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Paired carcinoma and para-carcinoma tissues were obtained after operation to detect the expression of PCNA protein by immunohistochemistry (IHC). | china |
After the synthesis of the new ruthenium complexes, the antiproliferative, cytotoxicity, and apoptosis activities were evaluated in vitro by the triple assay ApoTox-Glo. | not china |
However, metastases at diagnosis increased from 3.0% to 5.2% (P < .001). | not china |
Furthermore, we demonstrated for the first time that P. gingivalis enhanced the expression of Glycoprotein A repetitions predominant (GARP), thereby activating TGFβ/Smad signaling. | china |
As patients with cancer live longer and as SRS is increasingly utilized for treatment of brain metastases, the incidence of these previously rare imaging changes is likely to increase. | not china |
The CD44(+/High) subpopulation of the LMP1-transformed NPC cells displayed more significant CSC characteristics than the CD44(-/Low) subpopulation of the LMP1-transformed NPC cells; these characteristics included the upregulation of stemness-related genes, in vitro self-renewal and in vivo tumor initiation ability. | china |
Analyses were adjusted for gender, age and smoking status (Model 1), and additionally for the food groups fruit, vegetables and meat (Model 2). | not china |
ΔSUV(max) during and after CRT significantly correlated with the pathological response to treatment (during CRT: ΔSUV(max) = 59% ± 12% for pCR vs. 25% ± 27% if no pCR, p=0.0036; post-CRT: 90% ± 11 for pCR vs. 63% ± 22 if no pCR p=0.013). | not china |
Cumulative BM rates at three years were 75.8% and 24.2% for the RadBM score-high and RadBM score-low groups, respectively. | china |
Not all communication between GPs and patients was positive suggesting communication skills training may be a priority. | not china |
The MTHFR C677T polymorphism influences many biological processes, including tumorigenesis. | china |
In this paper we demonstrate that CDC25A level is controlled by a complex STAT5/miR-16 transcription and translation pathway working downstream of this receptor. | not china |
Nevertheless, an understanding of pathologic features of these tumors, especially tissue content (mucinous, fibrous) and growth pattern, can help to define some specific clues for their diagnosis. | not china |
Among the 302 NPC patients who were treated definitively with TPF neoadjuvant chemotherapy followed by IMRT concurrent with nimotuzumab or cisplatin at West China Hospital Sichuan University, 52 patients received h-R3/RT with complete clinical and follow-up data. | china |
Neoadjuvant chemotherapy (NAC) is generally accepted for treatment of liver metastasis of colorectal cancer (CRLM), but what is a reasonable interval between the latest NAC and surgery is still unknown. | china |
The IC50 value of reduced viability for DGH was 7x10-5M in U251MG cells, 5x10-5M for the T98G cells and 4x10-5M in U87G cells during 72h treatment. | not china |
For the matched cohort analysis, both univariate and adjusted analyses were carried out. | not china |
The results of relevant clinical studies indicated that down-regulation of SNCA was statistically correlated with shorter overall survival time and post-progression survival time. | china |
Compounds 3 and 4 are found to be most potent with an IC(50) of 7.53 μM and 32.26 μM on THP-1, 11.12 μM and 7.21 μM on COLO-205 cell lines, respectively. | not china |
Five-minute electrocardiogram data were collected 1 day before the operation for analysis of HRV parameters, including frequency domain parameters (LF, HF, and LF/HF) and Poincaré plot parameters (SD1, SD2, and SD2/SD1). | china |
Increasing evidence demonstrated that noncoding RNA is abnormally expressed in cancer tissues and serves a vital role in tumorigenesis, tumor development, and metastasis. | china |
The interaction between the two partners is a prerequisite for the proteolytic activation of CREB3. | not china |
Although multiple treatment modalities were given, both patients succumbed to disease progression. | china |
Importantly, phospho-RTK arrays revealed novel targets for cediranib and sunitinib therapy. | not china |
RNA pull-down experiments confirmed that miR-4651 directly binds to BRD4 mRNA. | china |
Histone H3 K27M mutation, identified in 36% of the cases, was the major prognostic determinant. | not china |
Standard MTT assay was used for accessing antiproliferative activity on CL-6 cells. | not china |
Statistical analysis showed significant differences between the ratio of correct answers and the respondent’s university affiliation (p < 0.05). | not china |
The tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) is the main block for the penetration of chemotherapy. | china |
BTBD7 may thus be a therapeutic target for lung cancer. | china |
To better understand the role of NUSAP1 in prostate cancer progression, we tested the effects of increased and decreased NUSAP1 expression in cell lines, in vivo models, and patient samples. | not china |
In this study, long intergenic nonprotein coding RNA 173 (LINC00173) was highly expressed in pancreatic cancer tissues. | china |
However, at present, there are very few research articles to study and explore the relationship between natural products and m6A RNA modification in tumorigenesis. | china |
Group II (n=12) were injected I.P. | not china |
Of 182 relevant studies, 12 were included in the final analysis, which consisted of 6844 patients with NSCLC. | china |
To the best of our knowledge, this is the first reported case of a breast neoplasm as the recipient tumor in tumor-to-tumor metastasis. | not china |
Next, the peritoneum is separated from the inside of the abdominal cavity, and the extraperitoneal tunnel is opened. | not china |
The UPRmt-mediated transcriptional program requires the participation of various upstream signaling pathways and molecules. | china |
Published articles between 2002 and 2012. | not china |
Mechanistically, we demonstrated that downregulation of CENP-E could stabilize PD-L1 mRNA through the targeting of its 3'UTR by TTP. | china |
Of these women, 22% were confirmed as ADH on surgical biopsy and 47% with a malignancy. | not china |
Notably, the number of CK-CTCs can act as independent risk factors for PFS (P = 0.044) and OS (P = 0.043) in NSCLC patients. | china |
We propose that a 2-h IIV of tacrolimus is a safe method of administration in the adult HSCT setting. | not china |
Oncologists frequently underestimate patients' depression and anxiety and should consider incorporating patient-reported outcomes to enhance monitoring of mental health symptoms. | not china |
Their stable biological characteristics, diversity of contents, non-invasiveness path for introducing signaling molecules, and ability for rapid detection make exosomes a promising clinical diagnostic marker for potentially many pathological conditions, including cancers. | china |
The LCAT1-miR-4715-5p-RAC1 axis was assessed by dual-luciferase reporter and RNA immunoprecipitation (RIP) assays. | china |
The purpose of this review is to show, with the example of netrin-1 dependence receptors, the path from cell biology to promising anticancer-targeted therapy. | not china |
Increased TG and TC levels at ALL-diagnosis were not associated with any on-therapy lipid levels. | not china |
The primary outcome was long-term (≥10 y) survival. | not china |
Organochlorine (OC) insecticides and polychlorinated biphenyls (PCBs) have been shown to have estrogenic, antiestrogenic, or antiandrogenic properties; as a result, the impact of exposure to these compounds and risk of hormonal cancers, such as prostate cancer, is a concern. | not china |
Further functional studies of the opioid growth factor receptor (OGFr), a negative biological regulator of cell proliferation in HCC, revealed that HOTAIR exerts its effects on cell proliferation, at least in part, through the regulation of OGFr expression. | china |
Quantitative investigations were mostly descriptive or observational. | china |
Secondary outcomes included the long-term appearance of locoregional recurrence, distant metastases, and second primary tumors. | not china |
Collectively, this study identifies a novel method for risk stratification of patients and provides insight into the molecular events underlying TGCT. | china |
Immunotherapy and targeted therapy for metastatic cancer may cause immune-related adverse events (irAEs) such as uveitis. | not china |
No complete response was observed. | china |
The purpose of this study was to evaluate the outcomes and cancer rate in solid palpable masses with benign features assessed as BI-RADS 3 or 4A. | not china |
Serum ROS, urinary 8-hydroxydeoxyguanosine, full blood GSH levels, and reduced/oxidized GSH ratio (GSH/GSSG) were measured. | not china |
The sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) were used to elucidate diagnostic performance, and to compare the microRNAs with α-fetoprotein (AFP) at a cutoff of 20 ng/mL (AFP20) and 400 ng/mL (AFP400). | china |
Luciferase assays further confirmed that miR-212 interacts with MIAT. | china |
They were treated with combination chemotherapy and whole exome sequencing. | china |
We identified nine TME-related prognostic genes using Cox regression analysis. | china |
Compared with before the CIK intervention, the CA125 and HE4 levels were significantly decreased, but the TGF-α and TNF-α levels were increased (P<0.05). | china |
Thus, posaconazole can interact with vincristine and induce secondary hypertension in children with ALL. | china |
A few of them are MiNENs. | not china |
Cox proportional hazard model was used for survival analysis of imaging features. | china |
This study investigates the challenges involved in the preoperative and intraoperative evaluation of MSF infiltration and analyzes its prognostic relevance. | not china |
The proliferation and invasion of cells with siXIST were significantly enhanced compared with those of control cells, while knockdown of miR-181a abolished the enhancing effects. | china |
The positive predictability of biopsy specimens to resected specimens was analyzed based on tumor fragment number. | china |
Predictors of overall survival were determined using multivariate Cox regression analyses. | not china |
Pulmonary partial resection was performed thoracoscopy. | not china |
Therefore, understanding the molecular mechanisms involved in ovarian cancer development and identification of novel therapeutic targets are urgently required. | china |
We herein demonstrated that the mono(ADP-ribosyl)ation of histone deacetylase (HDAC)1 and HDAC2 by poly(ADP-ribose) polymerase 14 (PARP14) may be required to induce the expression of EP4 receptors. | not china |
Our results demonstrated that GHET1 was up-regulated in breast cancer tissues and cell lines, and promoted breast cancer cell proliferation, invasion and migration by affecting EMT. | china |
In this study, TUSC3 expression was found to be suppressed both at mRNA and protein levels in cell line models as well as in clinical samples; decreased TUSC3 expression was associated with higher pathological TNM staging and poorer outcome. | china |
We conduct experiments on various synthetic datasets and eight public multi-view datasets from The Cancer Genome Atlas. | china |
Conditioned media (CM) from nonirradiated (SnonR), irradiated (SR), or irradiated plus radiosensitizer celecoxib-treated (S[R + D]) NPCs were collected and added to sublethal irradiated McA-RH7777 cells. | china |
Abbreviated magnetic resonance imaging (aMRI) protocols have emerged as an alternative to multiparametric MRI (mpMRI) to reduce examination time and costs. | not china |
In addition, univariate analysis revealed that high EGFL7 expression in tumor tissues was significantly associated with poor overall survival, accompanied by several conventional clinicopathological variables, such as gender, histological grade and lymph node metastasis. | china |
Educational intervention to reduce these misconceptions is needed. | not china |
Future studies should explore the extent ICH gene signature contributes to tertiary lymphoid structures or cross-talk between homing pathways. | not china |
Our study provides a potential method for screening of susceptible population of gastric cancer for early-stage intervention in patients. | china |
On the seventh day of chemotherapy, the patient entered the period of granulocyte deficiency with infection. | china |
Recent studies have shown that re-expression of stem cell factors contribute to pathogenesis, therapy resistance, and recurrent disease in ovarian carcinomas. | not china |
However, it remains unclear whether CENP-E regulates the immune microenvironment in non-small cell lung cancer (NSCLC). | china |
Only one patient developed grade II aGVHD in the DLI group. | china |
Potential associations between neurosphere formation and clinical outcome were analyzed retrospectively. | not china |
ADC, volumes and PSA as inputs to the model revealed a correlation coefficient of 0.54 (p < 0.001) between predicted and measured treatment response, while Ktrans, volumes and PSA gave a correlation coefficient of 0.66 (p < 0.001). | not china |
We further found that temozolomide activated eIF4E and this was reversed by tomivosertib. | china |
Propensity score matching was used to balance baseline differences, and 83 pairs of cases were selected. | china |
Insufficient intake frequently leads to malnutrition, which contributes to high morbidity and mortality rates. | not china |
Tumor angiogenesis is deemed to be a pivotal rate-determining step for tumor growth and metastasis. | china |
Regarding the C-KIT gene analysis, mutations in exon 11 were detected in 11 out of 13 patients. | not china |
Here, we described a macrophage-mediated photothermal therapy combined with anti-inflammatory strategy to inhibit breast cancer postoperative relapse. | china |
The application of new SOR -CAT-PLGA MSs in hepatic artery chemoembolization of rabbit VX2 liver tumor is a promising approach to improve the therapeutic effect of liver tumors and has a broad clinical application prospect. | china |
For CYP2E1 T7632A polymorphism, meta-analysis showed that there was no significant association between the CYP2E1 T7632A polymorphism and colorectal cancer risk under all contrast models (A vs. T: OR = 1.06, 95 % CI 0.88-1.29, P = 0.528; AA vs. TT: OR = 0.85, 95 % CI 0.61-1.19, P = 0.351; AA/TA vs. TT: OR = 1.08, 95 % CI 0.87-1.34, P = 0.484; and AA vs. OR = 0.87, 95 % CI 0.62-1.21, P = 0.395). | china |
The siRNA target to SLPI significantly decreased the expressions of SLPI in these PDAC cell lines. | china |
Firstly, a novel multi-scale image normalization block is designed to perform same-size and same-resolution resizing on the input data in a parallel manner. | china |
Therefore, OXCT1-AS1 may act as a prospective biomarker and therapeutic target for patients with NSCLC. | china |
In the present study, we endeavor to evaluate its expression and functions in epithelial ovarian cancer (EOC). | china |