Datasets:

huy-nh-2000

/

instructUIE

like 0

[]

{ "id": "0", "sentence": "IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase .", "label": " ( protein: 5-lipoxygenase, None) , ( protein: NF-kappa B, None) , ( DNA: IL-2 gene, None) , ( protein: CD28, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: 5-lipoxygenase, None) , ( protein: NF-kappa B, None) , ( DNA: IL-2 gene, None) , ( protein: CD28, None) " }

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{ "id": "1", "sentence": "Activation of the CD28 surface receptor provides a major costimulatory signal for T cell activation resulting in enhanced production of interleukin-2 ( IL-2 ) and cell proliferation .", "label": " ( protein: CD28, None) , ( protein: CD28 surface receptor, None) , ( protein: IL-2, None) , ( protein: interleukin-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD28, None) , ( protein: CD28 surface receptor, None) , ( protein: IL-2, None) , ( protein: interleukin-2, None) " }

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{ "id": "2", "sentence": "In primary T lymphocytes we show that CD28 ligation leads to the rapid intracellular formation of reactive oxygen intermediates ( ROIs ) which are required for CD28 -mediated activation of the NF-kappa B / CD28 -responsive complex and IL-2 expression .", "label": " ( protein: CD28, None) , ( protein: CD28, None) , ( protein: CD28, None) , ( cell type: primary T lymphocytes, None) , ( protein: NF-kappa B, None) , ( protein: CD28 -responsive complex, None) , ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD28, None) , ( protein: CD28, None) , ( protein: CD28, None) , ( cell type: primary T lymphocytes, None) , ( protein: NF-kappa B, None) , ( protein: CD28 -responsive complex, None) , ( protein: IL-2, None) " }

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{ "id": "3", "sentence": "Delineation of the CD28 signaling cascade was found to involve protein tyrosine kinase activity , followed by the activation of phospholipase A2 and 5-lipoxygenase .", "label": " ( protein: 5-lipoxygenase, None) , ( protein: phospholipase A2, None) , ( protein: CD28, None) , ( protein: protein tyrosine kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: 5-lipoxygenase, None) , ( protein: phospholipase A2, None) , ( protein: CD28, None) , ( protein: protein tyrosine kinase, None) " }

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{ "id": "4", "sentence": "Our data suggest that lipoxygenase metabolites activate ROI formation which then induce IL-2 expression via NF-kappa B activation .", "label": " ( protein: IL-2, None) , ( protein: NF-kappa B, None) , ( protein: lipoxygenase, None) , ( protein: lipoxygenase metabolites, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2, None) , ( protein: NF-kappa B, None) , ( protein: lipoxygenase, None) , ( protein: lipoxygenase metabolites, None) " }

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{ "id": "5", "sentence": "These findings should be useful for therapeutic strategies and the development of immunosuppressants targeting the CD28 costimulatory pathway .", "label": " ( protein: CD28, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD28, None) " }

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{ "id": "6", "sentence": "The peri-kappa B site mediates human immunodeficiency virus type 2 enhancer activation in monocytes but not in T cells .", "label": " ( DNA: peri-kappa B site, None) , ( cell type: monocytes, None) , ( cell type: T cells, None) , ( DNA: human immunodeficiency virus type 2 enhancer, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: peri-kappa B site, None) , ( cell type: monocytes, None) , ( cell type: T cells, None) , ( DNA: human immunodeficiency virus type 2 enhancer, None) " }

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{ "id": "7", "sentence": "Human immunodeficiency virus type 2 ( HIV-2 ), like HIV-1 , causes AIDS and is associated with AIDS cases primarily in West Africa.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "8", "sentence": "HIV-1 and HIV-2 display significant differences in nucleic acid sequence and in the natural history of clinical disease.", "label": " ( DNA: nucleic acid sequence, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: nucleic acid sequence, None) " }

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{ "id": "9", "sentence": "Consistent with these differences, we have previously demonstrated that the enhancer/promoter region of HIV-2 functions quite differently from that of HIV-1 .", "label": " ( DNA: enhancer/promoter region, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: enhancer/promoter region, None) " }

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{ "id": "10", "sentence": "Whereas activation of the HIV-1 enhancer following T-cell stimulation is mediated largely through binding of the transcription factor NF-kappa B to two adjacent kappa B sites in the HIV-1 long terminal repeat , activation of the HIV-2 enhancer in monocytes and T cells is dependent on four cis-acting elements : a single kappa B site , two purine-rich binding sites , PuB1 and PuB2 , and a pets site .", "label": " ( DNA: pets site, None) , ( cell type: monocytes, None) , ( DNA: PuB1, None) , ( DNA: HIV-1 enhancer, None) , ( DNA: kappa B sites, None) , ( cell type: T cells, None) , ( protein: transcription factor, None) , ( DNA: purine-rich binding sites, None) , ( protein: NF-kappa B, None) , ( DNA: cis-acting elements, None) , ( DNA: HIV-2 enhancer, None) , ( DNA: kappa B site, None) , ( DNA: HIV-1 long terminal repeat, None) , ( DNA: PuB2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: pets site, None) , ( cell type: monocytes, None) , ( DNA: PuB1, None) , ( DNA: HIV-1 enhancer, None) , ( DNA: kappa B sites, None) , ( cell type: T cells, None) , ( protein: transcription factor, None) , ( DNA: purine-rich binding sites, None) , ( protein: NF-kappa B, None) , ( DNA: cis-acting elements, None) , ( DNA: HIV-2 enhancer, None) , ( DNA: kappa B site, None) , ( DNA: HIV-1 long terminal repeat, None) , ( DNA: PuB2, None) " }

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{ "id": "11", "sentence": "We have now identified a novel cis-acting element within the HIV-2 enhancer , immediately upstream of the kappa B site , designated peri-kappa B .", "label": " ( DNA: kappa B site, None) , ( DNA: cis-acting element, None) , ( DNA: peri-kappa B, None) , ( DNA: HIV-2 enhancer, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: kappa B site, None) , ( DNA: cis-acting element, None) , ( DNA: peri-kappa B, None) , ( DNA: HIV-2 enhancer, None) " }

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{ "id": "12", "sentence": "This site is conserved among isolates of HIV-2 and the closely related simian immunodeficiency virus , and transfection assays show this site to mediate HIV-2 enhancer activation following stimulation of monocytic but not T-cell lines .", "label": " ( DNA: HIV-2 enhancer, None) , ( cell line: T-cell lines, None) , ( cell line: monocytic, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: HIV-2 enhancer, None) , ( cell line: T-cell lines, None) , ( cell line: monocytic, None) " }

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{ "id": "13", "sentence": "This is the first description of an HIV-2 enhancer element which displays such monocyte specificity, and no comparable enhancer element has been clearly defined for HIV-1 .", "label": " ( DNA: enhancer element, None) , ( DNA: HIV-2 enhancer element, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: enhancer element, None) , ( DNA: HIV-2 enhancer element, None) " }

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{ "id": "14", "sentence": "While a nuclear factor (s) from both peripheral blood monocytes and T cells binds the peri-kappa B site , electrophoretic mobility shift assays suggest that either a different protein binds to this site in monocytes versus T cells or that the protein recognizing this enhancer element undergoes differential modification in monocytes and T cells , thus supporting the transfection data.", "label": " ( cell type: T cells, None) , ( cell type: monocytes, None) , ( cell type: T cells, None) , ( DNA: enhancer element, None) , ( cell type: monocytes, None) , ( protein: nuclear factor, None) , ( cell type: peripheral blood monocytes, None) , ( cell type: monocytes, None) , ( cell type: T cells, None) , ( DNA: peri-kappa B site, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( cell type: monocytes, None) , ( cell type: T cells, None) , ( DNA: enhancer element, None) , ( cell type: monocytes, None) , ( protein: nuclear factor, None) , ( cell type: peripheral blood monocytes, None) , ( cell type: monocytes, None) , ( cell type: T cells, None) , ( DNA: peri-kappa B site, None) " }

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{ "id": "15", "sentence": "Further, while specific constitutive binding to the peri-kappa B site is seen in monocytes , stimulation with phorbol esters induces additional, specific binding.", "label": " ( DNA: peri-kappa B site, None) , ( cell type: monocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: peri-kappa B site, None) , ( cell type: monocytes, None) " }

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{ "id": "16", "sentence": "Understanding the monocyte-specific function of the peri-kappa B factor may ultimately provide insight into the different role monocytes and T cells play in HIV pathogenesis .", "label": " ( protein: peri-kappa B factor, None) , ( cell type: monocytes, None) , ( cell type: T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: peri-kappa B factor, None) , ( cell type: monocytes, None) , ( cell type: T cells, None) " }

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{ "id": "17", "sentence": "E1A gene expression induces susceptibility to killing by NK cells following immortalization but not adenovirus infection of human cells .", "label": " ( DNA: E1A gene, None) , ( cell type: human cells, None) , ( cell type: NK cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: E1A gene, None) , ( cell type: human cells, None) , ( cell type: NK cells, None) " }

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{ "id": "18", "sentence": "Adenovirus (Ad) infection and E1A transfection were used to model changes in susceptibility to NK cell killing caused by transient vs stable E1A expression in human cells .", "label": " ( protein: E1A, None) , ( cell type: human cells, None) , ( protein: E1A, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: E1A, None) , ( cell type: human cells, None) , ( protein: E1A, None) " }

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{ "id": "19", "sentence": "Only stably transfected target cells exhibited cytolytic susceptibility, despite expression of equivalent levels of E1A proteins in Ad-infected targets .", "label": " ( protein: E1A proteins, None) , ( cell line: Ad-infected targets, None) , ( cell line: transfected target cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: E1A proteins, None) , ( cell line: Ad-infected targets, None) , ( cell line: transfected target cells, None) " }

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{ "id": "20", "sentence": "The inability of E1A gene products to induce cytolytic susceptibility during infection was not explained by an inhibitory effect of viral infection on otherwise susceptible target cells or by viral gene effects on class I MHC antigen expression on target cells .", "label": " ( cell type: target cells, None) , ( cell type: target cells, None) , ( DNA: viral gene, None) , ( DNA: E1A gene, None) , ( protein: class I MHC antigen, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: target cells, None) , ( cell type: target cells, None) , ( DNA: viral gene, None) , ( DNA: E1A gene, None) , ( protein: class I MHC antigen, None) " }

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{ "id": "21", "sentence": "This differential effect of E1A expression on the cytolytic phenotypes of infected and stably transfected human cells suggests that human NK cells provide an effective immunologic barrier against the in vivo survival and neoplastic progression of E1A-immortalized cells that may emerge from the reservoir of persistently infected cells in the human host .", "label": " ( cell type: human NK cells, None) , ( cell line: E1A-immortalized cells, None) , ( cell type: human cells, None) , ( protein: E1A, None) , ( cell type: NK cells, None) , ( cell type: persistently infected cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: human NK cells, None) , ( cell line: E1A-immortalized cells, None) , ( cell type: human cells, None) , ( protein: E1A, None) , ( cell type: NK cells, None) , ( cell type: persistently infected cells, None) " }

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{ "id": "22", "sentence": "Distinct signaling properties identify functionally different CD4 epitopes .", "label": " ( protein: CD4 epitopes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD4 epitopes, None) " }

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{ "id": "23", "sentence": "The CD4 coreceptor interacts with non-polymorphic regions of major histocompatibility complex class II molecules on antigen-presenting cells and contributes to T cell activation .", "label": " ( protein: CD4 coreceptor, None) , ( protein: non-polymorphic regions, None) , ( cell type: antigen-presenting cells, None) , ( protein: major histocompatibility complex class II molecules, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD4 coreceptor, None) , ( protein: non-polymorphic regions, None) , ( cell type: antigen-presenting cells, None) , ( protein: major histocompatibility complex class II molecules, None) " }

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{ "id": "24", "sentence": "We have investigated the effect of CD4 triggering on T cell activating signals in a lymphoma model using monoclonal antibodies ( mAb ) which recognize different CD4 epitopes .", "label": " ( protein: CD4, None) , ( protein: monoclonal antibodies, None) , ( protein: mAb, None) , ( protein: CD4 epitopes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD4, None) , ( protein: monoclonal antibodies, None) , ( protein: mAb, None) , ( protein: CD4 epitopes, None) " }

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{ "id": "25", "sentence": "We demonstrate that CD4 triggering delivers signals capable of activating the NF-AT transcription factor which is required for interleukin-2 gene expression .", "label": " ( protein: interleukin-2, None) , ( protein: NF-AT transcription factor, None) , ( protein: CD4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: interleukin-2, None) , ( protein: NF-AT transcription factor, None) , ( protein: CD4, None) " }

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{ "id": "26", "sentence": "Whereas different anti-CD4 mAb or HIV-1 gp120 could all trigger activation of the protein tyrosine kinases p56lck and p59fyn and phosphorylation of the Shc adaptor protein , which mediates signals to Ras , they differed significantly in their ability to activate NF-AT .", "label": " ( protein: Ras, None) , ( protein: anti-CD4 mAb, None) , ( protein: NF-AT, None) , ( protein: HIV-1 gp120, None) , ( protein: Shc adaptor protein, None) , ( protein: protein tyrosine kinases, None) , ( protein: p59fyn, None) , ( protein: p56lck, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Ras, None) , ( protein: anti-CD4 mAb, None) , ( protein: NF-AT, None) , ( protein: HIV-1 gp120, None) , ( protein: Shc adaptor protein, None) , ( protein: protein tyrosine kinases, None) , ( protein: p59fyn, None) , ( protein: p56lck, None) " }

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{ "id": "27", "sentence": "Lack of full activation of NF-AT could be correlated to a dramatically reduced capacity to induce calcium flux and could be complemented with a calcium ionophore .", "label": " ( protein: NF-AT, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-AT, None) " }

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{ "id": "28", "sentence": "The results identify functionally distinct epitopes on the CD4 coreceptor involved in activation of the Ras /protein kinase C and calcium pathways .", "label": " ( protein: CD4 coreceptor, None) , ( protein: /protein kinase C, None) , ( protein: Ras, None) , ( protein: epitopes, None) , ( protein: Ras /protein kinase C, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD4 coreceptor, None) , ( protein: /protein kinase C, None) , ( protein: Ras, None) , ( protein: epitopes, None) , ( protein: Ras /protein kinase C, None) " }

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{ "id": "29", "sentence": "Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen receptor .", "label": " ( protein: estrogen receptor, None) , ( protein: GATA-1, None) , ( protein: erythroid transcription factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: estrogen receptor, None) , ( protein: GATA-1, None) , ( protein: erythroid transcription factor, None) " }

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{ "id": "30", "sentence": "High-dose estrogen administration induces anemia in mammals .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "31", "sentence": "In chickens, estrogens stimulate outgrowth of bone marrow-derived erythroid progenitor cells and delay their maturation .", "label": " ( cell type: bone marrow-derived erythroid progenitor cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: bone marrow-derived erythroid progenitor cells, None) " }

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{ "id": "32", "sentence": "This delay is associated with down-regulation of many erythroid cell-specific genes , including alpha- and beta- globin , band 3 , band 4.1 , and the erythroid cell-specific histone H5 .", "label": " ( DNA: band 4.1, None) , ( DNA: band 3, None) , ( protein: H5, None) , ( DNA: erythroid cell-specific genes, None) , ( protein: erythroid cell-specific histone, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: band 4.1, None) , ( DNA: band 3, None) , ( protein: H5, None) , ( DNA: erythroid cell-specific genes, None) , ( protein: erythroid cell-specific histone, None) " }

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{ "id": "33", "sentence": "We show here that estrogens also reduce the number of erythroid progenitor cells in primary human bone marrow cultures .", "label": " ( cell line: primary human bone marrow cultures, None) , ( cell type: erythroid progenitor cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: primary human bone marrow cultures, None) , ( cell type: erythroid progenitor cells, None) " }

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{ "id": "34", "sentence": "To address potential mechanisms by which estrogens suppress erythropoiesis , we have examined their effects on GATA-1 , an erythroid transcription factor that participates in the regulation of the majority of erythroid cell-specific genes and is necessary for full maturation of erythrocytes .", "label": " ( cell type: erythrocytes, None) , ( protein: erythroid transcription factor, None) , ( protein: GATA-1, None) , ( DNA: erythroid cell-specific genes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: erythrocytes, None) , ( protein: erythroid transcription factor, None) , ( protein: GATA-1, None) , ( DNA: erythroid cell-specific genes, None) " }

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{ "id": "35", "sentence": "We demonstrate that the transcriptional activity of GATA-1 is strongly repressed by the estrogen receptor ( ER ) in a ligand-dependent manner and that this repression is reversible in the presence of 4-hydroxytamoxifen .", "label": " ( protein: ER, None) , ( protein: estrogen receptor, None) , ( protein: GATA-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ER, None) , ( protein: estrogen receptor, None) , ( protein: GATA-1, None) " }

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{ "id": "36", "sentence": "ER -mediated repression of GATA-1 activity occurs on an artificial promoter containing a single GATA-binding site , as well as in the context of an intact promoter which is normally regulated by GATA-1 .", "label": " ( DNA: artificial promoter, None) , ( protein: GATA-1, None) , ( DNA: intact promoter, None) , ( DNA: GATA-binding site, None) , ( protein: ER, None) , ( protein: GATA-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: artificial promoter, None) , ( protein: GATA-1, None) , ( DNA: intact promoter, None) , ( DNA: GATA-binding site, None) , ( protein: ER, None) , ( protein: GATA-1, None) " }

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{ "id": "37", "sentence": "GATA-1 and ER bind to each other in vitro in the absence of DNA.", "label": " ( protein: ER, None) , ( protein: GATA-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ER, None) , ( protein: GATA-1, None) " }

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{ "id": "38", "sentence": "In coimmunoprecipitation experiments using transfected COS cells , GATA-1 and ER associate in a ligand-dependent manner .", "label": " ( protein: GATA-1, None) , ( cell line: COS cells, None) , ( protein: ER, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GATA-1, None) , ( cell line: COS cells, None) , ( protein: ER, None) " }

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{ "id": "39", "sentence": "Mapping experiments indicate that GATA-1 and the ER form at least two contacts, which involve the finger region and the N-terminal activation domain of GATA-1 .", "label": " ( protein: ER, None) , ( protein: GATA-1, None) , ( protein: N-terminal activation domain, None) , ( protein: GATA-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ER, None) , ( protein: GATA-1, None) , ( protein: N-terminal activation domain, None) , ( protein: GATA-1, None) " }

[]

{ "id": "40", "sentence": "We speculate that estrogens exert effects on erythropoiesis by modulating GATA-1 activity through protein-protein interaction with the ER .", "label": " ( protein: GATA-1, None) , ( protein: ER, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GATA-1, None) , ( protein: ER, None) " }

[]

{ "id": "41", "sentence": "(ABSTRACT TRUNCATED AT 250 WORDS)", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "42", "sentence": "Mouse interleukin-2 receptor alpha gene expression .", "label": " ( DNA: Mouse interleukin-2 receptor alpha gene, None) , ( protein: interleukin-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: Mouse interleukin-2 receptor alpha gene, None) , ( protein: interleukin-2, None) " }

[]

{ "id": "43", "sentence": "Interleukin-1 and interleukin-2 control transcription via distinct cis-acting elements .", "label": " ( protein: Interleukin-1, None) , ( DNA: cis-acting elements, None) , ( protein: interleukin-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Interleukin-1, None) , ( DNA: cis-acting elements, None) , ( protein: interleukin-2, None) " }

[]

{ "id": "44", "sentence": "We have shown that interleukin-1 ( IL-1 ) and IL-2 control IL-2 receptor alpha ( IL-2R alpha ) gene transcription in CD4-CD8- murine T lymphocyte precursors .", "label": " ( protein: interleukin-1, None) , ( protein: IL-1, None) , ( protein: IL-2R alpha, None) , ( protein: IL-2 receptor alpha, None) , ( DNA: IL-2 receptor alpha ( IL-2R alpha ) gene, None) , ( protein: IL-2, None) , ( cell line: CD4-CD8- murine T lymphocyte precursors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: interleukin-1, None) , ( protein: IL-1, None) , ( protein: IL-2R alpha, None) , ( protein: IL-2 receptor alpha, None) , ( DNA: IL-2 receptor alpha ( IL-2R alpha ) gene, None) , ( protein: IL-2, None) , ( cell line: CD4-CD8- murine T lymphocyte precursors, None) " }

[]

{ "id": "45", "sentence": "Here we map the cis-acting elements that mediate interleukin responsiveness of the mouse IL-2R alpha gene using a thymic lymphoma-derived hybridoma ( PC60 ).", "label": " ( cell line: thymic lymphoma-derived hybridoma, None) , ( cell line: PC60, None) , ( protein: mouse IL-2R alpha, None) , ( DNA: cis-acting elements, None) , ( DNA: mouse IL-2R alpha gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: thymic lymphoma-derived hybridoma, None) , ( cell line: PC60, None) , ( protein: mouse IL-2R alpha, None) , ( DNA: cis-acting elements, None) , ( DNA: mouse IL-2R alpha gene, None) " }

[]

{ "id": "46", "sentence": "The transcriptional response of the IL-2R alpha gene to stimulation by IL-1 + IL-2 is biphasic.", "label": " ( DNA: IL-2R alpha gene, None) , ( protein: IL-1, None) , ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: IL-2R alpha gene, None) , ( protein: IL-1, None) , ( protein: IL-2, None) " }

[]

{ "id": "47", "sentence": "IL-1 induces a rapid, protein synthesis-independent appearance of IL-2R alpha mRNA that is blocked by inhibitors of NF-kappa B activation .", "label": " ( protein: IL-2R alpha, None) , ( protein: IL-1, None) , ( protein: NF-kappa B, None) , ( RNA: IL-2R alpha mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2R alpha, None) , ( protein: IL-1, None) , ( protein: NF-kappa B, None) , ( RNA: IL-2R alpha mRNA, None) " }

[]

{ "id": "48", "sentence": "It also primes cells to become IL-2 responsive and thereby prepares the second phase, in which IL-2 induces a 100-fold further increase in IL-2R alpha transcripts .", "label": " ( RNA: IL-2R alpha transcripts, None) , ( protein: IL-2R alpha, None) , ( protein: IL-2, None) , ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: IL-2R alpha transcripts, None) , ( protein: IL-2R alpha, None) , ( protein: IL-2, None) , ( protein: IL-2, None) " }

[]

{ "id": "49", "sentence": "Transient transfection experiments show that several elements in the promoter-proximal region of the IL-2R alpha gene contribute to IL-1 responsiveness, most importantly an NF-kappa B site conserved in the human and mouse gene .", "label": " ( DNA: NF-kappa B site, None) , ( protein: NF-kappa B, None) , ( DNA: IL-2R alpha gene, None) , ( protein: IL-2R alpha, None) , ( protein: IL-1, None) , ( DNA: promoter-proximal region, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: NF-kappa B site, None) , ( protein: NF-kappa B, None) , ( DNA: IL-2R alpha gene, None) , ( protein: IL-2R alpha, None) , ( protein: IL-1, None) , ( DNA: promoter-proximal region, None) " }

[]

{ "id": "50", "sentence": "IL-2 responsiveness , on the other hand, depends on a 78-nucleotide segment 1.3 kilobases upstream of the major transcription start site .", "label": " ( DNA: major transcription start site, None) , ( protein: IL-2, None) , ( DNA: 78-nucleotide segment, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: major transcription start site, None) , ( protein: IL-2, None) , ( DNA: 78-nucleotide segment, None) " }

[]

{ "id": "51", "sentence": "This segment functions as an IL-2-inducible enhancer and lies within a region that becomes DNase I hypersensitive in normal T cells in which IL-2R alpha expression has been induced.", "label": " ( protein: DNase I, None) , ( DNA: IL-2-inducible enhancer, None) , ( protein: IL-2R alpha, None) , ( cell type: T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: DNase I, None) , ( DNA: IL-2-inducible enhancer, None) , ( protein: IL-2R alpha, None) , ( cell type: T cells, None) " }

[]

{ "id": "52", "sentence": "IL-2 responsiveness requires three distinct elements within the enhancer .", "label": " ( DNA: enhancer, None) , ( protein: IL-2, None) , ( DNA: elements, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: enhancer, None) , ( protein: IL-2, None) , ( DNA: elements, None) " }

[]

{ "id": "53", "sentence": "Two of these are potential binding sites for STAT proteins .", "label": " ( protein: STAT proteins, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: STAT proteins, None) " }

[]

{ "id": "54", "sentence": "Hematopoietic lineage commitment : role of transcription factors .", "label": " ( cell type: Hematopoietic lineage, None) , ( protein: transcription factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: Hematopoietic lineage, None) , ( protein: transcription factors, None) " }

[]

{ "id": "55", "sentence": "This review focuses on the roles of transcription factors in hematopoietic lineage commitment .", "label": " ( protein: transcription factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factors, None) " }

[]

{ "id": "56", "sentence": "A brief introduction to lineage commitment and asymmetric cell division is followed by a discussion of several methods used to identify transcription factors important in specifying hematopoietic cell types .", "label": " ( cell type: hematopoietic cell types, None) , ( protein: transcription factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: hematopoietic cell types, None) , ( protein: transcription factors, None) " }

[]

{ "id": "57", "sentence": "Next is presented a discussion of the use of embryonic stem cells in the analysis of hematopoietic gene expression and the use of targeted gene disruption to analyze the role of transcription factors in hematopoiesis .", "label": " ( cell type: embryonic stem cells, None) , ( protein: transcription factors, None) , ( DNA: hematopoietic gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: embryonic stem cells, None) , ( protein: transcription factors, None) , ( DNA: hematopoietic gene, None) " }

[]

{ "id": "58", "sentence": "Finally, the status of our current knowledge concerning the roles of transcription factors in the commitment to erythroid , myeloid and lymphoid cell types is summarized.", "label": " ( protein: transcription factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factors, None) " }

[]

{ "id": "59", "sentence": "Epstein-Barr virus replicative gene transcription during de novo infection of human thymocytes : simultaneous early expression of BZLF-1 and its repressor RAZ .", "label": " ( cell type: human thymocytes, None) , ( protein: RAZ, None) , ( protein: BZLF-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: human thymocytes, None) , ( protein: RAZ, None) , ( protein: BZLF-1, None) " }

[]

{ "id": "60", "sentence": "Epstein-Barr virus ( EBV ) is known to infect B cells and epithelial cells .", "label": " ( cell type: B cells, None) , ( cell type: epithelial cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: B cells, None) , ( cell type: epithelial cells, None) " }

[]

{ "id": "61", "sentence": "We and others have shown that EBV can also infect a subset of thymocytes .", "label": " ( cell type: thymocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: thymocytes, None) " }

[]

{ "id": "62", "sentence": "Infection of thymocytes was accompanied by the appearance of linear EBV genome within 8 hr of infection.", "label": " ( DNA: linear EBV genome, None) , ( cell type: thymocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: linear EBV genome, None) , ( cell type: thymocytes, None) " }

[]

{ "id": "63", "sentence": "Circularization of the EBV genome was not detected.", "label": " ( DNA: EBV genome, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: EBV genome, None) " }

[]

{ "id": "64", "sentence": "This is in contrast to the infection in B cells where the genome can circularize within 24 hr of infection.", "label": " ( cell type: B cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: B cells, None) " }

[]

{ "id": "65", "sentence": "The appearance of the BamHI ZLF-1 gene product , ZEBRA , by RT-PCR , was observed within 8 hr of infection.", "label": " ( protein: ZEBRA, None) , ( protein: BamHI ZLF-1 gene product, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ZEBRA, None) , ( protein: BamHI ZLF-1 gene product, None) " }

[]

{ "id": "66", "sentence": "The appearance of a novel fusion transcript ( RAZ ), which comprised regions of the BZLF-1 locus and the adjacent BRLF-1 locus , was detected by RT-PCR .", "label": " ( protein: BZLF-1, None) , ( protein: RAZ, None) , ( protein: fusion transcript, None) , ( DNA: BZLF-1 locus, None) , ( DNA: BRLF-1 locus, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: BZLF-1, None) , ( protein: RAZ, None) , ( protein: fusion transcript, None) , ( DNA: BZLF-1 locus, None) , ( DNA: BRLF-1 locus, None) " }

[]

{ "id": "67", "sentence": "ZEBRA protein was also identified in infected thymocytes by immunoprecipitation .", "label": " ( protein: ZEBRA, None) , ( protein: ZEBRA protein, None) , ( cell type: thymocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ZEBRA, None) , ( protein: ZEBRA protein, None) , ( cell type: thymocytes, None) " }

[]

{ "id": "68", "sentence": "In addition, we demonstrated that the EBNA-1 gene in infected thymocytes was transcribed from the Fp promoter , rather than from the Cp/Wp promoter which is used in latently infected B cells .", "label": " ( DNA: EBNA-1 gene, None) , ( DNA: Cp/Wp promoter, None) , ( cell type: B cells, None) , ( DNA: Fp promoter, None) , ( cell type: latently infected B cells, None) , ( protein: EBNA-1, None) , ( cell type: thymocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: EBNA-1 gene, None) , ( DNA: Cp/Wp promoter, None) , ( cell type: B cells, None) , ( DNA: Fp promoter, None) , ( cell type: latently infected B cells, None) , ( protein: EBNA-1, None) , ( cell type: thymocytes, None) " }

[]

{ "id": "69", "sentence": "Transcripts encoding gp350/220 , the major coat protein of EBV , were identified, but we did not find any evidence of transcription from the LMP-2A or EBER-1 loci in infected thymocytes .", "label": " ( DNA: LMP-2A, None) , ( DNA: EBER-1 loci, None) , ( cell type: thymocytes, None) , ( protein: major coat protein, None) , ( protein: gp350/220, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: LMP-2A, None) , ( DNA: EBER-1 loci, None) , ( cell type: thymocytes, None) , ( protein: major coat protein, None) , ( protein: gp350/220, None) " }

[]

{ "id": "70", "sentence": "These observations suggest that de novo EBV infection of thymocytes differs from infection of B cells .", "label": " ( cell type: thymocytes, None) , ( cell type: B cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: thymocytes, None) , ( cell type: B cells, None) " }

[]

{ "id": "71", "sentence": "The main difference is that with thymocytes , no evidence could be found that the virus ever circularizes.", "label": " ( cell type: thymocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: thymocytes, None) " }

[]

{ "id": "72", "sentence": "Rather, EBV remains in a linear configuration from which replicative genes are transcribed.", "label": " ( DNA: replicative genes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: replicative genes, None) " }

[]

{ "id": "73", "sentence": "Identification and purification of human Stat proteins activated in response to interleukin-2 .", "label": " ( protein: human Stat proteins, None) , ( protein: interleukin-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: human Stat proteins, None) , ( protein: interleukin-2, None) " }

[]

{ "id": "74", "sentence": "A key cytokine induced during the immune response is IL-2 .", "label": " ( protein: IL-2, None) , ( protein: cytokine, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2, None) , ( protein: cytokine, None) " }

[]

{ "id": "75", "sentence": "Following T cell activation , the genes encoding IL-2 and the various chains of its receptor are transcriptionally induced.", "label": " ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2, None) " }

[]

{ "id": "76", "sentence": "In turn, secreted IL-2 serves to stimulate the proliferation and differentiation of T lymphocytes .", "label": " ( protein: IL-2, None) , ( cell type: T lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2, None) , ( cell type: T lymphocytes, None) " }

[]

{ "id": "77", "sentence": "Several recent studies have implicated Jak kinases in the signaling pathway induced by IL-2 .", "label": " ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2, None) " }

[]

{ "id": "78", "sentence": "Following this lead, we set out to identify transcription factors induced in response to IL-2 .", "label": " ( protein: transcription factors, None) , ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factors, None) , ( protein: IL-2, None) " }

[]

{ "id": "79", "sentence": "Human peripheral blood lymphocytes were observed to contain several IL-2 -inducible DNA binding activities .", "label": " ( protein: IL-2, None) , ( cell type: Human peripheral blood lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2, None) , ( cell type: Human peripheral blood lymphocytes, None) " }

[]

{ "id": "80", "sentence": "Similar activities were also observed in a transformed human lymphocyte line , termed YT .", "label": " ( cell line: YT, None) , ( cell line: transformed human lymphocyte line, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: YT, None) , ( cell line: transformed human lymphocyte line, None) " }

[]

{ "id": "81", "sentence": "We have purified these activities and found that the principal IL-2 -inducible component bears significant relatedness to a prolactin-induced transcription factor first identified in sheep mammary gland tissue .", "label": " ( protein: prolactin-induced transcription factor, None) , ( cell type: sheep mammary gland tissue, None) , ( protein: IL-2, None) , ( protein: IL-2 -inducible component, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: prolactin-induced transcription factor, None) , ( cell type: sheep mammary gland tissue, None) , ( protein: IL-2, None) , ( protein: IL-2 -inducible component, None) " }

[]

{ "id": "82", "sentence": "We hypothesize that activation of this protein, designated hStat5 , helps govern the biological effects of IL-2 during the immune response .", "label": " ( protein: hStat5, None) , ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: hStat5, None) , ( protein: IL-2, None) " }

[]

{ "id": "83", "sentence": "E2F-1 and a cyclin-like DNA repair enzyme , uracil-DNA glycosylase , provide evidence for an autoregulatory mechanism for transcription .", "label": " ( protein: uracil-DNA glycosylase, None) , ( protein: E2F-1, None) , ( protein: cyclin-like DNA repair enzyme, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: uracil-DNA glycosylase, None) , ( protein: E2F-1, None) , ( protein: cyclin-like DNA repair enzyme, None) " }

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{ "id": "84", "sentence": "The cell cycle-dependent transcription factor , E2F-1 , regulates the cyclin -like species of the DNA repair enzyme uracil-DNA glycosylase ( UDG ) gene in human osteosarcoma ( Saos-2 ) cells .", "label": " ( DNA: uracil-DNA glycosylase ( UDG ) gene, None) , ( cell line: Saos-2, None) , ( protein: DNA repair enzyme, None) , ( protein: E2F-1, None) , ( protein: uracil-DNA glycosylase, None) , ( protein: UDG, None) , ( cell line: human osteosarcoma ( Saos-2 ) cells, None) , ( protein: cyclin, None) , ( protein: cell cycle-dependent transcription factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: uracil-DNA glycosylase ( UDG ) gene, None) , ( cell line: Saos-2, None) , ( protein: DNA repair enzyme, None) , ( protein: E2F-1, None) , ( protein: uracil-DNA glycosylase, None) , ( protein: UDG, None) , ( cell line: human osteosarcoma ( Saos-2 ) cells, None) , ( protein: cyclin, None) , ( protein: cell cycle-dependent transcription factor, None) " }

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{ "id": "85", "sentence": "We demonstrate, through the deletion of the human UDG promoter sequences , that expression of E2F-1 activates the UDG promoter through several E2F sites .", "label": " ( DNA: E2F sites, None) , ( protein: UDG, None) , ( DNA: UDG promoter, None) , ( protein: E2F-1, None) , ( protein: UDG, None) , ( DNA: human UDG promoter sequences, None) , ( protein: E2F, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: E2F sites, None) , ( protein: UDG, None) , ( DNA: UDG promoter, None) , ( protein: E2F-1, None) , ( protein: UDG, None) , ( DNA: human UDG promoter sequences, None) , ( protein: E2F, None) " }

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{ "id": "86", "sentence": "The major putative downstream site for E2F , located in the first exon , serves as a target for E2F-1/DP1 complex binding in vitro.", "label": " ( DNA: major putative downstream site, None) , ( protein: E2F, None) , ( protein: E2F-1/DP1 complex, None) , ( DNA: first exon, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: major putative downstream site, None) , ( protein: E2F, None) , ( protein: E2F-1/DP1 complex, None) , ( DNA: first exon, None) " }

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{ "id": "87", "sentence": "We also provide evidence for the functional relationship between the cyclin-like UDG gene product and E2F .", "label": " ( protein: E2F, None) , ( protein: UDG, None) , ( protein: cyclin-like UDG gene product, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: E2F, None) , ( protein: UDG, None) , ( protein: cyclin-like UDG gene product, None) " }

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{ "id": "88", "sentence": "High levels of UDG expression in a transient transfection assay result in the down-regulation of transcriptional activity through elements specific for E2F -mediated transcription .", "label": " ( protein: UDG, None) , ( protein: E2F, None) , ( DNA: elements, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: UDG, None) , ( protein: E2F, None) , ( DNA: elements, None) " }

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{ "id": "89", "sentence": "Overexpression of UDG in Saos 2 cells was observed to delay growth late in G1 phase and transiently arrest these cells from progressing into the S phase .", "label": " ( cell line: Saos 2 cells, None) , ( protein: UDG, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: Saos 2 cells, None) , ( protein: UDG, None) " }

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{ "id": "90", "sentence": "This hypothetical model integrates one mechanism of DNA repair with the cell cycle control of gene transcription , likely through E2F .", "label": " ( protein: E2F, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: E2F, None) " }

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{ "id": "91", "sentence": "This implicates E2F as a multifunctional target for proteins and enzymes, possibly, responsive to DNA damage through the negative effect of UDG on E2F -mediated transcriptional activity .", "label": " ( protein: E2F, None) , ( protein: E2F, None) , ( protein: UDG, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: E2F, None) , ( protein: E2F, None) , ( protein: UDG, None) " }

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{ "id": "92", "sentence": "Cellular and molecular mechanisms of IFN-gamma production induced by IL-2 and IL-12 in a human NK cell line .", "label": " ( cell line: human NK cell line, None) , ( protein: IL-12, None) , ( protein: IFN-gamma, None) , ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: human NK cell line, None) , ( protein: IL-12, None) , ( protein: IFN-gamma, None) , ( protein: IL-2, None) " }

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{ "id": "93", "sentence": "Interferon-gamma ( IFN-gamma ) is an important immunoregulatory protein produced predominantly by T cells and large granular lymphocytes ( LGL ) in response to different extracellular signals .", "label": " ( protein: IFN-gamma, None) , ( cell type: T cells, None) , ( protein: Interferon-gamma, None) , ( cell type: large granular lymphocytes, None) , ( cell type: LGL, None) , ( protein: immunoregulatory protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IFN-gamma, None) , ( cell type: T cells, None) , ( protein: Interferon-gamma, None) , ( cell type: large granular lymphocytes, None) , ( cell type: LGL, None) , ( protein: immunoregulatory protein, None) " }

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{ "id": "94", "sentence": "In particular, two interleukins ( ILs ), IL-2 and IL-12 , have been shown to be potent inducers of IFN-gamma gene expression in both T cells and LGL .", "label": " ( protein: ILs, None) , ( protein: IL-12, None) , ( protein: interleukins, None) , ( protein: IL-2, None) , ( cell type: LGL, None) , ( protein: IFN-gamma, None) , ( cell type: T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ILs, None) , ( protein: IL-12, None) , ( protein: interleukins, None) , ( protein: IL-2, None) , ( cell type: LGL, None) , ( protein: IFN-gamma, None) , ( cell type: T cells, None) " }

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{ "id": "95", "sentence": "Although it has been reported that there are some T cell lines that produce IFN-gamma in response to IL-2 and IL-12 stimulation , there has as yet been no report of a natural killer (NK) cell line that responds in a similar manner.", "label": " ( cell line: natural killer (NK) cell line, None) , ( protein: IFN-gamma, None) , ( cell line: T cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: natural killer (NK) cell line, None) , ( protein: IFN-gamma, None) , ( cell line: T cell lines, None) " }

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{ "id": "96", "sentence": "In this report we present evidence that the cell line NK3.3 derived from human NK cells , responds to both IL-2 and IL-12 , as measured by increases in IFN-gamma and granulocyte-macrophage colony-stimulating factor ( GM-CSF ) cytoplasmic mRNA and protein expression .", "label": " ( protein: GM-CSF, None) , ( protein: IFN-gamma, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) , ( cell type: human NK cells, None) , ( protein: IL-12, None) , ( protein: IL-2, None) , ( cell line: cell line NK3.3, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GM-CSF, None) , ( protein: IFN-gamma, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) , ( cell type: human NK cells, None) , ( protein: IL-12, None) , ( protein: IL-2, None) , ( cell line: cell line NK3.3, None) " }

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{ "id": "97", "sentence": "In addition, when used together IL-2 and IL-12 synergized in the induction of IFN-gamma and GM-CSF and this synergy was attributed to an increased accumulation and stability of the IFN-gamma and GM-CSF mRNAs .", "label": " ( protein: IL-12, None) , ( RNA: GM-CSF mRNAs, None) , ( protein: IFN-gamma, None) , ( protein: IL-2, None) , ( RNA: IFN-gamma and GM-CSF mRNAs, None) , ( protein: GM-CSF, None) , ( protein: GM-CSF, None) , ( protein: IFN-gamma, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-12, None) , ( RNA: GM-CSF mRNAs, None) , ( protein: IFN-gamma, None) , ( protein: IL-2, None) , ( RNA: IFN-gamma and GM-CSF mRNAs, None) , ( protein: GM-CSF, None) , ( protein: GM-CSF, None) , ( protein: IFN-gamma, None) " }

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{ "id": "98", "sentence": "To investigate the signaling pathways involved in the gene induction, five inhibitors, cyclosporin A ( CsA ), transforming growth factor-beta , cycloheximide , genistein , and staurosporine A , were used in analyzing the effects of IL-2 and IL-12 on NK3.3 cells .", "label": " ( protein: transforming growth factor-beta, None) , ( cell line: NK3.3 cells, None) , ( protein: IL-2, None) , ( protein: IL-12, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transforming growth factor-beta, None) , ( cell line: NK3.3 cells, None) , ( protein: IL-2, None) , ( protein: IL-12, None) " }

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{ "id": "99", "sentence": "The results suggest that activation of protein kinase C , but not new protein synthesis , is required for IL-2 induction of IFN-gamma and GM-CSF cytoplasmic mRNA .", "label": " ( protein: protein kinase C, None) , ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: protein kinase C, None) , ( protein: IL-2, None) " }