Datasets:

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dotan1111

/

MSA-amino-10-seq

like 0

VVVVAVVVVVTTTTTTTTMTWWWWWWWWWWDGDNDDREDENNNH-NNNNNVVVAVVAIVIAAAAAAMAAALLLLIILILINNNHTNNNNNQAQAQQAQQQSSSSSASNTSASASNSSSASVVVVNLVVVVVVVVVVVVVVKKKKEKKKKKAAAYAAYAAAHHHHHHHHHKVTVTVVTTLTRNNNNNYNNNDDDDDDDDDDL-M-LL-LLLG-G-GG-EGGA-A-LI-VYVD-D-DD-DDDAPPPPPPPPPDDDDEKDEDEIVIVVVVVIVPPPPPPPPGPVVVVVIIVVINNNNSSNSNCVIVIIIIIIISSSSSSSSSSYYYIYYYYYY---T------LLLLMLLLLLFFFGFFFFFFI---------L---------I---------V---------F---------N---------E---------Q---------V-----------------L---------K---------W-LLLLVVLVLVNEEEKQEEEEKKKKKKKKKKQQQQKQQKQKDDDDDDDDDDKKKNKKKKKKVVVVIVVIVI

VAAAVVEAEASSSSSSPSPS-M-M---M---T-T---T---T-T---T---N-H---N---E-E---E---S---------Y---------G---------P---------K-K---K---F-F---F---L-L---V---A-A---A---K-K---K---T-T---S---Q-K---Q---Y-Y---Y---E-E---E---N-N---N---L-L---L---L-V---L---I-I---I---T-V---I--YYYYYIYYYYLVVVKLLVLVQQQQQQKQKQAAAAAAVAVAAAAAAATATAVVVVVVVVVVPSSSPSSSSSTMTTTTTVMTGGQGGGGGGQQQQQQQQQQKI---VII-I-F---FFM-M-D---DDD-D-S---SSS-S-I---III-I-SSSSTSSSSSLLLLLLLLLLFFFFFFFFFFIVIIIIIVIITVTTTTTTTTDDDPDDDEDDDDDDDDDDDDLLLLLLLLLLDDQDDDDDDDGNNSGNNNNDQKKKQQRKKKKQQQKKKQKQGGGGGSGGGGSSSSSSSSSSLMMMLLMMMMFRFQFFFQFFERVIVVVIVVLIVILLLILIVVVVVVVVVLHNKHHHHHHNDDDDDDDDDDSSASSSSSSALLLLLLLLLLAQQEQSQQQQMSLMMMMMMMLLLLLLLLLLLLTLMLLLLLAAAAAAAAAAAAAAAAAAAAILLLIIILIL

NDDDDDDDDNAASSSSSASTAAAEAEAAAAMWLLFLLWLLILLLILLLLIMLMLMLMMMMIIVIVIVLVVNKNNNNNKNNNEKQKQKEKNVVVVVEVVVVIMIIIVIIIINTQTNTNTNNLLLLLLLLLLEDDDEDDDDEKRKKKKKEKKIIIIIIIIIIE--------EIEMEMEMEQMYYFYYYYYFYTTTTMTTIETQLILLLLLLLRRERRRRRKRIIIIIIIIIIR---------V---------KMKMKMKMKKTSTSTTTSTTRQR-RQRQRRPPP-PPPPPPTCT-TCTCTTGTKTTTTTKIYWYWYWYWYYCCCCCCCCCCIIIIIIIIIIIMIMIMIMVIEEEEEPEEEEQNHQQQQQHQVVVVVVVVVVTTTTTTTTTTLEQQQQQEQQKKKKKKKKKK------C---KYYYYYYYYYEEEEEEEYEEQNNNNNNNNNLLALLLLLALPPPPPPPPPPFFFFVFFFFF

VVVVVVVVVVGGGGGGGGGGFFYYLFFYFFSSKKSSSKSSTTTTTQTTTTLLILLLLLFLYYYYYFYYYYVVVVVVVAVVKKKKKKKKKKYYHHHYYHYHEDEEKNDEDEEEDEEEEDEESSSSSSSSSSQQQQQQQQQQAAAAAAAAAADDDEDDDDDDLLLLLLLLLLKKKKKKKKKKYYHHYYYHYYEEEEEEEEEDRRRRRRRRKRTTTATTTTTTKKKKKKRKKKQQAAAQQAQARRKKKRRKRKDDDDDDDDDDAARAAAAAAAIVAAATVATALLLLLLLLLLAAANAAAAAARRRRRRRRRQSSCCSSSCSCLVVVVIVVIVMMLFMMMMMQ------L---------L---------F---------A---------S---------L---------Y---------I---------E---------L---------K---------I---------C---------E---------G---------L---------D---------S---------S---------L---EEEEEEEEEE

IIIITIIIIITKTKTTTKKTNNNNNNNNNNTSTTTTTSSTQQQQQQEQKQFLFL-FFLLLVVVV-VVVVV---------D---------N---------P---------G---------F---------I---------G---------L---------G---------D---------K---------N---------V---------R---------P---------K---------F---------M---------D---------Y---------ELLLI-LLILMTRTT-TTTRTGNGN-NGNNNFHFY-YYHHYT-TI-QT--IEREK-EDEEETATA-TTAAAAAAR-AAAAARRRR-RRRRRAAAA-ATAPANDND-DDDSDQ-Q--TT--ALLLL-LLLLLVIVI-IVIAINENE-NNEENYYYY-YYYYYRRRR-RRRRRLMILLILLLLTTTTTTTTTTKKKKKKKKKKTETGTTTTETLLLLLLLILLMTMMMMMLMMAASASSSSAARQRRRRRQQRAAAAAAAAAARKRRRRRKKRKNRKKKAKNK

AAAAAAAAAALLLLLLVVVVDDDDDDDDDDCCCCCCCCCCIFLLLILLLLNNNNNNNNNNDDDDDDNNENCFCFFCCCCCAHFHHAAFFFWRWRRWWWWWVVVVVVVVIVLVLVVLFFFFHRRRRRVVRVVVVLVVLVVV-------G---------R---------A---------Q---------V---------W---------L---------L---------L---------L---------G---------T---------N---------P---------S---------Y---------A---------F---------L---------N--EEEEEEEEEEQNQNNQEQQEQNTNNANNNN-DSHS-SSSV-KKKK-LVVL-IIIT-IIII-FFFF-FFFFSEDEESEEEEGGGGGGDDDD------Y--Y------T--TLIIIILIIIIMMVIMMMMMMVVVVVVSTVSVVVVLVIIVIFFFFFIFFFFGGGGGGGGGGTTTTTTATTTKKHKKKKKKKLIIIIIIIIIVIIIITIIIILILIILLLILKQHQQQQQQQ

KKKKKKKKNKQLLLLLLLLLEDEEQEEQEDGAGGGGGGGGENEQEEEEEERKRRRRRRRRGGGGGGGGGGPPPPPPPPPPDEEEEKEEEEASCSVAACATKLLLLKKLLLFYYYYFFFFYPPPPPPPPPPRPPPPRYPRPFFFMFFFFFFIVVVVIVVIVRKKKKRKRKKNKQQQDNQQKEEEEEEEEEELLLLLLLLLLEEEEEEQEQEHHHHHHH-HHIIIIIII-IILLIIILL-LLYYYYYYY-YYFYFFFFFFFYQQQEQQQQQQEEDEEEEEEESASSSSSSSALLLLLLLLLLQEMQIQQMQEVVIIIVVLVVPS-P-PP-PPKR-R-KK-RRPP-P-PP-PPPP-P-PP-PPVK-K-VV-VKFF-F-FF-FFIL-L-IL-LLKKKKKKKKKKALAAAAAAALQQQQQQQQQQILLLLILLLL

RRRRRRRRRRFLFLLLLLLLRESRRRRRRREEEEEEEEEETKKKKKKKKKSSASTSSSATRRRRKRSRRKQTQTQQTQQQGGGGGGGGGGDDDDDDDDDDKQKKKKKKKKLVLLLLILLLSSIHSSHSSSNMMMMKMKMMNNNNNNNNNQRQRERQEQPRQNQNPQNQQQEQEELEEEELRRRRRRRKRRLRLRLRRRLLKKKKRAKKKKYRYRYRRRYYLLLLLLLLLLTTSTWTTTTWT---------YYYYYYYYYYPPPPPPPSPPAAAASGAGASSSSSSSSKSSKRKPKRRRKKSASASASASSKKKKKNKDKKIWFFFFFFFFLALALEAALLAHAHSSHAAA---N------SASAAAAASVGNGAGAAAGGDDDDDDDDDDSLMMMQLMMMAAAAVAAAAVFFFFFFFFFFAAAAVAAAAAGRGGGGGGDGQEQEEEEEKEAAAAAAAAAA

VVVVVVVVVVKKEEKEEEKKQQEQQHEQQQNNNNNNNNNNAAAATAAATAMMMMMMMMMMLLVVLIVILLTTTTTTTTTTLLYYLYYYLLLLLILILILLSSSTSTTTTS---A------RRRRRKRRRRNNNNGNNNGGTTCCSSCSSSIIPPPPPPPPAAAAAAAAAATTTTLTTTLLRRRRKRRRKRVAGGGGGGGGWYWWWWWWWWVVLLRILVRVTTTTTTTTNTLLLLLLLLLLPPPPPPPPPPLLLLLPILLLLLLLLLLLLIIAPPPPPPDPPPPPPPPPPPQQQQQQQQLQ----V-----LLLLLLLLLLVVVVIVVVIIPPPPPPPSPPKKKKKKKKKKPPPPPPPPPALLLLLILLLLRKKKKKKKKK

GGGGGSGGGGVVVVVVVVVV-G---------I---------N---------V---------G---------V---------E--------LLQLLFLLLLIIIIIII-FIEDDDDDDDDDKKKKKKKKKKFFFFF-FFFFLLLLLLLLLLR-RQ-Q-RRQVVVLVLVVILIIILILIIIIEEEEQEQEEEHHH-H-HHEESSSFSFSFFFGGGGGGGGGGWWWWWWFWWWSSLFNFNFFFTTTTTTTTTTKSKKSKSKKKLLLILIRLLLLLLLLLLLLL------M---RRRRRRRRRRDDDDDDDDGDYYYTYTVLQQRRRRRRRRRRLLLLLLLLLLDNEDDDDEEEFVIFVFVFFFIIIIIIIIIIGGGGSGSGGGL-LLLLLLLLV-MMVMVMMMRRRRRRRRRRRRRTRKRRRRRNRRQRQRRRQQQQQQQQQQPPPAPAPPAAKKKKKKKKKKPPPPPPPPPP

RRRRTRRRKRMMMMMMMMMMSSPPSSSSSPTTTTTTTETTIIIVIIIIILQQQKQQQPQQAV--IVVII-PPPPPPPPPPDDDDDDDDDDSSSSSSSSSATTSSTSSTTSPPHHPHHSPHSTNSSSSSSSDDDDDDDDEDGGGGGGGGGGSSSSSAASSS-----M----PPPPPPPPPPVVVAVVVIVVIIIIIIILIIMMMMMMMMMMLLLLLLLLLLFFFFFFFFFFAAAAAAAAAAIIIVIIIIIIMMMMMMMMMMFFFLFFFFFFLLLLLLLLLLIIIIVIITVIAAAAAAAATADDDNDDDDDNIIIIIIILVIIIIIIILVIILLLMLLLLLLNNNRNNNNNNMGMMMMMFMFTTTTTTTPTT

HHHHYHHHHHRRRRKHRRRKEDEEVEEEEEK-KKKRKK-RD-DEDEDD-DWWLYWWWLWWEEREEEEEEEVILVIVVVVILLLLLHLLLLEDEEEEEEEEIIIIFIVIIFKPKKTKKKPPAAAAAAAAASAAALTATAFAEEEEEEEEEEMMMMMLEMMMLLLLLLLLLLEEDDEDEDEEAAAKAAAVAVHYHHYHHHYYDSDDDDDDSDMMLIMIMSMMKEKKEKKKEEVVVVVVVVVVSSSSSSSSSSAAAARAAAARFFFFFFCFFFWYWWNWWWYNGGGAGGGGGGFFFFYFFFFYEQEEEEEEQSRRRRRRRRRRA-AL-AAA--

PEEPEEEEEETSSSTSSSSSQDEDEDDDDDEEEEEEQEEQII-IIIIIIIDQ-DEQDEQDLLLLLLLLLLNNDSDNNNNNGGGGGGGGGGDDEDDDDDDDLVVLVLVVLVKRRRRRRRERIIIVIVIIVINFNNNFNNYNIIVIIIIIIIIIIIIIIMIIVVIVVVVVVVLLLLLLLLLLLSSLSSSSSSNNNNNNDNNDVIIIIIIILISQNENQSSQSVVVVVVVVVVVVVVVVVVVVFICIVIIIIITTTTTTTTTTDDDDDDDDDDGGGGGGGGGGIIIIIIIIIIVTMEMVIMVIAESESEESEEFFFFFFFFFFACAAAAAAAANKNENNNSNNTTVTVTTITTMMIMMMMMMMDDDDDDEDDE

--G---------C---------S-------GDGGDDDDGGAIAAALALSANYNYYWYYY-GGGGGGGGGGTTTTTKTTVTMMMMMMMMLMPPPPPPPPPPLLLLLLLLLLLLLLLLLLLLNNNNNTHHNNDDDDDDDDDDDDDDDDDDDDIIVVVVVVVVRRSRKRKRRRVCVVVVVVVVGGGGGGGGGGA-AA----AAD-DD----DDG-FG----GGY-YY----NYT-TT----ATH-HH----HHK-KK----KKSSSSRSSTSSYFYYYFYFYYVVVVVIMIIVHSHHHHHHYHFLFFLLLLFFKEEEEEQESEAGAAGGAGVALGRGGAGCGRVLLVLLLLLLQQEQQQQQQEYHYYFYYYYYYYYYYYYYYYLLLLLLLLLLGGGGGGGGGGVCVVCCCCCV

DDDDDDDDDDIVVIVVVIIVSSSSSSSSSSVGSGSGSAVHVILILILVVLYYFFFYFYYFNNENENENNEAASASASAATVIIIIIIIVIYYYYYYYYYYAVAAAVAAAAAGAANGNAAGKKKKKKKKKKDDDDDDDDDEASAAASTAAAVVVAVVVVVVVVVVVVVVVVNNNNN-NNNNGAAAA-AAAAAAAAAAAAAAYYYYCYCYYYAAAAAAAAAADNNNNNNDDNSSSSSSSSSSDSSSSSSSDSIIVIVIVIIVGCGGVCGGGGPPPPAPAPPPAAAASASAAAKKKKKKKKKKNNNNNNNNNNTDTDTDVTTT---------P---------N---------P---------E---------F---------Q---------T---------L---------I---------SII-IIIIII-KK-NKKKKK-DD-DDDDDD-KK-KKKKKK-DD-DDNDDD-HH-HHHHHH-EEEDKEKEEE

DDDDDDDDDDRRRRRRRRHRGGGGGGGGGGTAASSTSSSAFFFFFFFFFFPPPAAPAAAPLLLLLLLLLLKKKMAKKAEKGGGGHGGHGGDNNDDDDDDEAAAAAAAAAATTTTITTSTAAAAAAAAAAAYSSSSYSSSSAIIAASAAAILIIIILPIIIYSYYYYYYYYYYFYYYYYYYGGDGAQGGGGQQQSSQSSSQASAAADAAAAGGGGGGGGGGNNNNNNNNNNQKKKEQKKKK---LL--L-----GG--G--KKKKKKNKKKGGGQQGGQQGLLLLLLLLLLDDDDEDDDDDATAAAAGDASSAASPSSPSCYSYYYYYYYYMMMMMMMMMMMMMAAMAAAM

RRRKRRLRRR-----I---------L---------F---------R---------A---------N---------M---------D---------V---------T---------K---------K---------H---------S----TTTTTVSTTTYYYYFYYFYY--YYY-YY--SSSDASAASSYYYYYYYYYYSYNNNSNNNS--VV-VVVV---LLL-L-----AQQ-Q------YY--------RR-------III-I---LLLLLLLLLLTTTTTTTTTAQQQQQQQQQQAKSSSSSSSKARHHHHHHHRMM-MMMMMMMVLSSSVTAVVAAGAAGAGGAEETTTETEEEKKPPPKPPRKNDDDDDDDDDTMIIIIIIIMPPVVVPVVPPYYYYYYYYYYNNHHHNHQNNVIVVVIVVIVQQKKKQKKEQTTSTSTTTTTPPTTIPTTTPTTDDDTDDDTRRRRRRRRRRGGGGGGGGGG--I-------NGTTTNTTVG--NNN-N-----GGG-G-----TTT-T-----LLL-L-----MMI-M-----GGG-G-----LLL-L---TTVTTTTTTTTTTTTTTTTTLLLLLLLLVLPEEEEEEEDEAAASAAAASATVVVVTVVVVQQQQQQQKQQ

KKRRRRKKKRMSMMMMMMMMFFFFFFFFFFVVIIIIIIIIGGGGGGGGGGVV-V-VV-VVWWWWWWWSWWRRRKRRRRRRLLLLLLLLLLVVPSPSPPPPYYAYAYYYYYEKEEEEEEEEPPPPPPPPPPGGGGGGGGGGNNNNNSNNNNRRPVPVRARVDDVAVSSVSITTTTTTTTTNEE-E-EEEEEIIFIFIILVLAAS-S-AAASNNH-H-HHHHSSRGGGTGTGMLILILLILIPPPPPPPPPPKKKKKKKKRKDDDDDDTDTDDDDDDEDDDDGGGGGGGGGGLLLILVLLLLLLVVVVVVVVVVTVTVVSVTIIVIIIIIIINDDNNNNNNNNNNNNYNNNNVVVVVVVLVVVVFFFILILF

RRRRLRRRRRKKKKKKKKKKSSNSSSSSNNKVGIVAGIGGDEEEEEDEEELLLILLLILLLLVLLLLLVVRRRRRRKRRRTTTTTTTTTTEGDDDDDDDDAAAVAAAVAAEPPPPPPPPPIVIIIIIIII--------T---------F---------I---------E---------I---------R---------T-LLLLLLLLLLLFLFFLLFLLQQKEEQQERRFFFFFFFFFFLLLLLLLLTQVVTVVVVVVVFYIYYYFYIIFFFLLFFLFFACACCCASAALLLLLLLLLLGGFGGGGGFFLLLLLLLLLLLFLFFFLFLLSSSSSSSSTTMMMMMMMKMMRKRKDKRKRRDEDEEEDEDDLILIIILILLDGDGGGDGDDRRRRRRRRRRFYYYYYYYYYSASAAASASSDDEDDSDDEEDDDEDDDEDDSSSDEASDSS

IIIVIMIMKLPPPPPPPPPPGGGGGGGCGGVVLFVVVIVVDEEDDEEEDAEEEHEEEEEEEEEEEEEEEEVVIVVVVVVVKKKKKKKKKKEEEEEEEEEEVFFVFFFFVFAAAAAAAAAANGNNNGNGNSRRRRRRRRRRSSSSSSSFSSR--KK---R-YYYYYYYYYYILIIILILILGSGGEGGGGS-V---------A---------Q---------L---------P---------A---------M---------D---------A---------R---------Q---------F---------E---------P---------T---------L---------G---------P---------D---------F---------S---------I---------R---------P---------R---------L---------K---------V---------T---------V---------R---------I---------D---------A---------Y---------Y--------EDDEEEDDEDLFLLLRLLLFILRIIIIIIIVVVVVVVVVVMVMMMMFLMVIVVIIVVVIVQRQQQQQQQRLLLLLMLLLLEEEEEEEEEELLLLLLLLLLKQKKKKKKKQHHHQH-H-HHEEEDEENEDEIIVIIIIIIINCNNNNNNNCAQEEEDDDEQVAAVVAAAMAFFYFFFFFFFDEDDDDDDDEEDD-RDDDDDLLL-LLLLILLIL-LLLLLI--------T----T----T----A----V----L----L-

YYYYYYYYYY-VV-TV-V-VEEEEKEEEEEPPDPPPPPPPRWWRWWRWRWAASASSASAGEQEEEEEEEETTLTLLTLTTAAAAAAAAAAIIVIVVLVLIQQQQQQQQHPKKKKKKKKKKI-IIIIIIIIRRNRNNRNRRVMLMMIMMMMVAAVAAVSVVGGGGGGGGGGIIIIIIIIFIGGGGGGGGGGGGGGGGGGGGLLVLLLLLLLNNQNQQSQNNQQQQQMQQQQYYYYYY-Y-YNNNNND-N-NGGAGGG-G-GTTTSTT-T-TIIIIIIIIIVAGGSGGSGSGWWWWWWLWIWIIIIIIIIIIAAAAAPAAAAHHHHHRHHHHPPPPPSPPPPTTESEETESTDDDGDDGDGDSTSSSSTTSAFFFFIYFIFFYYYYYYYYYYLLL-YL-L-L

SGGSGRSRSSTSSSSTSTSSFFFFFFFFFFAHHHHAAAHRTTTITTTTITGGGGGGGWGGNNNNKNNNNNQQQQQQQQQQGGGGGGGGGGVVVVVVVVVVDDDDDDDDDDIIVLICICLLNNNNDSNNNNSSSSSSSSSSQQKQQQQQ-QIVVIVIIL-IGGGGGGGGGGHHHHHHHHHHEEEEEEQEEEAAASAAAASA---Q----R----Q----E----A----A----P----P----E----E-DLMMMEAEMM------V---IIIIIIIIVIYYYYYYYYYFEEEEEEEEEEKIIIIKKKIIPPPPPPPPPPHHYHYHHKHHVVVVVVVVVLKKKKKKKKKKKKKKKKKKKKTTTSTTTTTTDDDNDDDDDDFTSYTFFFFF

YYYYYYYYYYVLLIVLILIVNQQNQQNQNNFLLLFMLLFFAVVATVVVYVLLLLLLRLLLLVLLLLLVLLNQQSNQNPNNTMMAMIALMAEEEEEKEEEESSSTSSSSSSVAAVVAVAVVAAAAAAAAAALMLLRLLLRLTSSTTSNSTTGASGGSNTGGILMVIIILIIVAAAA-AAAAEEEDEEEEEEKKKTKKKKKKDDDEDDDDDENNPNNPNNNNVVVILVIVLIGAGGGGGC-GAAAAAAAAAAYYYYYYYYYYNNNNNNNNKNSSSSAA-STSEEEEEE-EEEYWYYYY-WYFRYKRRR-RRRSTSSSS-TSSRRRKRRRRRRDDDDEDDDDDEAAEEAEAEE-------M--

------L---RAAAAAAVAATTTTFTTTSF----R----R----I----I----N----N----D----D----E----E----L----L----V----V----A----A----W----W----K----K----V----M----T----T----D----D----N----N----E----E----E----E----K----K----D----D----A----T----E----D----K----K----G----G----K----R----L----L----R----R----Q----R----H----H----S----S----G----AAEEEETEEEEFFFFFFYFFFGGAGGGGGGGMMMMMQMMMLDDDDDDDDSDQEQQQQQQAQSSSSSSTSSSEEEEEEEEEEPPPPGGPPPG---S---------W---------E---------D------EEKEEEEEEEIVILIIIIIILLLLLLLLLLMMDMGGDMDGEEDEEEEEDEFMYFFFFFFFKKKKKKKKKKVVVVVVVVVILLVLLLLLLLKKKKKKKKKELLLLLLLLLLLLILLLVLILPPPPPPPPPPDDDDDDDDDDWWFFFFFWFFGGGGGGGGGGKEKKKKSKKKRRRRRRRRRRTTTTTTTTTTSSSSSSSSSSQQRQKKRQRKAARKKKKKKK----AP---A----NN---N----II---I----DD---D----RR---R----II---L----GG---G----AV---A----VV---V----LL---L----TN---T----GG---G----QQ---Q----EN---G----SS---S----KK---K----AA---S----SS---S----GG---G----GG---G----VV---V----DE---D----QQ---Q----NN---N----AA---A----NN---N----II---I----YY---Y----MM---M----VV---V----NN---N----DE---D----QQ---Q----LM---L----II---I----II---IETQQQQQEQQ-KKKEKKKKE-FFFFFFFFV-SASAAASAA-GGGGGGGGG-NANNNANAN-YYYYYYYYYLLLLLLLLLLGNNNNNNNNN

NNSNSNSNNSLLLLL-LLLLRRRRK-RRKKKKKKD-KKNKSSYAY-YAYYLLLLL-LLVLYYYFY-YYYYPPPPPPPPPPAAVAVAVEVVAAAAAAAAAAQQQQQQQQQQRRKRKRKRKKRRRRRRRRRRYYYYYYYYYHAAGAGAGAGGGGNGGGNGGGDDDDDDDDDDAAATAAAAAASSSSSSSSSSQQQMQMEMQQNNNNNNNNNNTTTTSTTTSVVVVVTVVVTVFFFFFFFFFFTTTTTTKTTQFLLLLLLLLLLLLLLLLLILHHSDHDSDHHIIIIIIIMIVLLLLLLLLFLFFFFFFFFFFVSAVVVAVVAYYYYYYYYYYHHQHHHRHHHFFFFFLFFFFNNSTTTSTTTRRRKKRRKKKPPPKPPPPSP-------Y--PPPPPEPDPPGGGGGGGGGGEEEEEEEEEELLLLLLLLLLLLLLLILLLL---------R---------P

NDNNSNNNNNSSSSSSSSTSLLLLLLLLLQFFFFFFFFFFMIVITIITIIDDDDDDDDDDLLLILLLLLLRRRRRRRRRRAAAAAAAAAAFFFFFFFFLVLLIFIFLIIILLLMLLLLLLEEEEEEDEEEVVVVVVVVVVTVAVVVVLTTSSSNSSSSSSVVVVVIVVVVNDEDEDDESSLLLLMLLMLLRKKKKKKRKKEEEEEEEEEEIIIIIIIIIISSSVKGSDTTKKTKKKKKSSVVVVVVIVVVLSTTTTSTAATTSSSDTSTTAGGGGGGGAEFFFFFFFFFFEEEEEEEEEEEEEEEEEEQQTTTTTTTTTTLLCLLLLLLLTTKSNLTKTTIIIIVIIVILDDNDDDDDDDVVMVVVVVVVGGGGGGGGGGDDDDDDDDDD

IIIIVIIIIILLLLLLLLLLEEEEEEEEEESSTTETTTSSGGGGGSGGGGTTTTTTTKTTA-A--AAAAAP-P--SPSPPE-E--PPPEEG-D--DDDGGQ-Q--QQQQQI-I--IIIIIA-A--AAAANIQQQQQQQIIAAAAAAAAAA-AAAAAAAAA-GGGGGGGVCTNNNNGGGAAAAAAAEAAASSSKNSNNNSSCCCCCCCCCCPAPHPPPPPKRRKRRRCRRRPPPPPPPPFPDDDDDDDDDDNNNNNNTNNNILILLIIIIIRKRRIRRRRRRRRRRRRRRRVVVVVVVVVVAAAAAAAAAGDDDDDDDDDDNQQQQQQQSS

PPPPPPPPPPKNNKKKKNKKAAAAAAASAAYFFYYYYFYFDDDDDDDDDDWWWWWWWWWWRRRRYRRRY-AAAAAGAVA-LLLMLLLLLL--G----A----Q----E--AAAAAAAAAAIMMVMMIYMMRRRRKRRRKKGHQGHGGHHHFFFFFFFFFFAAAAAAAAAAL--L-AL---E--E-EE----LL-L--LLL-AA-A--AAA-VV-V--VVV----H---HH----E---EE----E---EE----T----T----L----L----P----P----E----E----H---HH----A---AA----P---AP----V---II----R---RR----E---EE----A---CM----C---CC----H---HH----G---GG----V---VV----D---DD----V---VV

DDDDDDSDDDAMMHMMMMMMDDDDDDDDDDNNDANNNNALASPAPSGGAQEEAEEEDEEEPPPPPPPPPPLLLLLLILLLFWFFFFFFFFTTTTTTTTTTGGGGGGGGGGPPPPPPPSPPLLLLLLLLAKSYEYEFYYYYVVVIVVVVTVPPPPPPPPPPYYYYYYYYYYFFFYFFMMYYEEEEEEEEERNDNSNDNNHERRRSRRRRSSAAAALAAALAQQNQNNQVQQHHHDHHHHHHGGGDGGGGDDEEEEEEEEEEIIIIVVIIVVGGGGGGGGGGDDDDDDDDDDAAGGGGAAGGVVVVVVVVIIFFFLFFFFLLEEEEEEEEEEAAGAGGAAAANNKNKKNNNNSSSTSSSSSSLLLLLLLLLLAAAAAAAQAAVIVVVVVVVIIIAVVVIILVSSGSGGSSSSYYYYYYYYYYEEQQRQQQQQ

AAAAAAAAASSIVLLVLLLLGGGGGGGGGGLLLLLLLLLLQHQQQQQQQQTQTTQSIITTSTRRTRSSRTDTTTTTDDTTLILFILLLLDKKRKKKKKKKFFFFFFFFFFFLFFLFFFFFNKDNKDNNNSEEEEEEKENEVVVVIVVVVVLSHHLHLLHLAAAAAAEAAAQKKQKKKKKKEEQEEQEEQELVLLLLLLLLQEEEEEALQQYYYYYYRRYYGGGGGGGGGGVVVVVVVIVVFFFFFFYFFLDDDDDDDDDDTTTTTTATTTNKENNENNN-QQQQQQQDQ-QQQEKQQQQQRRRRRRRRKKLLLLLLFFLLLLLLLLLLLLLLLLLLLALLSTTTTTSSVTQNDDSDDDDDPQQQMQPPQQESAEEAEEAERLLLLLRRLRLALLLLLLLL

SSSTSNAASTIVIIIIVVVIYYYW----MWPPPR----RRLLLL----LLPPPP----PPLLLI----IIMMMM----MMSSSS----SSGGRG----GDDDDD----DDPKPP----PPLVLL----LLGGGG----GGAEAA----AAPPPP----PPLLLM----MMGGGGGGGGGARRESRKKKKSQQQQQQEQQKLLLIIVIIIIFFFFFFFFMFSSSSSSSSNSDDDDDNDDDDWWWWEWWWWWRRRRKRRRRRPPPPPPPPPPQKKRKKKKKKAAAAAAAAAATTTLMMIMLLEEEDEEEEDQTKRRDNNNRRLLLLLLLLLLRRRRRRRRRRKKKKKKGKKKLLLLLLLLVLHHHHPHHHHHMMMMMMMMMMTKKRKKKHRRSSEENEEEEEAAAGSSSTGG

---------Q---------Y---------V---------L---------R---------K---------I---------G---------R---------K---------L---------L---------Q---------D---------S---------TGGEGGGGGGGLLLLLLVLLLDDKDDKDQKTVVVTVKVVVVPPAPPAPAAPNGNNNNNNNNAASAAAAAAAYYFYYYYFFYFFYFFFFFFYTTTTTTTTTTMMMMMMMMMMNNNNNNNNNNTTSTTTTSSTEEEEEEEETEKKKKKKNKKKSSSSASSSDSKKTKKQKKVKQQKQQNQKKQTYHTTHYHHTGGGGGGGGGGVAAVPAAAAPDNDDDDDDDDEKKKKKKKKKLLLLLLLLLLDDDDDDDDDDFFFFFFFFFFASTAATAETATTTTTTSTITFFFFFFYFFFEEEEEEEEEEALLIVLLLLIAAAAAAAAAAASSSASSSSAVILVVIILLTA---A----AITTIITITTI

STSLTTIITTHHKHKKHHKKNNNNNNNNNNDDEDEEDDPEPPPPPPPPSPGGGGGGGGGGTTSTTTATTTIVIVVVVVVVVVMVLLVPLLWWWWWFWWWW----S---S-----Y---Y-----A---A-----G---G-----N---N-----Y---Y-----L---L-----P---P-----F---F-----I---I-----Q---Q-----A---A-----E---E-----E---E-----T---T-----Y---Y-YYFYF-YYL-HHQQLQHQLQLQKQKEQQKKRRRRRRQRVRAASATTAATTTRSRKAKRSSGGGGGGGGGGEEEEEEEEEERRRRRKRRRRGGGGGGGGGGHNQNQANNRQRRRRRRRRRRPPPPPPPPPPKKKKKKKKKKIIVILIIILFYYYYYYYYYYRRRNQRRRRRGGGGGGGGGA--------S-G-G-GG--GGRRRIRRRRKRHHHYHHYYHHGGGGGGGGGGRKKKKKKKKKYFFYFFYYFFAAAASAAAAS

TTTATTTTTTNDNDDDNDNDMMMMMMMMMMIKIKKKIKIKAAAGAGAGAGKKKKKKKKKKEEEMEEEMEMVAQAAAAAVALILLKLLLLLGGGGGGGGGAHCCCCCYCYCARSERRAEAESASAASESSSSPPPPPPPSPDDDDDDDDDDWWWWWWWCWC-F--------TLN-I-T-T-DNNNNNNNNNVIVVIVVIVIHHHHHHHHHHGAGGGGGGGGAAAAAAAAAAGGGGGGGGGGSSSSSSSASSNNNNNNNNNNGGGGGGGGGGP-----A-P-K-----K-K-L-----L-L-F-----F-F-E-----E-E-Q-----Q-Q-P-----P-P-A-----A-A-I-----I-I-K-----K-K-F-----F-F-E-----S-E-S-----S-A-G-----G-G-R-----R-R-K-----K-K-PPLPPPPPPPRRRRRRNRRRNQNNQNDNNNAAAVAVAVAVRKRRKRRRRRVVVIVVLIVIVVVVVVVVVVWFLFFFWFWFRSSTSSSTST

SSSSSSSSSSPDPPPPPPPPAAIIAIAAAAFFFFFFSSFF----I-----GGGGGGGGGGTMQMTMMMTMPPPPPPPPPPEEEEEEEEEEEEEEEEEEEESSTSSNSSSSNSTTSTTTSTLLLLLLLLLLMLFMWLMMMMFFRRFRFFFFFFFFFFFFFFFFAAFAAAFATNSATATCTTKKKKKKKKKKIVVIIVIIIIDNANDANNNNKKKKKKKKKKFFFFFFFFFFKKKKKKKKKKLLMILILLLLQIIIMIIIMIQHHKQHHHQHYYYYYYYYYYWWWWWWWWWWAAAAAAAAAAQQHHQHQQQQVVVVVVAVVVLLLLLLLLLLNTDDNDTTTTRKKKRKKKKKTTTTTTTTTTLLLLLLLLFLLLAMLMLLLLAAVAAVAAAA

ASASSSSTSSAATVAYSAVVAAAIGGGPVIAAAAAAAVAAFFFFFFFFFFIIIIIVIIIIATTTTTTTTTEEEEEEEEEE---A------FLFIFYYLLLPPPPPPPPPPIIIIIIIIIIIIIRIVIIVVKKKKKKKKKKLLLLLLMLLLNTNTNNNTTTYYYYYYYFYYVVVLVVVVLLKRKRQQQRRRTTTNTTTTSSLQLLLLISFLLQLQLHLQKQKRRRRNRRRRSSSNSSDSSSHQQQQMMQKQMIMIIIIIIIPPPPPPPPPPLLLLLLLLLLGGGGGGGGGGEEEEEEEEEETATVTATSVTYYYLYYYYLIYYYYYYYYYYNNNNNNNNNN

LLLLLLIILLYYYYIYYYYYRRRRRRKKRREEEEEEEEEELLVLLVLLLLEEDDDDDDDDNNNNNNHHN-LLLLLLLLL-SSSSSSSSSS--------P-SSSSSSAASSIIIIIIILIIPPPPPSPPPPMMIIIVIIIICCCCCCCSCCVVVVVVVVVVPPPPPPPPPPAARRKRAARRTTHHHTSSHHRRRRRRRRQRGGGGGGGGGGPPPPPPPPPPYYYYFYYYYYQQRQQRMMQQIIIVVIIVIILLLLLLLLLLTTTTTTTTTTGGSGGSGGGGSSSLSSSSSSEEQEEKEEQQEENDEDEEEEDDDDDDDDDDLLCCCCAFCCAVVVVVIIVVSASSSSSSSSSVNSSSSSSSRRRRRRRRRRQQQQQQAAQQVVVVVRVVVVGGGGGGGGGGVVVACVIIVV

LLMLLLMLLLEESEEESEEENNNNHHNHHHEDDDEED-EDTTTTASTSTT-YYYYYYYYYDDDDDDDDDDKKKTKK-KKKHHYYYYYYYYDDDDDDDDDDNSAASSAASSINLIIIIIIVILILLLILLLGGGGGGGGGGEEKEEEEEEEDEQKEEQEEEFFIIIIIIIIDDDDEDDDEDTTSSTTSTTTAAAAAATAAAGSNSSSNSSSPPPPPPPPPPYYSYYYYYYYDDDDDDDDDD-LILVVLVVVAAAAAASAAASSSSSSSKSSLIFIIIIVIIEEEEEEEEEEVVIIVVITVV--------D---------Y---------V---------G---------Q---------Q---------L---------G---------E---------L---------K---------Q---------N---------F---------L-TTTTTTKTTTRRRRRKRKRR

DDDDDDDDDDPPPPPP-PPPVVVVVVVVVVMMMMMMMMMMLLLLVLLLMLTTTNTTTTTQIIIIMIIILIQQQQQQQQQQFFFFFIFFFFTTAEATTTAEGGGGGGGGGGNNNSNNNNNSKKRKRKKKRKGGGGGGGGGGIIIIIIIVIIMMMMLMMMLMMMMMMMIMMLDDDDDDDDDDTTTTTTTATTRRRRRRRRRR---I-----I---K-----K---V-----E---T-----T---H-----HLILLILLLILLLLLLLLLLLSDSASSSDSAEEEEEEEEEEIIIVIIIIIVDDDDDDDDDDPPPPPPPPPPMMMI-MMMILHHDHNHHHNHRRRRRRRRRRSSPSTSSCTSRRRKRQRRRKKKKAKKSKKAAAASAAAAAAGGGGGGGGGGDDDDDDDDDDKKKKKKKKKKKRQQQKERQQLVLLLLL-LLNNNNNNN-NNLLFL-LFLLLYYFYFYYYFYAAAAAAAAAATTAAACTTAA

SSASSASSASSNSSNSSSSSASAASASSVACCCCCCCCSCEAVAAVAAAALPMLPMPLLLIVIIVIIVVIFFIFFIFFIFNNNNNNNNGNDDDDDDDDDDKKKKKKKKKRSSSSSSSSSDLLLLLLLLLLILIILFQIIIAAAAVAAAPASSSSSASSSSLLLLLLLYLL--A--A--A-AAAAAAAAAAHHHRHHHHHKYYYYYYYYYYVVVVVVVVVVAAAFAAAAAWSASSASTSASFFFFFLFFFFSTTTTTTTTTNT-TT-TT-TNH-NH-NN-NCA-EA-AA-ILM-LM-MM-LLL-LL-LL-LTC-TC-CC-TDE-EE-QQ-EMM-TM-MM-MVV-VV-VI-VRG-RG-GG-RHH-HH-HH-HDD-DD-DD-DTT-TT-AT-TEE-EE-EE-EKK-KK-KK-K

KKKKKKKKKKHNHHHHNHNHASEAKAAAAAIMIIVIMVMIKKKKKKKKKKAAAAAAAAAASGGGGSGGGSRRRRRRRRRRNPPSPNPSPNTTTTTTTTTTGGGGAGGGGGYSSYSYSYSYAAAAAAAGAAAEAAAAEAEAIIIIIIIIIINQQQQNQQQQKKKKKKKKKKVIIIIIIIFIIFIIIIFVFIFFFFYFFFFFNHNYNNHNHNASSSSSSSSSITTTTTTTTTKRTRRKRKRKKHKRHKHKHKPPPPPPPPPPAAAAAAAAAAGVAGVGVGVGDNNDNDKDNDGGGGGGGGGGIVVIVIVIV-GGGGGGGGG-FFFFFFFFF-L----L----EEEEEEEEE-PPPPPPPPP-SDDDDDDDD-YHHHNHHHHH

G---GGG-GGD---DDD-DDP---PPP-PPT---TTT-TTK---QRR-RRF---FFF-FFT---TVV-VVC---CCC-CCL---LLL-LLV---VVV-VVD---DDD-DEP---PPP-PPF---FFY-FFT---TTT-TPI---VVV-VVT---TTT-TTF---FFF-FFE---EEE-DEC---CCS-CCL---LLL-LLQAAAQQQAEESSSSSSASSSTTTTTTTTTADDDDDDDDDDVVIVVVLIVVVVVVVVVVVVIIIIIIIIIISSSSSSSSAAKSSSKTTSTTGHGKGGGGGGEEEEEEEDEEDDDDDDDDDDNGNGNGGNGGENEQEEEEEEVVIVVVIIII

NNNNNNNNNSYYYYYYHYYYARRARVAAAALLLQLLLQLLAAAAAAAAAANNNSNSNSSPAAVSVSASSTDDDEDEDEEEIIILILLLLLVAVAVVVAVVLLLLLLLLLLHSSTSTHTSTKCCRCRRRRR---A---------E---------A---------K------RRRQRRRRRRYFFFFFYFFYIIIVIVVVVVYYYYYYYYYHTSDEDETEEESSSSSSSSSSVVVVVVVVVVDEEDEDDDDDKRRRRRRRKKEEEEEEEEEEPPPPPPPPPPTTTTTTTTMTEEEEEEEEEERRRRRRRRRRNKKRKRRRKREESEEEEEEEKKKKKKKKKKIILVVIIVVIYYYFYFYFFFSSSTASSSSSNNNNNNNNNNFFFFFFFFFFAAKAKAAEAA

QQQQQQQQQQWWWWWWWGWWKKKKKKKGKKGGSAGGGGGGIIIIIIIIILQSHQQQHQHQQQQQQQQQQQLLLLLLLLLLGEEEEEEEEEEFFFHFFFFFHHHHHHHHHH------G---------G---------F---------G---AAAAAAACACSAESEAEEEELLVLLFVLQLLLLLLFLLLLYFFFFFYFYFKQKAKARKKKGGGNGGGGGGPPPPPPSPSPTTTTTTTTTTDDSDDDSDSDIVIVIVIIIIGEEEEEDEQEDPNDDDQDQDSSSSSSSSSSRRSRRRKRRRDDDDDDEDEDVVVVVVIVIVILIIVIVVVVEEEQEEKEEEQERERERRRSRRHSNRHNHNVLILVLYVYVLLLLLLLLLLTAAAAATASAMLFLRLMMMM

LLLLLLLLLLLLLLFLLLLLVAAAAAAAAATTTTTTTTNTVVVIVIVIVVIIIIIIIFIINDDNNNDKDDIALIIILIAMVVVVVVVVVVYFFFFFYFFFKQQKEKQKQKLMMLLLMLMLATAVVVTATAEEEEEEEEEELLFLMLFLLLAASAAAAAAAEEEEEEEEEEKERKKKEKERLLLIMILLLFELLEEELVLVILLVVVLLLLEEEEEEEEEESNNSSSDNNNQQQQQQRKKQYFYYYYYYFYAAASSSAAAPRIKQRRKRIQMLLAAMLLLLPPPSPSPPPPNDENNDENENLLLLYLLLLLLFLLLLFLFLPPPPPPPPPPSNNSSSNSNSQRQQRQKQRNFFFFFFYYFFGDDGGGDDDD

TSSTSTTTSTDDDDDDDDDDIFFFFIIIFIAAARAAAAAAGGGDGGGGGG-----V---------I---------S---------C---------I---------R---------P---------I---------C---------A---------F---------M---------A---------S---------L---------F---------L---------V---------N----TNNNNNNNNNEEEEEEEEEEIVIIIIIVIIETEEEEQQSQNDNNNKNNDKRRRRRRRKRKIATTTTTTATQQQQQQQQQQRIVVVVRRVRNNDNNTSNNSGGGGGGGGGGQQQQQQQQQQYYFYYYYYYYVVVVVVVVVVLFFFYFLLFLMMMMMMMMMMYLLLLYYYLYQQQQQQQQQQIVVIVIFIVFHHHHRHRRHRFFFIFFFFFFVVFTLVVVVVMMMMMMLPMITTTTTTTTTSKEKKKKKKKKAKKKKKKKKKIIIICIIIII--------L---------E-AQQQQKQEQQAIIVVVAAIASSSSASSSSSFYYYYFFFYFASAAAAAASAKAKKRQKKKKQNQQQQQQQQTNTTTTTTNT

HQHQQHQHQQDDDDNDNDDDNNNGNNNNNNNASSANASSDIIIVIIVIIITSTSSTSTVTWWWWWWWWWWGGGGGGGGGGLIIIIIIIIIGGGGGGGGGGLLLLLLLLLLTTTTTTTTQTFFFFFFFFFIIILILIILIIEKEEQEEEEEGDDDDGNDDDPPPPPPPPPPVVIVVVVIVVRRRRRRRRRREAAAAEAAAARRRRVRVRHREEEEEEEEEAVVVLVVVVVVYYYHYYYVYYDDDDDNHDDKLLLLLLFLLLKKKKKKEKKKVVVVVVVVVVVVVVVVVVVVNKNRKNKHNNPPPPPPPPPPIIIIIIIIIIGGNGGGGNGGLLLLLLLLLDKRKKKKKEKKYYYYYYYYYY

IIFFFFIFFFLLLLLFLFLLPPPPPPAPPPPPTPTTPTPTAAAAAGAAAAAAAAAAAAAAIIIIVIIIIITTTTTTTTTTIIIIITIIIIIIIVIVIVVIVVVIVVVVAVIIIIIVIIIIGGGEGGGGEGLLSMSLLLLSLLLLLALAMLHHHHNHHHHQII-I--I-I-QQ-Q--Q-Q-LL-L--L-L-EE-E--E-E-LL-L--L-L-NH-N--N-N-KE-K--K-K-AA-V--A-V-RR-R--R-R-VV-V--L-V-RR-R--R-R-LL-I--L-I-NN-N--N-N-AA-A--A-A-TT-T--T-T-KK-K--K-K-LM-L--L-L-YY-F--Y-F-DD-D--D-D-

NLLSLSLSLLSSTSVSSSSVRRRRRRKRRRVVVIVVVVVVPPPPPPPPPPIIIIIIIIIINNNNSNNNNNEEAEEEEEEEEEDEDEDEEDRKSKRKRKKRRSARAKARSALAILIIIIAISSTSTTTTSSSAASAAATARNNNNNNNTNNKKVKVKVKKVLYYFYFYFFYEEEEEEEEEEVIVVLVVVIVDDDDDDDDDDGGGGGGGGGGTTTTTTTTTEGGGGGGGGGGFLLLLFLFLLLLLLLLLLLLAAFAFAFAAFKKKKKKKKKKLVVVVVVVVVKKRKSKKKKKIIIILIIIIFEEQEQEQENQTTTSATTTTTEEEEEEEEEESSSSSGSSSSSSSSSSKSSEIIIIVIIIIV

VVVVVVVVVVDDDDDDDDDDWWWWWWWWWWEEEEEEEEEEAASGSGSGSSSSSSSSQSSSMMNMNMNNNDPPPPPPPPPPDDDDDNDDDDIIIIIIIIIIGGGGGGGGGGDDGKDDGDGD-A---------L---------A---------F--------CCCCCCCCVCSSSRSSSSSSAAAAAAAAAQYYYYYYYYYYQHRHRHRHRRLLLLLLLLLLNN--------CC--------GT--------LL--------LL--------RR--------HH--------ST--------LL--------EE--------LL--------DN--------GG--------SS--------SS--------SA--------AA--------RR--------PP--------SS--------AA--------KK--------GGGGGGGGGGPPPPSPPPPPGGGDGGGGGAVVVVVVVVVVLLLLLLLLLLDDDDDDDDDDYYETTTHTDDTTCTCTCTCCPPEPPPEPEPRRRRRRRRRRAADASAGSDGKARKKKRKRRYYFFFFFLLFGGGGGGGGGGSSGSGSGGGGKKQRKRQKQKGGGGGTGGGGLLFLFLFFSFAATLVLTVKT

EEEEEEEEEEATAAATAATAGGGGGGGGGGP-VVPPVPPPP---------S---------Y---------Y---------L---------I---------G---------V---------E---------I---------D---------T---------E---------F---------K---------E---------N---------E---------V---------I---------V---------H---------T-SSSASTAGH-YYYYYYYYS-DDDDDDDDI-VVVIVIIIP-PPPPPPPPM-EEEMEATML-LLLLLLLLTTTTTTTVTTIIIIIIVIIIGGGGGGGGGGPKPPPKPPKKKDEEDDEKDDAAAAATAATAKKKKKKKSKKMLLLLLLMLLCHCCCHCCFHSSGSSSGSSSTQTTTTTTTTQQQQQQQQLQVVVVVVIVVVVCVCCCVVCCVVVVVTVVTRIVIIIIIVIIKNKKKNKKNKEEEEEGEEGEAAAAAAAASAPPPPPPPPPPEDNNNDNEDDEEEEEEE-EELLLLLLL-LLKKKKKKK-KKFYFFYYF-YY

VVAIVVVVVVSSSASSSSSSNNNNNNNNNNLMLLLLLMLMIIIIIIIIIIAGAAAAASASLIVIIIIIIIEEDEEEEEEEHHNNHHHHNHLLVVLVLLVL-F-----F-F-K-----K-KILLLLLLLLLLLLLLLLLLLRRRRRRRRRRARAAAAAALAR-RR--R-R-V-VV--V-V-D-DD--D-D-I-II--I-I-D-DD--D-D-G-GG--G-G-P-PP--P-P-I-II--I-I-I-MV--M-M-T-TT--T-T-F-FF--F-F-N-NN--N-N-P-PP--P-P-W-GG--W-G-K-AA--K-A-V-VV--V-V----V------V-VL--V-L-P-PP--A-P-V-VV--V-V-L-LL--L-L-T-GD--D-D-P-P---P-P-EEE-EEEAEANDD-DDDDDDEEEEEEQEDELLMMLLMLML

EKEEEKEEEEFFFFFFFFFFQEEQYEEKEQHHHHHHHHHHQQRQQQRQRQDDDDDDDDDDYYYYYYYYFYTTCTTTTTTTGGGGGGGGGGNNTNNNHNHNYYFEFYFFFSKANKRSNKNKMMMMMMMMMMGGDGGGDGEGAAAAAVAAEADEEEEEEEEDLLLLVLLILLNENNNNNNNNTTTTTTTTTTSASSSSSSSSDDDDDDDDDDGGGGGGGGGGNNNNNNNNNNNEQNNEQNQNVLILQLIQILHNNNGNNGNDGGGGGGGGGGQQRQQQQQQQRKQKKKQKKKPPPPPPPPPP-----Q----NNNNNNNNNNAAAVVSAVAAEEEEEEEEEEYYYYYYYYYYEEDEEEEEEEAAAAAAAAAAVIVIVVVVVVQKKKRKKKREIVIIIIIIII

STAASSSFSSIIFFFFIFIFVVVIVVVIVVVTVVTVVVVVIIHIHIVIII----V---------G-----TTTTTTTTTSEEEEEEEEEETTNTNNTTTNAAAATAAAAALLVITILIMITTSTSSTTTSEEEEEETETEPPLLLLLLLLVVILIIVLVINNLNLLNNNLEDQDQEEGDEIIVIVIVIIILLLLLLLLLILLMLMMLLLMEEEEEEEEEEKKPPPPKPKPLFLLLLELELFFFFFFYFYFRRRRRRRRRRHHEHHHHHHHDDKKKKKKKKPPVPVPPPPPDDDDDDDDDDLLLLLLLLILHHILIIILITTTTTTDTTTDKKRKSRRKKRLLILIIGLGITT--------AA--------AA--------YYYYYYYYYY

YYYYYYYYYYKNKKKKKKKK-------A---------K---------E---------V---------F---------V---------A---------T---------R---------E---------S---------T---------L---------R---------T---------T---------K---------I---------K---------E---------Q---------L---------T---------D---------Q---------T---------L---------E---------K---------S---------P---------K---------P---------K---------L---------Q---------V---------Q---------A---------E---------D---------D---------F---------A--LLLLLLLFLLPPPPPPPPPPIIIIIIIVIIRRRKRRRKRRAAAAAAAAAEDDEDDDDDDDLLLLIIILIIRRRRRRRRRRIIILIIILIIDDDDDNDDEDLIILLLLLILIFFFILFFVITGGGTRRGTTNNNNNNNNNNKKKKKKKKKKKRKKKKKKKKIIIIIIIILIRRRRRRRRRKMMMMMMMMMMTSSSTTTSTTCCCCCCCCCCRRRRRKRRRRVAAAAAGAVARRREKRRRRRAPPPAPPKAAMMMMMMMMMMITTTVVVTVIATTTSSSTSSLLLLLLVLLLAAAAAAAAAANNNNNNNNNN

TTTTTTTTTTAAAMAMAAMAVFFVFIVFIVVAAVAIVVIVDNEDNDGNDDAAALAFAALALLLLLLLMLLVVVKVAVVAVDDDADDEDDDSPPPPPPPPYRRERRRRRRR-AA-A--A--SNSSSGAASSWWWWLWWWWWRHKRRRRSRRQQQQQQQQQQHYYHYHHYHHLLLLLLLLLLFWWIWFFFFFEKKEEEEEEEGGGGGGGGGGDNNNNDNNNNGDDGDGGGGGNQQNQNNQNGLAALALLALLRRRRRRRRRRDEEEEEDDEDTTTTTATTATVMMVMVMMVVGGGGGGGGGGDDDDDEDDDDAAAASA-SAA

EQQHQQQQEQDSSSSGSSSSQNQEEEKEIIVVVVVVVYVVLLLLLLLLLLCCCCCCCCCCDDDDDDDDDDQQQQQQQQQQQQQQQQQQHQKKKKKKKKKKLIIIIIIILIAVVIVTVTAIVIVVIIQIVVHHHHHHHHHHFVMFVVMVFFLCCCCCCCLCFYYFYFYFFFGGGGGGGGGGPPPPPPPPPPLLILLLLLMLLLFLVLLILLRRRRRRRRRRFFFFFFFFFFLIILLLLLLLSRSSSSSSSSRKKRKKKKRRCCCCCCCCCTVVVVVVVVVVPPPSPEPPPPLLLLLLLLLLKKKRKKKKKKWLLWYWLWWW

----RR---KTTSVTSSSTAVLVLLLCLLLKTKKKKKKNRIIIIIIIIVTTSTRAAAASAIIIIIIIIIIAAAAAAAAAAEEEEAAEEEARRRRKKRKHKIFITIIIITI---L------VVVVVVVAVVWLWLWWWWLWEEEEEEQEEEPPPPPRPPPPEEEEDDEDEDRRRRRRRRRRLLLLLQLLLLAAASAAAAAAPPPPPPPPPPIIILIIIIIIGGGGVGGGGGLLLLAALVLAYYYYHHYHRRSTSTTTTTTTLVLLLLLLLLSAAASTAAAAVVVVVVVVVVQQQQQKQQQQDDDDDDDDEDTTTTTITTMSPPPPPPPPPPKKKKKKKKKKKGKKRKKKKKRRRREERERE------I---YVYYHHYHYHAAAATTAAATDDDDDDADDDTATTSSTTTSVVVVLLVLVLKKKKKKKKKK

TNNNCNCCNCCCCCCCCCCCVLLLLVLLLLSAVASTSTASAAAADAADVANDDDDDDEDDSTSSSSSSSSLLLLFLLFLLLLLLVLCVLLSQRSCSSCQSFFFFWFFFLFPPPPPPPPPPVIIIIVIIIINDNNNTNNNNPPPPPPPPPPIIIIIIVIIVVVVVVVVVVVVAAAVVVVVVEEEEEEEEEEDRKK-DD-KDHGRRRRRRRRIVVCLILLVLHHHHHHHHHHLLLLLLLLLLEEQEEEEEEESSSSASAASAAAAAAAAAAAFFFFFFFFFFGGGGGGGGGGK--KKKKR-KY--YYYFY-FLLLFLLLLLLYYYYYYYYYY

YYYYYYYYYYSAVAVVSVAVTTITIITIVIRRRRRRRRRRFMFMFFFFFFTSSSSSSSSSPPNPNNPNPDMLLLVLLLLLVSKSKTVKTT------A---------I---------Q---------F---------S---------A---------S---------E---------L---------D---------S---------I---------C---------E---------S---------K---------S---------P---------K---------G---------D---------V---TTTTTTTTTTYLLMLLLLMLSSSSSSSSSSKKRKRRKRKRIKIKIIIIKIYYYYYYYYYYRRGRGRRGRREEEE-EENEEQREREEQEQEAAAGAAAAAAMIVIVTMVMTPPAPAAPAPALLLFLILLLLTTSTSFTETFAAAAAAAAAAWWWWWWWWWWAAAA-AAAAALLMLMMLMLMVVVVVVVVVVEEEEEEEEEELMMMMIMMMINNNNNNNNNNAAASSAAAAAVVVVVVVVVVRERERRRRERASASAAAAAA-I-I------ASESEEAESEMLNLQMMQLMKKKKKKKKKKSRSRSSSSSSLLLLLLILLLLLLLLLLLLLIIIIIIVIIIFFVFIFFVFF

IFFMMMIFFMKKKKKKKKKK-T------D-YFFFFFFFYFGSSSSSGSSSGRGGGGGGGNIVILLLVIVLDNNEEEDNNERGRRRRRRNRHENNNNHRQNYHYYYYYYHYIVIVIVVVVVHHHHHHHEHHW--WWWW--WMAQMMLMMAMFIFTTTYFITVVVVVVVVVVSGSMLLSSSQ-------F---------A--EEEEEEEEEERKKRRRRKKRTSSAAATSSAYFFYYYYFFYQEEEEEEEEESSSAAAASSAYYFYYYYYYYGGLGGGGGGGHHNHYHHHHHLLLLLVLALVWYYFFFFYYFDEEEEESEEELLLLLLLLLLRRRKRKRRRKKRRRRKKRRKLL-LLLLLLLALLLLPALLL

MMVMVVVMVVLVVVVVVVVVYYYFYYYFYYLLLLLKLLLLGGGGGGEGGGLLLLLLLLLLKKNKNKKKNNEEGEGDDEGGVIVVVLIVVVSTRSRAASRREEEEEEEEEEHHHHHHHWHHAALVAAAVLL---------Q---------A---------VLLLLLLLLLLIIIIIVIIVVEPSEPPPEPPEEENEEEEEWAVVVVVVVVVAAAAAAGAAASSNENSSENNTSTTT-ATTTAAEAE-ATEETTTAT-TTTSIIVIV-VIVRNNNNN-NNNNVV-V---V--EHYHY--HYYVVVVV-VVVVTSTTT-TTTTMMIMM-MLIIEAAEA-AEAANNNTN-NTNNHHHHH-HHHHVVVVV-VVVVKKKKK-KKKKEEERE-EEEEHHFHF-FHFFVVVVV-VVVVTTVTV-VTVVGGGGG-NGGG

APPPPPPPPPAAAAAAAAAANNNNNNNNNNFFFFFFFFFFEDQEDEEEEQRLSCLLCCRNTMSMMSAMTSLFFFFFFFLYSASAASAAAS-L---------S---------A---------Y---------L---------N---------V---------P---------M--------KKKGKKGGKKDDDDDDDDDDDDDDDDEDDDVLVLLVLLVVDEDDENDDDDDTNTTNTTDNDEDEEDEEDDFNDNNSNNNDL---------NNNNNNNNNNEKKRKKRKKKDPDGGDGGDDRRRRRRRRRRTTTTTTTTTTLLLLLFLLLLQQQQQQQQQELIIIIIIIVIVIIVIIVVVIIQMQQMQQMMYYYYYYYYYH--------F---------P---------E---------T---------I-RKRNRRNRRREEEEEEEEQEDKLRKKKKKLDEKDDKEDDNSAAAAAAASALALLALLLLLVVVVVVVVVVAAAAAAAAAAKSKKSRKKKKIVVIVVVVIVEEEEEEEEEEYYYFYYFYYYVVVVVVVIVV

KRKKKKKKKETYQSTASSTTKKKKKKRKEKLILILIILLLEESEEEESEEDDDDHDDDHDVIVVTVVVVV----D---D-----S---S-----K---K-----S---D-----A---A-----E---A-----Q---P-----K---K-----G---G-AAAAAAAAAA---------T---------N---------L---------K---------QRQRHRQHRRRQEEQQEQERQFFFFFFFFFFFLLLLLLLLLPPPPPPPPPPQQQQQ-QQQQVIIVVVVLVVNNNNNNNNNNTTKVSTSTSTKKKKKKKKKKGGGGGGGGGGIVIVIIIIIIVVVVVVVVVVMLLLMLLMMMAGGGAGGGAARRRRRRRRRRGGTGGGGTGGIVIIIIIIIIEDEEEQEEEELLLLLLLLLLHQYRRQRRRRIIIIIIIIIIRSRRRSRRRRLLLLLLLLLLFFFFFFFFYFKRRRKRRRRKSSSSSSSSSSMMMMMMMLMMLRFLLLLMLLVIIIIIIIIVFLLLFLILFFVVVVIVVVIVNNNNNNNSNN

---I----I----G----G----S----G----N----N----H----H-QQHQQQQQQQFFFRFFFFRRLLLLLLLYLLGGGGGGGGGGYYYYYYYYYYPPPPPPPPPPLAVLALLLLLVVVIVIVMIIEEEEEEEEEEIIIIIIIIIV---------ITGTTTTTTTTVTVVVVIIVVGGGGGDGGGGFFFFFFFFFFQFMQQQQQQQNKKSKSNNSSTGGCKIAAGCTIILLLLLLLEEEEEEDDEEVVVIVIVVIIFFFFFFFFFFRKKKKKKKKRTATTTTTTTTPPPPPPPPPPDDDDDDDDDDCCCCCCCCCCAAAAAAAAAVRRRRRRRRRRNAALAANNAATVVTTTTKTTEEEDEEEEDDFFFFFFFFFFSGGGSGSSGGMMMMKMLLMMLIILILLLLLAPPAPSAAADHSNHHHHSHNDDDDDEDDDDEEEEEEEEEELLLLLLMMLLLLLNLNLLNN

AAAGAGGGAAVVVVIVVVVVHHHYHYYYHHEEEEEEEEEEDDDDDDDDDDHHHHHHHHHHRRRRRRRRRRLRL-L---LLRRR-R---RRPPP-P---PPLLL-L---LL-G--------VVV-V---VVGGG-G---GGAAA-A---AAVVV-V---VVEDD-E---DDGGG-A---GGNNS-N---SNAAAGAGGCAAKKKKKKKKKKLLLLLLLLIIKKKKKKKKKKEEEEEEEEEEAAAAAAAATTPPPPPPPPPPGGGGGGGGGGGGGGGGGGGGRRRRRRRRKKFFFFFFFFFFVIIMVMMLIIALLLLLLLLLGGGGGGGGGGNNNDNDDDNNRRRRRRRRERETEQEQQEEEYYYYYYHYFFKKKKKKKKKKNNNNNNNNND---K-KKK-----D-EDE-----Y-YYY-----D-DDD-----N-NSS--SSSSSSSSASPPPPPPPPPPFFFFVFFFFF--I-------

EEEEETEEEEKKKKKKKKKRTTTTTTTTTTNSNNNSNSNNEEEEEEEEEEDDDDDDDDDDTTTTTTTTTTTAASTAAASAAAAAAAAAAASASSSSSSSSGGGGGGGGGGNNNNNNNNNNDNNDDNDNDNFSSFFSSSFSIIIILIIIIIEEEE-EEEEEKAAA-AAAAAYFFY-FFFYFPPPP-PPPPPTDAT-STDTSTSSS-SASTSQHQQ-HQHQHFAAA-AAAAAEEEE-EEE-EQEQG-DQE-QAAACAASA-VEEEEEEEE-KAAAAAAAA-ALMMQLMMM-NEAEEEAEA-EHTTHHTTS-TTVTTTTTT-SYYYYYYYY-HTDSTTDSD-DFWFFFWFW-WRGRRRGRGRG

LLILLLLILLSSSSSSSSSSTTTTTTTTTTMLLMIVMMMMRKRRRRRRKRVVVVVVVIVVRRRRRRRQQQ-C---------G---------E---------S---------N--------IIIILIVIIIDDDDDDDDDDKEEKEEKKYKRTARTTRSKKAAAAAVAAAAGVVVVVVVVVDDDDDDNDDDFFFFFFFFFFVIIVIVVVVVEEEEEEEEEEETSEEEEEEEKRRKKKKKKKASSSSSSSSSASSSSSSSNSYYYYYYYYFYTVTTTTTTTTMMMMMMMMMMAAAAQQAAAALLLLLLLLLLQEEQEDQHQQPPPQPPPPPPIII-VVILLISSSSSLSSSSKKKKEKKKKKFFFFFFFFFFQAAQAAQHHQVVVVAVVIVVLLLLLLLLLLLMLVLLLLLLPPPPEEPPPPIIIIIIIILIFFFFFFFFFFFFFFFFFFFFAAAAAGSAAA

----P---------A---------G---------V---------I-----TTTTSTATTTRFFLFFRRILCTCCCCCCTCTSEADEMTSAIIIVVIIVIVSSSSSSSSSSLLLLLLMLLL--------A---------I---------F---------D---------A---------D---------P---------A---------V-FLFMFLFFLMVVVVVVVVVVVVVVVVVVVVNDDDDDNDDDEDNNPNNNDNLGAVAALLGVTQSSSQTSES---R-----KGGGGGGGGGGLLLLLMLILLLLLLLLLLLLPDPPPPPPPPCCCCCCICCCRDTSSTSSDSAAAAAAALAAAAAAALAAAANNNNNNNNNNAAAAAAAAAAYYYYYYYYYYDRRQRRDSRQTETTTTTTITHHHHHHHHH-DDDDDDDDD-A--V--EL-VRRRTRRRRRRQRKQEKQQKQDTTDTTDDTDGGGSGGGGGSLLLTLLLLLTKKKKKKKRKRYYYYYYYYYYYYYYVYYYYYGGGGGGGGGGVLIIVIVVVIV-----V---N-----N---G-----G---W-----W---M-----M---Q-----R---I-----T---AEATAAAPAA

-------I---------S---------D--VVVVCVVVVVVVVTVVVVVVRRRRRRRRRRR--K---K-KE--E---E-EK--S---Q-KP--T---P-PT--I---T-TR--R---K-RSSSSKSSSSS-G--------TSSSSSSSSSANSASAAASAQRRQRRRQRQQDDQEEEQDQHNNHNNSHNHGTTSSSSSTGTTTTSTTTTTGDGGGEEGGGTKKTKKKTKTPPPPPPPPPPAA-AATRASARR-RRRRRRSRR-RRRRRRRSSSSSSSSSSYWWWWWWWWWEEEEEEEEEEAPPPPPPPPERRRRRRRRRIVMMIIIIIMIPPKPPPPPPPWWWWWWWWWWAKRKKKKKKAGGGGGLGGGGVVVVVVLIVVASSASAAASALLLLLLLLLLQQSQKTTQPQIIIIIIIIIIGGGGGKKGGGVVVVVVVVVVYYYYYYYYYYLLVLHLLLLL

PPPPPPPPPPVIIILVVIILGGGGGGGGGGAAAEAAAATANNNTNTTNNNVVVVVVVVVVIINIDIINNDKKVRSRRSVSHHQKHKKHQQQQQQQQQQKQR-RRRRRKRRV-VIVIIVVVE-EEEEEEEED-DDDDDDDDR-KRCRKCKCS-SSTSSSSTD-DDDDDDDDV-VVVVVVVVG-GGGGGGGGRKKRKRRQKK------V---FFFFLFFLFLGGGGGGGGGGVVVVMALMVMLLLLLMLLLLLLILILLIIIAAAASAAAASAAAAAAAADAKKKDKKKKKKD---------A---------G---------G---------A---------S---------L---------M---------S---------YYYYYYYYYYQQQQQQQQQQ-------M--ATTTTTTTSTAASASAASSANNNNNNNNNNPPPPPPPPPPYYYYYYYYYYEKKNRNNRKRAMMFMFFMIMRRRRRRRRRREEEEEEEEEEFLLQLLLLLLIIIIVIIVIV

AVVVAVVAAVRRRRRRQRQQAAAAAATAAACCGGCCGCCGIIIIILIIYSDDDDDDDDDD---N---------M---------A---------K---------W---------I---------A---------S---------E------RRRRRRRRRRDNDDDGDDDDENDEEEEEEEA---------I---------D---------T---------S---------FFFFFFFFFFEEEEEEEEEESSSSSSSTSSKPPPPPPPPPAGAAAAAAAAKKKKKKKKKKLLLLLFMLLLRRRRRRRRKRLLILLLLLLSNGNNNGNNNNGGGGGGGGGG-ATAAAAAAAKKKKKRKKKKAAAAGAAAAAFFFFFFFFFFMMMMMMIMLISSLLSSLTTLSWWWWWWWWWVTVVVTVVVVQKRRKKRKKRDDDDDDDDDDSNKESNKSSKIIIIIIIVVILLMLLLLLLLGGGGGGGGGGYLIIYLLYYLLLLLLLLLLLLLLLLLLLLLWWWWWWWWWWYFWWYFWYYWSSSSSSSNSSGGCAGGAGGA

RRRRRRRRRRKKKKKKKKKKEEEEEEEEEELLLLLLLLLLAAPPAAAAAASGSSGGSGSSSTTTTTTTTTRKRRRKRKKRGGDDGGGGGGFFFFRFFFFYNNNNNNNNSNPPPPPPPPPPAASSDAAAADFFVVFFFFFFKEEEKEKEEKKTTTT-KTTTRRLRR-RRRRLLLLL-LLLLKHKKS-KHKKNNSNN-NNNNGGGGG-GGGGGDGGG-GDGGYYYYY-YYFYNNSSN-NNNNAAAAA-AATANNNNNNNNNNEEEDEEEEEERRRRRRRRRRNNNNNRNNNNPPPQPPPPPPRRRRRRRRRRVVVVTVVVVTSNNNNNSNNNQKHHQKQKKQTTTTTTTTQTAVVVAVAVVA

---------V---------I---------Y---------S---------D---------K---------V---------A---------TAAAAASAPASDDDDNDDDDD--N-----N---I-----I---N-----N---S-----T---L-----L-IINIIITINIKKKKKRKKKR-E--------SSSSSSSSNSDDDDDDDDDDDDDDDDDDDDVIGGGGGGGGWWRRRSRSRTNNNNNNNNNNVVIVVIVIVIRRRRRRRRRRHYYYYHYYYHVVVVVVVIVVAAAAAPAAAPVVVVVVVVVVNNANNNNNAAQQQQQQQQQQIIIVIIIIIVGGANGGGGQGAAAVATAAAANNSNNTQNSNKKKKKKKKKEGGGNGGGGHGRRKRRRRRRRILILLIIIIILLALLLALSLFFFFFYFYFYGGGSSYGYGYLLLLLLLLLLSSTSSGSSTGPPPPLPPPPPSASSSSSSSSGAGAAAAAAAEDDDDDDDDDKKKKKKKKKKLLLLLLLLLL--A-----A-QRRRRKRRRRFFFFFLFFSIDDDNDDDDEDVVIIIVIVIV

AAAAAAAAAATKRKTTRRNRVVVVVVVVVVLLILLLIIIIIIAIIMFIIFMFFFFFFFFFRKKKRRKKKKGGGGGGGGGGVPIVVVIIIIIVIVLIIIIIDDDDDDDGNDLVRVLARRRRVTTTVTGVTGGGGGGGGGGGPPPPPPPPPPLLLLLLLLLLVVVVLVVVVVNNNNNRNNNNGGAGGGAAAASSNSSSNNNNDDSDDDSSISWYWFWWWWWWEQEQEQEEEEIIIIIIIIII---------P---------Y---------D---------L---------Q---------V---------GYYHYYYFYYFAAAAAGAASAWYWYWWRWWWAAAAAAAAAADDDDDDDDDDFFFFYFFFFFQQQQQQQQQQGGGGGGGGGGLLLVLLLLLLSSAKNSAAAAQQQQQQQQTQHHHHHHPHHHCCECCCEEEE

FFFFFFFFFFGEGGGGGGGGDDADDDEADAEEEEEEEEEELLLLLLLLLLWWWWWWWWWWLVVIVIVVVVTILILIILLFMMMMMMMMMMVVVVVVVVVVFFLFLFFLLLIIIIIIIIIIIIIIIIIIIIGGRRKGRKKRVVVVVVVVAVVVVVVVVVVVTAAASTAASAHHHHHHHHHYGGGGGGGGGGIIIIIIVIIIGGGGGGGGGGIIILIIIVIINNNNSNNNNNSSASAANAAASSCSCSSCCS--N-D--NNNLLILILLIIIL----L----LMLMLLMLLLLLLLLLLLLLKKKKNKK-NKPPPPPPP-PPEEEGEEG-QLIILILII-LLIIVVFIV-VVGGGGGGGGGGYYYYFYYYFYSSSSSSSGSSRRRRRRRRRRVVTTTVMTTTWWWWWWWWWWTT---T----VV---V----HK---H----LL---L----GLNANAGNNN-LIIILIFIIRRRRRRRRRRLLLLLLLLLL------L---

EEEEEQEQQEQCCCCKCEEQRKKKKRKRKRLWLWLLWLLLEDDDEEDEEEDDDDDDDDDDRRRRRRRRRKVVVVVVVVVVMMMMMMMMMLSSSNSSSSSSDNNSNENEDDKKKKKKKQQKAAAAAAAAAAIVMVVIVIIVEDEDEEDEEEGAAAAAAAAAGGGGGGGGGGQQQQQQQQQEIIMIIILIIIVVVVVAVAAVTTTTTDTDTTSSFSFKSKKSVMMMMMLMMMQMQQQQQQQQGGGGSNGGGGGDDDDGDGGGCCCCCCCCCCLLLLLFLLLLLLLLFLLRLLEEEESEEEEEDHHHVDHDDDSNNNNNNNNS

VVVIVIIVIIRNNAKKAKAALLLLLLLLLLKAARRRRRRREEEEEEEEEEYYYYYYYYYYILLIILVIVVLVVLLVLLLLSGGCSSDSTCRYYKLYRYRRQQQRQQEQQRPPPPPPNPDPFFIFFFFFFYQNNEQNETEELLLLLLLVLLPPPPPPPPPPCCCCCCCCCCLLLLLLLLLLVLLVVVAVAVGGGGGGGGGGSSSSSSSSSSGGGGGGAGAGLIILLLLFLLAAAAAAAAAALLLLLLLLLLAAAAAAAAAMEEEEEEEEEELVVLLVLVLIGGGGGGGGGGNTNNNNNNNNLLLLLLLLVLRRRRRRRRRRGAAGGAGGGGYYYYYYYYYYYHTYYYWYYYQQQQQQQQQQDDDNDDDDDSRRKRRRRRKRFSSFFSINFFIIIIIIIIVIAAAHAAHAHHFFFFFFFFFF---G-----G

VVVVVVVVVVKKKFKKKAKEFFFFFTFFFFIVVIIASAIISASSSSYSSSLLLLLLLLLLVVVVVVVVVVDDGDGAGGDDFFFFFFFFFFLLLLLILLLLPPPPPQPPPPIIIIIVVIIVEEEQEETEEQPPPPPPPPPPDDDDDDDDDDVVVVVVIVVVSSTSTTTTSSLLMLFLLLLLRWHWWWWWWWKK-K-----KTTNTNNNNNTRATTTTTTTTLLFLLFFFLLEEEEEEEEEEFLFFLFFFFFTTTTTTTTTTIIMIIVVIIVYYYYFFFFYYQQQQPQNQQQTTTTTTTTTTAAGAAAAAAEVVVVVVVVVVPNHPPHHHPP

NNHNNQNNNNESEEEEEQEEAIIAAAAIAIVVVVVTVVSVEEEEE-EEEEDEDDD-DEDEEEKEE-EEEEDDDDD-DNDDRLLRLLLLLLEEEEEEEEEEIIIIIILIIYVIIVIIIIIIASSASSSSSSQQQQQEQQAQSSSSKSKSSSDDDDDDDDDDNIINNNNMHIGGCGGGGGGGEAEEEEDAEEDDDDDDDDDDREERRRREREKKKKKKKKKKVVVLVVVVVVIVVIIIVVIV--------R---------H---------A---------S---------Q-NSSNSSASSSTTTTTTSTITHHHHRHHHHH--------D-DEEDDDDESEQELQQQAEQLASRAAAAAARSSSSSSPSSSQSSQTSSSSSRRRKRRRRRRASSADADSASQQQQQQQQQQSASSTSSSSSSQESLSSQSETEEEEYEEYAFFFFFFFFFFQTQQQQQQQQKKKKKKKKKKHHHHHHHHHHQRQQQRQKRQ

YYYLYYYYYY-------N---------M---------M---------E---------I--VVVVVLVIVVKKKKKKKK-KQEAAAQAQAANNQQTSTNTTVIIIIVIIIITTTTTTTITTAGAAAAAGAAFFYYFFFFFFLVLVVVIVVVAAASTAAATA-YYYYYYYYY-GGGGGGGGG--II-------LNNSLNLSN--SSSSTSSSKKEDKKERKKMMQQMMQMMQA---------TTTTTTTTTTVVVVVVVVIVVVKKLLLILLGGAAGGAGGGRRQQQQQQQQTTTTTTTTTTHHHHHHHHHHFFLLLLLLLLLLLLLLLLLLLLLLLLLLLLFFFFFFFFFFAALLAAPAAPEEEEEEEQEEYYYYYYYFYYPPPPPPPPPPPPPPPPPTPPVVIVIVVVIVLLLLLLLLLLIIAAVVVLVVQQKKEQKQEEIIIIIIIIIIAAPPPAPAPPKKKKNKKKKKRRTHRRRRRRFLLQLALLLLVVIVVIIIIL

DDDDDDDDDDQQQEQQQQQESNNNNNNNNNVVVMIMMLMM----A---------V---------E---------T---------V---------L---------R-----SSNSESESSSSRRRRRRRRRAAAPAAAAAAGNNENTNNTEEEEEEEEEEEWWWWWWWWWWTTQQQQQTQEEEEKDEEEEEEEEETEDEEELLLLLLLLLLNDHQHQHNQQGGGAGGGGGAEEQQQQQQQQQQRQRERQEQGGDDDDDDDDGNKSNNNGNSRRRRRERRKRIIVFVFVIFFYYYYYYYYYY-------T--SESSSASSESTTTATTTTVHAAVAAAAAAAIIIFIVIIVFRRRRRRRRRRTSKNSNSGSNEEEEEEEEEQAAAAAAAAAATSSASASSSA---------D

MILLMLMMIMAAATATSSASGGAGGGGGGAEQERERQQEQCCCCCCCCCCFFFMFFFFFFHHHHHHNHHHKKKKKKKKKKVVVV-VVVVVRQQR-RRRQRLFFF-FFFFFPPPP-PPPPPDDDD-GNDDDAAAA-AAAAAEDDE-EEEDEVVVC-CLIVLNNNN-NQNRQLILL-LLLILGGGG-GGGGGGGGG-GGGGGEEEE-EEEEEEEEA-EEEEEFFFC-CCCFCAFAK-KKKFKEEEE-EEEEEEEEE-ELEELTTTT-TTTTTSSSK-KKKSKTTTT-TTTTTAAAA-AAAAAIIIL-LVIFVTLLL-LLLLL

PPPPPPPPPPPPPPPPPPPPVVVVVAVAVVMMLLMMLMMMDDDDEEDDEEIIIVIVIIIILILLLLLLLLVVVVIVVVIVVIVVVFVVVFFFLLFFLIFFKKKKKKKKKEVVVVLIVVLIVVIITTIVATRRKKKKEKKKVVIILLIILLKKKKQWKKQRTTVVKKVTKKLLFL-LLLLLIIVIVTLIVIQSSSSSSSSSSSMMCMMSCCPPPPPPPPPPTT--SA--SAAA--GA--GADD--EE--EEPP--PP--PPVV--AA--AASSDDSLNSSLAAASSAAASANNNTNDNNNDRRQRRRKRRRAEEEESEEESIVVVVVVVVVHHHHHHHHHHHHQHHHHHQHRRRRRRRRRRPPQHPPHHPPYYYYYEYYYYRRRKRHRRRHQQQQQQQEQDPPPPPPPPPPAAAAAAAAAATTTTTTTTTT

LMMLLMLMKLYYYYYYYYYYLLLLLLLLLLMMLMMMMMMLETTTTTTETTGGGGGGGGGGEETEEEYEEEVVVIVMVVVVSNPSASASSSDEEEEEEDDSTSATTASTATIIVIIIINIIFYYYYYYFYYDDDDDDKDDD--Y-------STSTTSTSSTEEEEEDEEEEVVIVVIVVIIYYYYYYYYYYSTSTTSTSSTNGDDDDDDDDRRRRRRRRRRDDSDDDDDDDLLLLLLLLLLQGEGGEGQEGAATAATAATACFYFYFFCYYVVIVVVVIVKVVVVAIAVVVASSSSSSSSSSSSSSSDTQSKMKMMKMKKMEEQQEEEEEEVVVVVV-VVVVIVVVVVVVIHHHKHHHHHHVIVIIVIVVVPPPPPPPPPPVVVVVVVVIVGGGGKGGGGGKRLRRLRKLHSPLPPAPSSPLLLLLMLLLL

LLLLLLLLLIILLLLLLLLLCSCCCSSSSCASSSSSSSKSDDDDDDDDDDIFIIIIFIFLQPNQNPPPPNKKKKKKKKKQGGGGGGGGGCPAPPPPPPPEVVVVVVLVVITTTHTTTTTTDEDDDEEEEELVLVVNVNVVDDDDDDDDDESSSSSSSSSSFFFFFYFFFFQQQQQQQQQQIVIIIVVVAVGGGLGGGGGGTLLLLLLLLLEEEEEKEEEERRRRRGRGRR-C---NCCCIGGGGGGGGGGS-TSS----SSSASSSSSSSTTTTTTTTTTDDDDDADDDDIVIIIIIIIIDDGDDDDDDDEEEEEDEEEEIIIIFIIIIVRRRRRKRKRRLLLFLLLLLLFFFFFFFFFFNNNKNNNNNNKKKKKEKKKKVGAAAGGGGAKSKKKSSSSKAAAAAAAAAAWWWWWWWWWW

RRQRQQQRQQKKQKQQQQHQLLVLVVAVVMSSNSNNNSNNIIVIIIIIIIHYYYYVYYYYLLLLLLLLLLQQPQPPPEPKAAAAAAAAAALAAAAAAAAAPPGSGSGSGGKKKKKKKRKKHHHHHHNHHHHHHHHHHHHHSSISIIISIILLVLIIIIIITNVALVLVLLRRRRKQRRRRDDDDDDDDDDLLLLLLLLLIFFFFFFFFFFNNNNNNNNRNEYYYYRYYYYDDDDDDDDDDVIQLQQQQQQRRRRRRQRKTLIIIIIIIIIFFFFFFFFFFGGGGGGGGGG---E---------F---------K---------A---------R------LLCLCCCWCCGGGGGGGGGGVVIVIIIIII--------K---------R---------L---------D-QGRRNRRRRRGGGGGGGGGGLLMLFLFLFFMLMMLMMMMMWWWWWWWWWWDDEDEEEEEEPAPPPPPPPPLLLLILLLLLQQHQQQQQQERRKRKRKRKK

LLLLLLLNLLIAVVVVIVVITTIIIISLITSSAAAASAAAAQQDQQQQQQLLLLLLLLLLDDDDDDDDDDTTSSSSTSSTIFIIIIIIIIKKKKRTKKKKVVVVVVVVVVLLVLVLLLVLDDDDDDDDDDKKAAAAKAAAILLLLLLLLLQQQQQQQQQEGGGGGGGGGGRRKKKKRKKKEEEEEEAEEEIIIVIVVVIVGGGGGGGGGGLLWLWLLFWLYYYYHYYYYYMLMLLLMLLLKKRRRRKRRRPPPPPPPPPPKKRKKKRKKKVLKNKNIKKKYYLYLYYYFEFP----P-----IFVF-FFFTTTTTTTTTNWW----W--WMMLLLLMLLMYYFFFFYFFQLLLLLILLLLAAAAAASAAARRPPPPRPPRAGAAVAAAGKKKKKRKKKKE-AQAAA-AAQAEVDVDAAVSGAAAAAGAAA

TTTTTTTTTTKAKRKKKKKKEEEEEEMEEERRRRRRRRRRIIITVEIIIVNNNNNNNNNNFFFFFVFFFFSSSSASSSSSLLLLVLLFLIILIILIIIILSTTSTSQTSTAAAAAAAAAAGGGGGGGGGGLMMLLLMTLLEEEEEEEEEEVVVIVILVIFVVKVVVVVVVQQQQAQQQQQAAAASAAAAAGGGGGGGGGGGEGGEGNGGEQHNQHQQQQHSASESSSSSSIIVIIIIIVVEEEEEEEEEEMAAMAMMAMAATTGKAAAAKGGGGGGGGGGQQQQQQQQQQGAAGEGGAGKPPPPPPPPPPVVVVVV-VVVEEEGEGEEGENDDNDNNDNDLLLMLLLLMLILIIFIIIILYYYYYYYYYFIIILIIVIIVMMMMMMMVTMFYYFYFFFFYIVIIVIVIIVIIVIIIIII-

GGGGDGGNGGEERKSEEREETTKKKKKKKKHHDDDDDDDDLLLTNTTLTTNNDNNNNDNNEEEEEEEEEETTTTLNRTNTCCCCCCCSCCGGGGGGGGGGVVVVVVVVLVRRRSSSARSRSNNNTTTNTNEEEDEEEEEE--K----K--IITVVVVVVITTTTRVTTTTKKRAKNNKKKRRRNNKNRNREEEEEEEEEESASSSTSSSSKKKKKKKKKKNNNNNNNNNNLLLFFFFLFLYHHHFHHHHHPPPPPPPPPPTTVTTTTVTTFFFFFFLFFFGGGKRKKGKKVWVVVVVVVVIIIIIIIIIIQQQQQQQQQQIVVVLLVVVVNNSNSSSSNNRRKRRRRKKRRRRRRRKRRRAAAAAAAANAIIVIIIIVIIAAAAAAAAYAFFLFYYFLFFCCCCICCCNC

AAAAAAAAAAVVPPPVVVWWSSSGSSSSSSPPPPPPPPPPCCSSSSSSCCRKKKKMQ-KKRRRRRRRRRRAAAAAAQQAASSAAAASSSSWFWWWWWWWWHHHHSYHH-HLLLLLLLL-LIIAVVAII-ILLLLLLLI-LLLLLLLLL-LT-SSNSTS--GGGYHGGGGGGGGGGGGGGGLLILIILLLLWWYWWYWWWWIVIMMIIIIIHLHHHHHLYHEKEEEEEEEERRRQRRRRRREEDEEDEEEEEEEEEEEEEEEEEEEEEEEEPPPPSPPPPPVFFFFYFFFFVVVVGVV-VVTTTTATT-TT-VIIVII---GGGGGGG-GGGGGGGGG-GGVVVVVVVVVVIVIIIIIIILSGTSSSSSGGDESDDDDDEETMMMMMMMTMLLLFFLLLLLRR----RRRRGG----GGGG

FFFFFFFFFFLLLHHFFFHHHHRNHHHHNHWWWWWWWWWWKKKQQKKKQQPPPPPPPPPPYYYYYYYYYYFFFFFFFFFFLILLLLLLLLEEEDDAAADDQQQQQTTQQQHHHEEEEEKEKKKKKVVVKKASAAAAAAAALLLIILLLILYYYHHYYYHYLLLLLLLLLLYAYYYYFYYYIIVVVVVVVVVVVIVAVVIVLLLLLLLLLLSSSSSSSSSSKKKKKKKKKKAAAAAAAAAAVVVIIVVVIVHHHYYY-YYYIIIIVL-IIVDDDDDE-DDDRRRNNN-NENVVVVVV-VVVNNNNNNNNNNPPQPPPPPPP

SSSSSSSSSSSHIHSAQQKAEEEEEEEE-EKKKKKKKKKKSAASASAASSLLLLLLLLLLYYYYYHHHYYLLLLLLLLLLGGGGGEGGEEAAAAAATTAAETEEEEEEEEQQQQQQQQQQEQEEEEKKEELLLLLLLLLLIMMIIVIIIVTNTTTTTTTTNNNNNNQNNNSGGGSSGGSCLLLLLLLLLLGGGGGGGGNGLLLLMLLLLLQRKQQQEDQQRRRRRRRCRRNNNNDNNNNNYYYYYYYYYYMLLLLLLLLMNNNNNNYTNNVVVVVEIIVEPPPKPPPPPPTTTSTTTTTTVVVVVVVTIIYYYYYYFFYYVVVVVVVVVVN-NNNNNNNNRRRRRERREESTTTSSTTSSQWWWSKRRQQGGGGIGGGGGNNNNNNNNNNTTTTTTTTATYYYYYYYYYYCCCCCCCACF

AAAAAAAAAANGGNNNNNGNQQQQQQMQQQAAAAAVVAAVEQQEEEEEQETPPTTTTTPTDDDDDDDDDDYYYYYFTYYFKKKKKKKKKKEEEEEEEEEEKKGKEKKEGTRQKREQQQRQCCFCVVVVFVSAASAAAAAADDDDDDDDDDTTTTRTTTTTTTTTTSTTTTDEDDDDDDDDIILIIIIILIVVVVTVLIVVAAALAAAAAARRRRRRRRRRAAAAAAAAAAKKTKKKKKTKDEEDEDEEEEKKRKEKKERKGGGGGGAGGGLLLLIMMILMEEEEEEDEEAVVVIVVVVVVEEEEEEEESEPPPPPSDPPPEEEREEEEEEHHRHHHHQQHAAAAAAAAAAWWWWWWWWWWVVLVVVAVIVAKEKEDEEKEKQAKKKKKQKAAASPPPPAPEEEPEEEEEEEEEEEEEEEEPPPPPPPPPP

AAAAASYAAAPPPPPPPPPPVASAVSVVASSSSSSSSSSSKKKKKKKKKKEREEEREEERYYYYYYYYYYILLIIIIIILIVIIIVIIIVLLLLLLLILLYHHHYSHHHHFNHFFHLLFHKKKKKKKKKKFFFFFFFFFF-----Q---Q-----S---S-----K---K-----K---KKKKKKKKKKKQPPPQPQQPPRRRSRRRRSRIVVVIVVVVTEDEDEDEEHDIIIIIVIIIITSCATWTTSCIIIVIIIIIIKKKKKKKRRKVVVLVTVVVTNNNENNNNENFFFFAFFFFFPPPPPPPPPPGGGGGSGGGGQQQRQQTQLQEEEEEEEEEEIIIIIIIIIIEEEEEEEEEETSTTTLTTTLCCCCCCCCFCKIKQRKKKEEFMFYFFFFFFMSSSMSMMSSLLLLLLLLLLGGGG-GAGGGRRRA-RRRARNNNN-NSNNNYYYF-QYYFY

CCCCCSSCCCTKKKRKKT-KQSQCQQQQQCYSSCSSSTTTCCCCCCCCCCVVVVVVVVFVTASSNSSTSSRRRRRRRRRRDDDDDDDDDDDKKKKKKKKKIIIIIIITIIHHHHHHHHHHKKKKKKTKKKEEEKEEQEAKMVVMVVVMMMAASTSAAASTVVIVVVIVIVAAAAAAAAAALLLILLFLLLDDDDDDDDDDDDDDDDDDDDQQQQQQQQQQQQQQQQQQQQDDDDDSTDDDFFFFFFFFFF-------L---------M---------K---------G---------F--FAAFPAAFAFYYYYYYYYYYGGGGGGGGGGQRQQRQQQQQNGGNGGGNGNLLLLLLLLLLYYYYYYYYYFILIILIIIIIPPPPPPPPSPPPPPPPPPPPLLLLLVVLLL------A---------S---------S---------E---------M---------Q---------F---------E---------V---------R---------D---------D---------N---------L---------V---------R---------T---------L---------Y---------T---------N---------L---------R---------V---------T---------P---------E---

IILVLIIIILDDDDDDDDDDFFFFYFLFFFFYYYYYYYYYKLLLLLLQLLAAAAAAAAAALLLLLLLLLLYYYYYYYYYYFFFFFFFFFFKKKKKKKKKKFFFYFFLFFFMMILLMMMLITTTTTTTTTTEEMQQEEEMMPPLLLLMPLIYYHHHYYYHHVVVTVTVVIVKKSSSVKKSSSSSSSSSSSPYYMMMYYYMHCCCCCCCCCCRRQQQRRRQQTSMMMLTSMLNNNNNNNNNNMLLLLLLLLLNNATRNNNAAAAAAAAAAAAGGGGGGGGGGTSVVVTTSIVPPPPPPPPPPALLLLLLLLLVTVVVVVTVVSASSSSSSSSEEEEEEEEEENDEDDDDDEQEEEEEEEEEE

DDDDDDDDDDPPPPPPPSPPKKNKKKKKEEVIIFIIIIIIAAASAASAAASSSSSSSSSSHHHSHNNHNNLLLLVLLLVLCCCCCCCCCCDHDHHFFHFFKKKVKKKKVVGGGGGGGGEEMFLLLYHLYYFFFFFFFFFFEEEEEEEEERKKKQKQQQQQRRRHRFHRFFVLLILLLLLLIVIVVVVVVVTAAAASAASSPPPPPPPPPPSSSSSSNSSSQQHQQQQQQQDDDGDDDDNNRRRRRRRKRRLVLILQLILLAVAVAVVVVVLLLLLLRLLLYYYYYYYYYYEDEDEDDDEDNNNNNNNNDSRRRRRRRRRRVFVVVVVVVVDDDDDDDDDDSSSSSSSSSSYYYYYYYYYY

EDDDEDEDEEPLIIPPPPPPLLKLLILLLLAFFFAWAWAAMFFFLLVLLLQTQRQQQKQQAQAAAAAAAADEDDSDKDDDTTAATTTTTTRRRRRRRRRRTTTTTTTETTFFFFFFFFFFGSSSSSKLKSSNTTTTTLTTLLLLLLLLLLYYYYFYYYYYKKKKKKKKKKNNNDNNNNNNRRRRDRRRRREEEEEEEEEEKGKKKKRKQKTTTTTTTTTTIIIIIIIIIITYHHHHMHMYILLLLLLLLIPPPPPPPPPPLVVVVVVVALAAAAAAAAAATTTTTTTTTTEEEEEEEEEETTTTTTSTTTVVVVVVVVVVHHNHHHHHHHKKKK-K-K-KEEEE-E-E-EHHHH-H-H-HRIII-R-R-RVVVV-V-I-VEREE-D-D-EFFFF-F-F-FRRRR-R-R-RLTTT-T-T-MHHHH-H-H-H

LLLLLLLLLLFFFFVFFFFFDEEEEEEKKEIVVIVIIIIVTTTTSTTIIT-------S--FVVFVIIFFVSTSSRSRSSTRRRRRRRRRRI-II-TVLL-D-DD-DDDD-E-EE-EEEE-N-NN-NNGG-V-VV-AACI-E-EE-KEEE-R-LR-RRRR-R-QR-QQRR-K-KK-KKKK-K-KK-KKTT-E-EE-EEEE-I-VI-VIII-P-PP-PPPP-L-LL-LLLL-A-AA-AAAA-E-EE-EEEE-T-FT-FFFF-G-GG-GDGG-V-VV-VVVV-K-KK-KKKK-H-IH-HSHH-F-FF-FFFF-G-EG-EEEE-E-EE-EEEE-A-SA-AAAA-T-LT-LLLL-D-EE-KEEE-K-KK-NKKK-