by", "p300", "/", "CBP", ",", "were", "also", "found", "to", "be", "acetylated", "by", "hGCN5", ".", "The", "acetylation", "of", "these", "two", "lysines", "by", "p300", "/", "CBP", "has", "been", "recently", "shown", "to", "stimulate", "Tat", "transcriptional", "activity", "and", "accordingly", ",", "we", "have", "found", "that", "hGCN5", "can", "considerably", "enhance", "Tat", "-", "dependent", "transcription", "of", "the", "HIV-1", "long", "terminal", "repeat", ".", "These", "data", "highlight", "the", "importance", "of", "the", "acetylation", "of", "lysines", "50", "and", "51", "in", "the", "function", "of", "Tat", ",", "since", "different", "histone", "acetyltransferases", "involved", "in", "distinct", "signaling", "pathways", ",", "GCN5", "and", "p300", "/", "CBP", ",", "converge", "to", "acetylate", "Tat", "on", "the", "same", "site", ".", "\n" ]
[ "Entity", "Protein" ]
histone, Tat, histone, histone, Tat, Tat, Tat, Tat, lysines 50, 51, p300, CBP, lysines, p300, CBP, Tat, Tat, lysines 50, 51, Tat, histone, GCN5, p300, CBP, Tat
45_task2
Sentence: The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat. Factor acetyltransferase activity associated with several histone acetyltransferases plays a key role in the control of transcription. Here we report that hGCN5, a well known histone acetyltransferase, specifically interacts with and acetylates the human immunodeficiency virus type 1 (HIV-1) transactivator protein, Tat. The interaction between Tat and hGCN5 is direct and involves the acetyltransferase and the bromodomain regions of hGCN5, as well as a limited region of Tat encompassing the cysteine-rich domain of the protein. Tat lysines 50 and 51, target of acetylation by p300/CBP, were also found to be acetylated by hGCN5. The acetylation of these two lysines by p300/CBP has been recently shown to stimulate Tat transcriptional activity and accordingly, we have found that hGCN5 can considerably enhance Tat-dependent transcription of the HIV-1 long terminal repeat. These data highlight the importance of the acetylation of lysines 50 and 51 in the function of Tat, since different histone acetyltransferases involved in distinct signaling pathways, GCN5 and p300/CBP, converge to acetylate Tat on the same site. Instructions: please extract entity words from the input sentence
[ "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "B-Entity", "I-Entity", "O", "B-Entity", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "B-Entity", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O" ]
The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat. Factor acetyltransferase activity associated with several histone acetyltransferases plays a key role in the control of transcription. Here we report that hGCN5, a well known histone acetyltransferase, specifically interacts with and acetylates the human immunodeficiency virus type 1 (HIV-1) transactivator protein, Tat. The interaction between Tat and hGCN5 is direct and involves the acetyltransferase and the bromodomain regions of hGCN5, as well as a limited region of Tat encompassing the cysteine-rich domain of the protein. Tat lysines 50 and 51, target of acetylation by p300/CBP, were also found to be acetylated by hGCN5. The acetylation of these two lysines by p300/CBP has been recently shown to stimulate Tat transcriptional activity and accordingly, we have found that hGCN5 can considerably enhance Tat-dependent transcription of the HIV-1 long terminal repeat. These data highlight the importance of the acetylation of lysines 50 and 51 in the function of Tat, since different histone acetyltransferases involved in distinct signaling pathways, GCN5 and p300/CBP, converge to acetylate Tat on the same site.
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[ "Entity", "Protein" ]
gastric carcinoma is a Disease, garlic is a Plant, gastric cancer is a Disease, garlic is a Plant, tumour is a Disease, garlic is a Plant, garlic is a Plant, garlic is a Plant, garlic is a Plant, cancer is a Disease, garlic is a Plant, garlic is a Plant, cancer is a Disease
8439494_task0
Sentence: Recently published results of epidemiologic case-control studies in China and Italy on gastric carcinoma in relation to diet suggest that consuming garlic may reduce the risk of gastric cancer. Chemical constituents of garlic have been tested for their inhibiting effect on carcinogenesis, using in vitro and in vivo models. In most experiments inhibition of tumour growth was established using fresh garlic extract, garlic compounds or synthetically prepared analogs. In this review the strengths and weaknesses of the experiments are discussed and the outcomes are evaluated to assess the possible significance of garlic or garlic compounds for the prevention of cancer in humans. It is concluded that evidence from laboratory experiments and epidemiologic studies is presently not conclusive as to the preventive activity of garlic. However, the available evidence warrants further research into the possible role of garlic in the prevention of cancer in humans. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Disease, Plant
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "B-Plant", "O", "O", "O", "O", "O", "B-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "B-Disease", "O", "O", "O" ]
Recently published results of epidemiologic case-control studies in China and Italy on gastric carcinoma in relation to diet suggest that consuming garlic may reduce the risk of gastric cancer. Chemical constituents of garlic have been tested for their inhibiting effect on carcinogenesis, using in vitro and in vivo models. In most experiments inhibition of tumour growth was established using fresh garlic extract, garlic compounds or synthetically prepared analogs. In this review the strengths and weaknesses of the experiments are discussed and the outcomes are evaluated to assess the possible significance of garlic or garlic compounds for the prevention of cancer in humans. It is concluded that evidence from laboratory experiments and epidemiologic studies is presently not conclusive as to the preventive activity of garlic. However, the available evidence warrants further research into the possible role of garlic in the prevention of cancer in humans.
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[ "Disease", "Plant" ]
gastric carcinoma is a Disease, garlic is a Plant, gastric cancer is a Disease, garlic is a Plant, tumour is a Disease, garlic is a Plant, garlic is a Plant, garlic is a Plant, garlic is a Plant, cancer is a Disease, garlic is a Plant, garlic is a Plant, cancer is a Disease
8439494_task1
Sentence: Recently published results of epidemiologic case-control studies in China and Italy on gastric carcinoma in relation to diet suggest that consuming garlic may reduce the risk of gastric cancer. Chemical constituents of garlic have been tested for their inhibiting effect on carcinogenesis, using in vitro and in vivo models. In most experiments inhibition of tumour growth was established using fresh garlic extract, garlic compounds or synthetically prepared analogs. In this review the strengths and weaknesses of the experiments are discussed and the outcomes are evaluated to assess the possible significance of garlic or garlic compounds for the prevention of cancer in humans. It is concluded that evidence from laboratory experiments and epidemiologic studies is presently not conclusive as to the preventive activity of garlic. However, the available evidence warrants further research into the possible role of garlic in the prevention of cancer in humans. Instructions: please typing these entity words according to sentence: gastric carcinoma, garlic, gastric cancer, garlic, tumour, garlic, garlic, garlic, garlic, cancer, garlic, garlic, cancer Options: Disease, Plant
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "B-Plant", "O", "O", "O", "O", "O", "B-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "B-Disease", "O", "O", "O" ]
Recently published results of epidemiologic case-control studies in China and Italy on gastric carcinoma in relation to diet suggest that consuming garlic may reduce the risk of gastric cancer. Chemical constituents of garlic have been tested for their inhibiting effect on carcinogenesis, using in vitro and in vivo models. In most experiments inhibition of tumour growth was established using fresh garlic extract, garlic compounds or synthetically prepared analogs. In this review the strengths and weaknesses of the experiments are discussed and the outcomes are evaluated to assess the possible significance of garlic or garlic compounds for the prevention of cancer in humans. It is concluded that evidence from laboratory experiments and epidemiologic studies is presently not conclusive as to the preventive activity of garlic. However, the available evidence warrants further research into the possible role of garlic in the prevention of cancer in humans.
[ "Recently", "published", "results", "of", "epidemiologic", "case", "-", "control", "studies", "in", "China", "and", "Italy", "on", "gastric", "carcinoma", "in", "relation", "to", "diet", "suggest", "that", "consuming", "garlic", "may", "reduce", "the", "risk", "of", "gastric", "cancer", ".", "Chemical", "constituents", "of", "garlic", "have", "been", "tested", "for", "their", "inhibiting", "effect", "on", "carcinogenesis", ",", "using", "in", "vitro", "and", "in", "vivo", "models", ".", "In", "most", "experiments", "inhibition", "of", "tumour", "growth", "was", "established", "using", "fresh", "garlic", "extract", ",", "garlic", "compounds", "or", "synthetically", "prepared", "analogs", ".", "In", "this", "review", "the", "strengths", "and", "weaknesses", "of", "the", "experiments", "are", "discussed", "and", "the", "outcomes", "are", "evaluated", "to", "assess", "the", "possible", "significance", "of", "garlic", "or", "garlic", "compounds", "for", "the", "prevention", "of", "cancer", "in", "humans", ".", "It", "is", "concluded", "that", "evidence", "from", "laboratory", "experiments", "and", "epidemiologic", "studies", "is", "presently", "not", "conclusive", "as", "to", "the", "preventive", "activity", "of", "garlic", ".", "However", ",", "the", "available", "evidence", "warrants", "further", "research", "into", "the", "possible", "role", "of", "garlic", "in", "the", "prevention", "of", "cancer", "in", "humans", "." ]
[ "Disease", "Plant" ]
gastric carcinoma, garlic, gastric cancer, garlic, tumour, garlic, garlic, garlic, garlic, cancer, garlic, garlic, cancer
8439494_task2
Sentence: Recently published results of epidemiologic case-control studies in China and Italy on gastric carcinoma in relation to diet suggest that consuming garlic may reduce the risk of gastric cancer. Chemical constituents of garlic have been tested for their inhibiting effect on carcinogenesis, using in vitro and in vivo models. In most experiments inhibition of tumour growth was established using fresh garlic extract, garlic compounds or synthetically prepared analogs. In this review the strengths and weaknesses of the experiments are discussed and the outcomes are evaluated to assess the possible significance of garlic or garlic compounds for the prevention of cancer in humans. It is concluded that evidence from laboratory experiments and epidemiologic studies is presently not conclusive as to the preventive activity of garlic. However, the available evidence warrants further research into the possible role of garlic in the prevention of cancer in humans. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "B-Disease", "I-Disease", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "B-Plant", "O", "O", "O", "O", "O", "B-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "B-Disease", "O", "O", "O" ]
Recently published results of epidemiologic case-control studies in China and Italy on gastric carcinoma in relation to diet suggest that consuming garlic may reduce the risk of gastric cancer. Chemical constituents of garlic have been tested for their inhibiting effect on carcinogenesis, using in vitro and in vivo models. In most experiments inhibition of tumour growth was established using fresh garlic extract, garlic compounds or synthetically prepared analogs. In this review the strengths and weaknesses of the experiments are discussed and the outcomes are evaluated to assess the possible significance of garlic or garlic compounds for the prevention of cancer in humans. It is concluded that evidence from laboratory experiments and epidemiologic studies is presently not conclusive as to the preventive activity of garlic. However, the available evidence warrants further research into the possible role of garlic in the prevention of cancer in humans.
[ "Recently", "published", "results", "of", "epidemiologic", "case", "-", "control", "studies", "in", "China", "and", "Italy", "on", "gastric", "carcinoma", "in", "relation", "to", "diet", "suggest", "that", "consuming", "garlic", "may", "reduce", "the", "risk", "of", "gastric", "cancer", ".", "Chemical", "constituents", "of", "garlic", "have", "been", "tested", "for", "their", "inhibiting", "effect", "on", "carcinogenesis", ",", "using", "in", "vitro", "and", "in", "vivo", "models", ".", "In", "most", "experiments", "inhibition", "of", "tumour", "growth", "was", "established", "using", "fresh", "garlic", "extract", ",", "garlic", "compounds", "or", "synthetically", "prepared", "analogs", ".", "In", "this", "review", "the", "strengths", "and", "weaknesses", "of", "the", "experiments", "are", "discussed", "and", "the", "outcomes", "are", "evaluated", "to", "assess", "the", "possible", "significance", "of", "garlic", "or", "garlic", "compounds", "for", "the", "prevention", "of", "cancer", "in", "humans", ".", "It", "is", "concluded", "that", "evidence", "from", "laboratory", "experiments", "and", "epidemiologic", "studies", "is", "presently", "not", "conclusive", "as", "to", "the", "preventive", "activity", "of", "garlic", ".", "However", ",", "the", "available", "evidence", "warrants", "further", "research", "into", "the", "possible", "role", "of", "garlic", "in", "the", "prevention", "of", "cancer", "in", "humans", "." ]
[ "Disease", "Plant" ]
herpes simplex virus type 2 tegument proteins is a protein_family_or_group, CD4 T cells is a cell_type, human genital herpes lesions is a tissue
79324_task0
Sentence: Recognition of herpes simplex virus type 2 tegument proteins by CD4 T cells infiltrating human genital herpes lesions. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, protein_family_or_group, tissue
[ "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O", "B-tissue", "I-tissue", "I-tissue", "I-tissue", "O" ]
Recognition of herpes simplex virus type 2 tegument proteins by CD4 T cells infiltrating human genital herpes lesions.
[ "Recognition", "of", "herpes", "simplex", "virus", "type", "2", "tegument", "proteins", "by", "CD4", "T", "cells", "infiltrating", "human", "genital", "herpes", "lesions", "." ]
[ "protein_family_or_group", "cell_line", "cell_type", "other_name", "tissue", "virus", "(AND other_name other_name)", "(AND DNA_domain_or_region DNA_domain_or_region)", "", "protein_domain_or_region", "multi_cell", "DNA_family_or_group", "protein_molecule", "DNA_domain_or_region" ]
herpes simplex virus type 2 tegument proteins is a protein_family_or_group, CD4 T cells is a cell_type, human genital herpes lesions is a tissue
79324_task1
Sentence: Recognition of herpes simplex virus type 2 tegument proteins by CD4 T cells infiltrating human genital herpes lesions. Instructions: please typing these entity words according to sentence: herpes simplex virus type 2 tegument proteins, CD4 T cells, human genital herpes lesions Options: cell_type, protein_family_or_group, tissue
[ "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O", "B-tissue", "I-tissue", "I-tissue", "I-tissue", "O" ]
Recognition of herpes simplex virus type 2 tegument proteins by CD4 T cells infiltrating human genital herpes lesions.
[ "Recognition", "of", "herpes", "simplex", "virus", "type", "2", "tegument", "proteins", "by", "CD4", "T", "cells", "infiltrating", "human", "genital", "herpes", "lesions", "." ]
[ "protein_family_or_group", "cell_line", "cell_type", "other_name", "tissue", "virus", "(AND other_name other_name)", "(AND DNA_domain_or_region DNA_domain_or_region)", "", "protein_domain_or_region", "multi_cell", "DNA_family_or_group", "protein_molecule", "DNA_domain_or_region" ]
herpes simplex virus type 2 tegument proteins, CD4 T cells, human genital herpes lesions
79324_task2
Sentence: Recognition of herpes simplex virus type 2 tegument proteins by CD4 T cells infiltrating human genital herpes lesions. Instructions: please extract entity words from the input sentence
[ "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O", "B-tissue", "I-tissue", "I-tissue", "I-tissue", "O" ]
Recognition of herpes simplex virus type 2 tegument proteins by CD4 T cells infiltrating human genital herpes lesions.
[ "Recognition", "of", "herpes", "simplex", "virus", "type", "2", "tegument", "proteins", "by", "CD4", "T", "cells", "infiltrating", "human", "genital", "herpes", "lesions", "." ]
[ "protein_family_or_group", "cell_line", "cell_type", "other_name", "tissue", "virus", "(AND other_name other_name)", "(AND DNA_domain_or_region DNA_domain_or_region)", "", "protein_domain_or_region", "multi_cell", "DNA_family_or_group", "protein_molecule", "DNA_domain_or_region" ]
placebo is a Intervention_Control, piracetam is a Intervention_Pharmacological, risperidone is a Intervention_Pharmacological, autistic disorder is a Participant_Condition, autism is a Participant_Condition, efficacy is a Outcome_Other, 40 is a Participant_Sample-size, children is a Participant_Age, three and 11 years is a Participant_Age, Aberrant Behavior Checklist - Community ( ABC - C ) Rating Scale is a Outcome_Other, ( total score ) is a Outcome_Physical, ABC - C Rating Scale scores is a Outcome_Other, scores in the ABC - C Rating Scale is a Outcome_Other
32850_task0
Sentence: A double-blind placebo controlled trial of piracetam added to risperidone in patients with autistic disorder . It has been reported that autism is a hypoglutamatergic disorder . Therefore , it was of interest to assess the efficacy of piracetam , a positive modulator of AMPA-sensitive glutamate receptors in autistic disorder . About 40 children between the ages three and 11 years ( inclusive ) with a DSM IV clinical diagnosis of autism and who were outpatients from a specialty clinic for children were recruited . The children presented with a chief complaint of severely disruptive symptoms related to autistic disorder . Patients were randomly allocated to piracetam + risperidone ( Group A ) or placebo + risperidone ( Group B ) for a 10-week , double-blind , placebo-controlled study . The dose of risperidone was titrated up to 2 mg/day for children between 10 and 40 kg and 3 mg/day for children weighting above 40 kg . The dose of piracetam was titrated up to 800 mg/day . Patients were assessed at baseline and after 2 , 4 , 6 , 8 and 10 weeks of starting medication . The measure of the outcome was the Aberrant Behavior Checklist-Community ( ABC-C ) Rating Scale ( total score ) . The ABC-C Rating Scale scores improved with piracetam . The difference between the two protocols was significant as indicated by the effect of group , the between subjects factor ( F = 5.85 , d.f . = 1 , P = 0.02 ) . The changes at the endpoint compared with baseline were : -11.90 +/- 3.79 ( mean +/- SD ) and -5.15 +/- 3.04 for group A and B respectively . A significant difference was observed on the change in scores in the ABC-C Rating Scale in week 10 compared with baseline in the two groups ( t = 6.017 , d.f . = 38 , P < 0.0001 ) . The results suggest that a combination of atypical antipsychotic medications and a glutamate agent such as piracetam , might have increase synergistic effects in the treatment of autism . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Participant_Condition, Intervention_Control, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other
[ "O", "O", "O", "O", "B-Intervention_Control", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Age", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
A double-blind placebo controlled trial of piracetam added to risperidone in patients with autistic disorder . It has been reported that autism is a hypoglutamatergic disorder . Therefore , it was of interest to assess the efficacy of piracetam , a positive modulator of AMPA-sensitive glutamate receptors in autistic disorder . About 40 children between the ages three and 11 years ( inclusive ) with a DSM IV clinical diagnosis of autism and who were outpatients from a specialty clinic for children were recruited . The children presented with a chief complaint of severely disruptive symptoms related to autistic disorder . Patients were randomly allocated to piracetam + risperidone ( Group A ) or placebo + risperidone ( Group B ) for a 10-week , double-blind , placebo-controlled study . The dose of risperidone was titrated up to 2 mg/day for children between 10 and 40 kg and 3 mg/day for children weighting above 40 kg . The dose of piracetam was titrated up to 800 mg/day . Patients were assessed at baseline and after 2 , 4 , 6 , 8 and 10 weeks of starting medication . The measure of the outcome was the Aberrant Behavior Checklist-Community ( ABC-C ) Rating Scale ( total score ) . The ABC-C Rating Scale scores improved with piracetam . The difference between the two protocols was significant as indicated by the effect of group , the between subjects factor ( F = 5.85 , d.f . = 1 , P = 0.02 ) . The changes at the endpoint compared with baseline were : -11.90 +/- 3.79 ( mean +/- SD ) and -5.15 +/- 3.04 for group A and B respectively . A significant difference was observed on the change in scores in the ABC-C Rating Scale in week 10 compared with baseline in the two groups ( t = 6.017 , d.f . = 38 , P < 0.0001 ) . The results suggest that a combination of atypical antipsychotic medications and a glutamate agent such as piracetam , might have increase synergistic effects in the treatment of autism .
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[ "Outcome_Other", "Participant_Age", "Participant_Condition", "Outcome_Physical", "Intervention_Pharmacological", "Intervention_Control", "Participant_Sample-size" ]
placebo is a Intervention_Control, piracetam is a Intervention_Pharmacological, risperidone is a Intervention_Pharmacological, autistic disorder is a Participant_Condition, autism is a Participant_Condition, efficacy is a Outcome_Other, 40 is a Participant_Sample-size, children is a Participant_Age, three and 11 years is a Participant_Age, Aberrant Behavior Checklist - Community ( ABC - C ) Rating Scale is a Outcome_Other, ( total score ) is a Outcome_Physical, ABC - C Rating Scale scores is a Outcome_Other, scores in the ABC - C Rating Scale is a Outcome_Other
32850_task1
Sentence: A double-blind placebo controlled trial of piracetam added to risperidone in patients with autistic disorder . It has been reported that autism is a hypoglutamatergic disorder . Therefore , it was of interest to assess the efficacy of piracetam , a positive modulator of AMPA-sensitive glutamate receptors in autistic disorder . About 40 children between the ages three and 11 years ( inclusive ) with a DSM IV clinical diagnosis of autism and who were outpatients from a specialty clinic for children were recruited . The children presented with a chief complaint of severely disruptive symptoms related to autistic disorder . Patients were randomly allocated to piracetam + risperidone ( Group A ) or placebo + risperidone ( Group B ) for a 10-week , double-blind , placebo-controlled study . The dose of risperidone was titrated up to 2 mg/day for children between 10 and 40 kg and 3 mg/day for children weighting above 40 kg . The dose of piracetam was titrated up to 800 mg/day . Patients were assessed at baseline and after 2 , 4 , 6 , 8 and 10 weeks of starting medication . The measure of the outcome was the Aberrant Behavior Checklist-Community ( ABC-C ) Rating Scale ( total score ) . The ABC-C Rating Scale scores improved with piracetam . The difference between the two protocols was significant as indicated by the effect of group , the between subjects factor ( F = 5.85 , d.f . = 1 , P = 0.02 ) . The changes at the endpoint compared with baseline were : -11.90 +/- 3.79 ( mean +/- SD ) and -5.15 +/- 3.04 for group A and B respectively . A significant difference was observed on the change in scores in the ABC-C Rating Scale in week 10 compared with baseline in the two groups ( t = 6.017 , d.f . = 38 , P < 0.0001 ) . The results suggest that a combination of atypical antipsychotic medications and a glutamate agent such as piracetam , might have increase synergistic effects in the treatment of autism . Instructions: please typing these entity words according to sentence: placebo, piracetam, risperidone, autistic disorder, autism, efficacy, 40, children, three and 11 years, Aberrant Behavior Checklist - Community ( ABC - C ) Rating Scale, ( total score ), ABC - C Rating Scale scores, scores in the ABC - C Rating Scale Options: Intervention_Pharmacological, Participant_Condition, Intervention_Control, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other
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A double-blind placebo controlled trial of piracetam added to risperidone in patients with autistic disorder . It has been reported that autism is a hypoglutamatergic disorder . Therefore , it was of interest to assess the efficacy of piracetam , a positive modulator of AMPA-sensitive glutamate receptors in autistic disorder . About 40 children between the ages three and 11 years ( inclusive ) with a DSM IV clinical diagnosis of autism and who were outpatients from a specialty clinic for children were recruited . The children presented with a chief complaint of severely disruptive symptoms related to autistic disorder . Patients were randomly allocated to piracetam + risperidone ( Group A ) or placebo + risperidone ( Group B ) for a 10-week , double-blind , placebo-controlled study . The dose of risperidone was titrated up to 2 mg/day for children between 10 and 40 kg and 3 mg/day for children weighting above 40 kg . The dose of piracetam was titrated up to 800 mg/day . Patients were assessed at baseline and after 2 , 4 , 6 , 8 and 10 weeks of starting medication . The measure of the outcome was the Aberrant Behavior Checklist-Community ( ABC-C ) Rating Scale ( total score ) . The ABC-C Rating Scale scores improved with piracetam . The difference between the two protocols was significant as indicated by the effect of group , the between subjects factor ( F = 5.85 , d.f . = 1 , P = 0.02 ) . The changes at the endpoint compared with baseline were : -11.90 +/- 3.79 ( mean +/- SD ) and -5.15 +/- 3.04 for group A and B respectively . A significant difference was observed on the change in scores in the ABC-C Rating Scale in week 10 compared with baseline in the two groups ( t = 6.017 , d.f . = 38 , P < 0.0001 ) . The results suggest that a combination of atypical antipsychotic medications and a glutamate agent such as piracetam , might have increase synergistic effects in the treatment of autism .
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[ "Outcome_Other", "Participant_Age", "Participant_Condition", "Outcome_Physical", "Intervention_Pharmacological", "Intervention_Control", "Participant_Sample-size" ]
placebo, piracetam, risperidone, autistic disorder, autism, efficacy, 40, children, three and 11 years, Aberrant Behavior Checklist - Community ( ABC - C ) Rating Scale, ( total score ), ABC - C Rating Scale scores, scores in the ABC - C Rating Scale
32850_task2
Sentence: A double-blind placebo controlled trial of piracetam added to risperidone in patients with autistic disorder . It has been reported that autism is a hypoglutamatergic disorder . Therefore , it was of interest to assess the efficacy of piracetam , a positive modulator of AMPA-sensitive glutamate receptors in autistic disorder . About 40 children between the ages three and 11 years ( inclusive ) with a DSM IV clinical diagnosis of autism and who were outpatients from a specialty clinic for children were recruited . The children presented with a chief complaint of severely disruptive symptoms related to autistic disorder . Patients were randomly allocated to piracetam + risperidone ( Group A ) or placebo + risperidone ( Group B ) for a 10-week , double-blind , placebo-controlled study . The dose of risperidone was titrated up to 2 mg/day for children between 10 and 40 kg and 3 mg/day for children weighting above 40 kg . The dose of piracetam was titrated up to 800 mg/day . Patients were assessed at baseline and after 2 , 4 , 6 , 8 and 10 weeks of starting medication . The measure of the outcome was the Aberrant Behavior Checklist-Community ( ABC-C ) Rating Scale ( total score ) . The ABC-C Rating Scale scores improved with piracetam . The difference between the two protocols was significant as indicated by the effect of group , the between subjects factor ( F = 5.85 , d.f . = 1 , P = 0.02 ) . The changes at the endpoint compared with baseline were : -11.90 +/- 3.79 ( mean +/- SD ) and -5.15 +/- 3.04 for group A and B respectively . A significant difference was observed on the change in scores in the ABC-C Rating Scale in week 10 compared with baseline in the two groups ( t = 6.017 , d.f . = 38 , P < 0.0001 ) . The results suggest that a combination of atypical antipsychotic medications and a glutamate agent such as piracetam , might have increase synergistic effects in the treatment of autism . Instructions: please extract entity words from the input sentence
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A double-blind placebo controlled trial of piracetam added to risperidone in patients with autistic disorder . It has been reported that autism is a hypoglutamatergic disorder . Therefore , it was of interest to assess the efficacy of piracetam , a positive modulator of AMPA-sensitive glutamate receptors in autistic disorder . About 40 children between the ages three and 11 years ( inclusive ) with a DSM IV clinical diagnosis of autism and who were outpatients from a specialty clinic for children were recruited . The children presented with a chief complaint of severely disruptive symptoms related to autistic disorder . Patients were randomly allocated to piracetam + risperidone ( Group A ) or placebo + risperidone ( Group B ) for a 10-week , double-blind , placebo-controlled study . The dose of risperidone was titrated up to 2 mg/day for children between 10 and 40 kg and 3 mg/day for children weighting above 40 kg . The dose of piracetam was titrated up to 800 mg/day . Patients were assessed at baseline and after 2 , 4 , 6 , 8 and 10 weeks of starting medication . The measure of the outcome was the Aberrant Behavior Checklist-Community ( ABC-C ) Rating Scale ( total score ) . The ABC-C Rating Scale scores improved with piracetam . The difference between the two protocols was significant as indicated by the effect of group , the between subjects factor ( F = 5.85 , d.f . = 1 , P = 0.02 ) . The changes at the endpoint compared with baseline were : -11.90 +/- 3.79 ( mean +/- SD ) and -5.15 +/- 3.04 for group A and B respectively . A significant difference was observed on the change in scores in the ABC-C Rating Scale in week 10 compared with baseline in the two groups ( t = 6.017 , d.f . = 38 , P < 0.0001 ) . The results suggest that a combination of atypical antipsychotic medications and a glutamate agent such as piracetam , might have increase synergistic effects in the treatment of autism .
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[ "Outcome_Other", "Participant_Age", "Participant_Condition", "Outcome_Physical", "Intervention_Pharmacological", "Intervention_Control", "Participant_Sample-size" ]
fatigue is a Outcome_Physical, children is a Participant_Age, adults is a Participant_Age, young children is a Participant_Age, adolescents and adults is a Participant_Age, chronic fatigue syndrome / myalgic encephalomyelitis ( CFS / ME ) is a Participant_Condition, pain is a Outcome_Pain, anxiety is a Outcome_Mental, multinomial regression is a Intervention_Other, younger ( aged < 12 years ) is a Participant_Age, older ( aged 12 - 18 years ) children is a Participant_Age, Younger children is a Participant_Age, Adults is a Participant_Age, disability is a Outcome_Physical, cognitive symptoms is a Outcome_Mental, headaches is a Outcome_Physical, lymph nodes , palpitations , dizziness , general malaise is a Outcome_Physical, comorbid depression is a Outcome_Mental
72822_task0
Sentence: Chronic fatigue syndrome ( CFS ) or myalgic encephalomyelitis ( ME ) is different in children compared to in adults : a study of UK and Dutch clinical cohorts . OBJECTIVE To investigate differences between young children , adolescents and adults with chronic fatigue syndrome/myalgic encephalomyelitis ( CFS/ME ) . STUDY DESIGN Comparison of clinical cohorts from 8 paediatric and 27 adult CFS/ME services in the UK and a paediatric randomised controlled trial from the Netherlands . Outcome measures include : fatigue ( the UK-Chalder Fatigue Scale ) ; Disability ( the UK-SF-36 physical function subscale ; the Netherlands-CHQ-CF87 ) ; school attendance , pain , anxiety and depression ( the UK-Hospital Anxiety & Depression Scale , Spence Children 's Anxiety Scale ; the Netherlands-Spielberger State-Trait Anxiety Inventory for Children , Children 's Depression Inventory ) ; symptoms ; time-to-assessment ; and body mass index . We used multinomial regression to compare younger ( aged < 12 years ) and older ( aged 12-18 years ) children with adults , and logistic regression to compare UK and Dutch adolescents . RESULTS Younger children had a more equal gender balance compared to adolescents and adults . Adults had more disability and fatigue , and had been ill for longer . Younger children were less likely to have cognitive symptoms ( OR 0.18 ( 95 % CI 0.13 to 0.25 ) ) and more likely to present with a sore throat ( OR 1.42 ( 1.07 to 1.90 ) . Adolescents were more likely to have headaches ( 81.1 % , OR 1.56 ( 1.36 % to 1.80 % ) ) and less likely to have tender lymph nodes , palpitations , dizziness , general malaise and pain , compared to adults . Adolescents were more likely to have comorbid depression ( OR 1.51 ( 1.33 to 1.72 ) ) and less likely to have anxiety ( OR 0.46 ( 0.41 to 0.53 ) ) compared to adults . CONCLUSIONS Paediatricians need to recognise that children with CFS/ME present differently from adults . Whether these differences reflect an underlying aetiopathology requires further investigation . TRIAL REGISTRATION NUMBERS FITNET trial registration numbers are ISRCTN59878666 and NCT00893438 . This paper includes secondary ( post-results ) analysis of data from this trial , but are unrelated to trial outcomes . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Participant_Condition, Intervention_Other, Outcome_Pain, Participant_Age, Outcome_Physical, Outcome_Mental
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Chronic fatigue syndrome ( CFS ) or myalgic encephalomyelitis ( ME ) is different in children compared to in adults : a study of UK and Dutch clinical cohorts . OBJECTIVE To investigate differences between young children , adolescents and adults with chronic fatigue syndrome/myalgic encephalomyelitis ( CFS/ME ) . STUDY DESIGN Comparison of clinical cohorts from 8 paediatric and 27 adult CFS/ME services in the UK and a paediatric randomised controlled trial from the Netherlands . Outcome measures include : fatigue ( the UK-Chalder Fatigue Scale ) ; Disability ( the UK-SF-36 physical function subscale ; the Netherlands-CHQ-CF87 ) ; school attendance , pain , anxiety and depression ( the UK-Hospital Anxiety & Depression Scale , Spence Children 's Anxiety Scale ; the Netherlands-Spielberger State-Trait Anxiety Inventory for Children , Children 's Depression Inventory ) ; symptoms ; time-to-assessment ; and body mass index . We used multinomial regression to compare younger ( aged < 12 years ) and older ( aged 12-18 years ) children with adults , and logistic regression to compare UK and Dutch adolescents . RESULTS Younger children had a more equal gender balance compared to adolescents and adults . Adults had more disability and fatigue , and had been ill for longer . Younger children were less likely to have cognitive symptoms ( OR 0.18 ( 95 % CI 0.13 to 0.25 ) ) and more likely to present with a sore throat ( OR 1.42 ( 1.07 to 1.90 ) . Adolescents were more likely to have headaches ( 81.1 % , OR 1.56 ( 1.36 % to 1.80 % ) ) and less likely to have tender lymph nodes , palpitations , dizziness , general malaise and pain , compared to adults . Adolescents were more likely to have comorbid depression ( OR 1.51 ( 1.33 to 1.72 ) ) and less likely to have anxiety ( OR 0.46 ( 0.41 to 0.53 ) ) compared to adults . CONCLUSIONS Paediatricians need to recognise that children with CFS/ME present differently from adults . Whether these differences reflect an underlying aetiopathology requires further investigation . TRIAL REGISTRATION NUMBERS FITNET trial registration numbers are ISRCTN59878666 and NCT00893438 . This paper includes secondary ( post-results ) analysis of data from this trial , but are unrelated to trial outcomes .
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[ "Participant_Condition", "Outcome_Physical", "Participant_Age", "Intervention_Other", "Outcome_Mental", "Outcome_Pain" ]
fatigue is a Outcome_Physical, children is a Participant_Age, adults is a Participant_Age, young children is a Participant_Age, adolescents and adults is a Participant_Age, chronic fatigue syndrome / myalgic encephalomyelitis ( CFS / ME ) is a Participant_Condition, pain is a Outcome_Pain, anxiety is a Outcome_Mental, multinomial regression is a Intervention_Other, younger ( aged < 12 years ) is a Participant_Age, older ( aged 12 - 18 years ) children is a Participant_Age, Younger children is a Participant_Age, Adults is a Participant_Age, disability is a Outcome_Physical, cognitive symptoms is a Outcome_Mental, headaches is a Outcome_Physical, lymph nodes , palpitations , dizziness , general malaise is a Outcome_Physical, comorbid depression is a Outcome_Mental
72822_task1
Sentence: Chronic fatigue syndrome ( CFS ) or myalgic encephalomyelitis ( ME ) is different in children compared to in adults : a study of UK and Dutch clinical cohorts . OBJECTIVE To investigate differences between young children , adolescents and adults with chronic fatigue syndrome/myalgic encephalomyelitis ( CFS/ME ) . STUDY DESIGN Comparison of clinical cohorts from 8 paediatric and 27 adult CFS/ME services in the UK and a paediatric randomised controlled trial from the Netherlands . Outcome measures include : fatigue ( the UK-Chalder Fatigue Scale ) ; Disability ( the UK-SF-36 physical function subscale ; the Netherlands-CHQ-CF87 ) ; school attendance , pain , anxiety and depression ( the UK-Hospital Anxiety & Depression Scale , Spence Children 's Anxiety Scale ; the Netherlands-Spielberger State-Trait Anxiety Inventory for Children , Children 's Depression Inventory ) ; symptoms ; time-to-assessment ; and body mass index . We used multinomial regression to compare younger ( aged < 12 years ) and older ( aged 12-18 years ) children with adults , and logistic regression to compare UK and Dutch adolescents . RESULTS Younger children had a more equal gender balance compared to adolescents and adults . Adults had more disability and fatigue , and had been ill for longer . Younger children were less likely to have cognitive symptoms ( OR 0.18 ( 95 % CI 0.13 to 0.25 ) ) and more likely to present with a sore throat ( OR 1.42 ( 1.07 to 1.90 ) . Adolescents were more likely to have headaches ( 81.1 % , OR 1.56 ( 1.36 % to 1.80 % ) ) and less likely to have tender lymph nodes , palpitations , dizziness , general malaise and pain , compared to adults . Adolescents were more likely to have comorbid depression ( OR 1.51 ( 1.33 to 1.72 ) ) and less likely to have anxiety ( OR 0.46 ( 0.41 to 0.53 ) ) compared to adults . CONCLUSIONS Paediatricians need to recognise that children with CFS/ME present differently from adults . Whether these differences reflect an underlying aetiopathology requires further investigation . TRIAL REGISTRATION NUMBERS FITNET trial registration numbers are ISRCTN59878666 and NCT00893438 . This paper includes secondary ( post-results ) analysis of data from this trial , but are unrelated to trial outcomes . Instructions: please typing these entity words according to sentence: fatigue, children, adults, young children, adolescents and adults, chronic fatigue syndrome / myalgic encephalomyelitis ( CFS / ME ), pain, anxiety, multinomial regression, younger ( aged < 12 years ), older ( aged 12 - 18 years ) children, Younger children, Adults, disability, cognitive symptoms, headaches, lymph nodes , palpitations , dizziness , general malaise, comorbid depression Options: Participant_Condition, Intervention_Other, Outcome_Pain, Participant_Age, Outcome_Physical, Outcome_Mental
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Chronic fatigue syndrome ( CFS ) or myalgic encephalomyelitis ( ME ) is different in children compared to in adults : a study of UK and Dutch clinical cohorts . OBJECTIVE To investigate differences between young children , adolescents and adults with chronic fatigue syndrome/myalgic encephalomyelitis ( CFS/ME ) . STUDY DESIGN Comparison of clinical cohorts from 8 paediatric and 27 adult CFS/ME services in the UK and a paediatric randomised controlled trial from the Netherlands . Outcome measures include : fatigue ( the UK-Chalder Fatigue Scale ) ; Disability ( the UK-SF-36 physical function subscale ; the Netherlands-CHQ-CF87 ) ; school attendance , pain , anxiety and depression ( the UK-Hospital Anxiety & Depression Scale , Spence Children 's Anxiety Scale ; the Netherlands-Spielberger State-Trait Anxiety Inventory for Children , Children 's Depression Inventory ) ; symptoms ; time-to-assessment ; and body mass index . We used multinomial regression to compare younger ( aged < 12 years ) and older ( aged 12-18 years ) children with adults , and logistic regression to compare UK and Dutch adolescents . RESULTS Younger children had a more equal gender balance compared to adolescents and adults . Adults had more disability and fatigue , and had been ill for longer . Younger children were less likely to have cognitive symptoms ( OR 0.18 ( 95 % CI 0.13 to 0.25 ) ) and more likely to present with a sore throat ( OR 1.42 ( 1.07 to 1.90 ) . Adolescents were more likely to have headaches ( 81.1 % , OR 1.56 ( 1.36 % to 1.80 % ) ) and less likely to have tender lymph nodes , palpitations , dizziness , general malaise and pain , compared to adults . Adolescents were more likely to have comorbid depression ( OR 1.51 ( 1.33 to 1.72 ) ) and less likely to have anxiety ( OR 0.46 ( 0.41 to 0.53 ) ) compared to adults . CONCLUSIONS Paediatricians need to recognise that children with CFS/ME present differently from adults . Whether these differences reflect an underlying aetiopathology requires further investigation . TRIAL REGISTRATION NUMBERS FITNET trial registration numbers are ISRCTN59878666 and NCT00893438 . This paper includes secondary ( post-results ) analysis of data from this trial , but are unrelated to trial outcomes .
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[ "Participant_Condition", "Outcome_Physical", "Participant_Age", "Intervention_Other", "Outcome_Mental", "Outcome_Pain" ]
fatigue, children, adults, young children, adolescents and adults, chronic fatigue syndrome / myalgic encephalomyelitis ( CFS / ME ), pain, anxiety, multinomial regression, younger ( aged < 12 years ), older ( aged 12 - 18 years ) children, Younger children, Adults, disability, cognitive symptoms, headaches, lymph nodes , palpitations , dizziness , general malaise, comorbid depression
72822_task2
Sentence: Chronic fatigue syndrome ( CFS ) or myalgic encephalomyelitis ( ME ) is different in children compared to in adults : a study of UK and Dutch clinical cohorts . OBJECTIVE To investigate differences between young children , adolescents and adults with chronic fatigue syndrome/myalgic encephalomyelitis ( CFS/ME ) . STUDY DESIGN Comparison of clinical cohorts from 8 paediatric and 27 adult CFS/ME services in the UK and a paediatric randomised controlled trial from the Netherlands . Outcome measures include : fatigue ( the UK-Chalder Fatigue Scale ) ; Disability ( the UK-SF-36 physical function subscale ; the Netherlands-CHQ-CF87 ) ; school attendance , pain , anxiety and depression ( the UK-Hospital Anxiety & Depression Scale , Spence Children 's Anxiety Scale ; the Netherlands-Spielberger State-Trait Anxiety Inventory for Children , Children 's Depression Inventory ) ; symptoms ; time-to-assessment ; and body mass index . We used multinomial regression to compare younger ( aged < 12 years ) and older ( aged 12-18 years ) children with adults , and logistic regression to compare UK and Dutch adolescents . RESULTS Younger children had a more equal gender balance compared to adolescents and adults . Adults had more disability and fatigue , and had been ill for longer . Younger children were less likely to have cognitive symptoms ( OR 0.18 ( 95 % CI 0.13 to 0.25 ) ) and more likely to present with a sore throat ( OR 1.42 ( 1.07 to 1.90 ) . Adolescents were more likely to have headaches ( 81.1 % , OR 1.56 ( 1.36 % to 1.80 % ) ) and less likely to have tender lymph nodes , palpitations , dizziness , general malaise and pain , compared to adults . Adolescents were more likely to have comorbid depression ( OR 1.51 ( 1.33 to 1.72 ) ) and less likely to have anxiety ( OR 0.46 ( 0.41 to 0.53 ) ) compared to adults . CONCLUSIONS Paediatricians need to recognise that children with CFS/ME present differently from adults . Whether these differences reflect an underlying aetiopathology requires further investigation . TRIAL REGISTRATION NUMBERS FITNET trial registration numbers are ISRCTN59878666 and NCT00893438 . This paper includes secondary ( post-results ) analysis of data from this trial , but are unrelated to trial outcomes . Instructions: please extract entity words from the input sentence
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Chronic fatigue syndrome ( CFS ) or myalgic encephalomyelitis ( ME ) is different in children compared to in adults : a study of UK and Dutch clinical cohorts . OBJECTIVE To investigate differences between young children , adolescents and adults with chronic fatigue syndrome/myalgic encephalomyelitis ( CFS/ME ) . STUDY DESIGN Comparison of clinical cohorts from 8 paediatric and 27 adult CFS/ME services in the UK and a paediatric randomised controlled trial from the Netherlands . Outcome measures include : fatigue ( the UK-Chalder Fatigue Scale ) ; Disability ( the UK-SF-36 physical function subscale ; the Netherlands-CHQ-CF87 ) ; school attendance , pain , anxiety and depression ( the UK-Hospital Anxiety & Depression Scale , Spence Children 's Anxiety Scale ; the Netherlands-Spielberger State-Trait Anxiety Inventory for Children , Children 's Depression Inventory ) ; symptoms ; time-to-assessment ; and body mass index . We used multinomial regression to compare younger ( aged < 12 years ) and older ( aged 12-18 years ) children with adults , and logistic regression to compare UK and Dutch adolescents . RESULTS Younger children had a more equal gender balance compared to adolescents and adults . Adults had more disability and fatigue , and had been ill for longer . Younger children were less likely to have cognitive symptoms ( OR 0.18 ( 95 % CI 0.13 to 0.25 ) ) and more likely to present with a sore throat ( OR 1.42 ( 1.07 to 1.90 ) . Adolescents were more likely to have headaches ( 81.1 % , OR 1.56 ( 1.36 % to 1.80 % ) ) and less likely to have tender lymph nodes , palpitations , dizziness , general malaise and pain , compared to adults . Adolescents were more likely to have comorbid depression ( OR 1.51 ( 1.33 to 1.72 ) ) and less likely to have anxiety ( OR 0.46 ( 0.41 to 0.53 ) ) compared to adults . CONCLUSIONS Paediatricians need to recognise that children with CFS/ME present differently from adults . Whether these differences reflect an underlying aetiopathology requires further investigation . TRIAL REGISTRATION NUMBERS FITNET trial registration numbers are ISRCTN59878666 and NCT00893438 . This paper includes secondary ( post-results ) analysis of data from this trial , but are unrelated to trial outcomes .
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[ "Participant_Condition", "Outcome_Physical", "Participant_Age", "Intervention_Other", "Outcome_Mental", "Outcome_Pain" ]
Mundschleimhautlaesionen is an umlsterm, Assoziation is an umlsterm, Psoriasis is an umlsterm, Schleimhautlaesionen is an umlsterm, orale Manifestation is an umlsterm, Psoriasis is an umlsterm, Patienten is an umlsterm, Psoriasis is an umlsterm, Zungenschleimhaut is an umlsterm, Histologie is an umlsterm, Schleimhaut is an umlsterm, Parakeratose is an umlsterm, Psoriasis is an umlsterm, Haut is an umlsterm, Patienten is an umlsterm, Therapie is an umlsterm, Haut- is an umlsterm, Schleimhautlaesionen is an umlsterm, Lingua geographica is an umlsterm, orale Manifestation is an umlsterm, Psoriasis is an umlsterm
DerHautarzt.80490850.ger.abstr_task0
Sentence: Mundschleimhautlaesionen sind wiederholt in Assoziation mit Psoriasis beschrieben worden , insbesondere mit der pustuloesen Form . Ob diese Schleimhautlaesionen als orale Manifestation einer Psoriasis zu werten sind , ist noch umstritten . Wir berichten ueber 2 Patienten mit exazerbierter Psoriasis pustulosa , bei denen es zeitgleich zu Veraenderungen der Zungenschleimhaut entsprechend dem Befund einer Exfoliatio areata linguae et mucosae oris kam . Die Histologie der Schleimhaut zeigte mit ausgepraegter Akanthose , Verbreiterung der Reteleisten , fokaler Parakeratose und neutrophilem Infiltrat Veraenderungen , wie sie auch bei Psoriasis vulgaris der Haut zu finden sind . Bei den vorgestellten Patienten kam es unter systemischer Therapie mit Retinoiden zum parallelen Abheilen der Haut- und Schleimhautlaesionen . Die histopathologischen Befunde und der klinische Verlauf lassen an eine Lingua geographica als orale Manifestation einer Psoriasis pustulosa denken . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Mundschleimhautlaesionen sind wiederholt in Assoziation mit Psoriasis beschrieben worden , insbesondere mit der pustuloesen Form . Ob diese Schleimhautlaesionen als orale Manifestation einer Psoriasis zu werten sind , ist noch umstritten . Wir berichten ueber 2 Patienten mit exazerbierter Psoriasis pustulosa , bei denen es zeitgleich zu Veraenderungen der Zungenschleimhaut entsprechend dem Befund einer Exfoliatio areata linguae et mucosae oris kam . Die Histologie der Schleimhaut zeigte mit ausgepraegter Akanthose , Verbreiterung der Reteleisten , fokaler Parakeratose und neutrophilem Infiltrat Veraenderungen , wie sie auch bei Psoriasis vulgaris der Haut zu finden sind . Bei den vorgestellten Patienten kam es unter systemischer Therapie mit Retinoiden zum parallelen Abheilen der Haut- und Schleimhautlaesionen . Die histopathologischen Befunde und der klinische Verlauf lassen an eine Lingua geographica als orale Manifestation einer Psoriasis pustulosa denken .
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[ "umlsterm" ]
Mundschleimhautlaesionen is an umlsterm, Assoziation is an umlsterm, Psoriasis is an umlsterm, Schleimhautlaesionen is an umlsterm, orale Manifestation is an umlsterm, Psoriasis is an umlsterm, Patienten is an umlsterm, Psoriasis is an umlsterm, Zungenschleimhaut is an umlsterm, Histologie is an umlsterm, Schleimhaut is an umlsterm, Parakeratose is an umlsterm, Psoriasis is an umlsterm, Haut is an umlsterm, Patienten is an umlsterm, Therapie is an umlsterm, Haut- is an umlsterm, Schleimhautlaesionen is an umlsterm, Lingua geographica is an umlsterm, orale Manifestation is an umlsterm, Psoriasis is an umlsterm
DerHautarzt.80490850.ger.abstr_task1
Sentence: Mundschleimhautlaesionen sind wiederholt in Assoziation mit Psoriasis beschrieben worden , insbesondere mit der pustuloesen Form . Ob diese Schleimhautlaesionen als orale Manifestation einer Psoriasis zu werten sind , ist noch umstritten . Wir berichten ueber 2 Patienten mit exazerbierter Psoriasis pustulosa , bei denen es zeitgleich zu Veraenderungen der Zungenschleimhaut entsprechend dem Befund einer Exfoliatio areata linguae et mucosae oris kam . Die Histologie der Schleimhaut zeigte mit ausgepraegter Akanthose , Verbreiterung der Reteleisten , fokaler Parakeratose und neutrophilem Infiltrat Veraenderungen , wie sie auch bei Psoriasis vulgaris der Haut zu finden sind . Bei den vorgestellten Patienten kam es unter systemischer Therapie mit Retinoiden zum parallelen Abheilen der Haut- und Schleimhautlaesionen . Die histopathologischen Befunde und der klinische Verlauf lassen an eine Lingua geographica als orale Manifestation einer Psoriasis pustulosa denken . Instructions: please typing these entity words according to sentence: Mundschleimhautlaesionen, Assoziation, Psoriasis, Schleimhautlaesionen, orale Manifestation, Psoriasis, Patienten, Psoriasis, Zungenschleimhaut, Histologie, Schleimhaut, Parakeratose, Psoriasis, Haut, Patienten, Therapie, Haut-, Schleimhautlaesionen, Lingua geographica, orale Manifestation, Psoriasis Options: umlsterm
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Mundschleimhautlaesionen sind wiederholt in Assoziation mit Psoriasis beschrieben worden , insbesondere mit der pustuloesen Form . Ob diese Schleimhautlaesionen als orale Manifestation einer Psoriasis zu werten sind , ist noch umstritten . Wir berichten ueber 2 Patienten mit exazerbierter Psoriasis pustulosa , bei denen es zeitgleich zu Veraenderungen der Zungenschleimhaut entsprechend dem Befund einer Exfoliatio areata linguae et mucosae oris kam . Die Histologie der Schleimhaut zeigte mit ausgepraegter Akanthose , Verbreiterung der Reteleisten , fokaler Parakeratose und neutrophilem Infiltrat Veraenderungen , wie sie auch bei Psoriasis vulgaris der Haut zu finden sind . Bei den vorgestellten Patienten kam es unter systemischer Therapie mit Retinoiden zum parallelen Abheilen der Haut- und Schleimhautlaesionen . Die histopathologischen Befunde und der klinische Verlauf lassen an eine Lingua geographica als orale Manifestation einer Psoriasis pustulosa denken .
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[ "umlsterm" ]
Mundschleimhautlaesionen, Assoziation, Psoriasis, Schleimhautlaesionen, orale Manifestation, Psoriasis, Patienten, Psoriasis, Zungenschleimhaut, Histologie, Schleimhaut, Parakeratose, Psoriasis, Haut, Patienten, Therapie, Haut-, Schleimhautlaesionen, Lingua geographica, orale Manifestation, Psoriasis
DerHautarzt.80490850.ger.abstr_task2
Sentence: Mundschleimhautlaesionen sind wiederholt in Assoziation mit Psoriasis beschrieben worden , insbesondere mit der pustuloesen Form . Ob diese Schleimhautlaesionen als orale Manifestation einer Psoriasis zu werten sind , ist noch umstritten . Wir berichten ueber 2 Patienten mit exazerbierter Psoriasis pustulosa , bei denen es zeitgleich zu Veraenderungen der Zungenschleimhaut entsprechend dem Befund einer Exfoliatio areata linguae et mucosae oris kam . Die Histologie der Schleimhaut zeigte mit ausgepraegter Akanthose , Verbreiterung der Reteleisten , fokaler Parakeratose und neutrophilem Infiltrat Veraenderungen , wie sie auch bei Psoriasis vulgaris der Haut zu finden sind . Bei den vorgestellten Patienten kam es unter systemischer Therapie mit Retinoiden zum parallelen Abheilen der Haut- und Schleimhautlaesionen . Die histopathologischen Befunde und der klinische Verlauf lassen an eine Lingua geographica als orale Manifestation einer Psoriasis pustulosa denken . Instructions: please extract entity words from the input sentence
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Mundschleimhautlaesionen sind wiederholt in Assoziation mit Psoriasis beschrieben worden , insbesondere mit der pustuloesen Form . Ob diese Schleimhautlaesionen als orale Manifestation einer Psoriasis zu werten sind , ist noch umstritten . Wir berichten ueber 2 Patienten mit exazerbierter Psoriasis pustulosa , bei denen es zeitgleich zu Veraenderungen der Zungenschleimhaut entsprechend dem Befund einer Exfoliatio areata linguae et mucosae oris kam . Die Histologie der Schleimhaut zeigte mit ausgepraegter Akanthose , Verbreiterung der Reteleisten , fokaler Parakeratose und neutrophilem Infiltrat Veraenderungen , wie sie auch bei Psoriasis vulgaris der Haut zu finden sind . Bei den vorgestellten Patienten kam es unter systemischer Therapie mit Retinoiden zum parallelen Abheilen der Haut- und Schleimhautlaesionen . Die histopathologischen Befunde und der klinische Verlauf lassen an eine Lingua geographica als orale Manifestation einer Psoriasis pustulosa denken .
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[ "umlsterm" ]
patient withdrawal on a study is a Participant_Condition, pharmacist management of hypertension is a Intervention_Other, Four hundred sixty - three patients is a Participant_Sample-size, a last documented systolic blood pressure is a Participant_Condition, diastolic blood pressure is a Participant_Condition, pharmacist intervention is a Intervention_Other, usual - care ( control ) group is a Intervention_Control, collaboratively managed by a primary care clinical pharmacy specialist and their primary care provider is a Intervention_Educational, received usual care from only their primary care provider is a Intervention_Educational, 463 is a Participant_Sample-size, 191 is a Participant_Sample-size, 272 is a Participant_Sample-size, insurance status is a Outcome_Other
28408_task0
Sentence: Effect of patient withdrawal on a study evaluating pharmacist management of hypertension . STUDY OBJECTIVES To examine potential threats to internal and external study validity caused by differential patient withdrawal from a randomized controlled trial evaluating pharmacist management of hypertension , to compare the characteristics of patients who withdrew with those of patients who completed the study , and to identify characteristics that predispose patients to withdraw from hypertension management . DESIGN Prospective , randomized , comparative study . SETTING Network of primary care clinics . PATIENTS Four hundred sixty-three patients with a diagnosis of hypertension and a last documented systolic blood pressure of 160 mm Hg or greater and/or diastolic blood pressure of 100 mm Hg or greater . INTERVENTION Patients were randomly allocated to the pharmacist intervention or usual-care ( control ) group . Those in the pharmacist intervention group were collaboratively managed by a primary care clinical pharmacy specialist and their primary care provider . Patients in the control group received usual care from only their primary care provider . MEASUREMENTS AND MAIN RESULTS Of the 463 patients , 191 ( 41 % ) withdrew from the study after randomization and 272 ( 59 % ) completed the study . Patients who withdrew from the pharmacist intervention group were similar to patients who withdrew from the usual-care group with respect to age , sex , insurance status , and chronic conditions . Patients who smoked or had commercial insurance were more likely to withdraw from the study than the other participants . However , multivariate analysis of all variables , when adjusted for the effect of the intervention , revealed that insurance status was the only variable associated with a heightened probability of withdrawal ( p=0.002 ) . CONCLUSION Although this study had a high withdrawal rate , between-group patient characteristics remained balanced . Therefore , internal validity was preserved , and outcomes from the study groups could be reliably compared . A lack of significant differences between patients who withdrew versus those who completed , with the exception of insurance status , suggests that external validity was not jeopardized . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Control, Participant_Condition, Intervention_Educational, Intervention_Other, Participant_Sample-size, Outcome_Other
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Effect of patient withdrawal on a study evaluating pharmacist management of hypertension . STUDY OBJECTIVES To examine potential threats to internal and external study validity caused by differential patient withdrawal from a randomized controlled trial evaluating pharmacist management of hypertension , to compare the characteristics of patients who withdrew with those of patients who completed the study , and to identify characteristics that predispose patients to withdraw from hypertension management . DESIGN Prospective , randomized , comparative study . SETTING Network of primary care clinics . PATIENTS Four hundred sixty-three patients with a diagnosis of hypertension and a last documented systolic blood pressure of 160 mm Hg or greater and/or diastolic blood pressure of 100 mm Hg or greater . INTERVENTION Patients were randomly allocated to the pharmacist intervention or usual-care ( control ) group . Those in the pharmacist intervention group were collaboratively managed by a primary care clinical pharmacy specialist and their primary care provider . Patients in the control group received usual care from only their primary care provider . MEASUREMENTS AND MAIN RESULTS Of the 463 patients , 191 ( 41 % ) withdrew from the study after randomization and 272 ( 59 % ) completed the study . Patients who withdrew from the pharmacist intervention group were similar to patients who withdrew from the usual-care group with respect to age , sex , insurance status , and chronic conditions . Patients who smoked or had commercial insurance were more likely to withdraw from the study than the other participants . However , multivariate analysis of all variables , when adjusted for the effect of the intervention , revealed that insurance status was the only variable associated with a heightened probability of withdrawal ( p=0.002 ) . CONCLUSION Although this study had a high withdrawal rate , between-group patient characteristics remained balanced . Therefore , internal validity was preserved , and outcomes from the study groups could be reliably compared . A lack of significant differences between patients who withdrew versus those who completed , with the exception of insurance status , suggests that external validity was not jeopardized .
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[ "Intervention_Educational", "Participant_Condition", "Intervention_Other", "Participant_Sample-size", "Intervention_Control", "Outcome_Other" ]
patient withdrawal on a study is a Participant_Condition, pharmacist management of hypertension is a Intervention_Other, Four hundred sixty - three patients is a Participant_Sample-size, a last documented systolic blood pressure is a Participant_Condition, diastolic blood pressure is a Participant_Condition, pharmacist intervention is a Intervention_Other, usual - care ( control ) group is a Intervention_Control, collaboratively managed by a primary care clinical pharmacy specialist and their primary care provider is a Intervention_Educational, received usual care from only their primary care provider is a Intervention_Educational, 463 is a Participant_Sample-size, 191 is a Participant_Sample-size, 272 is a Participant_Sample-size, insurance status is a Outcome_Other
28408_task1
Sentence: Effect of patient withdrawal on a study evaluating pharmacist management of hypertension . STUDY OBJECTIVES To examine potential threats to internal and external study validity caused by differential patient withdrawal from a randomized controlled trial evaluating pharmacist management of hypertension , to compare the characteristics of patients who withdrew with those of patients who completed the study , and to identify characteristics that predispose patients to withdraw from hypertension management . DESIGN Prospective , randomized , comparative study . SETTING Network of primary care clinics . PATIENTS Four hundred sixty-three patients with a diagnosis of hypertension and a last documented systolic blood pressure of 160 mm Hg or greater and/or diastolic blood pressure of 100 mm Hg or greater . INTERVENTION Patients were randomly allocated to the pharmacist intervention or usual-care ( control ) group . Those in the pharmacist intervention group were collaboratively managed by a primary care clinical pharmacy specialist and their primary care provider . Patients in the control group received usual care from only their primary care provider . MEASUREMENTS AND MAIN RESULTS Of the 463 patients , 191 ( 41 % ) withdrew from the study after randomization and 272 ( 59 % ) completed the study . Patients who withdrew from the pharmacist intervention group were similar to patients who withdrew from the usual-care group with respect to age , sex , insurance status , and chronic conditions . Patients who smoked or had commercial insurance were more likely to withdraw from the study than the other participants . However , multivariate analysis of all variables , when adjusted for the effect of the intervention , revealed that insurance status was the only variable associated with a heightened probability of withdrawal ( p=0.002 ) . CONCLUSION Although this study had a high withdrawal rate , between-group patient characteristics remained balanced . Therefore , internal validity was preserved , and outcomes from the study groups could be reliably compared . A lack of significant differences between patients who withdrew versus those who completed , with the exception of insurance status , suggests that external validity was not jeopardized . Instructions: please typing these entity words according to sentence: patient withdrawal on a study, pharmacist management of hypertension, Four hundred sixty - three patients, a last documented systolic blood pressure, diastolic blood pressure, pharmacist intervention, usual - care ( control ) group, collaboratively managed by a primary care clinical pharmacy specialist and their primary care provider, received usual care from only their primary care provider, 463, 191, 272, insurance status Options: Intervention_Control, Participant_Condition, Intervention_Educational, Intervention_Other, Participant_Sample-size, Outcome_Other
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Effect of patient withdrawal on a study evaluating pharmacist management of hypertension . STUDY OBJECTIVES To examine potential threats to internal and external study validity caused by differential patient withdrawal from a randomized controlled trial evaluating pharmacist management of hypertension , to compare the characteristics of patients who withdrew with those of patients who completed the study , and to identify characteristics that predispose patients to withdraw from hypertension management . DESIGN Prospective , randomized , comparative study . SETTING Network of primary care clinics . PATIENTS Four hundred sixty-three patients with a diagnosis of hypertension and a last documented systolic blood pressure of 160 mm Hg or greater and/or diastolic blood pressure of 100 mm Hg or greater . INTERVENTION Patients were randomly allocated to the pharmacist intervention or usual-care ( control ) group . Those in the pharmacist intervention group were collaboratively managed by a primary care clinical pharmacy specialist and their primary care provider . Patients in the control group received usual care from only their primary care provider . MEASUREMENTS AND MAIN RESULTS Of the 463 patients , 191 ( 41 % ) withdrew from the study after randomization and 272 ( 59 % ) completed the study . Patients who withdrew from the pharmacist intervention group were similar to patients who withdrew from the usual-care group with respect to age , sex , insurance status , and chronic conditions . Patients who smoked or had commercial insurance were more likely to withdraw from the study than the other participants . However , multivariate analysis of all variables , when adjusted for the effect of the intervention , revealed that insurance status was the only variable associated with a heightened probability of withdrawal ( p=0.002 ) . CONCLUSION Although this study had a high withdrawal rate , between-group patient characteristics remained balanced . Therefore , internal validity was preserved , and outcomes from the study groups could be reliably compared . A lack of significant differences between patients who withdrew versus those who completed , with the exception of insurance status , suggests that external validity was not jeopardized .
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[ "Intervention_Educational", "Participant_Condition", "Intervention_Other", "Participant_Sample-size", "Intervention_Control", "Outcome_Other" ]
patient withdrawal on a study, pharmacist management of hypertension, Four hundred sixty - three patients, a last documented systolic blood pressure, diastolic blood pressure, pharmacist intervention, usual - care ( control ) group, collaboratively managed by a primary care clinical pharmacy specialist and their primary care provider, received usual care from only their primary care provider, 463, 191, 272, insurance status
28408_task2
Sentence: Effect of patient withdrawal on a study evaluating pharmacist management of hypertension . STUDY OBJECTIVES To examine potential threats to internal and external study validity caused by differential patient withdrawal from a randomized controlled trial evaluating pharmacist management of hypertension , to compare the characteristics of patients who withdrew with those of patients who completed the study , and to identify characteristics that predispose patients to withdraw from hypertension management . DESIGN Prospective , randomized , comparative study . SETTING Network of primary care clinics . PATIENTS Four hundred sixty-three patients with a diagnosis of hypertension and a last documented systolic blood pressure of 160 mm Hg or greater and/or diastolic blood pressure of 100 mm Hg or greater . INTERVENTION Patients were randomly allocated to the pharmacist intervention or usual-care ( control ) group . Those in the pharmacist intervention group were collaboratively managed by a primary care clinical pharmacy specialist and their primary care provider . Patients in the control group received usual care from only their primary care provider . MEASUREMENTS AND MAIN RESULTS Of the 463 patients , 191 ( 41 % ) withdrew from the study after randomization and 272 ( 59 % ) completed the study . Patients who withdrew from the pharmacist intervention group were similar to patients who withdrew from the usual-care group with respect to age , sex , insurance status , and chronic conditions . Patients who smoked or had commercial insurance were more likely to withdraw from the study than the other participants . However , multivariate analysis of all variables , when adjusted for the effect of the intervention , revealed that insurance status was the only variable associated with a heightened probability of withdrawal ( p=0.002 ) . CONCLUSION Although this study had a high withdrawal rate , between-group patient characteristics remained balanced . Therefore , internal validity was preserved , and outcomes from the study groups could be reliably compared . A lack of significant differences between patients who withdrew versus those who completed , with the exception of insurance status , suggests that external validity was not jeopardized . Instructions: please extract entity words from the input sentence
[ "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "B-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Other", "I-Intervention_Other", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Effect of patient withdrawal on a study evaluating pharmacist management of hypertension . STUDY OBJECTIVES To examine potential threats to internal and external study validity caused by differential patient withdrawal from a randomized controlled trial evaluating pharmacist management of hypertension , to compare the characteristics of patients who withdrew with those of patients who completed the study , and to identify characteristics that predispose patients to withdraw from hypertension management . DESIGN Prospective , randomized , comparative study . SETTING Network of primary care clinics . PATIENTS Four hundred sixty-three patients with a diagnosis of hypertension and a last documented systolic blood pressure of 160 mm Hg or greater and/or diastolic blood pressure of 100 mm Hg or greater . INTERVENTION Patients were randomly allocated to the pharmacist intervention or usual-care ( control ) group . Those in the pharmacist intervention group were collaboratively managed by a primary care clinical pharmacy specialist and their primary care provider . Patients in the control group received usual care from only their primary care provider . MEASUREMENTS AND MAIN RESULTS Of the 463 patients , 191 ( 41 % ) withdrew from the study after randomization and 272 ( 59 % ) completed the study . Patients who withdrew from the pharmacist intervention group were similar to patients who withdrew from the usual-care group with respect to age , sex , insurance status , and chronic conditions . Patients who smoked or had commercial insurance were more likely to withdraw from the study than the other participants . However , multivariate analysis of all variables , when adjusted for the effect of the intervention , revealed that insurance status was the only variable associated with a heightened probability of withdrawal ( p=0.002 ) . CONCLUSION Although this study had a high withdrawal rate , between-group patient characteristics remained balanced . Therefore , internal validity was preserved , and outcomes from the study groups could be reliably compared . A lack of significant differences between patients who withdrew versus those who completed , with the exception of insurance status , suggests that external validity was not jeopardized .
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[ "Intervention_Educational", "Participant_Condition", "Intervention_Other", "Participant_Sample-size", "Intervention_Control", "Outcome_Other" ]
microRNAs is a Non-Specific_miRNAs, associated is a Relation_Trigger, Parkinsońs disease is a Diseases
36_task0
Sentence: Identification of blood microRNAs associated to Parkinsońs disease. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Relation_Trigger, Diseases, Non-Specific_miRNAs
[ "O", "O", "O", "B-Non-Specific_miRNAs", "B-Relation_Trigger", "O", "B-Diseases", "I-Diseases", "O", "O" ]
Identification of blood microRNAs associated to Parkinsońs disease.
[ "Identification", "of", "blood", "microRNAs", "associated", "to", "Parkinsońs", "disease", ".", " " ]
[ "Relation_Trigger", "Diseases", "Non-Specific_miRNAs", "Specific_miRNAs", "Species" ]
microRNAs is a Non-Specific_miRNAs, associated is a Relation_Trigger, Parkinsońs disease is a Diseases
36_task1
Sentence: Identification of blood microRNAs associated to Parkinsońs disease. Instructions: please typing these entity words according to sentence: microRNAs, associated, Parkinsońs disease Options: Relation_Trigger, Diseases, Non-Specific_miRNAs
[ "O", "O", "O", "B-Non-Specific_miRNAs", "B-Relation_Trigger", "O", "B-Diseases", "I-Diseases", "O", "O" ]
Identification of blood microRNAs associated to Parkinsońs disease.
[ "Identification", "of", "blood", "microRNAs", "associated", "to", "Parkinsońs", "disease", ".", " " ]
[ "Relation_Trigger", "Diseases", "Non-Specific_miRNAs", "Specific_miRNAs", "Species" ]
microRNAs, associated, Parkinsońs disease
36_task2
Sentence: Identification of blood microRNAs associated to Parkinsońs disease. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "B-Non-Specific_miRNAs", "B-Relation_Trigger", "O", "B-Diseases", "I-Diseases", "O", "O" ]
Identification of blood microRNAs associated to Parkinsońs disease.
[ "Identification", "of", "blood", "microRNAs", "associated", "to", "Parkinsońs", "disease", ".", " " ]
[ "Relation_Trigger", "Diseases", "Non-Specific_miRNAs", "Specific_miRNAs", "Species" ]
Patienten is an umlsterm, Transplantatniere is an umlsterm, Patienten is an umlsterm, Nephrektomien is an umlsterm, Patienten is an umlsterm, Diagnose is an umlsterm, niereninsuffizient is an umlsterm, Tumorhistologie is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Nierentransplantat is an umlsterm, Dialysengruppe is an umlsterm, Fernmetastasen is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Tumorwachstum is an umlsterm, Fernmetastasen is an umlsterm, Patienten is an umlsterm, Tumorwachstum is an umlsterm, Patientenpopulation is an umlsterm, Eigenniere is an umlsterm, Nierentransplantation is an umlsterm
DerUrologeA.70360126.ger.abstr_task0
Sentence: In dieser retroperspektiven Studie untersuchten wir die klinische Wertigkeit des De-novo-Nierenzellkarzinoms bei chronisch dialysepflichtigen Patienten im Vergleich zu Empfaengern einer Transplantatniere . Im Zeitraum der letzten 15 Jahre beobachteten wir den klinischen Verlauf dieser Patienten . Von 788 durchgefuehrten Nephrektomien konnten 21 Patienten identifiziert werden , die zum Zeitpunkt der Diagnose des Nierenzellkarzinoms terminal niereninsuffizient waren . Ausgewertet wurden Daten zur klinischen Symptomatik , Tumorhistologie und zum klinischen Verlauf . 14 Patienten waren in chronischer Haemodialysebehandlung , 7 Patienten verfuegten ueber ein stabiles Nierentransplantat . 92 % der Dialysengruppe hatte zum Zeitpunkt der Operation keine Fernmetastasen , keiner dieser Patienten ist bisher an dem RCC verstorben . 71 % der transplantierten Patienten hatte hingegen zum Zeitpunkt der Operation ein bereits organueberschreitendes Tumorwachstum oder Fernmetastasen . 3 Patienten sind zwischenzeitlich an ihrer Erkrankung verstorben . Das aggressive Tumorwachstum des Nierenzellkarzinoms in dieser Patientenpopulation macht somit eine engmaschige Kontrolle der Eigenniere vor und nach Nierentransplantation erforderlich . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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In dieser retroperspektiven Studie untersuchten wir die klinische Wertigkeit des De-novo-Nierenzellkarzinoms bei chronisch dialysepflichtigen Patienten im Vergleich zu Empfaengern einer Transplantatniere . Im Zeitraum der letzten 15 Jahre beobachteten wir den klinischen Verlauf dieser Patienten . Von 788 durchgefuehrten Nephrektomien konnten 21 Patienten identifiziert werden , die zum Zeitpunkt der Diagnose des Nierenzellkarzinoms terminal niereninsuffizient waren . Ausgewertet wurden Daten zur klinischen Symptomatik , Tumorhistologie und zum klinischen Verlauf . 14 Patienten waren in chronischer Haemodialysebehandlung , 7 Patienten verfuegten ueber ein stabiles Nierentransplantat . 92 % der Dialysengruppe hatte zum Zeitpunkt der Operation keine Fernmetastasen , keiner dieser Patienten ist bisher an dem RCC verstorben . 71 % der transplantierten Patienten hatte hingegen zum Zeitpunkt der Operation ein bereits organueberschreitendes Tumorwachstum oder Fernmetastasen . 3 Patienten sind zwischenzeitlich an ihrer Erkrankung verstorben . Das aggressive Tumorwachstum des Nierenzellkarzinoms in dieser Patientenpopulation macht somit eine engmaschige Kontrolle der Eigenniere vor und nach Nierentransplantation erforderlich .
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[ "umlsterm" ]
Patienten is an umlsterm, Transplantatniere is an umlsterm, Patienten is an umlsterm, Nephrektomien is an umlsterm, Patienten is an umlsterm, Diagnose is an umlsterm, niereninsuffizient is an umlsterm, Tumorhistologie is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Nierentransplantat is an umlsterm, Dialysengruppe is an umlsterm, Fernmetastasen is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Tumorwachstum is an umlsterm, Fernmetastasen is an umlsterm, Patienten is an umlsterm, Tumorwachstum is an umlsterm, Patientenpopulation is an umlsterm, Eigenniere is an umlsterm, Nierentransplantation is an umlsterm
DerUrologeA.70360126.ger.abstr_task1
Sentence: In dieser retroperspektiven Studie untersuchten wir die klinische Wertigkeit des De-novo-Nierenzellkarzinoms bei chronisch dialysepflichtigen Patienten im Vergleich zu Empfaengern einer Transplantatniere . Im Zeitraum der letzten 15 Jahre beobachteten wir den klinischen Verlauf dieser Patienten . Von 788 durchgefuehrten Nephrektomien konnten 21 Patienten identifiziert werden , die zum Zeitpunkt der Diagnose des Nierenzellkarzinoms terminal niereninsuffizient waren . Ausgewertet wurden Daten zur klinischen Symptomatik , Tumorhistologie und zum klinischen Verlauf . 14 Patienten waren in chronischer Haemodialysebehandlung , 7 Patienten verfuegten ueber ein stabiles Nierentransplantat . 92 % der Dialysengruppe hatte zum Zeitpunkt der Operation keine Fernmetastasen , keiner dieser Patienten ist bisher an dem RCC verstorben . 71 % der transplantierten Patienten hatte hingegen zum Zeitpunkt der Operation ein bereits organueberschreitendes Tumorwachstum oder Fernmetastasen . 3 Patienten sind zwischenzeitlich an ihrer Erkrankung verstorben . Das aggressive Tumorwachstum des Nierenzellkarzinoms in dieser Patientenpopulation macht somit eine engmaschige Kontrolle der Eigenniere vor und nach Nierentransplantation erforderlich . Instructions: please typing these entity words according to sentence: Patienten, Transplantatniere, Patienten, Nephrektomien, Patienten, Diagnose, niereninsuffizient, Tumorhistologie, Patienten, Patienten, Nierentransplantat, Dialysengruppe, Fernmetastasen, Patienten, Patienten, Tumorwachstum, Fernmetastasen, Patienten, Tumorwachstum, Patientenpopulation, Eigenniere, Nierentransplantation Options: umlsterm
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In dieser retroperspektiven Studie untersuchten wir die klinische Wertigkeit des De-novo-Nierenzellkarzinoms bei chronisch dialysepflichtigen Patienten im Vergleich zu Empfaengern einer Transplantatniere . Im Zeitraum der letzten 15 Jahre beobachteten wir den klinischen Verlauf dieser Patienten . Von 788 durchgefuehrten Nephrektomien konnten 21 Patienten identifiziert werden , die zum Zeitpunkt der Diagnose des Nierenzellkarzinoms terminal niereninsuffizient waren . Ausgewertet wurden Daten zur klinischen Symptomatik , Tumorhistologie und zum klinischen Verlauf . 14 Patienten waren in chronischer Haemodialysebehandlung , 7 Patienten verfuegten ueber ein stabiles Nierentransplantat . 92 % der Dialysengruppe hatte zum Zeitpunkt der Operation keine Fernmetastasen , keiner dieser Patienten ist bisher an dem RCC verstorben . 71 % der transplantierten Patienten hatte hingegen zum Zeitpunkt der Operation ein bereits organueberschreitendes Tumorwachstum oder Fernmetastasen . 3 Patienten sind zwischenzeitlich an ihrer Erkrankung verstorben . Das aggressive Tumorwachstum des Nierenzellkarzinoms in dieser Patientenpopulation macht somit eine engmaschige Kontrolle der Eigenniere vor und nach Nierentransplantation erforderlich .
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[ "umlsterm" ]
Patienten, Transplantatniere, Patienten, Nephrektomien, Patienten, Diagnose, niereninsuffizient, Tumorhistologie, Patienten, Patienten, Nierentransplantat, Dialysengruppe, Fernmetastasen, Patienten, Patienten, Tumorwachstum, Fernmetastasen, Patienten, Tumorwachstum, Patientenpopulation, Eigenniere, Nierentransplantation
DerUrologeA.70360126.ger.abstr_task2
Sentence: In dieser retroperspektiven Studie untersuchten wir die klinische Wertigkeit des De-novo-Nierenzellkarzinoms bei chronisch dialysepflichtigen Patienten im Vergleich zu Empfaengern einer Transplantatniere . Im Zeitraum der letzten 15 Jahre beobachteten wir den klinischen Verlauf dieser Patienten . Von 788 durchgefuehrten Nephrektomien konnten 21 Patienten identifiziert werden , die zum Zeitpunkt der Diagnose des Nierenzellkarzinoms terminal niereninsuffizient waren . Ausgewertet wurden Daten zur klinischen Symptomatik , Tumorhistologie und zum klinischen Verlauf . 14 Patienten waren in chronischer Haemodialysebehandlung , 7 Patienten verfuegten ueber ein stabiles Nierentransplantat . 92 % der Dialysengruppe hatte zum Zeitpunkt der Operation keine Fernmetastasen , keiner dieser Patienten ist bisher an dem RCC verstorben . 71 % der transplantierten Patienten hatte hingegen zum Zeitpunkt der Operation ein bereits organueberschreitendes Tumorwachstum oder Fernmetastasen . 3 Patienten sind zwischenzeitlich an ihrer Erkrankung verstorben . Das aggressive Tumorwachstum des Nierenzellkarzinoms in dieser Patientenpopulation macht somit eine engmaschige Kontrolle der Eigenniere vor und nach Nierentransplantation erforderlich . Instructions: please extract entity words from the input sentence
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In dieser retroperspektiven Studie untersuchten wir die klinische Wertigkeit des De-novo-Nierenzellkarzinoms bei chronisch dialysepflichtigen Patienten im Vergleich zu Empfaengern einer Transplantatniere . Im Zeitraum der letzten 15 Jahre beobachteten wir den klinischen Verlauf dieser Patienten . Von 788 durchgefuehrten Nephrektomien konnten 21 Patienten identifiziert werden , die zum Zeitpunkt der Diagnose des Nierenzellkarzinoms terminal niereninsuffizient waren . Ausgewertet wurden Daten zur klinischen Symptomatik , Tumorhistologie und zum klinischen Verlauf . 14 Patienten waren in chronischer Haemodialysebehandlung , 7 Patienten verfuegten ueber ein stabiles Nierentransplantat . 92 % der Dialysengruppe hatte zum Zeitpunkt der Operation keine Fernmetastasen , keiner dieser Patienten ist bisher an dem RCC verstorben . 71 % der transplantierten Patienten hatte hingegen zum Zeitpunkt der Operation ein bereits organueberschreitendes Tumorwachstum oder Fernmetastasen . 3 Patienten sind zwischenzeitlich an ihrer Erkrankung verstorben . Das aggressive Tumorwachstum des Nierenzellkarzinoms in dieser Patientenpopulation macht somit eine engmaschige Kontrolle der Eigenniere vor und nach Nierentransplantation erforderlich .
[ "In", "dieser", "retroperspektiven", "Studie", "untersuchten", "wir", "die", "klinische", "Wertigkeit", "des", "De", "-", "novo", "-", "Nierenzellkarzinoms", "bei", "chronisch", "dialysepflichtigen", "Patienten", "im", "Vergleich", "zu", "Empfaengern", "einer", "Transplantatniere", ".", "Im", "Zeitraum", "der", "letzten", "15", "Jahre", "beobachteten", "wir", "den", "klinischen", "Verlauf", "dieser", "Patienten", ".", "Von", "788", "durchgefuehrten", "Nephrektomien", "konnten", "21", "Patienten", "identifiziert", "werden", ",", "die", "zum", "Zeitpunkt", "der", "Diagnose", "des", "Nierenzellkarzinoms", "terminal", "niereninsuffizient", "waren", ".", "Ausgewertet", "wurden", "Daten", "zur", "klinischen", "Symptomatik", ",", "Tumorhistologie", "und", "zum", "klinischen", "Verlauf", ".", "14", "Patienten", "waren", "in", "chronischer", "Haemodialysebehandlung", ",", "7", "Patienten", "verfuegten", "ueber", "ein", "stabiles", "Nierentransplantat", ".", "92", "%", "der", "Dialysengruppe", "hatte", "zum", "Zeitpunkt", "der", "Operation", "keine", "Fernmetastasen", ",", "keiner", "dieser", "Patienten", "ist", "bisher", "an", "dem", "RCC", "verstorben", ".", "71", "%", "der", "transplantierten", "Patienten", "hatte", "hingegen", "zum", "Zeitpunkt", "der", "Operation", "ein", "bereits", "organueberschreitendes", "Tumorwachstum", "oder", "Fernmetastasen", ".", "3", "Patienten", "sind", "zwischenzeitlich", "an", "ihrer", "Erkrankung", "verstorben", ".", "Das", "aggressive", "Tumorwachstum", "des", "Nierenzellkarzinoms", "in", "dieser", "Patientenpopulation", "macht", "somit", "eine", "engmaschige", "Kontrolle", "der", "Eigenniere", "vor", "und", "nach", "Nierentransplantation", "erforderlich", "." ]
[ "umlsterm" ]
Autosomal - recessive cerebellar ataxias is a Diseases, neurodegenerative disorders is a Diseases
7775_task0
Sentence: Autosomal-recessive cerebellar ataxias comprise a clinically and genetically heterogeneous group of neurodegenerative disorders. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Diseases
[ "B-Diseases", "I-Diseases", "I-Diseases", "I-Diseases", "I-Diseases", "O", "O", "O", "O", "O", "O", "O", "O", "B-Diseases", "I-Diseases", "O" ]
Autosomal-recessive cerebellar ataxias comprise a clinically and genetically heterogeneous group of neurodegenerative disorders.
[ "Autosomal", "-", "recessive", "cerebellar", "ataxias", "comprise", "a", "clinically", "and", "genetically", "heterogeneous", "group", "of", "neurodegenerative", "disorders", "." ]
[ "Diseases", "Genes/Proteins", "Relation_Trigger", "Species" ]
Autosomal - recessive cerebellar ataxias is a Diseases, neurodegenerative disorders is a Diseases
7775_task1
Sentence: Autosomal-recessive cerebellar ataxias comprise a clinically and genetically heterogeneous group of neurodegenerative disorders. Instructions: please typing these entity words according to sentence: Autosomal - recessive cerebellar ataxias, neurodegenerative disorders Options: Diseases
[ "B-Diseases", "I-Diseases", "I-Diseases", "I-Diseases", "I-Diseases", "O", "O", "O", "O", "O", "O", "O", "O", "B-Diseases", "I-Diseases", "O" ]
Autosomal-recessive cerebellar ataxias comprise a clinically and genetically heterogeneous group of neurodegenerative disorders.
[ "Autosomal", "-", "recessive", "cerebellar", "ataxias", "comprise", "a", "clinically", "and", "genetically", "heterogeneous", "group", "of", "neurodegenerative", "disorders", "." ]
[ "Diseases", "Genes/Proteins", "Relation_Trigger", "Species" ]
Autosomal - recessive cerebellar ataxias, neurodegenerative disorders
7775_task2
Sentence: Autosomal-recessive cerebellar ataxias comprise a clinically and genetically heterogeneous group of neurodegenerative disorders. Instructions: please extract entity words from the input sentence
[ "B-Diseases", "I-Diseases", "I-Diseases", "I-Diseases", "I-Diseases", "O", "O", "O", "O", "O", "O", "O", "O", "B-Diseases", "I-Diseases", "O" ]
Autosomal-recessive cerebellar ataxias comprise a clinically and genetically heterogeneous group of neurodegenerative disorders.
[ "Autosomal", "-", "recessive", "cerebellar", "ataxias", "comprise", "a", "clinically", "and", "genetically", "heterogeneous", "group", "of", "neurodegenerative", "disorders", "." ]
[ "Diseases", "Genes/Proteins", "Relation_Trigger", "Species" ]
femoral nerves is an umlsterm, invasive procedures is an umlsterm, knee is an umlsterm, ankle joint is an umlsterm, flexibility is an umlsterm, anaesthetist 's is an umlsterm, schedule is an umlsterm, relaxation is an umlsterm, muscles is an umlsterm, contraindications is an umlsterm, arrhythmia is an umlsterm, heart is an umlsterm, lidocaine is an umlsterm, mepivacaine is an umlsterm, sciatic nerve is an umlsterm, femoral nerve is an umlsterm, book is an umlsterm, patient is an umlsterm, complications is an umlsterm, operation is an umlsterm, pain is an umlsterm
Arthroskopie.80110102.eng.abstr_task0
Sentence: Block of the sciatic and femoral nerves can be performed either by the surgeon or by the anaesthetist , allowing for numerous minimally invasive procedures in the knee and ankle joint . It also offers a certain flexibility with regard to the anaesthetist's schedule and provides a good and long anaesthesia and relaxation of the quadricep and hamstring muscles . Some contraindications - arrhythmia , severe conduction disturbance and heart failure - should be considered , as well as vegetative lability and oversensitivity to xylocaine , lidocaine or mepivacaine . There is no difficulty in finding the sciatic nerve and the femoral nerve as the topography is well described by Daniel C. Moore in his book about regional block . Though easy to perform , and even when wished for by the patient , the surgeon has to be aware of possible complications . In some cases we recommend that an anaesthesiologist stand by . In only 2 of 720 cases did the operation have to be interrupted because of severe pain or unexpected difficulty . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Block of the sciatic and femoral nerves can be performed either by the surgeon or by the anaesthetist , allowing for numerous minimally invasive procedures in the knee and ankle joint . It also offers a certain flexibility with regard to the anaesthetist's schedule and provides a good and long anaesthesia and relaxation of the quadricep and hamstring muscles . Some contraindications - arrhythmia , severe conduction disturbance and heart failure - should be considered , as well as vegetative lability and oversensitivity to xylocaine , lidocaine or mepivacaine . There is no difficulty in finding the sciatic nerve and the femoral nerve as the topography is well described by Daniel C. Moore in his book about regional block . Though easy to perform , and even when wished for by the patient , the surgeon has to be aware of possible complications . In some cases we recommend that an anaesthesiologist stand by . In only 2 of 720 cases did the operation have to be interrupted because of severe pain or unexpected difficulty .
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[ "umlsterm" ]