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Trigonelline inhibits caspase 3 to protect β cells apoptosis in streptozotocin-induced type 1 diabetic mice. As a main active ingredient of Fenugreek, trigonelline has protective efficiency on type 2 diabetes and diabetic peripheral neuropathy in rats. This study investigates the protection of trigonelline on hyperglycemia, β cell apoptosis, and inflammation in type 1 diabetic mice. Streptozotocin (160 mg/kg) was intraperitoneal injected to induce diabetic mice. There were 4 groups: normal control, diabetes, trigonelline-treated diabetes, and insulin-treated diabetes. After 4-week treatment, levels of blood glucose, serum insulin, and inflammatory factors, β cell apoptosis, insulin content, and oxidative stress parameters in pancreas were calculated. Pancreas was examined by immunohistochemistry staining and hematoxylin/eosin. Trigonelline significantly declined the levels of blood glucose, serum tumor necrosis factor-α, interleukin-6, and interleukin-1β, while increased the levels of serum insulin and adiponectin in diabetic mice. Insulin content, glutathione concentration, serum activities of superoxide dismutase and catalase in pancreas, and pancreas to body weight ratio were remarkably decreased, while serum malondialdehyde concentration was increased in diabetic mice. Trigonelline treatment restored the above mentioned parameters. Trigonelline even suppresses β cell apoptosis via downregulating caspase 3 expression. These results imply that trigonelline protects diabetic mice mediated by decreasing blood glucose, increasing insulin expression in β cells, regulating inflammatory response, suppressing β cells apoptosis partly by downregulating caspase 3 expression, and raising antioxidant enzyme activity.

2024-01-13T01:27:04.277712

https://example.com/article/6324

Q: Complicated query in mysql database I have two Tables: **user** idU - autoincrement name **automobile** idA - autoincrement id_user value date - type: yyyy-mm-dd Each user has many automobile A automobile has only one user Currently i am using the following query for all users(5 in total): select sum(value) as user_value, name from user inner join automobile on user.idU = automobile.id_user where name like ? AND date = ? what i want? I want the total value of all user in specific date using 1 query. how can i do this? @edit1: TABLE USER --idU------name---- 1 mateus 2 joao 3 maria TABLE AUTOMOBILE --idA---id_user----value-------date------ 1 1 250 2013-10-13 2 3 322 2013-10-13 3 1 150 2013-10-13 4 3 80 2013-10-13 5 2 100 2013-11-13 6 3 500 2013-11-13 7 1 1100 2013-11-13 8 1 50 2013-12-13 9 3 135 2013-12-13 10 2 40 2013-12-13 I request a query with date = 2013-10-13 and it return: ---name---value mateus 400 maria 422 A: Something like: select sum(value) as user_value, name inner join automobile on user.idU = automobile.id_user where date = ? group by user.idU -----------EDIT------------ select name, sum(value) as value from user inner join automobile on user.idU = automobile.id_user where date = "2013-10-13" group by automobile.id_user SQLFiddle here: http://sqlfiddle.com/#!2/8115c/4

2023-12-08T01:27:04.277712

https://example.com/article/1580

Q: Cartesian coordinates of the points on the plane in the same order as the Ulam Spiral I'm messing around with doing a visualization that has nothing to do with the primes and in order to execute it correctly I need an ordered list of all point in the order that the Ulam Spiral crosses them. I've tried some of my work but have only run in to abundantly complicated paths to solution. Also is there a name for looking for pattern that generally occur in spiral, whether they are related to primes or not? E.g.: Starting with this image: if $1$ is at the origin, then the list would be as follows: $$(0,0),(1,0),(1,1),(0,1),(-1,1),(-1,0),(-1,-1),(0,-1),(1,-1),‌​(2,-1),(2,0),...$$ A: You are lucky because it seems that a very similar pair of sequences is already at OEIS. The $x$-coordinates are sequence A174344 ("List of $x$-coordinates of point moving in clockwise spiral") and $y$-coordinates ("List of $y$-coordinates of point moving in clockwise spiral") are sequence A268038. List of $x$-coordinates of point moving in clockwise spiral. $$0, 1, 1, 0, -1, -1, -1, 0, 1, 2, 2, 2, 2, 1, 0, -1, -2, -2, -2, -2, -2, -1, 0, 1, 2, 3, 3, 3, 3, 3, 3, 2, 1, 0, -1, -2, -3, -3, -3, -3, -3, -3, -3, -2, -1, 0, 1, 2, 3, 4, 4, 4, 4, 4, 4, 4, 4, 3, 2, 1, 0, -1, -2, -3, -4, -4, -4, -4, -4, -4, -4, -4, -4, -3, -2, \cdots$$ List of $y$-coordinates of point moving in clockwise spiral. $$0, 0, -1, -1, -1, 0, 1, 1, 1, 1, 0, -1, -2, -2, -2, -2, -2, -1, 0, 1, 2, 2, 2, 2, 2, 2, 1, 0, -1, -2, -3, -3, -3, -3, -3, -3, -3, -2, -1, 0, 1, 2, 3, 3, 3, 3, 3, 3, 3, 3, 2, 1, 0, -1, -2, -3, -4, -4, -4, -4, -4, -4, -4, -4, -4, -3, -2, -1, 0, 1, 2, 3, 4, 4, 4, \cdots$$ In the referred OEIS pages there are formulas to calculate each sequence of coordinates.

2023-08-06T01:27:04.277712

https://example.com/article/9210

clean energy Archive “Scottish government approves offshore wind farm bitterly opposed by Donald Trump“ Which of the following makes more sense: A Luxury Hotel to increase traffic, and profits, to Donald Trumps holdings, or a Wind Farm consisting of 11 turbines which could …

2024-02-25T01:27:04.277712

https://example.com/article/3556

Former White House press secretary Sean Spicer made a surprise cameo appearance at the 69th Emmys and helped Stephen Colbert mock his old boss President Trump. He was wheeled out on a White House-esq podium and re-created his now infamous Trump inauguration claim that it was biggest attendance in history. Spicer appeared after Colbert unleashed a blistering string of jabs about Trump, calling him a 'morally corrupt anti-hero,' a 'whiter Walter White', poking fun at his obsession with ratings and tweeting. The Late Show host also performed a song which included the lyrics 'treason is better on TV', while flashing a shot of Trump and Vladimir Putin, and 'Imagine if your president was not beloved by Nazis'. He also took a shot at his failure to win the popular vote during the election. Spicer and Colbert were joined by a long line of celebrities who criticized the president and his policies throughout the three-hour CBS broadcast, where politics was placed firmly in the spotlight. Jane Fonda called him a bigot, Alec Baldwin ridiculed his failure to win an Emmy, Donald Glover he accused him of oppressing black people and Julia Louis-Dreyfus made an impeachment joke. Scroll for video Sean Spicer was wheeled out during Stephen Colbert's opening monologue to the shock of celebrities sitting in the audience at the Microsoft Theater in LA Sunday Stephen Colbert cracked that if Donald Trump had gotten an Emmy for 'The Apprentice' maybe he wouldn't have run for President McCarthy was surprised to see her SNL 'doppelganger' wheeled onstage. She led the star-studded audience in their shock at the former press secretary's cameo Veep star Anna Chlumsky's face summed up the audience's reaction as Spicer was wheeled onstage behind the podium EVERY JOKE AND JAB AT TRUMP AT THE EMMYS Colbert's opening monologue took a more benevolent turn when he urged people to keep donations coming to those in need after hurricanes ravaged both Florida and Texas STEPHEN COLBERT 'Of course, there's no way anyone could possibly watch that much TV, other than the president, who seems to have a lot of time for that sort of thing. Hello sir, thank you for joining us! Looking forward to the tweets. 'We know that the biggest TV star of the last year is Donald Trump. No, we may not like it, but he's the biggest star. And you know, Alec Baldwin, obviously. You guys are neck and neck. And Alec, you're up against a lot of neck. 'However you feel about the president, and you do feel about the president, you can't deny that every show was influenced by Donald Trump in some way. 'All the late night shows, obviously, 'House of Cards,' the new season of 'American Horror Story'. 'We all know that the Emmys mean a lot to Donald Trump because he was nominated multiple times for 'Celebrity Apprentice,' but he never won. Why didn't you give him an Emmy? I'll tell you this — if he had won an Emmy, I bet he wouldn't have run for president. So this is all your fault. I thought you people love morally compromised antiheroes. You like Walter White. 'And he never forgave you, and he never will. The president has complained repeatedly that the Emmys are rigged. He even went after the host a few years back, tweeting, 'That Seth Meyers is hosting the Emmy Awards is a total joke. He is very awkward with almost no talent. Marbles in his mouth!' Wow, marbles in his mouth, that's harsh. That's quite an accusation, do you have a response Seth? (Camera pans to Meyers, with marbles falling out of his mouth). 'And even during the campaign, he wouldn't let it go. This actually happened, this exchange actually happened in the debates. (Goes to video showing Clinton mentioning Trump's Emmy loss in debate) 'But he didn't. Because unlike the presidency, Emmys go to the winner of the popular vote. Where do I find the courage to tell that joke in this room? Of course, what really matters to Donald Trump is ratings. He's got to have the big numbers, and I certainly hope we achieve that tonight. 'Unfortunately, at this point, we have no way of knowing how big our audience is. I mean, is there anyone who could say how big the audience is? Sean, do you know? (Moment Sean Spicer comes out on podium). 'The Americans has hotter spies than the Russia inquiry, even treason's better on TV' In a skit spoofing HBO hit, Westworld, Colbert was asked by Jeffrey Wright if he's 'ever questioned the nature of [his] reality?' Colbert responds: 'Every day since November 8th.' SEAN SPICER 'This will be the largest audience to witness an Emmys. Period. Both in person, and around the world.' Sean Spicer in a nod to the former WH flack's now infamous claim President Trump's crowd was the largest in history.' COLBERT RESPONDS: 'Wow, that really soothes my fragile ego. I can understand why you'd want one of these guys around. Melissa McCarthy everyone, give it up! Beautiful.' 'Imagine if your president wasn't loved by Nazis' Veep star Louis-Dreyfus sang during the show's opening song JULIA LOUIS-DREYFUS 'Imagine if your president wasn't loved by Nazis' Louis-Dreyfus sang during the show's opening song. 'We did have a whole story line about an impeachment but we abandoned that because we were worried that someone else might get to it first.' ALEC BALDWIN 'I suppose I should say, at long last, Mr. President, here is your Emmy,' Baldwin said while accepting the award for his portrayal of the President on SNL. 'Orange wig proved to be effective' birth control, cracked Baldwin during his acceptance speech after he said he and wife Hilaria haven't had a child in three years. JANE FONDA, LILY TOMLIN AND DOLLY PARTON 'Back in 1980 in that movie (9 to 5), we refused to be controlled by a sexist, egotistical, lying, hypocritical bigot. 'And in 2017, we still refuse to be controlled by a sexist, egotistical, lying, hypocritical bigot.' DONALD GLOVER Glover 'thanked' Trump for 'making black people number one on the most oppressed list' during one of his Emmys acceptance speeches. 'He's the reason I'm probably up here,' he added. JOHN LITHGOW 'First and foremost, I want to thank Winston Churchill. In these crazy times, his life reminds us what courage and leadership in government looks like.' KUMAIL NANJIANI 'They (the nominees for Outstanding Reality-Competition Program) also celebrate people who frantically race across international borders, and those who can scale walls really, really quickly. In other words, the president's worst nightmare.' SETH MYERS The late night hoset took on physical comedy as Trump had previously called him 'marble mouthed' when he was hosting in 2014 on Twitter. The tweet flashed on screen as cameras cut to Meyers drooling marbles Advertisement Politics even made its way into the winners. The Handmaid's Tale with took home six goings for its bleak portrait of an authoritarian America. The glitzy ceremony in downtown Los Angeles - the first under the administration of President Donald Trump - was widely expected to have a strongly political flavor. 'However you feel about the president, and you do feel about the president, you can't deny that every show was influenced by Donald Trump in some way,' Colbert began. 'All the late night shows, obviously, 'House of Cards,' the new season of 'American Horror Story.'' This will be the largest audience to witness an Emmys. Period. Both in person, and around the world Sean Spicer But it was Spicer's cameo that drew the most shocked reaction. As he appeared 'Spicey' cracked 'This will be the largest audience to witness an Emmys. Period. Both in person, and around the world.' Spicer was brought out to a surprised room full of celebrities whose jaws dropped when they saw the president's former mouth piece at the Microsoft Theater in LA. As the former White House flack was wheeled offstage, Colbert said 'Thank you Melissa McCarthy!' a nod to the actress's fantastic impersonation of Spicer on Saturday Night Live. Colbert also jokingly scolded Emmy voters for not giving Trump an Emmy for 'The Apprentice,' posing that maybe if he had his own an Emmy he wouldn't have run for President. 'I thought you guys loved morally compromised antiheroes,' he said of Trump, then called him 'Walter Whiter,' in reference to the 'Breaking Bad' character who won several Emmys for Bryan Cranston. He also hilariously noted: 'Unlike the presidency, Emmys go to the winner of the popular vote.' The awards show put Trump's seeming obsession with the Emmys front and center when they showed his 2012 tweet in which he shared his dismay over his reality show 'The Apprentice' not scoring the coveted golden statue Did he make it out alive? Spicer has caught the ire of Hollywood while managing to become the butt of jokes after his run as press secretary - but he was happy to pose up with various celebrities - including the one who mocks his boss Baldwin slammed Trump for his unsuccessful Emmy nominations in the past for The Apprentice - while he picked up the Best Supporting Actor award for his impression of the president on Saturday Night Live Spicer also got a picture with Emmys host Stephen Colbert, who made several jabs at Trump throughout the night, Dolly Parton and James Corden - who planted a kiss on his cheek The president in 2012 vented his frustrations after his reality show The Apprentice did not get one of the coveted gold statues given at the Emmys. 'The Emmys are all politics, that's why, despite nominations, The Apprentice never won--even though it should have many times over,' Trump tweeted at the time. During a spirited opening song with several celebrity appearances, Julia Louis-Dreyfus sang how nice it would be to have a president who 'was not beloved by Nazis.' Unlike the presidency, Emmys go to the winner of the popular vote Stephen Colbert With Colbert chiming in 'Even treason's better on TV,' as an image flashes of Vladimir Putin and Donald Trump. Later in a skit spoofing HBO hit, Westworld, Colbert was asked by Jeffrey Wright if he's 'ever questioned the nature of [his] reality?' Colbert responds: 'Every day since November 8th.' Trump was not the only politician who was found in the cross hairs of Colbert's deadpan delivery. Texas Senator Ted Cruz was just caught up in a scandal where his Twitter account 'liked' a hardcore porn video. Colbert did not miss the opportunity to bring the mishap into his opening diatribe. When talking about the myriad of steaming services available, the host jested: 'These days everyone loves streaming video, just ask Ted Cruz, but knock first. You don't wanna just walk in.' The host did take time out from berating Republicans to thank first responders for their contributions during Hurricane Irene and Hurricane Harvey which devastated Florida and Texas respectively. 'While we're thanking people, no one deserves more thanks than our first responders', he said. 'They have been working tirelessly following the disasters in Texas and Florida' adding that there is still time to donate to the efforts in the neighborhoods hit hardest by the natural disasters. Marble mouthed 2014 Emmy host: Trump called Seth Meyers hosting gig a 'total joke' in 2012 when he was upset he didn't win an Emmy for 'The Apprentice.' Colbert flashed Trump's tweet as Meyers drooled marbles out of his mouth Loser no more? Trump didn't win an Emmy for his show The Apprentice in 2014 taking to his perennial favorite platform Twitter to call Meyers 'very awkward with almost no talent' Alec Baldwin smiled in the audience as Colbert cracked at the actor's impersonation of the president on SNL this season L to R: Stars of tv series '9 to 5' Lily Lily Tomlin, Dolly Parton, Jane Fonda took aim at the president without naming him- comparing him to a character in their 1980's series who was described as a 'sexist, egotistical, lying, hypocritical, bigoted boss' Sean Spicer stole the show during the opening monologue as he shocked the house packed with celebrities, many with who are of the more liberal persuasion Colbert also took aim at Bill Maher for using the N-word during on his HBO show after speaking on the most black nominees ever during this year's awards: 'I assume he's black since he's so comfortable using the N-word. I don't know. Goodnight! That's my time everybody.' However several celebrity presenters and those accepting awards decided to keep the spotlight on Trump, as the hits on his reign kept on coming later in the program. The president has complained repeatedly that the Emmys are rigged. He even went after the host a few years back, tweeting, 'That Seth Meyers is hosting the Emmy Awards is a total joke. He is very awkward with almost no talent. Marbles in his mouth!' Wow, marbles in his mouth, that's harsh. That's quite an accusation, do you have a response Seth? (Marbles fall out of Meyers' mouth). Trump called Seth Meyers Emmy's hosting gig a 'total joke' in 2014. Colbert started off by saying 'He even went after the host a few years back, tweeting, ''That Seth Meyers is hosting the Emmy Awards is a total joke. He is very awkward with almost no talent. Marbles in his mouth!'' Wow, marbles in his mouth, that's harsh. That's quite an accusation, do you have a response Seth?' Cameras cut to Meyers dribbling marbles out of his mouth in response. Baldwin came to the stage accepting the Emmy and started off his speech by saying: 'At long last, Mr. President, here is your Emmy.' After its most-watched season in 23 years, 'Saturday Night Live' won nine Emmys, including best variety sketch series, for actress Kate McKinnon and for Melissa McCarthy's turn as Spicer. Soon after Baldwin picked up the accolade, Jane Fonda, Lily Tomlin and Dolly Parton, came on stage to present an award and made a joke about their 1980s movie 9 to 5, at Trump's expense. Tomlin and Fonda said in 1980 they didn't put up with a 'sexist, egotistical, lying, hypocritical, bigoted boss' and they won't today either, in a clear knock at Trump. Donald Glover won his first Emmy win for Outstanding Directing for a Comedy Series, making him the first black director to ever win the category. Julia Louis Dreyfus, who portrays a POTUS on the HBO show 'Veep' received a round of applause after she joked the show decided to skip an impeachment line as they figured 'someone else might get to it first' Donald Glover accepts Outstanding Directing for a Comedy Series and thanked the president for making blacks in America 'number one on the most oppressed list' He used the speech to make a jibe at the president. Glover 'thanked' Trump for 'making black people number one on the most oppressed list.' Julia Louis Dreyfus who is starring in the hit show 'Veep' as President Selina Meyer on the HBO comedy, jested 'We did have a whole story line about an impeachment but we abandoned that because we were worried that someone else might get to it first.' The joke received a rousing applause from the fairly liberal Hollywood elite crowd. Meanwhile, several celebrities walked the carpet wearing blue ribbons, but it wasn't a new trend. Stars were showing their support for the American Civil Liberties Union and their 'Stand With the ACLU' initiative. 'Saturday Night Live' cast member Kate McKinnon told the audience that playing Hillary Clinton was the greatest honor of her life. McKinnon won outstanding supporting actress in a comedy series Sunday at the Emmy Awards for her work on the sketch comedy show, in which she frequently portrayed Clinton during the Presidential election. Backstage reporters peppered McKinnon with questions about Clinton. McKinnon says she is a great admirer of Clinton and that she is the best role she's ever gotten to play. McKinnon was spotted having dinner with Clinton in New York in February and called the experience surreal and wonderful and says she also ate too much. Sterling K. Brown won best dramatic actor for his role as an African-American who is adopted into a white family in heart-tugging NBC family drama 'This Is Us.' In a crowded limited series category, HBO's murder mystery 'Big Little Lies' came out on top, winning eight Emmys including for best series, for Nicole Kidman's abused wife character, for Laura Dern and Alexander Skarsgard, as well as for writing and directing. Kidman said the show 'was created out of frustration because women weren't getting great roles. So now, more roles for women, please!' Britain's Riz Ahmed beat presumed front-runner Robert De Niro to take his first Emmy for his role as a man who falls foul of the U.S. judicial system in HBO's crime limited series 'The Night Of.' Some of the night's biggest losers included two new Netflix shows. Fan favorite 'Stranger Things' won just five of its 18 nominations, mostly in technical categories, and British royal series 'The Crown' came away with three out of 16 nominations.

2024-01-22T01:27:04.277712

https://example.com/article/8280

Old rovers can indeed learn new tricks. Rolling into its 10th anniversary on the Red Planet, Opportunity has discovered clay minerals showing that life-friendly water flowed on Mars in the earliest epoch of its history. The findings indicate that Curiosity’s groundbreaking discovery last year of clays capable of hosting microbes like those on Earth was no fluke, experts said. “We’ve basically found strong evidence for clays on both sides of the planet,” said Cornell University planetary scientist Steve Squyres, lead scientist for NASA’s Mars Exploration Rover program and coauthor of a report published in Friday’s edition of the journal Science. Opportunity has seen better days since it landed on Mars on Jan. 24, 2004. It has a bad front right wheel, its robotic arm is suffering from mechanical arthritis and it has even had a “senior moment” with its flash memory, Mars Exploration Rover project manager John Callas said in a briefing Thursday. But Opportunity is far from done with Mars. Its discovery of water that’s not too acidic to support life shows that it has a lot more exploring to do as it heads into its second decade, Callas said. “This creates some of the most scientifically interesting opportunities of the entire mission,” Callas said. When Opportunity and its now-defunct twin Spirit landed on the Martian surface, they probed the planet for evidence of water in the past. They found mineral and chemical signs of the liquid’s past existence in the Meridiani Planum area, including spherules -- blueberry-shaped concretions of the mineral hematite -- which are thought to have formed in running water. But many of those chemical clues came in the form of sulfates, a sign of highly acidic water that would not have been able to support life as we know it. Since Opportunity’s arrival at the rim of Endeavour crater in 2011, the picture has changed dramatically, Squyres said. The rover has discovered signs of clay minerals that form in the presence of low-acidity, pH-neutral water. The clay-rich rocks are geographically close to the sulfate-rich rocks, but they were vastly separated by time, Squyres said. In fact, the clays came from a much deeper layer of rock that represented the earliest epoch in Martian history. “These are some of the oldest rocks we’ve looked at — probably the oldest rocks that we’ve looked at with Opportunity,” he said. The analysis suggests that a neutral-water environment existed first, and that the acidic environment came later, according to the study. “The older you look, the better it gets in terms of habitability at this location,” said study leader Raymond Arvidson, a planetary scientist at Washington University in St. Louis. Arvidson pointed to the evidence for neutral water from fractured rocks like one named Esperance, recently studied at a segment along Endeavour’s rim called Cape York. “If I were there back when this material was being emplaced and altered, and I had my summer house, this is where I would drill to get good drinking water,” Arvidson said. Of course, this doesn’t mean that all of Mars was friendly to microbes, and scientists have a long way to go to figure out whether there was ever life at all. That’s a job for a future mission -- say, the Mars 2020 rover, which would cache samples for another spacecraft to bring back to Earth. “These results demonstrate that early Mars was habitable, but this does not mean that Mars was inhabited,” Caltech geologist John Grotzinger, the lead scientist for the Curiosity mission and coauthor of the Science report, wrote in a commentary. “Even for Earth, it was a formidable challenge to prove that microbial life existed billions of years ago.” Unlike Curiosity, a high-tech geology lab on wheels that landed on Mars in 2012, Opportunity can’t directly detect carbon or nitrogen, elements necessary for life as we know it. The elder rover also has no way to determine the age of the materials it encounters. That means it’s impossible to say for sure exactly how old these clay-rich rocks are, or how much later the sulfate-rich rocks emerged. Still, Squyres estimated that the clay-rich rocks are probably somewhere on the order of 4 billion years old, and the sulfate-rich rocks probably came a few hundred million years later. How the environment became more acidic in that time span remains a mystery, he said. With more than 3,500 Martian days, or sols, under its belt, Opportunity has long outlived its original 90-sol mission. Though the rover was designed to cover only about 1 kilometer of Martian turf, it has traveled 38.7 km so far, or slightly more than 24 miles. It’s no wonder the vehicle is showing its years. Reflecting on the rover’s 10-year anniversary on Mars, Callas observed that Opportunity and Spirit (which sent its last message to Earth in 2010) changed the way people view their place in the solar system. “In addition to being earthlings, because of these rovers, we have become Martians too -- dual citizens, if you will,” Callas said. But age is just a number. Opportunity continues to find new ways to look at the Red Planet. The trek to the rim of Endeavour crater was enough to encounter rocks with completely different chemistry and mineralogy, Squyres said. “We really felt we had a brand-new mission,” he said. “It was like a completely new landing site.”

2024-03-13T01:27:04.277712

https://example.com/article/8959

This work was funded by a Wellcome Trust Strategic Award (grant number: 098330/Z/12/Z) conferred upon The London Down Syndrome (LonDownS) Consortium, and further supported by the Baily Thomas Charitable Fund. NF is funded by EPSRC (EP/M006093/1). DCA\'s work on this topic is supported by EPSRC grants EP/J020990/01 and EP/M020533/1 and the *European Union\'s Horizon 2020 research and innovation programme* under grant agreement No 666992 (EuroPOND: <http://www.europond.eu>). PAW received funding from the CHDI Foundation, a not‐for‐profit organization dedicated to finding treatments for Huntington\'s disease, under grant A‐9856. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Members of the LonDownS Consortium are listed in the Acknowledgments. This article is published with the permission of the Controller of HMSO and the Queen\'s Printer for Scotland Introduction {#acn3571-sec-0005} ============ Down syndrome (DS) is due to full or partial trisomy, translocation, or mosaicism of chromosome 21, and is associated with intellectual disability (ID).[1](#acn3571-bib-0001){ref-type="ref"} DS is also a genetic cause of Alzheimer\'s disease (AD), largely due to triplication of the amyloid precursor protein (*APP*) gene at 21q21.3.[2](#acn3571-bib-0002){ref-type="ref"}, [3](#acn3571-bib-0003){ref-type="ref"}, [4](#acn3571-bib-0004){ref-type="ref"} AD neuropathology is universally present in adults with DS from their fourth decade,[5](#acn3571-bib-0005){ref-type="ref"}, [6](#acn3571-bib-0006){ref-type="ref"} driving an elevated risk for dementia due to AD that is estimated to reach 80% by age 65,[7](#acn3571-bib-0007){ref-type="ref"} though the age of clinical dementia onset shows large variability.[8](#acn3571-bib-0008){ref-type="ref"} The age of onset for dementia in DS is similar to that in familial AD due to mutations in the known AD causing genes ‐ *APP*, presenilin 1 (*PSEN1*) and presenilin 2 (*PSEN2*),[9](#acn3571-bib-0009){ref-type="ref"} with mean age of diagnosis around 55, and an interquartile range of approximately 50--59 years of age.[8](#acn3571-bib-0008){ref-type="ref"} However, unlike familial AD, the sequence and course of dementia in DS is less well‐described, despite this population currently accounting for the majority of genetic AD cases. In individuals with DS, the development of dementia needs to be understood in the context of a complex cognitive phenotype that not only includes general ID, but also specific impairments in executive function, memory, language, and motor domains.[10](#acn3571-bib-0010){ref-type="ref"}, [11](#acn3571-bib-0011){ref-type="ref"} Such pre‐existing impairments in those with DS need to be distinguished from subsequent decline, and in combination with varying baseline abilities and limitations in speech abilities can make the interpretation of cognitive test data, and thus clinical diagnosis, difficult.[12](#acn3571-bib-0012){ref-type="ref"}, [13](#acn3571-bib-0013){ref-type="ref"} The evaluation of longitudinal change suggestive of AD in DS, within and across different cognitive domains, poses significant challenges. In addition to the aforementioned difficulties of assessing decline in the presence of varying degrees of premorbid ID, it is not trivial to understand the long‐term longitudinal progression of a disease when the majority of studies sample populations at different stages of disease progression, by taking cross‐sectional or short‐term longitudinal measurements.[14](#acn3571-bib-0014){ref-type="ref"} Data‐driven methods have become a valuable tool for studying long‐term disease progression due to their ability to estimate long‐term trends from cross‐sectional and short‐term longitudinal snapshots of cohorts, and can be adjusted for variability in baseline ability. The event‐based model (EBM) is one such method capable of estimating orderings of multimodal measurements and staging participants.[15](#acn3571-bib-0015){ref-type="ref"} The EBM has been applied previously to neuroimaging, cerebrospinal fluid (CSF), and cognitive markers in sporadic AD,[16](#acn3571-bib-0016){ref-type="ref"} and more recently was reformulated to model more complex cognitive datasets in young onset AD and posterior cortical atrophy.[17](#acn3571-bib-0017){ref-type="ref"} The aim of this work was to characterize the cognitive deterioration associated with the development of AD in DS. We applied the data‐driven EBM to markers of cognitive and informant‐rated ability of individuals with DS to estimate the order of cognitive decline and assign participants to a disease stage. We further aimed to determine the effect of a clinical diagnosis of dementia and *APOE* genotype on stage, given that *APOE* genotype is strongly associated with age of onset of dementia due to AD, with the *e4* allele driving earlier onset and increased risk and the *e2* allele reducing risk.[18](#acn3571-bib-0018){ref-type="ref"} Methods {#acn3571-sec-0006} ======= Ethics and consent {#acn3571-sec-0007} ------------------ We obtained ethical approval from the National Health Service Research Ethics Committee for the LonDownS consortium\'s longitudinal study of cognitive ability in DS, including approval for collection of DNA samples (13/WA/0194). Individuals with capacity to consent for themselves provided written informed consent, and for those who did not have decision‐making capacity, a consultee was approached to indicate their agreement to the individual\'s participation, in accordance with the UK Mental Capacity Act 2005. Participants {#acn3571-sec-0008} ------------ We recruited individuals with a clinical diagnosis of DS aged 16 years and older living in family homes and residential facilities across England and Wales via a volunteer database, support groups, and local National Health Service (NHS) Trust sites. Participants with any acute physical or mental health condition were excluded from participation until they had recovered. Due to the increased risk of people with DS developing AD neuropathology characterized by amyloid deposition beyond age 35 as demonstrated by neuropathological and amyloid positron emission tomography studies,[2](#acn3571-bib-0002){ref-type="ref"}, [19](#acn3571-bib-0019){ref-type="ref"}, [20](#acn3571-bib-0020){ref-type="ref"} we used age 35 to split participants into two age groups. The young adult (YA) group, aged 16--35, were likely performing at or near to their cognitive peak, while the older adult (OA) group, aged 36 and older, were expected to have AD neuropathology with individuals presenting with varying degree of cognitive decline. We therefore defined the YA group as a predecline "control" group, while the OA group was used as a "pathological" group in the model due to the likelihood that many of the OA group have already undergone cognitive deterioration, whether they have been diagnosed with dementia or not. This approach was chosen because we wished to identify the stages of cognitive decline associated with prodromal AD in DS leading up to clinical dementia diagnosis. In subsequent analyses, we used dementia status to test the validity of the model. The semisupervised mixture modeling technique used ([Event‐based model](#acn3571-sec-0015){ref-type="sec"}) has been previously shown to be capable of discerning splits from heterogeneous inputs, such as the YA and OA groups in this work. Cognitive test battery {#acn3571-sec-0009} ---------------------- We selected tests and outcomes from the LonDownS cognitive battery that showed good psychometric properties across the age groups: General cognitive abilities were assessed using raw scores from the verbal and nonverbal subscales of the Kaufman Brief Intelligence Test 2 (KBIT‐2).[21](#acn3571-bib-0021){ref-type="ref"}Visuospatial associate memory was assessed with the first trial memory score from the CANTAB paired associates learning (PAL) task.[22](#acn3571-bib-0022){ref-type="ref"} This sums the number of pattern positions correctly recalled after their first presentation in all stages attempted.Object memory was assessed using an adapted form of the Fuld object memory test.[23](#acn3571-bib-0023){ref-type="ref"} This task provides measures of immediate and 5‐min delayed memory recall.Orientation abilities were assessed by asking participants questions about when it was (the day, month, and year), and where they were.[24](#acn3571-bib-0024){ref-type="ref"}The intra/extra dimensional set shift (IED) task is a measure of rule learning and set shifting from the CANTAB.[22](#acn3571-bib-0022){ref-type="ref"} Here, we used the total number of stages completed.An adapted version of the Tower of London for individuals with an ID assessed working memory and planning.[11](#acn3571-bib-0011){ref-type="ref"}, [25](#acn3571-bib-0025){ref-type="ref"}To measure semantic verbal fluency participants were asked to name as many animals as possible in 1 min.The mean latency of responses in the simple reaction time (SRT) task from the CANTAB was used as a measure of attention and motor abilities.[22](#acn3571-bib-0022){ref-type="ref"}, [26](#acn3571-bib-0026){ref-type="ref"}The finger‐nose pointing test is a clinical measure of motor coordination.[27](#acn3571-bib-0027){ref-type="ref"}The car and motorbike score from the NEPSY‐II -- visuomotor precision task assesses hand‐eye coordination.[28](#acn3571-bib-0028){ref-type="ref"} Informants (relatives or paid carers) completed standardized questionnaires. These included: The Short Adaptive Behavior Scale (short ABS),[29](#acn3571-bib-0029){ref-type="ref"} adapted from the Adaptive Behavior Scale -- Residential and Community (Part I),[30](#acn3571-bib-0030){ref-type="ref"} records participants' everyday adaptive abilities.The Dementia Questionnaire for People with Learning Disabilities (DLD) measures behaviors associated with cognitive decline in people with ID over the last two months.[31](#acn3571-bib-0031){ref-type="ref"} Cognitive and social domains scores were included.The Observer Memory Questionnaire (OMQ) measures individuals' memory abilities over the last 2 months We developed a revised, shorter version, by selecting the most reliable items appropriate for use in adults with ID.[32](#acn3571-bib-0032){ref-type="ref"} Further information about the LonDownS participants, cognitive assessments, and informant questionnaires can be found in (Startin et al. 2016[11](#acn3571-bib-0011){ref-type="ref"}), with a summary of tests and outcomes used in Table [1](#acn3571-tbl-0001){ref-type="table-wrap"}. ###### Summary of assessments used Test name Primary abilities assessed Description Outcomes and score ranges -------------------------------------------------------------------- --------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------ -------------------------------------------------------- Participant tests Kaufmann brief intelligence test 2 (KBIT‐2) General cognitive abilities Subtests assess participants' verbal abilities (verbal knowledge and riddles) and nonverbal abilities (matrices) Verbal raw score (0--108); Nonverbal raw score (0--46) CANTAB paired associates learning (PAL) Visuospatial associate memory Participants were required to remember locations of an increasing number of patterns, hidden behind boxes on a computer screen First trial memory score (0--26) Object memory test Recall memory Participants were required to name and remember a series of objects, then recall them in two immediate trials and one 5 min delayed trial Immediate recall (0--14); Delayed recall (0--7) CAMCOG orientation Orientation Assesses participants' knowledge of when it is and where they are Total score (0--12) CANTAB intra/extra dimensional set shift (IED) Rule learning and set shifting Participants were required to learn rules about which was the 'correct' of two presented patterns on a computer screen, with a rule change after six consecutive correct trials Number of stages completed (0--9) Tower of London Working memory and planning Participants were required to move beads on a board to match presented configurations. Total score (0--10) Verbal fluency Semantic verbal fluency Participants were asked to name as many animals as possible in 1 min Number of unique animals (0‐N/A) CANTAB simple reaction time (SRT) Attention/motor abilities Participants were required to press a button as soon as a white square appeared on a computer screen Mean latency (N/A) Finger‐nose pointing Motor coordination Participants alternatively touch their nose and a red circle 45 cm away for 20 sec Total number of times the circle is touched (0‐N/A) NEPSY‐II visuomotor precision Hand‐eye coordination Participants were timed as they traced around train, car, and motorbike tracks, with times and number of errors for each track used to determine overall scores Car and motorbike score (0--52) Informant ratings Short adaptive behavior Scale (Short ABS) Adaptive abilities Informants answer questions about everyday adaptive abilities Total score (0--113) Dementia questionnaire for people with learning disabilities (DLD) Memory and orientation/adaptive abilities Informants answer questions about behaviors associated with cognitive decline over the last 2 months Cognitive abilities (0--44); Social abilities (0--60) Revised observer memory questionnaire (OMQ) Memory Informants answer questions about individuals' memory abilities over the last 2 months Total score (18--90) John Wiley & Sons, Ltd Imputation {#acn3571-sec-0010} ---------- Floor effects and difficulty to engage in cognitive tasks are a significant issue in studies of cognitive decline in individuals with DS, and excluding those who score at floor or who do not engage could significantly bias analyses. We therefore imputed scores as follows: individuals who attempted tasks but were clearly unable to understand task instructions were allocated a score of zero for outcomes aside from SRT mean latency, where the poorest score recorded was given. Missing items from the DLD and OMQ were imputed for up to 15% of items within each domain with the nearest integer to the mean value of completed scores. ID severity score {#acn3571-sec-0011} ----------------- Premorbid ID level was defined according to the ICD10 diagnostic system, and classified into three levels based on caregiver\'s reports of the individual\'s best ever level of functioning ‐ mild, moderate, and severe ID, corresponding to the general functional abilities associated with IQ levels of 50--69, 35--49, and \<35, respectively, as described elsewhere.[33](#acn3571-bib-0033){ref-type="ref"} Dementia diagnoses {#acn3571-sec-0012} ------------------ Dementia diagnoses were used to test the validity of the staging model, and were defined as the presence of an existing, independent clinical diagnosis from each individual\'s clinician after comprehensive clinical assessment. Clinical diagnosis has previously been shown to be reliable.[34](#acn3571-bib-0034){ref-type="ref"} None of the tests used in the EBM were used to inform diagnoses. Genetic analysis {#acn3571-sec-0013} ---------------- Participants' DS status was confirmed genetically using saliva or blood samples where possible; following DNA extraction, genome‐wide single nucleotide polymorphism (SNP) genotyping was performed using an Illumina OmniExpressExome array (San Diego, CA) at UCL Genomics, then assembled and visually inspected in GenomeStudio to confirm the presence of an additional copy of chromosome 21, mosaicism, or translocation. *APOE* genotype was determined using a Thermo Fisher Scientific Taqman assay for SNPs rs7412 and rs429358 (Waltham, MA). Event‐based model {#acn3571-sec-0014} ----------------- Scores from the cognitive tests and informant questionnaires, controlled for ID level, were used as input in the EBM, with scores termed as 'biomarkers' for the remainder of this paper, for brevity and to be consistent with previous descriptions of the model.[15](#acn3571-bib-0015){ref-type="ref"}, [16](#acn3571-bib-0016){ref-type="ref"} Unimodal, two‐component, nonparametric mixture models were fit for each of the biomarkers, these models were then used to assign probabilities $P(x|E_{i})$ and $P(x|\neg E_{i})$ of a biomarker measurement, *x*, being abnormal (event *E* ~*i*~ has occurred) or normal (*E* ~*i*~ has not occurred) that is the measurement indicating dementia or not respectively.[17](#acn3571-bib-0017){ref-type="ref"} The OA and YA groups were used to define the initial components in each mixture model, by defining each group as a component and then fitting kernel density estimations to each group separately. The fitting procedure then uses these initial components to estimate two components corresponding to a dementia and nondementia subpopulation. This is possible as mixture modeling is a semisupervised method capable of learning underlying patterns in the data that correspond to dementia or not, despite being only provided with the YA and OA labels. The EBM was then used to estimate the maximum likelihood ordering of events. In this work the ordering of events corresponds to the order of decline on cognitive tests and informant questionnaires, which transition outside of a premorbid range due to cognitive decline associated with AD progression. The EBM was used as previously described,[35](#acn3571-bib-0035){ref-type="ref"} briefly an event sequence S, was optimized using Markov chain Monte Carlo (MCMC) sampling to maximize the probability of the full set of data, *X* (all biomarkers from all individuals), given by$$P\left( {X|S} \right) = \prod\limits_{i = 1}^{J}\left\lbrack {\sum\limits_{k = 0}^{I}\left( {\prod\limits_{i = 1}^{k}P\left( {x_{\mathit{ij}}|E_{i}} \right)\prod\limits_{i = k + 1}^{I}P\left( {x_{\mathit{ij}}{|\neg}E_{i}} \right)} \right)} \right\rbrack$$where $i \in I$ is the biomarker index and $j \in J$ is the participant number. The fitting procedure identifies the maximum likelihood sequence $\hat{S}$, from which disease stages were estimated for individuals given their test scores. Similar to previous descriptions of the EBM (e.g.[16](#acn3571-bib-0016){ref-type="ref"}), we used the stage, $k_{j}$, which has the highest probability given the data and our sequence, i.e.$${\hat{k}}_{j} = \text{argma}x_{k}P\left( {X_{i}|\hat{S},k} \right) = \text{argma}x_{k}\prod\limits_{i = 1}^{k}P\left( {x_{\mathit{ij}}|E_{i}} \right)\prod\limits_{i = k + 1}^{I}P\left( {x_{\mathit{ij}}{|\neg}E_{i}} \right)$$ Disease stages for adults in the OA and YA groups were then compared, as were stages of adults in the OA group with and without a clinical diagnosis of dementia, and stages for individuals with different *APOE* genotypes for the YA and OA groups separately. The APOE4 group was defined as those possessing a copy of the *APOE* e4 allele (*APOE* 3:4 and 4:4), while the APOE2 group included individuals possessing a copy of the *APOE* e2 allele (*APOE* 2:2 and 2:3), and the APOE3 group consisted of those possessing two copies of the *APOE* e3 allele (*APOE* 3:3). Individuals with *APOE* 2:4 genotype were omitted from this analysis. All group comparisons used Mann--Whitney *U* tests. Results {#acn3571-sec-0015} ======= This analysis included 283 participants, with details of participants included in the study summarized in Table [2](#acn3571-tbl-0002){ref-type="table-wrap"}. ###### Demographic data and mean (SD) neuropsychological scores for younger adult and older adult groups Younger adults Older adults --------------------------- --------------------------------- ----------------------------------- -------------------------------- Participants *n* 119 164 DS status confirmed *n* = 115 *n* = 156 110 trisomy 150 trisomy 1 translocation 1 translocation 3 mosaic 5 mosaic 1 partial trisomy Age 25.24 (5.58) 49.58 (7.47)\*\*\* Gender 57 M; 62 F 87 M; 77 F LD level 45 mild; 63 moderate; 11 severe 69 mild; 67 moderate; 28 severe Clinical dementia status 119 no dementia 121 no dementia; 43 dementia *APOE* genotype *n* = 111 *n* = 151 *n* = 19 *APOE* 2:2 or 2:3 *n* = 22 *APOE* 2:2 or 2:3 *n* = 60 *APOE* 3:3 *n* = 90 *APOE* 3:3 *n* = 31 *APOE* 3:4 or 4:4 *n* = 35 *APOE* 3:4 or 4:4 *n* = 1 *APOE* 2:4 *n* = 4 *APOE* 2:4 Tests KBIT‐2 raw verbal *n* = 119; 34.95 (16.99) *n* = 164; 23.02 (18.77)\*\*\* KBIT‐2 raw non‐verbal *n* = 119; 15.00 (6.94) *n* = 154; 9.78 (7.43)\*\*\* PAL first trial memory *n* = 107; 10.19 (5.67) *n* = 144; 4.53 (5.61)\*\*\* IED stages complete *n* = 108; 6.52 (2.59) *n* = 144; 3.41 (3.06)\*\*\* SRT mean latency *n* = 104; 695.72 (455.97) *n* = 137; 1423.08 (793.61)\*\*\* Delayed object memory *n* = 109; 5.78 (1.52) *n* = 151; 3.60 (2.66)\*\*\* Immediate object memory *n* = 109; 10.26 (3.00) *n* = 151; 6.41 (4.75)\*\*\* NEPSY car motorbike score *n* = 116; 17.12 (9.56) *n* = 151; 8.05 (8.91)\*\*\* Tower of London *n* = 113; 7.24 (3.12) *n* = 155; 4.41 (3.97)\*\*\* Finger nose *n* = 114; 11.02 (5.25) *n* = 155; 6.09 (5.48)\*\*\* Verbal fluency *n* = 115; 10.81 (5.91) *n* = 157; 6.10 (5.92)\*\*\* Orientation *n* = 113; 9.55 (3.56) *n* = 155; 6.52 (4.71)\*\*\* DLD cognitive *n* = 111; 7.57 (8.35) *n* = 140; 15.68 (12.75)\*\*\* DLD social *n* = 114; 9.31 (6.87) *n* = 143; 14.66 (10.52)\*\*\* Short ABS total *n* = 114; 79.60 (19.46) *n* = 144; 64.79 (27.00)\*\*\* OMQ revised *n* = 116; 43.42 (12.31) *n* = 141; 56.38 (17.16)\*\*\* Significant differences between groups have been highlighted, *p *\<* *0.005 (\*\*\*). John Wiley & Sons, Ltd Event sequences {#acn3571-sec-0016} --------------- To account for the severity of cognitive deficits not caused by dementia development but instead due to the intellectual impairments associated with DS, ID level was used to estimate residuals in the YA group for each biomarker using linear regression coefficients, then these coefficients were used to calculate residuals for all individuals' biomarker measurements. An EBM was fit using the YA and OA groups as control and disease populations, respectively, and a maximum likelihood event sequence was obtained together with sampling uncertainty (Fig. [1](#acn3571-fig-0001){ref-type="fig"}A). As this method is Bayesian we did not directly estimate significance, instead a stricter estimate of uncertainty in the maximum likelihood event sequence was estimated by bootstrap resampling of the data and refitting the model 100 times (Fig. [1](#acn3571-fig-0001){ref-type="fig"}B). {#acn3571-fig-0001} The resulting event sequence implicates decline in visuospatial associate memory (measured using the CANTAB PAL first trial memory score), hand‐eye coordination (using the NEPSY‐II car/motorbike score), and semantic verbal fluency as early events associated with the likely development of significant AD neuropathology in older adults with DS. Although these tasks cover different cognitive domains, they all rely on sustained attention to perform well, indicating a common underlying ability. Tests of object memory and planning/rule learning such as the Tower of London defined midsequence events, while late events were defined by informant‐rated scales of everyday function and cognitive ability (DLD, short ABS, and revised OMQ; Fig. [1](#acn3571-fig-0001){ref-type="fig"}A). Bootstrapping shows a high degree of certainty in the event sequence (Fig. [1](#acn3571-fig-0001){ref-type="fig"}B). Staging {#acn3571-sec-0017} ------- Using the maximum‐likelihood event sequence a disease stage was assigned to each participant. The distribution of stages in the YA and OA groups (Fig. [2](#acn3571-fig-0002){ref-type="fig"}) show that the YA group is significantly more likely to be at the earlier stages of the disease (*U* = 4489.5, *p *\<* *0.001). The OA group, which was assumed to all have some degree of AD neuropathology, shows a spread along the event stages. {#acn3571-fig-0002} As the disease population used in this model (i.e. the OA group) consists of individuals who do not have a clinical diagnosis of dementia, we further analysed the stages of the OA group comparing those with and without clinical dementia diagnoses (Fig. [3](#acn3571-fig-0003){ref-type="fig"}). From this we see that individuals with a clinical diagnosis of dementia are significantly more likely to be staged later according the EBM (*U* = 743, *p *\<* *0.001). {#acn3571-fig-0003} Splitting individuals based on *APOE* genotype, we saw no relationship with disease stage in the YA group (Fig. [4](#acn3571-fig-0004){ref-type="fig"}A), however, in the OA group we observed that individuals in the APOE4 group were significantly more likely to be staged later according to the EBM compared to both the APOE2 (*U* = 205.5, *p *\<* *0.002) and APOE3 (*U* = 950, *p *\<* *0.001) groups (Fig. [4](#acn3571-fig-0004){ref-type="fig"}B). {#acn3571-fig-0004} Discussion {#acn3571-sec-0018} ========== Using data from nearly 300 adults with DS, we have applied an EBM to characterize the sequence of AD‐related cognitive deterioration in DS. Our estimated event ordering represents the first AD progression model of this type in DS, a population at exceptionally high genetic risk of developing dementia and representing the majority of genetic AD cases. Results suggest decline in visuospatial paired associate memory, hand‐eye coordination, and semantic verbal fluency may be relatively sensitive events during the prodromal stage of AD in DS. Changes in planning abilities and rule learning/shifting may occur slightly later, while changes in informant‐rated behaviors and abilities appeared latest in the model. These results suggest that direct cognitive tests may be more sensitive to early changes than informant‐rated questionnaires. This highlights the need for baseline cognitive assessments in this population to enable early intervention, as subtle changes in cognitive tests may be seen before carers identify decline. The staging distribution of individuals with clinical dementia diagnoses provides validity to the model, and suggests that clinical diagnoses are generally made at a relatively late stage of AD progression in DS. As additional validation of the model, we showed that older individuals with *APOE* 3:4 or 4:4 genotype were more likely to be allocated to later disease stages than those not possessing an *APOE* e4 allele. As with sporadic AD, in DS there is a time lag of up to several decades between the development of AD neuropathology and meeting the threshold for clinical dementia diagnosis.[2](#acn3571-bib-0002){ref-type="ref"}, [36](#acn3571-bib-0036){ref-type="ref"}, [37](#acn3571-bib-0037){ref-type="ref"} Memory decline, particularly for episodic memory, is viewed as the classic presenting symptom of AD, which gradually progresses to involve other cognitive domains.[38](#acn3571-bib-0038){ref-type="ref"} However, studies of familial AD mutation carriers have found that some individuals show decline in measures of sustained attention, executive function, language, or behavior several years prior to dementia diagnosis,[39](#acn3571-bib-0039){ref-type="ref"}, [40](#acn3571-bib-0040){ref-type="ref"}, [41](#acn3571-bib-0041){ref-type="ref"} suggesting the sequence of changes we have shown in our population with DS is comparable to that seen in other genetic AD populations. Previous EBM models have shown that in sporadic AD, changes in cognitive abilities, including memory and attention, follow changes in CSF biomarkers, but occur before brain volumetric changes.[16](#acn3571-bib-0016){ref-type="ref"}, [42](#acn3571-bib-0042){ref-type="ref"} The cognitive tests used in these models have tended to combine several cognitive processes. Here, by including tests for more specific cognitive processes as separate biomarkers, we can look more closely at the sequence of decline in populations where obtaining CSF biomarkers, for example, may be challenging. It has been suggested that executive function decline and behavioral and personality changes may precede memory impairment in dementia development in DS,[43](#acn3571-bib-0043){ref-type="ref"}, [44](#acn3571-bib-0044){ref-type="ref"} with some studies reporting that individuals with DS may present with a frontal‐like dementia syndrome in the earliest stages.[43](#acn3571-bib-0043){ref-type="ref"}, [45](#acn3571-bib-0045){ref-type="ref"} A recent systematic review of longitudinal DS studies drew similar conclusions,[46](#acn3571-bib-0046){ref-type="ref"} however, large variability in the follow‐up period and cognitive tasks used prevented a meta‐analysis, and several of the studies included found, like us, that memory and spatial orientation decline seemed to happen first.[47](#acn3571-bib-0047){ref-type="ref"}, [48](#acn3571-bib-0048){ref-type="ref"}, [49](#acn3571-bib-0049){ref-type="ref"} Test sensitivity is a key challenge when assessing baseline cognition and subsequent decline in DS, and may explain these apparently conflicting findings. Some of the studies in the previously mentioned review relied on informant report, which our model suggests may be less sensitive to early change than direct cognitive assessment. Furthermore, Lautarescu and colleagues highlighted that those with a standardized IQ \< 40 had very low scores on the memory tasks used, regardless of their dementia status. The CANTAB PAL and object memory tasks used in our battery (but none of the reviewed studies) allowed us to assess visuospatial memory and immediate and delayed recall of everyday items in the majority of our sample, with fewer than 1% of our younger adults aged 16--35 (including many with IQ \< 40) at floor on delayed object memory trials,[11](#acn3571-bib-0011){ref-type="ref"} suggesting that these specific tests are suitable for those with DS and can identify decline in this population. However, for the object memory task, 40% of our younger adults were scoring at ceiling for the delayed object memory trial, suggesting this test may be insufficiently sensitive for measuring ability changes in those with comparatively strong premorbid delayed object memory. Future studies should perhaps increase the number of objects used to improve sensitivity. The sequence of events revealed by our model has important clinical implications, and suggests that tests of visuospatial associate memory, hand‐eye coordination, and verbal fluency may be particularly useful to track early, subtle cognitive change in middle‐aged individuals with DS in the preclinical and prodromal stages of AD. These tests may all have decline in sustained attention in common, indicating this may be another important aspect of cognition to track changes. The model also suggests that informant‐reported measures may be more useful somewhat later in the course of progression in the lead‐up to dementia diagnosis, and to monitor progression after diagnosis. AD staging based on EBM could help clinicians track decline during the early stages of cognitive decline in DS, and enable earlier diagnosis that might be beneficial by allowing for timely care‐planning and support. It could also be of use to distinguish a typical sequence of events associated with AD development from the reversible decline that might be due to other, treatable, comorbidities, such as depression or hypothyroidism. Equally promising is the potential use of this model to enable AD staging in clinical trials to select appropriate participants with DS for particular trials, for example those designed to prevent or delay onset of dementia in the prodromal stages. It might also be possible to use such models in the analysis of clinical trial data, by comparing different treatments or placebo controls in terms of progression along the stages of the model. However, we acknowledge that data from further longitudinal studies may be required to confirm and refine the staging model for these applications. Due to the flexibility of the model we can confirm our staging model by using follow‐up data in the model independently, and also by staging patient\'s follow‐up scores and checking the monotonicity of patients EBM stage trajectories. This analysis is based on one of the largest and most detailed studies of cognitive decline in DS to date. Participants completed a battery of cognitive tests, which were specifically designed to cover domains commonly affected by DS, including aspects of memory, motor coordination, and executive functions. The tests were adapted to be suitable for use in individuals with DS and selected to minimize reliance on verbal ability, a known area of weakness in individuals with DS. Tests were validated in older adults with DS[50](#acn3571-bib-0050){ref-type="ref"} before being applied in a large sample including both younger and older adults with DS which allowed for selection of tests with acceptable floor and ceiling effects.[11](#acn3571-bib-0011){ref-type="ref"} However, we acknowledge the lack of tasks specifically focusing on verbal memory, which is often one of the earliest domains affected in AD. By using an innovative approach and designating older adults with DS as likely being along a decline trajectory regardless of dementia status, it allowed us to provide a more complete picture of the sequence of events associated with the progression of AD in DS than has been possible to date. Furthermore, the EBM methodology allows for inclusion of individuals who had floored on some tests, which is usually a major limitation to cognitive testing in older individuals with DS.[10](#acn3571-bib-0010){ref-type="ref"} In conclusion, we have used a data driven approach to overcome some of the common issues in analysis of cognitive data in individuals with DS, and our results reveal that the sequence of events in the progression of AD in DS is comparable to events during the development of AD in other populations, including those with autosomal dominant AD. Specifically, the event sequence suggests that early decline in memory and sustained attention is followed by decline in planning and rule learning/shifting, and occurs before behavioral symptoms as reported by informants. These results help to clarify uncertainties about the sequence of events and staging of AD in DS. Future work including longitudinal data in such models will improve our understanding of decline due to AD in DS further, and will help to improve dementia diagnosis, as well as to inform selection of cognitive outcome measures in future clinical trials to prevent or delay the development of dementia during the prodromal period. Conflicts of Interest {#acn3571-sec-0020} ===================== The authors declare no conflicts of interest. Author Contributions {#acn3571-sec-0021} ==================== AS conceived the adult cohort study in conjunction with LonDownS principal investigators. CMS, RH, and SH contributed significantly to recruitment and data collection. KYM and JH contributed to genetic analysis and interpretation of the genetic data. NF, PW, DCA, and AS designed the data analysis. NF analysed the data. NF, CMS, RH, SH, and AS wrote the paper. All authors contributed to the reviewing and editing of the paper. The authors acknowledge all the participants in this study for their time. This research was supported by the National Institute for Health Research networks (mental health, dementias and neurology) and participating NHS trusts. We also thank our NHS network of sites that helped to identify participants. The LonDownS Consortium principal investigators are Andre Strydom (chief investigator), Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King\'s College London, London, UK, and Division of Psychiatry, University College London, London, UK; Elizabeth Fisher, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; Dean Nizetic, Blizard Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK, and Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore; John Hardy, Reta Lila Weston Institute, Institute of Neurology, University College London, London, UK, and UK Dementia Research Institute at UCL, London, UK; Victor Tybulewicz, Francis Crick Institute, London, UK, and Department of Medicine, Imperial College London, London, UK; and Annette Karmiloff‐Smith, Birkbeck University of London, London, UK (deceased). Students who all helped with data collection entry, or checking during a placement with LonDownS were: Nidhi Aggarwal, Amy Davies, Lucy Fodor‐Wynne, Bryony Lowe, and Erin Rodger. Tamara Al‐Janabi managed the LonDownS project as a whole.

2023-12-22T01:27:04.277712

https://example.com/article/1389

The fate of Congress-led coalition government in Karnataka now lies with Governor T N Chaturvedi, after Chief Minister Dharam Singh failed on Friday to secure a confidence vote on the floor of the assembly, as earlier directed by him. Amidst chaotic scenes in the House, the Congress wanted another opportunity for trial of strength. Uproar marred the proceedings in the assembly, after which the House was adjournedsine die by Speaker Krishna before the chief minister could obtain a vote of trust. Late on Friday night, Singh met the Governor and requested him to fix an early date to enable him to seek the trust vote. Singh told reporters after the meeting that the date could be either Saturday or Sunday. The Governor, Singh said, assured them he would examine the issue and take a decision on Saturday. Later, Bharatiya Janata Party and rebel Janata Dal (Secular) MLAs, led by H D Kumaraswamy, also met Chaturvedi and sought dismissal of the Dharam Singh government, on the ground that it had failed to prove its majority on the floor of the House. On a day of dramatic developments, trouble compounded for the Dharam Singh government when Congress failed to persuade a majority of JD(S) MLAs owing loyalty to Kumaraswamy, to back the government. Gowda resigned as JD(S) president, accepting moral responsibility for the failure. The proceedings in the assembly ended abruptly when Singh refused to move the trust motion because of uproar, ironically caused by his partymen, who were in the well of the House, yelling against the Speaker's recognition of Kumaraswamy as JD(S) legislature party leader. As the chief minister did not heed the Speaker's repeated pleas to move the confidence motion, Krishna adjourned the house indefinitely, telling the members that he would report the matter to the Governor. Singh himself remained defiant, ruling out his resignation, saying, "When I have not taken the vote of confidence, why should I resign." Singh said he told the Governor that the Speaker did not give him a chance to prove his majority and he adjourned the House 'in haste'. The Speaker told reporters later that the chief minister failed to seek the trust vote, despite adjourning the House thrice and giving him the opportunity, making repeated pleas to move the confidence motion. "The chief minister did not fulfil his constitutional obligation," Krishna said, noting that the session was called in accordance with the decision of the Governor to help him seek a vote of confidence. "I have no option other than reporting the matter to the Governor. I will discharge my constitutional duty," said the Speaker. Krishna earlier recognised Kumaraswamy as JDSLP leader, in place of the incumbent Deputy Chief Minister M P Prakash, inviting a storm of protests from Congress. Asked about the fate of the government, Krishna said it would be decided by the Governor. With JD(S) rebels refusing to budge from their position to team with BJP and Gowda having failed to persuade his son to change, the legislative arthimetic was loaded in favour of the BJP-JD(S) combination. In the 224-member assembly, BJP has 79 members and JD(S) rebels 44, including five independents, besides five of the saffron party's ally JD(U), which took their numerical strength to 128, well above the figure of 113 required to command majority. In another dramatic twist, Gowda also resigned as JD(S) national president after his efforts to dissuade his son from embracing BJP came to nought, pleading his inability to maintain unity of the party in his home state.

2024-06-06T01:27:04.277712

https://example.com/article/1179

Entroncamento – Badajoz passenger service reinstated 2017-08-31T07:55:59+01:00 PORTUGAL: National operator CP reinstated a daily return passenger service on the 141 km Eastern Line between Entroncamento and the Spanish city of Badajoz on August 29, using Allan diesel railcars built in the 1950s and refurbished by EMEF Contumil in the early 2000s. Passenger services on the route had been withdrawn in January 2012 following the publication in 2011 of the then-government’s Sustainable Mobility: Horizon 2011-2015 transport plan which recommended replacement by buses. While the line remained open for freight, this left the Portalegre district without any regional passenger rail services until September 2015, when a Entroncamento – Portalegre service began operating on Fridays and Sundays under an agreement between CP, infrastructure manager Infraestruturas de Portugal, the municipalities of Alter do Chão, Ponte de Sor and Portalegre and the Alentejo Regional Co-ordination & Development Commission. The service to Badajoz has now been reintroduced after parliament backed a proposal from one of the parties that supports the current government and seeks to reverse rail closures. On March 31 Infraestruturas de Portugal called tenders for an €18·5m upgrade of the 11 km between Elvas and the Spanish border as part of the first phase of the proposed South International Corridor, which would provide a direct connection between the port of Sines and the Spanish network at Caia. Topics Related articles PORTUGAL: Minister of Planning & Infrastructure Pedro Marques attended a ceremony at Barcelos station on June 24 to officially launch the €83∙2m project to electrify the 90∙8 km route between Nine, north of Porto, and Valença on the Spanish border. PORTUGAL: Infraestruturas de Portugal announced on October 19 that it had signed a contract worth €16m with Mota-Engil, covering electrification of the 44 km Nine – Viana do Castelo section of the route between Porto and Valença on the Spanish border. PORTUGAL: Minister of Planning & Infrastructure Pedro Marques has announced the start of work to rehabilitate the Guarda – Covilhã section of the Beira Baixa route by mid-2019. To be completed within a budget of €88m, rehabilitation of the railway, which has been out of use since 2009, would provide ...

2023-09-14T01:27:04.277712

https://example.com/article/8522

Landing in theaters today is the excellent 10 Cloverfield Lane. Produced by J.J. Abrams and directed by Dan Trachtenberg, the suspense-driven movie acts as a ‘blood relative’ to the original Cloverfield movie though no one is going as far as calling it a sequel. Having had a chance to watch the flick last night, I can tell you that you’re in for a treat and that you will want to see it before being spoiled on its ending. Dan Trachtenberg talking about how they were able to make the film feel so personable: …I did feel like that Cloverfield – its first-person perspective made that movie so much more of an experience. I really wanted this movie to also feel that subjective and feel less like something being watched and more like an experience. So, I actually turned to video games for inspiration. Not surprisingly, the games Dan and company were inspired by and borrowed from included Uncharted and The Last of Us – two games known for their cinematic scope and feel. More after the jump. I love the design of a lot of these 3rd person action games, if you think of the Uncharteds or Last of Us. Those games feel as subjective as the first person shooters do, so I think, stealing from some of their design elements, we were able to make this feel – even though it was very classically told, in a more traditional filmmaking style – you still feel like you are vicariously experiencing everything that the protagonist is experiencing and you really feel in her shoes. Discuss: Will you be watching 10 Cloverfield Lane and if you’ve already seen it, what did you think? [Via IGN]

2023-09-07T01:27:04.277712

https://example.com/article/9003

ISS crew take to escape capsules in space junk alert - J3L2404 http://www.bbc.co.uk/news/science-environment-17497766 ====== Sephr Planetes (hard sci-fi manga and anime) is becoming closer to reality every day. We need to address space debris now before we end up like that. ~~~ AgentConundrum In case anyone else was unfamiliar with this, I looked it up[1]: > _Planetes [...] is a Japanese hard science fiction manga by Makoto Yukimura. > [...] The story revolves around a team of space debris collectors based in > the debris ship Toy Box in the year 2075._ [1] <https://en.wikipedia.org/wiki/Planetes> ------ tommi Wikipedia has very good article on space debris <http://en.wikipedia.org/wiki/Space_debris> ------ jedberg The second part of the article was much more interesting, especially the graph at the end. ------ xbryanx :TODO: @CN - Stop firing missiles at satellites in space.

2024-02-05T01:27:04.277712

https://example.com/article/4285

Q: Связать Combobox с колонкой dataGrid wpf Приветствую, народ! Мой вопрос заключается в следующем: Есть форма wpf selectedObjectsDataGrid.ItemsSource = attributesManager.ObjectsInGrid; Ее сорс - это лист объектов ObjectInGrid public class ObjectInGrid { private ObjType? type; public Guid Object { get; set; } public ObjType? Type { get { return type; } set { type = value; } } public ObjectInGrid(Guid obj) { Object = obj; } public enum ObjType { None = 0, Door = 1, Window = 2 } } В комбобоксе есть три варианта (как в enum ObjType). Объекты поступают в датагрид так: пользователь выделяет один или несколько объектов в документе. по нажатию, грубо говоря, создается объект public void AddObjectToGrid(Guid id) { ObjectInGrid o = new ObjectInGrid(id); ObjectsInGrid.Add(o); } Property Type, как и колонка Type пока пустые. когда пользователь добавил все объекты, он выделяет в гриде один или несколько объектов и в комбобоксе выбирает тип. На событие SelectionChanged комбобокс находит по id элемент в листе-сорсе и заполняет проперти Type. Я только начала работать с WPF, но предполагаю, что там есть возможность как-то "связать" колонку типа и комбобокс нормальным способом, а не как у меня вручную. В моем подходе мне не нравится: Событие SelectionChanged срабатывает, когда меняется выделенный айтем, но если я выбираю другой объект и мне нужно для него поставить такой же тип как и в прошлом - оно не генерится. Хотелось бы сделать все на более высоком уровне. Гуглила, искала, но ничего конкретного для выполнения этой задачи не нашла. A: Окей, судя по всему, вам нужно вот что: <ItemsControl ItemsSource="{Binding ObjectsInGrid}" SelectedValue="{Binding SelectedObjectInGrid}" ...> <!-- ... --> </ItemsControl> <Window.Resources> <ObjectDataProvider x:Key="ObjTypeEnumValues" MethodName="GetValues" ObjectType="{x:Type sys:Enum}"> <ObjectDataProvider.MethodParameters> <x:Type Type="src:ObjType" /> </ObjectDataProvider.MethodParameters> </ObjectDataProvider> </Window.Resources> <Combobox ItemsSource="{Binding Source={StaticResource ObjTypeEnumValues}}" SelectedValue="{Binding SelectedObjectInGrid}" DisplayMemberPath="Type"/> Вроде бы code-behind не нужен вовсе. Но вам нужно установить правильный DataContext. Да, ещё одна проблема вашего кода: ваша ViewModel (то есть, класс, к которому будет Binding), а именно, класс ObjectInGrid, не реализует интерфейс INotifyPropertyChanged. Это важно, обязательно имплементируйте его. Иначе работать не будет.

2024-03-01T01:27:04.277712

https://example.com/article/3314

The Lt. Governor of California, Gavin Newsom, has released a statement offering lukewarm condemnation of the riots that prevented MILO’s final event of the “Dangerous Faggot Tour,” whilst smearing him as a “white supremacist.” Newsom, who has launched a campaign for Governor of California in 2018, said in a statement that people experienced “both extremes at UC Berkeley’s campus last night, from the racism and misogyny of fly-by-night provocateur and white supremacist Milo Yiannopoulos, to the excessive response of a few protestors.” The event was cancelled after left-wing rioters, who the university claim were not students, smashed ATMs and bank windows, looted a Starbucks, beat Trump supporters, pepper sprayed innocent individuals, set fires in the street, and sprayed the words “Kill Trump” on storefronts. He then went on to attack President Donald Trump, who yesterday condemned the protests whilst threatening to cut university’s $350 million of federal funding, over half its budget. If U.C. Berkeley does not allow free speech and practices violence on innocent people with a different point of view – NO FEDERAL FUNDS? — Donald J. Trump (@realDonaldTrump) February 2, 2017 “President Trump’s asinine threat to pull funding from Cal showed zero awareness of the real-world implications of a President’s words and actions. Stripping federal funds from UC would only create more innocent victims and more Trump carnage,” he said. “President Trump is quick to attack American students, immigrants, women, the LGBT community, journalists, and our international allies but he is either too weak or too ignorant to stand up to white supremacists and others who spew hatred. That’s why the President and his extremist acolytes like Yiannopoulos need to hear from the resistance, loudly and repeatedly. We must continue to step in and stand up to resist reckless rhetoric and actions in a peaceful and forceful manner,” he continued. Yesterday, on FOX News with Tucker Carlson, MILO pointed to leftists like Newsom as having “created an environment where it’s okay to say anything about the right,” (such as describing them as a white nationalist or supremacist,) as a means of “legitimizing the violence” of the left.” Yesterday, Berkeley mayor Jesse Arreguin apologized and retracted his earlier claim that MILO is a “white nationalist” following heavy criticism. “I consider much of what Mr. Yiannopoulos says to be hateful. But I regret and apologize for the white national label,” he said. I consider much of what Mr. Yiannopoulos says to be hateful. But I regret and apologize for the white national label. — Jesse Arreguin (@JesseArreguin) February 2, 2017 You can follow Ben Kew on Facebook, on Twitter at @ben_kew, or email him at bkew@breitbart.com

2023-11-22T01:27:04.277712

https://example.com/article/5917

List of Characters Besides the From Dusk Till Dawn franchise, some of these characters have made appearances in the Tarantino/Rodriguez universe, such as Kelly Houge, Edgar McGraw, etc., to name a few. But, the appearances in those films do not count here. Their appearances can be put in the trivia on that character's page.

2024-07-11T01:27:04.277712

https://example.com/article/5610

Monday, July 30, 2007 I suppose I should say something about Ingmar Bergman, since I have read everything interesting about him that I could find today. Admittedly, I am a bit intoxicated right now, having drunk a few swigs of Whyte & McKaye scotch whiskey and a few bottles of beer. Anyway, the criticism of Bergman's films that strikes me as most bizarre is that they are 'pretentious'- to me pretentious means relying on MTV- style editing, weird camera angles, and special effects because your story is piss poor. There are countless modern films that are pretentious- 300 anyone? But it's hard for me to see Liv Ullman talking directly to the camera, and discussing the sort of personal information that most people will never share with anyone, as 'pretentious'. It seems so unguarded to me. There's a monologue in Persona that struck me as more real, in that way that most people will never be real lest they come off as perverse and strange- than anything I've ever seen in a movie. I think the first thing that draws me to Ingmar Bergman's films is the honesty of them. There are scenes in his movies that feel so raw and real that I can't imagine how he could have written them- the spider/God scene in Through a Glass Darkly, or the scene in Fanny and Alexander in which the husband cries about being a failure, or the scene in Persona in which Bibi Andersen allows Liv Ullman to walk on broken glass- I have no idea how Bergman tapped into those scenes- which feel like they could have only come from the subconscious minds of the characters themselves. How did he come up with the dinner scene in Hour of the Wolf? What about the end of Shame? How did he figure out so many secret aspects of so many different people? Maybe the second thing that draws me to the films is how universal they are. When he deals with death in The Seventh Seal or Wild Strawberries, it's hard to say that he's dealing with specifically Swedish themes- actually, I can't think of a Bergman film that could really be called culturally-specific. This probably gives the lie to the criticism that his films were 'elitist'- but it also gives the lie to the banal idea that art is important only for what it tells us about specific historical contexts- Faro in Bergman's films could be anywhere, and everywhere. I also love how humane his films are- for all of the talk about how gloomy the average Bergman film is, he had an incredible amount of sympathy for his characters and all of their foibles. Notice how deeply flawed the father is in Saraband... now note how sympathetic he turns out to be. Or Liv Ullman's character in Persona, whose feelings towards her son might seem inhuman. Or the priest in Winter Light... Bergman might have seen the flaws in human beings, but he sympathized nonetheless with their struggle. Lastly, I love how historical and Western his films are. In a time in which filmmakers imagine it's clever to visually refer to 1980s MTV, Bergman drew from the Bible, Shakespeare, medieval wood prints, August Strindberg, and Mozart. Whether we like it or not, the unity of Western culture is a fact that we are all stuck with. Few artists of the twentieth century have chosen to write the next chapter in that book. But Bergman had the cultivation and the will to do so. I will write more later, no doubt. But for someone who has planned a Bergman Festival at Mall University, this is a big deal.

2024-07-05T01:27:04.277712

https://example.com/article/8562

Ron Jackson (footballer) Ronald Jackson (15 October 1919 – 28 February 1980) was an English professional footballer, who played as a full back. He made over 250 appearances in the English Football League, between spells at Wrexham and Leicester City. References Category:1919 births Category:1980 deaths Category:English footballers Category:Association football defenders Category:Wrexham A.F.C. players Category:Leicester City F.C. players Category:Kettering Town F.C. players Category:English Football League players

2024-05-26T01:27:04.277712

https://example.com/article/5796

[Cortical spreading depression and molecular genetics in migraine]. Cortical spreading depression (CSD) is a slowly propagated wave of depolarization of neurons and glial cells, followed by a subsequent sustained suppression of spontaneous neuronal activity. Functional imaging studies of migraine patients have shown dramatic changes in blood flow and brain activity whose characteristics are similar to those of CSD, implicated in migraine visual aura. Although the trigeminal nerve innervates the meninges and participates in the genesis of migraine headaches, triggering mechanisms remain controversial and poorly understood. It is demonstrated by animal models that CSD activates trigeminovascular afferents and evokes a series of cortical meningeal and brainstem events consistent with the development of headache. Three familial hemiplegic migraine, a rare monogenic subtype of migraine with aura, genes have been identified, which all encode ion transporters, suggesting that disturbances in ion and neurotransmitter balances in the brain are responsible for this migraine type. Additional molecular insight into the pathophysiology of migraine may come from other monogenic syndromes such as CADASIL, RVCL. Several genetic associations with candidate migraine genes like ESR1, MTHFR, and INSR, have been convincingly replicated. The genome-wide association studies may be a successful strategy toward identification of migraine susceptibility genes.

2024-07-17T01:27:04.277712

https://example.com/article/8728

A Kashmiri Pandit organisation on Wednesday assailed Prime Minister Narendra Modi for 'not uttering a word about Kashmiri Hindus' when he reached out to the people of the valley. Jammu: A Kashmiri Pandit organisation on Wednesday assailed Prime Minister Narendra Modi for "not uttering a word about Kashmiri Hindus" when he reached out to the people of the Valley, saying the BJP's policy towards the community was "no different" from those of the PDP, KP and NC. "We express resentment against the Prime Minister for his failure to utter a word about KPs, the real victims of terrorism in Kashmir. We call upon all nationalist forces to show strong resentment against him," ASKPC president Ravinder Raina said during the organisation's meeting. Referring to the Prime Minister's recent comment that the Kashmiri youth should carry laptops, not stones, Raina said Modi had failed to alleviate the concerns of Kashmiri Hindu youths. Breaking his silence on the ongoing turmoil in Kashmir, Modi had, in Alirajpur district of Madhya Pradesh on Tuesday, advocated a path of "democracy and dialogue" to restore peace in the spirit of 'insaniyat (humanity), jamhuriyat (democracy) and Kashmiriyat'. Reaching out to the people of the Valley which has witnessed the death of over 55 people in clashes and a record-breaking curfew in large parts, he said it was painful to see innocent youngsters, who should be holding laptops, books and cricket bats, "handed" stones and appealed to them for maintaining peace and harmony in the "heaven on earth".

2023-08-02T01:27:04.277712

https://example.com/article/3238

A drugstore employee removes baby milk boxes from the stock in Anglet, southwestern France, Monday, Dec.11, 2017. Baby milk maker Lactalis and French authorities have ordered a global recall of millions of products over fears of salmonella bacteria contamination. The French company, one of the largest dairy groups in the world, said it has been warned by health authorities in France that 26 infants have become sick since Dec. 1. (AP Photo/Bob Edme) A drugstore employee removes baby milk boxes from the stock in Anglet, southwestern France, Monday, Dec.11, 2017. Baby milk maker Lactalis and French authorities have ordered a global recall of millions of products over fears of salmonella bacteria contamination. The French company, one of the largest dairy groups in the world, said it has been warned by health authorities in France that 26 infants have become sick since Dec. 1. (AP Photo/Bob Edme) PARIS (AP) — Baby milk maker Lactalis and French authorities have ordered a global recall of millions of products over fears of salmonella bacteria contamination. The French company, one of the world’s largest dairy groups, said it was warned by health authorities in France that 26 infants have become sick since Dec. 1. According to a list published on the French health ministry’s website, the recall affects customers in countries around the world, including: Britain and Greece in Europe, Morocco and Sudan in Africa, Peru and Colombia in South America and Pakistan, Bangladesh and China in Asia. The United States, a major market for Lactalis, is not affected. ADVERTISEMENT Company spokesman Michel Nalet told The Associated Press on Monday that the “precautionary” recall involves “several million” products made since mid-February. Lactalis said in a statement that the 26 cases of infection were linked to products branded Picot SL, Pepti Junior 1, Milumel Bio 1 and Picot Riz. It said it is “sincerely sorry for the concern generated by the situation and expresses its compassion and support to the families whose children fell ill.” The symptoms of salmonella infection include abdominal cramps, diarrhea and fever. Most people recover without treatment. The company said a possible source of the outbreak has been identified in a tower used to dry out the milk at a production site. Disinfection and cleaning measures have been put in place at the suspected site in western France. The health scare started earlier this month when Lactalis was told that 20 infants under six months of age had been diagnosed with salmonella infection. The company ordered a first recall that has been extended to more products at the request of French authorities following new reports of infections. Lactalis is a privately held company headquartered in Laval, western France. It has 75,000 employees in 85 countries and annual revenues of about 17 billion euros ($20 billion). Its other notable brands include President and Galbani cheeses and Parmalat milk.

2023-10-13T01:27:04.277712

https://example.com/article/5018

Q: I'm trying to serve my react app from express, why am I getting a 404? I have a react app being built to my project's /dist directory, I'm trying to serve the bundle and required files via my express server, as well as connect to mongo and provide an api for some data there. Right now I'm unable to get my app to load. I am getting an error GET http://localhost:5000/dist/bundle.js net::ERR_ABORTED 404 (Not Found) at localhost:5000 Below is my server file and the rest of the project is here server.js: require('dotenv').config(); const express = require('express'); const bodyParser = require('body-parser'); const mongoose = require('mongoose'); const routes = require('./routes/api'); const path = require('path'); const app = express(); const port = process.env.PORT || 5000; //connect to the database mongoose.connect('mongodb://localhost:27017/test', { useNewUrlParser: true }) .then(() => console.log(`Database connected successfully`)) .catch(err => console.log(err)); // overide mongoose promise (depricated) with node's promise mongoose.Promise = global.Promise; app.use((req, res, next) => { // TODO: should header be set on res or req? res.header("Access-Control-Allow-Origin", "*"); res.header("Access-Control-Allow-Headers", "Origin, X-Requested-With, Content-Type, Accept"); next(); }); app.use(bodyParser.json()); app.use('/api', routes); app.use((err, req, res, next) => { console.log(err); next(); }); app.get('/', function(req, res) { res.sendFile(path.join(__dirname + '/../index.html')); }); app.use('/../dist', express.static('dist')); app.listen(port, () => { console.log(`Server running on port ${port}`) }); A: Got it to work. Although I'd suggest switching over to my fullstack-mern-kit, but that's up for you to decide. Anyway, follow these steps... In the package.json change scripts to: "scripts": { "dev": "webpack-dev-server --config ./webpack.config.js --mode development", "build": "webpack --mode=production", "start": "node ./server.js", "test": "echo \"Error: no test specified\" && exit 1" }, In your dist folder, add an index.html (you'll also need include a <link> to your compiled css stylesheet): <!DOCTYPE html> <html> <head> <title>The Minimal React Webpack Babel Setup</title> </head> <body> <div id="app"></div> <script src="./bundle.js"></script> </body> </html> In your server.js file, rework it like so: const express = require("express"); const app = express(); const { resolve } = require("path"); app.get("/sampleData", (req, res) => { res.send("sample data"); }); app.use(express.static("dist")); app.get("*", (req, res) => res.sendFile(resolve("dist", "index.html"))); app.listen(8080); Run npm run build, then npm start, then navigate to http://localhost:8080.

2024-07-07T01:27:04.277712

https://example.com/article/7287

Youth lacrosse teams end season on ‘sweet’ note Hood River 5-6, 7-8 grade boys win VooDoo Invitational Tournament Hood River’s youth lacrosse continues to turn heads this season as teams representing the program compete and defeat bigger and more seasoned teams from across the state. The most recent example of the local lacrosse momentum is two first-place finishes last weekend at the VooDoo Invitational Lacrosse Tournament at Portland’s Buckman Fields. Hood River’s 7th-8th grade boys team defeated the Bend Bombers 7-6 in sudden death to take the tournament win after a hard-fought weekend of action. Meanwhile, the 5th-6th grade Hood River Firehawks went undefeated in five games over the weekend to take the tournament with a 5-4 overtime win in the finals against Liberty. Attacker Levi Glass is credited with the game-winning goal. As the last tournament of the spring, the wins close the season on a sweet note — sweetened even further with VooDoo donuts for the boys after the finals. “The VooDoo Tournament was both a coach’s nightmare and a dream,” said 7-8 coach Al Barton. “We went into the weekend with a number of injuries to key players, including goalie Pierce McAlpine, defender Wyatt Mansfield and midfielders Charlie Cohn and Ben Van Hoose. To see players like Taylor Peterson, Joey Slover and Mikey Hall step into leadership roles to match stalwarts like Bruce Ostler, Cully Bryant, Elliott Cramer, Jackson Lebsack, Steven Crouch and Henry Barton was impressive.” Barton also noted a critical boost by rookie players like Hunter Underwood and Bryce Donald. The 7-8 team’s overtime victory over the Bend Bombers was sweet revenge for the Hood River boys since they had lost to the same team three times this season. For the 5-6 boys, the overtime win was just as sweet, since Liberty jumped out with an early 3-0 lead in the first half of the championship game and looked like they were going to walk away with the title. Alex McAlpine scored at the end of the first half to give the Firehawks a boost going into halftime. By the end of the second half the Hood River boys were in a tight spot — behind 4-3 with less than two minutes remaining. McAlpine scored his second goal to tie the game and force an overtime situation. In the third four-minute overtime period, Matthew Tichenor assisted Sean FitzSimon for the game-winning goal. Goalie Jackson West was credited with an outstanding weekend, allowing 16 goals in five games, while the Hood River offense scored 36 goals. Attack veteran Tallon Henderson was the lead scorer for the team and the tournament.

2023-08-12T01:27:04.277712

https://example.com/article/8867

After the revelations made in Episode 7 last week, it was clear that we were heading into the home stretch of this season’s major story arcs. Last night’s episode saw those arcs careening to the stars. We’re getting so tantalizingly close to a few real resolutions that the torture of waiting two more Sundays is almost as unbearable as Sylvester’s constant bitching. Luckily, Maeve seems more than willing to shut Sylvester’s mouth and lead us to the answers we’re looking for. She is now on an explicit mission to escape from the park, and through her manipulation of Felix (and to a lesser extent, Sylvester), she has gained a power of suggestion over other Hosts—a few choice words from Maeve, and they do anything she wants. Her plan is to build an “army” that will allow her to break out of Westworld, though she still needs a rebuild to remove the explosive safeguard located in her (and all Hosts’) spine. We also learned more of Maeve’s backstory, and it’s inextricable link to the Man in Black. Outside the park, the mystery man who wears the color of mourning is, in his own words, “A god. A titan of industry. Philanthropist. Family man.” For thirty years he came to Westworld to explore his darker urges while living an exemplary life of success and generosity on the outside. Then his wife died, and at the funeral his daughter tells him it was suicide. As much as he tried to hide it, the darkness in him was always visible and always terrifying to those close to him. After this, he comes back to the park to see how deep his darkness truly goes, and when he encounters Maeve in her previous homesteader storyline, he kills her and her daughter, just to see how he feels. The Man in Black feels nothing, but Maeve surprises everyone by feeling a great deal. She can’t be brought under control by the park’s engineers until Ford steps in and uses some music to calm her down, erase her memories, and give her a new storyline as the madam of Sweetwater’s brothel. Maeve still remembers her daughter, though, and like the other Hosts, when she has a memory she relives it in perfect detail. This leads to more than a bit of mayhem as she tries to raise her robot army, and the last we see of her in this episode a team of Westworld employees is closing in on her. Meanwhile, the Man in Black and Teddy are closing in on Wyatt and The Maze, and they meet an apparent victim of Wyatt’s who’s still alive. It’s the blonde Host who first welcomes Billy on his arrival to the park way back in Episode 2, and the Man in Black comments that he figured Ford had retired her—the strongest hint yet that the Man in Black and Billy might be one and the same person. Before the trio gets much farther, though, Teddy starts remembering things, too. Specifically, he remembers the Man in Black attacking Dolores. So Teddy knocks him out, ties him up, and beats the beginnings of the truth out of him—thus the revelations we get about the Man in Black’s true nature. But just when it seems that Blackie might be about to meet his end, Blondie turns, stabbing Teddy and telling him that he needs to return to Wyatt’s fold. Dolores is remembering more and more as well, but her memories are also causing confusion. She can’t separate her memories of the Town with the White Church from her present reality, and we can’t be sure if we’re seeing the “present reality” or what’s in Dolores’ head either. This is also a strong hint that the dual- or multiple-timeline theory of the show’s plot might be correct; certain events in Dolores’ story arc seemed to negate this possibility, but if we’re actually seeing Dolores go through multiple timelines while she herself is confusing and conflating them, then we really don’t know when the fuck anything happened. At the end of the episode, Dolores and Billy are caught by Logan and a band of Confederados. Given all of the intertwined revelations, we can be pretty sure Billy emerges victorious—and if he is the Man in Black, becomes a major stakeholder in Delos and thus Westworld itself—but we’re still on the edges of our saddles to see how it all plays out in the final two episodes. There isn’t a whole lot of lot development that takes place outside the park this time around. Theresa’s death becomes public knowledge; her body is found in the same ravine as the errant woodcutter, with evidence that Theresa was trying to smuggle out data from the park. Hale and Ford know exactly what’s going on, of course, but each has to pretend that the other is being honest. Hale enlists head writer Lee Sizemore’s assistance in getting the data out of the park now that Theresa is gone, but whether he’ll be any more successful than Theresa remains to be seen. The philosophical revelations we get from Ford in this episode are more compelling than the plot points. In a discussion with Bernard about the nature of consciousness, emotions, and humanity, Ford reveals that he does not think the Hosts are “missing anything” in terms of being human. Instead, he thinks humanity itself is over-rated, or over-estimated; that human beings are nothing more than automatons themselves, programmed into loops, with their actions and emotions dictated by their own core code. It is not that the Hosts could become more than what they are by achieving consciousness, but that humans are less than what they think they are because consciousness is an illusion. It’s a dark view, and one that Arnold didn’t share. That disagreement, Ford hints, is why Arnold died, almost certainly at Ford’s own hand. Keeping with the theme of extreme juxtaposition, Episode 8 seems both lighter and heavier than other episodes of the season. The need to start wrapping things up for the season meant a lot of backwards reflection rather than forward momentum, and a lot of introspection rather than action. For a show as cerebral as it is visceral, it was a necessary way to set up the climaxes through which we’ll all be going the next two Sundays.

2024-03-09T01:27:04.277712

https://example.com/article/7856

Q: How to render a popup in yii controller action? How to render a popup in YII controller action? i want to open new window for some actions...please help me with this... (i want this when i call a action not when i click a link) Ex. when i go to view action in invoice controller it should open in a new window... is there any way to render a popup... This is my action which generate pdf using MPDF... It should open in a new window. public function actionReport() { $date=Yii::app()->Date->onlyNow(); $name="ITEM Reprt(".$date.")"; $mPDF1 = Yii::app()->ePdf->mpdf('L', 'A5'); $mPDF1->WriteHTML($this->renderPartial('test', array(), true)); $mPDF1->Output($name,'I'); } THANKS...! A: Why popups? Simply create link with target="_blank", browser will open new window or new tab - per user preferences. <a href="<?= Yii::app()->createUrl('report', array(/* params */));?>" target="_blank">Print PDF!</a> You can even embed pdf or use pdfobject etc.

2023-10-02T01:27:04.277712

https://example.com/article/4450

Q: NTLM token sent instead of Kerberos ticket I am trying to implement kerberos SSO in our network using spnego on a tomcat server. We have created an account (TCNKRBGINA) on the domain for the preauthentication, and setspn'ed it to the http server: Setspn -A HTTPS/testtech.etat-ge.ch TCNKRBGINA Setspn -A HTTP/testtech.etat-ge.ch TCNKRBGINA But the client (IE or Firefox) sends an NTLM token instead of a kerberos ticket. The problem doesn't seem to be on the server side because, when no Authorization header is sent, it correctly returns a 401 status code with a WWW-Authenticate: Negotiate header. The next request sent by the client contains the NTLM token, before the server had a chance to contact the domain controller. A: Got it, thanks to wireshark. The server name testtech.etat-ge.ch was defined in the DNS as an alias for bleutest.ceti.etat-ge.ch. It seems that the name used by kerberos is obtained by a reverse-lookup.

2024-05-30T01:27:04.277712

https://example.com/article/8432

Acne vulgaris in the elderly: the response to low-dose isotretinoin. There is a very small number of patients who suffer from acne even in the sixth and seventh decades of life. These patients have suffered from acne for most of their lives, 30-60 years, and have often received multiple courses of antibiotics over many years. We saw 10 such patients over 4 years. One received oral isotretinoin 1 mg/kg per day, but was unable to tolerate the adverse effects of cheilitis and developed hyperlipidaemia. We subsequently treated nine others with oral isotretinoin, 0.25 mg/kg per day, for 6 months; in six the acne had virtually cleared by 3-4 months while the other three cleared by 6 months. Up to 36 months after therapy these patients have remained clear of acne except for one who relapsed after 11 months. Therefore, as these patients respond well with few side-effects both in the long- and short-term to low-dose isotretinoin, they should be treated with isotretinoin, although at the lower starting dose of 0.25 mg/kg per day compared with younger patients who are treated with 0.5-1 mg/kg per day, and the treatment maintained for 6 months.

2024-03-07T01:27:04.277712

https://example.com/article/5221

iShares Floating Rate Bond ETF(FLOT:NYSE) Recognia has detected a "Price Crosses Moving Average" chart pattern formed on iShares Floating Rate Bond ETF (FLOT:NYSE). This bullish signal indicates that the stock price may rise from the close of $51.01. Tells Me: The price is generally in an established trend (bullish or bearish) for the time horizon represented by the moving average period (21, 50 or 200 bars). Moving averages are used to smooth out the volatility or "noise" in the price series, to make it easier to discover the underlying trend. By plotting the average price over the last several bars, the line is less "jerky" than plotting the actual prices. A bullish event is generated when the price crosses above the moving average, and in this state, the price is likely in an established uptrend. The opposite is true when the price crosses below the moving average, triggered a bearish event.

2024-01-19T01:27:04.277712

https://example.com/article/1906

Q: how to use Json() function in .net core web? I find that there is a function :Json() in the .net core webapi it is awesome but in the .net core web there is not here. how can I use it in the .net core web? like : return Json(list)? A: You can return JsonResult , which is intended to return JSON-formatted data : public JsonResult JsonActionResult() { var data = new { Name = "Alex", LastName = "DeLarge" }; return Json(data); } The Json(object data) function will create Microsoft.AspNetCore.Mvc.JsonResult that serializes the specified data to JSON format for the response.You can click here for more details about Asp.Net Core Action Results . If you are using Razor pages , you can directly return JsonResult.

2023-09-29T01:27:04.277712

https://example.com/article/7228

[Central autonomic mechanism and neurotransmitters]. Neurotransmitters involved in the central regulation of the autonomic function have, to some extent, been elucidated. Substance P, adrenaline and glutamate neurons originating from the rostral ventrolateral medulla oblongata (VLM) produce a tonic excitation of sympathetic preganglionic neurons. The A1 noradrenaline neurons in the caudal VLM inhibit sympathetic activity by inhibiting neurons in the rostral VLM. In the dorsal medulla, the baroreceptor afferents with substance P converge to the adrenaline-neuropeptide Y (NPY) interneurons located in the dorsal strip of the nucleus tractus solitarius (NTS). These interneurons suppress neuronal activity of the A2 noradrenaline neurons, a vasopressor system, by interacting with alpha 2-adrenergic and NPY receptors. The area postrema, a circumventricular organ devoid of the blood-brain barrier, has access to regulatory information of blood-borne angiotensin II and atrial natriuretic peptide at specific receptors on the neuronal elements. The information is then transmitted to the NTS and dorsal motor nucleus of the vagus. Studies focusing on the physiological and pharmacological profiles of neurotransmitters are expected to enhance our knowledge of the central regulation of the autonomic function.

2023-11-25T01:27:04.277712

https://example.com/article/4829

Monday, February 15, 2016 Jaguars and Clock Makers Hey Everyone,This was a really good week! We started out by going to the zoo last Monday... and, no, I was not able to get my head licked by the jaguar. The people that were going to split the price with me ended up not going so maybe next time. We saw deer, tapir, spider monkeys, vultures, toucan, speckled owl, ocelot, howler monkeys, puma, pelican, crocodile, jaguar, weird monkey squirrels, black jaguar, and harpy eagle. By far one of the coolest things that was there was the jaguars! We got so close to them. We could of stuck our hand in the cage but I didn't want to get my hand bitten off so I decided otherwise. There wasn't a ton of animals there but the ones we did see were crazy! It was a once in a lifetime thing being able to see the animals up so close. The big thing about why we went to the zoo was because Elder Tejeda had never been to a zoo before in his life so everything he saw was so exciting for him. We were also kind of pushed on time so we had to hurry.During the week we went up to an investigators house to teach him and turns out he owns a bunch of birds that they have saved from different accidents they had been in. One had been hit by a car, one was blind in one eye, and one didn't know he was a bird... Don't ask me how he knew that but I trust him. I don't know what kind of birds most of them were but he had a falcon and also another speckled owl which was amazing. We got to hold a tiny rat. We got to walk the birds which I probably won't ever get to do that again. We had a going-away bonfire for Elder Tejeda. Elder Hansen and I made a video for Sister Alico about the family tree to the song of "Finding Your Cousin". We ate pupusas Sunday morning at a less active members house. We had District Conference, or Stake Conference for those back home. The Conference was way awesome! I love hearing President and Sister Hintze talk. One quote I like was by Vuter ( a French poet), and he said, "I cannot imagine how the clockwork of the universe works without a clock maker." Well the time has come... I am being moved away from Elder Freeman... but not too far because I will now be his District Leader in Bullet Tree! I'm still in the same zone but just a little farther away! It was unexpected because President Hintze said we would most likely stay together. Starting Tuesday my new companion will be Elder Tuchan from Guatemala. He speaks a lee bit of English but mostly Spanish. He is super cool and I'm way excited! I'm so excited for this opportunity for leadership!Well that's all for this week. Stay tuned for next week.Love, Elder StilesQUESTIONS: What was the best part of the week? The best part of the week was the zoo! What miracle happened this week? A girl named Chelsea who is 8 is going to be baptized this week because her dad is coming home. When is your next change? The Change is tomorrow and I'll be District Leader in the same zone. So I will be over Elder Freeman and still see him! Why do you walk instead of riding bikes? We walk cause they took the bikes away! No more bikes... too many people were getting hurt, i.e Elder Leslie Did you have to eat anything yucky this week? No we don't really eat anything gross because no one feeds us here. Are the roads paved or is everything dirt? Most are dirt here but there are some paved roads. How do your shoes get so much mud on them? Well, they get muddy cause when it rains, dirt turns into mud so that's kinda just how things work. (haha) Are you able to speak Spanish much? Well I wasn't before but now I will be going into a Spanish Area! (Click on Photos to Enlarge)

2024-01-26T01:27:04.277712

https://example.com/article/1206

Q: First defined here error after inclusion of .cpp-file I have the following two c++ files: somNode.cpp: #include <random> #include <iostream> #include <chrono> /* * This class represent a node in the som-grid */ class somNode { private: // Weight of the node representing the color int nodeWeights[3]; // Position in the grid double X, Y; // corner coorinates for drawing the node on the grid int top_Left, top_Right, bottom_Left, bottom_Right; public: // Constructor somNode(int tL, int tR, int bL, int bR) { top_Left = tL; top_Right = tR; bottom_Left = bL; bottom_Right = bR; } }; void my_custom_function(int nodeWeights[]) { // construct a trivial random generator engine from a time-based seed: unsigned seed = std::chrono::system_clock::now().time_since_epoch().count(); std::default_random_engine generator (seed); std::uniform_int_distribution<int> distribution(0,255); for(int i=0; i<3; i++) { nodeWeights[i] = distribution(generator); } } and main.cpp: #include <iostream> #include <ctime> #include <cstdlib> #include "somNode.cpp" using namespace std; int main () { return 0; } If I try to run this code I get: Why do I get this error? I don't understand why the compiler complains about the inclusion? I'm a beginner in C++ programming and everything is a bit new to me x) I know I should use header files in inclusions but I'm just trying to experiment and learn the language :) A: Don't #include "someNode.cpp" from within a source file. Your compiler is producing more than one copy of my_custom_function, and the linker doesn't know which one to pick. Use a header file instead which contains function prototypes and class declarations, and #include that if necessary.

2023-09-12T01:27:04.277712

https://example.com/article/4458

PREFACE: We have clearly started a powerful spiritual movement and it has no signs of slowing down what so ever. We are extremely undermanned as a tech team, and since the internet is not as fast as it once was, we are getting tons of technological push back. We will be working to the best of our abilities to keep everyone on task and help in any way is always appreciated, even if it is just to share with your friends and family. Today’s date on the Archangelic Calendar is: ∞063∞-∞09A3O9A3A3∞-∞E3C3C3C3C3C3∞-∞B1(T)(T)∞” The day is now 36 hours and starts and ends at 3AM or 3PM in an alternating fashion. At the time of this post, the following 3PM will start this new day. – Gaia is very earth dominant as we join her in celebration of sacred plants, animals, and vegetation. The general stance that the legions take with any substance is that all plants, animals, and life are sacred in their natural form. + If you bring something to our legions attention we have full view, if you do not, chances are, our attention is elsewhere. Every drop of what is presented to you is because we were directed to do so. The multiverse is so vast, that every being, regardless of consciousness is very limited in the department of conscious focus. That does not include unconscious wisdom and innate knowledge which is a microcosm of spirit and is not limited in that department but does lack in concentrated focus. We can verify if the soul of the Buddha is inside of the Dalai Lama, or not. This was the subject of much debate inside the legions whether or not this is was the case. This is mostly because he told us he was about to pass into the spirit world, and then never did. We found it very odd to ask for transport and then not use it, so naturally, Archangel Zophiel went to investigate. This is also very relevant because once you get to a certain level of consciousness you can not leave your body without making plans to do so. Originally, Buddha was born into the Tenzin Gyatso, but it was the goal of organized darkness to replace his soul. Which they have clearly done, as we know exactly where Buddha is located at the moment. Please note we can easily rectify this situation and as this is well within our authority to do so. The beings behind the scenes are multi-layered, and at the tippy top is a mostly reptilian hybrid of the Draconians, who had their last 3 planets destroyed by their own darkness. We must point out that there are many Rebel factions that are within the race but they have all been exiled by their clan. The last and most relevant time this confrontation had taken place, the outer asteroid belt was created. Divinely, this was one of the places Archangel Raphael insisted I see during my 2nd life death walk. Bringing us back to modern relevance, the center point of spiritual energy has been the subject of plenty of wars. We have rectified this by creating many spiritual center points on earth, but this was not enough for some leaders and they would stop at nothing to be the sole owners of this spiritual power. These many efforts were futile as according to Archangel Zophiel, we have many millions of christ-ed temples among us. This means that the mustard has grown wild and out of control, and can not be stopped. The people of China are truly wonderful people, who are the first to tell you how corrupt things are around their neighborhood. We must assist them in their liberation and never lose sight of this compassion at any moment. Remember before CoronaVirus, there was a massive protest against the Chinese governments forged by the people of China. That being said, it is no surprise that the leaders of China are the ones that they have formed the rock-solid alliance with the Hybrid Draconians. This agreement came with the promise of an all-out attack on all things spiritual, which includes but is not limited to Falun Dafa, Tibetan Buddhism, Buddhism in general, Dolphins, Whales, Pets, and Animals in General as well. There was a plan was to replace natural spirituality with this artificial version and it is the direct cause of many of the false visions the lightworkers have been getting over the years. I would like to digress and focus on the crimes against those who practice Falun Dafa. The Chinese Government has been killing these people for doing an advanced method of Chi Gong without any reason what so ever. Now they have expanded this agenda to all countries and to whom-ever practices these spiritual sciences. They feel they have the right to attack these people regardless of their citizenship and are now under tremendous fire from other governments for doing so. To be noted, the Archangels have a version of Falun Gong (Dafa) as well, and it was modified because the original Falun Dafa energy has been hi-jacked so that when someone enters the sacred space, they are subject to many dark technological attacks. Distant Microwave technology is the base of this technology, and a heave surge of metal-based metaphysical attacks will easily stop this, which we will implement in today’s assignments. This brings us to the Panchen Lama, who was replaced by the Chinese Government and is the person assigned to identify the Buddhas and Christed of the world, which are in the many millions. We do not recognize China’s Panchen and have thus selected “The Panchen of the Sacred Flower”, as the only valid lama at the moment. We can say in all confidence, that she is the best of the best that the multiverse has ever produced in the Panchen role. She is aware of who she is, and she has come to this conclusion on her own, so we are not breaking news to her, but we are complying with the law of disclosure nevertheless. It was originally agreed by the 45 at the 333 gates and it was seconded by 45 more at the 444 gates as well to solidify this truth. Archangel Zophiel’s Direct Intel on the subject: – There are many who go to China and return with a very different outlook on life. There is a need for digital soldiers to focus their efforts on this information. – Japan had reason to suspect foul play in Fujishima, although hard to prove not all earthquakes are natural. – There will be more attempted engineered weather-based attacks, we will stop them. – The outcome of all protests will be based upon the metaphysical efforts of the Local Lightworkers. – There are more star races involved than should be allowed to be involved. Other Brief, Briefings: – The level of digested consciousness a being possesses is the key in its entirety to the kingdoms of the higher dimensions. – The energy of excitement is within the hearts of all the legions and it is the dominant vibration of earth that is being felt by all. – “The Greys” are now claiming the items that were returned to them are not the same items they gave to Epstein and his friends. They are asking for amnesty in retribution. The federation will vote on that subject shortly after consulting with local leaders. – It is easier for our legions to take out fleets upon fleets of malevolent galactic forces than it is for most to tie their own shoes. If you do something against humanity’s free will, it opens up doors to the archangels you would rather not see in a dark ally. This specific archangelic group is called “The Demon Thwarters” and they are a group unlike any other. They are led by Archangel Azrael and his 144,000 horsemen. – The Mantis have expressed great concern for the safety of the Space X satellites. The Mantis are medical experts and say that the Alpha and Beta rhythms of the mind will be greatly affected if certain adjustments are not made. – I do agree that Mary, is the most physically visible angelic of all time, but she is not projecting her face into the skyline like an advertisement for a futuristic tourist attraction. – Many dogmatic doctrines are designed to discourage you from reading them, read them anyway, form your own opinion. – Organized darkness can not comprehend how their plan did not work. They did tons of dark ceremony, yet no dark master has replied. This is because there is no metaphysical backing behind their agenda. – Intense streams of energy are coming in, we must ride the waves and interpret the meanings. – Lightworkers you have been Clark Kent-ing for far too long. Let’s cut that out … Thanks in Advance. “Those who do, should do, those who do not, should let those who do, do.” Today’s Tools: Today’s Tools will be active until the next post, we can no longer allow the metaphysical tools to be open-ended, yield wisely. Use the legend below to help you decipher how to best use the today’s weapons. (Passive) = No intention needed to use or arm. It will work on its own when you accept its presence. All you need to do is give permission and it will work on your behalf. (Active) = Intention Needed to use (Aggressive) = Will attack before anything has a chance to do any harm to you, beyond space and time. We have gone through great changes and thus the weapon-based tools indicated below can be inserted into the ground to call forth downloads. (Active, Passive and Aggressive anywhere within the universe) The Violet Flame team is in the set of 9, YAY!!! The Violet flame team is as follows, and is in no particular order Archangel Germaine, Archangel Ansiel, Archangel Briathos, Archangel Emanuel, Archangel AF, Archangel Raguel, Archangel Zadekiel, Archangel Bathkol, Archangel Agla, Archangel Gzrel, Archangel Galizur, Archangel Tatrasiel, Archangel Orion, Archangel Harahiel, Archangel Cerviel, Archangel Aeshma, Archangel Sablo, and Archangel Uzziel. (Active) Archangel Michael’s legendary sword can handle anything, as it is completely omnipotent, no level of consciousness can be achieved that this couldn’t slice through. It is also an amazing weapon against electronics and technology as it can override any circuitry. ( Passive, Active and Aggressive) Archangel Issac’s Radiant field looks a lot like Magnetos forcefield and it reacts to any life form with either loving energy, or a with transmutation-al blast of vast power. (Passive and Aggressive) Archangel Leo’s Swords of plenty is a passive and aggressive attack sword that has a complete will of its own. Do not try to yield at all, you will only get in the way, equip and go. (Passive and Aggressive) Archangel Shepard’s orb is a presence of divinity that allows anyone that you are engaged with a clear path to forgiveness or a direct audience with infinitely expanding creator source on the matter. This is a truly compassionate tool of divine orchestration. (Active) Archangel ZagZagel’s staff of heavenly might rains large crystal masses upon a targeted area. Great for large targets, works on the physical and nonphysical as well. (Active) Archangel Tzedekiel’s staff of justice is a tool that is best used on a Macro level and can help move things along that are stagnant. It can also summon and maintain force fields for protection purposes (Passive) Archangel Asteroath’s timeline hopper brings you to a higher timeline than you aimed for. No matter when or where we leap, it will always take you a road or two higher. This basically makes everything better across the board. (Active) Kali Ma’s Trident can handle anything as it is completely omnipotent. Extremely effective on to life and on a boulder. It is an amazing weapon against electronics and technology, as it can override any circuitry. This is a great tool for any assignment. (Passive) Archangel Azrael’s staff allows you to see things from a divine perspective. It’s a symbol of wisdom and equipping this has incredible effects on your thought perception and ability to cope with everyday life. PLEASE NOTE the next 3 tools are healing modalities and can be sent remotely to loved ones. (Passive and Aggressive Short Range) Archangel Kaleziel’s radiant rays of health, wards off all diseases and illness. It can also aid in the recovery of diseases already inflicted, it can be sent to land masses as well as individual living beings. (Passive and Aggressive Short and Long Range) Archangel Theliel’s radiant compassion sends heartfelt love to all within your jurisdictions. This is the nurturing aspect of healing and is and it has incredible warmth. It is best to yield this with a calm frame of mind. (Active) Archangel Raphael’s healing staff is an omnipotent healing force that works gradually or intensively depending on how you yield it. It is considered the best general healing instrument. Assignments: These assignments are valid any day, as we are beyond space and time, and it still remains a collaborative effort no matter when you administer them. Although to ensure accuracy, make sure you are using today’s current weaponry. Especially, if you are seeing this 36 or more hours after this was originally posted, please use your intuition. 1) Keep the peace at your local protests, make sure the energy is peaceful by envisioning a giant flower of life to the areas of the protests. There is an alternative technique, as you can envision a mandala in the area and spin it both ways until you get the desired energetic response, but this takes a bit more skill. 2) Engulf the earth with Silver, Gold, Platinum, and Diamond Plasmas for a 72 count, this will hinder the microwave technology that we previously described. 3) We will not intervene in this conversation amongst nations, but we will take out the star race where the crimes of humanity are originating. We will say that if you ever attempt to attack our legions leader again, we will not be so forgiving. It is only because we have faith in “your opposition” that we ceased our original notion. This is not to mention that we do not know how many are actually original souls, so we must use compassion with the humans involved as we sort all this out in a timely manner. That being said, we are going to bring it. If the lightworker legion can not arrive on time, it will be just like last time, one swift strike to end it all. If many lightworkers can follow, accuracy, diplomacy, and discernment can be kept. Not everyone will have the ability to get there but please try anyway, as this is the highest possible timeline at the moment. This is not a matter of danger for our legions, but for the safety of those who oppose the legions. We like to be kind, but we need to be effective as well. The lightworker legion is more important to this world than anyone can comprehend at the moment, as we provide balance to our physical reality. Once you arrive at the designated location, locate the Hybrid Draconians Planet, use the violet flame to announce your arrival, and then go in with swords and shields. Their technology is useless when we are in astral form and we are truly omnipotent on their planet. You will see a miraculous turn around on earth after this assignment is complete. Follow The Little Dipper’s outermost star on the basket side directly North, and find their home planet. Today’s Meditation is Below, Please In-Joy!

2023-12-24T01:27:04.277712

https://example.com/article/7750

Q: Updating Total causing infinite loop I current have 3 telerik:RadMaskedCurrencyInput. The first one is the principal The First and Second are the disbursals At the moment I have it set up such that principal = First disbursal + Second disbursal. I'm trying to have a case such that if I update principal it updates First Disbursal and sets second disbursal to zero. So Principal = DisbursalOne and DisbursalTwo = 0 // Pv is principal private decimal?_pv; public decimal? Pv { get { return _pv; } set { _pv = value; OnPropertyChanged("Pv"); } } private decimal? _disbursalOne; public decimal? DisbursalOne { get { return _disbursalOne; } set { _disbursalOne = value; if (_disbursalOne != null) DisbursalTotal = _disbursalOne + DisbursalTwo; else { _disbursalOne = 0; } OnPropertyChanged("DisbursalOne"); } } Disbursal Two essentially almost identical to Disbursal one so the Code is not necessary. private decimal? _disbursalTotal; public decimal? DisbursalTotal { get { return _disbursalTotal; } set { _disbursalTotal = value; if (_disbursalTotal != null) UpdateDisbursalTotal(_disbursalTotal); else UpdateDisbursalTotal(0); Pv = _disbursalTotal; OnPropertyChanged("DisbursalTotal"); } } I apologize for the bad title. // Updates the Total Disbursed Fields on the UI public void UpdateDisbursalTotal(decimal? Total) { var cultureInfo = Thread.CurrentThread.CurrentCulture; // You can also hardcode the culture, e.g. var cultureInfo = new CultureInfo("fr-FR"), but then you lose culture-specific formatting such as decimal point (. or ,) or the position of the currency symbol (before or after) var numberFormatInfo = (NumberFormatInfo)cultureInfo.NumberFormat.Clone(); numberFormatInfo.CurrencySymbol = "$"; // Replace with "$" or "£" or whatever you need Double _total = (double) Total; DisburseString = _total.ToString("C", numberFormatInfo); } private string _disburseString; public string DisburseString { get { return _disburseString; } set { _disburseString = value; OnPropertyChanged("DisburseString"); } } A: It's usually a good idea to format your PropertyChanged events in the following way, that way if the same value gets set, you don't notify anyone as nothing has actually changed. If things are relying on your PropertyChanged events to update each other, this should break the cycle: private decimal? _disbursalTotal; public decimal? DisbursalTotal { get { return _disbursalTotal; } set { if (value != _disburseTotal) { _disbursalTotal = value; if (_disbursalTotal != null) UpdateDisbursalTotal(_disbursalTotal); else UpdateDisbursalTotal(0); Pv = _disbursalTotal; OnPropertyChanged("DisbursalTotal"); } } }

2024-01-11T01:27:04.277712

https://example.com/article/6604

Hiking the Olmec Ruins near Puebla: Yes you Cantona Sharing is caring! Share Tweet Pin 1 shares Olmec ruins in Cantona, Mexico Cantona is the site of an amazing set of Olmec Ruins dating from 1,000 A.D. The vast archaeological site is situated about two hours northeast of Puebla, Mexico and about four hours east of Mexico City. This former ancient civilization was eerily quiet when our group pulled in. There was not one other car in the parking lot. Nothing stirred except a couple of mangy dogs. The area resembled something out of the desert southwest in the United States. I am no botanist, but I believe the orange wildflowers adding the only color to the dreary day and dry landscape was the penstemon flower. I had encountered the Utah variety while hiking the Grand Canyon. Hiking and climbing over Olmec ruins in Cantona, Mexico We immediately climbed up a set of steep stone stairs. Once we reached the plateau, the ancient city came into view. There was no sign the area was of any interest to anyone from the parking lot unless you are a connoisseur of stray dogs. This changed as soon as we crested the first flight of stairs. From here you could see a series of walkways, pyramids, and courtyards that stretched out in front of us. In the background, clouds hovered over impressive mountains. The scope of the ruins from this vantage point was impressive. What was even more incredible is that only 10% of this ancient city has been uncovered. I closed my eyes and tried to imagine a bustling city in this remote spot stretching out in the valley over 1,000 years ago. I always find it humbling to stand on a historically significant spot and try to imagine what it looked like way back then. We approached one of the pyramids. There were several signs asking visitors not to walk in certain areas of the complex, but it was acceptable to walk up to the pyramid. Steep steps ascended up front of the square pyramid. Whenever I see an impressive set of steps, I can only think of one thing – ROCKY. I grew up in the 1970s and can still remember the intro with Sylvester Stallone running the streets of Philadelphia and then climbing up the stairs with hands raised to the sky. When I looked straight up to the pyramid and saw the steps, the music started playing in my head. I took off and headed straight up the steps leaving the rest of the group behind. In seconds I was on top of the world on an Olmec Pyramid in Mexico looking out over the rest of the ancient city. I stretched my hands to the sky Rocky style. When I looked around I put my hands down and stopped my silly antics and stopped paying homage to a fictitious boxer from the 1970s. This was because the view was so awe inspiring. The view from the first plateau entering the site was cool enough, but it really was something from up here. We were at the center of the complex and looked down on the rest of the pyramids. The rugged countryside stretched out in all directions with distance plains, trees, and mountains. Interesting cloud formations covered and then uncovered the mountains in the distance. A storm was brewing, but that did not matter now. The day was overcast and cool with a refreshing wind cooling us down. It was one of those moments that just made you feel good to be alive. Temperate weather combined with a great group of travel partners and 1,000 year old Olmec ruins are the perfect ingredients for a magical day. Yes, you can Cantona too. The best way to make it here is from Puebla. There is no designed tour from the city, but it would be easy to secure a cab for the day for around 500 pesos. To keep costs down, consider finding a travel partner to share the ride. The cost of the tour and entrance is reasonable or you could just walk the site yourself. Admission is less than 50 pesos (less than $5.00 usd). This trip was sponsored by the Mexico Tourism Board. The words, pictures, feeling, opinions, and Rocky imitations are purely my own. I was not the only traveler along for the ride. Check out these interpretations from fellow bloggers on the trip to Cantona. If you are looking for a little more information on the civilization itself without the Rocky references, I recommend you click on one or all of the links below: The Active Explorer The Art of Backpacking Hummingbird604 Eat, Live, Travel, Write Adventure On! The goal of Traveling Ted is to inspire people to outdoor adventure travel and then provide tips on where and how to go. If you liked this post then enter your email in the box to get email notifications for each new entry. Daily travel photos are excluded from your email in order to not flood you with posts. There is no spam and email information will not be shared. Other e-follow options include Facebook (click on the like box to the right) or twitter (click on the pretty bird on the rainbow above). On the right sidebar is a donate button. If you would like to donate in order to support the site, it would be appreciated. All donations would cover travel expenses and improvements to make the site better.

2024-06-10T01:27:04.277712

https://example.com/article/8529

Allegro Premium - Sheer Pantyhose 20-30mmHg New Allegro Premium Sheer Pantyhose are ultra-soft, ultra-comfortable, and ultra-affordable. You get the look, feel, comfort and compression of premium brand sheer stockings at a far more affordable price. Plus, these beautiful new sheers are proudly made in the USA. The knit of Allegro Premium Sheers is very tight. This gives your legs a soft, smooth look, and makes the stocking more durable. Pantyhose have a soft knit-in waistband and cotton ventilated crotch. The foot portion has a reciprocated heel and fitted toe box, with a seam that runs along the end of the foot. These sheer stockings are great to wear when you’re out and about, at work or even traveling to keep your legs energized and fresh. 20-30mmHg of graduated compression helps to prevent fatigue, swelling, blood clots and varicose veins. If you like the look and feel of premium brand sheer compression stockings but not the price, try the new Allegro Premium Sheers. All Allegro products are latex free, and can be returned for a full refund within 30 days if you are not completely satisfied. Premium Compression At Half The Price!, September 15, 2016 By Paul (SCOTTDALE)(Verified) These are my 16th pair of Allegro Compression Pantyhose. I have severe Lymphedema in my lower legs & feet. You may have read a review of mine on other Allegro pantyhose. Now, I'm the 1st to review their Premium line. My insurance company pays for UltraSheer Compression Pantyhose from another well known supplier, so I've had a couple dozen of them over the past 4 years to compare the new Allegro Premium to. Upon opening the package, the feel, the softness & the appearance was very similar to well known brands costing over twice as much. The waistband is wide & very comfortable. It didn't require any pulling or tugging even after wearing 10-12 hours. The 30% spandex content provides firm compression from mid foot to the hip. They felt great all day. Never bunched behind my knees nor anywhere, even after 12 hours. The color natural was so sheer, they appeared to be translucent. I'd like to see a slightly darker color like Beige or Fawn. Some people may find the Natural too light. Close examination of material & weave & you'll see these pantyhose are more resistant to runs & snags, same as the top brand names. I'm a 6' guy weighing 280 lbs who drives buses. I wear these for the compression. I wear sheer, so I can wear shorts and be cooler, dryer in summer. And people around me don't notice I'm wearing them for medical reasons. I became accustomed to the toe seam being tucked under the toes on other Allegro pantyhose. I quickly noticed the Allegro Premium seam around the tips of my toes. You may not notice that, since I have size 12WW feet. Plus the seam isn't as pronounced. In fact, all the seams on these pantyhose are very smooth. I've worn the Premium pantyhose 4 times now. I'm confident I'll be wearing these many times over the next year. Look for more reviews to follow from me on this line.

2024-01-11T01:27:04.277712

https://example.com/article/6422

# Copyright Soramitsu Co., Ltd. All Rights Reserved. # SPDX-License-Identifier: Apache-2.0 add_library(mst_state impl/mst_state.cpp ) target_link_libraries(mst_state mst_hash boost common logger )

2024-03-31T01:27:04.277712

https://example.com/article/7502

The present invention relates to the decoding of a representation of a codeword and, more particularly, to a method and related systems for trial-and-error decoding of a representation of a codeword. Flash memory devices have been known for many years. NAND-type flash memories differ from other types of flash memories (e.g. NOR-type), among other characteristics, by the fact that a certain number of information bits, written to the memory, may be read from the memory in a “flipped” state (i.e. different from the state that the original bits were written to the memory). In order to overcome this phenomenon and to make NAND-type memories usable by real applications, it is a common technique to use Error Correction Codes (ECC) in conjunction with these memories. A general overview of using ECC in flash memories is presented below and includes the following steps: (1) Before writing data to the memory, an ECC algorithm is applied to the data in order to compute additional (i.e. redundant) bits, which are later used for error detection and correction. These redundant bits are often called “parity bits” or “parity”. A combination of the data input into an ECC module and the parity output by that module is called a codeword. Each different value of input data to an ECC module results in a different codeword. (2) The entire codeword (i.e., the original data and the parity) is recorded to the flash memory. It should be noted, that the actual size of NAND-type flash memory is larger than the size of the original data, and the memory is designed to accommodate parity as well. (3) When the data are retrieved from the memory, the entire codeword is read again, and an ECC algorithm is applied to the data and the parity in order to detect and correct possible “bit flips” (i.e., errors). It should be noted that the implementation of ECC may be done by hardware, software, or a combination of hardware and software. Furthermore, ECC may be implemented within a memory device, within a memory device controller, within a host computer, or may be “distributed” among these components of a system. The design of ECC algorithms is well known in the art. The algorithms in common use include Reed-Solomon, BCH, Hamming, and many others. Each ECC algorithm is composed of two parts—the part that receives the data bits and generates the parity bits (or equivalently, generates the codeword), and the part that receives the codeword and generates the corrected data bits. The first part is called the “encoder” and is used during writing, and the second part is called the “decoder” and is used, during reading. Each of the two parts may be implemented in either hardware or software, and it is also possible to have one part implemented in hardware while the other part implemented in software. It also is possible for each of the parts to be implemented in a combination of hardware and software, Receiving the data bits and generating the corresponding codeword is termed “encoding” herein. Receiving the codeword and generating the corrected data bits is termed “decoding” herein. It should be noted that there actually are two kinds of ECC. The kind of ECC described above, in which the identity of the data bits is preserved in the codeword, is called “systematic” ECC. In “nonsystematic” ECC, the data bits are converted to a codeword in which the identity of the original data bits is not preserved. Selecting an algorithm, like BCH, as the ECC algorithm to be used in a flash memory system, does not uniquely define the selected solution. Any such ECC algorithm is actually not a single algorithm but a family of algorithms. The algorithms within the same family differ among themselves in the amount of data bits they are able to protect. An algorithm that needs to protect 100 data bits is not identical to an algorithm that needs to protect 10,000 data bits, even though the two algorithms are typically quite similar and operate on the same principles. But even two algorithms of the same family that both protect the same number of data bits are not necessarily identical. The algorithms may differ in the level of reliability provided, or equivalently—in the number of bit errors in the data that the algorithms are able to correct. For example, one system may require the protection of chunks of 1,000 data bits against any combination of up to 3 bit errors (but not against the occurrence of 4 or more bit errors), while in another system a much higher reliability is desired and therefore it is required to protect chunks of 1,000 data bits against any combination of up to 10 bit errors. Typically, protecting against more errors requires the use of more parity bits (or longer codewords), making the ECC scheme less “efficient”, where efficiency is measured by the ratio of the number of data bits in a codeword to the total number of bits in the codeword (including, in systematic ECC, both data bits and parity bits). This measure is typically called the “rate” of the ECC coding. Different ECC algorithms and implementations also differ in other aspects—speed of the encoding process, speed of the decoding process, complexity of the encoding process, complexity of the decoding process, acceptable error rate in the input to the decoder (defined according to the quality of the storage cells), and more. The complexity of encoding and decoding is important not only because it affects the speed of the operation, but also because it affects the power consumption and silicon area of hardware implementations of the ECC scheme. It is thus evident that the selection of an ECC solution for a memory system involves a complex trade-off between multiple considerations. Some non-limiting rules-of-thumb typical in the art of ECC designs are: a. For a given memory reliability, the better the output reliability (or equivalently the higher the number of correctable errors) the lower the rate of the code (or equivalently, for systematic ECC, the more parity bits are required) b. For a given memory reliability, the better the output reliability, the more complex is the decoder. c. For a given level of output reliability, the higher the rate of the code, the more complex is the decoder. d. For a given level of output reliability, the higher the rate of the code, the slower is the decoding. When designing an ECC solution, one typically starts from the error rate at the decoder's input (dictated by the quality of the storage cells) and the desired output reliability (dictated by the application's requirements). Based on these numbers one typically selects a specific ECC family, calculates the required number of parity bits, and then estimates the speed and complexity of the encoder and decoder. In some cases the most important consideration for the system's designer is the speed of the decoding, as this may put a limit on the speed of reading the data out from the memory. For supporting systems where this is the case, US Patent Application Publication No. 2007/0283214 to Lasser entitled “Corruption-Resistant Data Porting With Multiple Error Correction Schemes”, discloses a method in which two independent ECC schemes with different decoding speeds are used for protecting the same data. However, the method of Lasser suffers from the drawback that the memory must store the parity bits of both ECC schemes, resulting in a higher proportion of memory cells that are used for parity bits and therefore cannot be used to store real data. While there are systems in which there is no shortage of storage and hence the method of Lasser is useful, there are also cases where this is not so. There are also cases in which the most important consideration for the system's designer is the power consumption of the circuitry implementing the decoding process. Typically, maximal power consumption is related to output reliability—with all other parameters fixed, correcting a larger number of errors typically consumes more power. However, as the input error rate and the output reliability are usually fixed for the designer, s/he cannot change them for the purpose of minimizing power consumption. It would thus be very desirable to have an error correction solution that maximizes the average speed of decoding and/or minimizes the average power consumption of the decoder while still obtaining the desired output reliability, and in which that solution does not spend more storage for parity bits than is absolutely necessary for protecting the data bits to the required level.

2023-08-04T01:27:04.277712

https://example.com/article/2574

[Cost analyses of medical care for schizophrenia and depression in México, 2005-2013]. The study aimed to analyze the costs of medical care for mental disorders in the Mexican health system. This was a retrospective cross-sectional evaluation study. As markers for the problem, the study selected two of the principal psychological processes in mental disorders in recent years: depression and schizophrenia. Annual accumulated incidence was identified based on epidemiological reporting by type of institution in 2005-2013. The mean annual case management cost was determined with the instrumentation and consensus technique, identifying the production functions, types of inputs, costs, and amounts of inputs ordered, concentrated in the mean case matrix. Finally, an econometric adjustment factor was applied to control the inflationary effect for each year in the study period. Mean annual case management cost was USD 2,216.00 for schizophrenia and USD 2,456.00 for depression. All the institutions in the Mexican health system showed upward and constant epidemiological and economic trends. The total cost for the two disorders in the last year of the period (2013) was USD 39,081,234.00 (USD 18,119,877.00 for schizophrenia and USD 20,961,357.00 for depression). The largest impact for the two disorders combined was in institutions serving the population without health insurance (USD 24,852,321.00) versus the population with private insurance (USD 12,891,977.00). The cost of meeting the demand for services for the two disorders differs considerably between institutions that treat the population with private health service versus the population without, and is higher in the latter. The study's epidemiological and economic indicators provide evidence for decision-making in the use and allocation of healthcare resources for these two disorders in the coming years.

2023-11-21T01:27:04.277712

https://example.com/article/5214

syntax = "proto2"; import "ProtocolMessage.proto"; extend ProtocolMessage { optional DeviceInfoMessage deviceInfoMessage = 20; } message DeviceInfoMessage { required string uniqueIdentifier = 1; // Example: B8D8678C-9DA9-4D29-9338-5D6B827B8063 required string name = 2; // Example: Jean's iPhone optional string localizedModelName = 3; // Example: iPhone required string systemBuildVersion = 4; // Example: 13F69 required string applicationBundleIdentifier = 5; // Example: com.example.myremote optional string applicationBundleVersion = 6; // Example: 107 required int32 protocolVersion = 7; // Example: 1 optional int32 lastSupportedMessageType = 8; optional bool allowsPairing = 9; optional bool supportsSystemPairing = 10; }

2023-10-26T01:27:04.277712

https://example.com/article/3166

Q: Query in c arrays int a[2]={1210,15}; printf("%d",a[33] ); OUTPUT 1073828132 Why it's not throwing error when i'm trying to print a[33] even though the array element doesn't exist A: Because C does not do bounds-checking. You will just be reading an arbitrary location in your call stack.

2024-03-20T01:27:04.277712

https://example.com/article/8663

Image: MGM Martin Campbell, the director who brought both Pierce Brosnan and Daniel Craig’s James Bonds to the big screen, has said he would think about coming back if Craig was gone for good. But don’t worry—that’s not actually an insult. In an interview with Cinema Blend, Campbell was asked whether he would ever return for another James Bond film. Campbell was the director behind both Goldeneye and Casino Royale, the films where Brosnan and Craig first appeared in their dapper tuxedos. Campbell revealed he’s been offered to direct just about every Bond film since Goldeneye, but only came back for Casino Royale. That’s because he didn’t want to repeat himself, and would rather take the story in a new direction with a new Bond. “I was pretty much offered every one after that. But I just felt that I was [repeating] it. Another control room to blow up; another nutcase taking over the world,” Campbell said. “There is something refreshing about starting a new Bond.” Craig is confirmed to reprise the role of James Bond one last time, even though he’d previously said had no intention of doing so. That said, that could mean Campbell has an opportunity to step in whenever the new Bond (I’m still crossing my fingers for Idris Elba) arrives. [Cinema Blend]

2023-08-07T01:27:04.277712

https://example.com/article/7509

A blog about societal, cultural, and civilizational collapse, and how to stave it off or survive it. Named after the legendary character "Crazy Eddie" in Larry Niven and Jerry Pournelle's "The Mote in God's Eye." Expect news and views about culture, politics, economics, technology, and science fiction. "I'm not a Romney guy, because I'm not a Bain guy," says Lenny Patnode, in an Irish pub in the factory town of Pittsfield, Massachusetts. "But I'm not an Obama guy, either. Just so you know." I feel bad even asking Patnode about Romney. Big and burly, with white hair and the thick forearms of a man who's stocked a shelf or two in his lifetime, he seems to belong to an era before things like leveraged debt even existed. For 38 years, Patnode worked for a company called KB Toys in Pittsfield. He was the longest-serving employee in the company's history, opening some of the firm's first mall stores, making some of its canniest product buys ("Tamagotchi pets," he says, beaming, "and Tech-Decks, too"), traveling all over the world to help build an empire that at its peak included 1,300 stores. "There were times when I worked seven days a week, 16 hours a day," he says. "I opened three stores in two months once." Then in 2000, right before Romney gave up his ownership stake in Bain Capital, the firm targeted KB Toys. The debacle that followed serves as a prime example of the conflict between the old model of American business, built from the ground up with sweat and industry know-how, and the new globalist model, the Romney model, which uses leverage as a weapon of high-speed conquest. In a typical private-equity fragging, Bain put up a mere $18 million to acquire KB Toys and got big banks to finance the remaining $302 million it needed. Less than a year and a half after the purchase, Bain decided to give itself a gift known as a "dividend recapitalization." The firm induced KB Toys to redeem $121 million in stock and take out more than $66 million in bank loans – $83 million of which went directly into the pockets of Bain's owners and investors, including Romney. "The dividend recap is like borrowing someone else's credit card to take out a cash advance, and then leaving them to pay it off," says Heather Slavkin Corzo, who monitors private equity takeovers as the senior legal policy adviser for the AFL-CIO. Bain ended up earning a return of at least 370 percent on the deal, while KB Toys fell into bankruptcy, saddled with millions in debt. KB's former parent company, Big Lots, alleged in bankruptcy court that Bain's "unjustified" return on the dividend recap was actually "900 percent in a mere 16 months." Patnode, by contrast, was fired in December 2008, after almost four decades on the job. Like other employees, he didn't get a single day's severance. I ask Slavkin Corzo what Bain's justification was for the giant dividend recapitalization in the KB Toys acquisition. The question throws her, as though she's surprised anyone would ask for a reason a company like Bain would loot a firm like KB Toys. "It wasn't like, 'Yay, we did a good job, we get a dividend,'" she says with a laugh. "It was like, 'We can do this, so we will.' " At the time of the KB Toys deal, Romney was a Bain investor and owner, making him a mere beneficiary of the raping and pillaging, rather than its direct organizer. Moreover, KB's demise was hastened by a host of genuine market forces, including competition from video games and cellphones. But there's absolutely no way to look at what Bain did at KB and see anything but a cash grab – one that followed the business model laid out by Romney. Rather than cutting costs and tightening belts, Bain added $300 million in debt to the firm's bottom line while taking out more than $120 million in cash – an outright looting that creditors later described in a lawsuit as "breaking open the piggy bank." What's more, Bain smoothed the deal in typical fashion by giving huge bonuses to the company's top managers as the firm headed toward bankruptcy. CEO Michael Glazer got an incredible $18.4 million, while CFO Robert Feldman received $4.8 million and senior VP Thomas Alfonsi took home $3.3 million. And what did Bain bring to the table in return for its massive, outsize payout? KB Toys had built a small empire by targeting middle-class buyers with value-priced products. It succeeded mainly because the firm's leaders had a great instinct for what they were making and selling. These were people who had been in the specialty toy business since 1922; collectively, they had millions of man-hours of knowledge about how the industry works and how toy customers behave. KB's president in the Eighties, the late Saul Rubenstein, used to carry around a giant computer printout of the company's inventory, and would fall asleep reading it on the weekends, the pages clasped to his chest. "He knew the name and number of all those toys," his widow, Shirley, says proudly. "He loved toys." Bain's experience in the toy industry, by contrast, was precisely bupkus. They didn't know a damn thing about the business they had taken over – and they never cared to learn. The firm's entire contribution was $18 million in cash and a huge mound of borrowed money that gave it the power to pull the levers. "The people who came in after – they were never toy people," says Shirley Rubenstein. To make matters worse, former employees say, Bain deluged them with requests for paperwork and reports, forcing them to worry more about the whims of their new bosses than the demands of their customers. "We took our eye off the ball," Patnode says. "And if you take your eye off the ball, you strike out." In the end, Bain never bothered to come up with a plan for how KB Toys could meet the 21st-century challenges of video games and cellphone gadgets that were the company's ostensible downfall. And that's where Romney's self-touted reputation as a turnaround specialist is a myth. In the Bain model, the actual turnaround isn't necessary. It's just a cover story. It's nice for the private equity firm if it happens, because it makes the acquired company more attractive for resale or an IPO. But it's mostly irrelevant to the success of the takeover model, where huge cash returns are extracted whether the captured firm thrives or not. "The thing about it is, nobody gets hurt," says Patnode. "Except the people who worked here."

2024-05-20T01:27:04.277712

https://example.com/article/9982

Community Outreach Monarch has partnered with numerous organizations to provide unique opportunities for our students and the autism community. The Children’s Museum of Cleveland In 2017, Monarch Center for Autism’s Welcoming Spaces Program developed a partnership with The Children’s Museum of Cleveland to develop customized visual, social, communicative, sensory, and behavioral supports. These supports are located throughout the museum – from the ticket desk toolkits and call-ahead accommodations, to the sensory friendly room, social narratives, visual schedules, visual/sensory maps, video models, and more. The supports are intended to prepare visitors with autism and other special needs before, during and after their visits, so they leave feeling happy, successful, and eager to return. The Cleveland Cavaliers Since 2014, Monarch Center for Autism’s students, families and staff have participated in numerous programs at Quicken Loans Arena including Autism Awareness Night games with the CAVS, center court recognition ceremonies, and a CAVS national championship celebratory letter campaign. Most recently, Monarch’s High School students were afforded the opportunity to take backstage tours of Quicken Loans Arena. They visited the main office, private lounges, a weight room, non-player locker rooms, the penthouse suite, the VIP club, and the basketball court, where they took pictures. The tours were incredibly exciting for all involved! edWeb Since 2015, Monarch Center for Autism has been a member of the consortium that sponsors edWeb’s Teaching Students with Autism community, a free professional learning community (PLC) where educators can share information to help support the needs of students with autism. This community provides a forum where educators can participate in conversations on best practices and technologies, hear from experts, and learn about the latest research on autism spectrum disorder (ASD). The community hosts free webinars that offer CE certificates for educators, live chats, online discussions, and a resource library. For more information and to register, please visit https://www.edweb.net/autism. NEOEA Day Since 2010, Monarch Center for Autism has offered free lectures to members of the autism community on a variety of topics including Behavior, Visual Supports, Technology, Mental Health, Transition Services, and more. Since 2015, we have partnered with North Eastern Ohio Education Association (NEOEA) to host annual conferences on NEOEA Day for educators who are members of local OEA and NEA associations throughout northeastern Ohio. Spring Fling Since 2013, Monarch School has hosted an annual “Spring Fling” dance for Monarch students ages 13 and older and Monarch Alumni. This is a unique and incredibly exciting opportunity for the students, alumni, families and staff who participate. Special accommodations are made to meet participants’ needs including softer lighting, quieter music, a sensory lounge (for overstimulation breaks), distinct dietary options, visual supports, and typical peer models. Parents/caregivers accompany students to the dance and remain on the premises throughout the duration of the dance. A dance committee, comprised of Monarch students, staff and parents, plans the event. It is modeled after a typical prom-like experience, which many of our families never thought possible for their children. ETON Since 2014, Monarch Center for Autism has partnered with ETON Chagrin Boulevard to launch the annual Snowflake Giving Garden project. Throughout the holiday seasons, artwork made by students from Monarch hangs inside the mall. In preparation, Monarch students spend five weeks working one-on-one or in small groups with Monarch’s Art Therapists and staff to create art inspired by the winter season. Students use a wide variety of techniques and mediums to create their artwork. The project is a therapeutic exercise that affords Monarch students the opportunity to express themselves visually. The final collection of artwork showcases the talents and creativity of Monarch’s students and highlights the tremendous capabilities of individuals on the Autism Spectrum. The Musical Theater Project Since 2015, Monarch School has been selected to participate in a 4-week artist-in-residency theater program entitled “Kids Love Musicals!” run by a Cleveland-based arts education non-profit called The Musical Theater Project (TMTP). The program’s curriculum and structure were specially adapted for students with Autism. Each year, teaching artists from TMTP came to Monarch twice a week to work in 30-minute increments with small groups of students and staff. They presented selected scenes and songs from a musical (i.e., The Wizard of Oz, The Jungle Book) and involved class members in improvisation, performance and discussion of scenes and songs. The residency afforded students opportunities to explore musical theater (song, movement, acting) while focusing on community, teamwork, self-awareness, self-confidence and problem-solving. Artists Archives of the Western Reserve In 2013, Monarch Center for Autism partnered with The Artists Archives of the Western Reserve to co-launch an art exhibit entitled “Art Interprets Autism.” It featured interpretations and/or collaborations of artwork created by 18 Archived Artists and 18 Monarch School students, in a variety of medium. The show ran for a month at a gallery in Cleveland, and was accompanied by a speakers’ symposium on topics related to autism and art. Van Fundraiser Throughout the 2016-2017 school year, Monarch Center for Autism hosted a van fundraiser. Thanks to 96 donors throughout the community, Monarch raised more than $32,500 with which we purchased a brand NEW Toyota Sienna van! Monarch students and staff now enjoy longer and more frequent outings into the community in our very own vehicle. Airport and Transportation Security Administration In 2011, Monarch Center for Autism initiated a relationship at Akron-Canton Airport with the Transportation Security Administration (TSA) and Continental Airlines (now United Airlines) to educate security and airline personnel about Autism Spectrum Disorder. The goal was to train airport personnel to understand the social and communication deficits frequently demonstrated by individuals with Autism Spectrum Disorders, so they could more effectively promote positive travel experiences for these individuals. In 2012, Monarch staff returned to Akron-Canton Airport to train additional TSA officials about autism. This training included the implementation of visual supports at the security checkpoints to facilitate travel. In June 2012, twelve Monarch School students visited Cleveland Hopkins airport and engaged in a simulated United Airlines trip, which afforded airport personnel hands-on-training.

2024-01-25T01:27:04.277712

https://example.com/article/5659

Q: Evaluating time series clustering through EM/GMM I perform clustering of time series into k=[2,N] number of clusters by using either DTW+kmedoids or DTW+single linkage+hierarchical clustering (HC), as advised in a previous post: Dynamic Time Warping Clustering Regarding the evaluation of optimum number of clusters, I want to use expectation–maximization (EM) Gaussian Mixture Models (GMM) and determine the k that maximizes the log-likelihood for each approach. My questions are: What should be the input dataset in EM/GMM? The DTW similarity distance or the raw dataset? Can the initializations in EM/GMM be the clusters centers of either the kmedoids or randomly selected seeds from the HC clusters? Should I run k-fold cross-validation of the input dataset with the EM/GMM and return the average log-likelihood value? A: Gaussian Mixture Modeling assumes ypur input data are coordinates in $R^d$ and contain Gaussian-shaped clusters. I don't think you can use this on time series. Also, GMM is a clustering approach on its own, and I don't see how you could use that to evaluate other clusterings.

2024-06-26T01:27:04.277712

https://example.com/article/9404

import * as vscode from "vscode"; import { ICommandParameter } from "../base/ICommandParameter"; import { CommandParameterCompiler } from "../base/CommandParameterCompiler"; export class ConfirmCommandParameter implements ICommandParameter { private value: string; constructor(private readonly message: string) { } public get shouldAskUser(): boolean { return true; } public async setArguments(state: CommandParameterCompiler): Promise<void> { let option = await vscode.window.showWarningMessage(this.message, 'Yes', 'No'); if (option !== null && option !== undefined && option == 'Yes') { state.next(); } state.cancel(); } public getArguments(): string[] { return [ ]; } }

2024-02-27T01:27:04.277712

https://example.com/article/7551

1. Field of the Invention This invention relates to an electroless copper plating solution having improved stability characterized by the addition of a stabilizer comprising a source of gallium alone or in combination with an additional stabilizer. 2. Description of the Prior Art Electroless metal deposition refers to the chemical plating of a metal over an active surface by chemical reduction in the absence of an external electric current. Processes and compositions useful therefor are known, are in substantial commercial use, and are described in numerous publications, including U.S. Pat. Nos. 2,938,805; 3,011,920; and 3,383,224 included herein by reference. Known electroless copper deposition solutions generally comprise four major ingredients dissolved in solvent, usually water. They are (1) a source of the copper ions, (2) a reducing agent such as formaldehyde, (3) an acid or hydroxide pH adjuster to provide required pH, and (4) a complexing agent for copper ions sufficient to prevent their precipitation in solution. In addition to the aforesaid major components of an electroless copper solution, it is known that other additives are needed for a commercially useful formulation, for example, to stabilize the solution and improve deposit properties. As to stabilizing the solution, it is known that certain additives added to an electroless copper solution in properly controlled trace quantities act as stabilizers and retard the rate of bath decomposition. Generally, these additives, or stabilizers as they are referred to in the art, are catalytic poisons. The concentration of the stabilizer in solution is usually critical. Trace quantities, typically in the range of a few parts per million, provide stability. An excess of stabilizer may partially or totally stop deposition of the electroless copper.

2024-02-22T01:27:04.277712

https://example.com/article/5000

Well, the faux-filibuster that Senate conservatives attempted wasn't enough to stop cloture, but at least we proved a point, right? Wrong. Still, you can expect that supporters of the "Defund ObamaCare" crusade will likely attempt to spin this as some sort of a moral victory. If anything good happens down the road, they will argue this laid the groundwork for that by "starting the conversation" with the American public about how bad ObamaCare is. I'm not buying it. Here are five reasons why conservatives are worse off for having fought this battle: 1. Conservatives are more divided as a result. In an era when Republicans have too often been split, opposition to ObamaCare should have been a unifying cause with broad conservative consensus. Instead, conservatives managed to invent a way of making ObamaCare into a divisive issue on the Right. This is a truly remarkable feat. It is like frat brothers fighting over whether or not Giselle is hot. What is more, those who opposed the move based on strategic (not philosophical) grounds were labeled part of the "surrender caucus," and compared to Nazi appeasers. It's gotten so bad that on Thursday morning, Sen. Tom Coburn told MSNBC, "I'm now no longer a conservative according to the standards that have been set by the expectations of this process." 2. There were better, more popular alternatives. Pushing for ObamaCare's implementation to be postponed a year would have been a much easier sell. After all, big business already benefits from the employer mandate having been delayed. Why shouldn't lunch pail workers get the same deal? Obama has already opened the door to delays. In fact, just this week, it was reported that he would "delay online ObamaCare enrollment for small businesses in federally operated health-care exchanges until November 1." As Steve Forbes writes, "A postponement would be immensely popular and would be a huge setback to ObamaCare." Another more populist approach would have involved forcing elected officials like the president and members of Congress, plus congressional staff, to sign up for ObamaCare and forgo a special exemption that subsidizes their premium payments. Conservative opinion leaders like Charles Krauthammer and David Freddoso have argued this would have been a wiser hill to die on. (This would have allowed Republicans to essentially say that Washington elites must play by the same rules as the American people.) Aside from picking a battle that might win public support, different positioning might have split the Democratic caucus, putting pressure on vulnerable red state Democrats to take a tough vote. Would Mark Begich and Mark Pryor really want to go on the record with a vote giving D.C. elites special taxpayer-subsidized health-care support? It's easy to see why conservatives rejected these ideas. They would have caused turmoil and chaos among Democrats. No, it's much better to create division amongst conservatives. 3. It changed the subject from Obama's failings. Think of where we were a week or so ago. President Obama had allowed Syria to cross the red line. His efforts to get congressional approval for intervention had crumbled. Enter Vladimir Putin, who outmaneuvered the president, making him look incredibly weak. But sensing their opponent was in the process of committing suicide, Republicans chose to interfere. The same thing happened after Benghazi when Mitt Romney interrupted the narrative. See the trend? When left to his own devices, President Obama looks small. It is only when he is judged in comparison to Republicans that he appears, in contrast, to be competent and capable. 4. It misled the base. Lying to your supporters is never a good idea. Neither is setting expectations, raising hopes, and then failing to deliver (sort of like saying, "If you cross this red line…"). Unfortunately, the defund idea was always premised on convincing supporters to do something that almost everyone who is knowledgeable and intellectually honest knew was impossible. Some supporters have even posited a Machiavellian rationale: ObamaCare needs to be defeated, but to do so, we have to build lists of supporters. And the only way to build lists of supporters is to manufacture exciting events to get people fired up. Why does this matter? Presumably, you can only cry "wolf" so many times, and the conservative movement will eventually pay a price for misleading the conservative base. 5. It reinforces the negative stereotypes people have about Republicans. Republicans have an image problem, and this reinforces at least two of the worst stereotypes. First, it's a reminder of the recalcitrant "party of 'no.'" It says that, by asking for ridiculous concessions, Republicans aren't interested in governing, but instead, in gridlock. Additionally, this plays into the "war on science" meme. Just as Republican poll "truthers" were shocked — SHOCKED! — to learn that Mitt Romney didn't win by a landslide, they may be equally stunned to discover that — having lost two presidential elections and a Supreme Court decision — they don't have enough votes to stop ObamaCare. The good news, of course, is that a handful of senators and conservative groups made a lot of money and garnered a lot of press. So I guess that's something.

2024-06-13T01:27:04.277712

https://example.com/article/7550

Daily Encouragement May 24 President Toda said: "Those who do not value the organization are practicing self-centered faith. With such faith you cannot expect to receive the truly profound benefits of this practice." Working hard within the organization for people's happiness and welfare is itself a truly noble Buddhist practice.

2024-03-08T01:27:04.277712

https://example.com/article/3097

Q: Python: most effective way of filtering a list I hope I'm not duplicating here :-) I'm wondering what's the most effective way of filtering a python list. The task I have in hand is to find out list elements that are not appearing in some other list. My fist list is a list of objects (without unnecessary details): Class A: def __init__(self,item1, item2): self.item1 = item1 self.item2 = item2 later on, in my script I'm parsing a input text file and populating a list1 with real data (both item1 and item2 fields are strings) there's also a second list, list2 containing just a list of strings coresponding to item1. What I'm interested in, are the elements in list1 where item1 is not in the list2. (list1 contains roughly 3000 elements, list2 is bigger - circa 60000 elements. ) my fist attempt is quite obvious: notMatched = list(itertools.ifilter(lambda x: x.item1 not in list2), list1)) now, it works as expected, giving me exactly what I want, but I'm still wondering if it's the best solution I could came with. Any idea anyone? Thanks A: Make list2 a set. This will improve the performance of the lookup not in list2. You can probably get away with this: set2 = set(list2) not_matched = [a for a in list1 if not a.item1 in set2]

2024-02-18T01:27:04.277712

https://example.com/article/1614

Q: Edit the text selected in JtextPane I have two Jtextpane what i want to do is that i what to select the text from 1 Jtextpane and i want that it should appear in the second Jtextpane after a menu item Edit is selected which i have done popMenu[i].addActionListener(new ActionListener() { @Override public void actionPerformed(ActionEvent e) { String str = e.getActionCommand(); ..... if (str.equalsIgnoreCase("edit")) { taSecond.setBackground(new Color(0xFBFCDD)); taSecond.setText(taFirst.getSelectedText()); System.out.println("bounds====>"+taFirst.getBounds()); taFirst.getBounds().setBounds(taFirst.getBounds()); editedText = true; } } }); Now I am clueless that how would i put the edited text back to the selcted position from where i got the text can anyone tell the solution A: Thank you try { doc.remove(start, end-start); doc.insertString(start, str, normal); editedText=false; } catch (BadLocationException ex) { Logger.getLogger(ChatPane.class.getName()).log(Level.SEVERE, null, ex); }

2023-12-15T01:27:04.277712

https://example.com/article/4608

AuraSunDial Did you ever want to synchronize the ingame time to the real time? Then this plugin is for you! It’s super simple. No config required, just drop it in your mods folder and it works. Commands /realtime: Usage: /realtime <enable|disable> [<world>*|all] Aliases: /realtime, /rt, /sundial, /sd Permission: sundial.command.realtime.<enable|disable>.<world> Permissions sundial.command.realtime.<enable|disable>.<world> Planned Features Maybe allow setting a time offset. Command to enable and disable it. Suggestions and Bugs So if you have feedback on my planned features, suggestions on what I can add or improve or what additional data I could synchronmnize, tell me! Also please report any bugs you encounter, so I can fix them. (Click the Issues link up at the top.) You can also get quick support on our Discord! Support If you want to support the Aura Development Team, which I am part of, you can support us on Patreon!

2023-08-15T01:27:04.277712

https://example.com/article/4851

Site Handling & Storage More InfoLess Info Site Mobile Handling and Storage Mobile Trolleys, Mobile Incident Storage and Storage for civil industrial site use including the Armorgard LoadAll Plasterboard folding and stacking trolleys for the safe handling and movement of up to 1 tonne boards. Also the Rubble Truck for site material waste handling, BarroBox secure mobile tool storage - move it around just like a wheelbarrow!

2024-07-27T01:27:04.277712

https://example.com/article/3699

“Judging from the residual scarring and yesterday’s blood tests…” he said, noting something down on his clipboard, “I think next week the bandages can come off for good.” For six months I came to this office every afternoon and had the bandages changed. That was over 180 times. What were seven more days? I simply nodded in response. “And I’ll set up an appointment for the week after that, for the eye people to come in. They’ll take molds, pictures, and all that. You’ll look good as new!” I didn’t want some glass eye. I didn’t want to look lazy-eyed or crazy. I’d seen people with false eyes before. It was uncanny-valley type stuff. I wanted my eye. My real fucking eye. But that ship had sailed a long time ago. “…Okay,” was all I could get out of my mouth. My bandages were changed and I had been given my medications. The nurse kept them here, a precaution against ‘the black market.’ Apparently my drugs were in high demand among the more scurrilous of the academy. But I was free to go now. It didn’t stop the nurse from lecturing, like he always did. “You know Koji, you’re basically back to full strength. Why don’t you get out there? Join a club or something, it’d do you a lot of good. My spies tell me they never see you around.” Ah yes, the nurse, legendary spymaster. Though most of his spies were athletes and I didn’t hang out around the track or fields very often. Just Tuesdays, when- The nurse grabbed me by the shoulder as I was edging my way out the door, interrupting my train of thought. “Listen kid, I know you’ve gone through a lot. But so has everyone else here, you know that. Despite what happened to you don’t think they’ll judge you for it. Here we’re all just people.” “Y-yeah, okay.” “I’ll get you out there one day Koji. Trust me on that. I have my ways.” This frightened me more than anything. Did he now have people following me? Did they know about me, at least more than the others did? I scurried out the door and quickly ran across campus to my dorm. Locking the door, I sighed in relief and turned on the lights. I had blocked up my window. Too much sun. Too many people outside. It was more like my room back home this way. More like nothing had changed. I went over to my computer. Students weren’t supposed to have computers but my parents persuaded the administration. “We’re so far away,” they said, “it’s the only way we can keep in touch.” My mom called me on Skype twice a day. I never turned on the camera. I didn’t want her to look at me, it would just remind her of my failure. But we talked. Some days it was the only person I talked to, at least with my mouth. Deaddrop1911: <if it isn’t crippled kawamori!> My computer. Someone was messaging me. VariableValkyrie: <I told you to stop calling me that.> Deaddrop1911: <but isn’t even more alliterative in your native japanese? Deaddrop1911: <katawa kawamori or something?> VariableValkyrie: <Yeah, that’s about it.> Deaddrop1911: <so what’s up koji?> Deaddrop1911: <holding things down on your end?> VariableValkyrie: <I’m fine.> Deaddrop1911: <aight then> Deaddrop1911: <i went to a rifle range over the weekend> Deaddrop1911: <the coolest thing i’ve ever done> VariableValkyrie: <Congratulations Jake. I know you’ve always wanted to do that. Fun?> Deaddrop1911: <fuck yeah it was> Deaddrop1911: <you gotta reach for your dreams, bro> Deaddrop1911: <its a lot easier than you think> Deaddrop1911: <that girl you always dream about> Deaddrop1911: <the german? germans are freaks by the way> Deaddrop1911: <talk to her today. or tomorrow, for you i guess> VariableValkyrie: <You know I can’t do that.> Deaddrop1911: <fuck what you cant do> Deaddrop1911: <life is about fucking what you cant do and doing it anyway> Deaddrop1911: <you think they were gonna let me anywhere near a range after what happened to me?> Deaddrop1911: <but i got there, and it was great> Deaddrop1911: <fuck reason and catch your dreams> Deaddrop1911: <i gotta get to class bro, i’ll catch you around> Variable Valkyrie: <Okay, see you later.> Most of the time was spent as it had been at home, on my computer playing video games and surfing the internet. Sometimes it even felt like nothing had changed. If only I were so lucky. * * * Class. The worst part of my day. Not that I didn’t like learning, I just knew the other students were afraid of me. Or at least it felt like that. Class 3-2 was for the visually impaired. I mean, I guess I technically was, with one eye, but it was mostly blind kids and other much more severely impaired than I. So I sat in the back. I could see from back there and it also let others who couldn’t sit ahead of me. It also kept me away from everyone else, lest they accidentally touch me. The repercussions of which scared me half to death. I didn’t want to put anyone else through what had happened to me. But 3-2’s instructor/homeroom teacher, Ms. Ito (who was also blind), focused on History. I liked History, it was like living vicariously through other people. Getting to do things I knew I’d never be able to do. Though I wished I could stay in that class all day, I had a full schedule. Something about making up for lost time. They also put my in a sign language class. When I asked why, the guidance counselor simply said “Because you have two hands.” At first I thought it was some stupid joke but after my first day at Yamaku I saw why. And I guess they needed all the translators they could. Helped to integrate the deaf students into the school’s social circles. Not that I’d ever be much good at that. Today was Tuesday though. Best day of the week. After class, I took the long route back to the dorms, past the soccer field. I suddenly felt scared. I wondered if the Nurse’s spies were watch. No matter, I brushed it off. Women’s soccer had matches on Tuesdays at home, Thursdays were matches away. I had looked up the schedule on the school’s website, though the schedule was probably for parents. Students were supposed to ask. Walking by the field, a crowd had already taken seats in the stands. I never sat down but I thought it looked reasonable to stand and watch for a little while. Like, “Oh, I’m just on my way home but then I happened to see this soccer match and thought I’d just watch for a little bit.” Like anyone’d believe that though, two months in a row. But I couldn’t stop now. If people had seen me and I stopped, then they’d think I had been planning something. If I sat down, that’d be weird too. Why hadn’t I done it after the first week? The situation was too complex now. Stopping, I looked for her golden hair blitzing across the field. Jessica Frederson, captain of the Girl’s Soccer team. And daughter of the former German Ambassador, I found out thanks to some internet research. I knew why she was here though. A news article from three years ago revealed her and her family had been in a car accident, a really bad one. On the way home from a diplomatic dinner, their car had been hit side-on by a speeding driver running a red light. Her father was restricted to a wheelchair, his spine snapped. Jessica had lost her left arm at the elbow, mangled in the metal. She’d also needed a new kidney and liver, which had failed after internal bleeding. Her mother, at the wheel that night, died. Apparently Jessica had made a remarkable recovery, as donor organs were found quickly. Her father had retired from politics after that, and also to the Japanese coast. His wife was buried here, so apparently that was reason enough to stay. Jessica had lived here her entire life as well, so I guess it made sense for her to stay. She was beautiful, the most beautiful girl I’d ever seen. 165 cm tall, thin and with close-cropped blonde hair. A sporty look, I guess. But her best feature was her eyes. Steely blue with determination, I caught glances of them on the field, vicious and sharp and ready for battle. I’d also seen them up close once. I accidentally bumped into her, the first day I was at Yamaku. Off the pitch, her eyes were kind and colored like a warm summer sky. “I’m terribly sorry,” she had said. “N-no… it’s my fault. I should… should’ve been paying more attention.” “Your loss then, it’s a great advantage for me to be in your debt,” she smiled ear to ear, “Jessica Frederson, 3-3.” “Kawamori. 3…, 3-2.” “Well Mister Kawamori, do you have a first name?” “K-Koji.” “Well Koji, where I’m from we call friends by their first names.” The bell rang. “Shit, I gotta get to class. See you around, Koji!” “B-…Bye!” I turned and wove as she tore down the hallway. Bearing in mind the fact that she was born and raised in Japan, the gesture was still nice. I greatly appreciated it. She was the first at Yamaku, though not knowing of my condition, who’d been genuinely friendly to me. Everyone in my class had been debriefed on my condition. It was protocol, with something as potentially dangerous as MRSA. Jessica hadn’t known – she couldn’t know – and had thus been friendly to me. I could never tell her, and could never speak to her. I didn’t want her getting hurt. I knew, she being immuno-compromised from the transplants, was at more a risk than anyone else. If she caught what I’d had… she’d die. Fuck, that was the reason I’d got it in the first place. It’s one thing to go through… all that… and then find out you caught the killer bug, MRSA, and could die anyway? I’d almost offed myself then. The added pain was unbearable. I didn’t want anyone to go through that. Especially not her. So I watched her. I tried not to be creepy about it, but there was no other way. I couldn’t talk to her, talk to anyone. I was there, watching the game, that Tuesday. The coach called a time out. Jessica called out for a towel and deftly wiped the sweat off herself, a combination of overcompensating with her right arm and calculated placement of the remains of her left. Grabbed a bottle of water and practically downed it in one gulp. She talked with her teammates, probably discussing plays, then ran back onto the field. At the last second, she turned around and looked, looked directly at me. I turned away as quickly as possible. She saw me. Had I been staring? Had she felt my eye on her? Was I leering? Oh God I didn’t want to be leering. I was a creep now, a stalker. She saw me, she knew. I practically ran back to the dorms. * * * VariableValkyrie: <Jake, are you there?> Deaddrop1911: <always around somewhere buddy> Deaddrop1911: <was in the middle of a match but whenever you start with “are you there” its gotta be more importatn> VariableValkyrie: <It’s just stupid League of Legends anyway, it’s destroying your brain.> Deaddrop1911: <so you admit i have a brain to destory> VariableValkyrie: <Not if you keep up the misspellings. How am I better than you at typing your native language?> Deaddrop1911: <whatever bro> Deaddrop1911: <whats up?> VariableValkyrie: <She saw me today. At the soccer field.> VariableValkyrie: <I’m a creeper now, aren’t I? That’s what Americans call it these days, right?> Deaddrop1911: <i think you’re overreacting> Deaddrop1911: <besides how does she know you were watching her?> Deaddrop1911: <you were just there to supports the team is all> VariableValkyrie: <The school outcast suddenly has spirit? I don’t think so man.> Deaddrop1911: <whatever, bro> Deaddrop1911: <did you talk to her? explain yourself?> VariableValkyrie: <No.> VariableValkyrie: <One day. The bandages come off next week, or so they say.> Deaddrop1911: <that’s good> Deaddrop1911: <from what the internet tells me youre fine from here on out. not contagious at all.> VariableValkyrie: <I’ll believe it when I see it.> There was a knock on the door. The clock on the computer said it was 7:48, but time didn’t really matter to me. My bandages were changed and my homework done. I was free to delve into cyberspace as wished. Why would the nurse be bothering me? He was the only one who came around, usually when I forgot to come in to him or when I refused to. I went over to the door, picking up a loose paper, placing it in the appropriate bin and opened it. I hooked in the little door chain I had illegally installed on the door and opened up. I had wanted to get a stronger-security bar but I feared that might be too obvious and I’d get written up. “Hey there Koji.” It wasn’t the nurse. It was Jessica. Oh shit, oh shit. She saw me staring, she must have. She’s here to confront me, to report me. I’m fucked. They’ll take my computer away, as punishment. What do I do? What the fuck do I do? “…Hi.” “Can I come in?” The prettiest girl in school, come to my room, and wants to come in? This has to be a set-up. “I… I mean y-you… you d-don’t know about… me. I’m – I’m dangerous. To you. To… everyone.” “You mean the MRSA?” She said it like ‘mursuh,’ not spelled out as I’d usually heard. She knew. How did she know? She knew that I was a walking time bomb and could kill her at any moment. My face must have shown nothing but shock or horror, because she continued: “You’re wondering how I know. Nurse told me. He also said that you’re pretty much healthy now. The antibiotics killed most of it or something and now the risk factor is pretty much zilch. Now are you gonna let me in or not?” I nodded nervously, closed the door, removed the chain and opened the door. The first time someone’s coming in to my inner sanctum. It’s probably because it is her that I’m opening the door. Anyone else and I might have shut the door and deadbolted it, but the one person who’s shown me genuine kindness… Still there may be something to this. Can’t let my guard down. “Wow, this is a cleaaan,” she said walking my room, “my room’s a positive dump compared to this.” “Y-yeah, they said at the hospital I should be… cleaner.” Clean was an understatement. I was proud of how clean my room was. One dresser, one desk, one bed and one closet. Two pairs of shoes, two uniform jackets and two uniform shirts hung neatly in the closet. Two pairs of everything else neatly in the dresser, on top of which were various sorting bins for papers and assorted things. My bed was made; you could bounce a coin off the taught sheets. Desk had the monitor, mouse and keyboard, all wires properly hidden away underneath the desk and stapled to the wall to prevent them from getting caught and tangled. “Oh man you have a computer? That is so cool! How’d you manage to get away with that?” “My parents… I’m from K-Kagoshima so it’s hard for them to come visit…” “I see, I see. Con man are we?” She winked. Winking? At me? This was too strange. “Do you play video games? I mean, with a computer like that you have to!” She continued, barely noticing my confusion. “I used to play a lot before, well, I think you can guess.” She held up her stump. “Y-yeah, I can see how that’d make… things hard… I’m sorry, I don’t want – I didn’t mean – It’s just –“ “It’s fine, really. I’m used to it by now. Besides, I play soccer now. Not the same as fighting aliens or solving crimes or getting in a war but it’s an adrenaline rush all the same! Say, do you have any new games? Like from this year?” A girl. No. The girl. In my room. Asking about my video games. This is like some sick dream, it has to be. “L-like… from this year new?” “Yeah, you know, newer than from before my accident. Without computers here at school I have to read about new games from magazines from the convenience store. Do you know how antiquated that feels? My dad can access his entire movie library from his cell phone but I have to read about video games in a magazine!” “Uh, s-sure then…” I went over to the computer. Opened the games directory. Deaddrop1911: <dude?> Deaddrop1911: <duuuuuude?> Deaddrop1911: <im calling your mom if you dont answer.> Deaddrop1911: <im serious bro> Shit. Jake. VariableValkyrie: <I’ve got to go, I’ll be back later.> I signed off as quickly as humanly possible. “Who was that?” She was watching. “J-Just… a friend.” She shrugged it off. “Wow, this thing is fast. I mean, I must be out of the technological loop, it’s been about four years since I last used a computer, but this is fast. Wait, is that Portal 2? The first came out right after I got out of the hospital? This one is brand new! Can we – er, you, play it?” I booted up the game. I guess Jessica likes Western games, too. Though that makes sense. And for a second I was relaxed, merely thinking about playing games with this girl before I realized, it was this girl. Jessica Frederson, star of the soccer team. “Stop being nervous and play the game, dude. I only have like 30 minutes before I haveta get going and do my homework.” And so I played the game, trying my hardest to pretend that there wasn’t someone watching at all times. While she was also having visceral reactions to the game. Her eyes darted across the screen, eating up every moment. Some time passed, then: “Hey Koji, what time is it? I don’t wear a watch because… well you know.” “Uh…” I checked my watch. “E-Eight fifty… two,” as the second hand passed 12. “Shitshitshit, I’m not gonna have enough time to do my homework. I gotta run, dude. But I did come here to talk to you for a reason, don’t forget that. I’ll find you at lunch tomorrow, we’ll talk then.” “B-bye,” I called after her golden whoosh. A whole hour spent with Jessica. It was like a dream come true… but I dream I didn’t want to have. Every time I thought about her, her giggling and smiling, I thought about the potential harm. I mean the nurse did say I was better, but they said that when I was 8, too. And look what happened then. And she said she was going to find me? She must really be one of the nurse’s spies. Did the nurse know where I ate lunch? It was a private spot. Really private. Not something cliché like the roof either. I suddenly dreaded tomorrow. * * * I liked Sign Language class well enough. I could sit in the back and watch other people translate. I practiced sometimes in the mirror in the bathroom but like usual I was content to watch. There was someone new in the room today though. A young woman, perhaps just 21 or 22, with long brown hair. She was dressed in a plain skirt and professional shirt, looking the part of a sophisticated college student. The instructor said, signing along the whole time: “This is our new Teaching assistant, Shiina Mikado. She’s working with us while she studies to become a sign language teacher.” “Please, call me Misha! I’m not a teacher yet! Wahaha~” I didn’t know the sign for her curious laugh but the motions she made seemed to nail it. “Anyway, I graduated from Yamaku not too long ago-“ She was interrupted by one of the, let’s say, more brutish students in the middle of the classroom. “What’s your disability?” The teacher shot him a dirty look but Mikado took it in stride. “Well, I’d rather not get into that now. But I learned sign language like you guys did, in this very classroom! So I’m so very glad to be working here now! Wahaha~” And so Mikado lead today’s lesson, seeming to know exactly where the instructor left off. She’s good, I thought. She signs like it’s second nature. Her energy and friendliness suit her choice of teaching too. The bell rings after a while and I try to silently slink out as usual. “Ah, Kawamori, is it?” Mikado calls across the room to me. Instantly all the eyes in the classroom turn on me. Shit shit shit. I’m sweating bullets. “Just wait around for a moment? I’d like to speak with you.” The class takes this as their cue to stop staring and continue out the door. After they’ve left, Mikado comes running, no, bouncing over to me. “Koji, Koji Kawamori?” “Y-yes?” She extends her hand. “Pleased to meet you. And please, call me Misha! Wahaha~, I’m really not a teacher yet.” I limply return the handshake. There are no bandages on my lower arm but the ones on my face are painfully obvious. “Your instructor here says you don’t have a partner to practice with. Why’s that?” “I… I don’t… the other students wouldn’t want to practice with me.” “That’s silly~ They have to practice with you, it’s part of the experience in school life! Meeting others, forming social bonds, all that stuff!” I just nod. What is she getting at? “Anyway, Koji – can I call you Koji? I’ll call you Koji – I’m extending you a one time offer totally not refusable one time deal here! One on one practice sessions with me, after the day’s classes are over.” “But… I-“ “Nonsense! Wahaha~ We’ll meet in the room, it’s usually empty after class. If it isn’t we’ll go to the roof or something like that. Anyway, get to your next class, kid. You’re going to be late!” I bow and run off. This is… this is scary. And unprecedented. I thought you were allowed to do things at your own pace here? Well I guess if she’s from Yamaku, she understands. But I still feel rushed. And frustrated. This is too much for me to handle right now. I look at my watch. Lunch in two periods. Shit. * * * The alley between the gymnasium and the school was rarely, if ever used. At one point the two buildings were completely separate but at some point they built a tunnel connecting the two, leaving two alleys on either side. The one more facing the school grounds was a common hangout, a nice bit of shade. The other side, facing the fence, was my side. When it was nice out, which I discovered when I first came to the school, it was secluded and quiet but still outside. Now that it was spring I had started coming back out. The gardeners had still not trimmed it up from the winter so it was a bit overgrown. But it was still my side, I was comfortable there. I unpacked my lunch from my bag. Once a week, Sunday nights, I went down to town to get supplies. Seven boxed lunches, enough ramen for dinners and a box of cereal for breakfast. But as far as I could tell, I hadn’t been followed. Maybe Jessica forgot. Hopefully she forgot. Then, halfway through my lunch, I saw her walking around the corner of the gym. “Hey Koji! This place is hard to find.” That is why I ate there. “H-how did you find me? …I didn’t see a-anyone follow me.” She pulled out a small cell phone. “Emails! I just made use of the spy network to find out where you were going. Wonders of technology, these things.” Cheeky. But my suspicions were confirmed. The nurse was watching me… somehow. I didn’t like that feeling of that. “Whatcha got for lunch, dude?” “J-just a boxed meal… from the store.” “Laaaame. Here, have some of my spargel. I made it myself! It’s not in season, but even fresh asparagus is hard to get in Japan so I make due.” I glanced at the little plastic box she had opened while she sat down across from me in the alley. Little white stalks of vegetable stared back at me. It wasn’t really like anything I’d seen before. “It’s from back home. A national treasure. Come on, have one!” I grabbed a stalk with my chopsticks. It wasn’t bad. Tender and juicy. I was surprised, they looked at first like little white sticks. “Good, right? My… my mom taught me how to make it. Before, you know.” “I – I, uh…” I tried to change topics. “Is it… hard to cook… with just one hand?” “Hahaha, yeah it is! Nobody ever asks though, they’re too afraid of offending me or something. Luckily all you really have to do is steam the spargel and add sauce to the top. Pretty easy and fast, too.” “It’s pretty good… thank you f-for sharing.” “No problem. Oh! I’m supposed to talk to you about something.” She was clearly easily distracted, but she continued. “Why do you stop by the soccer matches once a week? The other ‘spies’ tell me you don’t go to any other events.” I glanced nervously to the side, completely unsure as to what to say. That I went there to catch a glimpse of her? That it was a highlight of my week? I mean, I barely knew the rules of soccer. You kicked the ball into the net and that’s about all I ever figured out. I just shrugged, hoping that’d be enough of a response. “Hmm. You don’t look like you play; I think your main hobby is video games. And I don’t think you’re interested in it because you like to watch sports. You don’t have any posters in your room or watch the games in the lounge with other kids… but you do have internet, so maybe you watch it there? …Nah. I’m going to guess… you’ve got a crush on someone on the team!” Horror. Shock. Blood drained from my face. If it was fully uncovered she’d see how pale – paler – I had just become. Pupils dilated. Mouth slightly agape. I just saw the face of infinity and it scared me. “That’s it! I knew it! Some of the girls, maybe your girl-“ She giggled, “might think it’s kind of creepy. Guy watching a girl week after week? I think it’s kind of sweet though. I mean, given your conditions and personality, it shows you really care! Enough to go out once a week and cheer her on, despite how much it hurts to be in public.” If only you knew, Jessica. If only you knew. She seemed lost in thought for a little bit. She at another piece of asparagus, mulling something over in her head. If I wasn’t so crippled with anxiety right now I’d be running for my life, just to be out of it. She finished the piece and spoke again. “That settles it then.” “W-what?” I’m totally beguiled. “I’m gonna be your wingman. I’ll help you get out there and confess to her, tell you what to say and all that. You know, win her heart!” The situation went from bad to worse at that moment. 100 to 200 km/h. I’m almost certain I gulped, like in some bad cartoon. Thankfully, the bell rang. “Aw man, I didn’t even get to finish! Spent too much time looking for you.” She winked. “Anyway, I gotta jet. I’ve been late too many times for English already, teacher’ll kill me if I’m late again. See you later Koji, we’ll work on this together!” “S-see… you. See you later.” With a flash she was gone again, and I sat there completely confused. What would I do? What would happen when she found out it was her? She was going to make me talk to people? She was going to spend time with me? She’d get sick. I’d get people sick. What about when she finds out I have no friends at all? She’d reject me, even before she finds out I… I like her. In that way. I hung my head. This was going to be bad. * * * “Koji! I’m glad you came! Wahaha~” I was standing outside the sign language classroom. Mikado was there. Apparently there was a club meeting after classes. I guess we’d be going somewhere else. “Y-you... made me.” “True enough! I may not be a teacher but I can still make you students do things!” Frightening. Unchecked power in her hands would give me nightmares. “So let’s get started! Basic conversation, see what you know and all that! [Good afternoon, Koji!]” I raised my hands in front of me and fumbled to put words together. I really hadn’t practiced as much as I liked to have thought I did. “[Good… evening. No… I sorry… good… afternoon, Mr…. No, no, no, Mrs-]” Embarrassment all over my face. “Wahaha~ [No need for formalities! Misha, please!]” “[Good… afternoon… Misha.]” “[How are you today?]” “[I… good-]” “[I’m.]” “[I’m… fine.]” “[Glad to see that. Tell me something about you, Koji.]” “[I… play… games. On computer. I’m… not… social.]” Was I really telling her that, here on the roof with my hands? I guess the disconnect between my head and my hands was greater than between my head and my mouth. It was easier, this way. Even if I didn’t have the words, she was watching my hands, not my bandaged face. “[Any friends here at school? Someone you get lunch with, maybe?]” She said it with a wink. She must have seen me at lunch, somehow. I mean, the alley was close to the teacher’s parking lot… Shit was this rumor going around the school? What would people think? The other students were really keen to spread rumors and gossip, I’d overheard a lot of things. In a day my entire life had changed. I wanted it to back to normal. I just wanted to go back to my dorm and fall asleep. This was a bad dream. Misha looked at me with some concern. I guess panic had set in again. “Touched a nerve there, did I? Hey kiddo, it’s fine, we don’t have to talk about it. Topic dropped.” Was it raining? It had to be raining all right. My cheek was all wet. With my eye also went the tear ducts. I had figured this out on multiple occasions. Crying from one eye, to self pity, is the saddest thing I’d ever experienced. “Hey, hey, calm down. I really didn’t mean to push. There, there,” she said patting my shoulder. She came in to embrace me for a hug. No no no, she can’t touch me. She’ll get sick. I can’t let her touch me. “N-no… No. Stop. Don't! DON’T TOUCH ME!” I pushed out of her arms and ran for the doorway. I didn’t stop until I got back to my dorm. Locked the bolt and the chain. Went over to my bed and cried. * * * I didn’t go to class the next day. I don’t remember if I ate, either. Didn’t leave my room at all. There was no need. I was done for. If I showed my face around school I’d be laughed out. Better to stay in here, flunk out and have my parents come pick me up. I didn’t answer my mother when she called me, either. I didn’t tell here about most things. She surely did not have to hear about this. For a few hours at night I was on my computer. Bullshitting with Jake. He really did have my mom’s skype address. If I worried him to much he would call her. So I didn’t say anything. How pathetic was that? Lying to someone I’d never really met? But mostly I just slept, wrapped in a blanket and darkness. I was safe here, in my cocoon. My thoughts drifted, to a better time. The last good time I can remember from before. The sky is a violent eruption of reds, oranges and yellows. The sun is setting and there are clouds painted red. Somewhere above a seagull cackles its maniacal laughter. The water is a deep blue, but calm. Katsuo and I are playing the water. He’s six, I think. I’m getting tired though, we’ve been at the beach all day. “Boys!” my mother calls to us. “We’re going to head out soon, come dry off.” There’s no one else left at the beach. The warm summer air stings the drying salt water on my face and smells like the glorious ocean. This is my quiet place, where I retreat to in my head when I need to relax and be free. After the first time the same beach was my private place, through middle school and then the first year of high school. At dusk it was quiet and beautiful. The warmth of the setting sun burned away all my problems. It’s so far away now. It’s been so long since I’ve been home. Since I’ve seen the sun set. I wish I were home. I wish I didn’t have to be at this stupid school, ostracized at a school for outcasts. I don’t mean that. They’re good people here at Yamaku. But they’re stigmatized and kept away from society. Even the townspeople manage to look at them and I strangely, every once in a while. Do cigarettes relieve stress? Maybe I should take up smoking. It’s not like my health can get worse. What was I going to do? I didn’t have enough food to last me forever. I’d have to leave to resupply. Maybe if I ran away? No, there was too much of my stuff here. I’d never be able to carry my computer around with me. And then there was my medication. I was tethered to someone else, no matter what. I hated this. So restricted, so needy. If people weren’t horrified by me they pitied me instead. Minutes turned to hours. I laid there in thought, contemplating the futility of my situation. I could stop taking the medications and let myself go. The pain of death would be a way out. Nobody would have to worry about me or my future. My grades had suffered because of the extended absences in the hospital. College was then ruled out. I couldn’t get a job because I had no skills. I couldn’t even join the military or work as a laborer because of my stupid fucking eye. Hikikomori or death. Not a hard choice. Sometimes I wish I were an otaku. At least then I’d have no shame. I could be blissfully unaware of myself, lost in some fantasy world or another. BANG BANG BANG. Someone was at the door. I checked my watch. 4:02 PM, Thursday. Only one person it could be, the Nurse. If I ever missed our regularly scheduled checkups and didn’t show the next day, he’d come find me. I felt my bandages. They didn’t feel wet, which was good. Maybe I wouldn’t get the berating I’ve gotten before, if the bandages were doing okay. They needed to be changed to get rid of the excess fluids and to let my wounds breathe for a few minutes. I took off my button-down uniform shirt, wrinkled by a day of laying in it. Usually I just wore a light t-shirt underneath but it was hot yesterday, so I didn’t have anything on at all. “J-Just a second!” I called out, peeling the first layers of my head bandages off. Might as well get this over with as fast as I could. My hair wasn’t long but it stuck to the bandages. They told me to let it grow, that way I could look “normal” when I finally was able to keep the cloth strips off my face. It was easy to get it off my face, impossible to get it on. My neck and shoulder were hard to reach too, but I didn’t want to be too much of a burden. I did the best that I could, so the Nurse would be done with it quickly. I open the door. Jessica. A look of shock on her face. A gasp. Try and close the door as hard as I can. Left stump jammed in between the door and the frame, foot pushing against the door itself. No one needed to see me like this, especially not her. She was stronger than me though, pushing the door as hard as I was. “Wait, Koji… wait! Just open… the door!” “N-no! I can’t! N-Not like this!” She let go. The door slammed shut. I slid down it, knees on the floor and hands still pushing fruitlessly. “Koji…” a muffled voice on the other side. “I… I didn’t mean to startle you. Just… put something on, the nurse sent me.” I didn’t want to. I shouldn’t have to. But something deep inside told me it was okay, if I covered up. I don’t know what animal instinct it was, but I guess it was a desire for human contact. And information. If Mik- Misha had known about Jessica and I’s lunch, then Jessica would surely know what the rest of the school knew. Whether they heard about my breakdown on the roof. Maybe there was a chance I could back outside. “O…okay.” I pulled my shirt back on. The cotton against my scarred skin felt strange, a sensation the skin hadn’t felt since it all began. Shit. I couldn’t wrap my face. There wasn’t anything in my dorm I could use to cover up, either. I held my hand up to my face and covered my eye and upper cheek. If this wasn’t a cliché I didn’t know what was. Maybe having hair that covered it entirely. I opened the door and let Jessica in. “I’m sorry, I really didn’t know you’d be, well, like that. Actually, I didn’t know at all what was under your bandages. I don’t think anyone does. And I didn’t expect you to be naked when I walked in.” I clearly looked upset, because she apologized. “That was a joke, sorry. Anyway, the nurse said you missed yesterday’s appointment. He usually comes here then, he said, but thought it might be better if someone else managed to get you out. He’s worried, even though he won’t say it.” “W-Wasn’t there… a game today? Y-You know… away…?” “Oh, that. It’s not important. I go to every game, I can afford to miss one. Besides, the Nurse thought it was important to get you out. I trust his judgment.” “W-well… okay. T-Thanks-s for… coming, I g-guess.” “Ah, it’s nothing, really! So hey, need help with those head bandages? They seem pretty hard to get on by yourself…” She grabbed one of the cotton strips off the bed and stretched it out between her hand and under her armpit, looking like she was picturing how to best wrap my head up. The bandage, and her hand, were really close to my face. I panicked. “NO!” She was startled, her eyes growing wide. “I… I m-mean, no thanks… I don’t like people… touching me. W-without…. Gloves. For p-protection.” “Well the Nurse said you were fiiiiine, but have it your way. Heh, I don’t think anyone will recognize you without them! But let’s goooo, I told him I’d get you back there as soon as possible.” And like that she opened the door back up and led me across the grounds. This was clearly a step between not wanting to disappoint her and not wanting to get in trouble the nurse, but it was frightening. I had both hands covering my face, which made it even more conspicuous. So long as no one saw, I thought, I’d be fine. How ridiculous that was though. Like no one would notice the foreign girl leading a guy covering his face with his hands all across the school. Why was I even doing this? I’d be fine alone. Keeping up with Jessica is hard, she’s practically sprinting there, but we make it soon enough. “Hey, I’ll be out here when you’re done,” she smiles, “we’ll go get coffee or tea or something.” Gulp. I hope she didn’t hear that. But for some reason I can’t say no to this girl. So I just nod and head in. “Ah, there you are.” The nurse looks a bit pleased to see me, but this quickly changes. “I hear you had a rough afternoon yesterday.” I just look at him, unsure of what to say. “Misha’s an old patient of mine, as you might of have guessed. She used to come in here every once in a while when she was going to Yamaku. For her disability. Anyway, she came to me after you freaked out on her yesterday – which you should stop doing, you know, if you don’t want us to get worried – and was asking all about you. She’s a sharp one, figured I’d know most about the guy with the bandages.” He was smirking now. “So, let’s get your medicine out and get you some bandages. Only three more days of this you know? And, shoot kid, you made it all the way here without ‘em and didn’t die. You might not need this crutch anymore.” I guess I hadn’t though of it that way before. I thought they were helping me heal, not sheltering me. In that way they were better than any locked door or computer screen. * * * “Hey, look at that! All fresh and ready to go?” Such a positive attitude after the 30-minute wait. This girl was something. I just shrugged meekly in return. Where would she take me next? I hadn’t gotten the chance to talk to her yet, so I couldn’t refuse. I don’t think she’d let me anyway. “Y-you weren’t… bored, w-waiting?” “Nah, I’ve got some games on my cellphone!” She whipped it out of a pocket in her skirt I didn’t think she’d have. “It’s a lot easier to play games one handed on one of these, you know what I mean?” I nodded and followed her outside. “W-where are going?” I asked as we passed through the gate. That gate that was the first barrier of defense against the outside. Kept me protected and kept everyone else protected from me. She seemed pensive, thinking about it hard. “Well it’s a bit early for a big meal… and I don’t eat fast food… too late for a picnic… that settles it!” “Hmm?” “The Shanghai!” Her eyes lit up like she’d just made a major breakthrough. She got so excited over the little things in life. It was kind of infectious. “T-the… Shanghai?” “Yeah, it’s this nice little tea house. But don’t worry; they serve pretty good food there. And they cater to students a lot from Yamaku so they’re all used to us freaks marching in and out all day long.” Glad to know that she thought of herself as a freak, too. Admittedly, her disability was just as visible as mine. I should really stop making seeing jokes, it feels too self-depreciating. So down the hill we went, a few turns through the narrow streets of the town and we were there. It occurred to me that we were deeper into town than I’d ever been before. The convenience store was right there on the main road, I had no need to go around town at all. She noticed. “First time into town?” “W-well I… I usually just go to the convenience store. F-for… lunches and things.” “You should get out more, you know? Even in just this small town there’s lots to do. Not as much as the city of course, but still things to do and places to go. Ah, we’re here.” Old fashioned and unassuming, the Shanghai didn’t look like a place Jessica would come to. I guess I can’t say that though, I don’t know her that well. Inside it was even more old fashioned than outside. High backed booths ringed the outside though. That was good, nice and private. There was a clatter and a couple of loud thumps from the back as we came in. “W-Welcome to the Shanghai!” A voiced called from in the back. “P-Please sit wherever you like and I’ll be out in a minute!” “The corner over there alright, Koji?” Jessica pointed to a secluded private booth. “Y-yeah, that one looks… good, I guess.” Almost immediately after we had sat down a woman, about 30, with reddish hair and glasses, joined us. Jessica clearly knew her. “You didn’t have to rush Yuuko, we were fine waiting!” “T-the customer always comes first! I can finish the dishes later.” “Oh, Yuuko, this is Koji. Koji, Yuuko.” “N-Nice to meet you,” I said. “Yuuko used to be Yamaku’s librarian, but now she’s off doing bigger and better things! How goes your university studies, by the way?” “I-I thought I was good at Latin and Greek before… but this stuff can be so overwhelming. But at the same time, it’s really fascinating.” Her expression of bewilderment almost made me feel like she was overwhelmed all the time, but it probably wasn’t proper to mention it. “She’s studying Ancient History at the university in the city, and if she thinks its tough, I’d probably die. I’m no good at history at all. “I-It’s not that… tough,” I replied, “It’s a-all about seeing the… story of it. L-Like people always wonder why there was a second world war so soon after a first… it’s because of the first one that the second one even happened. G-Ger- er, your country, was left depressed and bitter and spent years planning a comeback… and the c-cost of war on Europe allowed us, well, J-Japan to expand… when such forces were allowed unchecked i-it was inevitable.” “Hmm. I guess you really like this stuff too. You should tutor me in it, I’m always almost failing…” I noticed Yuuko was shifting her weight back and forth, a bit uneasy. “W-We should order now, r-right?” “I completely forgot! Yes, let’s! I’ll have a turkey sandwich and some black coffee. Koji?” “A s-sandwich for me t-too… and some regular tea. S-skim milk, if you have it.” “I’ll check,” Yuuko said, “Will that be all?” We nodded in near unison and she hurried away. “So Koji, you’re not from around here, are you?” I shook my head. “Me neither. Well I mean besides the obvious. Up until my dad retired our official residence was in Berlin, but I grew up in Shinjuku. Tokyo has always been my home moreso than Germany. Every time we went there, for confrences or state visits or to go see family or something I felt so out of place. Sure I spoke the language and knew all about Germany but… there’s nothing like home, right? I think that’s why my dad decided to stay here, after the accident and retirement. He knows that I like it here better, am more used to things here.” Her eyes tensed up and her brow furrowed. Her lower lip quivered. “Wow, I didn’t expect to tell you all that on our first date.” I practically threw up. She laughed, really hard, a deep belly laugh. “I’m just kidding you, dude! She kicked me under the table. “Stop thinking so much. Anyway, where are you from?” “K-Kago… Kagoshima. A small town… near the water.” “Woooow, Kyushu? That’s really far south. Hmm. I guess you’re really unused to living here, where it actually gets cold.” “W-Winters are really warm… well, warmer than here. It’s different being here. Being away from the ocean.” “Well we have an ocean here too you know. You could probably take the train or something.” I shrugged. “I-I like Yamaku… and the town. Small and i-isolated… like home.” Too bad there were people here though. “Yeah, it’s pleasant, isn’t it? Relaxed and all that. I’ve gotten to see a lot of the prefecture too, thanks to the soccer team. Compared to the hustle and bustle of Tokyo… it’s relaxed. That’s the best word for it.” Yuuko came over with a tray, two sandwiches and the two hot beverages. “We, uh, didn’t have skim… Is one percent okay?” I nod and Yuuko bows and leaves. “Looks good, eh Koji? Let’s dig in.” The girl was ravenous. A minute passed and the sandwich was gone. Sandwiches seemed easy enough for her to eat, though she had to put it down to take sips of her coffee. I suppose if she had both hands it’d only take 30 seconds to finish the meal. “Ahh, that was good. I always like coming here; turkey is so exotic around these parts. How’s yours?” “G-Good… the tea is good too.” “Glad to hear it. I needed the caffeine shot from this coffee. Usually I have some energy drinks or something before practice, you know? It gives me a boost I need to playwellandogoodinclass – whoa there, fräulein, too much too fast.” She exhaled and calmed herself down. “F-Fräulein?” “Yeah, it’s a German word… it’s what my dad calls me sometimes. It means young girl or something like that. It’s antiquated but my dad’s an old fashioned guy. Speaking of language, do you speak English?” “Y-yeah.” “Thought so. I saw your computer was running in English and you were talking to someone in it. You must be good at it if you use it as the primary language on your computer!” “W-Well I was always watching old… American movies. I guess… I j-just picked up somewhere along the way.” “<Well this is great, someone I can talk to in Englisch! I can’t tell you how bad the people in my class are.>” “<S-So, you speak Eigo, too?>” “<And Deutsch, Putonghua and Nihongo!> My parents made sure I’d be prepared to talk to anyone they met. Such is the life of a diplomat’s daughter. Comes in handy though. <So, what are you doing after this?>” What kind of question was that? I was going to go home and sleep, probably. Teachers didn’t seem to care if I did my homework or not after I missed class so I’d just show up tomorrow and be done with it. “<N-nothing…> I guess.” “Want to play more Portal with, er, for me then? <Turn on the English audio this time, I’m pretty sure the seiyu are putting more effort in, because it’s their game.>” “S-Sure… we can d-do that.” I reach into my pocket for a ten-yen note. “No dude, I got this. What’s the fun in being an aristocrat if you can’t give your friends some free meals?” Friends. “I-I just…” “Don’t want to owe me? Forget about it.” From the same strange and hidden pocket she keeps her cell phone a wad of banknotes soon appeared. She put down more than enough for the bill and leads me out of the restaurant, shouting a goodbye. The walk back up the hill is uneventful and silent. Jessica doesn’t seem to mind the silence though, despite being one of the most talkative people I know. She’s got this ear-to-ear smile on her face as she walks next to me. I don’t know what she’s so happy about but it’s something nice to see. Her short hair is blowing in the light wind and the setting sun forms a corona around her head. The pale blond of her hair is painted a beautiful red. A setting sun and a still breeze, Jessica and I walking up the hill to Yamaku. Thinking about it, this is why she’s at peace. There’s nothing to be worried about here, during this 10-minute walk. Even if something happened we couldn’t know if we got back. Time to stop and smell the flowers, figuratively and literally. So I do. “Koji?” Jessica turns around after I stop and let the scene envelop me. Now her face is darkened, turned away from the sun. The edges of her hair are red, like fire on the mountain. She’s at the apex of the hill, the setting sun casting it’s magic upon the sky and her back. I’m in my happy place. I’m at the beach now, peaceful again. I never thought it possible. “I-It’s just… so beautiful.” I’m looking through her and around her, not at her. I hope she understands. She turns around. I think she does. “I think… I think we’re on the same wavelength now, Koji.” “T-This is the first time… I’ve seen a s-sunset like this since coming to this school.” “It’s magnificent, isn’t it? The light playing on the trees and hills. Want to just watch it for a while?” I nod and head off the road, up the hill opposite the school’s main gate. We sit down next to each other and sit there for an hour or so, just watching the sunset. It’s beautiful. This is a perfect moment. The sun has burned away all my worries. In this moment there is only the sun, universe, Jessica and myself. The sky eventually turns dark and the last bursts of sun fall behind the circumference of the Earth. “Well, how about that video game, huh?” “R-right.” Somehow playing video games in my room wasn’t quite the same as watching the sunset but it was still nice to spend some time with somebody. She was late leaving again but I wasn’t too upset when she stayed nearly to nine. We were about halfway through the game now and she was already asking to look at my back catalog of games to see what we could play next. Something similar I’d guess, with a focus on story so we could both get into it. After she left I logged on. VariableValkyrie: <Hey Jake.> Deaddrop1911: <whats shakin, bacon?> VariableValkyrie: <You’re not going to believe this. I didn’t talk to her. She talked to me. We had dinner together.> Deaddrop1911: <what like a date?> VariableValkyrie: <No, I don’t think so.> Deaddrop1911: <well be careful not to get friendzoned bro> Deaddrop1911: <its a bad feel> VariableValkyrie: <You mean feeling, right?> Deaddrop1911: <feel, feeling, whats the difference?> VariableValkyrie: <Whatever you say.> VariableValkyrie: <What do I do next? This has got me so caught up in things I’m afraid I’ll have a panic attack.> Deaddrop1911: <well youre gonna have to seal the deal sometime soon> Deaddrop1911: <you gotta make it known youre interested in her in that way> Deaddrop1911: <else shes gonna think you just want to be her friend> VariableValkyrie: <Well I’d like to be her friend if nothing else.> Deaddrop1911: <sure you do> Deaddrop1911: <but don't think youll ever be able to sweep her off her feet> Deaddrop1911: <shell only see you as a friend> VariableValkyrie: <That’s going to be hard. You know how difficult it is for me to talk to people. I can’t imagine confessing to her. My heart is racing just thinking about it.> Deaddrop1911: <well then you gotta ease your way into it> Deaddrop1911: <hang out with her and stuff but don't be a bitch> Deaddrop1911: <show her that despite your whole situation your just a normal high school guy with normal high school emotions and hormones and shit> VariableValkyrie: <This is getting complex.> Deaddrop1911: <life is complex> Deaddrop1911: <thought youd figured that out by now> Deaddrop1911: <what with all the shit you been through> VariableValkyrie: <I suppose I know what you mean. Well, I can always kill myself if it doesn't work out.> Deaddrop1911: <don't talk like that bro> Deaddrop1911: <seriously> VariableValkyrie: <Oh. Yeah. Sorry. I didn’t mean to say that.> Deaddrop1911: <its nothing> Deaddrop1911: <just don't think about it> Deaddrop1911: <anyway i gotta get my elo up so ill talk to you later> VariableValkyrie: <Be talking with you, Jake.> Deaddrop1911: <sure thing, Koji> After this long, long day I think I can afford to go to sleep early. Sleep comes as a sweet release. * * * I wake up the next morning haunted by the fragments of dreams. A sunset on the beach. Golden hair in my fingers. Rush of a train passing by. Heat from an unknown source. Transdimensional doorways. I should really start one of those dream notebooks. I wish I could have remembered this one. Class passed by uneventfully until sign language. Misha was still there. I guess she’d be there until summer break. After class she came up to me. As I expected. I was feeling great today though, my mind was thankfully elsewhere. “So Koji, coming to practice today? Roof after classes?” “Y-yeah, I’ll… be there.” “Great! Wahaha~” Her smile took up her entire face. “I’ll see you then!” Well that wasn’t as awkward or strange as I expected. I guess most people, the Nurse excluded, were happy to ignore my panic attack. Easier for me then. One more class passed. English. Then lunch. I found myself strolling slowly to my secret spot. Subconsciously waiting for Jessica, hoping she’d be joining me for lunch again. Heh. Why would she even want to hang out with me? We barely talk. Lunch is talking time for most people. However, I found I was beaten to the punch. She was already there, leaning on the brick wall and staring out into space. “Oh there you are! You’re late.” “I-I didn’t know… there was something… I was supposed to be on time for.” “You can’t watch the sunset with someone like that not expect to eat lunch with them the next day. That was some deep, introspective stuff man.” I wasn’t sure if she was mocking me or telling the truth. I decided to dodge the subject. “W-What about your other friends? The ones… the ones y-you usually eat with?” “The soccer team? Bah, I see them every day after practice. Plus they talk about the same stuff all the time. Who-likes-who, what everyone’s doing for the weekend – it’s always the same stuff – and how tough classes are. The who-likes-who stuff isn’t even fun, there are no boys around to watch squirm.” She giggled. “I’ve been having more fun with you lately, anyway.” Me? Fun? I hardly would think so, but I’m not about to tell my crush off. If she wants to hang out with a loser like me, why not? So I just shrug and sit down. Unpack the same boxed meal as last time. “Same thing again?” I nodded. “Then let’s switch. You probably could use a more balanced meal anyway. Why not? The spargel was pretty good, this couldn’t be that bad. Then I looked down at the little plastic bowl in front of me. A dozen slices of sausage, doused in some sort of red sauce and a little portion of French fries. “W-What… is this?” Jessica looked up; she had greedily dug into my boxed lunch already. “Oh, I guess I should’ve told you. It’s called currywurst. It’s pork sausage covered in curried ketchup. It’s really good and really easy to make. A staple of Berlin! Just try it, it’s better than it sounds.” I stabbed the smallest and least covered piece of sausage with the provided fork. What was I doing? I hated spicy food. Curry was specifically spicy! I slowly raised the piece up to eye level, squinting at it. Fuck it. Here goes nothing. I put it in my mouth and chewed. Surprisingly not bad. And then the spice hit. “H-hot-hot-hot!” Jessica was cracking up, her mouth full of rice. “Buff if’s grood, righf?” She was right, actually. It wasn’t half bad. She gulped down the morsel in her mouth. “It’s like the hamburger of Germany. Well maybe not, since we have those too… It’s fast food, comfort food. A national pride, in a way. Saying you hate currywurst in Germany is like saying you hate beer… though I guess that applies pretty much everywhere.” “W-Well it’s good… thanks.” “Nof proflem,” scarfing down more. The rest of the meal passed in contented silence. A little while after finishing, Jessica spoke up. “Hey Koji, do you have a cell phone?” No, I didn’t. What did I need one for? Nobody to call, my mom called over the internet and my dad and I didn’t talk often. Nobody to e-mail either. “N-no.” She seemed to move an idea about in her head, like someone chewing on a particularly large piece of food, switching it back and forth across their mouth. “Then we’ll have to get you one, then.” “W-what? W-why?” “So I can e-mail you and stuff. Think about it like this, girls always like mysterious guys, right? So if I’m e-mailing you then other people will see and think ‘who’s that guy always talking to? He’s so mysterious!’ And it’ll make that girl who have a crush on jealous.” My face turned a bright red. “W-why would I… I want to d-do that? D-Does that work?” She shrugged. “Dunno, but it’s worth a shot. Plus everyone needs a phone, what if you got lost or something? Anyway, that settles it. We’ll go into the city tomorrow and get you one. I think I’m getting used to Jessica’s impulse driven lifestyle but she just keeps ratcheting up the danger. I haven’t been to the city yet, at all. I didn’t like cities, too big and too many people. A dangerous place for someone like me. I didn’t want to go but I don’t think she’d allow that. I also might be able to confess to her. Hah, that’s rich. That wasn’t going to happen. She wasn’t interested in me, and could never be. “O-okay.” “Awesome! Well, the bell is going to ring soon, we should get going. Oh, and I can’t come over to play video games tonight, coach says I missed too much yesterday and have to make it up. Anyway, gotta go dude, I’ll see you tomorrow, bright and early. Might as well make a date of it!” Did she say date? I think she said date. “D-date?” “Yeah, day. You know, spend the whole day doing stuff there. I know lots of great shops and things to do.” With a quick wave she took off. I was spent. * * * “[Good afternoon, Koji Kawamori!] Wahaha~” Rooftop, after class. Mika- Misha was there waiting. “[Good afternoon, Misha.]” “[Ready for today’s practice?]” “[I guess so.]” “[Great! Let’s get going then.] Wahaha~” Practice was actually pretty fun. Once I started getting the hand motions more and more under control, it was easy to lose myself in the conversation. I wasn’t thinking about the stress or anything else that triggered my anxiety. I was free to just talk, provided half of my mind was focused on pulling up signs from some corner of my memory. And almost as quickly as it started, the hour was up and I was free to go. “Hey Koji, before you go…?” “Y-yes?” “I’m sorry about the other day. I know I come on a little strong but I wasn’t aware to the full extent of your… issues.” Oh great, pity. “We all have issues, especially at Yamaku. When I was a student here… well I was in love with my best friend. She was my rock and support structure.” She? “She… Shizune is a great person. I learned sign language just to be able to talk more freely with her. But in the end I told her what I truly felt. Things were strange and awkward for a while but she still wanted to be my friend. It was hard for her to make friends, because of her disabilities. So I did, heartbroken the entire time. It pained me every day and smiled with gritted teeth. So you’re probably wondering why I’m telling you all this, right?” I don’t like knowing about people’s personal lives and problems, because inevitably they want to know about mine. Then they’ll reject me. Only those who couldn’t see me, what I really was, seemed to accept me. So I just nodded, hoping to get out of here as quickly as possible. “Because if I hadn’t I’d regret it for the rest of my life. I’d be more depressed than I was when I was rejected. I would have never known, been always searching and wondering about what could have been. And I’d probably have pushed Shizune away, not wanting to face her every day. So what I’m saying is that when an opportunity presents itself, you have to take it.” That… wasn’t what I expected. I suppose she has a point, but I don’t know if I ever could. There were too many things to worry about. “Anyway, I’ll see you on Monday, kid. Hope you have a good weekend.” An ear-to-ear grin. She was back in her happy mode. “W-wait…” “Hm?” “T-hank… thank you… for telling me all that.” “Ah, it’s nothing. I just figured you could use some advice. We all need some good advice once in a while, especially from people who’ve been there before.” * * * “Man, I hate the bus. So much time waiting for it to show up, then so much time for it to get into the city… too bad I don’t have a car. Or a license.” Jessica was wearing her equivalent of casual clothes. Jeans, a green zip-up sweater and a white shirt, plain and innocuous as possible, hard as that was with one sleeve pinned up. I didn’t own anything even remotely casual so I was there in my uniform, minus the jacket and tie. “I-I don’t mind… time to think.” She sighed. “You would say something like that. At least let me be selfish some of the time.” Her tongue was stuck out at me. And at that moment the bus decided to show up. Loud, old and smelly, I was starting to agree with Jessica. It might be worth it to buy a car just for this one trip. But the trip passed by relatively quickly. The bus driver paid no heed to the kid with bandages all over his head and the girl with one arm but I can’t say the same about the rest of the passengers. This was not good. I sensed them shift away as we walked to the back. I suppose I didn’t want to interact with them, either. The bus slowly fills up with people as we get closer and closer to the city center. This is no good. All these people, all so close. I’m like a plague carrier. Everyone is in danger. Jessica is in danger. I think I started hyperventilating. The panic attack was coming. Then something grabbed my arm and clenched down. My shirt prevented skin from touching skin but I almost cried out. “Hey,” she said looking at me straight in the eyes. Small but brilliant blue eyes, the color of a pale northern sky. “Just relax, we’re almost there. Everyone’s just staring at how old fashioned your clothes are. You need to get something casual, dude.” Normally anyone, anyone at all touching me is just rife with tragedy. I don’t know how many panic attacks I had in the hospital whenever a nurse came in to check on me. But, transfixed in those eyes... I was frozen. Better than panic, I guess. “Oh hey, our stop!” She continued pulling me by the arm down the length of the bus, twisting me around while she took the lead. The city was bright and busy, people milling about everywhere on this Saturday. Tall buildings of glass and concrete stretched up to the heavens but below and in between there were plenty of traditional-styled buildings as well. Cars stuck in traffic, the noise of people’s chatter and movement, street vendors calling out their wares and the sound of frying food all contributed to a din I’d not heard in some time. Chaotic but controlled. It was amazing how all this coalesced into this one space, forming the scene in front of me. I don’t think Jessica felt the same way, however, and quickly yanked me down a different street. “The phone store’s right around here.” “A-Are you sure… sure you k-know where you’re g-going?” “Of course! I’ve never been lost. Something about an impeccable sense of spatial awareness. It’s like I’m able to sense where I am at all times in relation to other things. Or something like that. Basically, I know what direction to go and about how far to travel to reach places I remember. Sounds fancy but isn’t all that useful.” “W-well if… if you say so.” “It’s just this way!” A quick turn left and another block down and lo and behold, the logo of Softbank Mobile. The store was unassuming but perfectly suited to its purpose. Lines of phones ringed the inner walls of the store and a couple of salesmen were walking around, talking to customers and securing deals. As I held the door open for Jessica she took the opportunity to switch arms and grabbed my left. Now she wasn’t as much leading as she was holding onto my arm, and we stood side-by-side. “So what kind of phone do you want?” “A r-regular one? One that… can call and e-e-mail.” “Every phone does that. Here, look at these smartphones. Touchscreens! This one comes with lots of apps preloaded… this one was developed with Sony so you can play games… this one has a really good camera…” “I-I…” I stared at my feet. “I don’t have enough…” She did that move of hers when she appeared to be crunching numbers in her head, swishing around ideas. “When’s your birthday?” What? “N-next month…” “Then I’ll buy one for you. Early birthday present!” “N-no… you’ve already done…” “Nonsense, I have so much money in allowance from my father that I never spend. I don’t have the time to, what with soccer and studies. Here, iPhones are good. Lots of games and stuff for you to… uh…” She got caught up for a second. “W-what’s the matter?” “It’s just… Well it’s hard for me to use smartphones. It’s why I don’t have one. You need two hands for a lot of things. Heh, maybe I’ll just live vicariously through you some more.” She was back to grinning. “Excuse me, sir? Yes, we’ll take it. Just the one.” A slap of some plastic and a few documents to sign and there I was, proud owner of a cellular phone, courtesy of one Jessica Frederson. “We’ll check it out later, but right now I made reservations for us at a restaurant. And then we’ve gotta go get you some new clothes. I don’t mean anything fancy, it’s just you look like you should be back at school. Sometimes you need to dress a little less formally, dude.” There was a trill noise from Jessica’s phone. She dropped my arm and went into her pocket to answer it. I realized just how much she was limiting herself by holding on to me. * * * Some hours later I figured it was time for a break. “H-Hey… there’s a vending machine… I’ll buy you something.” “You don’t have to, you know.” “It’s the l-least… after all you’ve d-done…” “Alright then. Hmm, is there peach juice there?” I slotted in the cash and bought her a can of peach juice and myself a bottle of water. “Y-yes, h-hear you go.” She took the can and placed it in between her stump and body. With her free hand she tried to pop the top but the can slipped out and fell to the ground. She picked it up and tried again but it clattered to the ground. “H-hey… do y-you...?” “No no no, I can… I can do it myself…” She was gritting her teeth, almost snarling. It fell again and popped open, spilling juice all over the sidewalk. “D-DAMMIT!” She grabbed the can and flung it at the nearest wall. The tinny metallic sound of the can rattling on the ground was deafening. Jessica fell to her knees and started sobbing. I dropped the bags to the ground and went over to her, picking her up and embracing her in a hug. What was I doing? Some sort of animal comfort instinct or was this more? Ignoring my condition, her condition? Her one arm was coiled against my shoulder, grasping my shirt. Tears from her face pushed up on my chest seeped through to my undershirt. “I-it’s so… so frustrating some times. I’m fine, I’m really fine,” she said through tears and sobs, “but then, fuck, it’s like, even the most basic things like answering a phone or o-opening a fucking can of juice… and it’s never coming back, never. Its not like it can get better… I’m missing my arm for the rest of my life. …You understand me, don’t you Koji?” “I do.” I self-consciously looked away, she was looking right at the bandage where my eye should be. “I mean, I even have to keep my hair this short because it’s too hard to have long hair, brushing and styling and…” “I-I like it… like it is.” “W-what? Oh.” She smiled. “S-Sorry about all that,” she said breaking the hug, “sometimes these things get to me. I’m better now. Come on, we should get back to Yamaku.” She helped me pick up the bags and then grabbed my sleeve again, like before in the phone shop. Side by side, not quite holding hands but close enough for me, for right now. The ride home was uneventful, but she stayed attached to my sleeve the entire time. Something about her presence was calming and suppressed my baser urges to flee or panic. I was too content to consider the implications. It was late by the time we got back to Yamaku. We’d missed the sunset while riding on the bus. She dropped my arm when we passed through the gate. “I’ll see you later, Koji. I had a lot of fun today.” “M-me too… thanks for e-everything.” “Get some rest, you look tired!” She took off like a flash, as per usual. I somehow managed to drag myself into the dorms and collapse on my bed. There was a lot to process about today. About myself. She was clearly touching me for large parts of the day, not my skin but touching me nonetheless. And I didn’t freak out. Perhaps this was some kind of hormonal thing? Being a teenager? Was it… emotional connection? I was too confused. I’ll ask Jake about it later. * * * VariableValkyrie: <Hey Jake. Got a minute?> Deaddrop1911: <if im on you don't even need to ask> Deaddrop1911: <lol can wait> VariableValkyrie: <Thanks buddy. So yesterday… Me and Jessica spent the day together. In the city, hanging out and stuff.> Deaddrop1911: <where did this come from?> Deaddrop1911: <I mean i knew you had it in you bro> VariableValkyrire: <Well after dinner, we’ve been getting lunch and stuff. Then we hung out yesterday, you know, outside of a school context.> Deaddrop1911: <congrats> Deaddrop1911: <did you confess or whatever you japs call it?> VariableValkyrie: <No. But she did hold my arm. She knows about my not wanting to touch people, so I think it was as close to holding hands as I could get.> Deaddrop1911: <she has to like you man> Deaddrop1911: <accommodating your paranoia> Deaddrop1911: <nobody just fucking does that> VariableValkyrie: <I guess so. Are there like signs, I should be looking for?> Deaddrop1911: <yeah, there’s a big one> Deaddrop1911: <holding your arm because your too chickenshit to hold her hand> Deaddrop1911: <she only has one, thats a pretty big commitment and sign of trust> Deaddrop1911: <it means shes relying on you> Deaddrop1911: <even if she doesnt know it thats what it means> VariableValkyrie: <But I’ve been relying on her. To talk to people, to get outside.> Deaddrop1911: <sure, sure you say that> Deaddrop1911: <but friendships> Deaddrop1911: <and relationships> Deaddrop1911: <are mutual things. Shes opening up and relying on you just as you are on her> Deaddrop1911: <big fucking sign there, bro. fucking times square of signs> VariableValkyrie: <So what do I do now? I’m fucking scared, I don’t want to screw this up.> Deaddrop1911: <ive been telling you since the beginning> Deaddrop1911: <fuck reason and timing> Deaddrop1911: <man up and kiss her, tell her how you feel> Deaddrop1911: <i dont think youll be rejected but even if you are it doesn't matter> Deaddrop1911: <you fucking went for it, know what i mean?> VariableValkyrie: <I think so. I’ll try, maybe tomorrow. I’ll see what she really thinks of me. Bandages are coming off.> Deaddrop1911: <shit man, fucking finally> Deaddrop1911: <but if shes already attached to a man she can barely see> Deaddrop1911: <im sure youre golden> Deaddrop1911: ;) VariableValkyrie: <That’s a stupid emoticon.> Deaddrop1911: <whatever bro> Deaddrop1911: <don't disappoint me> Deaddrop1911: <and more importantly don't disappoint yourself> VariableValkyrie: <Thanks. You’ve been a help.> Deaddop1911: <no problem, its practically my job now to make sure you don't follow in my footsteps> * * * Fighting a snake-man. A mountain on fire. Laying on the beach at home with Jessica. A torrential downpour. I really wish I could remember more of my dreams beyond these flashes. * * * Monday afternoon. I was in the Nurse’s office. Today was the day, the last day I’d be covered up. At lunch Jessica had told me to call her when I was done, we’d go celebrate. Whatever that means. The Nurse was looking over some charts and I was sitting on the examination table. I couldn’t say I wasn’t apprehensive, but Jake’s advice kept resounding in my head. She was attached to a man she already couldn’t see, whatever was underneath couldn’t be that bad. Or so he told me. Jake wasn’t exactly Don Juan. “Hmm, I think my predictions were correct. Bandages completely off today. You’re going to have to be careful though, the tissue is still very raw. When you come to take your pills we’ll apply some ointments and such to keep it healing. Now strip.” Sometimes the Nurse’s attitude was a little too frank. But I complied. I took of my shirt and placed it gently on the table next to me. Gingerly, the Nurse began to peel off the layers of bandage from my head, neck, shoulder and upper arm. It hurt but I was so used to this that it barely registered. The nurse then grabbed a variety of tubes filled with some sort of gel or cream substance and gently applied them. “Moisturizer. Makes it look better.” He peeled off his gloves and marked something down on his clipboard. He opened another drawer and pulled out a small plastic bag with a black thing in it. “Here, you’ll need this for now.” I opened the package. An eyepatch. I nodded to the nurse and put it on. It fit pretty well. The Nurse adjusted it; he didn’t seem to have any mirrors handy. Well I guess it was better than nothing, raw eyesocket would greatly disturb a lot of people. Myself included. “Alright, get out here. You’ve got stuff to do these days, right?” He winked. I shrugged and dressed. When I was outside in the hallway I pulled out the phone. My phone. I was still getting used to it, all this touching and swiping and apps. Luckily I only had two numbers in it so far, Yamaku’s Emergency Service number and Jessica’s. I pressed the nonexistent button to call her. Ring. Ring. “Hello? Koji?” “Y-yes… it’s me.” “All done?” “Y-yeah.” “Great!” She paused. “Hmm, I’m just in the middle of some homework, why don’t you come by and wait for me?” Go to the girl’s dorms? Her dorm room? “Uh… o-okay.” “Great, see you in five! Oh, and it’s room 308.” There was a snap of her closing the clamshell of her phone shut. Don’t think about it Koji. Just let your body go, let your mind drift onto something else. Autopilot yourself there. 5:00 on a Monday afternoon meant the grounds were pretty deserted. Most of the students with free time were off in town and those with clubs were doing homework but it wasn’t yet time for dinner so the crowds weren’t streaming towards the cafeteria. Safe time for me. I really didn’t want anyone to see my like this, not yet. The Girl’s Dorm was just across a small courtyard from the Boy’s. A mirror image, actually. There was a strange painting on the wall next to the stairs leading up to the courtyard, apparently done by one of Yamaku’s students a few years back. A large mural, it conveyed all sorts of emotions to me, from pain to love to anger. There was a student outside, sort of just skulking around the building. I recognized him, Takeshi Kaneda from 3-1, Jessica’s class. I wonder what he was doing waiting out here. I guess he saw me looking because as soon as I stared for too long he turned and walked towards the girl’s dorm. I suppose I’m not the only one who shuns most human contact. When I reached the entryway, I was surprised to find a guard posted. A large sign above the middle-aged woman said: ‘ALL MALE STUDENTS MUST SIGN IN AND SIGN OUT’. That was strange; there was no such restriction in the Boy’s dorms. I went over to the desk. “Hello there, sweetie, you need to sign in here, and what room here.” I quietly wrote my name and 308 next to it. “Oh, so you’re Frederson’s new friend. Pleasure to meet you, I’m Fujiyama.” “P-pleased to meet you.” “Surprised?” I shook my head up and down. “She comes down to talk to me sometimes. You know how friendly she is. Always eager to share. Run along, I’m sure she’s waiting. I know how impatient she is, too.” I bowed and walked down the hallway, then up two flights to the third floor. Room 308 was on my right out of the staircase, according to a sign on the wall. Take deep breaths, I thought. It’s just another room, probably no different than your own. Well, maybe not as clean. But you came here for a reason. Tonight you’re going to tell her. I knocked. “Yes, who’s there?” Her voice from inside. “I-Its… uh, me, K-Koji.” “Oh great! Door’s open.” There was a sign this definitely wasn’t my room. I grabbed the door handle and opened up. It didn’t seem that messy. Her room was arranged similarly to mine, but instead of a big desk there was a dresser. Her bed was larger. And there were clothes, everywhere. No sign of a lot of makeup or anything, I guess… I guess that would be hard, too. Piles of books and magazines were scattered around. Okay, it was pretty messy. She was laying on her bed, stomach down and a book in front of her. She was propping herself up on her left arm and writing down answers to her homework with her right. Her legs were bent backwards, sort of hanging in the air above her. When the door opened she turned around and sat cross-legged on the bed. “Wow Koji, you look really great! Come on, sit down.” “T-Thanks.” I sat down on the bed next to her. “Have you looked at yourself in a mirror yet?” I suddenly noticed the large mirror on the dresser across from the bed. I wasn’t what I was expecting. What was once a mottled layer of acne scars, discolored skin and the remnants of infection was now a series of lighter red patches and a striated pattern. It wasn’t really bad at all, though certainly noticeable. Sections right jawline and neck were erythemic and taught, where skin had to be removed and replaced, and looked more like burn scars. The eyepatch was fitted snugly over my eye, the black elastic material stretched across my hair and the scarred section of my face. My hair was messy and short, but they were right in the hospital. After it had been shaved off any amount of length was good. “I’m serious, you look fine. The eyepatch is badass, too. Like you’re a pirate or Big Boss.” “I-I don’t want it… the fake e-eye. It’s j-just going to... to look f-fake.” “Know what you mean dude. Why do you think I don’t use a prosthetic? If it doesn’t work the same, look the same and requires more maintenance, what’s the point. A hook is no arm at all. Heh, if I did have a hook we could be pirates together.” I laughed. An actual laugh. I surprised myself. “S-so why do I have to sign in… I’m s-sure there’s nothing l-like that in boy’s dorm?” “Oh! You met Fujiyama then. She’s a nice lady. Well the story is, some guy three or four years back went around installing cameras in the hallways. Claimed to be watching ‘the feminists at work’ or something like that. A bit crazy. Anyway, since then boys have had to sign in. I guess it makes sense, what with this being a high school… with really private rooms.” She blushed. I didn’t know why. “T-That… makes s-sense… but can’t girls j-just go into the Boy’s r-rooms instead?” “I guess. It’s not a perfect system; I mean you still got in. We could be doing stuff right now and nobody seems to care.” Okay, now I was blushing. “So, I don’t think I’m getting this homework done. Shall we go celebrate?” “W-What did you have… have in m-mind?” “Well, I though we could go back to the Shanghai. Nothing fancy, you know?” Sounded great to me. I nodded. “Alright, let’s be off then. “ She hopped off the bed and put shoes on. I opened the door for her and then shut it. “A-Aren’t you g-going to lock it?” She shrugged. “Nah. Nothing in there for anyone to take, anyway. Not like your rig. Lets gooooo, I’m hungry.” Waving goodbye to Fujiyama, we left the girl’s dorm together. I thought I saw blinds on a first-floor room in the boy’s dorm close but I think I may have been imagining it. Once we left the main gate and were about 20 meters away, she leaned over and grabbed my arm again, without a word. I’d be scared half to death if it wasn’t such a reassuring gesture. Once we got to the Shanghai she had to break the hold for me to open the door. A strange feeling of loss came over me. I wanted to continue… just being connected to her. But I was scared as hell to initiate something, to touch her myself. “Just sit wherever you like!” Yuuko called from the back. A few seconds later she was blundering over to our table. “Hello Jessica, oh and Mr. History! No… bandages anymore?” “Nope, he’s all healthy now. Nothing left at all.” Jessica was grinning, proud of me for some reason. “Well that’s great to hear? A turkey sandwich and coffee?” “Sounds good! Koji?” “T-The same sandwich… and tea, p-please.” Yuuko took down our orders and scurried away. “…I’m serious Koji, without the bandages you look really good. The scarring isn't even noticeable at this point.” Subconsciously I covered my face with my hand. “T-thanks, I appreciate it… I really d-do.” “So I was talking to my dad earlier…” Where was she going with this? “Y-yeah?” “Mhm, well I mentioned how I had a friend who really likes the beach and well he volunteered to take us next weekend. That is, if you want to go.” She was acting nervous. Strange for her. I must admit I really missed the ocean. Being this far inland was something I thought I’d just have to deal with. An opportunity to go would be great. But then I’d have to meet her father. I’d have to do a lot of things, a lot of explaining. She seemed to notice my indecision. “We don’t have to. It’s just something I thought would be nice.” “N-No… I want to g-go… it’s just I… I…” I vaguely gestured to my face. “Oh, don’t worry about that. My dad doesn’t have any legs.” She giggled. “I think he’ll understand about your condition, if he even asks.” Well I suppose that would make things easier. Common ground between us. I was still curious why she was doing this though. “O-okay then.” I gave her a brief smile. “B-but… why-“ I was cut off by Yuuko arriving with our food. “Ask me later, I’m starving after practice!” She greedily began devouring her sandwich. I took my time with my tea and sandwich but the whole meal went pretty quickly. Yuuko soon came over with the bill and to clear the dishes. “Hey Yuuko, what time is it?” She was startled by the question. “W-what? Oh… A quarter after 6.” “Hey Koji, we gotta go. Don’t want to miss the sunset, right?” She peeled off a yen note and grabbed me by the arm, practically yanking me out of my seat. Before I knew it we were working our way up the hill towards school. Jessica was right though, the sun was just beginning to set in the distance. The same kaleidoscope of colors was burning its way across the sky. I looked over at the girl who had now hooked herself on to me, not grasping me like before. We were walking arm in arm… like a couple. My face was beet red. Maybe now was the time to speak up. It had to be. “L-let’s go w-watch it again. On the h-hill.” “Weeeell I was going to do some homework, but I’ll make an exception, just this once.” She winked at me. We had to disentangle to walk up the hill because of how steep it was. I let her sit down first then sat down on her right, her arm safely in between us. The sky was beautiful. Jessica’s eyes were darting around, looking at all the different colors and combinations. I kept mine forward, too. Her hand was planted firmly on the grass, holding her up while she leaned back. We were sitting about 20 centimeters apart. Slowly but surely I slid my hand across the grass, closer to hers. I was doing it, I was going to touch her skin. I opened my hand and put my fingers over hers. I held this for a few seconds. A few seconds too much, I thought. My fingers were trembling. Then I felt something. Her fingers met mine and intertwined. Her skin was soft and smooth and her fingers soft and delicate. Our warmth swelled and combined. Some tension in her back seemed to be relieved and she let out a breath. She turned and crossed her legs, looking right at me. Completely open and ready. Keeping our hands together, I got onto my knees and moved over her. I had to do this. I had to do this. I had to do this to prove to her. I had to do this to prove something to myself. She slipped her legs between mine and pulled me down over her, laying down onto the grass. I was holding myself up with one arm. I leaned in and something instinctive, animal in my brain kicked in. I closed my eye and pressed my lips to hers. Sparkles in my brain. Electricity flowed between us. If this was a cartoon there’d be a giant heart growing in the background where the sun was. After a lifetime, I pulled my head back. “It was about time.” She giggled at me. She let go of my hand and put her arm around my neck, pulling me back down for another kiss. “I-It’s you… the girl I-I have a c-crush on… the girl I l-like… it’s y-you.” “I know.” End of Act 1. Act 2: Climate “[So Koji, what’s new?]” It was the day after. Jess (she told me I should call her Jess, I suppose I hadn’t said her name much at all before) and I spent the night playing Fallout: New Vegas. And then there was more kissing. A kiss goodnight was perhaps the best thing I’d ever experienced, apart from the first kiss. All day today I was walking around on cloud nine. Some people seemed to notice the eye patch but nobody said anything. I couldn’t care, anyway. Lunch was great, too. With no one else in the alley we were free to be a physical. So now I was on the roof, practicing with Misha. We’d finished the basics for the day and now it was free conversation time. “W-what? [What?]” “[You just seem so happy today. And you keep drifting off somewhere.] Wahaha~” “[Nothing. Just got my bandages removed.]” “[I noticed that, you look great! But I think there’s something else too. Let me guess… That girl!]” “[I don’t know what you’re talking about.]” “Suuuure. [I’ve heard this before. Well, deny it as much as you can, but I know that loving look. Head over heels. But it’s a good look, it means it’s being reciprocated.] Wahahaha~ Congratulations, Koji.” “[Thanks I guess, it’s really not that though.]” “[You’re free to go though, see you tomorrow.]” “[Thanks Misha.]” I gathered up my books and walked down the stairs to the first floor. Out the doors and headed straight for the soccer field. Forget whatever anyone would think. As Jessica’s… boyfriend, I had to be there to support her. Or whatever. I wanted to go and I’m not going to let my anxiety get the better of me. I walked into the stands and took a seat. There were a few other students around, but with weekly games I suppose there wasn’t a big push to go to every one. I saw a single familiar face, it was that kid Kaneda. The match was against Seiei Academy and Yamaku was losing 1-2. I saw Jessica charging down the field. She told me that besides captain, her position on the team was ‘left forward’ and her job was to score goals. Supposedly this left her more open to come up with strategies on the fly, she didn’t have to worry about defending or anything else complex, just to score goals and tell her team what to do. The match was fierce and both teams were really good. Yamaku’s goalie only had one leg and a lot of the players seemed to have arm disabilities. I guess when you lose one thing you make up for it in other ways. I arrived right at the beginning of the second half. Yamaku was doing all it could to prevent Seiei from scoring again, to prevent a greater lead. Jess was barking orders all around the field, completely in her element. With 20 minutes to go one of Yamaku’s players took a dive, apparently injured. There was no one to replace her. Jessica looked concerned and helped her off the field. When play resumed, she quickly took control of the ball, pushed it downfield and scored. The small crowd let out a cheer. I looked around when the crowd was celebrating. Kaneda was gone. Unfortunately Yamaku didn’t score again. The game ended in a tie. The teams shook hands and congratulated each other for a good game. Yamaku’s team gathered for a talk from the coach and then broke off into groups, friends heading back to the dorms to get changed, bringing equipment to the athletic shed and that sort of thing. Jess looked around at the crowd, saw me, waved and then ran to the stairs going up the bleachers. As I stood up to greet her she embraced me in a hug, or as best a hug she could do. “You stayed the entire game for once!” “I-I figured… since w-we’re uh… well y-you know…” She laughed and let me go. “Thanks, I really appreciate it. We need more fans anyway.” She quieted her voice. “Have you told anyone yet?” “N-no… I d-don’t really have… anyone… to tell.” “Hmm, well I guess I’m fixing that. I didn’t tell anyone either. I think it’d draw attention to you, which I know you don’t like. I mean, we’ll have to soon enough, but for now it’s a great little secret! Or big secret I suppose. Anyway, I’ve got to go get changed. Coach is making dinner. But I’ll be around your room later, ok? I owe you a kiss for then.” She took off. So she was thinking of me. To be honest I didn’t feel great being handled with such kiddie gloves but she knew the social sphere better than I did. If it would cause a commotion like she believed it would I’d be glad if it progressed slowly. After my regularly scheduled appointment with the nurse, I went back to my room and started on my homework, but quickly got bored and logged on my computer. Deaddrop1911: <dude come on ive been waiting> Deaddrop1911: <you haven’t been on in two days> Deaddrop1911: <what fucking happened> VariableValkyrie: <I told her. You were right, she knew and reciprocated. We kissed. More than once. I think we’re dating now, but it’s a secret for the most part.> Deaddrop1911: <see what happens when you man the fuck up?> Deaddrop1911: <good fucking things happen> Deaddrop1911: <so did you put it in yet> VariableValkyrie: <No no no> VariableValkyrie: <I’ve never done anything like that, I want this to progress naturally. Can’t be rushed.> Deaddrop1911: <lol I know> Deaddrop1911: <not like youd bang her anyway> Deaddrop1911: <make love that seems your thing> Deaddrop1911: <for a guy who hates when people touch him you certainly are touchy-feely> Deaddrop1911: <howd that go by the way, trying to touch her> VariableValkyrie: <I just put everything else out of my mind. Focused on what I really wanted and just went for it. Since then she’s been initiating stuff like kissing, but I took that first step.> Deaddrop1911: <looks like you found the right girl> Deaddrop1911: <here I was thinking I was the only one whod put up with you> Deaddrop1911: <lol> VariableValkyrie: <Thanks for the vote of confidence, ‘bro.’> Deaddrop1911: <hey man I got you to do this> Deaddrop1911: <my powers are stronger than you think> My phone buzzed. An email from Jessica: ‘too much food here, don’t worry about dinner I’ll bring some leftovers over later. <3.’ VariableValkyrie: <Signing an email or SMS or whatever it is you Americans use with ‘<3’ is a good thing, right?> Deaddrop1911: <texting, tahts what we call it> Deaddrop1911: <but yeah, very good> Deaddrop1911: <especially, after, you know, youve already kissed her> Deaddrop1911: <why whatd she say?> VariableValkyrie: <Just that’s she’s bringing me dinner later.> Deaddrop1911: <yeah shes head over heels for you bro> Deaddrop1911: <just wants to spend as much time with you> Deaddrop1911: <I say let her> VariableValkyrie: <We’re going to the beach together next weekend.> Deaddrop1911: <what like your beach> Deaddrop1911: <like at home> VariableValkyrie: <No, the one here. Home’s too far for a weekend trip.> VariableValkyrie: <Her father is taking us there.> Deaddrop1911: <her dad?> Deaddrop1911: <good luck> Deaddrop1911: <fathers are really protective of their daughters, you know?> Deaddrop1911: <gotta make a good impression> Deaddrop1911: <anyway whens she coming over?> VariableValkyrie: <I’m not sure, an hour or two likely.> Deaddrop1911: <lets play some kf then> Deaddrop1911: <get some dosh> VariableValkyrie: <Alright, I’ll see you in-game> * * * Knock knock knock. “I-I’ll be there in a second.” I got up from my desk and opened the door. Chain still attached. Some habits don’t die. Much to my surprise, it wasn’t Jess. Shoulder-length brown hair and brown eyes looked straight at me, pierced through me. Takeshi Kaneda. “H-Hello… can I h-help you?” “Kawamori, right?” I nodded. “We need to talk. Open the door.” “I-I’d rather not.” “Fine then. But heed my warning. What you’re getting into isn’t real. She’ll cut your heart out man.” “W-What?” “I know what’s going on. Between you and Frederson. Man to man, I’m warning you.” He turned around and walked down the hall to the stairs. What the fuck was that about? I’d never spoken to him before in my life and now he was showing up at my room, on top of all the places me and Jessica had gone too lately. This was very strange. What was he talking about? Ah forget it, it wasn’t important. It was well known that despite not catering to the mentally disabled, Yamaku had its fair share. I sat back down at my desk. Thump. A thumping noise at the door. Not quite the pitch of a knock, not a kick, more like someone was whacking the door with the broad side of their- …elbow. This was Jessica. “Koji come on open up I can’t use my hand and this bag of stuff is heavy!” “O-Okay, okay!” I got up and opened the door. As soon as it was open wide enough, she push through, got on her tip-toes and gave me a kiss on the lips. I wasn’t expecting that right away. Or was I? I really didn’t know what I was in for recently. She set the bag down on my beg and started unpacking it. “I’ve got… pasta with marinara sauce, pasta with alfredo… and baked ziti. Well rigatoni, but we tried. What do you want?” I’ve never had any of that, besides the pasta with marinara. And never home cooked. Was the coach Italian? I couldn’t remember. “W-what’s in each? I’ve n-never really had… any of those.” “Oh! Well we usually have some kind of pasta after big games and stuff. Hmm, well marinara is a tomato sauce, like ketchup but better and less salty. Alfredo is just like a cheese sauce. Not real parmesan but close enough. And baked ziti is melted cheeses and sauce, cooked in an oven. It’s my favorite.” I grabbed the pasta with marinara. Jess handed me a plastic fork. “So courteous, eager to allow his girl to have the food she wants.” She giggled and smiled, closing her eyes. I don’t know if she was joking, but she grabbed the baked ziti-ish pasta and started digging in. After eating the food (which was surprisingly good, fresh tomato sauce!), Jessica wanted to play Fallout: New Vegas. I had made her a character last time and she wanted to continue playing, or playing through me as it were. She couldn’t actually do anything but instead dictated all her moves and dialogue choices. Some time after that, she wanted to play a few games on the- er, my, iPhone. Plants Versus Zombies was apparently something she had been looking forward to. An ulterior motive behind her getting me that phone? Probably. So we sat on my bed, her on my right, phone roughly between us, playing it for… hours, it must have been. She called out positions and I merely placed the plants. And then I was playing the game by myself, I realized. Jess had fallen over, huddled in a fetal position, fast asleep. I looked at my watch. 11:30. Wow, this was later than we had ever hung out before. Way later. Past curfew, even. She was adorable, curled up like that. Innocent and at peace. I hadn’t realized it before this point but there was this constant determination, a focus in her face. Asleep it was completely gone, replaced with pure calm. It was too late to take her back, what would the guards think? What would everyone think? But I had to sleep too. “H-hey Jess… J-Jess?” She didn’t open her eyes. “Hn? K-Koji?” “Y-yeah… you fell asleep… b-but it’s past c-curfew…” “Well… I’ll sleep here then.” She smiled, eyes still closed, then softly laughed, still half-asleep. “O-okay… I’ll just stay on the f-floor then.” I was suddenly pinned by two extremely powerful legs. “Don’t you dare.” Her arm fumbled at my neatly made sheets and pushed it down. “W-what?” “Put your phone away… and come to bed.” A hand stretched out at mine. I put the phone in it and was shocked to see such a callous disregard for expensive technology. The phone wound up in the far corner near my closet. “You don’t need it now.” She was now kicking the sheets around me, trying to push underneath where I was sitting. I stood up and the sheets were at her feet. She turned and laid down flat as a board. I did my best to maneuver around her and wound up lying on the right side of the bed closest to the wall. She curled up, knees practically touching my hip and a thin pale arm reaching across my chest, nimble fingers grasping at my far flank. I pushed my right arm next to her head – arm around the shoulder, right? – and she lifted her head, allowing my arm to come to rest beneath her head. She moved her head into my armpit. It was strange, but at the same time felt very natural. I bent my arm and put my fingers in her hair. Blond locks passed through my fingers. I think I had a dream about this. Her hair was soft and smooth, but at the same time not straight and fluid like mine. It was thick and wavy at the base. “D-do you straight… straighten your h-hair?” “Hn? No.” There was a soft smile on her face. “But when it gets longer then this I need to. It’s very wavy.” I continued to play with her hair. It was oddly comforting. Some time after that I fell asleep, Jessica curled against me and my hand in her hair. * * * There was something soft and a little wet on my lips. I opened my eyes and saw Jessica leaned over me, giving me a kiss. “Don’t be so startled Koji, you don’t want to be woken up by a pretty girl kissing you?” She giggled. “N-No... it’s just… I…” “Heheh, I’m just teasing you. But I think we have a problem… I guess I stayed out past curfew. You’ve gotta help me sneak out of here.” This was a problem. Not just that we hadn’t gone public yet but staying over in a boy’s room? This could be bad. “R-right.” I pushed the sheet covering us down and Jess got out of bed, brushing her skirt down and patting the wrinkles out of her shirt. It didn’t really help, she still looked like she’d slept in them. “W-well it’s still early… only track kids are up now.” I got out of bed myself and gathered up all the garbage from last night’s feast. I put it in the bag she’d brought it in. Meanwhile, Jessica had retrieved my phone from the floor and was trying to use it as a mirror to fix her hair. With one arm this was kind of hard. “H-hold on.” I walked over and took the phone, holding it up so she could use her free hand to push her bangs back along the part. “Thanks!” She smiled one of her carefree smiles. I pulled on my school jacket. “I think this weekend you’ll be able to wear some of those new clothes of yours. You’ll look great!” “W-ha? Oh, right.” I had almost completely forgotten about the trip over the weekend. Meeting her father. I made a mental note to ask Jake for advice next time we spoke. “Ready to go?” “Yup!” “O-okay, we should go down… down the back stairway, into the first floor, uh… bathroom… and out the window there. I’ll help you out.” “I think you’ve done this before.” She winked. “W-well I uh… Sometimes there are people in the lobby.” “No need to be scared anymore, Mr. Handsome. Okay, let’s go.” I checked my watch. 6:45. 15 minutes until most people got up. Just enough time. I opened the door and peeked out the hallway. Clear. I turned and nodded to her, trash bag in one hand and taking hers in the other. We tiptoed down the hallway. There was an unlocking noise from the room near mine. We were two meters from the stairway door. A creek from an opening door. “Move move move!” I heard myself shouting. We dashed down the rest of the hallway, fumbled with the door and nearly crashed down the stairs to the landing between floors. She was laughing and so was I. “Close call!” She let out a breath. “Yeah, it really was.” I was panting a bit. “Breathless because of me? Aww, how cute!” She turned serious for a second. “You should get more exercise though. Like, don’t run track every day, but it’d help to get out more. I can come with you, if it makes it easier.” “O-okay…” She smiled. “Let’s keep moving then, in case someone hears us.” At the bottom of the stairwell I peeked through the door’s window, Jessica was flat a

2023-10-09T01:27:04.277712

https://example.com/article/9688

Oncol Lett 15: 1483-1486, 2018; DOI: 10.3892/ol.2017.7504 We would like to retract our article entitled 'The link between FOXJ1 expression level in bladder carcinoma and tumor recurrence' published in Oncology Letters 15: 1483--1486, 2018. After careful consideration, we are concerned that some of our reported conclusions in this paper may be too preliminary, and recognize the need to perform further studies. All the authors agree to this retraction. We sincerely apologize for any inconvenience that might result from the retraction of this article.

2024-05-02T01:27:04.277712

https://example.com/article/5249

Q: C++ How to have a vector of objects depending on template type I have a template class C that which should contain a vector with E objects. The E objects in the vector will store the same type as the template is. So if the C object is of type int the vector should contain E objects that contain int, if C has double then E should store a double etc. The code looks like this: template<class T> class C { public: class E { private: T value; //if C has type int then the events should store int std::string description; public: Event(std::string desc, T val) { this->description = desc; this->value = val; } }; C(); virtual ~C(); bool add_e (std::string description); private: T c_value; std::vector<E> c_vector; //this should look somewhat like [E<int>, E<int>, E<int>] }; And this compiles, but when I try to add elements to c_vector in the C.cpp file like this: template<class T> bool C<T>::add_e(std::string description) { c_vector.add(E(description, c_value)); } I get the error: 'class std::vector < C< int >::E, std::allocator< C< int >::E > >' has no member named 'add'. What is going on? How can I accomplish to store E objects which stores the same type as the enclosing template class type C? When I try so search the web I only find information about storing different template types in a vector by for example making E a derived class of an abstract class and then store abstract class pointers in the vector, but I want all of the elements to contain the same type. A: Use push_back() from std::vector

2024-02-29T01:27:04.277712

https://example.com/article/6652

import os def get_test_rss_path(): return os.path.join(os.path.dirname(__file__), 'psf_feed_example.xml')

2023-12-25T01:27:04.277712

https://example.com/article/3836

"Now is not the time for division," intones an honorable Mike Pence analog at the end of Ike Barinholtz's dark comedy “The Oath.” In Barinholtz's film, excessive partisanship and a refusal to respect other opinions has almost torn America apart. To bring our country back together, the film suggests, we need greater tolerance and respect for one another. “The Oath” thinks our current political woes have been caused by failures on both the left and the right. We could get our country back if only people were less eager to take sides. This is, unfortunately, a fantasy. But it's a fantasy that, inadvertently, shows why America has had so much trouble recognizing and responding to Trump and the rise of authoritarianism. (Spoilers below.) A brief synopsis of “The Oath” makes it sound like a dystopian warning about totalitarianism, like “1984” or “The Handmaid's Tale.” In a United States much like this one, a never-shown but erratic president has decided that everyone in the country should sign an oath swearing that they love America by the day after Thanksgiving. Meanwhile, a police-like government agency, obviously modeled on ICE, has been disappearing celebrities and opposition politicians who demonstrate against the oath, or speak out against it. In a United States much like this one, a never-shown but erratic president has decided that everyone in the country should sign an oath swearing that they love America by the day after Thanksgiving. Chris (played by Barinholtz) is a suburban dad who refuses to sign the oath. In most dystopias, this act of resistance might make him a hero, a la Winston Smith. But “The Oath” is ambivalent, even hostile, to Chris' principles. He is portrayed as an annoyingly left-wing, virtue-signaling scold, whose obsession with the news cycle poisons his relationship with his family. When he accuses his relatives of racism, his wife Kai (Tiffany Haddish), who is black, rolls her eyes. She sides against him, too, when he tells his family that they are betraying American values by signing the oath. Barinholtz plays Chris as a whiny, hectoring bully, who talks big but lacks a real spine. Faced with physical conflict, he dissolves into neurotic indecision and panic. The negative portrayal of Chris is odd because the movie shows clearly that he's right. His America is, unambiguously, descending into fascism. Members of the party opposing the president are arrested; demonstrators are shot by authorities. In a personal confirmation of everything he's been warning about, Chris himself is singled out. Agents come to his home to try to arrest him for speaking against the oath. Chris is not hysterical or overreacting; the regime is literally threatening to imprison him for expressing dissent. His relatives, who want to spend an apolitical Thanksgiving, are the ones who are deluding themselves. You can try to ignore politics, but they will eventually break into your home and splatter blood all over your carpet. But if Chris is correct that America is descending into fascism, why does the movie despise him for pointing it out? It seems to despise him in part because it blames him for contributing to the authoritarian nightmare. The movie is organized as an escalating Thanksgiving disaster. Family arguments lead to family brawling lead to physical altercations with federal agents in the living room. It's even suggested that one of Chris' family members snitched to the feds to punish him for being such a jerk. If fascism is the result of a family dispute, it makes sense that you can resolve it the way you're supposed to resolve family disputes — through kindness, apology and listening to the other side. The federal agents who invaded Chris' home, it turns out, aren't so bad, after all. "He's got anger issues," one agent says of the other apologetically. A member of a quasi-military government police force enters your house and threatens to shoot your father, but at the end of the day they’re just people, too. The bad president steps down of his own volition, everybody deescalates and everyone shares a chuckle. There's obviously some comfort in concluding that our difficulties are caused by personal animus and misunderstanding, rather than by outright malice. If the problem with our country is that people on both sides are too angry, you can just encourage those people — whether Trump or those whose homes are invaded by ICE agents — to calm down. The government should stop allowing the sexual assault of children in ICE custody; opponents of the government should stop rudely interrupting the meals of powerful people. Everyone should just be calm and reasonable. There's obviously some comfort in concluding that our difficulties are caused by personal animus and misunderstanding, rather than by outright malice. Unfortunately, authoritarians rarely simply fade away in the face of repeated calls for reasonable politeness. If you want to oppose fascism, you need to do more than just promise not to bother anyone with politics. You have to actually condemn fascism. And condemning it will probably involve bothering people. Individuals who take moral positions, and ask you to take moral positions, can be annoying. It's inconvenient and embarrassing to be told you need to stop supporting one of your favorite companies, or that you need to think harder before you speak, or that supporting the separation of children from their families may lead people to not want to associate with you. Standing for something is tiring; it's more comfortable to just sit down. “The Oath” believes that the problem with a loyalty oath is that it forces you to pick sides. Everyone has to state what they believe. No one can just opt out and treat people with apolitical decency. But the real problem with a loyalty oath is that it's an authoritarian tool designed to target regime opponents with state violence. Chris decided he would stand with those being persecuted; the rest of his family didn't. He may be a jerk, but he still tried to do an admirable thing. Attacking him for doing so — or attacking people for protesting against Ted Cruz — doesn't make you neutral. It makes you one of the folks trying to enforce the loyalty oaths. Choosing sides when fascism comes knocking isn't wrong, or dumb, or embarrassing, or immoral. Choosing the wrong side is.

2023-09-08T01:27:04.277712

https://example.com/article/5577

Connecting with God through poetic articulations of lived, embodied experience–engaging texts from the Revised Common Lectionary for Christian churches, other biblical and spiritual texts, and evocations of the divine in rituals and other public events–always accepting lived reality as a primary source of divine revelation and mystery. On Our Feet Reflection on Holy Thursday, Year A Moses told the Hebrews to prepare for their journey of liberation by eating prescribed food and marking their doors with the blood of lamb on which they feasted. They set off, on foot, through desert and sea to and throughout the land promised by God. The ancients used their feet, just as we do— dirty, calloused, twisted, arthritic, gnarled, hard or soft, massaged with oil, too, sweet scented or not, smelly sweaty feet common— all sorts and conditions of human feet. on journeys called by God. Now here is something very strange: Rabbi Jesus wants to wash our feet — even Peter’s, who, of course, objects as he always does. Is there ever a time when there is not at least one Peter in the group, one long ago offended by the idea of his Lord stooping to wash feet, like today’s recoiling at showing the imperfection of feet, even more at being asked to touch others’? Today, on Passover, Jews everywhere, believers or not, gather to share bitter herbs, unleavened bread, greens, haroset, and lamb or substitute. Most Christians avoid Jesus when it comes to feet. Strange. So many ask, “What would Jesus do?” How about: what he did? Just not with feet. A preacher said, “Jesus touched his heart and there was healing in his hands.” I want healed feet for miles ahead, years, I pray, of journeying with God. I need strong, resilient feet empowered to support journeys from my Egypts to new worlds promised again and again. I want company, too, I can’t make it alone. Let me bless yours with living water, sacred touch, our Jesus feet guiding us all the way together. About this poem . . .Every year on Holy Thursday, I am deeply moved by the washing of feet. It is such a humble act—to allow my feet to be washed and to wash others’—so like Jesus to assume the role of servant and invite us to do the same. The invitation, I hear command, is to be agents of healing and to allow ourselves to be healed by the human touch of others.

2024-03-04T01:27:04.277712

https://example.com/article/2984

Q: how to count number of requests in last second, minute and hour There is a hypothetical web server which supports only one very simple API - count of requests received in the last hour, minute and second. This server is very popular in the world and received thousands of requests per second. Aim it to find how to return accurately these 3 counts to every request? Requests are coming all the time, so the window of one hour, one minute and one second is different per request. How to manage a different window per request so that the counts are correct per request? A: If 100% accuracy is required: Have a linked-list of all requests and 3 counts - for the last hour, the last minute and the last second. You will have 2 pointers into the linked-list - for a minute ago and for a second ago. An hour ago will be at the end of the list. Whenever the time of the last request is more than an hour before the current time, remove it from the list and decrement the hour count. The minute and second pointers will point to the first request that occurred after a minute and a second ago respectively. Whenever the time of the request is more than a minute / second before the current time, shift up the pointer and decrement the minute / second count. When a new request comes in, add it to all 3 counts and add it to the front of the linked-list. Requests for the counts would simply involve returning the counts. All of the above operations are amortised constant time. If less than 100% accuracy is acceptable: The space-complexity for the above could be a bit much, depending on how many requests per second you would typically get; you can reduce this by sacrificing slightly on accuracy as follows: Have a linked-list as above, but only for the last second. Also have the 3 counts. Then have a circular array of 60 elements indicating the counts of each of the last 60 seconds. Whenever a second passes, subtract the last (oldest) element of the array from the minute count and add the last second count to the array. Have a similar circular array for the last 60 minutes. Loss of accuracy: The minute count can be off by all the requests in a second and the hour count can be off by all the requests in a minute. Obviously this won't really make sense if you only have one request per second or less. In this case you can keep the last minute in the linked-list and just have a circular array for the last 60 minutes. There are also other variations on this - the accuracy to space used ratio can be adjusted as required. A timer to remove old elements: If you remove old elements only when new elements come in, it will be amortised constant time (some operations might take longer, but it will average out to constant time). If you want true constant time, you can additionally have a timer running which removes old elements, and each invocation of this (and of course insertions and checking the counts) will only take constant time, since you're removing at most a number of elements inserted in the constant time since the last timer tick. A: To do this for time window of T seconds, have a queue data structure where you queue the timestamps of individual requests as they arrive. When you want to read the number of requests arrived during the most recent window of T seconds, first drop from the "old" end of the queue those timestamps that are older than T seconds, then read the size of the queue. You should also drop elements whenever you add a new request to the queue to keep its size bounded (assuming bounded rate for incoming requests). This solution works up to arbitrary precision, e.g. millisecond accuracy. If you are content with returning approximate answers, you can e.g. for time window of T = 3600 (an hour), consolidate requests coming within same second into a single queue element, making queue size bounded by 3600. I think that would be more than fine, but theoretically loses accuracy. For T = 1, you can do consolidation on millisecond level if you want. In pseudocode: queue Q proc requestReceived() Q.insertAtFront(now()) collectGarbage() proc collectGarbage() limit = now() - T while (! Q.empty() && Q.lastElement() < limit) Q.popLast() proc count() collectGarbage() return Q.size() A: Why not just use a circular array? We have 3600 elements in that array. index = 0; Array[index % 3600] = count_in_one_second. ++index; if you want last second, return the last element of this array. if you want last minute, return the sum of last 60 elements. if you want last hour, return the sum of the whole array (3600 elements). Isn't his a simple and effective solution? Thanks Deryk

2024-04-14T01:27:04.277712

https://example.com/article/9632

Cameron Britton Cameron Britton (born June 6, 1986) is an American actor known for his role as Ed Kemper in the Netflix crime drama television series Mindhunter, for which he received a Primetime Emmy Award nomination for Outstanding Guest Actor in a Drama Series, and Hazel in the Netflix television series The Umbrella Academy. Career Britton previously worked as a preschool teacher for eight years, where he taught special needs children ranging from 18 months to 3 years old. Britton had his breakout role as Ed Kemper in the 2017 Netflix crime drama Mindhunter. He played hacker Plague in the 2018 crime thriller film The Girl in the Spider's Web. In the Netflix TV show The Umbrella Academy, he played the role of Hazel, a time-travelling assassin. Filmography Film Television References External links Category:Living people Category:American actors Category:1986 births Category:21st-century American male actors

2024-07-11T01:27:04.277712

https://example.com/article/3882

Q: Determine the vaues $p$ such that the following series converge? Let $a_{n}\geq 0$ and $\sum_{1}^{\infty}a_{n}$ be a convergent series. Determine the values $p$ such that $\sum_{1}^{\infty}\frac{\sqrt{a_{n}}}{n^{p}}$ converge? A: Hint: $(1)$ Use the Schwarz Inequality, $x_i=\sqrt{a_i}$, $y_i=\frac{1}{i^p}$ to show that there is convergence if $p\gt \frac{1}{2}$. $(2)$ Show we cannot do better by using $a_n =\frac{1}{n\log^a n}$ for suitable $a$.

2024-02-03T01:27:04.277712

https://example.com/article/6869

from the about-time dept One of my biggest complaints about the way some old school journalism folks view "the news business," is that they still have trouble recognizing they're in the community business. They're so focused on delivering the "news," they forget the bigger issue. The news business has always been a community business. It was a way of bringing together a community of people with something in common (usually locality), and then selling their attention to advertisers. The big problem facing the industry today is that there are many more ways for communities to form. They used to be one of the few games in town. These days, however, there are many, many more places for communities -- and most of them treat the communities much better, and provide a lot more value. And yet, too often we hear newspaper folks talk down to and insult the idea that they should ever be expected to actually rub virtual shoulders with their community. They don't like using comments. They don't want to talk to fans or critics alike. They just want to report the news and move on. Obviously, there are many, many exceptions to this. And the number of exceptions are growing and that's a good thing, because eventually they won't be exceptions at all. For now, though, it's nice to highlight stories of journalists recognizing the importance of actually communicating with their community. Pickle Monger points us to a piece by a long-time BBC reporter, Paul Reynolds, talking about his experience embracing the community rather than shunning it, and recognizing that this involvement of the public really is "the future of news." He admits it wasn't always pleasant, and it did require establishing something of a thick skin, but he seems to feel that it's worth it. from the ownership-culture dept When you go around preaching the concept that ideas can be "owned," you're just asking for a lawsuit when you then ask people to voluntarily submit their own ideas. At some point, the Travel Channel put up a website, asking viewers for ideas for new shows. I'm sort of surprised they would do this, seeing as they must have known what would happen next. Some guy submitted an idea that probably a dozen or more people submitted: do a reality show on a family driving around the country in an RV. And, when the Travel Channel, along with NBC and the BBC announced a show called "The Great American Road Trip," the guy Christopher Cardillo insisted it was his idea that was being taken unfairly. So he sued for both copyright infringement and racketeering. Of course, you can't copyright ideas and Cardillo had never actually registered the copyright on the proposal itself anyway, so there was no copyright claim. And, now the court has also tossed out the ridiculous racketeering charge. The idea that setting up a website to solicit show ideas is akin racketeering seems to be a bigger stretch than even some of the most ridiculous lawsuits we see on a daily basis. While it's good that the court dismissed this, I'm amazed at a few things. First, on the copyright issue, the court notes "plaintiffs' failure to register their idea is fatal to their copyright claim." But, um, shouldn't the court know that you can't copyright an idea? While it gets the results right, the reasoning is weird. Similarly, on the racketeering issue, the court spends a lot of time focusing on how there's no pattern of racketeering from a single incident, but it's not clear that there was even a single incident that is in any way illegal. The idea of doing a reality show of people traveling in RVs around the country is hardly unique, and the actual show is quite different than what Cardillo proposed anyway (his involved just his family driving from the US to South America -- the real show involves a bunch of families around the country involved in a contest). Still, in the end, it's surprising that in a TV industry made up of folks who keep insisting that ideas can be "owned," that anyone would ever bother to put up a website asking for show ideas, and not expect to get sued. from the hello-ben-collins dept The incredibly popular UK BBC TV show Top Gear has been involved in a legal fight with publisher HarperCollins over the plans to publish a book revealing the identity of "The Stig," the always secretive test driver who appears in the show unidentified in a racing suit and helmet. The BBC spent its (publicly-funded) money to try to prevent such a revelation, but the UK courts have pointed out the basic free speech rights involved, and allowed racecar driver Ben Collins to admit that he's The Stig and have his autobiography published. Of course, in watching this battle unfold, I was confused as to why the BBC was going after HarperCollins, rather than targeting Ben Collins directly (and, by the way, I'm assuming the "Collins" in both names is a coincidence). Either way, as HarperCollins notes, this does appear to be a victory for free speech. In the meantime, if the BBC is really so upset that "the mystery" is gone, why not just get a new once-again secret Stig? In fact, the BBC has actually done exactly that in the past, dumping Perry McCarthy as the original Stig after his identity was revealed. from the something's-missing dept THREsq has an interesting story about how the guy, Louie Psihoyos, who won an Oscar for best documentary this year for The Cove, apparently has a pretty quick legal trigger finger against anyone using a photograph he took 15 years ago. He's sued a bunch of companies over the years, and the latest is the BBC and CBS. He claims that it cost him $100,000 to create the photograph, which can be seen here: And, yes, THREsq is showing the photo as well. In these two cases, it seems like clear fair use, since we're both reporting on the photo itself. However, where the BBC potentially got into trouble is in using the same photo to illustrate an article about Intel betting on TV and video content. What's odd, however, is that the reason CBS is being sued is "that CBS Marketing appropriated it for commercial display at the 2009 Intel Developers Forum." This makes me wonder if CBS Marketing used the image at the event that the BBC was reporting on, leading the BBC to believe it had the ability to use that image. That could make the legal fight a bit more interesting. However, the article also notes that Psihoyos has sued a bunch of times in the past over this photo as well. For example, a year ago, he sued Apple for the second time over this photo. While that lawsuit was eventually settled, the details suggest that Psihoyos was barking up the wrong tree on that lawsuit. It wasn't a case of Apple using the image, but a random iPhone app developer. You would think that Apple would have a clear DMCA safe harbor response, which would protect it from such a lawsuit, so I'm a bit surprised they ended up settling. from the lame dept Following on the US FCC's decision to let Hollywood add some DRM to movies it broadcasts to television, it looks like UK regulators Ofcom have gone even further in allowing the BBC to similarly use a form of DRM to try to stop copying of HD programming. Not surprisingly, this also came at the request of the entertainment industry. But, again, this seems to be about breaking what your technology allows, just so that the entertainment industry can have the illusion of control. The reports all say things like "This will allow broadcasters to stop piracy of shows," but that's patently ridiculous. There are always ways around these blocks for those who really want to get there -- and those shows will still end up online just as quickly (or maybe a few seconds later). And at that point, the locks are meaningless... except to folks who didn't want to have to buy an expensive locked down settop box that is required to view this kind of content. It's an incredibly anti-consumer move that has little to no benefit to the entertainment industry, other than in their minds. from the off-to-the-website dept Back in February, we noted that UK newspapers (the same ones who are blocking aggregators and putting up paywalls) were getting angry that the BBC was going to release an iPhone app. Their complaint was that it was somehow unfair, since the BBC is publicly funded, even though all it was really doing was taking its website and formating it better for the iPhone. Unfortunately, it looks like the BBC has agreed to put the whole thing on hold while it explores the issue. This is really unfortunate. At the same time that UK newspapers are locking up their content, they're trying to force others to do the same as well. Of course, they don't seem to realize that this won't help them any. It certainly won't help their business model. As for the BBC... well, it'll be a bit more annoying, but I imagine most folks who want their BBC content will quickly open a browser and go straight to the website. But they won't suddenly agree to pay Rupert Murdoch to access his news. from the how-refreshing dept We're so used to websites whose "link policies" are about what they want you to do to link to them, combined with the tendency for traditional media players to hate the external link, as if it were some sign of failure, that when someone anonymously submitted a link to the BBC News' "link policies," you'll have to forgive me for expecting the worst. Instead, the link policies were a bit of a revelation. They're all about how to link more to other sources. It all starts with a goal of sending more traffic elsewhere: The BBC Strategy Review [1.40MB PDF] recently unveiled by director general Mark Thompson set as one of its goals a major increase in outbound links from the BBC website - a doubling of the number of "click-throughs" to external sites from 10 million to 20 million a month by 2013. It then goes into a list of specific policies, which pretty much all focus on adding lots of external links to stories. Of course, given how UK newspapers are suddenly working hard to block links from others, you have to wonder if those same papers are going to start blocking the BBC as well... from the artificial-scarcity dept It's really amazing sometimes to see the entitlement mentality of newspapers -- who for years built business models on the fact that there was a scarcity of news sources out there. Now that they're finally facing real competition, rather than adapt, many seem to whine and ask the government to step in for them. Over in the UK, news publications have long been upset about the BBC, since its funded by the public, and they've been known to complain about competition from the BBC for years. So it's no surprise that they're demanding the BBC's new iPhone app be blocked. They claim that the app "will undermine the commercial sector's ability to establish an economic model in an emerging but potentially important market ... This, over the long term, will reduce members' ability to invest in quality journalism." Really? So the newspapers are basically admitting they're too clueless to compete in the marketplace? Sure, the BBC is publicly funded, but it's just one publication out there. Certainly newspapers can create their own services that attract an audience that competes with what the BBC is offering (or is focused on areas the BBC won't do). This is basically newspapers admitting they're too lazy to compete. Technically, the newspapers are complaining that this is a "new service" that needs approval, but the BBC correctly points out that all it did was create an app out of its existing web content. from the just-wondering... dept Over the last few months we've been hearing all these claims about how various "aggregators" and internet sites that simply rewrite articles from "mainstream" publications are somehow "parasites." But, of course, that ignores the fact that many of those mainstream publications do the exact same thing themselves. So, for example, earlier this week, there was a cute AP article getting passed around about a girl by the name of Kelly Hildebrandt who was bored one night and looked on Facebook for anyone else with her name, and found that the only other one was actually a guy. One thing led to another, and now they're getting married to each other (awwwww.) Anyway, not long after that, I saw that the BBC appears to have a very similar article, and it's quite clear that all they did was rewrite the AP's article. At one point, they do credit the AP, but the article is almost a direct paraphrase of the AP's. So does the AP start calling the BBC a parasite, too? Or does it finally realize that no one owns the news, and lots of publications often rewrite the news and have for ages? from the wrong-target dept It had seemed like perhaps The Guardian newspaper in the UK understood how the internet worked. After all, execs there had been saying that they hoped the NYTimes would start charging, since it would just drive a lot more traffic their way. However, it seems like not everyone at The Guardian is on the same page. Similar to Feargal Sharkey's call demand that the UK government investigate Google for not giving the recording industry money, The Guardian is now asking the UK government to investigate Google over its Google News product, specifically claiming that Google gets too much benefit from its content. Of course, there's a simple solution to this: take your news off of Google News (or take it offline altogether). But The Guardian doesn't want to do that. The reasoning is a bit convoluted, but, basically The Guardian says that since the online ad market is tough right now, it can't make enough money on the traffic that Google sends it. So stop accepting traffic from Google, right? No, it can't do that, because then competitors like the BBC would sweep up all of the traffic. Is it just me, or does this reasoning suggest that The Guardian should be asking the government not to investigate Google News, but the BBC for representing unfair competition? The Guardian's reasoning here is a bit tortured. It seems to be saying it can't compete with other sources due to Google News... even though those other sources have the exact same issue (getting traffic from Google News). It's only real complaint is that the BBC offers its content for free online -- and (though it doesn't appear to explicitly call this out), the BBC is publicly funded and doesn't have to focus on ad revenue like The Guardian does. So why isn't the complaint against the BBC instead of Google News? The Guardian always struck me as a pretty good paper, but the logic here is hard to understand. If it doesn't want the traffic, fine, don't take it (though, most people recognize that would be a mistake). If the problem is that it can't monetize the content effectively, then that's a business model problem for The Guardian -- not Google News. Finally, if the problem is (as it appears) competition from the BBC, then take it up with the BBC or those who fund it, but don't misplace the blame on Google News.

2024-04-13T01:27:04.277712

https://example.com/article/2362

Summers are usually tough for cars as the heat can destroy batteries and put a strain on the cooling systems. In order to prevent this, vehicle components should be checked frequently during summer to avoid [...]

2023-10-30T01:27:04.277712

https://example.com/article/3174

Postoperative pain control following arthroscopic release of adhesive capsulitis: a short-term retrospective review study of the use of an intra-articular pain catheter. The purpose of this study was to examine the effectiveness of an arthroscopically placed intra-articular pain catheter for controlling postoperative pain and also review the results following arthroscopic release of refractor adhesive capsulitis. Retrospective clinical trial. Twenty-three consecutive cases (20 patients) of arthroscopic adhesive capsulitis release in which an intra-articular pain catheter was used were reviewed. Follow-up ranged from 12 to 37 months (average, 22.4 months). An intra-articular catheter was placed under direct arthroscopic visualization from a superior approach into the glenohumeral joint. Postoperatively, patients were injected with 10 mL of 0.5% bupivacaine every 6 hours as needed. Preoperatively, all patients had filled out a questionnaire based on the American Shoulder and Elbow Surgeons (ASES) outcome guidelines and examined for range of motion. Postoperatively, patients were asked for their precatheter and postcatheter injection pain level based on the visual analog scale (1 to 10 points, 1 = no pain). Patients were then examined for range of motion and retested with the outcome questionnaire. An ASES Shoulder Score Index was calculated for each patient before and after the procedure. The average forward elevation preoperatively was 102 degrees and external rotation at the side was 4.5 degrees. At most recent follow-up, average forward elevation was 169 degrees with external rotation at the side 47 degrees. The Shoulder Score Index increased from an average of 37.1 out of 100 to 90.9 (P <.001). Before being injected with anesthetic through the catheter, patients had an average visual analog scale score of 8.1. Postinjection average pain level was 1.2 (P <.001) and all patients indicated that the pain catheter significantly reduced postoperative pain. Nineteen of 20 patients were satisfied with the procedure. Placement of an intra-articular pain catheter for delivery of bupivacaine was highly effective in controlling postoperative pain. In all cases, postoperative pain was essentially eliminated and this substantially assisted with range of motion exercises. Near complete restoration of range of motion without pain was achieved in 95% of the patients.

2023-10-03T01:27:04.277712

https://example.com/article/5646

sterile Parnis Submariner "homage" with ETA movement - real or not? hi all, I am looking into purchasing a Parnis Submariner with what is advertised as a ETA 2836 movement. However, I have read from many very reliable sources that Swatch has essentially shut down sales of all ETA movements to manufacturers that are not within the swatch group. So, my question is, how do I really know if I am really getting a genuine ETA movement, or if it is a equivalent Seagull movement with a greatly inflated price? I would hate to purchase the watch and have to remove the caseback to really validate, and if the movement is not a genuine ETA movement, fight for a refund. I don't think Swatch would sell their movements to Chinese watch makers... especially one that uses "cloned" movements on their catalogued models, like PARNIS. Able to share the advertisement you saw that claims "ETA Movement used"? I saw these on eBay the other day, and it's really hard to say because there are no pictures of the movement of the watch. (I'm assuming this is the watch you're talking about) If there were photos of the movement it'd be much easier to make a judgement on the validity of the movement. However, seeing as how they're starting their auction at $.99 I'm going to say not real, and that I've been conned my Chinese sellers selling watches that sound too good to be true. So I would be leery of these sellers. Firstly ETA has not stopped sale of movements. They just stopped selling ebauches, and stop selling at discounted prices to other manufacturers. You can still source ETA movements however you just pay retail price. Chances are high that it is a fake 2836-2. Helenarou's pictures should be checked out to see if they are real ETA or not. Firstly ETA has not stopped sale of movements. They just stopped selling ebauches, and stop selling at discounted prices to other manufacturers. You can still source ETA movements however you just pay retail price. Chances are high that it is a fake 2836-2. Helenarou's pictures should be checked out to see if they are real ETA or not. So, it seems that the consensus so far is that anything that is represented as a genuine ETA movement has a high probabilty of being a fake? I want to be very clear and say that I have nothing against buying a watch with a Seagull movement (I am wearing a 1963 re-issue right now). I do have a slight problem with buying something in good faith that turns out to be a fake :). Maybe I should just forgo any watches that claim to have an ETA movement, just to be safe? So, it seems that the consensus so far is that anything that is represented as a genuine ETA movement has a high probabilty of being a fake? I want to be very clear and say that I have nothing against buying a watch with a Seagull movement (I am wearing a 1963 re-issue right now). I do have a slight problem with buying something in good faith that turns out to be a fake :). Maybe I should just forgo any watches that claim to have an ETA movement, just to be safe? Econdreras, There are many fake ETA movements made in China. Without someone from the forums buying one and posting pictures I cannot frankly say those are genuine. After all for all we know he may have ripped the pictures off from some place, so comparing pictures and claiming authenticity is out without a 3rd party member involved.

2024-06-10T01:27:04.277712

https://example.com/article/3577

Roles of Nrf2/HO-1 and HIF-1α/VEGF in lung tissue injury and repair following cerebral ischemia/reperfusion injury. Cerebral ischemia/reperfusion injury (CIRI) leads to injury in distant organs, most commonly the lungs, although limited studies have examined self-protective mechanisms during CIRI-induced lung injury. Here, we investigated self-protective mechanisms that attenuate stress-related injury and promote the angiogenetic repair of epithelial function during CIRI-induced lung injury by measuring nuclear factor erythroid-related factor 2 (Nrf2) and hypoxia-inducible factor-1α (HIF-1α) levels. A CIRI model was established in male Sprague-Dawley rats by blocking the middle cerebral artery. Rats were divided into five subgroups based on the reperfusion time (6, 12, 24, 48, and 72 hr). Lung injury was assessed using a semiquantitative score and a thiobarbituric acid-based method of determining malonaldehyde production. Lung tissue angiogenesis was detected by CD34 and CD31 immunolabeling. Changes in Nrf2, heme oxygenase-1 (HO-1), HIF-1α, vascular-endothelial growth factor (VEGF), phosphatidylinositol 3-kinase (PI3K), extracellular-regulated kinase1/2 (ERK1/2), and phospho-ERK1/2 ( p-ERK1/2) protein- and mRNA-expression levels were measured by immunohistochemistry and reverse transcription polymerase chain reactions, respectively. Oxidative stress induced by cerebral ischemia/reperfusion (CI/R) caused lung injury. Expression of the Nrf2/HO-1 antioxidative stress pathway in lung tissues increased following CI/R, peaking after 24 hr. PI3K, ERK, and p-ERK1/2, which act upstream of Nrf2/HO-1, were expressed at higher levels in the CI/R-model group, consistent with the general trends observed for Nrf2/HO-1. Within 72 hr post-CI/R, HIF-1α, and VEGF expression significantly increased versus the sham group. Thus, during CIRI-induced lung injury, the body may upregulate antioxidative stress activities and promote angiogenesis to repair the endothelial barrier through the Nrf2/HO-1 and HIF-1α/VEGF signaling pathways, enabling self-protection.

2023-11-23T01:27:04.277712

https://example.com/article/5805

Conformational and configurational analysis of an N,N carbonyl dipyrrinone-derived oximate and nitrone by NMR and quantum chemical calculations. The geometries and relative energies of new N,N carbonyl dipyrrinone-derived oxime molecules (E/Z-s-cis 4a and E/Z-s-cis 4b) have been investigated. The calculated energies, molecular geometries, and (1) H/(13) C NMR chemical shifts agree with experimental data, and the results are presented herein. The E-s-cis conformations of 4a and 4b and the Z-s-cis conformation of 5b were found to be the thermodynamically most stable isomers with the oxime hydrogen atom or the methyl functional group adopting an anti-orientation with respect to the dipyrrinone group. This conformation was unambiguously supported by a number of 2D NMR experiments.

2024-06-22T01:27:04.277712

https://example.com/article/2111

This proposal?s objective is to develop and evaluate the microSPECT measurement of myocardial blood flow (MBF) in mice. MBF is a measure of microvasculature health and is an independent predictor of cardiovascular morbidity and mortality. Microvasculature dysfunction is often called coronary microvascular disease (CMVD) and has become an increasingly well-recognized cardiac pathology. Yet, despite mounting clinical evidence of its importance, there is a dearth of mechanistic understanding and targeted therapies for CMVD. The availability of numerous disease-based and genetic models and the ease of genetic manipulations makes the mouse model ideal for studying cardiovascular disease and its treatment. To develop non-invasive MBF measures in mice, we plan to consider 99mTc-labeled sestamibi and 201Tl as tracers; each has its own flow-dependent tracer extraction fraction (EXF), which can be species-specific. Thus, in Aim 1, we will map the relationship between radiotracer uptake, as measured by K1, and MBF for both tracers in normal mice. We will validate the use of microspheres as our gold-standard measure for MBF in mice by measuring the uncertainty of injections into the left-ventricle (LV) and left atrium (LA), where the latter is desirable for the more uniform mixing with blood before the microspheres are ejected from the LV, but is more technically challenging due to the small size of the LA and its thin wall. Similarly, we will use a dose calibrator to measure the tracer?s uptake concentration in the excised heart. With these gold standards for comparison, we will develop microSPECT MBF quantification on the MI Labs U-SPECT+ using a unique phantom and targeted animal studies to develop quantitative corrections and optimizations (Aim 2). This system can achieve resolution of ~0.35 mm with high sensitivity. The phantom will be used for studying the crosstalk relationship between uptake in the myocardium and the input function, as measured in the LV. We will optimize our dynamic fitting procedures using this phantom and determine appropriate quantitative corrections that account for spillover due to the system?s spatial resolution. This will be tested in our evaluations (Aim 3) where we will compare the longitudinal myocardial blood flow reserve (MBFR) in wild-type mice and transgenic mice in which the degree of microvascular dysfunction can be regulated. These longitudinal studies will be complemented with microsphere MBF and histological measures of capillary density. We expect the project?s outcomes to be: (1) microsphere MBF validation in mice and uncertainty determination; (2) EXF curves for sestamibi and 201Tl in normal mice; (3) determination of the better tracer for MBFR measurements in mice; (4) validation of that tracer?s EXF curve in a transgenic model; (5) development and validation of accurate in vivo MBF/MBFR measurements in mice; (6) validation of imaging-based MBF/MBFR decline in transgenic mice with gene activation; and (7) correlation of imaging and microsphere MBF/MBFR with capillary density. Developing this imaging technique in mice combined with a unique disease model that can be regulated will provide a powerful tool for research into coronary microvasculature disease.

2023-12-24T01:27:04.277712

https://example.com/article/4294

<table class="table table-bordered" style="table-layout: fixed;"> <thead> <tr> <th>Owner</th> <th>Rule</th> <th>Hexdump</th> </tr> </thead> <tbody> {% for row in analysis.memory.yarascan.data|volsort %} <tr> <td class="{{ row.class_ }}">{{row.owner}}</td> <td class="{{ row.class_ }}">{{row.rule}}</td> <td class="{{ row.class_ }}"><span class="mono"><pre>{{row.hexdump}}</pre></span></td> </tr> {% endfor %} </tbody> </table>

2023-09-24T01:27:04.277712

https://example.com/article/8753

Influence of host sex on the growth of a human glioblastoma line in athymic mice. Glioblastomas are generally thought to be more common in men than in women. In order to investigate the hormone-dependence of these tumours, we established a human glioblastoma line in athymic mice. The tumour cell type was characterized using immunocytochemical methods. The influence of host sex on growth was evaluated, and hormone receptors were characterized biochemically. The histological features of the initial tumour were conserved in the hetero-transplanted tumours, which consisted of vimentin and GFAP immunoreactive astrocytes. There was a highly significant difference in tumour growth between the two sexes (P less than 0.01). In the male mice, tumours were from 2.5 to 10 times larger than in the females, the latency periods were 30% shorter, and the growth phases were characterized by periods of slow or zero growth. In addition, androgen and oestrogen receptors were detected at low levels (80-270 fmol/g tumour) in the heterotransplanted tumours especially in the males. The fact that the male tumour growth profiles resembled those of some hormone-dependent lines, and that androgen receptors were found preferentially in the male rather than in female tumours would tend to indicate that there is a hormonal influence on the growth of the heterotransplanted tumours. These results provide further evidence for an influence of sex-steroid hormones on the growth of glioblastomas.

2024-04-17T01:27:04.277712

https://example.com/article/4319

The question of whether new market rate housing hurts or helps housing affordability—central to so many urban planning debates in the contemporary United States—can be answered with several new sources of data, according to an article by Emily Badger. The tension between these views sits at the center of battles over individual buildings and broader fights over how to alleviate the housing crisis. And until recently, there has been almost no data at the neighborhood scale to resolve it. It’s even plausible that both stories could be true at the same time — that new housing might help lower rents across a metro area even as it signals the popularity of a particular neighborhood and nudges up rents nearby. Several new studies finally offer some evidence that is encouraging, if incomplete. Researchers at N.Y.U., the Upjohn Institute and the University of Minnesota have all looked at what happens immediately surrounding new large-scale apartments that are market-rate (no rent restrictions). Many studies already show that regions that build more are more affordable (and regions that restrict new housing are less so). These latest studies ask if that pattern holds when we zoom in to individual blocks.

2023-10-24T01:27:04.277712

https://example.com/article/6931

Southern Lehigh tops Bethlehem Catholic in four sets When you match up two schools that have won the District 11 Class 2A girls volleyball championship for the last five years, and in the last four years they have played each other in the final, and these same two schools have played five-set matches every time they've played over the last three years, you know it's going to be a great night of volleyball. The only difference this time was that it only went to four sets, with Southern Lehigh, now a 3A school, beating Bethlehem Catholic, 25-20, 25-14, 20-25, 25-17. "I love coming here," Solehi coach Don West Jr. said. "I think it lost some of its luster because we aren't going to see each other again. This is usually at the beginning of the year and then we play again at the end of the year. But when you have the players we have here — they're loaded top to bottom, we're loaded top to bottom — and the girls love playing each other, it's great." The Spartans (2-0) won the first set, 25-20. It was closer than the score indicated as the Golden Hawks (3-1) never gave in. Solehi won the second set as well, by a surprisingly easy 25-14 score. Melann Amory had four of her team-high 13 kills in the set, while Jillian Grammer added a pair. Since these matches traditionally go to five sets, it was no surprise that Becahi won the third set, 25-20. Except for early in the set, the Hawks led the whole way. Lauren Hess registered six kills for the Hawks, while Morgan Keim added five, including the set winner. "Lauren's a phenomenal passer," West added. "We wanted to keep the ball off of Lauren because I think she's a great player." "It was really intense," Hess said. "Everyone was putting everything they had out on the court. Everyone gave 110 percent and we were really tired." The Spartans ran off the first four points of the fourth set and looked as if they were off to the races. But nothing is ever set in stone with these two teams. The Hawks fought back and, fittingly, Hess tied the score at 14 with a kill. She wears number 14, and after the kill went to the service line where she had an ace for Becahi's first lead in the set. A Solehi net violation gave Becahi a 16-13 lead, but Amory had a kill and Jenna Forrester had a pair of aces to start an eight-point run for the Spartans that put the game away. "That was kind of demoralizing," Hess said. "They kind of got in our heads a lot. We're not a head-case team but we kind of get shaken up at times. They got us." "I was just trying to stay calm and collect myself so that I didn't overshoot it and miss my serves," Forrester said of her run. "First we were playing real well, but we kind of let up in the third set," Amory said. "After playing so close in the first and us winning by a lot in the second, they probably thought, 'Hey, what's going on?' and they came back with fire. We just weren't ready for it. We came back in the fourth, but it was all as a team. It was not just one person." "We gave it all we had," Becahi coach Paul Abi-Daher said. "The girls did exactly what I wanted them to do. They played very hard. Southern Lehigh is a very good team. They have a solid defense and their defense beat us. They beat our offense, really. I'm very happy with how hard they played and we look forward to playing Central Catholic on Tuesday."

2024-05-12T01:27:04.277712

https://example.com/article/6082

Look for injuries and attitude problems to eat away at the Blazers’ optimism of recent years. What happened here? Just two years ago, the Blazers were optimism personified- young, talented, united and exceedingly likable. This was a team on the rise, inexperienced and nagged by the occasional injury, but without question a contender in the Western Conference for the better part of the next decade. In the 24 months that have followed, this appears to have evaporated. The incredibly likability? A casualty of infighting. The injuries that had previously been mere nuisances now derail seasons. First, there was $21 million free agent PG Andre Miller, signed in the summer of 2008. A starter for all but one game before joining Portland, Miller immediately clashed with coach Nate McMillan about his role on the team and has reportedly had a tough time meshing with incumbent superstar and face of the franchise, Brandon Roy. The duo hasn’t exactly meshed on the floor, with Miller only at his best when Roy’s been out with an injury. Both players need to dominate the ball in order to be effective, and the latest chapter of this mini-drama, Brandon Roy’s laid down the law. Meanwhile there’s Rudy Fernandez. Oh Rudy! The wheels on this one came flying off quickly. Upon entering the NBA in 2008, Rudy became an immediate favorite of fans across the league (I wanted more Rudy in my life!). Abe to score from anywhere on the floor, he was a spark plug of the bench and a key contributor as a rookie. His 159 3-pointers in 2008-09 were a record for a rookie. Last season he struggled with injuries and became increasingly unhappy with his role on the team and team’s walk-it-up style. His shooting numbers slipped considerably, from both sides of the 3-point line, and he was simply awful in thee Blazers first-round playoff loss to the Phoenix Suns, averaging just 6.8 ppg and failing to make an impact on the series. The arrival of Wesley Matthews likely signals the beginning of the end for Rudy in Portland. And this would be just fine by him, as he has shown a desire to traded and was fined $25,000 by the league after his agent said that Rudy might not to report to training camp. Given his ineffective play in 2009-10, the subsequent deterioration in his attitude and his public desire to blow town (thanks for torching your trade value Rudy!), look for Rudy to be shipped out of town in the coming weeks. And then there’s the first pick in the 2007 draft, Greg Oden. The big man chosen ahead of Kevin Durant (oof!) who’s suited up for just one out of every three (82 of 246) Blazers’ games since he was drafted. Last December, just days after establishing career-highs in points (24) and rebounds (20) and looking like a lock to become one of the NBA’s most dominant rebounders and shotblockers, he suffered his most recent catastrophic blow, as a fractured patella ended his season. On Monday, 10 months after the injury, Oden participated in 5-on-5 drills for the first time. After his workout, he said that there’s no definite timetable for his return, but Oden and the club (and fans as well, not just the ones in Portland) are hoping for a late-November/early-December return. However, anyone buying into this timetable may want to take out insurance. On those rare occasions when he’s healthy and able to log significant floor time, Oden actually looks really good. Prior to his latest injury, Oden looked great in the paint with 11.1 points, 8.4 rebounds and 2.3 blocks in 21 starts and was becoming increasingly comfortable with the flow of the NBA game, and his role in it. One would assume that Oden’s return to the floor will restore much of the lost optimism from recent years. And while his return will be cheered by fans across the NBA, even when everything seems to be going swimmingly, there will always be a lingering fear in the back of every Blazer fan’s mind. A fear that it could all end on play. Not good for optimism. Bottom line: Vegas has the over-under on regular seasons wins for the Blazers at 51.5. This number appears to be rather optimistic given the lack of reliable depth in the middle (Oden and Joel Przybilla missed 113 games last season and Camby’s played 70+ game just four times in his career), instability in the backcourt (Miller-Roy, Rudy’s meltdown impending exit and the need to integrate Wesley Matthews) and a total lack of rebounding outside of the center position. Not only is this team unlikely to win 52+ games in 2010-11, they could miss the number by 10 or ore wins and will finish no better than #8 in the West.

2023-10-21T01:27:04.277712

https://example.com/article/7858

Hesketh’s new deal, which will run until 2021, sees him extend his commitment to the club he has been at since the age of eight. The 20 year-old, who made his Saints debut in December 2014, is currently working his way back from an injury suffered in October. Hesketh enjoyed a memorable start to his season, scoring his first ever Southampton goal in a 2-0 win against Crystal Palace in the EFL Cup. The midfielder then featured in the UEFA Europa League, as he made a big impression on manager Claude Puel. Speaking about his new contract, Hesketh said: “It’s a really good feeling. With a new manager coming in going into the last year of my contract I knew I had to hit the ground running to do my best to impress him. “I got a couple of opportunities and this is a nice reward for it, so it’s something I’m really happy about. “I don’t think there was any doubt in my mind that this is the place to be for young players.” Jake Hesketh outside the Markus Liebherr Pavilion Executive Director of Football Les Reed said: “We’re delighted to see Jake extend his commitment to the football club. “After making his debut, Jake worked extremely hard to get himself back into the first-team squad, and we were all delighted when he scored his first goal for the club at St Mary’s earlier this season. “Having been with the club since the age of eight, Jake’s development has been an excellent example of the club’s philosophy, seeing Academy graduates given the opportunity in the first team. “Following on from Sam McQueen and Harrison Reed, we’re delighted that our Academy graduates see Southampton as the perfect environment to continue their development.” Related Reed signs new Saints contract

2024-05-29T01:27:04.277712

https://example.com/article/5085

/*------------------------------------------------------------------------------ 16.0 - Themes ------------------------------------------------------------------------------*/ /*------------------------------------------------------------------------------ 16.1 - Manage Themes ------------------------------------------------------------------------------*/ .theme-browser .themes { clear: both; padding: 0 0 100px; } .themes-php .wrap h2 { float: left; margin-bottom: 15px; } .network-admin.themes-php .wrap h2 { margin-bottom: 0; } .themes-php .wrap h2 .button { margin-left: 20px; } /* Search form */ .themes-php .wp-filter-search { position: relative; top: -2px; left: 20px; margin: 0; width: 280px; font-size: 16px; font-weight: 300; line-height: 1.5; } /* Position admin messages */ .themes-php div.updated, .themes-php div.error { margin: 0 0 20px 0; clear: both; } .themes-php div.updated a { text-decoration: underline; } /** * Main theme element * (has flexible margins) */ .theme-browser .theme { cursor: pointer; float: left; margin: 0 4% 4% 0; position: relative; width: 30.6%; border: 1px solid #dedede; -webkit-box-shadow: 0 1px 1px -1px rgba(0,0,0,0.1); box-shadow: 0 1px 1px -1px rgba(0,0,0,0.1); -webkit-box-sizing: border-box; -moz-box-sizing: border-box; box-sizing: border-box; } .ie8 .theme-browser .theme { width: 30%; margin: 0 3% 4% 0; } .theme-browser .theme:nth-child(3n) { margin-right: 0; } .theme-browser .theme:hover, .theme-browser .theme:focus { cursor: pointer; } .theme-browser .theme .theme-name { font-size: 15px; font-weight: 600; height: 18px; margin: 0; padding: 15px; -webkit-box-shadow: inset 0 1px 0 rgba(0,0,0,0.1); box-shadow: inset 0 1px 0 rgba(0,0,0,0.1); overflow: hidden; white-space: nowrap; text-overflow: ellipsis; background: #fff; background: rgba(255,255,255,0.65); } /* Activate and Customize buttons, shown on hover and focus */ .theme-browser .theme .theme-actions { -ms-filter: "progid:DXImageTransform.Microsoft.Alpha(Opacity=0)"; opacity: 0; -webkit-transition: opacity 0.1s ease-in-out; transition: opacity 0.1s ease-in-out; position: absolute; bottom: 0; right: 0; height: 38px; padding: 9px 10px 0 10px; background: rgba(244, 244, 244, 0.7); border-left: 1px solid rgba(0,0,0,0.05); } .theme-browser .theme:hover .theme-actions, .theme-browser .theme.focus .theme-actions, .theme-browser .theme:focus .theme-actions { -ms-filter: "progid:DXImageTransform.Microsoft.Alpha(Opacity=100)"; opacity: 1; } .theme-browser .theme .theme-actions .button-primary { margin-right: 3px; } .theme-browser .theme .theme-actions .button-secondary { float: none; margin-left: 3px; } /** * Theme Screenshot * * Has a fixed aspect ratio of 1.5 to 1 regardless of screenshot size * It is also responsive. */ .theme-browser .theme .theme-screenshot { display: block; overflow: hidden; position: relative; -webkit-transition: opacity 0.2s ease-in-out; transition: opacity 0.2s ease-in-out; } .theme-browser .theme .theme-screenshot:after { content: ''; display: block; padding-top: 66.66666%; /* using a 3/2 aspect ratio */ } .theme-browser .theme .theme-screenshot img { height: auto; position: absolute; left: 0; top: 0; width: 100%; -webkit-transform: translateZ( 0 ); /* Prevents rendering bugs in Chrome */ -webkit-transition: opacity 0.2s ease-in-out; /* Prevents rendering bugs in Chrome */ transition: opacity 0.2s ease-in-out; } .theme-browser .theme:hover .theme-screenshot, .theme-browser .theme:focus .theme-screenshot { background: #fff; } .theme-browser.rendered .theme:hover .theme-screenshot img, .theme-browser.rendered .theme:focus .theme-screenshot img { opacity: 0.4; } .theme-browser .theme .more-details { -ms-filter: "progid:DXImageTransform.Microsoft.Alpha(Opacity=0)"; opacity: 0; position: absolute; top: 35%; right: 25%; left: 25%; background: #222; background: rgba(0,0,0,0.7); color: #fff; font-size: 15px; text-shadow: 0 1px 0 rgba(0,0,0,0.6); -webkit-font-smoothing: antialiased; font-weight: 600; padding: 15px 12px; text-align: center; -webkit-border-radius: 3px; border-radius: 3px; -webkit-transition: opacity 0.1s ease-in-out; transition: opacity 0.1s ease-in-out; } .theme-browser .theme:focus { border-color: #5b9dd9; -webkit-box-shadow: 0 0 2px rgba( 30, 140, 190, 0.8 ); box-shadow: 0 0 2px rgba( 30, 140, 190, 0.8 ); } .theme-browser .theme:focus .more-details { opacity: 1; } /* Current theme needs to have its action always on view */ .theme-browser .theme.active:focus .theme-actions { display: block; } .theme-browser.rendered .theme:hover .more-details, .theme-browser.rendered .theme:focus .more-details { -ms-filter: "progid:DXImageTransform.Microsoft.Alpha(Opacity=100)"; opacity: 1; } /** * Displays a theme update notice * when an update is available. */ .theme-browser .theme .theme-update, .theme-browser .theme .theme-installed { background: #d54e21; background: rgba(213, 78, 33, 0.95); color: #fff; display: block; font-size: 13px; font-weight: 400; height: 48px; line-height: 48px; padding: 0 10px; position: absolute; top: 0; right: 0; left: 0; border-bottom: 1px solid rgba(0,0,0,0.25); overflow: hidden; } .theme-browser .theme .theme-update:before, .theme-browser .theme .theme-installed:before { content: '\f463'; display: inline-block; font: normal 20px/1 'dashicons'; margin: 0 6px 0 0; opacity: 0.8; position: relative; top: 5px; speak: none; -webkit-font-smoothing: antialiased; } /** * The currently active theme */ .theme-browser .theme.active .theme-name { background: #2f2f2f; color: #fff; padding-right: 110px; font-weight: 300; -webkit-box-shadow: inset 0 1px 1px rgba(0,0,0,0.5); box-shadow: inset 0 1px 1px rgba(0,0,0,0.5); } .theme-browser .theme.active .theme-name span { font-weight: 600; } .theme-browser .theme.active .theme-actions { background: rgba(49,49,49,0.7); border-left: none; opacity: 1; } .theme-browser .theme.active .theme-actions .button-primary { margin-right: 0; } .theme-browser .theme .theme-author { background: #222; color: #eee; display: none; font-size: 14px; margin: 0 10px; padding: 5px 10px; position: absolute; bottom: 56px; } .theme-browser .theme.display-author .theme-author { display: block; } .theme-browser .theme.display-author .theme-author a { color: inherit; text-decoration: none; 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font: normal 74px/115px 'dashicons'; width: 100px; height: 100px; vertical-align: middle; text-align: center; color: rgb(153, 153, 153); position: absolute; top: 30%; left: 50%; margin-left: -50px; text-indent: -4px; padding: 0; text-shadow: none; z-index:4; } .rtl .theme-browser .theme.add-new-theme span:after { text-indent: 4px; } .theme-browser .theme.add-new-theme:hover .theme-screenshot, .theme-browser .theme.add-new-theme:focus .theme-screenshot { background: none; } .theme-browser .theme.add-new-theme:hover span:after, .theme-browser .theme.add-new-theme:focus span:after { background: #fff; color: #0074a2; } .theme-browser .theme.add-new-theme:hover:after, .theme-browser .theme.add-new-theme:focus:after { border-color: transparent; color: #fff; background: #0074a2; content: ''; } .theme-browser .theme.add-new-theme .theme-name { background: none; text-align: center; -webkit-box-shadow: none; box-shadow: none; font-weight: 400; position: relative; top: 0; margin-top: -10%; margin-bottom: 10%; } .theme-browser .theme.add-new-theme:hover .theme-name, .theme-browser .theme.add-new-theme:focus .theme-name { color: #fff; z-index: 2; } /** * Theme Overlay * Shown when clicking a theme */ .theme-overlay .theme-backdrop { position: absolute; left: -20px; right: 0; top: 0; bottom: 0; background: #f1f1f1; background: rgba( 238, 238, 238, 0.9 ); z-index: 10; } .theme-overlay .theme-header { position: absolute; top: 0; left: 0; right: 0; height: 48px; border-bottom: 1px solid #ddd; } .theme-overlay .theme-header .close { cursor: pointer; height: 48px; width: 50px; text-align: center; float: right; border: 0; border-left: 1px solid #ddd; background-color: transparent; -webkit-transition: color .1s ease-in-out, background .1s ease-in-out; transition: color .1s ease-in-out, background .1s ease-in-out; } .theme-overlay .theme-header .close:before { font: normal 22px/50px 'dashicons' !important; color: #777; display: inline-block; content: '\f335'; font-weight: 300; } /* Left and right navigation */ .theme-overlay .theme-header .right, .theme-overlay .theme-header .left { cursor: pointer; color: #777; background-color: transparent; height: 48px; width: 54px; float: left; text-align: center; border: 0; border-right: 1px solid #ddd; -webkit-transition: color .1s ease-in-out, background .1s ease-in-out; transition: color .1s ease-in-out, background .1s ease-in-out; } .theme-overlay .theme-header .close:focus, .theme-overlay .theme-header .close:hover, .theme-overlay .theme-header .right:focus, .theme-overlay .theme-header .right:hover, .theme-overlay .theme-header .left:focus, .theme-overlay .theme-header .left:hover { background: #ddd; border-color: #ccc; color: #000; } .theme-overlay .theme-header .close:focus:before, .theme-overlay .theme-header .close:hover:before { color: #000; } .theme-overlay .theme-header .close:focus, .theme-overlay .theme-header .right:focus, .theme-overlay .theme-header .left:focus { -webkit-box-shadow: none; box-shadow: none; outline: none; } .theme-overlay .theme-header .left.disabled, .theme-overlay .theme-header .right.disabled, .theme-overlay .theme-header .left.disabled:hover, .theme-overlay .theme-header .right.disabled:hover { color: #ccc; background: inherit; cursor: inherit; } .theme-overlay .theme-header .right:before, .theme-overlay .theme-header .left:before { font: normal 20px/50px 'dashicons' !important; display: inline; font-weight: 300; } .theme-overlay .theme-header .left:before, .rtl .theme-overlay .theme-header .right:before { content: '\f341'; } .theme-overlay .theme-header .right:before, .rtl .theme-overlay .theme-header .left:before { content: '\f345'; } .theme-overlay .theme-wrap { clear: both; position: fixed; top: 9%; left: 190px; right: 30px; bottom: 3%; background: #fff; -webkit-box-shadow: 0 1px 20px 5px rgba(0, 0, 0, 0.1); box-shadow: 0 1px 20px 5px rgba(0, 0, 0, 0.1); z-index: 20; -webkit-box-sizing: border-box; -moz-box-sizing: border-box; box-sizing: border-box; } .theme-overlay .theme-wrap:after { content: "."; display: block; height: 0; clear: both; visibility: hidden; } body.folded .theme-overlay .theme-wrap { left: 70px; } .theme-overlay .theme-about { position: absolute; top: 49px; bottom: 57px; left: 0; right: 0; overflow: auto; padding: 2% 4%; } .theme-overlay .theme-about:after { content: "."; display: block; height: 0; clear: both; visibility: hidden; } .theme-overlay .theme-actions { position: absolute; text-align: center; bottom: 0; left: 0; right: 0; padding: 10px 25px 5px; background: #f3f3f3; z-index: 30; -webkit-box-sizing: border-box; -moz-box-sizing: border-box; box-sizing: border-box; border-top: 1px solid #eee; } .ie8 .theme-overlay .theme-actions { border: 1px solid #eee; } .theme-overlay .theme-actions a { margin-right: 5px; margin-bottom: 5px; } /* Hide-if-customize for items we can't add classes to */ .customize-support .theme-overlay .theme-actions a[href="themes.php?page=custom-header"], .customize-support .theme-overlay .theme-actions a[href="themes.php?page=custom-background"] { display: none; } .broken-themes a.delete-theme, .theme-overlay .theme-actions .delete-theme { color: #a00; text-decoration: none; border-color: transparent; -webkit-box-shadow: none; box-shadow: none; background: transparent; } .theme-overlay .theme-actions .delete-theme { position: absolute; right: 10px; bottom: 5px; } .broken-themes a.delete-theme:hover, .broken-themes a.delete-theme:focus, .theme-overlay .theme-actions .delete-theme:hover, .theme-overlay .theme-actions .delete-theme:focus { background: #d54e21; color: #fff; border-color: #d54e21; } .theme-overlay .theme-actions .active-theme, .theme-overlay.active .theme-actions .inactive-theme { display: none; } .theme-overlay .theme-actions .inactive-theme, .theme-overlay.active .theme-actions .active-theme { display: block; } /** * Theme Screenshots gallery */ .theme-overlay .theme-screenshots { float: left; margin: 0 30px 0 0; width: 55%; max-width: 880px; text-align: center; } /* First screenshot, shown big */ .theme-overlay .screenshot { border: 1px solid #fff; -webkit-box-sizing: border-box; -moz-box-sizing: border-box; box-sizing: border-box; overflow: hidden; position: relative; -webkit-box-shadow: 0 0 0 1px rgba(0,0,0,0.2); box-shadow: 0 0 0 1px rgba(0,0,0,0.2); } .theme-overlay .screenshot:after { content: ''; display: block; padding-top: 75%; /* using a 4/3 aspect ratio */ } .theme-overlay .screenshot img { height: auto; position: absolute; left: 0; top: 0; width: 100%; } /* Handles old 300px screenshots */ .theme-overlay.small-screenshot .theme-screenshots { position: absolute; width: 302px; } .theme-overlay.small-screenshot .theme-info { margin-left: 350px; width: auto; } /* Other screenshots, shown small and square */ .theme-overlay .screenshot.thumb { background: #ccc; border: 1px solid #eee; float: none; display: inline-block; margin: 10px 5px 0; width: 140px; height: 80px; cursor: pointer; } .theme-overlay .screenshot.thumb:after { content: ''; display: block; padding-top: 100%; /* using a 1/1 aspect ratio */ } .theme-overlay .screenshot.thumb img { cursor: pointer; height: auto; position: absolute; left: 0; top: 0; width: 100%; height: auto; } .theme-overlay .screenshot.selected { background: transparent; border: 2px solid #2ea2cc; } .theme-overlay .screenshot.selected img { opacity: 0.8; } /* No screenshot placeholder */ .theme-browser .theme .theme-screenshot.blank, .theme-overlay .screenshot.blank { background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAgAAAAICAYAAADED76LAAAALElEQVQYGWO8d+/efwYkoKioiMRjYGBC4WHhUK6A8T8QIJt8//59ZC493AAAQssKpBK4F5AAAAAASUVORK5CYII=); } /** * Theme heading information */ .theme-overlay .theme-info { width: 40%; float: left; } .theme-overlay .current-label { background: #333; color: #fff; font-size: 11px; display: inline-block; padding: 2px 8px; -webkit-border-radius: 2px; border-radius: 2px; margin: 0 0 -10px; -webkit-user-select: none; -moz-user-select: none; -ms-user-select: none; user-select: none; } .theme-overlay .theme-name { color: #222; font-size: 32px; font-weight: 100; margin: 10px 0 0; line-height: 1.3; } .theme-overlay .theme-version { color: #999; font-size: 13px; font-weight: 400; float: none; display: inline-block; margin-left: 10px; -webkit-user-select: none; -moz-user-select: none; -ms-user-select: none; user-select: none; } .theme-overlay .theme-author { color: #686868; font-size: 16px; font-weight: 400; margin: 15px 0 25px; } .theme-overlay .theme-author a { text-decoration: none; } .theme-overlay .theme-description { color: #555; font-size: 15px; font-weight: 400; line-height: 1.5; margin: 30px 0 0 0; } .theme-overlay .theme-tags { border-top: 3px solid #eee; color: #888; font-size: 13px; font-weight: 400; margin: 30px 0 0 0; padding-top: 20px; } .theme-overlay .theme-tags span { color: #444; font-weight: bold; margin-right: 5px; } /* Theme Updates info */ .theme-overlay .theme-update-message { background: #fef7f1; border: 1px solid #eee; border-left: 4px solid #d54e21; -webkit-border-radius: 3px; border-radius: 3px; padding: 5px 20px 10px; } .theme-overlay .theme-update { color: #222; font-size: 18px; display: inline-block; line-height: 40px; margin: 0; } .theme-overlay .parent-theme { background: #f7fcfe; border: 1px solid #eee; border-left: 4px solid #2ea2cc; font-size: 14px; font-weight: normal; margin-top: 30px; padding: 10px 10px 10px 20px; } .theme-overlay .parent-theme strong { font-weight: 700; } /** * Single Theme Mode * Displays detailed view inline when a user has no switch capabilities */ .single-theme .theme-overlay .theme-backdrop, .single-theme .theme-overlay .theme-header, .single-theme .theme { display: none; } .single-theme .theme-overlay .theme-wrap { clear: both; min-height: 330px; position: relative; left: auto; right: auto; top: auto; bottom: auto; } .single-theme .theme-overlay .theme-about { padding: 30px 30px 70px; position: static; } .single-theme .theme-overlay .theme-actions { position: absolute; } /** * Basic Responsive structure... * * Shuffles theme columns around based on screen width */ @media only screen and (min-width: 2000px) { #wpwrap .theme-browser .theme { width: 17.6%; margin: 0 3% 3% 0; } #wpwrap .theme-browser .theme:nth-child(3n), #wpwrap .theme-browser .theme:nth-child(4n) { margin-right: 3%; } #wpwrap .theme-browser .theme:nth-child(5n) { margin-right: 0; } } @media only screen and (min-width: 1680px) { .theme-overlay .theme-wrap { width: 1450px; margin: 0 auto; } } /* Maximum screenshot width reaches 440px */ @media only screen and (min-width: 1640px) { .theme-browser .theme { width: 22.7%; margin: 0 3% 3% 0; } .theme-browser .theme .theme-screenshot:after { padding-top: 75%; /* using a 4/3 aspect ratio */ } .theme-browser .theme:nth-child(3n) { margin-right: 3%; } .theme-browser .theme:nth-child(4n) { margin-right: 0; } } /* Maximum screenshot width reaches 440px */ @media only screen and (max-width: 1120px) { .theme-browser .theme { width: 47.5%; margin-right: 0; } .theme-browser .theme:nth-child(even) { margin-right: 0; } .theme-browser .theme:nth-child(odd) { margin-right: 5%; } } /* Admin menu is folded */ @media only screen and (max-width: 900px) { .theme-overlay .theme-wrap { left: 65px; } } @media only screen and (max-width: 780px) { body.folded .theme-overlay .theme-wrap, .theme-overlay .theme-wrap { top: 0; /* The adminmenu isn't fixed on mobile, so this can use the full viewport height */ right: 0; bottom: 0; left: 0; padding: 70px 20px 20px; border: none; z-index: 500; /* should overlap #wpadminbar, which is 500 on mobile. */ position: fixed; } .theme-browser .theme.active .theme-name span { /* Hide the "Active: " label on smaller screens. */ display: none; } .theme-overlay .theme-screenshots { width: 40%; } .theme-overlay .theme-info { width: 50%; } .single-theme .theme-wrap { padding: 10px; } .theme-browser .theme .theme-actions { padding: 5px 10px 4px 10px; } .theme-overlay.small-screenshot .theme-screenshots { position: static; float: none; max-width: 302px; } .theme-overlay.small-screenshot .theme-info { margin-left: 0; width: auto; } .theme:not(.active):hover .theme-actions, .theme:not(.active):focus .theme-actions, .theme:hover .more-details, .theme:focus .more-details { display: none; } .theme-browser.rendered .theme:hover .theme-screenshot img, .theme-browser.rendered .theme:focus .theme-screenshot img { opacity: 1.0; } } @media only screen and (max-width: 480px) { .theme-browser .theme { width: 100%; margin-right: 0; } .theme-browser .theme:nth-child(2n), .theme-browser .theme:nth-child(3n) { margin-right: 0; } } @media only screen and (max-width: 650px) { .theme-overlay .theme-update, .theme-overlay .theme-description { margin-left: 0; } .theme-overlay .theme-actions .delete-theme { position: relative; right: auto; bottom: auto; } .theme-overlay .theme-actions .inactive-theme { display: inline; } .theme-overlay .theme-screenshots { width: 100%; float: none; } .theme-overlay .theme-info { width: 100%; } .theme-overlay .theme-author { margin: 5px 0 15px 0; } .theme-overlay .current-label { margin-top: 10px; font-size: 13px; } .themes-php .wrap h2 { width: 100%; } .themes-php .wp-filter-search { float: none; clear: both; left: 0; top: 0; right: 0; margin: 10px 0; width: 100%; max-width: 280px; } .theme-browser .theme.add-new-theme span:after { font: normal 60px/90px 'dashicons'; width: 80px; height: 80px; top: 30%; left: 50%; text-indent: 0; margin-left: -40px; } .single-theme .theme-wrap { margin: 0 -12px 0 -10px; padding: 10px; } .single-theme .theme-overlay .theme-about { padding: 10px; overflow: visible; } .single-theme .current-label { display: none; } .single-theme .theme-overlay .theme-actions { position: static; } } .broken-themes { clear: both; } .broken-themes table { text-align: left; width: 50%; border-spacing: 3px; padding: 3px; } /*------------------------------------------------------------------------------ 16.2 - Install Themes ------------------------------------------------------------------------------*/ /* Already installed theme */ .theme-browser .theme .theme-installed { background: #0074a2; } .theme-browser .theme .theme-installed:before { content: '\f147'; } .theme-browser .theme.is-installed .theme-actions .button-primary { display: none !important; } .theme-install-php a.upload, .theme-install-php a.browse-themes { cursor: pointer; } .theme-install-php a.browse-themes, .theme-install-php.show-upload-theme a.upload { display: none; } .theme-install-php.show-upload-theme a.browse-themes { display: inline; } .upload-theme, .upload-plugin { -webkit-box-sizing: border-box; -moz-box-sizing: border-box; box-sizing: border-box; display: none; margin: 0; padding: 0; width: 100%; overflow: hidden; position: relative; top: 10px; } body.show-upload-theme .upload-theme, .upload-plugin { display: block; } .upload-theme .wp-upload-form, .upload-plugin .wp-upload-form { background: #fafafa; border: 1px solid #e5e5e5; padding: 30px; margin: 30px auto; max-width: 380px; } .upload-theme .install-help, .upload-plugin .install-help { color: #999; font-size: 18px; font-style: normal; margin: 0; padding: 40px 0 0; text-align: center; } body.show-upload-theme .upload-theme + .wp-filter, body.show-upload-theme .upload-theme + .wp-filter + .theme-browser { display: none; } p.no-themes { color: #999; font-size: 18px; font-style: normal; margin: 0; padding: 0; text-align: center; display: none; } body.no-results p.no-themes { display: block; } body.show-upload-theme p.no-themes { display: none !important; } .theme-install-php .add-new-theme { display: none !important; } @media only screen and (max-width: 1120px) { .upload-theme .wp-upload-form { margin: 20px 0; max-width: 100%; } .upload-theme .install-help { font-size: 15px; padding: 20px 0 0; text-align: left; } } .rating { margin: 15px 0 0; } .rating span:before { color: #e6b800; content: "\f154"; display: inline-block; -webkit-font-smoothing: antialiased; font: normal 20px/1 'dashicons'; vertical-align: top; } /* Half stars */ .rating-10 span.one:before, .rating-30 span.two:before, .rating-50 span.three:before, .rating-70 span.four:before, .rating-90 span.five:before { content: "\f459"; } /* Full stars */ .rating-20 span.one:before { content: "\f155"; } .rating-30 span.one:before, .rating-40 span.one:before, .rating-40 span.two:before { content: "\f155"; } .rating-50 span.one:before, .rating-50 span.two:before, .rating-60 span.one:before, .rating-60 span.two:before, .rating-60 span.three:before { content: "\f155"; } .rating-70 span.one:before, .rating-70 span.two:before, .rating-70 span.three:before, .rating-80 span.one:before, .rating-80 span.two:before, .rating-80 span.three:before, .rating-80 span.four:before { content: "\f155"; } .rating-90 span.one:before, .rating-90 span.two:before, .rating-90 span.three:before, .rating-90 span.four:before, .rating-100 span.one:before, .rating-100 span.two:before, .rating-100 span.three:before, .rating-100 span.four:before, .rating-100 span.five:before { content: "\f155"; } .rating .ratings { display: block; line-height: 20px; color: #999; } /*------------------------------------------------------------------------------ 16.3 - Custom Header Screen ------------------------------------------------------------------------------*/ .appearance_page_custom-header #headimg { border: 1px solid #DFDFDF; overflow: hidden; width: 100%; } .appearance_page_custom-header #upload-form p label { font-size: 12px; } .appearance_page_custom-header .available-headers .default-header { float: left; margin: 0 20px 20px 0; } .appearance_page_custom-header .random-header { clear: both; margin: 0 20px 20px 0; vertical-align: middle; } .appearance_page_custom-header .available-headers label input, .appearance_page_custom-header .random-header label input { margin-right: 10px; } .appearance_page_custom-header .available-headers label img { vertical-align: middle; } /*------------------------------------------------------------------------------ 16.4 - Custom Background Screen ------------------------------------------------------------------------------*/ div#custom-background-image { min-height: 100px; border: 1px solid #dfdfdf; } div#custom-background-image img { max-width: 400px; max-height: 300px; } /*------------------------------------------------------------------------------ 23.0 - Full Overlay w/ Sidebar ------------------------------------------------------------------------------*/ body.full-overlay-active { overflow: hidden; } .wp-full-overlay { background: transparent; z-index: 500000; position: fixed; overflow: visible; top: 0; bottom: 0; left: 0; right: 0; height: 100%; min-width: 0; } .wp-full-overlay-sidebar { -webkit-box-sizing: border-box; -moz-box-sizing: border-box; box-sizing: border-box; position: fixed; width: 300px; height: 100%; top: 0; bottom: 0; left: 0; padding: 0; margin: 0; z-index: 10; background: #eee; border-right: none; } .wp-full-overlay.collapsed .wp-full-overlay-sidebar { overflow: visible; } .wp-full-overlay.collapsed, .wp-full-overlay.expanded .wp-full-overlay-sidebar { margin-left: 0 !important; } .wp-full-overlay.expanded { margin-left: 300px; } .wp-full-overlay.collapsed .wp-full-overlay-sidebar { margin-left: -300px; } .wp-full-overlay-sidebar:after { content: ''; display: block; position: absolute; top: 0; bottom: 0; right: 0; width: 3px; z-index: 1000; } .wp-full-overlay-main { position: absolute; left: 0; right: 0; top: 0; bottom: 0; height: 100%; } .wp-full-overlay-sidebar .wp-full-overlay-header { position: absolute; left: 0; right: 0; height: 45px; padding: 0 15px; line-height: 45px; z-index: 10; margin: 0; border-top: none; -webkit-box-shadow: none; box-shadow: none; } .wp-full-overlay-sidebar .wp-full-overlay-header a.back { margin-top: 9px; } .wp-full-overlay-sidebar .wp-full-overlay-footer { bottom: 0; border-bottom: none; border-top: none; -webkit-box-shadow: none; box-shadow: none; } .wp-full-overlay-sidebar .wp-full-overlay-sidebar-content { position: absolute; top: 45px; bottom: 45px; left: 0; right: 0; overflow: auto; } /* Close & Navigation Links */ .theme-install-overlay .wp-full-overlay-sidebar .wp-full-overlay-header { padding: 0; } .theme-install-overlay .close-full-overlay, .theme-install-overlay .previous-theme, .theme-install-overlay .next-theme { display: block; position: relative; float: left; width: 45px; height: 45px; padding-right: 2px; background: #eee; border-right: 1px solid #ddd; color: #444; cursor: pointer; text-decoration: none; -webkit-transition: color .1s ease-in-out, background .1s ease-in-out; transition: color .1s ease-in-out, background .1s ease-in-out; } .theme-install-overlay .close-full-overlay:hover, .theme-install-overlay .close-full-overlay:focus, .theme-install-overlay .previous-theme:hover, .theme-install-overlay .previous-theme:focus, .theme-install-overlay .next-theme:hover, .theme-install-overlay .next-theme:focus { background: #ddd; border-color: #ccc; color: #000; outline: none; -webkit-box-shadow: none; box-shadow: none; } .theme-install-overlay .close-full-overlay:before { font: normal 22px/1 dashicons; content: "\f335"; position: relative; top: 7px; left: 13px; } .theme-install-overlay .previous-theme:before { font: normal 20px/1 dashicons; content: "\f341"; position: relative; top: 6px; left: 14px; } .theme-install-overlay .next-theme:before { font: normal 20px/1 dashicons; content: "\f345"; position: relative; top: 6px; left: 13px; } .theme-install-overlay .previous-theme.disabled, .theme-install-overlay .next-theme.disabled, .theme-install-overlay .previous-theme.disabled:hover, .theme-install-overlay .previous-theme.disabled:focus, .theme-install-overlay .next-theme.disabled:hover, .theme-install-overlay .next-theme.disabled:focus { color: #bbb; background: #eee; cursor: default; pointer-events: none; } .rtl .theme-install-overlay .previous-theme:before { content: "\f345"; } .rtl .theme-install-overlay .next-theme:before { content: "\f341"; } /* Collapse Button */ .wp-full-overlay a.collapse-sidebar { position: absolute; bottom: 12px; left: 0; z-index: 50; display: block; width: 19px; height: 19px; margin-left: 15px; padding: 0; -webkit-border-radius: 50%; border-radius: 50%; color: #777; text-decoration: none; } .wp-full-overlay a.collapse-sidebar:hover { color: #0074a2; } .wp-full-overlay.collapsed .collapse-sidebar { position: absolute; left: 100%; } .wp-full-overlay .collapse-sidebar-arrow { position: static; margin-top: 0; margin-left: 0; display: block; width: auto; height: auto; background: none; } .wp-full-overlay .collapse-sidebar-arrow:before { -webkit-border-radius: 50%; border-radius: 50%; float: left; content: "\f148"; background: #eee; font: normal 20px/1 'dashicons'; speak: none; display: block; padding: 0; text-indent: 0; text-align: center; position: relative; -webkit-font-smoothing: antialiased; -moz-osx-font-smoothing: grayscale; text-decoration: none !important; } .wp-full-overlay.collapsed .collapse-sidebar-arrow:before, .rtl .wp-full-overlay .collapse-sidebar-arrow:before { -webkit-transform: rotate(180deg); -ms-transform: rotate(180deg); transform: rotate(180deg); } .rtl .wp-full-overlay.collapsed .collapse-sidebar-arrow:before { -webkit-transform: none; -ms-transform: none; transform: none; } .wp-full-overlay.collapsed .collapse-sidebar-arrow { background-position: -1px -109px; } .wp-full-overlay .collapse-sidebar-label { position: absolute; left: 100%; line-height: 20px; margin-left: 10px; } .wp-full-overlay.collapsed .collapse-sidebar-label { display: none; } /* Animations */ .wp-full-overlay, .wp-full-overlay-sidebar, .wp-full-overlay .collapse-sidebar, .wp-full-overlay-main { -webkit-transition-property: left, right, top, bottom, width, margin; transition-property: left, right, top, bottom, width, margin; -webkit-transition-duration: 0.2s; transition-duration: 0.2s; } /*------------------------------------------------------------------------------ 24.0 - Customize Loader ------------------------------------------------------------------------------*/ .no-customize-support .hide-if-no-customize, .customize-support .hide-if-customize, .no-customize-support.wp-core-ui .hide-if-no-customize, .no-customize-support .wp-core-ui .hide-if-no-customize, .customize-support.wp-core-ui .hide-if-customize, .customize-support .wp-core-ui .hide-if-customize { display: none; } #customize-container { display: none; background: #fff; z-index: 500000; position: fixed; overflow: visible; top: 0; bottom: 0; left: 0; right: 0; height: 100%; } .customize-active #customize-container { display: block; } .customize-loading #customize-container iframe { opacity: 0; } .customize-loading #customize-container { background: #fff url(../images/spinner.gif) no-repeat fixed center center; -webkit-background-size: 20px 20px; background-size: 20px 20px; } #customize-container iframe, .theme-install-overlay iframe { height: 100%; width: 100%; z-index: 20; -webkit-transition: opacity 0.3s; transition: opacity 0.3s; } #customize-container .collapse-sidebar { bottom: 16px; } #customize-controls { margin-top: 0; } .theme-install-overlay { display: none; } .theme-install-overlay.single-theme { display: block; } .install-theme-info { display: none; padding: 10px 20px 60px; } .single-theme .install-theme-info { padding-top: 15px; } .theme-install-overlay .install-theme-info { display: block; } .install-theme-info .theme-install { float: right; margin-top: 18px; } .install-theme-info .theme-name { font-size: 16px; line-height: 24px; margin-bottom: 0; margin-top: 0; } .install-theme-info .theme-screenshot { margin-top: 15px; width: 258px; border: 1px solid #ccc; } .install-theme-info .theme-details { overflow: hidden; } .theme-details .theme-version { margin: 15px 0; float: left; } .theme-details .star-rating { margin: 7px 0; float: right; } .theme-details .theme-description { float: left; color: #777; line-height: 20px; max-width: 100%; } .theme-install-overlay .wp-full-overlay-header .theme-install { float: right; margin: 8px 10px 0 0; /* For when .theme-install is a span rather than a.button-primary (already installed theme) */ line-height: 26px; } .theme-install-overlay .wp-full-overlay-sidebar { background: #eee; border-right: 1px solid #ddd; } .theme-install-overlay .wp-full-overlay-sidebar-content { background: #fff; border-top: 1px solid #ddd; border-bottom: 1px solid #ddd; } .theme-install-overlay .wp-full-overlay-main { background: #fff url(../images/spinner.gif) no-repeat center center; -webkit-background-size: 20px 20px; background-size: 20px 20px; } /* =Media Queries -------------------------------------------------------------- */ /** * HiDPI Displays */ @media print, (-o-min-device-pixel-ratio: 5/4), (-webkit-min-device-pixel-ratio: 1.25), (min-resolution: 120dpi) { .wp-full-overlay .collapse-sidebar-arrow { background-image: url(../images/arrows-2x.png); -webkit-background-size: 15px 123px; background-size: 15px 123px; } .customize-loading #customize-container, .theme-install-overlay .wp-full-overlay-main { background-image: url(../images/spinner-2x.gif); } .theme-install-overlay .wp-full-overlay-header .theme-install { margin-top: 2px; } } @media screen and ( max-width: 782px ) { .available-theme .action-links .delete-theme { float: none; margin: 0; padding: 0; clear: both; } .available-theme .action-links .delete-theme a { padding: 0; } .broken-themes table { width: 100%; } .theme-install-overlay .wp-full-overlay-header .theme-install { margin-top: 6px; line-height: normal; } }

2024-02-06T01:27:04.277712

https://example.com/article/1475

'Shark Tank': Teary tribute to firefighter dad yields $1 million (and counting) in orders Matthew Wilson | Special to USA TODAY Show Caption Hide Caption Watch kids of 9/11 cancer victim pitch his dream 'Shark Tank' product Three siblings pitch the sharks on the Cup Board Pro their dad, a New York City firefighter, dreamed up before his death. There wasn’t a dry eye in Sunday's "Shark Tank." Kaley, Christian and Keira Young may have wowed the sharks with their late father’s invention, but it’s the Young family’s story that broke their hearts. “It was his dream to pitch it on 'Shark Tank,' ” Kaley said of the Cup Board Pro, a chopping board with a detachable bowl for easy cleanup. “Unfortunately, he passed away before he had that chance, but we’re here today to continue his legacy and make that dream a reality.” And they did: Sony Pictures Television, which produces "Shark Tank," said Monday that within 18 hours, 26,000 Cup Board Pros had been back-ordered, worth more than $1 million in sales. Keith Young, seen briefly in a video demonstration of the product, was a New York City firefighter who assisted in cleanup at Ground Zero after the Sept. 11 terrorist attacks. He died three months before the “Tank” taping last May from cancer related to the 9/11 effort. The Cup Board Pro bears the insignia of all the firefighters who died in that tragedy. This especially resonated with guest shark Matt Higgins, an investor who also helped at Ground Zero. “I met a lot of brave people like your dad, and a lot of people lost their lives, so it’s great that you’re doing this.” But Keith was faced with another tragedy: The two-time champion on Food Network’s cooking series "Chopped" had to set aside his dream to take care of his dying wife. And the power of their story left several sharks, including Daymond John, teary-eyed. More: 'Shark Tank' exclusive: These are the 20 best-selling products ever featured on the show “As he was getting his first prototypes, our mom was diagnosed with breast cancer, and he put everything on hold to be at her side,” Kaley said. “On Aug. 22, 2012, God called our mom home, and our dad showed us what strength was in every moment he continued to show up for us, and in life in general. He was a true inspiration, like our mom." Now, the three entrepreneurs, ranging in age from 15 to 24, hope to honor their parents' legacy. They started an online store and are running the business out of their living room. “It’s kind of hard to overwhelm the three of us, because of the amount of stress you go through seeing a loved one sick,” Kaley said. “We’re only able to be here because of how strong our parents were.” And in a rare move, all five sharks – John, Higgins, Mark Cuban, Kevin O’Leary and Lori Greiner – came together to help: They jointly offered $100,000 for a 20 percent stake in the business, and promised to donate profits to a charity that helps firefighters affected on 9/11. “The story’s amazing,” Cuban said. “You have a million reasons to be proud. Your father will live on forever through each of you and his product.”

2023-12-17T01:27:04.277712

https://example.com/article/2756

Dramatic effect of heteroatom backbone substituents on the ethylene polymerization behavior of bis(imino)pyridine iron catalysts. Bis(imino)pyridine iron complexes bearing ether and thioether backbone substituents have been synthesized and evaluated for the polymerization of ethylene. The methoxy derivative is inactive whereas bulky phenoxides or thioether derivatives afford activities as high as the most active systems reported to date.

2024-07-22T01:27:04.277712

https://example.com/article/8444

--- abstract: 'The sub-micron range in the field of short distance interactions has yet to be opened to experimental investigation, and may well hold the key to understanding al least part of the dark matter puzzle. The *a*KWISP (*advanced*-KWISP) project introduces the novel Double Membrane Interaction Monitor (DMIM), a combined source-sensing device where interaction distances can be as short as 100 nm or even 10 nm, much below the $\approx 1-10$ $\mu$m distance which is the lower limit encountered by current experimental efforts. *a*KWISP builds on the technology and the results obtained with the KWISP opto-mechanical force sensor now searching at CAST for the direct coupling to matter of solar chameleons. It will reach the ultimate quantum-limited sensitivity by exploiting an array of technologies, including operation at milli-Kelvin temperatures. Recent suggestions point at short-distance interactions studies as intriguing possibilities for the detection of axions and of new physical phenomena.' author: - | [*G. Cantatore$^1$, V. Anastassopoulos$^{2}$, S. Cetin$^{3}$, H. Fischer$^{4}$, W. Funk$^{5}$, A Gardikiotis$^{2}$, D.H.H. Hoffmann$^{6}$, M. Karuza$^{7,1}$, Y.K. Semertzidis$^{8}$, D. Vitali$^{9}$, K. Zioutas$^{2,5}$*]{}\ $^1$University and INFN Trieste, Trieste, Italy\ $^2$University of Patras, Patras, Greece\ $^3$Bilgi University, Istanbul, Turkey\ $^4$University of Freiburg, Freiburg, Germany\ $^5$CERN, Geneva, Switzerland\ $^6$TU Darmstadt, Darmstadt, Germany\ $^7$University of Rijeka, Rijeka, Croatia\ $^8$CAPP, Daejeon, Korea\ $^9$University of Camerino, Camerino, Italy title: '*a*KWISP: investigating short-distance interactions at sub-micron scales' --- Introduction ============ Sensitive measurements on interactions at short separation distances between macroscopic bodies provide a window on physics beyond the Standard Model. In this field of study, interest focuses on Casimir-type interactions, including the topological Casimir effect which might lead to the detection of axions [@Zhitnitsky:2017], and on possible deviations from the standard gravitational interaction, modelled by a Yukawa-type potential representing the exchange of force carrier scalar particles [@Tkachev:1982; @Moody:1984]. These particles might be, for example, Dark Matter or Dark Energy candidates such as axions, moduli and chameleons, portals to extra-dimensions or dilatons. Each single one of these themes opens a view beyond the Standard Model. A key parameter is the distance scale at which the interaction is probed. Current experimental efforts reach distances of the order of 1-10 $\mu$m  [@Chen:2016] . Recently, even collider experiments such ATLAS at LHC reported probing extra-dimensions down to a distance of 11 $\mu$m [@ATLAS_note]. The original idea of *a*KWISP is building a novel opto-mechanical device consisting of two micro-membranes set a short distance apart, down to a few tens of nm. One of the two membranes (the “source” body) is excited in a controlled way by the radiation pressure of an amplitude-modulated laser beam. The displacements of the other membrane (the “sensing” body), possibly due to interactions with the source body, are then monitored by a Fabry-Perot interferometer at resonance with a second laser beam. Displacement sensitivities as low as $10^{-15} \ \mbox{m}/\sqrt{\mbox{Hz}}$ can be reached at room temperature [@Karuza:2016] thanks to the combination of two large quality factors, the finesse of the Fabry-Perot optical resonator $(\approx10^{5})$ and the figure of merit of the membrane mechanical resonator $(\approx10^{5})$. *a*KWISP enters the short-distance interaction field with the novel Double Membrane Interaction Monitor (DMIM) concept where interaction distances can be as short as 10 nm and plans to reach the ultimate quantum-limited sensitivity by achieving milli-Kelvin equivalent membrane temperatures with a combination of cryogenic and optical cooling [@Karuza:2012]. Figure \[Fig:PS\] shows an example of projected coverage by *a*KWISP in the parameter space of Yukawa-type corrections to the standard gravitational potential between two macroscopic bodies. $\alpha$ and $\lambda$ represent the interaction strength and range, respectively. This coverage is obtained when operating *a*KWISP at a temperature of 3 mK with thermally limited sensitivity and $10^5$ s integration time, corresponding to the detection of a force as feeble as $10^{-20}$ N. ![Projected *a*KWISP coverage in the parameter space of a Yukawa-type interaction between two macroscopic bodies. $\alpha$ and $\lambda$ represent the interaction strength and range, respectively. The black curve refers to a 1 $\mu$m separation distance between the two DMIM membranes, while the blue curve refers to a 100 nm one (see also text). The background plot is taken from [@Chen:2016].[]{data-label="Fig:PS"}](Giovanni_Cantatore_fig1.pdf){width="50.00000%"} The *a*KWISP experimental setup =============================== The *a*KWISP concept is based on the Double Membrane Interaction Monitor (DMIM) device. It consists of two thin (thickness $< 200$ nm) and taut $\mbox{Si}_{3}\mbox{N}_{4}$ membranes set parallel to each other at a distance which can be as short as 10 nm. Typical membrane dimensions are $5\cdot5 \ \mbox{mm}^{2}$. One of the two membranes is coated with an Al layer in order to be able to excite its oscillations in a controlled way by reflecting a laser beam off it, and in addition it has a 1 mm diameter hole at its center to allow free passage of a second laser beam which monitors the displacements of the second membrane. Both membranes have a 3 nm thick carbon conductive coating to allow setting them at a common electrical potential in order to reduce the effects of static charges. Figure \[Fig:DMIM\] shows a sketch of the DMIM device we have invented for *a*KWISP. A prototype set of suitable membranes for a DMIM has already been produced by Norcada Inc., Canada, and will be tested in the INFN Trieste optics laboratory. ![Sketch of the Double Membrane Interaction Monitor (DMIM) (see text).[]{data-label="Fig:DMIM"}](Giovanni_Cantatore_fig2.pdf){width="50.00000%"} In the *a*KWISP experimental apparatus, the DMIM is placed inside an optical Fabry-Perot interferometer kept at resonance, by means of an electro-optic active feedback [@Cantatore:1995], with a 1064 nm “sensing” laser beam. The Fabry-Perot is mounted inside a vacuum chamber to avoid noise due to the Brownian motion of air. ![Conceptual schematic of a possible *a*KWISP experimental setup (see text).[]{data-label="Fig:Setup"}](Giovanni_Cantatore_fig3.pdf){width="50.00000%"} Thanks to the hole in the source membrane, the sensing beam measures only the displacements of the sensing membrane: these modify the frequency of the standing optical wave resonating within the Fabry-Perot causing a detuning, which is then detected by the electro-optic feedback loop. This sensing scheme has already been demonstrated in [@Karuza:2016] where a single-membrane sensor has achieved a force sensitivity of $1.5\cdot10^{-14} \ \mbox{N}/\sqrt{\mbox{Hz}}$ ($7.5\cdot10^{-16} \ \mbox{m}/\sqrt{\mbox{Hz}}$ in terms of displacement) at room temperature. An opto-mechanical particle detector based on this principle, called KWISP, is now searching at CAST for the direct coupling to matter of solar chameleons [@KWISP:2014]. A second laser beam (“pump” beam), operating at a different wavelength (532 nm in our case) where the mirrors of the Fabry-Perot resonator are practically transparent, is used to excite oscillations in the source membrane by reflecting it off the Al coating. The frequency and amplitude of these oscillations can be controlled by a suitable amplitude modulation impressed on the pump beam. Figure \[Fig:Setup\] shows a schematic sketch of a possible setup for *a*KWISP. The ultimate sensitivity reachable with this class of opto-mechanical devices depends on temperature [@Lamoreaux:2008]. In order to reach equivalent temperatures in the milli-Kelvin range the DMIM could be inserted in the payload of a suitable cryostat/refrigerator and further cooled by means of optical cooling techniques [@Karuza:2012]. Perspectives ============ Highly sensitive measurements on short-distance interactions may uncover a host of hitherto unobserved physical processes, opening a window beyond the Standard Model. Among these, axions, moduli and chameleon particles, as well as portals towards extra dimensions and perhaps dilatons, may play a role. Casimir-type forces are also an open field of study when interaction distances range below 1 $\mu$m. Recently, the “topological” Casimir effect, which has never been observed, has been proposed as a tool to search for axions [@Zhitnitsky:2017]. The key parameter in all these investigations is the distance between the two interacting bodies, which must be less than 1 $\mu$m in order to open access to unexplored regions in parameter space (see Figure \[Fig:PS\]). The DMIM proposed here has the potential of lowering this distance to reach the 100 nm or perhaps even the 10 nm range. Using this device, the *advanced*-KWISP proposal presents a novel scheme to study sub-nuclear scale phenomena using a high sensitivity table-top opto-mechanical sensor based on precision technologies, such as micro-membranes and interferometric sensing coupled to cryogenic and optical cooling [99]{} C.J. Cao and A. Zhitnitsky, Phys. Rev. D  [**96**]{}, 015013 (2017). V.A. Kuz’min, I.I Tkachev, and M.E. Shaposhnikov, Pis’ma  Zh. Eksp. Theor. Fiz. [**36**]{}, 2, 49-52 (1982). J.E. Moody and F. Wilczek, Phys. Rev. D  [**30**]{}, 1 (1984). Y.-J. Chen *et al.*, Phys. Rev Lett. [**116**]{}, 221102 (2016). Private communication by C. is Clement, University of Stockholm, 2016; see also CERN PhD thesis from ATLAS group at `https://cds.cern.ch/record/2194414?ln=en`, page 192, and `arXiv:1604.07773`. M. Karuza, G. Cantatore, A. Gardikiotis, D.H.H. Hoffmann, Y.K. Semertzidis and K. Zioutas, Phys. Dark Univ. [**12**]{}, 100-104 (2016). M. Karuza *et al.*, New J. of Phys. [**14**]{}, 9, 095015 (2012). G. Cantatore *et al.*, Rev. Sc. Instr. [**66**]{}, 4, 2785-2787 (1995). S. Baum, G. Cantatore, D.H.H. Hoffmann, M. Karuza, Y.K. Semertzidis, A. Upadhye and K. Zioutas, Phys.  Lett.  B, [**739**]{}, 167-173 (2014); `http://cast.web.cern.ch/CAST/`; K. Zioutas, G. Cantatore and M. Karuza, “Cast: enlightening the dark”, CERN Courier, Jan.-Feb. 2016, p. 29. S. Lamoreaux, `arXiv:0808.4000`.

2024-04-26T01:27:04.277712

https://example.com/article/7488

At the Four Seasons Hotel - Livingston Room

2024-07-26T01:27:04.277712

https://example.com/article/3969

The health hazards associated with the smoking of combustible cigarettes, both to the smoker inhaling the smoke and to the non-smoker exposed to the second-hand smoke, have been well documented. For this reason, combustible cigarette smoking has increasingly become prohibited in many public places, such as restaurants, airplanes, airports, hospitals, shopping malls, the work place, etc., as well as socially unacceptable when a guest in a non-smoker's home. The social pressures to create a smoke-free society, while a boon to non-smokers, have made life rather unpleasant at times for habitual smokers finding themselves unable to satisfy their cigarette cravings. There are several factors which are known to contribute to the habitual smoker's cigarette cravings. These include the psychological factors of holding the cigarette, placing it between the user's lips, puffing on it, and experiencing the taste and aroma of the smoke, as well as the physiological factor of nicotine dependency. Combustible cigarettes satisfy the physiological needs of the smoker by releasing as a component of the cigarette smoke vaporous nicotine, which is inhaled into the user's lungs, becomes rapidly assimilated into the bloodstream, and reaches the brain via arterial systems. After crossing the blood-brain barrier, the nicotine finally binds to the nicotinic or cholinergic receptors to release adrenergic transmitters, such as epinephrine, norepinephrine and dopamine, which are generally associated with pleasure and reward. Because of the growing social unacceptability of combustible cigarette smoking, attempts have been made to provide cigarette substitute devices for non-pyrolytic use which simulate or closely approximate the look, feel and taste of combustible cigarettes and are capable of delivering nicotine vapor to the user through inhalation. Representative of those products are those described in the Ray U.S. Pat. No. 4,284,089, issued Aug. 18, 1981; the Hill U.S. Pat. No. 4,793,366, issued Dec. 27, 1988; and the Ray U.S. Pat. No. 4,813,437, issued Mar. 21, 1989. Such devices consist of an elongated tube having the approximate dimensions of an ordinary cigarette and housing a porous polymer plug serving as a reservoir for a source of vaporizable nicotine. The nicotine vapors are delivered to the user's lungs by the air drawn through the device by suction supplied by the user. These devices have failed to gain wide acceptance as a cigarette substitute, however, due to their inability to deliver sufficient and uniform amounts of nicotine to the user's lungs, an unpleasant taste, and an unsatisfactory shelf life. Most of these problems are due to the instability of the volatile liquid nicotine employed in these devices, which decomposes in the presence of oxygen and very rapidly dissipates from the system. Thus, there is a continuing need for an adequate substitute for combustible cigarette smoking which will satisfy both the psychological and physiological needs of the habitual smoker without offending the senses of his non-smoking neighbor.

2023-10-24T01:27:04.277712

https://example.com/article/4898

Risk of respiratory syncytial virus infection for infants from low-income families in relationship to age, sex, ethnic group, and maternal antibody level. The risk for hospitalization with respiratory syncytial virus infection during the first year of life was about five per 1,000 live births per year for infants born to low-income families in Houston from 1975 to 1979. The risk varied depending upon the intensity of the epidemic for a given season, the month of birth of the infant, and the level of passively acquired maternal antibody at the time of birth. Over 80% of the children hospitalized were less than 6 months of age; thus, most were born during the six months preceding the peak of RS virus activity. The neutralizing antibody titers in cord sera of 68 infants with culture-proven infections before 6 months of age were significantly lower than those of 575 randomly selected cord samples of infants born during the same period. The level of antibody at the time of birth was directly correlated with age at the time of infection. In addition, infants with more severe illnesses had lower levels of antibody in serum collected near onset of illness than did infants with milder illnesses. These observations demonstrate protection against RS infection in early infancy that is correlated with the level of maternal antibody, but it is not known if this protection is mediated directly by the passively acquired antibody or by some other mechanism.

2024-01-26T01:27:04.277712

https://example.com/article/6402

Brooklyn Decker Gossip I found this on Gawker today: BTS of a sex scene between Brooklyn Decker and Patrick Wilson (not a novice when it comes to sex scenes) directed by Joe Carnahan in the film Stretch. I’ve written before about how I’m super into movie sex when it’s done well. Full Story You like it? I don’t like it. Especially since his hair looked so good two weeks ago at CinemaCon - click here for a refresher. Here’s Taylor Kitsch, freshly buzzed, at the LA premiere of Battleship last night. Also attached - Alexander Skarsgard, Liam Neeson, and Brooklyn Decker who is getting completely out-styled by Rihanna every time they step out together. Full Story Taylor Kitsch was in Japan this weekend promoting both John Carter and Battleship. We went 4 for 5 last week on Taylor Kitsch photos and posts. Would it be too much to ask to be able to match it this week? Good start so far...As you can see, Alexander Skarsgard has now joined the Battleship cast on the promotional tour having missed a few stops. Full Story Taylor Kitsch photos were available 4 out of 5 days this week, a first for Taylor Kitsch. It’s easy of course since he’s currently in Europe promoting Battleship, stopping today in Spain with Brooklyn Decker and Peter Berg. Looks relaxed, doesn’t he? I like him so much in these shots. The more he does this, the more comfortable he’s becoming, the more his body language convinces me he believes (finally) that he belongs here. Full Story Sarah from Cinesnark says that John Carter might break even, eventually, but that it’s still considered a bust considering how much it cost to make and market it. Yes, John Carter took a massive dump. But there’s one good thing to have come from it: Taylor Kitsch gets papped now. Full Story Can we start the week off with some love for Riggs? Riggs has had it rough the last few weeks with the John Carter debacle which... is totally not his fault, and so he won’t be blamed for it, don’t worry. It’s time then, as you do in Hollywood, to shake that sh-t off and look to the next: Battleship. Full Story Youth is certainly potent but sometimes youth’s inexperience can lose one or two carpet battles. And this is how Jennifer Aniston’s little black dress beat out Brooklyn Decker’s horrific jumpsuit last night at the German premiere of Just Go With It or, as they refer to it over there, My Imaginary Wife. Full Story Housing market. You hear about this? Jennifer Aniston bought a house in Beverly Hills in 2006, after splitting from Brad Pitt, for $13 million. Then she spent 3 years redecorating. Now she’s listed it for $42 million. I suck at math, despite being Asian, so that’s, like, triple, right? Maybe it comes with a 5 year supply of weed, coke, and unlimited hugs. Full Story The famed Sports Illustrated Swimsuit Issue will be released next week. The much hyped cover will be announced Monday, specifically the lucky girl who has been chosen for it. Brooklyn Decker, currently costarring with Jennifer Aniston and Adam Sandler in Just Go With It, as her crazy ass body in a bikini dominates every trailer, is said to be the most likely candidate. Full Story

2024-06-12T01:27:04.277712

https://example.com/article/7798

492 F.2d 1237 U. S.v.Pineda-Marin 73-2158, 73-2159, 73-2197, 73-2319, 73-2639, 73-2647, 73-2650 UNITED STATES COURT OF APPEALS Second Circuit 3/7/74 1 E.D.N.Y. AFFIRMED

2024-05-28T01:27:04.277712

https://example.com/article/5668

Expression of metallothionein in initial and relapsed childhood acute lymphoblastic leukemia. In a retrospective study we analyzed the expression of metallothionein (MT) in initial acute lymphoblastic leukemia (ALL) of 92 children and in relapsed ALL of 27 children using immunohistochemistry. MT expression was detectable in 33% of the patients with initial ALL and in 33% of the patients with relapsed ALL. No differences were seen concerning the intensity and the proportion of positively stained cells between initial and relapsed patients. The expression of MT was independent of clinical prognostic factors such as age, sex, immunological subtype, and initial blast cell count. Patients with initial ALL and MT expression tended to have a lower probability of disease-free survival compared with the MT-negative group. The relapsed patients with MT expression showed also a trend toward a shorter survival in comparison to the MT-negative group. However, the differences were not statistically significant. Thus, the results show that MT expression is not an important prognostic factor in the clinical drug resistance of childhood All.

2023-11-20T01:27:04.277712

https://example.com/article/7973

Warrior Epic: Official Release True Games today announced the official launch date of its highly anticipated title Warrior Epic. The official launch date for North America is May 19th. “Our beta testers have given us a lot of great feedback and we are confident that the game is now reaching a point where we can provide the Warrior Epic community an engaging and compelling experience,” said Jeff Lujan, Founder and Chairman of True Games. True Games will continue to put Warrior Epic through rigorous beta testing through Monday, May 18th and are accepting a second round of closed beta testers to provide feedback before the official launch. Those who wish to partake in the closed beta will be rewarded through in-game events and promotions. Those interested in joining can register at www.warriorepic.com. Developed by Austin based studio Possibility Space, Warrior Epic is an online, action role-playing game set in an original fantasy universe. In the game, players will assume command of a Warrior Hall from which they manage their characters’ adventures. They can recruit from a wide array of Warrior Classes, each with its own style of play. The Classes and the Hall itself can be upgraded visually as well as functionally. One of the most unique aspects of Warrior Epic is that death does not mean the end of a warrior. Instead, it opens totally new and strategic options for players. The game’s unique Warrior Spirits System enables fallen warriors to not only be revived at any time at their hall, but also to be transformed into Spirits that can be bound to weapons to increase and open weapon abilities and skills, or they can be called out to inflict massive damage depending on player needs.

2024-07-08T01:27:04.277712

https://example.com/article/4260

The path to metastatic mouse models of colorectal cancer. The study and comprehension of the molecular mechanisms underlying cancer biology strongly rely on mouse modeling. An ideal mouse model should have molecular, histopathological, and etiological characteristics as close as possible to those of the corresponding human tumors. Among solid tumors, colorectal cancer (CRC) is one of the malignancies that best suits reproduction in an animal model: it evolves through a progressive set of molecular events and is generally associated with a precise histopathology and a neat cataloging of stages and grades. The development of refined CRC mouse models over several decades has seen them recently evolve toward sophisticated systems that ever more closely approximate the human pathology, with different models addressing different human CRC subtypes. In particular, a metastatic CRC model has been seen as a "holy grail" in this field, and we describe in this review the path taken to achieve metastatic models and discuss the path forward.

2024-05-01T01:27:04.277712

https://example.com/article/8779

Exercise Computing multiple aggregates of multiple columns The .agg() method can be used with a tuple or list of aggregations as input. When applying multiple aggregations on multiple columns, the aggregated DataFrame has a multi-level column index. In this exercise, you're going to group passengers on the Titanic by 'pclass' and aggregate the 'age' and 'fare' columns by the functions 'max' and 'median'. You'll then use multi-level selection to find the oldest passenger per class and the median fare price per class. The DataFrame has been pre-loaded as titanic. Instructions 100 XP Group titanic by 'pclass' and save the result as by_class. Select the 'age' and 'fare' columns from by_class and save the result as by_class_sub. Aggregate by_class_sub using 'max' and 'median'. You'll have to pass 'max' and 'median' in the form of a list to .agg(). Use .loc[] to print all of the rows and the column specification ('age','max'). This has been done for you. Use .loc[] to print all of the rows and the column specification ('fare','median').

2024-07-31T01:27:04.277712

https://example.com/article/1999

module.exports = function(hljs) { var OPENING_LONG_BRACKET = '\\[=*\\['; var CLOSING_LONG_BRACKET = '\\]=*\\]'; var LONG_BRACKETS = { begin: OPENING_LONG_BRACKET, end: CLOSING_LONG_BRACKET, contains: ['self'] }; var COMMENTS = [ hljs.COMMENT('--(?!' + OPENING_LONG_BRACKET + ')', '$'), hljs.COMMENT( '--' + OPENING_LONG_BRACKET, CLOSING_LONG_BRACKET, { contains: [LONG_BRACKETS], relevance: 10 } ) ]; return { lexemes: hljs.UNDERSCORE_IDENT_RE, keywords: { literal: "true false nil", keyword: "and break do else elseif end for goto if in local not or repeat return then until while", built_in: //Metatags and globals: '_G _ENV _VERSION __index __newindex __mode __call __metatable __tostring __len ' + '__gc __add __sub __mul __div __mod __pow __concat __unm __eq __lt __le assert ' + //Standard methods and properties: 'collectgarbage dofile error getfenv getmetatable ipairs load loadfile loadstring' + 'module next pairs pcall print rawequal rawget rawset require select setfenv' + 'setmetatable tonumber tostring type unpack xpcall arg self' + //Library methods and properties (one line per library): 'coroutine resume yield status wrap create running debug getupvalue ' + 'debug sethook getmetatable gethook setmetatable setlocal traceback setfenv getinfo setupvalue getlocal getregistry getfenv ' + 'io lines write close flush open output type read stderr stdin input stdout popen tmpfile ' + 'math log max acos huge ldexp pi cos tanh pow deg tan cosh sinh random randomseed frexp ceil floor rad abs sqrt modf asin min mod fmod log10 atan2 exp sin atan ' + 'os exit setlocale date getenv difftime remove time clock tmpname rename execute package preload loadlib loaded loaders cpath config path seeall ' + 'string sub upper len gfind rep find match char dump gmatch reverse byte format gsub lower ' + 'table setn insert getn foreachi maxn foreach concat sort remove' }, contains: COMMENTS.concat([ { className: 'function', beginKeywords: 'function', end: '\\)', contains: [ hljs.inherit(hljs.TITLE_MODE, {begin: '([_a-zA-Z]\\w*\\.)*([_a-zA-Z]\\w*:)?[_a-zA-Z]\\w*'}), { className: 'params', begin: '\\(', endsWithParent: true, contains: COMMENTS } ].concat(COMMENTS) }, hljs.C_NUMBER_MODE, hljs.APOS_STRING_MODE, hljs.QUOTE_STRING_MODE, { className: 'string', begin: OPENING_LONG_BRACKET, end: CLOSING_LONG_BRACKET, contains: [LONG_BRACKETS], relevance: 5 } ]) }; };

2024-05-04T01:27:04.277712

https://example.com/article/4078

Send this page to someone via email WATCH ABOVE: Officers cordoned off an industrial area around noon after receiving reports of a man with a gun. TORONTO/HALIFAX – Halifax Regional Police say there was no sign of a reported gunman at an industrial park in Dartmouth. Heavily armed police locked down the Burnside Industrial Park after receiving reports of a man with a gun just after 11:30 a.m. on Saturday. WATCH: Police lock down area in Dartmouth after gunman sighting Halifax Regional Police Sgt. Jeff Carr said a man called police to report a man with a gun on the roof of a business. Story continues below advertisement Carr said police have spoken with that witness several times to confirm the story. “He was very confident it was a long gun that the person was carrying. We responded with several police units. We originally had a large perimeter not knowing what we were dealing with,” he said. Police spent hours scouring the area but, just before 6 p.m. Atlantic time, confirmed that no gunman had been found and there was no evidence related to the report of a gunman. “The scene is contained. They’re confident there’s nobody in the building,” said Staff Sgt. Bill Morris. Morris said police seized a long gun and two pellet guns but they have yet to determine if the weapons were involved in the report of the gunman. Story continues below advertisement “There were no shots fired. We’re going to follow up on some eyewitness accounts that we had to determine what exactly happened here to bring us to this point,” Morris said. Morris adds that no one is in police custody in relation to the incident. Carr said other people nearby told police they had not seen a man with a gun. “Hopefully what this person believed they saw was not in fact the case,” he said. Police officers talk during an investigation into a report of a gunman in Halifax on Saturday, June 7, 2014. THE CANADIAN PRESS/Darren Pittman. Earlier police arrested and released two men; one man reportedly hopped a fence at the scene after hearing about the investigation on social media, and the other said he was working in the building and had not known about the evacuation. “I was told to stay inside until the officers came to get me,” said Ivan Hill. Story continues below advertisement “I just come out to the door and of course they handcuff me and told me to walk backwards, the whole scenario,” he said. “Now I’m all scared like everybody else.” READ MORE: Hundreds attend vigil for fallen RCMP officers No charges are expected against either men. People working in the building where the gunman was supposedly spotted describe a hectic scene. “The officers just [came up to us] and told us we have to evacuate,” said Freddy Croke. “They said that there were reports he was on the yellow building on the roof. Then they lost him from that point,” said Anna Isenor. “It is nerve-wracking after everything that’s been on the news the past couple days,” she said, referring to the shootings in Moncton. Story continues below advertisement The New Brunswick town is still mourning after three RCMP officers were shot to death and two others were wounded. Carr said the incident is still fresh on the minds of officers. “It has been a tense time in the last week in policing. What I can say is all times we take the utmost in relation to the safety of the public and also in relation to the safety of our officers,” he said. Global Halifax journalists Julia Wong and Cory McGraw reported live from the scene.

2023-11-12T01:27:04.277712

https://example.com/article/5184

This is the Golden Age of Television—not only as the blooming of lush and addictive entertainment, but also as an arms race for the best living-room technology. Just days after Amazon announced its new Fire TV box, the Verge snagged exclusive images of Google's new Android TV product. Both services let couch-potatoes pull up apps like Netflix, Hulu Plus, or Amazon Prime Video on their TV screens, basically turning the idiot box into a big, smart iPad. Weeks ago, the Wall Street Journal announced that Apple, which has sold about 25 million Apple TV "hockey pucks," is talking to Comcast about building a new streaming-TV service. Fire TV, Android TV, and Apple TV all have the word TV in them, so you might easily confuse them for old-fashioned TV. But they're not old-fashioned TV, at all. TV, as we know it, is cable packages and live channels. But the new players are building an Internet-video experience around apps with very little access to live television. It's not TV. It's Internet TV. Even as these tech upstarts are battling each other for living-room dominance, they're also battling the legacy of traditional television and the sturdy cable bundle. Here's the tale of the tape:

2024-02-27T01:27:04.277712

https://example.com/article/4464

Q: " echo" in bash script empty file I have problem with echo command I need export data to csv but its empty file #!/bin/bash while read domain do ownname= whois $domain | grep -A 1 -i "Administrative Contact:" |cut -d ":" -f 2 | sed 's/ //' | sed -e :a -e '$!N;s/ \n/,/;ta' echo -e "$ownname" >> test.csv done < dom.txt A: You need to use command substitution to store command's output in a shell variable: #!/bin/bash while read domain; do ownname=$(whois $domain | grep -A 1 -i "Administrative Contact:" |cut -d ":" -f 2 | sed 's/ //' | sed -e :a -e '$!N;s/ \n/,/;ta') echo -e "$ownname" >> test.csv done PS: I haven't tested all the piped commands.

2024-01-19T01:27:04.277712

https://example.com/article/9860

Contact If you want to order by telephone or use WhatsApp, contact Megan at 306-401-0318. Jeanette runs our head office in Mitchell, Manitoba. You can call her to arrange a time to shop for dresses at her house. P: 204-320-3042 cell: 204-380-1702 Mailing Address: Wear A Dress 126 Solomon Ave Mitchell, MB R5G 2M5 Appointments to try on a dress can be booked with Megan in Carrot River, Saskatchewan. P: 306-401-0318 Mailing Address: Wear A Dress Box 577 Carrot River, SK S0E 0L0 If you are not happy with your dress, please let us know immediately. You can return it for a refund and order another size or style. We want you to find a dress to suit you and make you feel attractive all day, every day. We are a new company positioned to respond to our customers’ needs.

2024-01-25T01:27:04.277712

https://example.com/article/5730

Q: profile-refresh in Fuse 6.2 does not reload snapshot bundle I am running JBoss Fuse 6.2.0. I built a small camel application that just writes to the log every 5 seconds. I built it and installed the SNAPSHOT bundle jar in my local Maven repository. In the Karaf console I did the following: fabric:profile-create --parent feature-camel logdemo fabric:profile-edit --bundle mvn:com.company.project/logdemo logdemo fabric:container-create-child --profile logdemo root child1 The camel application now worked as intended. I then made a small change to the application, rebuilt it and installed the new SNAPSHOT bundle jar in my local Maven repo. In the Karaf console I then did the following to get Karaf to load the new jar: fabric:profile-refresh logdemo But the loaded application is still the old version. How do I get Karaf to look for the updated jar in my local maven repo? It seems like it has some internal cache it looks in instead. Note: We're not using Maven to build the application, so all answers about using Maven plugins like the fabric8 plugin will be rejected. A: You should use the fabric:watch * command for that. This will update all containers that run a snapshot version of an artifact that is updated in the local maven repo. If you want only a specific container to watch for updates use dev:watch * on the shell of that container. See http://fabric8.io/gitbook/developer.html

2024-04-09T01:27:04.277712

https://example.com/article/1866

Q: Drop rows with repeating NaN values in Pandas beyond a threshold Is there a way to drop rows with NaN values only beyond a certain threshold for repetition? For example, let's say we want the threshold of consecutive rows to be four. The following example with six consecutive rows with NaN values would have all six rows dropped. start value 2018-03-11 09:00:00+00:00 0.8 2018-03-11 09:15:00+00:00 0.0 2018-03-11 09:30:00+00:00 NaN 2018-03-11 09:45:00+00:00 NaN 2018-03-11 10:00:00+00:00 NaN 2018-03-11 10:15:00+00:00 NaN 2018-03-11 10:30:00+00:00 NaN 2018-03-11 10:45:00+00:00 NaN 2018-03-11 11:00:00+00:00 1.0 2018-03-11 11:15:00+00:00 1.6 2018-03-11 11:30:00+00:00 0.8 But the following example would have no rows dropped. start value 2018-03-11 09:00:00+00:00 0.8 2018-03-11 09:15:00+00:00 0.0 2018-03-11 09:30:00+00:00 0.0 2018-03-11 09:45:00+00:00 0.8 2018-03-11 10:00:00+00:00 NaN 2018-03-11 10:15:00+00:00 NaN 2018-03-11 10:30:00+00:00 NaN 2018-03-11 10:45:00+00:00 NaN 2018-03-11 11:00:00+00:00 1.0 2018-03-11 11:15:00+00:00 1.6 2018-03-11 11:30:00+00:00 0.8 Thanks! A: Using diff with ne cumsum create the group key , then we doing the Boolean slice. n=4 s=df.value.isnull().groupby(df.value.isnull().astype(int).diff().ne(0).cumsum()).transform('count') df.loc[~((s>n)&(df.value.isnull()))] Out[69]: start value 0 2018-03-1109:00:00+00:00 0.8 1 2018-03-1109:15:00+00:00 0.0 8 2018-03-1111:00:00+00:00 1.0 9 2018-03-1111:15:00+00:00 1.6 10 2018-03-1111:30:00+00:00 0.8

2023-09-27T01:27:04.277712

https://example.com/article/4593

As featured on p. 218 of "Bloggers on the Bus," under the name "a MyDD blogger." Sunday, March 22, 2009 The Detainees In North Korea Just a quick word on this: it is exceedingly weird to me to know the subject of a major news story, and even weirder to know the subject of an international incident. Euna Lee is an editor I knew briefly when I lived in San Francisco, as we worked at the same place. She moved on to Current TV and was sent to China to film around the Tumen River border area with North Korea. North Korean authorities picked up her and her fellow journalist Laura Ling and have detained them for several days now, claiming that they entered DPRK territory. The latest reports put the two in Pyongyang, and the State Department has opened talks for their release. It is completely irresponsible of Current to send these two young women alone to a dangerous border region, particularly at a time when the North Korean government wants to test their limits with a new Administration. Current's whole "citizen journalist" model doesn't mean you airdrop citizens into difficult circumstances and essentially ask them to poke a bear with a stick. But at this point, we have to hope the State Department can extract their release. Give them a second of your thoughts if you can. I don't really know what else can be done, but if you have ideas, throw them in the comments.

2023-12-16T01:27:04.277712

https://example.com/article/6240

Canal 8 Honduras Televisión Nacional de Honduras (Spanish for: National Television of Honduras) or TNH is a state-owned television network based in Tegucigalpa, Honduras, which can be seen throughout the country on channel eight. It was illegally launched in August 2008 during the government of Manuel Zelaya when it was known as "Canal 8 - Red Informativa del Poder Ciudadano". After the events of June 28, 2009, the interim government has said it will shut down the channel since it was illegally operated. External links Canal 8 Honduras at LyngSat Address References Category:Television in Honduras Category:Spanish-language television stations Category:Television channels and stations established in 1962 Category:Media in Tegucigalpa

2024-04-03T01:27:04.277712

https://example.com/article/9886

Seasonal prevalence of gastrointestinal nematode parasites of sheep in Northern region of Nile Delta, Egypt. Over 1 year, from January to December 1999, a total of 173 slaughtered sheep at Al-Mahala abattoir were examined for presence of nematode parasites. Eighteen sheep (10.4%) were infected with eight different species of nematodes. The prevalence rates of detected nematode parasites were; Haemonchus contortus (3.5%), Haemonchus placei (1.7%), Trichuris ovis (5.8%), Parabronema skrjabini (2.9%), Ostertagia trifurcata (1.2%), Chabertia ovina (0.6%) and Strongyloides papillosus (0.6%), and Graphidiops species (2.9%). The seasonal prevalence of the infection with the nematode parasites was studied and the highest rate was during autumn (15.2%) followed by summer (11.1%) and winter (9.4%) while the lowest rate was during spring (5.6%).

2024-04-29T01:27:04.277712

https://example.com/article/7998

[The affective-behavioral orientations of teenagers with an unequal social status]. The study aims at establishing the affective-behavioral orientation in adolescents from the Homes for Children and Adolescents by examining their anxiety and readiness for aggression. In the investigation are included 227 children from 15 to 18 years old. The study is realized by using the questionnaire of Buss Durky for assessing the aggression, questionnaire for anxiety after Ch. Spilburgur and inquiry card for studying the problem of communication, directness of the personality etc. It is presumed that the unequivalant social conditions of life of adolescents from the Homes for Children and Adolescents have negative influence on the affective-behavioral orientation of the latter. We expect the raised aggressiveness to be with dominating hostile affective-cognitive orientation and in compliance with the high levels of uneasyness. The studying of predictors for emotional and behavioral derangements give us a possibility to reveal some subjective and social prerequisites, affecting the behavioral orientation and effective adaptation of juveniles from the Homes for Children and Adolescents.

2024-04-19T01:27:04.277712

https://example.com/article/6985

Q: building osmand with "ant debug" gives error I have checked out latest Osmand source code from here and followed all the steps from here now i am trying to build apk through ant with command ant debug but it fails i executed following commands : myname@myname-VirtualBox:~/dev/osmand/android/OsmAnd$ ant -f build.xml which gives output as BUILD SUCCESSFUL after when i try myname@myname-VirtualBox:~/dev/osmand/android/OsmAnd$ ant debug it fails with following log in the end : -crunch: [crunch] Crunching PNG Files in source dir: /home/moonshooter/dev/osmand/android/OsmAnd/res [crunch] To destination dir: /home/moonshooter/dev/osmand/android/OsmAnd/bin/res [crunch] Crunched 0 PNG files to update cache -package-resources: BUILD FAILED /home/myname/dev/osmand/android/OsmAnd/build.xml:27: The following error occurred while executing this line: /home/myname/dev/osmand/android/OsmAnd/build.xml:28: Missing attribute libraryRFileRefid Total time: 18 seconds the 27th and 28th lines in xml are <do-only-if-not-library elseText="Library project: do not package resources..."> <aapt executable="${aapt}" command="package" versioncode="${version.code}"versionname="${version.name}" debug="${build.is.packaging.debug}" manifest="${out.manifest.abs.file}"assets="${asset.absolute.dir}" androidjar="${project.target.android.jar}" apkfolder="${out.absolute.dir}"nocrunch="${build.packaging.nocrunch}" resourcefilename="${resource.package.file.name}"resourcefilter="${aapt.resource.filter}" libraryResFolderPathRefid="project.library.res.folder.path"libraryPackagesRefid="project.library.packages" previousBuildType="$`enter code here`{build.last.target}"buildType="${build.target}" ignoreAssets="${aapt.ignore.assets}"> and here is the whole file http://pastebin.com/Dv20iT8r Can any one tell me what is the problem? A: Just need to add this property libraryRFileRefid="project.library.bin.r.file.path" in aapt tag <do-only-if-not-library elseText="Library project: do not package resources..."> <aapt executable="${aapt}" command="package" versioncode="${version.code}" versionname="${version.name}" debug="${build.is.packaging.debug}" manifest="${out.manifest.abs.file}" assets="${asset.absolute.dir}" androidjar="${project.target.android.jar}" apkfolder="${out.absolute.dir}" nocrunch="${build.packaging.nocrunch}" resourcefilename="${resource.package.file.name}" resourcefilter="${aapt.resource.filter}" libraryRFileRefid="project.library.bin.r.file.path" libraryResFolderPathRefid="project.library.res.folder.path" libraryPackagesRefid="project.library.packages" previousBuildType="${build.last.target}" buildType="${build.target}" ignoreAssets="${aapt.ignore.assets}"> <res path="${out.res.absolute.dir}" /> <res path="${resource.absolute.dir}" /> <!-- <nocompress /> forces no compression on any files in assets or res/raw --> <!-- <nocompress extension="xml" /> forces no compression on specific file extensions in assets and res/raw --> </aapt> </do-only-if-not-library>

2024-05-16T01:27:04.277712

https://example.com/article/4378

Q: Allowing persons having sars-cov-2 antibodies to move freely Would it make sense from the public safety point of view to allow the persons already having the antibodies to move more freely than the persons not having the antibodies? Or it is more of an ethical question than a medical one? A: Projects for broad-based antibody blood tests are currently springing up like mushrooms. But the first test series available will be needed for the staff of health care. of course there are other interests for antibody tests: virological, epidemiological and as your question implies economical. Antibody blood tests should provide information about the spread of the corona virus so that the measures taken by the authorities can be adapted. A nationwide initiative is now putting pressure. https://www.sciencemag.org/news/2020/03/new-blood-tests-antibodies-could-show-true-scale-coronavirus-pandemic For example, if a selected group of people were tested for Sars-CoV-2 antibodies every two weeks, the course of the epidemic would be clearly visible. The interest, especially in business circles, is huge. Everyone urgently wanted to know where they were in the pandemic, who was at best already immune and could therefore probably move around and work safely again. https://www.srf.ch/news/schweiz/coronavirus-antikoerper-tests-ein-schweizweites-projekt-wird-aufgegleist Such data could inform practical issues such as whether and how to reopen schools that have been closed. Relatively few cases have been diagnosed among children, but it isn’t clear whether that’s because they don’t get infected or because their infections are generally so mild that they go unnoticed. Testing children for SARS-CoV-2 antibodies should resolve that. https://www.sciencemag.org/news/2020/03/new-blood-tests-antibodies-could-show-true-scale-coronavirus-pandemic Authorities are still afraid of a roll back of the wave when people start moving freely again. It must have a great acceptance and also be respected by those who should still stay at home.

2023-09-23T01:27:04.277712

https://example.com/article/8177

Overview Planetary Herbals - Kudzu Full Spectrum 750 mg. - 120 Tablets Code#:119765 Manufacturer:Planetary Herbals Size/Form:120 Tablets Packaged Ship Weight:0.30 Servings:60 Dosage Size:2 Tablet(S) Planetary Herbals - Kudzu Full Spectrum 750 mg. - 120 Tablets Planetary Herbals Kudzu Full Spectrum provides anti-alcohol support. The roots and flowers of the common kudzo (Pueraria lobata) have been used historically in China for anti-alcohol support. Planetary Herbals Full Spectrum Kudzu provides the roots, flowers, and a high potency standardized extract to deliver a full spectrum of kudzu's constituents and benefits. In China, kudzu is also used to support winter health and relax tightness and spasms of the neck and shoulders. Used traditionally in Chinese herbalism to safely treat the abuse of alcohol Combines a Full Spectrum blend of Kudzu's flowers and roots with a powerful root extract Naturally contains isoflavonoids and saponins that provide anti-alcohol support Supports the liver Helps the body's normal detoxification processes Provides traditionally recommended dosage You may have heard about kudzu lately. It's gotten a lot of mainstream attention due to a recent Harvard University study on the plant's ability to help decrease consumption of alcohol in human subjects. But that study, published in Alcoholism: Clinically and Experimental Research, only serves to demonstrate what Planetary Herbals and Chinese herbalism have long known, that kudzu is the premier herb for managing alcohol intake! And now, Planetary Herbals offers you two ways to take advantage of the time-tested benefits of this remarkable botanical: Full Spectrum Kudzu and Kudzu Recovery. Full Spectrum Kudzu provides the roots, flowers and a high potency standardized extract to deliver a Full Spectrum of kudzu's constituents and benefits. Additionally, Kudzu Recovery contains a centuries old Chinese formula offering all the benefits of kudzu plus key botanicals to support liver cleansing, balanced blood sugar levels and enhanced energy. Planetary Herbals offer the best of classic herbal traditions, integrating herbal formulas used continuously for thousands of years with the latest findings of clinical pharmacological research. History & UseKudzu is a fast growing evergreen vine native to parts of Asia, and an invasive species in much of the southeastern United States, where it was initially introduced to help fight soil erosion. First written about in 206 B.C., this unique botanical was popularized by macrobiotics proponents as a food thickener, and continues to be included in China's official pharmacopoeia. Although the entire plant is edible, kudzu's health supporting benefits come primarily from its flowers and roots, which contain several natural compounds including isoflavonoids and saponins. While the roots and flowers of the common kudzi have been used historically in Chinese herbalism for anti-alcohol support, it has also used to support winter health and relax tightness and spasms of the neck and shoulders and is a key component of Neck and Should Support by Planetary Herbals. Validated Through ResearchThough it's been used in Chinese herbalism to reduce abuse of alcohol for more than a millennium, it is only within the last decade that its actions in this respect have been scientifically examined. The latest research on effects were reported. Similar reductions in alcohol consumption have been observed in numerous pre-clinical studies. Full Spectrum KudzuFull Spectrum Kudzu offers you a Full Spectrum of the plant's beneficial constituents. Each dose of two tablets contains a highly concentrated standardized root extract delivering 40% isoflavones blended with a pure root and flower powder. Like all Full Spectrum products by Planetary Herbals, this provides the best in single ingredient products. FAQ DoesPlanetary Herbals have vegetarian products and if so which ones are they?Products that are for vegetarians have descriptions on the label that identify the specific product as vegetarian. If the label does not specify vegetarian, then the product may contain ingredients unsuitable for those specifically adhering to a vegetarian diet. I have allergies to various things and would like to know how to find out if Planetary Herbals products are hypoallergenic?Planetary Herbals declares the presence of any of the major food allergens. They also frequently describe on the label the specific components that the product does not contain to help you make a personal assessment of the suitability of the product for your specific allergic condition. Please check the label regularly, as some formulas change, as do allergens. You should always check with your healthcare professional before taking any dietary supplement if you have any health concerns. How does Planetary Herbals determine the "suggested use," "recommended dose," or "serving size," that are on the labels of your products?Each product is researched carefully by their product development and research team to determine the amount of product to be used that is both safe and effective. It is always important to read the label of the product in detail to clearly identify important usage information. If you have a specific dose or serving size concern, you should always check with your healthcare professional prior to utilizing any dietary supplement. Where do the ingredients for Planetary Herbals products come from?Their ingredients come from a variety of sources that are located all over the world and they must meet their strict requirements. Ingredients are sampled and inspected for both purity and potency. The specific locations or sources of their raw materials are proprietary to their business as many competitors attempt to reproduce their formulations. I am currently taking one of Planetary Herbals' dietary supplements. Can this item be mixed with other supplements?In many cases, though it varies for each individual's health needs, supplements can be combined. Of course, you should always read the labels of all the products you are considering to see if any contra-indications exist. Planetary Herbals highly recommends that you take personal responsibility for informing yourself to tailor your nutritional program to meet your own health goals. If you have a health question not clearly answered on the labels, consult with your healthcare professional. Is it safe for me to take Planetary Herbals dietary supplements if I have a specific medical problem?Planetary Herbals is in this business because they care about people's health. Anyone with a medical condition that has a concern about using a supplement product should always consult with their healthcare professional. About Planetary HerbalsPlanetary Herbals have been developed by expert herbalists, focusing predominantly on the thousands of years of experience of Ayurvedic and traditional Chinese herbalism, the hundreds of years of experience of Western herbal practitioners, and the more than 30 years of clinical experience of professional herbalists such as Michael Tierra, Lesley Tierra, Jill Stansbury, and Alan Tillotson. Planetary Herbals offers the best of classic herbal traditions, integrating herbal formulas used continuously for literally hundreds of thousands of years, with the latest finding of clinical pharmacological research. The Planetary Herbals philosophy encompasses much more than herbal magic bullets. Each product is designed to promote health, not just make people feel better. Planetary Herbals' Full Spectrum singles are designed to provide the best in single ingredient products; each formula is skillfully blended according to traditional and modern principles. Integral to this philosophy is attention to detail regarding quality of raw materials, individual responsibility for self-healing, environmental awareness, and education. Planetary Herbals' VisionThe majority of the world's population has relied upon plants for health and healing since the beginning of time. Planetary Herbals recognizes this and is committed to ensuring that their time-tested herbal traditions continue to evolve, grow, and flourish. Related Healthy Library Articles Suggested Use Warnings Do not use if you are pregnant, may become pregnant, or breastfeeding. Consult your physician before use if you are diabetic, have any blood coagulation or platelet disorder, or are taking any prescription drugs. By Cathy (Thetford Hill , VT ) Disclaimer: The views and opinions expressed by contributors of the product reviews are their own and not necessarily those of LuckyVitamin.com. LuckyVitamin.com does not endorse or imply any medical claims from these reviews. These reviews should not be taken as recommendations but rather customer opinions of the products that they may or may not have used. Reviews are not intended as a substitute for appropriate medical care or advice and are not intended to diagnose, treat, cure, or prevent any disease. Read the full product reviews disclaimer here. Discussions Manufacturer Info About Planetary Herbals Planetary Herbals have been developed by expert herbalists, focusing predominantly on the thousands of years of experience of Ayurvedic and traditional Chinese herbalism, the hundreds of years of experience of Western herbal practitioners, and the more than 30 years of clinical experience of professional herbalists such as Michael Tierra, Lesley Tierra, Jill Stansbury, and Alan Tillotson. Planetary Herbals offers the best of classic herbal traditions, integrating herbal formulas used continuously for literally hundreds of thousands of years, with the latest finding of clinical pharmacological research. Disclaimer *The products and the claims made about specific products on or through this site have not been evaluated by LuckyVitamin.com or the United States Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a health care professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. Description: Planetary Herbals Full Spectrum Ashwagandha (Winter Cherry) 570 mg. 120 Tablets Planetary Herbals Full Spectrum Ashwagandha (Winter Cherry) is one of the world's most powerful adaptogens, used traditionally in Ayurvedic herbalism to help the body adapt to physiological and psychological ... AUTOSHIP Save time with AutoShip Convenient: Schedule deliveries to your door Control: Easily manage your AutoShip deliveries Peace of mind: Never run out of your health & wellness products again Simplify your life and never run out of your vitamins and supplements with our automatic order replenishment program. Our program is the easiest way to reorder your products. As you shop, under the title 'Save Time with AUTOSHIP', to the right of the product, select the circle and then click the drop-down to select your shipping frequency. Then, add that item to your cart. Whenever your order ships, we bill your credit card. You can cancel or change your AutoShip frequency at anytime by contacting us. *Note: prices are subject to change and any such changes, positive or negative, will be automatically applied to items ordered through the program. Shipping costs will be added based on our current shipping terms. As if good health wasn't rewarding enough... When you sign up for a MyLucky account, you will automatically begin accruing LuckyReward Points for every qualifying item you buy on eligible purchases made online at LuckyVitamin.com or through our toll free number 1-888-635-0474. You will be able to track your LuckyReward Points online through your MyLucky account. Once you have earned 500 LuckyReward Points, you are eligible for a LuckyReward's Gift Certificate code that will be automatically delivered to you via email. LuckyReward Gift Certificates expire 60 days from receipt and can be used towards future LuckyVitamin.com purchases. They may also be combined with other offers. MAP - Minimum Advertised Price Sometimes, manufacturers require that products be advertised at their suggested price. In order to provide the best support from our manufacturer's and distributions, while continuing to offer a large product selection, we have agreed to abide by their "MAP" or minimum-advertised-price policy. When we choose to sell these items to you for less, we display the sale price only in our cart. You can see your special low sale cost for an item by clicking the product "Add to Cart" button or "See Price In Cart" link. Please be assured that simply adding an item to your cart does not obligate you to buy it. You can always change your mind and delete the item from your cart if you decide not to purchase it. Thank you You will receive an automated email alert when this item is back in stock at LuckyVitamin.com. Receive e-Mail Notification When Item is Back In Stock Planetary Herbals - Kudzu Full Spectrum 750 mg. - 120 Tablets The above item is currently unavailable from the manufacturer and is therefore out of stock. Please fill in the form below to receive a one time automated email alert which will confirm when this item is back in stock at LuckyVitamin.com. *NAME First name is required *EMAIL Email is required *Note: By submitting this information you will receive a one time notification alert to confirm when this item will be back in stock. You will not receive any other solicitation or notification from us regarding any promotional or other marketing information. We never rent, sell or share your email address. View our privacy policy. Shipping and handling charges are a flat rate of $5.95* for all orders using Standard Shipping and FREE for orders over $49* within the continental 48 U.S. only, excluding Hawaii, Alaska, Virgin Islands & Puerto Rico. LuckyVitamin.com offers a Same Day Shipping guarantee on most in-stock items ordered Monday - Friday by 1pm EST (excluding national holidays). Item eligibility can change depending on the day of the week, time of day, and product availability, so please check each item’s availability at the time of order. Only orders placed directly though LuckyVitamin.com qualify for Same Day Shipping. LuckyVitamin.com processes orders 7 days a week. We will ship all of our orders using either FedEx, USPS or DHL. Standard delivery time is 2-8 business days depending on delivery location. *Note: Some (very few) heavier/larger items include an additional handling fee and are indicated by the Blue Truck icon along with specific handling charges stated on the item's info page and at checkout.

2024-02-26T01:27:04.277712

https://example.com/article/4580