Datasets:

knowledgator

/

bio-NER-relations

like 3

Follow

Knowledgator Engineering 85

[ { "id": "1.0alpha7.train.172.sent", "type": "sentence", "text": [ "In fact, channelologists have had this idea for some time, but a rather general experimental finding has been that standard calmodulin inhibitors that block the calcium-dependent binding of calmodulin to its target proteins do not interfere with calcium regulation of ion channels." ], "offsets": [ [ 0, 281 ] ] } ]

[ { "id": "1.0alpha7.train.172.ent0_0", "type": "chemical", "text": [ "calcium" ], "offsets": [ [ 161, 168 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5460341" } ] }, { "id": "1.0alpha7.train.172.ent1_1", "type": "chemical", "text": [ "calcium" ], "offsets": [ [ 246, 253 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5460341" } ] }, { "id": "1.0alpha7.train.172.ent2_0", "type": "protein", "text": [ "calmodulin" ], "offsets": [ [ 124, 134 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "801" }, { "db_name": "hgnc", "db_id": "CALM1" }, { "db_name": "uniprot", "db_id": "P0DP23" } ] }, { "id": "1.0alpha7.train.172.ent3_1", "type": "protein", "text": [ "calmodulin" ], "offsets": [ [ 190, 200 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "801" }, { "db_name": "hgnc", "db_id": "CALM1" }, { "db_name": "uniprot", "db_id": "P0DP23" } ] } ]

[]

[ { "id": "1.0alpha7.train.172.coref0", "entity_ids": [ "1.0alpha7.train.172.ent0_0", "1.0alpha7.train.172.ent1_1" ] }, { "id": "1.0alpha7.train.172.coref1", "entity_ids": [ "1.0alpha7.train.172.ent2_0", "1.0alpha7.train.172.ent3_1" ] } ]

[]

[ { "id": "1.0alpha7.train.173.sent", "type": "sentence", "text": [ "The amount of S223F coat protein bound to GroEL increased when the GroEL concentration was raised regardless of temperature, suggesting that even at low temperatures the improper folding of S223F coat protein exceeded the capacity of GroEL to accommodate substrates." ], "offsets": [ [ 0, 266 ] ] } ]

[ { "id": "1.0alpha7.train.173.ent0_0", "type": "protein", "text": [ "GroEL" ], "offsets": [ [ 42, 47 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3329" }, { "db_name": "hgnc", "db_id": "HSPD1" }, { "db_name": "uniprot", "db_id": "P10809" } ] }, { "id": "1.0alpha7.train.173.ent1_1", "type": "protein", "text": [ "GroEL" ], "offsets": [ [ 67, 72 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3329" }, { "db_name": "hgnc", "db_id": "HSPD1" }, { "db_name": "uniprot", "db_id": "P10809" } ] }, { "id": "1.0alpha7.train.173.ent2_2", "type": "protein", "text": [ "GroEL" ], "offsets": [ [ 234, 239 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3329" }, { "db_name": "hgnc", "db_id": "HSPD1" }, { "db_name": "uniprot", "db_id": "P10809" } ] }, { "id": "1.0alpha7.train.173.ent3_0", "type": "protein", "text": [ "S223F coat protein" ], "offsets": [ [ 14, 32 ] ], "normalized": [] }, { "id": "1.0alpha7.train.173.ent4_1", "type": "protein", "text": [ "S223F coat protein" ], "offsets": [ [ 190, 208 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.173.coref0", "entity_ids": [ "1.0alpha7.train.173.ent0_0", "1.0alpha7.train.173.ent1_1", "1.0alpha7.train.173.ent2_2" ] }, { "id": "1.0alpha7.train.173.coref1", "entity_ids": [ "1.0alpha7.train.173.ent3_0", "1.0alpha7.train.173.ent4_1" ] } ]

[ { "id": "1.0alpha7.train.173.rel0s1.0alpha7.train.173.ent0_0.o1.0alpha7.train.173.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.173.ent0_0", "arg2_id": "1.0alpha7.train.173.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.173.rel0s1.0alpha7.train.173.ent0_0.o1.0alpha7.train.173.ent4_1", "type": "bind", "arg1_id": "1.0alpha7.train.173.ent0_0", "arg2_id": "1.0alpha7.train.173.ent4_1", "normalized": [] }, { "id": "1.0alpha7.train.173.rel0s1.0alpha7.train.173.ent1_1.o1.0alpha7.train.173.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.173.ent1_1", "arg2_id": "1.0alpha7.train.173.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.173.rel0s1.0alpha7.train.173.ent1_1.o1.0alpha7.train.173.ent4_1", "type": "bind", "arg1_id": "1.0alpha7.train.173.ent1_1", "arg2_id": "1.0alpha7.train.173.ent4_1", "normalized": [] }, { "id": "1.0alpha7.train.173.rel0s1.0alpha7.train.173.ent2_2.o1.0alpha7.train.173.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.173.ent2_2", "arg2_id": "1.0alpha7.train.173.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.173.rel0s1.0alpha7.train.173.ent2_2.o1.0alpha7.train.173.ent4_1", "type": "bind", "arg1_id": "1.0alpha7.train.173.ent2_2", "arg2_id": "1.0alpha7.train.173.ent4_1", "normalized": [] } ]

[ { "id": "1.0alpha7.train.174.sent", "type": "sentence", "text": [ "The demonstration that Axin binds GSK-3 and beta-catenin and promotes GSK-3 phosphorylation of beta-catenin suggested that Axin might be the target of the dnXgsk-3." ], "offsets": [ [ 0, 164 ] ] } ]

[ { "id": "1.0alpha7.train.174.ent0_0", "type": "protein", "text": [ "beta-catenin" ], "offsets": [ [ 44, 56 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1499" }, { "db_name": "hgnc", "db_id": "CTNNB1" }, { "db_name": "uniprot", "db_id": "P35222" } ] }, { "id": "1.0alpha7.train.174.ent1_1", "type": "protein", "text": [ "beta-catenin" ], "offsets": [ [ 95, 107 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1499" }, { "db_name": "hgnc", "db_id": "CTNNB1" }, { "db_name": "uniprot", "db_id": "P35222" } ] }, { "id": "1.0alpha7.train.174.ent2_0", "type": "protein", "text": [ "Axin" ], "offsets": [ [ 23, 27 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8312" }, { "db_name": "hgnc", "db_id": "AXIN1" }, { "db_name": "uniprot", "db_id": "O15169" } ] }, { "id": "1.0alpha7.train.174.ent3_1", "type": "protein", "text": [ "Axin" ], "offsets": [ [ 123, 127 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8312" }, { "db_name": "hgnc", "db_id": "AXIN1" }, { "db_name": "uniprot", "db_id": "O15169" } ] }, { "id": "1.0alpha7.train.174.ent4_0", "type": "protein", "text": [ "dnXgsk-3" ], "offsets": [ [ 155, 163 ] ], "normalized": [] }, { "id": "1.0alpha7.train.174.ent5_0", "type": "protein", "text": [ "GSK-3" ], "offsets": [ [ 34, 39 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2931" }, { "db_name": "hgnc", "db_id": "GSK3A" }, { "db_name": "uniprot", "db_id": "P49840" } ] }, { "id": "1.0alpha7.train.174.ent6_1", "type": "protein", "text": [ "GSK-3" ], "offsets": [ [ 70, 75 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2931" }, { "db_name": "hgnc", "db_id": "GSK3A" }, { "db_name": "uniprot", "db_id": "P49840" } ] } ]

[]

[ { "id": "1.0alpha7.train.174.coref0", "entity_ids": [ "1.0alpha7.train.174.ent0_0", "1.0alpha7.train.174.ent1_1" ] }, { "id": "1.0alpha7.train.174.coref1", "entity_ids": [ "1.0alpha7.train.174.ent2_0", "1.0alpha7.train.174.ent3_1" ] }, { "id": "1.0alpha7.train.174.coref2", "entity_ids": [ "1.0alpha7.train.174.ent4_0" ] }, { "id": "1.0alpha7.train.174.coref3", "entity_ids": [ "1.0alpha7.train.174.ent5_0", "1.0alpha7.train.174.ent6_1" ] } ]

[ { "id": "1.0alpha7.train.174.rel0s1.0alpha7.train.174.ent2_0.o1.0alpha7.train.174.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.174.ent2_0", "arg2_id": "1.0alpha7.train.174.ent5_0", "normalized": [] }, { "id": "1.0alpha7.train.174.rel0s1.0alpha7.train.174.ent2_0.o1.0alpha7.train.174.ent6_1", "type": "bind", "arg1_id": "1.0alpha7.train.174.ent2_0", "arg2_id": "1.0alpha7.train.174.ent6_1", "normalized": [] }, { "id": "1.0alpha7.train.174.rel0s1.0alpha7.train.174.ent3_1.o1.0alpha7.train.174.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.174.ent3_1", "arg2_id": "1.0alpha7.train.174.ent5_0", "normalized": [] }, { "id": "1.0alpha7.train.174.rel0s1.0alpha7.train.174.ent3_1.o1.0alpha7.train.174.ent6_1", "type": "bind", "arg1_id": "1.0alpha7.train.174.ent3_1", "arg2_id": "1.0alpha7.train.174.ent6_1", "normalized": [] }, { "id": "1.0alpha7.train.174.rel1s1.0alpha7.train.174.ent0_0.o1.0alpha7.train.174.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.174.ent0_0", "arg2_id": "1.0alpha7.train.174.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.174.rel1s1.0alpha7.train.174.ent0_0.o1.0alpha7.train.174.ent3_1", "type": "bind", "arg1_id": "1.0alpha7.train.174.ent0_0", "arg2_id": "1.0alpha7.train.174.ent3_1", "normalized": [] }, { "id": "1.0alpha7.train.174.rel1s1.0alpha7.train.174.ent1_1.o1.0alpha7.train.174.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.174.ent1_1", "arg2_id": "1.0alpha7.train.174.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.174.rel1s1.0alpha7.train.174.ent1_1.o1.0alpha7.train.174.ent3_1", "type": "bind", "arg1_id": "1.0alpha7.train.174.ent1_1", "arg2_id": "1.0alpha7.train.174.ent3_1", "normalized": [] } ]

[ { "id": "1.0alpha7.train.175.sent", "type": "sentence", "text": [ "In complex with the drug FK506, FKBP12 binds calcineurin, inhibiting calcineurin's phosphatase activity and thus its ability to activate the transcription factor NF-AT in the T-cell receptor signal transduction pathway ( 170)." ], "offsets": [ [ 0, 226 ] ] } ]

[ { "id": "1.0alpha7.train.175.ent0_0", "type": "protein-family", "text": [ "T-cell receptor" ], "offsets": [ [ 175, 190 ] ], "normalized": [] }, { "id": "1.0alpha7.train.175.ent1_0", "type": "protein", "text": [ "calcineurin" ], "offsets": [ [ 45, 56 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5530" }, { "db_name": "hgnc", "db_id": "PPP3CA" }, { "db_name": "uniprot", "db_id": "Q08209" } ] }, { "id": "1.0alpha7.train.175.ent2_1", "type": "protein", "text": [ "calcineurin" ], "offsets": [ [ 69, 80 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5530" }, { "db_name": "hgnc", "db_id": "PPP3CA" }, { "db_name": "uniprot", "db_id": "Q08209" } ] }, { "id": "1.0alpha7.train.175.ent3_0", "type": "chemical", "text": [ "FK506" ], "offsets": [ [ 25, 30 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "445643" } ] }, { "id": "1.0alpha7.train.175.ent4_0", "type": "cell", "text": [ "T-cell" ], "offsets": [ [ 175, 181 ] ], "normalized": [] }, { "id": "1.0alpha7.train.175.ent5_0", "type": "protein", "text": [ "FKBP12" ], "offsets": [ [ 32, 38 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2280" }, { "db_name": "hgnc", "db_id": "FKBP1A" }, { "db_name": "uniprot", "db_id": "P62942" } ] }, { "id": "1.0alpha7.train.175.ent6_0", "type": "protein-family", "text": [ "NF-AT" ], "offsets": [ [ 162, 167 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR008366" } ] } ]

[]

[ { "id": "1.0alpha7.train.175.coref0", "entity_ids": [ "1.0alpha7.train.175.ent0_0" ] }, { "id": "1.0alpha7.train.175.coref1", "entity_ids": [ "1.0alpha7.train.175.ent1_0", "1.0alpha7.train.175.ent2_1" ] }, { "id": "1.0alpha7.train.175.coref2", "entity_ids": [ "1.0alpha7.train.175.ent3_0" ] }, { "id": "1.0alpha7.train.175.coref3", "entity_ids": [ "1.0alpha7.train.175.ent4_0" ] }, { "id": "1.0alpha7.train.175.coref4", "entity_ids": [ "1.0alpha7.train.175.ent5_0" ] }, { "id": "1.0alpha7.train.175.coref5", "entity_ids": [ "1.0alpha7.train.175.ent6_0" ] } ]

[ { "id": "1.0alpha7.train.175.rel0s1.0alpha7.train.175.ent3_0.o1.0alpha7.train.175.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.175.ent3_0", "arg2_id": "1.0alpha7.train.175.ent5_0", "normalized": [] }, { "id": "1.0alpha7.train.175.rel1s1.0alpha7.train.175.ent1_0.o1.0alpha7.train.175.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.175.ent1_0", "arg2_id": "1.0alpha7.train.175.ent5_0", "normalized": [] }, { "id": "1.0alpha7.train.175.rel1s1.0alpha7.train.175.ent2_1.o1.0alpha7.train.175.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.175.ent2_1", "arg2_id": "1.0alpha7.train.175.ent5_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.176.sent", "type": "sentence", "text": [ "CREB phosphorylation enhances CREB binding to CREB-binding protein, thus activating gene transcription via the CRE ( 29)." ], "offsets": [ [ 0, 121 ] ] } ]

[ { "id": "1.0alpha7.train.176.ent0_0", "type": "protein", "text": [ "CREB" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1385" }, { "db_name": "hgnc", "db_id": "CREB1" }, { "db_name": "uniprot", "db_id": "P16220" } ] }, { "id": "1.0alpha7.train.176.ent1_1", "type": "protein", "text": [ "CREB" ], "offsets": [ [ 30, 34 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1385" }, { "db_name": "hgnc", "db_id": "CREB1" }, { "db_name": "uniprot", "db_id": "P16220" } ] }, { "id": "1.0alpha7.train.176.ent2_2", "type": "protein", "text": [ "CREB" ], "offsets": [ [ 46, 50 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1385" }, { "db_name": "hgnc", "db_id": "CREB1" }, { "db_name": "uniprot", "db_id": "P16220" } ] }, { "id": "1.0alpha7.train.176.ent3_0", "type": "protein", "text": [ "CREB-binding protein" ], "offsets": [ [ 46, 66 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1387" }, { "db_name": "hgnc", "db_id": "CREBBP" }, { "db_name": "uniprot", "db_id": "Q92793" } ] }, { "id": "1.0alpha7.train.176.ent4_0", "type": "DNA", "text": [ "CRE" ], "offsets": [ [ 111, 114 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.176.coref0", "entity_ids": [ "1.0alpha7.train.176.ent0_0", "1.0alpha7.train.176.ent1_1", "1.0alpha7.train.176.ent2_2" ] }, { "id": "1.0alpha7.train.176.coref1", "entity_ids": [ "1.0alpha7.train.176.ent3_0" ] }, { "id": "1.0alpha7.train.176.coref2", "entity_ids": [ "1.0alpha7.train.176.ent4_0" ] } ]

[ { "id": "1.0alpha7.train.176.rel0s1.0alpha7.train.176.ent0_0.o1.0alpha7.train.176.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.176.ent0_0", "arg2_id": "1.0alpha7.train.176.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.176.rel0s1.0alpha7.train.176.ent1_1.o1.0alpha7.train.176.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.176.ent1_1", "arg2_id": "1.0alpha7.train.176.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.176.rel0s1.0alpha7.train.176.ent2_2.o1.0alpha7.train.176.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.176.ent2_2", "arg2_id": "1.0alpha7.train.176.ent3_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.177.sent", "type": "sentence", "text": [ "Still other mechanisms are likely to be highly receptor-specific: the binding of NHERF to the β2-adrenergic receptor and the binding of Homer to metabotropic glutamate receptors, for example, depend on the presence of precise motifs that are likely to be found in few other heptahelical receptors, although other receptors are likely to contain slightly modified motifs that mediate binding to other specific PDZ or polyproline-binding domains." ], "offsets": [ [ 0, 444 ] ] } ]

[ { "id": "1.0alpha7.train.177.ent0_0", "type": "protein-family", "text": [ "Homer" ], "offsets": [ [ 136, 141 ] ], "normalized": [] }, { "id": "1.0alpha7.train.177.ent1_0", "type": "protein-domain", "text": [ "PDZ" ], "offsets": [ [ 409, 412 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR001478" } ] }, { "id": "1.0alpha7.train.177.ent2_0", "type": "protein-family", "text": [ "metabotropic glutamate receptors" ], "offsets": [ [ 145, 177 ] ], "normalized": [] }, { "id": "1.0alpha7.train.177.ent3_0", "type": "protein-family", "text": [ "β2-adrenergic receptor" ], "offsets": [ [ 94, 116 ] ], "normalized": [] }, { "id": "1.0alpha7.train.177.ent4_0", "type": "protein-family", "text": [ "NHERF" ], "offsets": [ [ 81, 86 ] ], "normalized": [] }, { "id": "1.0alpha7.train.177.ent5_0", "type": "protein-domain", "text": [ "polyproline-binding domains" ], "offsets": [ [ 416, 443 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.177.coref0", "entity_ids": [ "1.0alpha7.train.177.ent0_0" ] }, { "id": "1.0alpha7.train.177.coref1", "entity_ids": [ "1.0alpha7.train.177.ent1_0" ] }, { "id": "1.0alpha7.train.177.coref2", "entity_ids": [ "1.0alpha7.train.177.ent2_0" ] }, { "id": "1.0alpha7.train.177.coref3", "entity_ids": [ "1.0alpha7.train.177.ent3_0" ] }, { "id": "1.0alpha7.train.177.coref4", "entity_ids": [ "1.0alpha7.train.177.ent4_0" ] }, { "id": "1.0alpha7.train.177.coref5", "entity_ids": [ "1.0alpha7.train.177.ent5_0" ] } ]

[ { "id": "1.0alpha7.train.177.rel0s1.0alpha7.train.177.ent3_0.o1.0alpha7.train.177.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.177.ent3_0", "arg2_id": "1.0alpha7.train.177.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.177.rel1s1.0alpha7.train.177.ent0_0.o1.0alpha7.train.177.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.177.ent0_0", "arg2_id": "1.0alpha7.train.177.ent2_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.178.sent", "type": "sentence", "text": [ "( A) U1 snRNP binds to the dsx pre-mRNA independently of the ESE, whereas the ESE and U1 snRNP are required for the assembly of U2, U4/U6, and U5 snRNPs on the dsx pre-mRNA." ], "offsets": [ [ 0, 173 ] ] } ]

[ { "id": "1.0alpha7.train.178.ent0_0", "type": "RNA", "text": [ "dsx pre-mRNA" ], "offsets": [ [ 27, 39 ] ], "normalized": [] }, { "id": "1.0alpha7.train.178.ent1_1", "type": "RNA", "text": [ "dsx pre-mRNA" ], "offsets": [ [ 160, 172 ] ], "normalized": [] }, { "id": "1.0alpha7.train.178.ent2_0", "type": "protein-complex", "text": [ "snRNPs" ], "offsets": [ [ 146, 152 ] ], "normalized": [] }, { "id": "1.0alpha7.train.178.ent3_0", "type": "RNA", "text": [ "U1 snRNP" ], "offsets": [ [ 5, 13 ] ], "normalized": [] }, { "id": "1.0alpha7.train.178.ent4_1", "type": "RNA", "text": [ "U1 snRNP" ], "offsets": [ [ 86, 94 ] ], "normalized": [] }, { "id": "1.0alpha7.train.178.ent5_0", "type": "RNA", "text": [ "U5" ], "offsets": [ [ 143, 145 ] ], "normalized": [] }, { "id": "1.0alpha7.train.178.ent6_0", "type": "RNA", "text": [ "U4/U6" ], "offsets": [ [ 132, 137 ] ], "normalized": [] }, { "id": "1.0alpha7.train.178.ent7_0", "type": "RNA", "text": [ "U2" ], "offsets": [ [ 128, 130 ] ], "normalized": [] }, { "id": "1.0alpha7.train.178.ent8_0", "type": "DNA", "text": [ "ESE" ], "offsets": [ [ 61, 64 ] ], "normalized": [] }, { "id": "1.0alpha7.train.178.ent9_1", "type": "DNA", "text": [ "ESE" ], "offsets": [ [ 78, 81 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.178.coref0", "entity_ids": [ "1.0alpha7.train.178.ent0_0", "1.0alpha7.train.178.ent1_1" ] }, { "id": "1.0alpha7.train.178.coref1", "entity_ids": [ "1.0alpha7.train.178.ent2_0" ] }, { "id": "1.0alpha7.train.178.coref2", "entity_ids": [ "1.0alpha7.train.178.ent3_0", "1.0alpha7.train.178.ent4_1" ] }, { "id": "1.0alpha7.train.178.coref3", "entity_ids": [ "1.0alpha7.train.178.ent5_0" ] }, { "id": "1.0alpha7.train.178.coref4", "entity_ids": [ "1.0alpha7.train.178.ent6_0" ] }, { "id": "1.0alpha7.train.178.coref5", "entity_ids": [ "1.0alpha7.train.178.ent7_0" ] }, { "id": "1.0alpha7.train.178.coref6", "entity_ids": [ "1.0alpha7.train.178.ent8_0", "1.0alpha7.train.178.ent9_1" ] } ]

[ { "id": "1.0alpha7.train.178.rel0s1.0alpha7.train.178.ent0_0.o1.0alpha7.train.178.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.178.ent0_0", "arg2_id": "1.0alpha7.train.178.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.178.rel0s1.0alpha7.train.178.ent0_0.o1.0alpha7.train.178.ent4_1", "type": "bind", "arg1_id": "1.0alpha7.train.178.ent0_0", "arg2_id": "1.0alpha7.train.178.ent4_1", "normalized": [] }, { "id": "1.0alpha7.train.178.rel0s1.0alpha7.train.178.ent1_1.o1.0alpha7.train.178.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.178.ent1_1", "arg2_id": "1.0alpha7.train.178.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.178.rel0s1.0alpha7.train.178.ent1_1.o1.0alpha7.train.178.ent4_1", "type": "bind", "arg1_id": "1.0alpha7.train.178.ent1_1", "arg2_id": "1.0alpha7.train.178.ent4_1", "normalized": [] }, { "id": "1.0alpha7.train.178.rel1s1.0alpha7.train.178.ent0_0.o1.0alpha7.train.178.ent7_0", "type": "bind", "arg1_id": "1.0alpha7.train.178.ent0_0", "arg2_id": "1.0alpha7.train.178.ent7_0", "normalized": [] }, { "id": "1.0alpha7.train.178.rel1s1.0alpha7.train.178.ent1_1.o1.0alpha7.train.178.ent7_0", "type": "bind", "arg1_id": "1.0alpha7.train.178.ent1_1", "arg2_id": "1.0alpha7.train.178.ent7_0", "normalized": [] }, { "id": "1.0alpha7.train.178.rel2s1.0alpha7.train.178.ent0_0.o1.0alpha7.train.178.ent6_0", "type": "bind", "arg1_id": "1.0alpha7.train.178.ent0_0", "arg2_id": "1.0alpha7.train.178.ent6_0", "normalized": [] }, { "id": "1.0alpha7.train.178.rel2s1.0alpha7.train.178.ent1_1.o1.0alpha7.train.178.ent6_0", "type": "bind", "arg1_id": "1.0alpha7.train.178.ent1_1", "arg2_id": "1.0alpha7.train.178.ent6_0", "normalized": [] }, { "id": "1.0alpha7.train.178.rel3s1.0alpha7.train.178.ent0_0.o1.0alpha7.train.178.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.178.ent0_0", "arg2_id": "1.0alpha7.train.178.ent5_0", "normalized": [] }, { "id": "1.0alpha7.train.178.rel3s1.0alpha7.train.178.ent1_1.o1.0alpha7.train.178.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.178.ent1_1", "arg2_id": "1.0alpha7.train.178.ent5_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.179.sent", "type": "sentence", "text": [ "First, p21 binds PCNA ( 15) through a region found by Chuang et al. to be similar to, and to compete with, the site in DNA-MCMT that mediates PCNA binding." ], "offsets": [ [ 0, 155 ] ] } ]

[ { "id": "1.0alpha7.train.179.ent0_0", "type": "protein", "text": [ "PCNA" ], "offsets": [ [ 17, 21 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5111" }, { "db_name": "hgnc", "db_id": "PCNA" }, { "db_name": "uniprot", "db_id": "P12004" } ] }, { "id": "1.0alpha7.train.179.ent1_1", "type": "protein", "text": [ "PCNA" ], "offsets": [ [ 142, 146 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5111" }, { "db_name": "hgnc", "db_id": "PCNA" }, { "db_name": "uniprot", "db_id": "P12004" } ] }, { "id": "1.0alpha7.train.179.ent2_0", "type": "protein", "text": [ "p21" ], "offsets": [ [ 7, 10 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1026" }, { "db_name": "hgnc", "db_id": "CDKN1A" }, { "db_name": "uniprot", "db_id": "P38936" } ] }, { "id": "1.0alpha7.train.179.ent3_0", "type": "protein", "text": [ "DNA-MCMT" ], "offsets": [ [ 119, 127 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1786" }, { "db_name": "hgnc", "db_id": "DNMT1" }, { "db_name": "uniprot", "db_id": "P26358" } ] } ]

[]

[ { "id": "1.0alpha7.train.179.coref0", "entity_ids": [ "1.0alpha7.train.179.ent0_0", "1.0alpha7.train.179.ent1_1" ] }, { "id": "1.0alpha7.train.179.coref1", "entity_ids": [ "1.0alpha7.train.179.ent2_0" ] }, { "id": "1.0alpha7.train.179.coref2", "entity_ids": [ "1.0alpha7.train.179.ent3_0" ] } ]

[ { "id": "1.0alpha7.train.179.rel0s1.0alpha7.train.179.ent0_0.o1.0alpha7.train.179.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.179.ent0_0", "arg2_id": "1.0alpha7.train.179.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.179.rel0s1.0alpha7.train.179.ent1_1.o1.0alpha7.train.179.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.179.ent1_1", "arg2_id": "1.0alpha7.train.179.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.179.rel1s1.0alpha7.train.179.ent0_0.o1.0alpha7.train.179.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.179.ent0_0", "arg2_id": "1.0alpha7.train.179.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.179.rel1s1.0alpha7.train.179.ent1_1.o1.0alpha7.train.179.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.179.ent1_1", "arg2_id": "1.0alpha7.train.179.ent3_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.180.sent", "type": "sentence", "text": [ "As shown in Figure ​7A (panels labeled ‘GAL4’), GAL4 WT, DB·CR and DB·AD bound more readily than the DNA-binding domain alone to an artificial promoter, which bears four GAL4 sites fused to an unrelated HIS4 basal promoter." ], "offsets": [ [ 0, 223 ] ] } ]

[ { "id": "1.0alpha7.train.180.ent0_0", "type": "protein-region", "text": [ "DB·AD" ], "offsets": [ [ 67, 72 ] ], "normalized": [] }, { "id": "1.0alpha7.train.180.ent1_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 101, 104 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.180.ent2_0", "type": "DNA", "text": [ "GAL4 sites" ], "offsets": [ [ 170, 180 ] ], "normalized": [] }, { "id": "1.0alpha7.train.180.ent3_0", "type": "protein-domain", "text": [ "DNA-binding domain" ], "offsets": [ [ 101, 119 ] ], "normalized": [] }, { "id": "1.0alpha7.train.180.ent4_0", "type": "protein-region", "text": [ "GAL4 WT" ], "offsets": [ [ 48, 55 ] ], "normalized": [] }, { "id": "1.0alpha7.train.180.ent5_0", "type": "protein-region", "text": [ "DB·CR" ], "offsets": [ [ 57, 62 ] ], "normalized": [] }, { "id": "1.0alpha7.train.180.ent6_0", "type": "DNA", "text": [ "HIS4 basal promoter" ], "offsets": [ [ 203, 222 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.180.coref0", "entity_ids": [ "1.0alpha7.train.180.ent0_0" ] }, { "id": "1.0alpha7.train.180.coref1", "entity_ids": [ "1.0alpha7.train.180.ent1_0" ] }, { "id": "1.0alpha7.train.180.coref2", "entity_ids": [ "1.0alpha7.train.180.ent2_0" ] }, { "id": "1.0alpha7.train.180.coref3", "entity_ids": [ "1.0alpha7.train.180.ent3_0" ] }, { "id": "1.0alpha7.train.180.coref4", "entity_ids": [ "1.0alpha7.train.180.ent4_0" ] }, { "id": "1.0alpha7.train.180.coref5", "entity_ids": [ "1.0alpha7.train.180.ent5_0" ] }, { "id": "1.0alpha7.train.180.coref6", "entity_ids": [ "1.0alpha7.train.180.ent6_0" ] } ]

[ { "id": "1.0alpha7.train.180.rel0s1.0alpha7.train.180.ent1_0.o1.0alpha7.train.180.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.180.ent1_0", "arg2_id": "1.0alpha7.train.180.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.180.rel1s1.0alpha7.train.180.ent0_0.o1.0alpha7.train.180.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.180.ent0_0", "arg2_id": "1.0alpha7.train.180.ent1_0", "normalized": [] }, { "id": "1.0alpha7.train.180.rel2s1.0alpha7.train.180.ent1_0.o1.0alpha7.train.180.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.180.ent1_0", "arg2_id": "1.0alpha7.train.180.ent5_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.181.sent", "type": "sentence", "text": [ "The cytoplasmic domain of the cadherin can bind directly to p120ctn as well as beta-catenin, and either protein could play a role in growth suppression." ], "offsets": [ [ 0, 152 ] ] } ]

[ { "id": "1.0alpha7.train.181.ent0_0", "type": "protein-family", "text": [ "cadherin" ], "offsets": [ [ 30, 38 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR039808" } ] }, { "id": "1.0alpha7.train.181.ent1_0", "type": "protein", "text": [ "beta-catenin" ], "offsets": [ [ 79, 91 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1499" }, { "db_name": "hgnc", "db_id": "CTNNB1" }, { "db_name": "uniprot", "db_id": "P35222" } ] }, { "id": "1.0alpha7.train.181.ent2_0", "type": "protein-domain", "text": [ "cytoplasmic domain" ], "offsets": [ [ 4, 22 ] ], "normalized": [] }, { "id": "1.0alpha7.train.181.ent3_0", "type": "protein", "text": [ "p120ctn" ], "offsets": [ [ 60, 67 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1500" }, { "db_name": "hgnc", "db_id": "CTNND1" }, { "db_name": "uniprot", "db_id": "O60716" } ] } ]

[]

[ { "id": "1.0alpha7.train.181.coref0", "entity_ids": [ "1.0alpha7.train.181.ent0_0" ] }, { "id": "1.0alpha7.train.181.coref1", "entity_ids": [ "1.0alpha7.train.181.ent1_0" ] }, { "id": "1.0alpha7.train.181.coref2", "entity_ids": [ "1.0alpha7.train.181.ent2_0" ] }, { "id": "1.0alpha7.train.181.coref3", "entity_ids": [ "1.0alpha7.train.181.ent3_0" ] } ]

[ { "id": "1.0alpha7.train.181.rel0s1.0alpha7.train.181.ent0_0.o1.0alpha7.train.181.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.181.ent0_0", "arg2_id": "1.0alpha7.train.181.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.181.rel1s1.0alpha7.train.181.ent0_0.o1.0alpha7.train.181.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.181.ent0_0", "arg2_id": "1.0alpha7.train.181.ent1_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.182.sent", "type": "sentence", "text": [ "As a consequence, Armadillo is no longer bound by Axin, resulting in nuclear signaling by Armadillo." ], "offsets": [ [ 0, 100 ] ] } ]

[ { "id": "1.0alpha7.train.182.ent0_0", "type": "protein", "text": [ "Axin" ], "offsets": [ [ 50, 54 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8312" }, { "db_name": "hgnc", "db_id": "AXIN1" }, { "db_name": "uniprot", "db_id": "O15169" } ] }, { "id": "1.0alpha7.train.182.ent1_0", "type": "protein-motif", "text": [ "Armadillo" ], "offsets": [ [ 18, 27 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR000225" } ] }, { "id": "1.0alpha7.train.182.ent2_1", "type": "protein-motif", "text": [ "Armadillo" ], "offsets": [ [ 90, 99 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR000225" } ] } ]

[]

[ { "id": "1.0alpha7.train.182.coref0", "entity_ids": [ "1.0alpha7.train.182.ent0_0" ] }, { "id": "1.0alpha7.train.182.coref1", "entity_ids": [ "1.0alpha7.train.182.ent1_0", "1.0alpha7.train.182.ent2_1" ] } ]

[ { "id": "1.0alpha7.train.182.rel0s1.0alpha7.train.182.ent0_0.o1.0alpha7.train.182.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.182.ent0_0", "arg2_id": "1.0alpha7.train.182.ent1_0", "normalized": [] }, { "id": "1.0alpha7.train.182.rel0s1.0alpha7.train.182.ent0_0.o1.0alpha7.train.182.ent2_1", "type": "bind", "arg1_id": "1.0alpha7.train.182.ent0_0", "arg2_id": "1.0alpha7.train.182.ent2_1", "normalized": [] } ]

[ { "id": "1.0alpha7.train.183.sent", "type": "sentence", "text": [ "Assay for CD22Rg Binding to HEC After washing with Medium 199, HEC were incubated with 2.5 mug/ ml CD22 mRg in Medium 199, 1% BSA at 4 degrees C for 2 h, in the absence or presence of alpha2-6-sLac or alpha2-3-sLac, plasma, IgM, haptoglobin, or IgG." ], "offsets": [ [ 0, 249 ] ] } ]

[ { "id": "1.0alpha7.train.183.ent0_0", "type": "reagent", "text": [ "alpha2-6-sLac" ], "offsets": [ [ 184, 197 ] ], "normalized": [] }, { "id": "1.0alpha7.train.183.ent1_0", "type": "reagent", "text": [ "CD22 mRg" ], "offsets": [ [ 99, 107 ] ], "normalized": [] }, { "id": "1.0alpha7.train.183.ent2_0", "type": "protein", "text": [ "CD22" ], "offsets": [ [ 99, 103 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "933" }, { "db_name": "hgnc", "db_id": "CD22" } ] }, { "id": "1.0alpha7.train.183.ent3_0", "type": "reagent", "text": [ "haptoglobin" ], "offsets": [ [ 229, 240 ] ], "normalized": [] }, { "id": "1.0alpha7.train.183.ent4_0", "type": "reagent", "text": [ "IgG" ], "offsets": [ [ 245, 248 ] ], "normalized": [] }, { "id": "1.0alpha7.train.183.ent5_0", "type": "cell", "text": [ "HEC" ], "offsets": [ [ 28, 31 ] ], "normalized": [] }, { "id": "1.0alpha7.train.183.ent6_1", "type": "cell", "text": [ "HEC" ], "offsets": [ [ 63, 66 ] ], "normalized": [] }, { "id": "1.0alpha7.train.183.ent7_0", "type": "reagent", "text": [ "IgM" ], "offsets": [ [ 224, 227 ] ], "normalized": [] }, { "id": "1.0alpha7.train.183.ent8_0", "type": "reagent", "text": [ "BSA" ], "offsets": [ [ 126, 129 ] ], "normalized": [] }, { "id": "1.0alpha7.train.183.ent9_0", "type": "fusion-protein", "text": [ "CD22Rg" ], "offsets": [ [ 10, 16 ] ], "normalized": [] }, { "id": "1.0alpha7.train.183.ent10_0", "type": "reagent", "text": [ "alpha2-3-sLac" ], "offsets": [ [ 201, 214 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.183.coref0", "entity_ids": [ "1.0alpha7.train.183.ent0_0" ] }, { "id": "1.0alpha7.train.183.coref1", "entity_ids": [ "1.0alpha7.train.183.ent1_0" ] }, { "id": "1.0alpha7.train.183.coref2", "entity_ids": [ "1.0alpha7.train.183.ent2_0" ] }, { "id": "1.0alpha7.train.183.coref3", "entity_ids": [ "1.0alpha7.train.183.ent3_0" ] }, { "id": "1.0alpha7.train.183.coref4", "entity_ids": [ "1.0alpha7.train.183.ent4_0" ] }, { "id": "1.0alpha7.train.183.coref5", "entity_ids": [ "1.0alpha7.train.183.ent5_0", "1.0alpha7.train.183.ent6_1" ] }, { "id": "1.0alpha7.train.183.coref6", "entity_ids": [ "1.0alpha7.train.183.ent7_0" ] }, { "id": "1.0alpha7.train.183.coref7", "entity_ids": [ "1.0alpha7.train.183.ent8_0" ] }, { "id": "1.0alpha7.train.183.coref8", "entity_ids": [ "1.0alpha7.train.183.ent9_0" ] }, { "id": "1.0alpha7.train.183.coref9", "entity_ids": [ "1.0alpha7.train.183.ent10_0" ] } ]

[]

[ { "id": "1.0alpha7.train.184.sent", "type": "sentence", "text": [ "Moreover, it has been found that acetyl-CoA can enhance the transcription of naked DNA (greater than 5-fold) as well as the binding of TFIID to promoter DNA in the absence of histones ( 35)." ], "offsets": [ [ 0, 190 ] ] } ]

[ { "id": "1.0alpha7.train.184.ent0_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 83, 86 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.184.ent1_1", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 153, 156 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.184.ent2_0", "type": "protein", "text": [ "TFIID" ], "offsets": [ [ 135, 140 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6908" }, { "db_name": "hgnc", "db_id": "TBP" }, { "db_name": "uniprot", "db_id": "P20226" } ] }, { "id": "1.0alpha7.train.184.ent3_0", "type": "chemical", "text": [ "acetyl-CoA" ], "offsets": [ [ 33, 43 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "444493" } ] } ]

[]

[ { "id": "1.0alpha7.train.184.coref0", "entity_ids": [ "1.0alpha7.train.184.ent0_0", "1.0alpha7.train.184.ent1_1" ] }, { "id": "1.0alpha7.train.184.coref1", "entity_ids": [ "1.0alpha7.train.184.ent2_0" ] }, { "id": "1.0alpha7.train.184.coref2", "entity_ids": [ "1.0alpha7.train.184.ent3_0" ] } ]

[ { "id": "1.0alpha7.train.184.rel0s1.0alpha7.train.184.ent0_0.o1.0alpha7.train.184.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.184.ent0_0", "arg2_id": "1.0alpha7.train.184.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.184.rel0s1.0alpha7.train.184.ent1_1.o1.0alpha7.train.184.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.184.ent1_1", "arg2_id": "1.0alpha7.train.184.ent2_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.185.sent", "type": "sentence", "text": [ "Rapid regulation of Cdk5 activity could occur by increased binding of free p35 to monomeric Cdk5, particularly as the generally low cytoplasmic levels of p35 (30,54) are under strict regulation, with rapid p35 turnover (half-life 20–30 min) controlled by a ubiquitin-proteasome pathway (27)." ], "offsets": [ [ 0, 291 ] ] } ]

[ { "id": "1.0alpha7.train.185.ent0_0", "type": "protein-complex", "text": [ "proteasome" ], "offsets": [ [ 267, 277 ] ], "normalized": [] }, { "id": "1.0alpha7.train.185.ent1_0", "type": "protein-family", "text": [ "ubiquitin" ], "offsets": [ [ 257, 266 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR000626" } ] }, { "id": "1.0alpha7.train.185.ent2_0", "type": "process", "text": [ "ubiquitin-proteasome pathway" ], "offsets": [ [ 257, 285 ] ], "normalized": [ { "db_name": "kegg", "db_id": "ko04120" } ] }, { "id": "1.0alpha7.train.185.ent3_0", "type": "protein", "text": [ "Cdk5" ], "offsets": [ [ 20, 24 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1020" }, { "db_name": "hgnc", "db_id": "CDK5" }, { "db_name": "uniprot", "db_id": "Q00535" } ] }, { "id": "1.0alpha7.train.185.ent4_1", "type": "protein", "text": [ "Cdk5" ], "offsets": [ [ 92, 96 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1020" }, { "db_name": "hgnc", "db_id": "CDK5" }, { "db_name": "uniprot", "db_id": "Q00535" } ] }, { "id": "1.0alpha7.train.185.ent5_0", "type": "protein", "text": [ "p35" ], "offsets": [ [ 75, 78 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8851" }, { "db_name": "hgnc", "db_id": "CDK5R1" }, { "db_name": "uniprot", "db_id": "Q15078" } ] }, { "id": "1.0alpha7.train.185.ent6_1", "type": "protein", "text": [ "p35" ], "offsets": [ [ 154, 157 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8851" }, { "db_name": "hgnc", "db_id": "CDK5R1" }, { "db_name": "uniprot", "db_id": "Q15078" } ] }, { "id": "1.0alpha7.train.185.ent7_2", "type": "protein", "text": [ "p35" ], "offsets": [ [ 206, 209 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8851" }, { "db_name": "hgnc", "db_id": "CDK5R1" }, { "db_name": "uniprot", "db_id": "Q15078" } ] } ]

[]

[ { "id": "1.0alpha7.train.185.coref0", "entity_ids": [ "1.0alpha7.train.185.ent0_0" ] }, { "id": "1.0alpha7.train.185.coref1", "entity_ids": [ "1.0alpha7.train.185.ent1_0" ] }, { "id": "1.0alpha7.train.185.coref2", "entity_ids": [ "1.0alpha7.train.185.ent2_0" ] }, { "id": "1.0alpha7.train.185.coref3", "entity_ids": [ "1.0alpha7.train.185.ent3_0", "1.0alpha7.train.185.ent4_1" ] }, { "id": "1.0alpha7.train.185.coref4", "entity_ids": [ "1.0alpha7.train.185.ent5_0", "1.0alpha7.train.185.ent6_1", "1.0alpha7.train.185.ent7_2" ] } ]

[ { "id": "1.0alpha7.train.185.rel0s1.0alpha7.train.185.ent3_0.o1.0alpha7.train.185.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.185.ent3_0", "arg2_id": "1.0alpha7.train.185.ent5_0", "normalized": [] }, { "id": "1.0alpha7.train.185.rel0s1.0alpha7.train.185.ent3_0.o1.0alpha7.train.185.ent6_1", "type": "bind", "arg1_id": "1.0alpha7.train.185.ent3_0", "arg2_id": "1.0alpha7.train.185.ent6_1", "normalized": [] }, { "id": "1.0alpha7.train.185.rel0s1.0alpha7.train.185.ent3_0.o1.0alpha7.train.185.ent7_2", "type": "bind", "arg1_id": "1.0alpha7.train.185.ent3_0", "arg2_id": "1.0alpha7.train.185.ent7_2", "normalized": [] }, { "id": "1.0alpha7.train.185.rel0s1.0alpha7.train.185.ent4_1.o1.0alpha7.train.185.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.185.ent4_1", "arg2_id": "1.0alpha7.train.185.ent5_0", "normalized": [] }, { "id": "1.0alpha7.train.185.rel0s1.0alpha7.train.185.ent4_1.o1.0alpha7.train.185.ent6_1", "type": "bind", "arg1_id": "1.0alpha7.train.185.ent4_1", "arg2_id": "1.0alpha7.train.185.ent6_1", "normalized": [] }, { "id": "1.0alpha7.train.185.rel0s1.0alpha7.train.185.ent4_1.o1.0alpha7.train.185.ent7_2", "type": "bind", "arg1_id": "1.0alpha7.train.185.ent4_1", "arg2_id": "1.0alpha7.train.185.ent7_2", "normalized": [] } ]

[ { "id": "1.0alpha7.train.186.sent", "type": "sentence", "text": [ "It is clear, however, that only a small fraction of TLN binds PS1 under steady-state conditions (Figure 1E), indicating that the interaction is functional and not structural." ], "offsets": [ [ 0, 174 ] ] } ]

[ { "id": "1.0alpha7.train.186.ent0_0", "type": "protein", "text": [ "PS1" ], "offsets": [ [ 62, 65 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5663" }, { "db_name": "hgnc", "db_id": "PSEN1" }, { "db_name": "uniprot", "db_id": "P49768" } ] }, { "id": "1.0alpha7.train.186.ent1_0", "type": "protein", "text": [ "TLN" ], "offsets": [ [ 52, 55 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7094" }, { "db_name": "hgnc", "db_id": "TLN1" }, { "db_name": "uniprot", "db_id": "Q9Y490" } ] } ]

[]

[ { "id": "1.0alpha7.train.186.coref0", "entity_ids": [ "1.0alpha7.train.186.ent0_0" ] }, { "id": "1.0alpha7.train.186.coref1", "entity_ids": [ "1.0alpha7.train.186.ent1_0" ] } ]

[ { "id": "1.0alpha7.train.186.rel0s1.0alpha7.train.186.ent0_0.o1.0alpha7.train.186.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.186.ent0_0", "arg2_id": "1.0alpha7.train.186.ent1_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.187.sent", "type": "sentence", "text": [ "(C) Comparison of the binding of 10 JNK isoforms to JIP3." ], "offsets": [ [ 0, 57 ] ] } ]

[ { "id": "1.0alpha7.train.187.ent0_0", "type": "protein", "text": [ "JNK" ], "offsets": [ [ 36, 39 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5599" }, { "db_name": "hgnc", "db_id": "MAPK8" }, { "db_name": "uniprot", "db_id": "P45983" } ] }, { "id": "1.0alpha7.train.187.ent1_0", "type": "protein", "text": [ "JIP3" ], "offsets": [ [ 52, 56 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "23162" }, { "db_name": "hgnc", "db_id": "MAPK8IP3" }, { "db_name": "uniprot", "db_id": "Q9UPT6" } ] } ]

[]

[ { "id": "1.0alpha7.train.187.coref0", "entity_ids": [ "1.0alpha7.train.187.ent0_0" ] }, { "id": "1.0alpha7.train.187.coref1", "entity_ids": [ "1.0alpha7.train.187.ent1_0" ] } ]

[ { "id": "1.0alpha7.train.187.rel0s1.0alpha7.train.187.ent0_0.o1.0alpha7.train.187.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.187.ent0_0", "arg2_id": "1.0alpha7.train.187.ent1_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.188.sent", "type": "sentence", "text": [ "Despite a lack of significant sequence homology, the cadherin cytoplasmic domain, APC, and LEF/ Tcf bind competitively to beta-catenin (H&uuml ;lsken et al., 1994 ;." ], "offsets": [ [ 0, 165 ] ] } ]

[ { "id": "1.0alpha7.train.188.ent0_0", "type": "protein-family", "text": [ "cadherin" ], "offsets": [ [ 53, 61 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR039808" } ] }, { "id": "1.0alpha7.train.188.ent1_0", "type": "protein", "text": [ "APC" ], "offsets": [ [ 82, 85 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "324" }, { "db_name": "hgnc", "db_id": "APC" } ] }, { "id": "1.0alpha7.train.188.ent2_0", "type": "protein-family", "text": [ "LEF/ Tcf" ], "offsets": [ [ 91, 99 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR024940" } ] }, { "id": "1.0alpha7.train.188.ent3_0", "type": "protein", "text": [ "beta-catenin" ], "offsets": [ [ 122, 134 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1499" }, { "db_name": "hgnc", "db_id": "CTNNB1" }, { "db_name": "uniprot", "db_id": "P35222" } ] } ]

[]

[ { "id": "1.0alpha7.train.188.coref0", "entity_ids": [ "1.0alpha7.train.188.ent0_0" ] }, { "id": "1.0alpha7.train.188.coref1", "entity_ids": [ "1.0alpha7.train.188.ent1_0" ] }, { "id": "1.0alpha7.train.188.coref2", "entity_ids": [ "1.0alpha7.train.188.ent2_0" ] }, { "id": "1.0alpha7.train.188.coref3", "entity_ids": [ "1.0alpha7.train.188.ent3_0" ] } ]

[ { "id": "1.0alpha7.train.188.rel0s1.0alpha7.train.188.ent0_0.o1.0alpha7.train.188.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.188.ent0_0", "arg2_id": "1.0alpha7.train.188.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.188.rel1s1.0alpha7.train.188.ent1_0.o1.0alpha7.train.188.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.188.ent1_0", "arg2_id": "1.0alpha7.train.188.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.188.rel2s1.0alpha7.train.188.ent2_0.o1.0alpha7.train.188.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.188.ent2_0", "arg2_id": "1.0alpha7.train.188.ent3_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.189.sent", "type": "sentence", "text": [ "The binding of Hh to Ptc alleviates the repressive action of Ptc on Smo and, when Smo is derepressed, Ci proteolysis is inhibited and Ci is converted into a transcriptional activator." ], "offsets": [ [ 0, 183 ] ] } ]

[ { "id": "1.0alpha7.train.189.ent0_0", "type": "protein", "text": [ "Smo" ], "offsets": [ [ 68, 71 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6608" }, { "db_name": "hgnc", "db_id": "SMO" }, { "db_name": "uniprot", "db_id": "Q99835" } ] }, { "id": "1.0alpha7.train.189.ent1_1", "type": "protein", "text": [ "Smo" ], "offsets": [ [ 82, 85 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6608" }, { "db_name": "hgnc", "db_id": "SMO" }, { "db_name": "uniprot", "db_id": "Q99835" } ] }, { "id": "1.0alpha7.train.189.ent2_0", "type": "protein", "text": [ "Hh" ], "offsets": [ [ 15, 17 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q02936" } ] }, { "id": "1.0alpha7.train.189.ent3_0", "type": "protein", "text": [ "Ptc" ], "offsets": [ [ 21, 24 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P18502" } ] }, { "id": "1.0alpha7.train.189.ent4_1", "type": "protein", "text": [ "Ptc" ], "offsets": [ [ 61, 64 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P18502" } ] }, { "id": "1.0alpha7.train.189.ent5_0", "type": "protein", "text": [ "Ci" ], "offsets": [ [ 102, 104 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P19538" } ] }, { "id": "1.0alpha7.train.189.ent6_1", "type": "protein", "text": [ "Ci" ], "offsets": [ [ 134, 136 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P19538" } ] } ]

[]

[ { "id": "1.0alpha7.train.189.coref0", "entity_ids": [ "1.0alpha7.train.189.ent0_0", "1.0alpha7.train.189.ent1_1" ] }, { "id": "1.0alpha7.train.189.coref1", "entity_ids": [ "1.0alpha7.train.189.ent2_0" ] }, { "id": "1.0alpha7.train.189.coref2", "entity_ids": [ "1.0alpha7.train.189.ent3_0", "1.0alpha7.train.189.ent4_1" ] }, { "id": "1.0alpha7.train.189.coref3", "entity_ids": [ "1.0alpha7.train.189.ent5_0", "1.0alpha7.train.189.ent6_1" ] } ]

[ { "id": "1.0alpha7.train.189.rel0s1.0alpha7.train.189.ent2_0.o1.0alpha7.train.189.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.189.ent2_0", "arg2_id": "1.0alpha7.train.189.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.189.rel0s1.0alpha7.train.189.ent2_0.o1.0alpha7.train.189.ent4_1", "type": "bind", "arg1_id": "1.0alpha7.train.189.ent2_0", "arg2_id": "1.0alpha7.train.189.ent4_1", "normalized": [] } ]

[ { "id": "1.0alpha7.train.190.sent", "type": "sentence", "text": [ "Although the cooperativity of Arg binding to F-actin precluded an accurate determination of the dissociation constant of Arg for F-actin ( 19), the apparent Kd was 0.3 muM." ], "offsets": [ [ 0, 172 ] ] } ]

[ { "id": "1.0alpha7.train.190.ent0_0", "type": "protein", "text": [ "F-actin" ], "offsets": [ [ 45, 52 ] ], "normalized": [] }, { "id": "1.0alpha7.train.190.ent1_1", "type": "protein", "text": [ "F-actin" ], "offsets": [ [ 129, 136 ] ], "normalized": [] }, { "id": "1.0alpha7.train.190.ent2_0", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 47, 52 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] }, { "id": "1.0alpha7.train.190.ent3_1", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 131, 136 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] }, { "id": "1.0alpha7.train.190.ent4_0", "type": "protein", "text": [ "Arg" ], "offsets": [ [ 30, 33 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "27" }, { "db_name": "hgnc", "db_id": "ABL2" }, { "db_name": "uniprot", "db_id": "P42684" } ] }, { "id": "1.0alpha7.train.190.ent5_1", "type": "protein", "text": [ "Arg" ], "offsets": [ [ 121, 124 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "27" }, { "db_name": "hgnc", "db_id": "ABL2" }, { "db_name": "uniprot", "db_id": "P42684" } ] } ]

[]

[ { "id": "1.0alpha7.train.190.coref0", "entity_ids": [ "1.0alpha7.train.190.ent0_0", "1.0alpha7.train.190.ent1_1" ] }, { "id": "1.0alpha7.train.190.coref1", "entity_ids": [ "1.0alpha7.train.190.ent2_0", "1.0alpha7.train.190.ent3_1" ] }, { "id": "1.0alpha7.train.190.coref2", "entity_ids": [ "1.0alpha7.train.190.ent4_0", "1.0alpha7.train.190.ent5_1" ] } ]

[ { "id": "1.0alpha7.train.190.rel0s1.0alpha7.train.190.ent0_0.o1.0alpha7.train.190.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.190.ent0_0", "arg2_id": "1.0alpha7.train.190.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.190.rel0s1.0alpha7.train.190.ent0_0.o1.0alpha7.train.190.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.190.ent0_0", "arg2_id": "1.0alpha7.train.190.ent5_1", "normalized": [] }, { "id": "1.0alpha7.train.190.rel0s1.0alpha7.train.190.ent1_1.o1.0alpha7.train.190.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.190.ent1_1", "arg2_id": "1.0alpha7.train.190.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.190.rel0s1.0alpha7.train.190.ent1_1.o1.0alpha7.train.190.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.190.ent1_1", "arg2_id": "1.0alpha7.train.190.ent5_1", "normalized": [] } ]

[ { "id": "1.0alpha7.train.191.sent", "type": "sentence", "text": [ "Therefore, an initial recruitment of Sp1 may also facilitate the binding of Ets-1." ], "offsets": [ [ 0, 82 ] ] } ]

[ { "id": "1.0alpha7.train.191.ent0_0", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 37, 40 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.191.ent1_0", "type": "protein", "text": [ "Ets-1" ], "offsets": [ [ 76, 81 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2113" }, { "db_name": "hgnc", "db_id": "ETS1" }, { "db_name": "uniprot", "db_id": "P14921" } ] } ]

[]

[ { "id": "1.0alpha7.train.191.coref0", "entity_ids": [ "1.0alpha7.train.191.ent0_0" ] }, { "id": "1.0alpha7.train.191.coref1", "entity_ids": [ "1.0alpha7.train.191.ent1_0" ] } ]

[]

[ { "id": "1.0alpha7.train.192.sent", "type": "sentence", "text": [ "We examined whether the PTB domain of DAB could also bind to activated SEV." ], "offsets": [ [ 0, 75 ] ] } ]

[ { "id": "1.0alpha7.train.192.ent0_0", "type": "protein", "text": [ "SEV" ], "offsets": [ [ 71, 74 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P13368" } ] }, { "id": "1.0alpha7.train.192.ent1_0", "type": "protein-domain", "text": [ "PTB domain" ], "offsets": [ [ 24, 34 ] ], "normalized": [] }, { "id": "1.0alpha7.train.192.ent2_0", "type": "protein", "text": [ "DAB" ], "offsets": [ [ 38, 41 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P98081" } ] } ]

[]

[ { "id": "1.0alpha7.train.192.coref0", "entity_ids": [ "1.0alpha7.train.192.ent0_0" ] }, { "id": "1.0alpha7.train.192.coref1", "entity_ids": [ "1.0alpha7.train.192.ent1_0" ] }, { "id": "1.0alpha7.train.192.coref2", "entity_ids": [ "1.0alpha7.train.192.ent2_0" ] } ]

[ { "id": "1.0alpha7.train.192.rel0s1.0alpha7.train.192.ent0_0.o1.0alpha7.train.192.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.192.ent0_0", "arg2_id": "1.0alpha7.train.192.ent2_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.193.sent", "type": "sentence", "text": [ "Such a scenario has been documented for the JNK MAP kinases bound to c-Jun, which can phosphorylate heterodimer partners that lack a JNK-binding site ( 29)." ], "offsets": [ [ 0, 156 ] ] } ]

[ { "id": "1.0alpha7.train.193.ent0_0", "type": "protein-family", "text": [ "JNK MAP kinases" ], "offsets": [ [ 44, 59 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR008351" } ] }, { "id": "1.0alpha7.train.193.ent1_0", "type": "protein", "text": [ "c-Jun" ], "offsets": [ [ 69, 74 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3725" }, { "db_name": "hgnc", "db_id": "JUN" }, { "db_name": "uniprot", "db_id": "P05412" } ] } ]

[]

[ { "id": "1.0alpha7.train.193.coref0", "entity_ids": [ "1.0alpha7.train.193.ent0_0" ] }, { "id": "1.0alpha7.train.193.coref1", "entity_ids": [ "1.0alpha7.train.193.ent1_0" ] } ]

[ { "id": "1.0alpha7.train.193.rel0s1.0alpha7.train.193.ent0_0.o1.0alpha7.train.193.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.193.ent0_0", "arg2_id": "1.0alpha7.train.193.ent1_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.194.sent", "type": "sentence", "text": [ "The data presented in this study clearly show that I-DOX binds specifically to TTR amyloid fibrils in tissues from patients with FAP." ], "offsets": [ [ 0, 133 ] ] } ]

[ { "id": "1.0alpha7.train.194.ent0_0", "type": "protein", "text": [ "TTR" ], "offsets": [ [ 79, 82 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7276" }, { "db_name": "hgnc", "db_id": "TTR" }, { "db_name": "uniprot", "db_id": "P02766" } ] }, { "id": "1.0alpha7.train.194.ent1_0", "type": "chemical", "text": [ "I-DOX" ], "offsets": [ [ 51, 56 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "108161" } ] }, { "id": "1.0alpha7.train.194.ent2_0", "type": "disease", "text": [ "FAP" ], "offsets": [ [ 129, 132 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.194.coref0", "entity_ids": [ "1.0alpha7.train.194.ent0_0" ] }, { "id": "1.0alpha7.train.194.coref1", "entity_ids": [ "1.0alpha7.train.194.ent1_0" ] }, { "id": "1.0alpha7.train.194.coref2", "entity_ids": [ "1.0alpha7.train.194.ent2_0" ] } ]

[ { "id": "1.0alpha7.train.194.rel0s1.0alpha7.train.194.ent0_0.o1.0alpha7.train.194.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.194.ent0_0", "arg2_id": "1.0alpha7.train.194.ent1_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.195.sent", "type": "sentence", "text": [ "When sal-Gal4 was used to drive ectopic expression of E(spl)Mβ in the wing imaginal disc, Gbe-B1-lacZ was clearly repressed at the sites where Gal4, and thus Mβ, was being expressed at highest levels (Fig. ​6A and B), demonstrating that E(spl)bHLH proteins can bind the B1 site and repress transcription in vivo." ], "offsets": [ [ 0, 312 ] ] } ]

[ { "id": "1.0alpha7.train.195.ent0_0", "type": "experiment-tag", "text": [ "Gal4" ], "offsets": [ [ 9, 13 ] ], "normalized": [] }, { "id": "1.0alpha7.train.195.ent1_1", "type": "experiment-tag", "text": [ "Gal4" ], "offsets": [ [ 143, 147 ] ], "normalized": [] }, { "id": "1.0alpha7.train.195.ent2_0", "type": "protein", "text": [ "E(spl)Mβ" ], "offsets": [ [ 54, 62 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q01069" } ] }, { "id": "1.0alpha7.train.195.ent3_0", "type": "protein", "text": [ "Mβ" ], "offsets": [ [ 60, 62 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q01069" } ] }, { "id": "1.0alpha7.train.195.ent4_1", "type": "protein", "text": [ "Mβ" ], "offsets": [ [ 158, 160 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q01069" } ] }, { "id": "1.0alpha7.train.195.ent5_0", "type": "experiment-tag", "text": [ "Gbe" ], "offsets": [ [ 90, 93 ] ], "normalized": [] }, { "id": "1.0alpha7.train.195.ent6_0", "type": "DNA", "text": [ "B1 site" ], "offsets": [ [ 270, 277 ] ], "normalized": [] }, { "id": "1.0alpha7.train.195.ent7_0", "type": "protein", "text": [ "E(spl)bHLH" ], "offsets": [ [ 237, 247 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q01069" } ] }, { "id": "1.0alpha7.train.195.ent8_0", "type": "experimental-construct", "text": [ "Gbe-B1-lacZ" ], "offsets": [ [ 90, 101 ] ], "normalized": [] }, { "id": "1.0alpha7.train.195.ent9_0", "type": "experiment-tag", "text": [ "lacZ" ], "offsets": [ [ 97, 101 ] ], "normalized": [] }, { "id": "1.0alpha7.train.195.ent10_0", "type": "experimental-construct", "text": [ "sal-Gal4" ], "offsets": [ [ 5, 13 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.195.coref0", "entity_ids": [ "1.0alpha7.train.195.ent0_0", "1.0alpha7.train.195.ent1_1" ] }, { "id": "1.0alpha7.train.195.coref1", "entity_ids": [ "1.0alpha7.train.195.ent2_0", "1.0alpha7.train.195.ent3_0", "1.0alpha7.train.195.ent4_1" ] }, { "id": "1.0alpha7.train.195.coref2", "entity_ids": [ "1.0alpha7.train.195.ent5_0" ] }, { "id": "1.0alpha7.train.195.coref3", "entity_ids": [ "1.0alpha7.train.195.ent6_0" ] }, { "id": "1.0alpha7.train.195.coref4", "entity_ids": [ "1.0alpha7.train.195.ent7_0" ] }, { "id": "1.0alpha7.train.195.coref5", "entity_ids": [ "1.0alpha7.train.195.ent8_0" ] }, { "id": "1.0alpha7.train.195.coref6", "entity_ids": [ "1.0alpha7.train.195.ent9_0" ] }, { "id": "1.0alpha7.train.195.coref7", "entity_ids": [ "1.0alpha7.train.195.ent10_0" ] } ]

[ { "id": "1.0alpha7.train.195.rel0s1.0alpha7.train.195.ent6_0.o1.0alpha7.train.195.ent7_0", "type": "bind", "arg1_id": "1.0alpha7.train.195.ent6_0", "arg2_id": "1.0alpha7.train.195.ent7_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.196.sent", "type": "sentence", "text": [ "Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain." ], "offsets": [ [ 0, 92 ] ] } ]

[ { "id": "1.0alpha7.train.196.ent0_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 36, 39 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.196.ent1_0", "type": "protein", "text": [ "p53" ], "offsets": [ [ 14, 17 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7157" }, { "db_name": "hgnc", "db_id": "TP53" }, { "db_name": "uniprot", "db_id": "P04637" } ] }, { "id": "1.0alpha7.train.196.ent2_1", "type": "protein", "text": [ "p53" ], "offsets": [ [ 70, 73 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7157" }, { "db_name": "hgnc", "db_id": "TP53" }, { "db_name": "uniprot", "db_id": "P04637" } ] } ]

[]

[ { "id": "1.0alpha7.train.196.coref0", "entity_ids": [ "1.0alpha7.train.196.ent0_0" ] }, { "id": "1.0alpha7.train.196.coref1", "entity_ids": [ "1.0alpha7.train.196.ent1_0", "1.0alpha7.train.196.ent2_1" ] } ]

[ { "id": "1.0alpha7.train.196.rel0s1.0alpha7.train.196.ent0_0.o1.0alpha7.train.196.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.196.ent0_0", "arg2_id": "1.0alpha7.train.196.ent1_0", "normalized": [] }, { "id": "1.0alpha7.train.196.rel0s1.0alpha7.train.196.ent0_0.o1.0alpha7.train.196.ent2_1", "type": "bind", "arg1_id": "1.0alpha7.train.196.ent0_0", "arg2_id": "1.0alpha7.train.196.ent2_1", "normalized": [] } ]

[ { "id": "1.0alpha7.train.197.sent", "type": "sentence", "text": [ "Therefore, binding of the TGFβ family type I receptors and the huge IP3 receptor to the FK506 binding site of FKBP12 suggests that calcineurin, if also directly bound to FKBP12 in the receptor/FKBP12/calcineurin complex, must be binding to sites removed from the FK506 binding site of FKBP12." ], "offsets": [ [ 0, 292 ] ] } ]

[ { "id": "1.0alpha7.train.197.ent0_0", "type": "protein", "text": [ "calcineurin" ], "offsets": [ [ 131, 142 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5530" }, { "db_name": "hgnc", "db_id": "PPP3CA" }, { "db_name": "uniprot", "db_id": "Q08209" } ] }, { "id": "1.0alpha7.train.197.ent1_1", "type": "protein", "text": [ "calcineurin" ], "offsets": [ [ 200, 211 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5530" }, { "db_name": "hgnc", "db_id": "PPP3CA" }, { "db_name": "uniprot", "db_id": "Q08209" } ] }, { "id": "1.0alpha7.train.197.ent2_0", "type": "protein-family", "text": [ "TGFβ family type I receptors" ], "offsets": [ [ 26, 54 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR000333" } ] }, { "id": "1.0alpha7.train.197.ent3_0", "type": "protein-complex", "text": [ "receptor/FKBP12/calcineurin" ], "offsets": [ [ 184, 211 ] ], "normalized": [] }, { "id": "1.0alpha7.train.197.ent4_0", "type": "chemical", "text": [ "FK506" ], "offsets": [ [ 88, 93 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "445643" } ] }, { "id": "1.0alpha7.train.197.ent5_1", "type": "chemical", "text": [ "FK506" ], "offsets": [ [ 263, 268 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "445643" } ] }, { "id": "1.0alpha7.train.197.ent6_0", "type": "protein", "text": [ "IP3 receptor" ], "offsets": [ [ 68, 80 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3708" }, { "db_name": "hgnc", "db_id": "ITPR1" }, { "db_name": "uniprot", "db_id": "Q14643" } ] }, { "id": "1.0alpha7.train.197.ent7_0", "type": "protein", "text": [ "FKBP12" ], "offsets": [ [ 110, 116 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2280" }, { "db_name": "hgnc", "db_id": "FKBP1A" }, { "db_name": "uniprot", "db_id": "P62942" } ] }, { "id": "1.0alpha7.train.197.ent8_1", "type": "protein", "text": [ "FKBP12" ], "offsets": [ [ 170, 176 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2280" }, { "db_name": "hgnc", "db_id": "FKBP1A" }, { "db_name": "uniprot", "db_id": "P62942" } ] }, { "id": "1.0alpha7.train.197.ent9_2", "type": "protein", "text": [ "FKBP12" ], "offsets": [ [ 193, 199 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2280" }, { "db_name": "hgnc", "db_id": "FKBP1A" }, { "db_name": "uniprot", "db_id": "P62942" } ] }, { "id": "1.0alpha7.train.197.ent10_3", "type": "protein", "text": [ "FKBP12" ], "offsets": [ [ 285, 291 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2280" }, { "db_name": "hgnc", "db_id": "FKBP1A" }, { "db_name": "uniprot", "db_id": "P62942" } ] } ]

[]

[ { "id": "1.0alpha7.train.197.coref0", "entity_ids": [ "1.0alpha7.train.197.ent0_0", "1.0alpha7.train.197.ent1_1" ] }, { "id": "1.0alpha7.train.197.coref1", "entity_ids": [ "1.0alpha7.train.197.ent2_0" ] }, { "id": "1.0alpha7.train.197.coref2", "entity_ids": [ "1.0alpha7.train.197.ent3_0" ] }, { "id": "1.0alpha7.train.197.coref3", "entity_ids": [ "1.0alpha7.train.197.ent4_0", "1.0alpha7.train.197.ent5_1" ] }, { "id": "1.0alpha7.train.197.coref4", "entity_ids": [ "1.0alpha7.train.197.ent6_0" ] }, { "id": "1.0alpha7.train.197.coref5", "entity_ids": [ "1.0alpha7.train.197.ent7_0", "1.0alpha7.train.197.ent8_1", "1.0alpha7.train.197.ent9_2", "1.0alpha7.train.197.ent10_3" ] } ]

[ { "id": "1.0alpha7.train.197.rel0s1.0alpha7.train.197.ent4_0.o1.0alpha7.train.197.ent7_0", "type": "bind", "arg1_id": "1.0alpha7.train.197.ent4_0", "arg2_id": "1.0alpha7.train.197.ent7_0", "normalized": [] }, { "id": "1.0alpha7.train.197.rel0s1.0alpha7.train.197.ent4_0.o1.0alpha7.train.197.ent8_1", "type": "bind", "arg1_id": "1.0alpha7.train.197.ent4_0", "arg2_id": "1.0alpha7.train.197.ent8_1", "normalized": [] }, { "id": "1.0alpha7.train.197.rel0s1.0alpha7.train.197.ent4_0.o1.0alpha7.train.197.ent9_2", "type": "bind", "arg1_id": "1.0alpha7.train.197.ent4_0", "arg2_id": "1.0alpha7.train.197.ent9_2", "normalized": [] }, { "id": "1.0alpha7.train.197.rel0s1.0alpha7.train.197.ent4_0.o1.0alpha7.train.197.ent10_3", "type": "bind", "arg1_id": "1.0alpha7.train.197.ent4_0", "arg2_id": "1.0alpha7.train.197.ent10_3", "normalized": [] }, { "id": "1.0alpha7.train.197.rel0s1.0alpha7.train.197.ent5_1.o1.0alpha7.train.197.ent7_0", "type": "bind", "arg1_id": "1.0alpha7.train.197.ent5_1", "arg2_id": "1.0alpha7.train.197.ent7_0", "normalized": [] }, { "id": "1.0alpha7.train.197.rel0s1.0alpha7.train.197.ent5_1.o1.0alpha7.train.197.ent8_1", "type": "bind", "arg1_id": "1.0alpha7.train.197.ent5_1", "arg2_id": "1.0alpha7.train.197.ent8_1", "normalized": [] }, { "id": "1.0alpha7.train.197.rel0s1.0alpha7.train.197.ent5_1.o1.0alpha7.train.197.ent9_2", "type": "bind", "arg1_id": "1.0alpha7.train.197.ent5_1", "arg2_id": "1.0alpha7.train.197.ent9_2", "normalized": [] }, { "id": "1.0alpha7.train.197.rel0s1.0alpha7.train.197.ent5_1.o1.0alpha7.train.197.ent10_3", "type": "bind", "arg1_id": "1.0alpha7.train.197.ent5_1", "arg2_id": "1.0alpha7.train.197.ent10_3", "normalized": [] }, { "id": "1.0alpha7.train.197.rel1s1.0alpha7.train.197.ent0_0.o1.0alpha7.train.197.ent7_0", "type": "bind", "arg1_id": "1.0alpha7.train.197.ent0_0", "arg2_id": "1.0alpha7.train.197.ent7_0", "normalized": [] }, { "id": "1.0alpha7.train.197.rel1s1.0alpha7.train.197.ent0_0.o1.0alpha7.train.197.ent8_1", "type": "bind", "arg1_id": "1.0alpha7.train.197.ent0_0", "arg2_id": "1.0alpha7.train.197.ent8_1", "normalized": [] }, { "id": "1.0alpha7.train.197.rel1s1.0alpha7.train.197.ent0_0.o1.0alpha7.train.197.ent9_2", "type": "bind", "arg1_id": "1.0alpha7.train.197.ent0_0", "arg2_id": "1.0alpha7.train.197.ent9_2", "normalized": [] }, { "id": "1.0alpha7.train.197.rel1s1.0alpha7.train.197.ent0_0.o1.0alpha7.train.197.ent10_3", "type": "bind", "arg1_id": "1.0alpha7.train.197.ent0_0", "arg2_id": "1.0alpha7.train.197.ent10_3", "normalized": [] }, { "id": "1.0alpha7.train.197.rel1s1.0alpha7.train.197.ent1_1.o1.0alpha7.train.197.ent7_0", "type": "bind", "arg1_id": "1.0alpha7.train.197.ent1_1", "arg2_id": "1.0alpha7.train.197.ent7_0", "normalized": [] }, { "id": "1.0alpha7.train.197.rel1s1.0alpha7.train.197.ent1_1.o1.0alpha7.train.197.ent8_1", "type": "bind", "arg1_id": "1.0alpha7.train.197.ent1_1", "arg2_id": "1.0alpha7.train.197.ent8_1", "normalized": [] }, { "id": "1.0alpha7.train.197.rel1s1.0alpha7.train.197.ent1_1.o1.0alpha7.train.197.ent9_2", "type": "bind", "arg1_id": "1.0alpha7.train.197.ent1_1", "arg2_id": "1.0alpha7.train.197.ent9_2", "normalized": [] }, { "id": "1.0alpha7.train.197.rel1s1.0alpha7.train.197.ent1_1.o1.0alpha7.train.197.ent10_3", "type": "bind", "arg1_id": "1.0alpha7.train.197.ent1_1", "arg2_id": "1.0alpha7.train.197.ent10_3", "normalized": [] } ]

[ { "id": "1.0alpha7.train.198.sent", "type": "sentence", "text": [ "In favor of a role for cytochrome c is the fact that Dark contains, like Apaf-1 but in contrast to Ced-4, a carboxy-terminal WD-40 repeat region, which is required though not sufficient for the binding of cytochrome c to Apaf-1 (see references in [ 37])." ], "offsets": [ [ 0, 254 ] ] } ]

[ { "id": "1.0alpha7.train.198.ent0_0", "type": "protein", "text": [ "Dark" ], "offsets": [ [ 53, 57 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q7KLI1" } ] }, { "id": "1.0alpha7.train.198.ent1_0", "type": "protein", "text": [ "cytochrome c" ], "offsets": [ [ 23, 35 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P04657" } ] }, { "id": "1.0alpha7.train.198.ent2_1", "type": "protein", "text": [ "cytochrome c" ], "offsets": [ [ 205, 217 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P04657" } ] }, { "id": "1.0alpha7.train.198.ent3_0", "type": "protein-motif", "text": [ "WD-40 repeat" ], "offsets": [ [ 125, 137 ] ], "normalized": [] }, { "id": "1.0alpha7.train.198.ent4_0", "type": "protein", "text": [ "Apaf-1" ], "offsets": [ [ 73, 79 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q7KLI1" } ] }, { "id": "1.0alpha7.train.198.ent5_1", "type": "protein", "text": [ "Apaf-1" ], "offsets": [ [ 221, 227 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q7KLI1" } ] }, { "id": "1.0alpha7.train.198.ent6_0", "type": "protein", "text": [ "Ced-4" ], "offsets": [ [ 99, 104 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.198.coref0", "entity_ids": [ "1.0alpha7.train.198.ent0_0" ] }, { "id": "1.0alpha7.train.198.coref1", "entity_ids": [ "1.0alpha7.train.198.ent1_0", "1.0alpha7.train.198.ent2_1" ] }, { "id": "1.0alpha7.train.198.coref2", "entity_ids": [ "1.0alpha7.train.198.ent3_0" ] }, { "id": "1.0alpha7.train.198.coref3", "entity_ids": [ "1.0alpha7.train.198.ent4_0", "1.0alpha7.train.198.ent5_1" ] }, { "id": "1.0alpha7.train.198.coref4", "entity_ids": [ "1.0alpha7.train.198.ent6_0" ] } ]

[ { "id": "1.0alpha7.train.198.rel0s1.0alpha7.train.198.ent1_0.o1.0alpha7.train.198.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.198.ent1_0", "arg2_id": "1.0alpha7.train.198.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.198.rel0s1.0alpha7.train.198.ent1_0.o1.0alpha7.train.198.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.198.ent1_0", "arg2_id": "1.0alpha7.train.198.ent5_1", "normalized": [] }, { "id": "1.0alpha7.train.198.rel0s1.0alpha7.train.198.ent2_1.o1.0alpha7.train.198.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.198.ent2_1", "arg2_id": "1.0alpha7.train.198.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.198.rel0s1.0alpha7.train.198.ent2_1.o1.0alpha7.train.198.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.198.ent2_1", "arg2_id": "1.0alpha7.train.198.ent5_1", "normalized": [] } ]

[ { "id": "1.0alpha7.train.199.sent", "type": "sentence", "text": [ "Deletion experiments suggest that these regions, as well as the C- and N-termini, are vital for forming the proper homotrimeric, native structure essential for the binding of PCNA to its target proteins ( Fukuda et al., 1995; Fein and Stillman, 1992)." ], "offsets": [ [ 0, 251 ] ] } ]

[ { "id": "1.0alpha7.train.199.ent0_0", "type": "protein", "text": [ "PCNA" ], "offsets": [ [ 175, 179 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5111" }, { "db_name": "hgnc", "db_id": "PCNA" }, { "db_name": "uniprot", "db_id": "P12004" } ] } ]

[]

[ { "id": "1.0alpha7.train.199.coref0", "entity_ids": [ "1.0alpha7.train.199.ent0_0" ] } ]

[]

[ { "id": "1.0alpha7.train.200.sent", "type": "sentence", "text": [ "Furthermore, G6P binding to GS induces a conformational change, increasing its susceptibility to dephosphorylation ( 5, 6)." ], "offsets": [ [ 0, 123 ] ] } ]

[ { "id": "1.0alpha7.train.200.ent0_0", "type": "protein-family", "text": [ "G6P" ], "offsets": [ [ 13, 16 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR016275" } ] }, { "id": "1.0alpha7.train.200.ent1_0", "type": "protein-family", "text": [ "GS" ], "offsets": [ [ 28, 30 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR003605" } ] } ]

[]

[ { "id": "1.0alpha7.train.200.coref0", "entity_ids": [ "1.0alpha7.train.200.ent0_0" ] }, { "id": "1.0alpha7.train.200.coref1", "entity_ids": [ "1.0alpha7.train.200.ent1_0" ] } ]

[ { "id": "1.0alpha7.train.200.rel0s1.0alpha7.train.200.ent0_0.o1.0alpha7.train.200.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.200.ent0_0", "arg2_id": "1.0alpha7.train.200.ent1_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.201.sent", "type": "sentence", "text": [ "(A) The peptide analogous to the wild-type N terminus of KCNK9 (and KCNK3) binds beta-COP from rat brain, while peptides with the NQ mutation do not (left)." ], "offsets": [ [ 0, 156 ] ] } ]

[ { "id": "1.0alpha7.train.201.ent0_0", "type": "protein", "text": [ "beta-COP" ], "offsets": [ [ 81, 89 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1315" }, { "db_name": "hgnc", "db_id": "COPB1" }, { "db_name": "uniprot", "db_id": "P53618" } ] }, { "id": "1.0alpha7.train.201.ent1_0", "type": "protein", "text": [ "KCNK9" ], "offsets": [ [ 57, 62 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "51305" }, { "db_name": "hgnc", "db_id": "KCNK9" }, { "db_name": "uniprot", "db_id": "Q9NPC2" } ] }, { "id": "1.0alpha7.train.201.ent2_0", "type": "protein", "text": [ "KCNK3" ], "offsets": [ [ 68, 73 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3777" }, { "db_name": "hgnc", "db_id": "KCNK3" } ] } ]

[]

[ { "id": "1.0alpha7.train.201.coref0", "entity_ids": [ "1.0alpha7.train.201.ent0_0" ] }, { "id": "1.0alpha7.train.201.coref1", "entity_ids": [ "1.0alpha7.train.201.ent1_0" ] }, { "id": "1.0alpha7.train.201.coref2", "entity_ids": [ "1.0alpha7.train.201.ent2_0" ] } ]

[ { "id": "1.0alpha7.train.201.rel0s1.0alpha7.train.201.ent0_0.o1.0alpha7.train.201.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.201.ent0_0", "arg2_id": "1.0alpha7.train.201.ent1_0", "normalized": [] }, { "id": "1.0alpha7.train.201.rel1s1.0alpha7.train.201.ent0_0.o1.0alpha7.train.201.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.201.ent0_0", "arg2_id": "1.0alpha7.train.201.ent2_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.202.sent", "type": "sentence", "text": [ "On the other hand, the SH2 domain of Crk can potentially bind to both p130Cas and paxillin." ], "offsets": [ [ 0, 91 ] ] } ]

[ { "id": "1.0alpha7.train.202.ent0_0", "type": "protein", "text": [ "Crk" ], "offsets": [ [ 37, 40 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1398" }, { "db_name": "hgnc", "db_id": "CRK" }, { "db_name": "uniprot", "db_id": "P46108" } ] }, { "id": "1.0alpha7.train.202.ent1_0", "type": "protein", "text": [ "p130Cas" ], "offsets": [ [ 70, 77 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "9564" }, { "db_name": "hgnc", "db_id": "BCAR1" }, { "db_name": "uniprot", "db_id": "P56945" } ] }, { "id": "1.0alpha7.train.202.ent2_0", "type": "protein-domain", "text": [ "SH2 domain" ], "offsets": [ [ 23, 33 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR000980" } ] }, { "id": "1.0alpha7.train.202.ent3_0", "type": "protein", "text": [ "paxillin" ], "offsets": [ [ 82, 90 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5829" }, { "db_name": "hgnc", "db_id": "PXN" }, { "db_name": "uniprot", "db_id": "P49023" } ] } ]

[]

[ { "id": "1.0alpha7.train.202.coref0", "entity_ids": [ "1.0alpha7.train.202.ent0_0" ] }, { "id": "1.0alpha7.train.202.coref1", "entity_ids": [ "1.0alpha7.train.202.ent1_0" ] }, { "id": "1.0alpha7.train.202.coref2", "entity_ids": [ "1.0alpha7.train.202.ent2_0" ] }, { "id": "1.0alpha7.train.202.coref3", "entity_ids": [ "1.0alpha7.train.202.ent3_0" ] } ]

[ { "id": "1.0alpha7.train.202.rel0s1.0alpha7.train.202.ent0_0.o1.0alpha7.train.202.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.202.ent0_0", "arg2_id": "1.0alpha7.train.202.ent1_0", "normalized": [] }, { "id": "1.0alpha7.train.202.rel1s1.0alpha7.train.202.ent0_0.o1.0alpha7.train.202.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.202.ent0_0", "arg2_id": "1.0alpha7.train.202.ent3_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.203.sent", "type": "sentence", "text": [ "TAFII250 binds directly to TBP and multiple other TAFIIs, thus serving as a potential scaffold for the multiprotein complex ( 28, 29)." ], "offsets": [ [ 0, 134 ] ] } ]

[ { "id": "1.0alpha7.train.203.ent0_0", "type": "protein", "text": [ "TAFII250" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P51123" } ] }, { "id": "1.0alpha7.train.203.ent1_0", "type": "protein", "text": [ "TBP" ], "offsets": [ [ 27, 30 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6908" }, { "db_name": "hgnc", "db_id": "TBP" }, { "db_name": "uniprot", "db_id": "P20226" } ] }, { "id": "1.0alpha7.train.203.ent2_0", "type": "protein-family", "text": [ "TAFIIs" ], "offsets": [ [ 50, 56 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR004823" } ] } ]

[]

[ { "id": "1.0alpha7.train.203.coref0", "entity_ids": [ "1.0alpha7.train.203.ent0_0" ] }, { "id": "1.0alpha7.train.203.coref1", "entity_ids": [ "1.0alpha7.train.203.ent1_0" ] }, { "id": "1.0alpha7.train.203.coref2", "entity_ids": [ "1.0alpha7.train.203.ent2_0" ] } ]

[ { "id": "1.0alpha7.train.203.rel0s1.0alpha7.train.203.ent0_0.o1.0alpha7.train.203.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.203.ent0_0", "arg2_id": "1.0alpha7.train.203.ent1_0", "normalized": [] }, { "id": "1.0alpha7.train.203.rel1s1.0alpha7.train.203.ent0_0.o1.0alpha7.train.203.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.203.ent0_0", "arg2_id": "1.0alpha7.train.203.ent2_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.204.sent", "type": "sentence", "text": [ "Since TSA induced Sp1 binding to Sp1 consensus sequences in Hep3B cells, we investigated whether TSA affected Sp1 phosphorylation, a possible cause for the increase of Sp1 binding to its consensus DNA sequences." ], "offsets": [ [ 0, 211 ] ] } ]

[ { "id": "1.0alpha7.train.204.ent0_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 197, 200 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.204.ent1_0", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 18, 21 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.204.ent2_1", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 33, 36 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.204.ent3_2", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 110, 113 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.204.ent4_3", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 168, 171 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.204.ent5_0", "type": "DNA", "text": [ "Sp1 consensus sequences" ], "offsets": [ [ 33, 56 ] ], "normalized": [] }, { "id": "1.0alpha7.train.204.ent6_0", "type": "cell", "text": [ "Hep3B cells" ], "offsets": [ [ 60, 71 ] ], "normalized": [] }, { "id": "1.0alpha7.train.204.ent7_0", "type": "chemical", "text": [ "TSA" ], "offsets": [ [ 6, 9 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "444732" } ] }, { "id": "1.0alpha7.train.204.ent8_1", "type": "chemical", "text": [ "TSA" ], "offsets": [ [ 97, 100 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "444732" } ] } ]

[]

[ { "id": "1.0alpha7.train.204.coref0", "entity_ids": [ "1.0alpha7.train.204.ent0_0" ] }, { "id": "1.0alpha7.train.204.coref1", "entity_ids": [ "1.0alpha7.train.204.ent1_0", "1.0alpha7.train.204.ent2_1", "1.0alpha7.train.204.ent3_2", "1.0alpha7.train.204.ent4_3" ] }, { "id": "1.0alpha7.train.204.coref2", "entity_ids": [ "1.0alpha7.train.204.ent5_0" ] }, { "id": "1.0alpha7.train.204.coref3", "entity_ids": [ "1.0alpha7.train.204.ent6_0" ] }, { "id": "1.0alpha7.train.204.coref4", "entity_ids": [ "1.0alpha7.train.204.ent7_0", "1.0alpha7.train.204.ent8_1" ] } ]

[ { "id": "1.0alpha7.train.204.rel0s1.0alpha7.train.204.ent1_0.o1.0alpha7.train.204.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.204.ent1_0", "arg2_id": "1.0alpha7.train.204.ent5_0", "normalized": [] }, { "id": "1.0alpha7.train.204.rel0s1.0alpha7.train.204.ent2_1.o1.0alpha7.train.204.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.204.ent2_1", "arg2_id": "1.0alpha7.train.204.ent5_0", "normalized": [] }, { "id": "1.0alpha7.train.204.rel0s1.0alpha7.train.204.ent3_2.o1.0alpha7.train.204.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.204.ent3_2", "arg2_id": "1.0alpha7.train.204.ent5_0", "normalized": [] }, { "id": "1.0alpha7.train.204.rel0s1.0alpha7.train.204.ent4_3.o1.0alpha7.train.204.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.204.ent4_3", "arg2_id": "1.0alpha7.train.204.ent5_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.205.sent", "type": "sentence", "text": [ "Systemic administration of 3-NPA (30 mg kg-1 per day for 3 days) induced a 170% increase in [3]- PK 11195 binding, and expression of HSP27." ], "offsets": [ [ 0, 139 ] ] } ]

[ { "id": "1.0alpha7.train.205.ent0_0", "type": "protein", "text": [ "HSP27" ], "offsets": [ [ 133, 138 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3315" }, { "db_name": "hgnc", "db_id": "HSPB1" }, { "db_name": "uniprot", "db_id": "P04792" } ] }, { "id": "1.0alpha7.train.205.ent1_0", "type": "chemical", "text": [ "[3]- PK 11195" ], "offsets": [ [ 92, 105 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "1345" } ] }, { "id": "1.0alpha7.train.205.ent2_0", "type": "chemical", "text": [ "3-NPA" ], "offsets": [ [ 27, 32 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "1678" } ] } ]

[]

[ { "id": "1.0alpha7.train.205.coref0", "entity_ids": [ "1.0alpha7.train.205.ent0_0" ] }, { "id": "1.0alpha7.train.205.coref1", "entity_ids": [ "1.0alpha7.train.205.ent1_0" ] }, { "id": "1.0alpha7.train.205.coref2", "entity_ids": [ "1.0alpha7.train.205.ent2_0" ] } ]

[]

[ { "id": "1.0alpha7.train.206.sent", "type": "sentence", "text": [ "This interpretation is consistent with stopped flow experiments on the formation of the catalytic complex, which were interpreted as evidence that the second dIII binds to the dI dimer with a Kd of 20-50 M [ 24]." ], "offsets": [ [ 0, 212 ] ] } ]

[ { "id": "1.0alpha7.train.206.ent0_0", "type": "protein", "text": [ "dI" ], "offsets": [ [ 176, 178 ] ], "normalized": [] }, { "id": "1.0alpha7.train.206.ent1_0", "type": "protein", "text": [ "dIII" ], "offsets": [ [ 158, 162 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.206.coref0", "entity_ids": [ "1.0alpha7.train.206.ent0_0" ] }, { "id": "1.0alpha7.train.206.coref1", "entity_ids": [ "1.0alpha7.train.206.ent1_0" ] } ]

[ { "id": "1.0alpha7.train.206.rel0s1.0alpha7.train.206.ent0_0.o1.0alpha7.train.206.ent0_0", "type": "bind", "arg1_id": "1.0alpha7.train.206.ent0_0", "arg2_id": "1.0alpha7.train.206.ent0_0", "normalized": [] }, { "id": "1.0alpha7.train.206.rel1s1.0alpha7.train.206.ent0_0.o1.0alpha7.train.206.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.206.ent0_0", "arg2_id": "1.0alpha7.train.206.ent1_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.207.sent", "type": "sentence", "text": [ "75 89 90 91 Two of them, A63V and K70T, are located in exon 2b within the consensus pattern of sequence repeats of alpha-TM and could alter tropomyosin binding to actin." ], "offsets": [ [ 0, 169 ] ] } ]

[ { "id": "1.0alpha7.train.207.ent0_0", "type": "protein-family", "text": [ "alpha-TM" ], "offsets": [ [ 115, 123 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00261" } ] }, { "id": "1.0alpha7.train.207.ent1_0", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 163, 168 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] }, { "id": "1.0alpha7.train.207.ent2_0", "type": "protein-family", "text": [ "tropomyosin" ], "offsets": [ [ 140, 151 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00261" } ] } ]

[]

[ { "id": "1.0alpha7.train.207.coref0", "entity_ids": [ "1.0alpha7.train.207.ent0_0" ] }, { "id": "1.0alpha7.train.207.coref1", "entity_ids": [ "1.0alpha7.train.207.ent1_0" ] }, { "id": "1.0alpha7.train.207.coref2", "entity_ids": [ "1.0alpha7.train.207.ent2_0" ] } ]

[ { "id": "1.0alpha7.train.207.rel0s1.0alpha7.train.207.ent1_0.o1.0alpha7.train.207.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.207.ent1_0", "arg2_id": "1.0alpha7.train.207.ent2_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.208.sent", "type": "sentence", "text": [ "The majority of gp160 remained bound to calreticulin despite addition of ATP (not shown)." ], "offsets": [ [ 0, 89 ] ] } ]

[ { "id": "1.0alpha7.train.208.ent0_0", "type": "protein", "text": [ "gp160" ], "offsets": [ [ 16, 21 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q0H5Z4" } ] }, { "id": "1.0alpha7.train.208.ent1_0", "type": "chemical", "text": [ "ATP" ], "offsets": [ [ 73, 76 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5957" } ] }, { "id": "1.0alpha7.train.208.ent2_0", "type": "protein", "text": [ "calreticulin" ], "offsets": [ [ 40, 52 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "811" }, { "db_name": "hgnc", "db_id": "CALR" }, { "db_name": "uniprot", "db_id": "P27797" } ] } ]

[]

[ { "id": "1.0alpha7.train.208.coref0", "entity_ids": [ "1.0alpha7.train.208.ent0_0" ] }, { "id": "1.0alpha7.train.208.coref1", "entity_ids": [ "1.0alpha7.train.208.ent1_0" ] }, { "id": "1.0alpha7.train.208.coref2", "entity_ids": [ "1.0alpha7.train.208.ent2_0" ] } ]

[ { "id": "1.0alpha7.train.208.rel0s1.0alpha7.train.208.ent0_0.o1.0alpha7.train.208.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.208.ent0_0", "arg2_id": "1.0alpha7.train.208.ent2_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.209.sent", "type": "sentence", "text": [ "Because PIP2 was added in the form of micelles, the effects of actin and PIP2 on profilin binding to gephyrin cannot be compared in terms of affinities." ], "offsets": [ [ 0, 152 ] ] } ]

[ { "id": "1.0alpha7.train.209.ent0_0", "type": "protein", "text": [ "gephyrin" ], "offsets": [ [ 101, 109 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "10243" }, { "db_name": "hgnc", "db_id": "GPHN" }, { "db_name": "uniprot", "db_id": "Q9NQX3" } ] }, { "id": "1.0alpha7.train.209.ent1_0", "type": "protein-family", "text": [ "profilin" ], "offsets": [ [ 81, 89 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR005455" } ] }, { "id": "1.0alpha7.train.209.ent2_0", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 63, 68 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] }, { "id": "1.0alpha7.train.209.ent3_0", "type": "chemical", "text": [ "PIP2" ], "offsets": [ [ 8, 12 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5497157" } ] }, { "id": "1.0alpha7.train.209.ent4_1", "type": "chemical", "text": [ "PIP2" ], "offsets": [ [ 73, 77 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5497157" } ] } ]

[]

[ { "id": "1.0alpha7.train.209.coref0", "entity_ids": [ "1.0alpha7.train.209.ent0_0" ] }, { "id": "1.0alpha7.train.209.coref1", "entity_ids": [ "1.0alpha7.train.209.ent1_0" ] }, { "id": "1.0alpha7.train.209.coref2", "entity_ids": [ "1.0alpha7.train.209.ent2_0" ] }, { "id": "1.0alpha7.train.209.coref3", "entity_ids": [ "1.0alpha7.train.209.ent3_0", "1.0alpha7.train.209.ent4_1" ] } ]

[ { "id": "1.0alpha7.train.209.rel0s1.0alpha7.train.209.ent0_0.o1.0alpha7.train.209.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.209.ent0_0", "arg2_id": "1.0alpha7.train.209.ent1_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.210.sent", "type": "sentence", "text": [ "This situation is similar to that of pI cells, where overexpression of the GTP-bound form of Galphai, GalphaiQ205L, also influences the orientation of the spindle." ], "offsets": [ [ 0, 163 ] ] } ]

[ { "id": "1.0alpha7.train.210.ent0_0", "type": "chemical", "text": [ "GTP" ], "offsets": [ [ 75, 78 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "135398633" } ] }, { "id": "1.0alpha7.train.210.ent1_0", "type": "protein", "text": [ "GalphaiQ205L" ], "offsets": [ [ 102, 114 ] ], "normalized": [] }, { "id": "1.0alpha7.train.210.ent2_0", "type": "cell", "text": [ "pI" ], "offsets": [ [ 37, 39 ] ], "normalized": [] }, { "id": "1.0alpha7.train.210.ent3_0", "type": "protein", "text": [ "Galphai" ], "offsets": [ [ 93, 100 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P20353" } ] }, { "id": "1.0alpha7.train.210.ent4_0", "type": "protein", "text": [ "GTP-bound form of Galphai" ], "offsets": [ [ 75, 100 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.210.coref0", "entity_ids": [ "1.0alpha7.train.210.ent0_0" ] }, { "id": "1.0alpha7.train.210.coref1", "entity_ids": [ "1.0alpha7.train.210.ent1_0" ] }, { "id": "1.0alpha7.train.210.coref2", "entity_ids": [ "1.0alpha7.train.210.ent2_0" ] }, { "id": "1.0alpha7.train.210.coref3", "entity_ids": [ "1.0alpha7.train.210.ent3_0" ] }, { "id": "1.0alpha7.train.210.coref4", "entity_ids": [ "1.0alpha7.train.210.ent4_0" ] } ]

[ { "id": "1.0alpha7.train.210.rel0s1.0alpha7.train.210.ent0_0.o1.0alpha7.train.210.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.210.ent0_0", "arg2_id": "1.0alpha7.train.210.ent3_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.211.sent", "type": "sentence", "text": [ "Therefore, we hypothesized that co-stimulatory molecules that preferentially bind CD28 or CTLA-4 would have dramatically altered biological properties." ], "offsets": [ [ 0, 151 ] ] } ]

[ { "id": "1.0alpha7.train.211.ent0_0", "type": "protein", "text": [ "CD28" ], "offsets": [ [ 82, 86 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "940" }, { "db_name": "hgnc", "db_id": "CD28" }, { "db_name": "uniprot", "db_id": "P10747" } ] }, { "id": "1.0alpha7.train.211.ent1_0", "type": "protein", "text": [ "CTLA-4" ], "offsets": [ [ 90, 96 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1493" }, { "db_name": "hgnc", "db_id": "CTLA4" }, { "db_name": "uniprot", "db_id": "P16410" } ] } ]

[]

[ { "id": "1.0alpha7.train.211.coref0", "entity_ids": [ "1.0alpha7.train.211.ent0_0" ] }, { "id": "1.0alpha7.train.211.coref1", "entity_ids": [ "1.0alpha7.train.211.ent1_0" ] } ]

[]

[ { "id": "1.0alpha7.train.212.sent", "type": "sentence", "text": [ "Using electrophoretic mobility shift assays (EMSA), we found that Dfd binds to this fragment ( S3/240bpwt; Figure 5D)." ], "offsets": [ [ 0, 118 ] ] } ]

[ { "id": "1.0alpha7.train.212.ent0_0", "type": "experimental-construct", "text": [ "S3/240bpwt" ], "offsets": [ [ 95, 105 ] ], "normalized": [] }, { "id": "1.0alpha7.train.212.ent1_0", "type": "protein", "text": [ "Dfd" ], "offsets": [ [ 66, 69 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P07548" } ] }, { "id": "1.0alpha7.train.212.ent2_0", "type": "assay", "text": [ "EMSA" ], "offsets": [ [ 45, 49 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.212.coref0", "entity_ids": [ "1.0alpha7.train.212.ent0_0" ] }, { "id": "1.0alpha7.train.212.coref1", "entity_ids": [ "1.0alpha7.train.212.ent1_0" ] }, { "id": "1.0alpha7.train.212.coref2", "entity_ids": [ "1.0alpha7.train.212.ent2_0" ] } ]

[]

[ { "id": "1.0alpha7.train.213.sent", "type": "sentence", "text": [ "The INK family has a specificity for the early G1 kinases Cdk4 and Cdk6 complexed with D-type cyclins, while the CIP family is partial to Cdk2 bound to either cyclin A or E." ], "offsets": [ [ 0, 173 ] ] } ]

[ { "id": "1.0alpha7.train.213.ent0_0", "type": "protein-family", "text": [ "D-type cyclins" ], "offsets": [ [ 87, 101 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR015451" } ] }, { "id": "1.0alpha7.train.213.ent1_0", "type": "protein", "text": [ "E" ], "offsets": [ [ 171, 172 ] ], "normalized": [] }, { "id": "1.0alpha7.train.213.ent2_0", "type": "protein", "text": [ "cyclin A" ], "offsets": [ [ 159, 167 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8900" }, { "db_name": "hgnc", "db_id": "CCNA1" }, { "db_name": "uniprot", "db_id": "P78396" } ] }, { "id": "1.0alpha7.train.213.ent3_0", "type": "protein-family", "text": [ "INK family" ], "offsets": [ [ 4, 14 ] ], "normalized": [] }, { "id": "1.0alpha7.train.213.ent4_0", "type": "protein", "text": [ "Cdk2" ], "offsets": [ [ 138, 142 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1017" }, { "db_name": "hgnc", "db_id": "CDK2" }, { "db_name": "uniprot", "db_id": "P24941" } ] }, { "id": "1.0alpha7.train.213.ent5_0", "type": "protein", "text": [ "Cdk4" ], "offsets": [ [ 58, 62 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1019" }, { "db_name": "hgnc", "db_id": "CDK4" }, { "db_name": "uniprot", "db_id": "P11802" } ] }, { "id": "1.0alpha7.train.213.ent6_0", "type": "protein", "text": [ "Cdk6" ], "offsets": [ [ 67, 71 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1021" }, { "db_name": "hgnc", "db_id": "CDK6" }, { "db_name": "uniprot", "db_id": "Q00534" } ] }, { "id": "1.0alpha7.train.213.ent7_0", "type": "protein-family", "text": [ "CIP family" ], "offsets": [ [ 113, 123 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.213.coref0", "entity_ids": [ "1.0alpha7.train.213.ent0_0" ] }, { "id": "1.0alpha7.train.213.coref1", "entity_ids": [ "1.0alpha7.train.213.ent1_0" ] }, { "id": "1.0alpha7.train.213.coref2", "entity_ids": [ "1.0alpha7.train.213.ent2_0" ] }, { "id": "1.0alpha7.train.213.coref3", "entity_ids": [ "1.0alpha7.train.213.ent3_0" ] }, { "id": "1.0alpha7.train.213.coref4", "entity_ids": [ "1.0alpha7.train.213.ent4_0" ] }, { "id": "1.0alpha7.train.213.coref5", "entity_ids": [ "1.0alpha7.train.213.ent5_0" ] }, { "id": "1.0alpha7.train.213.coref6", "entity_ids": [ "1.0alpha7.train.213.ent6_0" ] }, { "id": "1.0alpha7.train.213.coref7", "entity_ids": [ "1.0alpha7.train.213.ent7_0" ] } ]

[ { "id": "1.0alpha7.train.213.rel0s1.0alpha7.train.213.ent0_0.o1.0alpha7.train.213.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.213.ent0_0", "arg2_id": "1.0alpha7.train.213.ent5_0", "normalized": [] }, { "id": "1.0alpha7.train.213.rel1s1.0alpha7.train.213.ent0_0.o1.0alpha7.train.213.ent6_0", "type": "bind", "arg1_id": "1.0alpha7.train.213.ent0_0", "arg2_id": "1.0alpha7.train.213.ent6_0", "normalized": [] }, { "id": "1.0alpha7.train.213.rel2s1.0alpha7.train.213.ent2_0.o1.0alpha7.train.213.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.213.ent2_0", "arg2_id": "1.0alpha7.train.213.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.213.rel3s1.0alpha7.train.213.ent1_0.o1.0alpha7.train.213.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.213.ent1_0", "arg2_id": "1.0alpha7.train.213.ent4_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.214.sent", "type": "sentence", "text": [ "These results suggest that most of the synergistic coactivation by CRP2 requires efficient binding of SRF to multiple SREs." ], "offsets": [ [ 0, 123 ] ] } ]

[ { "id": "1.0alpha7.train.214.ent0_0", "type": "DNA", "text": [ "SREs" ], "offsets": [ [ 118, 122 ] ], "normalized": [] }, { "id": "1.0alpha7.train.214.ent1_0", "type": "protein", "text": [ "SRF" ], "offsets": [ [ 102, 105 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6722" }, { "db_name": "hgnc", "db_id": "SRF" }, { "db_name": "uniprot", "db_id": "P11831" } ] }, { "id": "1.0alpha7.train.214.ent2_0", "type": "protein", "text": [ "CRP2" ], "offsets": [ [ 67, 71 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1466" }, { "db_name": "hgnc", "db_id": "CSRP2" }, { "db_name": "uniprot", "db_id": "Q16527" } ] } ]

[]

[ { "id": "1.0alpha7.train.214.coref0", "entity_ids": [ "1.0alpha7.train.214.ent0_0" ] }, { "id": "1.0alpha7.train.214.coref1", "entity_ids": [ "1.0alpha7.train.214.ent1_0" ] }, { "id": "1.0alpha7.train.214.coref2", "entity_ids": [ "1.0alpha7.train.214.ent2_0" ] } ]

[ { "id": "1.0alpha7.train.214.rel0s1.0alpha7.train.214.ent0_0.o1.0alpha7.train.214.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.214.ent0_0", "arg2_id": "1.0alpha7.train.214.ent1_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.215.sent", "type": "sentence", "text": [ "These membrane lipids bind to the actin-binding domains of AC ( Yonezawa et al 1991a, Kusano et al 1999) and are capable of inhibiting AC binding to actin in vitro." ], "offsets": [ [ 0, 164 ] ] } ]

[ { "id": "1.0alpha7.train.215.ent0_0", "type": "protein-family", "text": [ "AC" ], "offsets": [ [ 59, 61 ] ], "normalized": [] }, { "id": "1.0alpha7.train.215.ent1_1", "type": "protein-family", "text": [ "AC" ], "offsets": [ [ 135, 137 ] ], "normalized": [] }, { "id": "1.0alpha7.train.215.ent2_0", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 34, 39 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] }, { "id": "1.0alpha7.train.215.ent3_1", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 149, 154 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] }, { "id": "1.0alpha7.train.215.ent4_0", "type": "chemical", "text": [ "lipids" ], "offsets": [ [ 15, 21 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.215.coref0", "entity_ids": [ "1.0alpha7.train.215.ent0_0", "1.0alpha7.train.215.ent1_1" ] }, { "id": "1.0alpha7.train.215.coref1", "entity_ids": [ "1.0alpha7.train.215.ent2_0", "1.0alpha7.train.215.ent3_1" ] }, { "id": "1.0alpha7.train.215.coref2", "entity_ids": [ "1.0alpha7.train.215.ent4_0" ] } ]

[ { "id": "1.0alpha7.train.215.rel0s1.0alpha7.train.215.ent0_0.o1.0alpha7.train.215.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.215.ent0_0", "arg2_id": "1.0alpha7.train.215.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.215.rel0s1.0alpha7.train.215.ent0_0.o1.0alpha7.train.215.ent3_1", "type": "bind", "arg1_id": "1.0alpha7.train.215.ent0_0", "arg2_id": "1.0alpha7.train.215.ent3_1", "normalized": [] }, { "id": "1.0alpha7.train.215.rel0s1.0alpha7.train.215.ent1_1.o1.0alpha7.train.215.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.215.ent1_1", "arg2_id": "1.0alpha7.train.215.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.215.rel0s1.0alpha7.train.215.ent1_1.o1.0alpha7.train.215.ent3_1", "type": "bind", "arg1_id": "1.0alpha7.train.215.ent1_1", "arg2_id": "1.0alpha7.train.215.ent3_1", "normalized": [] }, { "id": "1.0alpha7.train.215.rel1s1.0alpha7.train.215.ent0_0.o1.0alpha7.train.215.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.215.ent0_0", "arg2_id": "1.0alpha7.train.215.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.215.rel1s1.0alpha7.train.215.ent1_1.o1.0alpha7.train.215.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.215.ent1_1", "arg2_id": "1.0alpha7.train.215.ent4_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.216.sent", "type": "sentence", "text": [ "In addition, Redlitz et al. (10) showed that activated pro-plasma carboxypeptidase B and plasma carboxypeptidase N diminish the binding of plasminogen to U937 cells and that fibrinolysis occurs more rapidly in pro-plasma carboxypeptidase B (TAFI)-deficient compared with normal plasma." ], "offsets": [ [ 0, 285 ] ] } ]

[ { "id": "1.0alpha7.train.216.ent0_0", "type": "cell", "text": [ "U937" ], "offsets": [ [ 154, 158 ] ], "normalized": [] }, { "id": "1.0alpha7.train.216.ent1_0", "type": "protein", "text": [ "carboxypeptidase B" ], "offsets": [ [ 66, 84 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1360" }, { "db_name": "hgnc", "db_id": "CPB1" }, { "db_name": "uniprot", "db_id": "P15086" } ] }, { "id": "1.0alpha7.train.216.ent2_1", "type": "protein", "text": [ "carboxypeptidase B" ], "offsets": [ [ 221, 239 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1360" }, { "db_name": "hgnc", "db_id": "CPB1" }, { "db_name": "uniprot", "db_id": "P15086" } ] }, { "id": "1.0alpha7.train.216.ent3_0", "type": "protein", "text": [ "plasminogen" ], "offsets": [ [ 139, 150 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5340" }, { "db_name": "hgnc", "db_id": "PLG" }, { "db_name": "uniprot", "db_id": "P00747" } ] }, { "id": "1.0alpha7.train.216.ent4_0", "type": "protein", "text": [ "carboxypeptidase N" ], "offsets": [ [ 96, 114 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1369" }, { "db_name": "hgnc", "db_id": "CPN1" }, { "db_name": "uniprot", "db_id": "P15169" } ] }, { "id": "1.0alpha7.train.216.ent5_0", "type": "protein", "text": [ "TAFI" ], "offsets": [ [ 241, 245 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1361" }, { "db_name": "hgnc", "db_id": "CPB2" }, { "db_name": "uniprot", "db_id": "Q96IY4" } ] } ]

[]

[ { "id": "1.0alpha7.train.216.coref0", "entity_ids": [ "1.0alpha7.train.216.ent0_0" ] }, { "id": "1.0alpha7.train.216.coref1", "entity_ids": [ "1.0alpha7.train.216.ent1_0", "1.0alpha7.train.216.ent2_1" ] }, { "id": "1.0alpha7.train.216.coref2", "entity_ids": [ "1.0alpha7.train.216.ent3_0" ] }, { "id": "1.0alpha7.train.216.coref3", "entity_ids": [ "1.0alpha7.train.216.ent4_0" ] }, { "id": "1.0alpha7.train.216.coref4", "entity_ids": [ "1.0alpha7.train.216.ent5_0" ] } ]

[]

[ { "id": "1.0alpha7.train.217.sent", "type": "sentence", "text": [ "Tyrosine Phosphorylation of p190 Correlates with Enhanced p120 GAP Binding in Vivo; Because p120 protein preferentially binds phosphorylated p190 in vitro, we compared the levels of native p120•p190 complex formation in normal 3Y1 rat fibroblasts and v-Src-transformed 3Y1 cells (SR3Y1)." ], "offsets": [ [ 0, 287 ] ] } ]

[ { "id": "1.0alpha7.train.217.ent0_0", "type": "cell", "text": [ "SR3Y1" ], "offsets": [ [ 280, 285 ] ], "normalized": [] }, { "id": "1.0alpha7.train.217.ent1_0", "type": "cell", "text": [ "v-Src-transformed 3Y1 cells" ], "offsets": [ [ 251, 278 ] ], "normalized": [] }, { "id": "1.0alpha7.train.217.ent2_0", "type": "protein", "text": [ "p190" ], "offsets": [ [ 28, 32 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2909" }, { "db_name": "hgnc", "db_id": "ARHGAP35" }, { "db_name": "uniprot", "db_id": "Q9NRY4" } ] }, { "id": "1.0alpha7.train.217.ent3_1", "type": "protein", "text": [ "p190" ], "offsets": [ [ 141, 145 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2909" }, { "db_name": "hgnc", "db_id": "ARHGAP35" }, { "db_name": "uniprot", "db_id": "Q9NRY4" } ] }, { "id": "1.0alpha7.train.217.ent4_2", "type": "protein", "text": [ "p190" ], "offsets": [ [ 194, 198 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2909" }, { "db_name": "hgnc", "db_id": "ARHGAP35" }, { "db_name": "uniprot", "db_id": "Q9NRY4" } ] }, { "id": "1.0alpha7.train.217.ent5_0", "type": "cell", "text": [ "3Y1 rat fibroblasts" ], "offsets": [ [ 227, 246 ] ], "normalized": [] }, { "id": "1.0alpha7.train.217.ent6_0", "type": "protein", "text": [ "p120 GAP" ], "offsets": [ [ 58, 66 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5921" }, { "db_name": "hgnc", "db_id": "RASA1" }, { "db_name": "uniprot", "db_id": "P20936" } ] } ]

[]

[ { "id": "1.0alpha7.train.217.coref0", "entity_ids": [ "1.0alpha7.train.217.ent0_0", "1.0alpha7.train.217.ent1_0" ] }, { "id": "1.0alpha7.train.217.coref1", "entity_ids": [ "1.0alpha7.train.217.ent2_0", "1.0alpha7.train.217.ent3_1", "1.0alpha7.train.217.ent4_2" ] }, { "id": "1.0alpha7.train.217.coref2", "entity_ids": [ "1.0alpha7.train.217.ent5_0" ] }, { "id": "1.0alpha7.train.217.coref3", "entity_ids": [ "1.0alpha7.train.217.ent6_0" ] } ]

[ { "id": "1.0alpha7.train.217.rel0s1.0alpha7.train.217.ent2_0.o1.0alpha7.train.217.ent6_0", "type": "bind", "arg1_id": "1.0alpha7.train.217.ent2_0", "arg2_id": "1.0alpha7.train.217.ent6_0", "normalized": [] }, { "id": "1.0alpha7.train.217.rel0s1.0alpha7.train.217.ent3_1.o1.0alpha7.train.217.ent6_0", "type": "bind", "arg1_id": "1.0alpha7.train.217.ent3_1", "arg2_id": "1.0alpha7.train.217.ent6_0", "normalized": [] }, { "id": "1.0alpha7.train.217.rel0s1.0alpha7.train.217.ent4_2.o1.0alpha7.train.217.ent6_0", "type": "bind", "arg1_id": "1.0alpha7.train.217.ent4_2", "arg2_id": "1.0alpha7.train.217.ent6_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.218.sent", "type": "sentence", "text": [ "Furthermore, we determined that this regionalized editing of the collagen substrate was orchestrated by the stimulated expression of collagenase-1, which was bound to the SMC plasma membrane." ], "offsets": [ [ 0, 191 ] ] } ]

[ { "id": "1.0alpha7.train.218.ent0_0", "type": "protein-family", "text": [ "collagen" ], "offsets": [ [ 65, 73 ] ], "normalized": [] }, { "id": "1.0alpha7.train.218.ent1_0", "type": "cell", "text": [ "SMC" ], "offsets": [ [ 171, 174 ] ], "normalized": [] }, { "id": "1.0alpha7.train.218.ent2_0", "type": "protein", "text": [ "collagenase-1" ], "offsets": [ [ 133, 146 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4312" }, { "db_name": "hgnc", "db_id": "MMP1" }, { "db_name": "uniprot", "db_id": "P03956" } ] } ]

[]

[ { "id": "1.0alpha7.train.218.coref0", "entity_ids": [ "1.0alpha7.train.218.ent0_0" ] }, { "id": "1.0alpha7.train.218.coref1", "entity_ids": [ "1.0alpha7.train.218.ent1_0" ] }, { "id": "1.0alpha7.train.218.coref2", "entity_ids": [ "1.0alpha7.train.218.ent2_0" ] } ]

[]

[ { "id": "1.0alpha7.train.219.sent", "type": "sentence", "text": [ "After transfection of vectors expressing MUC1 and GSK3beta, 293 cells were subjected to immunoprecipitation with anti-MUC1 and the precipitates were analyzed for binding of MUC1 to beta-catenin." ], "offsets": [ [ 0, 194 ] ] } ]

[ { "id": "1.0alpha7.train.219.ent0_0", "type": "protein", "text": [ "beta-catenin" ], "offsets": [ [ 181, 193 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1499" }, { "db_name": "hgnc", "db_id": "CTNNB1" }, { "db_name": "uniprot", "db_id": "P35222" } ] }, { "id": "1.0alpha7.train.219.ent1_0", "type": "protein", "text": [ "MUC1" ], "offsets": [ [ 41, 45 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4582" }, { "db_name": "hgnc", "db_id": "MUC1" } ] }, { "id": "1.0alpha7.train.219.ent2_1", "type": "protein", "text": [ "MUC1" ], "offsets": [ [ 118, 122 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4582" }, { "db_name": "hgnc", "db_id": "MUC1" } ] }, { "id": "1.0alpha7.train.219.ent3_2", "type": "protein", "text": [ "MUC1" ], "offsets": [ [ 173, 177 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4582" }, { "db_name": "hgnc", "db_id": "MUC1" } ] }, { "id": "1.0alpha7.train.219.ent4_0", "type": "reagent", "text": [ "anti-MUC1" ], "offsets": [ [ 113, 122 ] ], "normalized": [] }, { "id": "1.0alpha7.train.219.ent5_0", "type": "protein", "text": [ "GSK3beta" ], "offsets": [ [ 50, 58 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2932" }, { "db_name": "hgnc", "db_id": "GSK3B" }, { "db_name": "uniprot", "db_id": "P49841" } ] } ]

[]

[ { "id": "1.0alpha7.train.219.coref0", "entity_ids": [ "1.0alpha7.train.219.ent0_0" ] }, { "id": "1.0alpha7.train.219.coref1", "entity_ids": [ "1.0alpha7.train.219.ent1_0", "1.0alpha7.train.219.ent2_1", "1.0alpha7.train.219.ent3_2" ] }, { "id": "1.0alpha7.train.219.coref2", "entity_ids": [ "1.0alpha7.train.219.ent4_0" ] }, { "id": "1.0alpha7.train.219.coref3", "entity_ids": [ "1.0alpha7.train.219.ent5_0" ] } ]

[]

[ { "id": "1.0alpha7.train.220.sent", "type": "sentence", "text": [ "This orientation shows the actin-binding surface of profilin [14,15] , which is predominately composed of the C-terminal helix (H3) and the bottom three strands ( 4, 5 and 6) of the central sheet." ], "offsets": [ [ 0, 196 ] ] } ]

[ { "id": "1.0alpha7.train.220.ent0_0", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 27, 32 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] }, { "id": "1.0alpha7.train.220.ent1_0", "type": "protein-family", "text": [ "profilin" ], "offsets": [ [ 52, 60 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR005455" } ] } ]

[]

[ { "id": "1.0alpha7.train.220.coref0", "entity_ids": [ "1.0alpha7.train.220.ent0_0" ] }, { "id": "1.0alpha7.train.220.coref1", "entity_ids": [ "1.0alpha7.train.220.ent1_0" ] } ]

[ { "id": "1.0alpha7.train.220.rel0s1.0alpha7.train.220.ent0_0.o1.0alpha7.train.220.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.220.ent0_0", "arg2_id": "1.0alpha7.train.220.ent1_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.221.sent", "type": "sentence", "text": [ "Binding of Cdc20 and Cdh1 to the APC is differentially regulated." ], "offsets": [ [ 0, 65 ] ] } ]

[ { "id": "1.0alpha7.train.221.ent0_0", "type": "protein", "text": [ "Cdh1" ], "offsets": [ [ 21, 25 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "999" }, { "db_name": "hgnc", "db_id": "CDH1" }, { "db_name": "uniprot", "db_id": "P12830" } ] }, { "id": "1.0alpha7.train.221.ent1_0", "type": "protein", "text": [ "APC" ], "offsets": [ [ 33, 36 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "324" }, { "db_name": "hgnc", "db_id": "APC" } ] }, { "id": "1.0alpha7.train.221.ent2_0", "type": "protein", "text": [ "Cdc20" ], "offsets": [ [ 11, 16 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "991" }, { "db_name": "hgnc", "db_id": "CDC20" }, { "db_name": "uniprot", "db_id": "Q12834" } ] } ]

[]

[ { "id": "1.0alpha7.train.221.coref0", "entity_ids": [ "1.0alpha7.train.221.ent0_0" ] }, { "id": "1.0alpha7.train.221.coref1", "entity_ids": [ "1.0alpha7.train.221.ent1_0" ] }, { "id": "1.0alpha7.train.221.coref2", "entity_ids": [ "1.0alpha7.train.221.ent2_0" ] } ]

[ { "id": "1.0alpha7.train.221.rel0s1.0alpha7.train.221.ent1_0.o1.0alpha7.train.221.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.221.ent1_0", "arg2_id": "1.0alpha7.train.221.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.221.rel1s1.0alpha7.train.221.ent0_0.o1.0alpha7.train.221.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.221.ent0_0", "arg2_id": "1.0alpha7.train.221.ent1_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.222.sent", "type": "sentence", "text": [ "With the goal of learning more about the mechanisms responsible for insulating activity, we have identified and characterized SBP ( scs binding protein), a protein component of the scs nucleoprotein complex." ], "offsets": [ [ 0, 207 ] ] } ]

[ { "id": "1.0alpha7.train.222.ent0_0", "type": "protein", "text": [ "SBP" ], "offsets": [ [ 126, 129 ] ], "normalized": [] }, { "id": "1.0alpha7.train.222.ent1_0", "type": "protein", "text": [ "scs binding protein" ], "offsets": [ [ 132, 151 ] ], "normalized": [] }, { "id": "1.0alpha7.train.222.ent2_0", "type": "protein-complex", "text": [ "scs" ], "offsets": [ [ 132, 135 ] ], "normalized": [] }, { "id": "1.0alpha7.train.222.ent3_1", "type": "protein-complex", "text": [ "scs" ], "offsets": [ [ 181, 184 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.222.coref0", "entity_ids": [ "1.0alpha7.train.222.ent0_0", "1.0alpha7.train.222.ent1_0" ] }, { "id": "1.0alpha7.train.222.coref1", "entity_ids": [ "1.0alpha7.train.222.ent2_0", "1.0alpha7.train.222.ent3_1" ] } ]

[ { "id": "1.0alpha7.train.222.rel0s1.0alpha7.train.222.ent0_0.o1.0alpha7.train.222.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.222.ent0_0", "arg2_id": "1.0alpha7.train.222.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.222.rel0s1.0alpha7.train.222.ent0_0.o1.0alpha7.train.222.ent3_1", "type": "bind", "arg1_id": "1.0alpha7.train.222.ent0_0", "arg2_id": "1.0alpha7.train.222.ent3_1", "normalized": [] }, { "id": "1.0alpha7.train.222.rel0s1.0alpha7.train.222.ent1_0.o1.0alpha7.train.222.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.222.ent1_0", "arg2_id": "1.0alpha7.train.222.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.222.rel0s1.0alpha7.train.222.ent1_0.o1.0alpha7.train.222.ent3_1", "type": "bind", "arg1_id": "1.0alpha7.train.222.ent1_0", "arg2_id": "1.0alpha7.train.222.ent3_1", "normalized": [] } ]

[ { "id": "1.0alpha7.train.223.sent", "type": "sentence", "text": [ "Thus, the binding of Porc with Wg appears to be necessary for the stimulation of the N-glycosylation of Wg." ], "offsets": [ [ 0, 107 ] ] } ]

[ { "id": "1.0alpha7.train.223.ent0_0", "type": "protein", "text": [ "Wg" ], "offsets": [ [ 31, 33 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P09615" } ] }, { "id": "1.0alpha7.train.223.ent1_1", "type": "protein", "text": [ "Wg" ], "offsets": [ [ 104, 106 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P09615" } ] }, { "id": "1.0alpha7.train.223.ent2_0", "type": "protein", "text": [ "Porc" ], "offsets": [ [ 21, 25 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3145" }, { "db_name": "hgnc", "db_id": "HMBS" }, { "db_name": "uniprot", "db_id": "P08397" } ] } ]

[]

[ { "id": "1.0alpha7.train.223.coref0", "entity_ids": [ "1.0alpha7.train.223.ent0_0", "1.0alpha7.train.223.ent1_1" ] }, { "id": "1.0alpha7.train.223.coref1", "entity_ids": [ "1.0alpha7.train.223.ent2_0" ] } ]

[ { "id": "1.0alpha7.train.223.rel0s1.0alpha7.train.223.ent0_0.o1.0alpha7.train.223.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.223.ent0_0", "arg2_id": "1.0alpha7.train.223.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.223.rel0s1.0alpha7.train.223.ent1_1.o1.0alpha7.train.223.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.223.ent1_1", "arg2_id": "1.0alpha7.train.223.ent2_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.224.sent", "type": "sentence", "text": [ "Pals1 (or Sdt) binds to the Crb-PBM motif (CrbPBM) via its single PDZ domain." ], "offsets": [ [ 0, 77 ] ] } ]

[ { "id": "1.0alpha7.train.224.ent0_0", "type": "protein", "text": [ "Sdt" ], "offsets": [ [ 10, 13 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "64398" }, { "db_name": "hgnc", "db_id": "MPP5" }, { "db_name": "uniprot", "db_id": "Q8N3R9" } ] }, { "id": "1.0alpha7.train.224.ent1_0", "type": "protein", "text": [ "Pals1" ], "offsets": [ [ 0, 5 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "64398" }, { "db_name": "hgnc", "db_id": "MPP5" }, { "db_name": "uniprot", "db_id": "Q8N3R9" } ] }, { "id": "1.0alpha7.train.224.ent2_0", "type": "protein-motif", "text": [ "CrbPBM" ], "offsets": [ [ 43, 49 ] ], "normalized": [] }, { "id": "1.0alpha7.train.224.ent3_0", "type": "protein-motif", "text": [ "Crb-PBM motif" ], "offsets": [ [ 28, 41 ] ], "normalized": [] }, { "id": "1.0alpha7.train.224.ent4_0", "type": "protein-domain", "text": [ "PDZ" ], "offsets": [ [ 66, 69 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR001478" } ] } ]

[]

[ { "id": "1.0alpha7.train.224.coref0", "entity_ids": [ "1.0alpha7.train.224.ent0_0", "1.0alpha7.train.224.ent1_0" ] }, { "id": "1.0alpha7.train.224.coref1", "entity_ids": [ "1.0alpha7.train.224.ent2_0", "1.0alpha7.train.224.ent3_0" ] }, { "id": "1.0alpha7.train.224.coref2", "entity_ids": [ "1.0alpha7.train.224.ent4_0" ] } ]

[]

[ { "id": "1.0alpha7.train.225.sent", "type": "sentence", "text": [ "Under these conditions, Hbp binds heme in a 1:1 molar ratio (unpublished data)." ], "offsets": [ [ 0, 79 ] ] } ]

[ { "id": "1.0alpha7.train.225.ent0_0", "type": "protein", "text": [ "Hbp" ], "offsets": [ [ 24, 27 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "566" }, { "db_name": "hgnc", "db_id": "AZU1" }, { "db_name": "uniprot", "db_id": "P20160" } ] }, { "id": "1.0alpha7.train.225.ent1_0", "type": "chemical", "text": [ "heme" ], "offsets": [ [ 34, 38 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "26945" } ] } ]

[]

[ { "id": "1.0alpha7.train.225.coref0", "entity_ids": [ "1.0alpha7.train.225.ent0_0" ] }, { "id": "1.0alpha7.train.225.coref1", "entity_ids": [ "1.0alpha7.train.225.ent1_0" ] } ]

[ { "id": "1.0alpha7.train.225.rel0s1.0alpha7.train.225.ent0_0.o1.0alpha7.train.225.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.225.ent0_0", "arg2_id": "1.0alpha7.train.225.ent1_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.226.sent", "type": "sentence", "text": [ "Both Axin and Axil bind not only to GSK-3beta but also to beta-catenin and APC ( 14-20) and promote GSK-3beta-dependent phosphorylation of beta-catenin and APC ( 14, 15, 19, 21, 22)." ], "offsets": [ [ 0, 182 ] ] } ]

[ { "id": "1.0alpha7.train.226.ent0_0", "type": "protein", "text": [ "Axil" ], "offsets": [ [ 14, 18 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8313" }, { "db_name": "hgnc", "db_id": "AXIN2" }, { "db_name": "uniprot", "db_id": "A0A087WXP8" } ] }, { "id": "1.0alpha7.train.226.ent1_0", "type": "protein", "text": [ "beta-catenin" ], "offsets": [ [ 58, 70 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1499" }, { "db_name": "hgnc", "db_id": "CTNNB1" }, { "db_name": "uniprot", "db_id": "P35222" } ] }, { "id": "1.0alpha7.train.226.ent2_1", "type": "protein", "text": [ "beta-catenin" ], "offsets": [ [ 139, 151 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1499" }, { "db_name": "hgnc", "db_id": "CTNNB1" }, { "db_name": "uniprot", "db_id": "P35222" } ] }, { "id": "1.0alpha7.train.226.ent3_0", "type": "protein", "text": [ "Axin" ], "offsets": [ [ 5, 9 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8312" }, { "db_name": "hgnc", "db_id": "AXIN1" }, { "db_name": "uniprot", "db_id": "O15169" } ] }, { "id": "1.0alpha7.train.226.ent4_0", "type": "protein", "text": [ "GSK-3beta" ], "offsets": [ [ 36, 45 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2932" }, { "db_name": "hgnc", "db_id": "GSK3B" }, { "db_name": "uniprot", "db_id": "P49841" } ] }, { "id": "1.0alpha7.train.226.ent5_1", "type": "protein", "text": [ "GSK-3beta" ], "offsets": [ [ 100, 109 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2932" }, { "db_name": "hgnc", "db_id": "GSK3B" }, { "db_name": "uniprot", "db_id": "P49841" } ] }, { "id": "1.0alpha7.train.226.ent6_0", "type": "protein", "text": [ "APC" ], "offsets": [ [ 75, 78 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "324" }, { "db_name": "hgnc", "db_id": "APC" } ] }, { "id": "1.0alpha7.train.226.ent7_1", "type": "protein", "text": [ "APC" ], "offsets": [ [ 156, 159 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "324" }, { "db_name": "hgnc", "db_id": "APC" } ] } ]

[]

[ { "id": "1.0alpha7.train.226.coref0", "entity_ids": [ "1.0alpha7.train.226.ent0_0" ] }, { "id": "1.0alpha7.train.226.coref1", "entity_ids": [ "1.0alpha7.train.226.ent1_0", "1.0alpha7.train.226.ent2_1" ] }, { "id": "1.0alpha7.train.226.coref2", "entity_ids": [ "1.0alpha7.train.226.ent3_0" ] }, { "id": "1.0alpha7.train.226.coref3", "entity_ids": [ "1.0alpha7.train.226.ent4_0", "1.0alpha7.train.226.ent5_1" ] }, { "id": "1.0alpha7.train.226.coref4", "entity_ids": [ "1.0alpha7.train.226.ent6_0", "1.0alpha7.train.226.ent7_1" ] } ]

[ { "id": "1.0alpha7.train.226.rel0s1.0alpha7.train.226.ent3_0.o1.0alpha7.train.226.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.226.ent3_0", "arg2_id": "1.0alpha7.train.226.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.226.rel0s1.0alpha7.train.226.ent3_0.o1.0alpha7.train.226.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.226.ent3_0", "arg2_id": "1.0alpha7.train.226.ent5_1", "normalized": [] }, { "id": "1.0alpha7.train.226.rel1s1.0alpha7.train.226.ent1_0.o1.0alpha7.train.226.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.226.ent1_0", "arg2_id": "1.0alpha7.train.226.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.226.rel1s1.0alpha7.train.226.ent2_1.o1.0alpha7.train.226.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.226.ent2_1", "arg2_id": "1.0alpha7.train.226.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.226.rel2s1.0alpha7.train.226.ent3_0.o1.0alpha7.train.226.ent6_0", "type": "bind", "arg1_id": "1.0alpha7.train.226.ent3_0", "arg2_id": "1.0alpha7.train.226.ent6_0", "normalized": [] }, { "id": "1.0alpha7.train.226.rel2s1.0alpha7.train.226.ent3_0.o1.0alpha7.train.226.ent7_1", "type": "bind", "arg1_id": "1.0alpha7.train.226.ent3_0", "arg2_id": "1.0alpha7.train.226.ent7_1", "normalized": [] }, { "id": "1.0alpha7.train.226.rel3s1.0alpha7.train.226.ent0_0.o1.0alpha7.train.226.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.226.ent0_0", "arg2_id": "1.0alpha7.train.226.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.226.rel3s1.0alpha7.train.226.ent0_0.o1.0alpha7.train.226.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.226.ent0_0", "arg2_id": "1.0alpha7.train.226.ent5_1", "normalized": [] }, { "id": "1.0alpha7.train.226.rel4s1.0alpha7.train.226.ent0_0.o1.0alpha7.train.226.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.226.ent0_0", "arg2_id": "1.0alpha7.train.226.ent1_0", "normalized": [] }, { "id": "1.0alpha7.train.226.rel4s1.0alpha7.train.226.ent0_0.o1.0alpha7.train.226.ent2_1", "type": "bind", "arg1_id": "1.0alpha7.train.226.ent0_0", "arg2_id": "1.0alpha7.train.226.ent2_1", "normalized": [] }, { "id": "1.0alpha7.train.226.rel5s1.0alpha7.train.226.ent0_0.o1.0alpha7.train.226.ent6_0", "type": "bind", "arg1_id": "1.0alpha7.train.226.ent0_0", "arg2_id": "1.0alpha7.train.226.ent6_0", "normalized": [] }, { "id": "1.0alpha7.train.226.rel5s1.0alpha7.train.226.ent0_0.o1.0alpha7.train.226.ent7_1", "type": "bind", "arg1_id": "1.0alpha7.train.226.ent0_0", "arg2_id": "1.0alpha7.train.226.ent7_1", "normalized": [] } ]

[ { "id": "1.0alpha7.train.227.sent", "type": "sentence", "text": [ "Even though transportin can bind an M9 signal and the BIB domain simultaneously, it appears unlikely that transportin normally would import the two substrates at the same time: import of the trimeric M9-transportin-BIB complex is apparently much less efficient than import of, for example, an M9-transportin complex (not shown)." ], "offsets": [ [ 0, 328 ] ] } ]

[ { "id": "1.0alpha7.train.227.ent0_0", "type": "protein", "text": [ "transportin" ], "offsets": [ [ 12, 23 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3842" }, { "db_name": "hgnc", "db_id": "TNPO1" }, { "db_name": "uniprot", "db_id": "Q92973" } ] }, { "id": "1.0alpha7.train.227.ent1_1", "type": "protein", "text": [ "transportin" ], "offsets": [ [ 106, 117 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3842" }, { "db_name": "hgnc", "db_id": "TNPO1" }, { "db_name": "uniprot", "db_id": "Q92973" } ] }, { "id": "1.0alpha7.train.227.ent2_2", "type": "protein", "text": [ "transportin" ], "offsets": [ [ 203, 214 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3842" }, { "db_name": "hgnc", "db_id": "TNPO1" }, { "db_name": "uniprot", "db_id": "Q92973" } ] }, { "id": "1.0alpha7.train.227.ent3_3", "type": "protein", "text": [ "transportin" ], "offsets": [ [ 296, 307 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3842" }, { "db_name": "hgnc", "db_id": "TNPO1" }, { "db_name": "uniprot", "db_id": "Q92973" } ] }, { "id": "1.0alpha7.train.227.ent4_0", "type": "protein-motif", "text": [ "M9 signal" ], "offsets": [ [ 36, 45 ] ], "normalized": [] }, { "id": "1.0alpha7.train.227.ent5_0", "type": "protein-complex", "text": [ "M9-transportin-BIB" ], "offsets": [ [ 200, 218 ] ], "normalized": [] }, { "id": "1.0alpha7.train.227.ent6_0", "type": "protein-domain", "text": [ "BIB domain" ], "offsets": [ [ 54, 64 ] ], "normalized": [] }, { "id": "1.0alpha7.train.227.ent7_0", "type": "protein-complex", "text": [ "M9-transportin" ], "offsets": [ [ 200, 214 ] ], "normalized": [] }, { "id": "1.0alpha7.train.227.ent8_1", "type": "protein-complex", "text": [ "M9-transportin" ], "offsets": [ [ 293, 307 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.227.coref0", "entity_ids": [ "1.0alpha7.train.227.ent0_0", "1.0alpha7.train.227.ent1_1", "1.0alpha7.train.227.ent2_2", "1.0alpha7.train.227.ent3_3" ] }, { "id": "1.0alpha7.train.227.coref1", "entity_ids": [ "1.0alpha7.train.227.ent4_0" ] }, { "id": "1.0alpha7.train.227.coref2", "entity_ids": [ "1.0alpha7.train.227.ent5_0" ] }, { "id": "1.0alpha7.train.227.coref3", "entity_ids": [ "1.0alpha7.train.227.ent6_0" ] }, { "id": "1.0alpha7.train.227.coref4", "entity_ids": [ "1.0alpha7.train.227.ent7_0", "1.0alpha7.train.227.ent8_1" ] } ]

[ { "id": "1.0alpha7.train.227.rel0s1.0alpha7.train.227.ent0_0.o1.0alpha7.train.227.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.227.ent0_0", "arg2_id": "1.0alpha7.train.227.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.227.rel0s1.0alpha7.train.227.ent1_1.o1.0alpha7.train.227.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.227.ent1_1", "arg2_id": "1.0alpha7.train.227.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.227.rel0s1.0alpha7.train.227.ent2_2.o1.0alpha7.train.227.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.227.ent2_2", "arg2_id": "1.0alpha7.train.227.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.227.rel0s1.0alpha7.train.227.ent3_3.o1.0alpha7.train.227.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.227.ent3_3", "arg2_id": "1.0alpha7.train.227.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.227.rel1s1.0alpha7.train.227.ent0_0.o1.0alpha7.train.227.ent6_0", "type": "bind", "arg1_id": "1.0alpha7.train.227.ent0_0", "arg2_id": "1.0alpha7.train.227.ent6_0", "normalized": [] }, { "id": "1.0alpha7.train.227.rel1s1.0alpha7.train.227.ent1_1.o1.0alpha7.train.227.ent6_0", "type": "bind", "arg1_id": "1.0alpha7.train.227.ent1_1", "arg2_id": "1.0alpha7.train.227.ent6_0", "normalized": [] }, { "id": "1.0alpha7.train.227.rel1s1.0alpha7.train.227.ent2_2.o1.0alpha7.train.227.ent6_0", "type": "bind", "arg1_id": "1.0alpha7.train.227.ent2_2", "arg2_id": "1.0alpha7.train.227.ent6_0", "normalized": [] }, { "id": "1.0alpha7.train.227.rel1s1.0alpha7.train.227.ent3_3.o1.0alpha7.train.227.ent6_0", "type": "bind", "arg1_id": "1.0alpha7.train.227.ent3_3", "arg2_id": "1.0alpha7.train.227.ent6_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.228.sent", "type": "sentence", "text": [ "In vitro, HUA1 binds three tested AG RNA fragments from the second intron, one including the 5 splice site and the other two including the putative polyadenylation sites for the large AG RNAs." ], "offsets": [ [ 0, 192 ] ] } ]

[ { "id": "1.0alpha7.train.228.ent0_0", "type": "RNA", "text": [ "AG RNA" ], "offsets": [ [ 34, 40 ] ], "normalized": [] }, { "id": "1.0alpha7.train.228.ent1_0", "type": "protein", "text": [ "HUA1" ], "offsets": [ [ 10, 14 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q941Q3" } ] } ]

[]

[ { "id": "1.0alpha7.train.228.coref0", "entity_ids": [ "1.0alpha7.train.228.ent0_0" ] }, { "id": "1.0alpha7.train.228.coref1", "entity_ids": [ "1.0alpha7.train.228.ent1_0" ] } ]

[ { "id": "1.0alpha7.train.228.rel0s1.0alpha7.train.228.ent0_0.o1.0alpha7.train.228.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.228.ent0_0", "arg2_id": "1.0alpha7.train.228.ent1_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.229.sent", "type": "sentence", "text": [ "Nature, 377, 246-248 [Medline] orlich, D. , Henklein, P. , Laskey, R.A. and Hartmann, E. (1996a) A 41 amino acid motif in importin alpha confers binding to importin beta and hence transit into the nucleus." ], "offsets": [ [ 0, 205 ] ] } ]

[ { "id": "1.0alpha7.train.229.ent0_0", "type": "protein-family", "text": [ "importin alpha" ], "offsets": [ [ 122, 136 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR040122" } ] }, { "id": "1.0alpha7.train.229.ent1_0", "type": "protein-family", "text": [ "importin beta" ], "offsets": [ [ 156, 169 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR040122" } ] } ]

[]

[ { "id": "1.0alpha7.train.229.coref0", "entity_ids": [ "1.0alpha7.train.229.ent0_0" ] }, { "id": "1.0alpha7.train.229.coref1", "entity_ids": [ "1.0alpha7.train.229.ent1_0" ] } ]

[ { "id": "1.0alpha7.train.229.rel0s1.0alpha7.train.229.ent0_0.o1.0alpha7.train.229.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.229.ent0_0", "arg2_id": "1.0alpha7.train.229.ent1_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.230.sent", "type": "sentence", "text": [ "In addition, we show that the gelsolin S1 peptide PS1 does not hinder binding of cofilin or PS2 to F-actin; this also argues against the model proposed by Hatanaka et al. ( 24)." ], "offsets": [ [ 0, 177 ] ] } ]

[ { "id": "1.0alpha7.train.230.ent0_0", "type": "experimental-construct", "text": [ "gelsolin S1" ], "offsets": [ [ 30, 41 ] ], "normalized": [] }, { "id": "1.0alpha7.train.230.ent1_0", "type": "protein", "text": [ "F-actin" ], "offsets": [ [ 99, 106 ] ], "normalized": [] }, { "id": "1.0alpha7.train.230.ent2_0", "type": "protein", "text": [ "gelsolin" ], "offsets": [ [ 30, 38 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2934" }, { "db_name": "hgnc", "db_id": "GSN" }, { "db_name": "uniprot", "db_id": "P06396" } ] }, { "id": "1.0alpha7.train.230.ent3_0", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 101, 106 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR004000" } ] }, { "id": "1.0alpha7.train.230.ent4_0", "type": "experimental-construct", "text": [ "PS2" ], "offsets": [ [ 92, 95 ] ], "normalized": [] }, { "id": "1.0alpha7.train.230.ent5_0", "type": "protein", "text": [ "cofilin" ], "offsets": [ [ 81, 88 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1072" }, { "db_name": "hgnc", "db_id": "CFL1" }, { "db_name": "uniprot", "db_id": "P23528" } ] }, { "id": "1.0alpha7.train.230.ent6_0", "type": "experimental-construct", "text": [ "PS1" ], "offsets": [ [ 50, 53 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.230.coref0", "entity_ids": [ "1.0alpha7.train.230.ent0_0" ] }, { "id": "1.0alpha7.train.230.coref1", "entity_ids": [ "1.0alpha7.train.230.ent1_0" ] }, { "id": "1.0alpha7.train.230.coref2", "entity_ids": [ "1.0alpha7.train.230.ent2_0" ] }, { "id": "1.0alpha7.train.230.coref3", "entity_ids": [ "1.0alpha7.train.230.ent3_0" ] }, { "id": "1.0alpha7.train.230.coref4", "entity_ids": [ "1.0alpha7.train.230.ent4_0" ] }, { "id": "1.0alpha7.train.230.coref5", "entity_ids": [ "1.0alpha7.train.230.ent5_0" ] }, { "id": "1.0alpha7.train.230.coref6", "entity_ids": [ "1.0alpha7.train.230.ent6_0" ] } ]

[ { "id": "1.0alpha7.train.230.rel0s1.0alpha7.train.230.ent1_0.o1.0alpha7.train.230.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.230.ent1_0", "arg2_id": "1.0alpha7.train.230.ent5_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.231.sent", "type": "sentence", "text": [ "Furthermore, it has been shown that GSK-3beta phosphorylates APC and that the phosphorylation enhances the binding of APC to beta-catenin ( 37)." ], "offsets": [ [ 0, 144 ] ] } ]

[ { "id": "1.0alpha7.train.231.ent0_0", "type": "protein", "text": [ "APC" ], "offsets": [ [ 61, 64 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "324" }, { "db_name": "hgnc", "db_id": "APC" } ] }, { "id": "1.0alpha7.train.231.ent1_1", "type": "protein", "text": [ "APC" ], "offsets": [ [ 118, 121 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "324" }, { "db_name": "hgnc", "db_id": "APC" } ] }, { "id": "1.0alpha7.train.231.ent2_0", "type": "protein", "text": [ "GSK-3beta" ], "offsets": [ [ 36, 45 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2932" }, { "db_name": "hgnc", "db_id": "GSK3B" }, { "db_name": "uniprot", "db_id": "P49841" } ] }, { "id": "1.0alpha7.train.231.ent3_0", "type": "protein", "text": [ "beta-catenin" ], "offsets": [ [ 125, 137 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1499" }, { "db_name": "hgnc", "db_id": "CTNNB1" }, { "db_name": "uniprot", "db_id": "P35222" } ] } ]

[]

[ { "id": "1.0alpha7.train.231.coref0", "entity_ids": [ "1.0alpha7.train.231.ent0_0", "1.0alpha7.train.231.ent1_1" ] }, { "id": "1.0alpha7.train.231.coref1", "entity_ids": [ "1.0alpha7.train.231.ent2_0" ] }, { "id": "1.0alpha7.train.231.coref2", "entity_ids": [ "1.0alpha7.train.231.ent3_0" ] } ]

[ { "id": "1.0alpha7.train.231.rel0s1.0alpha7.train.231.ent0_0.o1.0alpha7.train.231.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.231.ent0_0", "arg2_id": "1.0alpha7.train.231.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.231.rel0s1.0alpha7.train.231.ent1_1.o1.0alpha7.train.231.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.231.ent1_1", "arg2_id": "1.0alpha7.train.231.ent3_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.232.sent", "type": "sentence", "text": [ "Binding of FasL to Fas or cross-linking Fas with agonistic antibodies (IgM class anti-Fas antibody, or IgG3 class anti-APO1 antibody) induces apoptosis in Fas-bearing cells (Trauth et al., 1989 ; Yonehara et al., 1989 ; Itoh et al., 1991 )." ], "offsets": [ [ 0, 240 ] ] } ]

[ { "id": "1.0alpha7.train.232.ent0_0", "type": "protein", "text": [ "FasL" ], "offsets": [ [ 11, 15 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "356" }, { "db_name": "hgnc", "db_id": "FASLG" }, { "db_name": "uniprot", "db_id": "P48023" } ] }, { "id": "1.0alpha7.train.232.ent1_0", "type": "protein", "text": [ "Fas" ], "offsets": [ [ 19, 22 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "355" }, { "db_name": "hgnc", "db_id": "FAS" }, { "db_name": "uniprot", "db_id": "P25445" } ] }, { "id": "1.0alpha7.train.232.ent2_1", "type": "protein", "text": [ "Fas" ], "offsets": [ [ 40, 43 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "355" }, { "db_name": "hgnc", "db_id": "FAS" }, { "db_name": "uniprot", "db_id": "P25445" } ] }, { "id": "1.0alpha7.train.232.ent3_2", "type": "protein", "text": [ "Fas" ], "offsets": [ [ 86, 89 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "355" }, { "db_name": "hgnc", "db_id": "FAS" }, { "db_name": "uniprot", "db_id": "P25445" } ] }, { "id": "1.0alpha7.train.232.ent4_3", "type": "protein", "text": [ "Fas" ], "offsets": [ [ 155, 158 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "355" }, { "db_name": "hgnc", "db_id": "FAS" }, { "db_name": "uniprot", "db_id": "P25445" } ] }, { "id": "1.0alpha7.train.232.ent5_0", "type": "reagent", "text": [ "anti-APO1 antibody" ], "offsets": [ [ 114, 132 ] ], "normalized": [] }, { "id": "1.0alpha7.train.232.ent6_0", "type": "reagent", "text": [ "IgG3" ], "offsets": [ [ 103, 107 ] ], "normalized": [] }, { "id": "1.0alpha7.train.232.ent7_0", "type": "reagent", "text": [ "anti-Fas antibody" ], "offsets": [ [ 81, 98 ] ], "normalized": [] }, { "id": "1.0alpha7.train.232.ent8_0", "type": "reagent", "text": [ "IgM" ], "offsets": [ [ 71, 74 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.232.coref0", "entity_ids": [ "1.0alpha7.train.232.ent0_0" ] }, { "id": "1.0alpha7.train.232.coref1", "entity_ids": [ "1.0alpha7.train.232.ent1_0", "1.0alpha7.train.232.ent2_1", "1.0alpha7.train.232.ent3_2", "1.0alpha7.train.232.ent4_3" ] }, { "id": "1.0alpha7.train.232.coref2", "entity_ids": [ "1.0alpha7.train.232.ent5_0" ] }, { "id": "1.0alpha7.train.232.coref3", "entity_ids": [ "1.0alpha7.train.232.ent6_0" ] }, { "id": "1.0alpha7.train.232.coref4", "entity_ids": [ "1.0alpha7.train.232.ent7_0" ] }, { "id": "1.0alpha7.train.232.coref5", "entity_ids": [ "1.0alpha7.train.232.ent8_0" ] } ]

[ { "id": "1.0alpha7.train.232.rel0s1.0alpha7.train.232.ent0_0.o1.0alpha7.train.232.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.232.ent0_0", "arg2_id": "1.0alpha7.train.232.ent1_0", "normalized": [] }, { "id": "1.0alpha7.train.232.rel0s1.0alpha7.train.232.ent0_0.o1.0alpha7.train.232.ent2_1", "type": "bind", "arg1_id": "1.0alpha7.train.232.ent0_0", "arg2_id": "1.0alpha7.train.232.ent2_1", "normalized": [] }, { "id": "1.0alpha7.train.232.rel0s1.0alpha7.train.232.ent0_0.o1.0alpha7.train.232.ent3_2", "type": "bind", "arg1_id": "1.0alpha7.train.232.ent0_0", "arg2_id": "1.0alpha7.train.232.ent3_2", "normalized": [] }, { "id": "1.0alpha7.train.232.rel0s1.0alpha7.train.232.ent0_0.o1.0alpha7.train.232.ent4_3", "type": "bind", "arg1_id": "1.0alpha7.train.232.ent0_0", "arg2_id": "1.0alpha7.train.232.ent4_3", "normalized": [] } ]

[ { "id": "1.0alpha7.train.233.sent", "type": "sentence", "text": [ "( B) ELISA demonstrating the reduced binding of the Ab to BDNF after modification with the caging group and its successful reactivation by UV light." ], "offsets": [ [ 0, 148 ] ] } ]

[ { "id": "1.0alpha7.train.233.ent0_0", "type": "protein", "text": [ "BDNF" ], "offsets": [ [ 58, 62 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "627" }, { "db_name": "hgnc", "db_id": "BDNF" } ] }, { "id": "1.0alpha7.train.233.ent1_0", "type": "process", "text": [ "UV" ], "offsets": [ [ 139, 141 ] ], "normalized": [] }, { "id": "1.0alpha7.train.233.ent2_0", "type": "assay", "text": [ "ELISA" ], "offsets": [ [ 5, 10 ] ], "normalized": [] }, { "id": "1.0alpha7.train.233.ent3_0", "type": "reagent", "text": [ "Ab" ], "offsets": [ [ 52, 54 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.233.coref0", "entity_ids": [ "1.0alpha7.train.233.ent0_0" ] }, { "id": "1.0alpha7.train.233.coref1", "entity_ids": [ "1.0alpha7.train.233.ent1_0" ] }, { "id": "1.0alpha7.train.233.coref2", "entity_ids": [ "1.0alpha7.train.233.ent2_0" ] }, { "id": "1.0alpha7.train.233.coref3", "entity_ids": [ "1.0alpha7.train.233.ent3_0" ] } ]

[]

[ { "id": "1.0alpha7.train.234.sent", "type": "sentence", "text": [ "Immunoprecipitation of p53 was followed by Western blot analysis to determine the type and level of Mdm2 bound to p53 under each of these conditions." ], "offsets": [ [ 0, 149 ] ] } ]

[ { "id": "1.0alpha7.train.234.ent0_0", "type": "protein", "text": [ "Mdm2" ], "offsets": [ [ 100, 104 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4193" }, { "db_name": "hgnc", "db_id": "MDM2" }, { "db_name": "uniprot", "db_id": "E7EPE2" } ] }, { "id": "1.0alpha7.train.234.ent1_0", "type": "protein", "text": [ "p53" ], "offsets": [ [ 23, 26 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7157" }, { "db_name": "hgnc", "db_id": "TP53" }, { "db_name": "uniprot", "db_id": "P04637" } ] }, { "id": "1.0alpha7.train.234.ent2_1", "type": "protein", "text": [ "p53" ], "offsets": [ [ 114, 117 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7157" }, { "db_name": "hgnc", "db_id": "TP53" }, { "db_name": "uniprot", "db_id": "P04637" } ] } ]

[]

[ { "id": "1.0alpha7.train.234.coref0", "entity_ids": [ "1.0alpha7.train.234.ent0_0" ] }, { "id": "1.0alpha7.train.234.coref1", "entity_ids": [ "1.0alpha7.train.234.ent1_0", "1.0alpha7.train.234.ent2_1" ] } ]

[ { "id": "1.0alpha7.train.234.rel0s1.0alpha7.train.234.ent0_0.o1.0alpha7.train.234.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.234.ent0_0", "arg2_id": "1.0alpha7.train.234.ent1_0", "normalized": [] }, { "id": "1.0alpha7.train.234.rel0s1.0alpha7.train.234.ent0_0.o1.0alpha7.train.234.ent2_1", "type": "bind", "arg1_id": "1.0alpha7.train.234.ent0_0", "arg2_id": "1.0alpha7.train.234.ent2_1", "normalized": [] } ]

[ { "id": "1.0alpha7.train.235.sent", "type": "sentence", "text": [ "Binding of E1A to CBP amino acids 1805-1891 prevents binding of the histone acetyltransferase P/CAF, whereas E1A binding to CBP amino acids 2058-2163 prevents binding of the co-activator P/CIP ( 5, 12)." ], "offsets": [ [ 0, 202 ] ] } ]

[ { "id": "1.0alpha7.train.235.ent0_0", "type": "protein", "text": [ "E1A" ], "offsets": [ [ 11, 14 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P03255" } ] }, { "id": "1.0alpha7.train.235.ent1_1", "type": "protein", "text": [ "E1A" ], "offsets": [ [ 109, 112 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P03255" } ] }, { "id": "1.0alpha7.train.235.ent2_0", "type": "protein", "text": [ "CBP" ], "offsets": [ [ 18, 21 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1387" }, { "db_name": "hgnc", "db_id": "CREBBP" }, { "db_name": "uniprot", "db_id": "Q92793" } ] }, { "id": "1.0alpha7.train.235.ent3_1", "type": "protein", "text": [ "CBP" ], "offsets": [ [ 124, 127 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1387" }, { "db_name": "hgnc", "db_id": "CREBBP" }, { "db_name": "uniprot", "db_id": "Q92793" } ] }, { "id": "1.0alpha7.train.235.ent4_0", "type": "protein", "text": [ "P/CIP" ], "offsets": [ [ 187, 192 ] ], "normalized": [] }, { "id": "1.0alpha7.train.235.ent5_0", "type": "protein", "text": [ "histone acetyltransferase P/CAF" ], "offsets": [ [ 68, 99 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8850" }, { "db_name": "hgnc", "db_id": "KAT2B" }, { "db_name": "uniprot", "db_id": "Q92831" } ] } ]

[]

[ { "id": "1.0alpha7.train.235.coref0", "entity_ids": [ "1.0alpha7.train.235.ent0_0", "1.0alpha7.train.235.ent1_1" ] }, { "id": "1.0alpha7.train.235.coref1", "entity_ids": [ "1.0alpha7.train.235.ent2_0", "1.0alpha7.train.235.ent3_1" ] }, { "id": "1.0alpha7.train.235.coref2", "entity_ids": [ "1.0alpha7.train.235.ent4_0" ] }, { "id": "1.0alpha7.train.235.coref3", "entity_ids": [ "1.0alpha7.train.235.ent5_0" ] } ]

[ { "id": "1.0alpha7.train.235.rel0s1.0alpha7.train.235.ent0_0.o1.0alpha7.train.235.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.235.ent0_0", "arg2_id": "1.0alpha7.train.235.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.235.rel0s1.0alpha7.train.235.ent0_0.o1.0alpha7.train.235.ent3_1", "type": "bind", "arg1_id": "1.0alpha7.train.235.ent0_0", "arg2_id": "1.0alpha7.train.235.ent3_1", "normalized": [] }, { "id": "1.0alpha7.train.235.rel0s1.0alpha7.train.235.ent1_1.o1.0alpha7.train.235.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.235.ent1_1", "arg2_id": "1.0alpha7.train.235.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.235.rel0s1.0alpha7.train.235.ent1_1.o1.0alpha7.train.235.ent3_1", "type": "bind", "arg1_id": "1.0alpha7.train.235.ent1_1", "arg2_id": "1.0alpha7.train.235.ent3_1", "normalized": [] } ]

[ { "id": "1.0alpha7.train.236.sent", "type": "sentence", "text": [ "As expected, conversion of the TAGA element into a consensus TATA box increased f:TFIID binding to the LRP-2 promoter, leading to increased protection of the TATA box region and downstream promoter sequences (Fig. 4 B, comparelanes 1–4 with lanes 5–8). " ], "offsets": [ [ 0, 253 ] ] } ]

[ { "id": "1.0alpha7.train.236.ent0_0", "type": "DNA", "text": [ "TATA box" ], "offsets": [ [ 61, 69 ] ], "normalized": [] }, { "id": "1.0alpha7.train.236.ent1_1", "type": "DNA", "text": [ "TATA box" ], "offsets": [ [ 158, 166 ] ], "normalized": [] }, { "id": "1.0alpha7.train.236.ent2_0", "type": "DNA", "text": [ "LRP-2 promoter" ], "offsets": [ [ 103, 117 ] ], "normalized": [] }, { "id": "1.0alpha7.train.236.ent3_0", "type": "experiment-tag", "text": [ "f" ], "offsets": [ [ 80, 81 ] ], "normalized": [] }, { "id": "1.0alpha7.train.236.ent4_0", "type": "fusion-protein", "text": [ "f:TFIID" ], "offsets": [ [ 80, 87 ] ], "normalized": [] }, { "id": "1.0alpha7.train.236.ent5_0", "type": "protein", "text": [ "TFIID" ], "offsets": [ [ 82, 87 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6908" }, { "db_name": "hgnc", "db_id": "TBP" }, { "db_name": "uniprot", "db_id": "P20226" } ] }, { "id": "1.0alpha7.train.236.ent6_0", "type": "DNA", "text": [ "TAGA element" ], "offsets": [ [ 31, 43 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.236.coref0", "entity_ids": [ "1.0alpha7.train.236.ent0_0", "1.0alpha7.train.236.ent1_1" ] }, { "id": "1.0alpha7.train.236.coref1", "entity_ids": [ "1.0alpha7.train.236.ent2_0" ] }, { "id": "1.0alpha7.train.236.coref2", "entity_ids": [ "1.0alpha7.train.236.ent3_0" ] }, { "id": "1.0alpha7.train.236.coref3", "entity_ids": [ "1.0alpha7.train.236.ent4_0" ] }, { "id": "1.0alpha7.train.236.coref4", "entity_ids": [ "1.0alpha7.train.236.ent5_0" ] }, { "id": "1.0alpha7.train.236.coref5", "entity_ids": [ "1.0alpha7.train.236.ent6_0" ] } ]

[ { "id": "1.0alpha7.train.236.rel0s1.0alpha7.train.236.ent2_0.o1.0alpha7.train.236.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.236.ent2_0", "arg2_id": "1.0alpha7.train.236.ent4_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.237.sent", "type": "sentence", "text": [ "The mutation replacing Ser-39 with Ala eliminated the phosphorylation-dependent regulation of actin binding of fascin, indicating that phosphorylation at this site regulates the actin binding ability of fascin." ], "offsets": [ [ 0, 210 ] ] } ]

[ { "id": "1.0alpha7.train.237.ent0_0", "type": "protein", "text": [ "fascin" ], "offsets": [ [ 111, 117 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6624" }, { "db_name": "hgnc", "db_id": "FSCN1" }, { "db_name": "uniprot", "db_id": "C9JPH9" } ] }, { "id": "1.0alpha7.train.237.ent1_1", "type": "protein", "text": [ "fascin" ], "offsets": [ [ 203, 209 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6624" }, { "db_name": "hgnc", "db_id": "FSCN1" }, { "db_name": "uniprot", "db_id": "C9JPH9" } ] }, { "id": "1.0alpha7.train.237.ent2_0", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 94, 99 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] }, { "id": "1.0alpha7.train.237.ent3_1", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 178, 183 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] } ]

[]

[ { "id": "1.0alpha7.train.237.coref0", "entity_ids": [ "1.0alpha7.train.237.ent0_0", "1.0alpha7.train.237.ent1_1" ] }, { "id": "1.0alpha7.train.237.coref1", "entity_ids": [ "1.0alpha7.train.237.ent2_0", "1.0alpha7.train.237.ent3_1" ] } ]

[ { "id": "1.0alpha7.train.237.rel0s1.0alpha7.train.237.ent0_0.o1.0alpha7.train.237.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.237.ent0_0", "arg2_id": "1.0alpha7.train.237.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.237.rel0s1.0alpha7.train.237.ent0_0.o1.0alpha7.train.237.ent3_1", "type": "bind", "arg1_id": "1.0alpha7.train.237.ent0_0", "arg2_id": "1.0alpha7.train.237.ent3_1", "normalized": [] }, { "id": "1.0alpha7.train.237.rel0s1.0alpha7.train.237.ent1_1.o1.0alpha7.train.237.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.237.ent1_1", "arg2_id": "1.0alpha7.train.237.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.237.rel0s1.0alpha7.train.237.ent1_1.o1.0alpha7.train.237.ent3_1", "type": "bind", "arg1_id": "1.0alpha7.train.237.ent1_1", "arg2_id": "1.0alpha7.train.237.ent3_1", "normalized": [] } ]

[ { "id": "1.0alpha7.train.238.sent", "type": "sentence", "text": [ "Slit significantly increased the binding of srGAP1 to Robo1 ( Figure 4C, lane 2, compared to lane 1)." ], "offsets": [ [ 0, 101 ] ] } ]

[ { "id": "1.0alpha7.train.238.ent0_0", "type": "protein", "text": [ "Robo1" ], "offsets": [ [ 54, 59 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6091" }, { "db_name": "hgnc", "db_id": "ROBO1" }, { "db_name": "uniprot", "db_id": "Q9Y6N7" } ] }, { "id": "1.0alpha7.train.238.ent1_0", "type": "protein", "text": [ "Slit" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6585" }, { "db_name": "hgnc", "db_id": "SLIT1" }, { "db_name": "uniprot", "db_id": "O75093" } ] }, { "id": "1.0alpha7.train.238.ent2_0", "type": "protein", "text": [ "srGAP1" ], "offsets": [ [ 44, 50 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "57522" }, { "db_name": "hgnc", "db_id": "SRGAP1" }, { "db_name": "uniprot", "db_id": "Q7Z6B7" } ] } ]

[]

[ { "id": "1.0alpha7.train.238.coref0", "entity_ids": [ "1.0alpha7.train.238.ent0_0" ] }, { "id": "1.0alpha7.train.238.coref1", "entity_ids": [ "1.0alpha7.train.238.ent1_0" ] }, { "id": "1.0alpha7.train.238.coref2", "entity_ids": [ "1.0alpha7.train.238.ent2_0" ] } ]

[ { "id": "1.0alpha7.train.238.rel0s1.0alpha7.train.238.ent0_0.o1.0alpha7.train.238.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.238.ent0_0", "arg2_id": "1.0alpha7.train.238.ent2_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.239.sent", "type": "sentence", "text": [ "The heparin-binding property of apoE plays an important role in the sequestration step of the heparan sulfate proteoglycan (HSPG)/ LRP metabolic pathway as well as in the independent HSPG pathway [ 5." ], "offsets": [ [ 0, 200 ] ] } ]

[ { "id": "1.0alpha7.train.239.ent0_0", "type": "chemical", "text": [ "heparin" ], "offsets": [ [ 4, 11 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "772" } ] }, { "id": "1.0alpha7.train.239.ent1_0", "type": "chemical", "text": [ "HSPG" ], "offsets": [ [ 124, 128 ] ], "normalized": [ { "db_name": "pubchem:substance", "db_id": "53789512" } ] }, { "id": "1.0alpha7.train.239.ent2_1", "type": "chemical", "text": [ "HSPG" ], "offsets": [ [ 183, 187 ] ], "normalized": [ { "db_name": "pubchem:substance", "db_id": "53789512" } ] }, { "id": "1.0alpha7.train.239.ent3_0", "type": "chemical", "text": [ "heparan sulfate proteoglycan" ], "offsets": [ [ 94, 122 ] ], "normalized": [ { "db_name": "pubchem:substance", "db_id": "53789512" } ] }, { "id": "1.0alpha7.train.239.ent4_0", "type": "protein", "text": [ "apoE" ], "offsets": [ [ 32, 36 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "348" }, { "db_name": "hgnc", "db_id": "APOE" }, { "db_name": "uniprot", "db_id": "P02649" } ] }, { "id": "1.0alpha7.train.239.ent5_0", "type": "protein-family", "text": [ "LRP" ], "offsets": [ [ 131, 134 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR019330" } ] } ]

[]

[ { "id": "1.0alpha7.train.239.coref0", "entity_ids": [ "1.0alpha7.train.239.ent0_0" ] }, { "id": "1.0alpha7.train.239.coref1", "entity_ids": [ "1.0alpha7.train.239.ent1_0", "1.0alpha7.train.239.ent2_1", "1.0alpha7.train.239.ent3_0" ] }, { "id": "1.0alpha7.train.239.coref2", "entity_ids": [ "1.0alpha7.train.239.ent4_0" ] }, { "id": "1.0alpha7.train.239.coref3", "entity_ids": [ "1.0alpha7.train.239.ent5_0" ] } ]

[ { "id": "1.0alpha7.train.239.rel0s1.0alpha7.train.239.ent0_0.o1.0alpha7.train.239.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.239.ent0_0", "arg2_id": "1.0alpha7.train.239.ent4_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.240.sent", "type": "sentence", "text": [ "Full-length p21, which binds to both Cdk-cyclin and PCNA, effectively inhibits DNA replication (Fig. 7 A), whereas GST control protein is not inhibitory." ], "offsets": [ [ 0, 153 ] ] } ]

[ { "id": "1.0alpha7.train.240.ent0_0", "type": "protein", "text": [ "PCNA" ], "offsets": [ [ 52, 56 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5111" }, { "db_name": "hgnc", "db_id": "PCNA" }, { "db_name": "uniprot", "db_id": "P12004" } ] }, { "id": "1.0alpha7.train.240.ent1_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 79, 82 ] ], "normalized": [] }, { "id": "1.0alpha7.train.240.ent2_0", "type": "protein-complex", "text": [ "Cdk-cyclin" ], "offsets": [ [ 37, 47 ] ], "normalized": [] }, { "id": "1.0alpha7.train.240.ent3_0", "type": "protein", "text": [ "p21" ], "offsets": [ [ 12, 15 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1026" }, { "db_name": "hgnc", "db_id": "CDKN1A" }, { "db_name": "uniprot", "db_id": "P38936" } ] }, { "id": "1.0alpha7.train.240.ent4_0", "type": "protein-family", "text": [ "GST" ], "offsets": [ [ 115, 118 ] ], "normalized": [ { "db_name": "intenz", "db_id": "https://www.ebi.ac.uk/intenz/query?cmd" } ] } ]

[]

[ { "id": "1.0alpha7.train.240.coref0", "entity_ids": [ "1.0alpha7.train.240.ent0_0" ] }, { "id": "1.0alpha7.train.240.coref1", "entity_ids": [ "1.0alpha7.train.240.ent1_0" ] }, { "id": "1.0alpha7.train.240.coref2", "entity_ids": [ "1.0alpha7.train.240.ent2_0" ] }, { "id": "1.0alpha7.train.240.coref3", "entity_ids": [ "1.0alpha7.train.240.ent3_0" ] }, { "id": "1.0alpha7.train.240.coref4", "entity_ids": [ "1.0alpha7.train.240.ent4_0" ] } ]

[ { "id": "1.0alpha7.train.240.rel0s1.0alpha7.train.240.ent2_0.o1.0alpha7.train.240.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.240.ent2_0", "arg2_id": "1.0alpha7.train.240.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.240.rel1s1.0alpha7.train.240.ent0_0.o1.0alpha7.train.240.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.240.ent0_0", "arg2_id": "1.0alpha7.train.240.ent3_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.241.sent", "type": "sentence", "text": [ "Thus several different mutations that disrupt calcium binding and calcium-dependent syntaxin 1A binding to the C2A domain of synaptotagmin 1 do not reverse the inhibitory effect of microinjected C2A fragments on calcium-regulated secretion from PC12 cells." ], "offsets": [ [ 0, 256 ] ] } ]

[ { "id": "1.0alpha7.train.241.ent0_0", "type": "protein", "text": [ "syntaxin 1A" ], "offsets": [ [ 84, 95 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6804" }, { "db_name": "hgnc", "db_id": "STX1A" }, { "db_name": "uniprot", "db_id": "Q16623" } ] }, { "id": "1.0alpha7.train.241.ent1_0", "type": "cell", "text": [ "PC12" ], "offsets": [ [ 245, 249 ] ], "normalized": [] }, { "id": "1.0alpha7.train.241.ent2_0", "type": "protein", "text": [ "synaptotagmin 1" ], "offsets": [ [ 125, 140 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6857" }, { "db_name": "hgnc", "db_id": "SYT1" }, { "db_name": "uniprot", "db_id": "P21579" } ] }, { "id": "1.0alpha7.train.241.ent3_0", "type": "chemical", "text": [ "calcium" ], "offsets": [ [ 46, 53 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5460341" } ] }, { "id": "1.0alpha7.train.241.ent4_1", "type": "chemical", "text": [ "calcium" ], "offsets": [ [ 66, 73 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5460341" } ] }, { "id": "1.0alpha7.train.241.ent5_2", "type": "chemical", "text": [ "calcium" ], "offsets": [ [ 212, 219 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5460341" } ] }, { "id": "1.0alpha7.train.241.ent6_0", "type": "reagent", "text": [ "C2A fragments" ], "offsets": [ [ 195, 208 ] ], "normalized": [] }, { "id": "1.0alpha7.train.241.ent7_0", "type": "protein-domain", "text": [ "C2A domain" ], "offsets": [ [ 111, 121 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.241.coref0", "entity_ids": [ "1.0alpha7.train.241.ent0_0" ] }, { "id": "1.0alpha7.train.241.coref1", "entity_ids": [ "1.0alpha7.train.241.ent1_0" ] }, { "id": "1.0alpha7.train.241.coref2", "entity_ids": [ "1.0alpha7.train.241.ent2_0" ] }, { "id": "1.0alpha7.train.241.coref3", "entity_ids": [ "1.0alpha7.train.241.ent3_0", "1.0alpha7.train.241.ent4_1", "1.0alpha7.train.241.ent5_2" ] }, { "id": "1.0alpha7.train.241.coref4", "entity_ids": [ "1.0alpha7.train.241.ent6_0" ] }, { "id": "1.0alpha7.train.241.coref5", "entity_ids": [ "1.0alpha7.train.241.ent7_0" ] } ]

[ { "id": "1.0alpha7.train.241.rel0s1.0alpha7.train.241.ent2_0.o1.0alpha7.train.241.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.241.ent2_0", "arg2_id": "1.0alpha7.train.241.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.241.rel0s1.0alpha7.train.241.ent2_0.o1.0alpha7.train.241.ent4_1", "type": "bind", "arg1_id": "1.0alpha7.train.241.ent2_0", "arg2_id": "1.0alpha7.train.241.ent4_1", "normalized": [] }, { "id": "1.0alpha7.train.241.rel0s1.0alpha7.train.241.ent2_0.o1.0alpha7.train.241.ent5_2", "type": "bind", "arg1_id": "1.0alpha7.train.241.ent2_0", "arg2_id": "1.0alpha7.train.241.ent5_2", "normalized": [] }, { "id": "1.0alpha7.train.241.rel1s1.0alpha7.train.241.ent0_0.o1.0alpha7.train.241.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.241.ent0_0", "arg2_id": "1.0alpha7.train.241.ent2_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.242.sent", "type": "sentence", "text": [ "The relative proportion of TBP bound to GST-TADIV of the total present in the crude extract (Fig. 2) was found to be about 1/10 of that of the TAFIIs as determined by densitometric analysis (data not shown)." ], "offsets": [ [ 0, 207 ] ] } ]

[ { "id": "1.0alpha7.train.242.ent0_0", "type": "protein-family", "text": [ "TAFIIs" ], "offsets": [ [ 143, 149 ] ], "normalized": [] }, { "id": "1.0alpha7.train.242.ent1_0", "type": "protein", "text": [ "TBP" ], "offsets": [ [ 27, 30 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6908" }, { "db_name": "hgnc", "db_id": "TBP" }, { "db_name": "uniprot", "db_id": "P20226" } ] }, { "id": "1.0alpha7.train.242.ent2_0", "type": "fusion-protein", "text": [ "GST-TADIV" ], "offsets": [ [ 40, 49 ] ], "normalized": [] }, { "id": "1.0alpha7.train.242.ent3_0", "type": "DNA", "text": [ "TADIV" ], "offsets": [ [ 44, 49 ] ], "normalized": [] }, { "id": "1.0alpha7.train.242.ent4_0", "type": "experiment-tag", "text": [ "GST" ], "offsets": [ [ 40, 43 ] ], "normalized": [ { "db_name": "intenz", "db_id": "2.5.1.18" } ] } ]

[]

[ { "id": "1.0alpha7.train.242.coref0", "entity_ids": [ "1.0alpha7.train.242.ent0_0" ] }, { "id": "1.0alpha7.train.242.coref1", "entity_ids": [ "1.0alpha7.train.242.ent1_0" ] }, { "id": "1.0alpha7.train.242.coref2", "entity_ids": [ "1.0alpha7.train.242.ent2_0" ] }, { "id": "1.0alpha7.train.242.coref3", "entity_ids": [ "1.0alpha7.train.242.ent3_0" ] }, { "id": "1.0alpha7.train.242.coref4", "entity_ids": [ "1.0alpha7.train.242.ent4_0" ] } ]

[ { "id": "1.0alpha7.train.242.rel0s1.0alpha7.train.242.ent1_0.o1.0alpha7.train.242.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.242.ent1_0", "arg2_id": "1.0alpha7.train.242.ent2_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.243.sent", "type": "sentence", "text": [ "These findings suggest a complex reciprocal relationship between regulation of adducin function by calmodulin binding and phosphorylation by PKA and PKC." ], "offsets": [ [ 0, 153 ] ] } ]

[ { "id": "1.0alpha7.train.243.ent0_0", "type": "protein-family", "text": [ "PKC" ], "offsets": [ [ 149, 152 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR014376" } ] }, { "id": "1.0alpha7.train.243.ent1_0", "type": "protein-complex", "text": [ "PKA" ], "offsets": [ [ 141, 144 ] ], "normalized": [ { "db_name": "intenz", "db_id": "https://www.ebi.ac.uk/intenz/query?cmd" } ] }, { "id": "1.0alpha7.train.243.ent2_0", "type": "protein", "text": [ "calmodulin" ], "offsets": [ [ 99, 109 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "801" }, { "db_name": "hgnc", "db_id": "CALM1" }, { "db_name": "uniprot", "db_id": "P0DP23" } ] }, { "id": "1.0alpha7.train.243.ent3_0", "type": "protein", "text": [ "adducin" ], "offsets": [ [ 79, 86 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "118" }, { "db_name": "hgnc", "db_id": "ADD1" }, { "db_name": "uniprot", "db_id": "P35611" } ] } ]

[]

[ { "id": "1.0alpha7.train.243.coref0", "entity_ids": [ "1.0alpha7.train.243.ent0_0" ] }, { "id": "1.0alpha7.train.243.coref1", "entity_ids": [ "1.0alpha7.train.243.ent1_0" ] }, { "id": "1.0alpha7.train.243.coref2", "entity_ids": [ "1.0alpha7.train.243.ent2_0" ] }, { "id": "1.0alpha7.train.243.coref3", "entity_ids": [ "1.0alpha7.train.243.ent3_0" ] } ]

[ { "id": "1.0alpha7.train.243.rel0s1.0alpha7.train.243.ent2_0.o1.0alpha7.train.243.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.243.ent2_0", "arg2_id": "1.0alpha7.train.243.ent3_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.244.sent", "type": "sentence", "text": [ "At present, we do not know whether Arp11 binds directly to Arp1 or actin." ], "offsets": [ [ 0, 73 ] ] } ]

[ { "id": "1.0alpha7.train.244.ent0_0", "type": "protein", "text": [ "Arp1" ], "offsets": [ [ 59, 63 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "10121" }, { "db_name": "hgnc", "db_id": "ACTR1A" }, { "db_name": "uniprot", "db_id": "P61163" } ] }, { "id": "1.0alpha7.train.244.ent1_0", "type": "protein", "text": [ "Arp11" ], "offsets": [ [ 35, 40 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "55860" }, { "db_name": "hgnc", "db_id": "ACTR10" }, { "db_name": "uniprot", "db_id": "Q9NZ32" } ] }, { "id": "1.0alpha7.train.244.ent2_0", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 67, 72 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] } ]

[]

[ { "id": "1.0alpha7.train.244.coref0", "entity_ids": [ "1.0alpha7.train.244.ent0_0" ] }, { "id": "1.0alpha7.train.244.coref1", "entity_ids": [ "1.0alpha7.train.244.ent1_0" ] }, { "id": "1.0alpha7.train.244.coref2", "entity_ids": [ "1.0alpha7.train.244.ent2_0" ] } ]

[]

[ { "id": "1.0alpha7.train.245.sent", "type": "sentence", "text": [ "In vivo binding of hAxin to APC, -catenin and GSK3 ." ], "offsets": [ [ 0, 52 ] ] } ]

[ { "id": "1.0alpha7.train.245.ent0_0", "type": "protein", "text": [ "APC" ], "offsets": [ [ 28, 31 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "324" }, { "db_name": "hgnc", "db_id": "APC" } ] }, { "id": "1.0alpha7.train.245.ent1_0", "type": "protein", "text": [ "hAxin" ], "offsets": [ [ 19, 24 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8312" }, { "db_name": "hgnc", "db_id": "AXIN1" }, { "db_name": "uniprot", "db_id": "O15169" } ] }, { "id": "1.0alpha7.train.245.ent2_0", "type": "protein", "text": [ "catenin" ], "offsets": [ [ 34, 41 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1495" }, { "db_name": "hgnc", "db_id": "CTNNA1" }, { "db_name": "uniprot", "db_id": "P35221" } ] }, { "id": "1.0alpha7.train.245.ent3_0", "type": "protein", "text": [ "GSK3" ], "offsets": [ [ 46, 50 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2931" }, { "db_name": "hgnc", "db_id": "GSK3A" }, { "db_name": "uniprot", "db_id": "P49840" } ] } ]

[]

[ { "id": "1.0alpha7.train.245.coref0", "entity_ids": [ "1.0alpha7.train.245.ent0_0" ] }, { "id": "1.0alpha7.train.245.coref1", "entity_ids": [ "1.0alpha7.train.245.ent1_0" ] }, { "id": "1.0alpha7.train.245.coref2", "entity_ids": [ "1.0alpha7.train.245.ent2_0" ] }, { "id": "1.0alpha7.train.245.coref3", "entity_ids": [ "1.0alpha7.train.245.ent3_0" ] } ]

[ { "id": "1.0alpha7.train.245.rel0s1.0alpha7.train.245.ent0_0.o1.0alpha7.train.245.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.245.ent0_0", "arg2_id": "1.0alpha7.train.245.ent1_0", "normalized": [] }, { "id": "1.0alpha7.train.245.rel1s1.0alpha7.train.245.ent1_0.o1.0alpha7.train.245.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.245.ent1_0", "arg2_id": "1.0alpha7.train.245.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.245.rel2s1.0alpha7.train.245.ent1_0.o1.0alpha7.train.245.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.245.ent1_0", "arg2_id": "1.0alpha7.train.245.ent3_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.246.sent", "type": "sentence", "text": [ "The ATP-bound form of Hsp70 binds and releases peptides rapidly, whereas the ADP-bound form binds and releases them slowly (Palleros et al., 1991 ; Schmid et al., 1994 ; Szabo et al., 1994 )." ], "offsets": [ [ 0, 191 ] ] } ]

[ { "id": "1.0alpha7.train.246.ent0_0", "type": "protein", "text": [ "Hsp70" ], "offsets": [ [ 22, 27 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3308" }, { "db_name": "hgnc", "db_id": "HSPA4" }, { "db_name": "uniprot", "db_id": "P34932" } ] }, { "id": "1.0alpha7.train.246.ent1_0", "type": "protein", "text": [ "ADP-bound form" ], "offsets": [ [ 77, 91 ] ], "normalized": [] }, { "id": "1.0alpha7.train.246.ent2_0", "type": "protein", "text": [ "ATP-bound form of Hsp70" ], "offsets": [ [ 4, 27 ] ], "normalized": [] }, { "id": "1.0alpha7.train.246.ent3_0", "type": "chemical", "text": [ "ADP" ], "offsets": [ [ 77, 80 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "6022" } ] }, { "id": "1.0alpha7.train.246.ent4_0", "type": "chemical", "text": [ "ATP" ], "offsets": [ [ 4, 7 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5957" } ] } ]

[]

[ { "id": "1.0alpha7.train.246.coref0", "entity_ids": [ "1.0alpha7.train.246.ent0_0" ] }, { "id": "1.0alpha7.train.246.coref1", "entity_ids": [ "1.0alpha7.train.246.ent1_0" ] }, { "id": "1.0alpha7.train.246.coref2", "entity_ids": [ "1.0alpha7.train.246.ent2_0" ] }, { "id": "1.0alpha7.train.246.coref3", "entity_ids": [ "1.0alpha7.train.246.ent3_0" ] }, { "id": "1.0alpha7.train.246.coref4", "entity_ids": [ "1.0alpha7.train.246.ent4_0" ] } ]

[ { "id": "1.0alpha7.train.246.rel0s1.0alpha7.train.246.ent0_0.o1.0alpha7.train.246.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.246.ent0_0", "arg2_id": "1.0alpha7.train.246.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.246.rel1s1.0alpha7.train.246.ent0_0.o1.0alpha7.train.246.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.246.ent0_0", "arg2_id": "1.0alpha7.train.246.ent3_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.247.sent", "type": "sentence", "text": [ "To confirm the specificity for interaction between EID-1 and Rb in vivo, we tested the binding of endogenous Rb to wild-type EID-1 versus the C180G mutation in transfected mammalian cells." ], "offsets": [ [ 0, 188 ] ] } ]

[ { "id": "1.0alpha7.train.247.ent0_0", "type": "protein", "text": [ "EID-1" ], "offsets": [ [ 51, 56 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "23741" }, { "db_name": "hgnc", "db_id": "EID1" }, { "db_name": "uniprot", "db_id": "Q9Y6B2" } ] }, { "id": "1.0alpha7.train.247.ent1_1", "type": "protein", "text": [ "EID-1" ], "offsets": [ [ 125, 130 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "23741" }, { "db_name": "hgnc", "db_id": "EID1" }, { "db_name": "uniprot", "db_id": "Q9Y6B2" } ] }, { "id": "1.0alpha7.train.247.ent2_0", "type": "protein", "text": [ "Rb" ], "offsets": [ [ 61, 63 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5925" }, { "db_name": "hgnc", "db_id": "RB1" }, { "db_name": "uniprot", "db_id": "P06400" } ] }, { "id": "1.0alpha7.train.247.ent3_1", "type": "protein", "text": [ "Rb" ], "offsets": [ [ 109, 111 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5925" }, { "db_name": "hgnc", "db_id": "RB1" }, { "db_name": "uniprot", "db_id": "P06400" } ] } ]

[]

[ { "id": "1.0alpha7.train.247.coref0", "entity_ids": [ "1.0alpha7.train.247.ent0_0", "1.0alpha7.train.247.ent1_1" ] }, { "id": "1.0alpha7.train.247.coref1", "entity_ids": [ "1.0alpha7.train.247.ent2_0", "1.0alpha7.train.247.ent3_1" ] } ]

[ { "id": "1.0alpha7.train.247.rel0s1.0alpha7.train.247.ent0_0.o1.0alpha7.train.247.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.247.ent0_0", "arg2_id": "1.0alpha7.train.247.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.247.rel0s1.0alpha7.train.247.ent0_0.o1.0alpha7.train.247.ent3_1", "type": "bind", "arg1_id": "1.0alpha7.train.247.ent0_0", "arg2_id": "1.0alpha7.train.247.ent3_1", "normalized": [] }, { "id": "1.0alpha7.train.247.rel0s1.0alpha7.train.247.ent1_1.o1.0alpha7.train.247.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.247.ent1_1", "arg2_id": "1.0alpha7.train.247.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.247.rel0s1.0alpha7.train.247.ent1_1.o1.0alpha7.train.247.ent3_1", "type": "bind", "arg1_id": "1.0alpha7.train.247.ent1_1", "arg2_id": "1.0alpha7.train.247.ent3_1", "normalized": [] } ]

[ { "id": "1.0alpha7.train.248.sent", "type": "sentence", "text": [ "None of the mutations affected the binding of APC11 to APC2 (our unpublished data)." ], "offsets": [ [ 0, 83 ] ] } ]

[ { "id": "1.0alpha7.train.248.ent0_0", "type": "protein", "text": [ "APC2" ], "offsets": [ [ 55, 59 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "10297" }, { "db_name": "hgnc", "db_id": "APC2" } ] }, { "id": "1.0alpha7.train.248.ent1_0", "type": "protein", "text": [ "APC11" ], "offsets": [ [ 46, 51 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "51529" }, { "db_name": "hgnc", "db_id": "ANAPC11" }, { "db_name": "uniprot", "db_id": "Q9NYG5" } ] } ]

[]

[ { "id": "1.0alpha7.train.248.coref0", "entity_ids": [ "1.0alpha7.train.248.ent0_0" ] }, { "id": "1.0alpha7.train.248.coref1", "entity_ids": [ "1.0alpha7.train.248.ent1_0" ] } ]

[ { "id": "1.0alpha7.train.248.rel0s1.0alpha7.train.248.ent0_0.o1.0alpha7.train.248.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.248.ent0_0", "arg2_id": "1.0alpha7.train.248.ent1_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.249.sent", "type": "sentence", "text": [ "In parallel control experiments, all TRP tails failed to bind INAD from InaDP215 head extracts." ], "offsets": [ [ 0, 95 ] ] } ]

[ { "id": "1.0alpha7.train.249.ent0_0", "type": "protein-family", "text": [ "TRP" ], "offsets": [ [ 37, 40 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR010308" } ] }, { "id": "1.0alpha7.train.249.ent1_0", "type": "protein", "text": [ "INAD" ], "offsets": [ [ 62, 66 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q24008" } ] }, { "id": "1.0alpha7.train.249.ent2_0", "type": "gene", "text": [ "InaDP215" ], "offsets": [ [ 72, 80 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.249.coref0", "entity_ids": [ "1.0alpha7.train.249.ent0_0" ] }, { "id": "1.0alpha7.train.249.coref1", "entity_ids": [ "1.0alpha7.train.249.ent1_0" ] }, { "id": "1.0alpha7.train.249.coref2", "entity_ids": [ "1.0alpha7.train.249.ent2_0" ] } ]

[ { "id": "1.0alpha7.train.249.rel0s1.0alpha7.train.249.ent0_0.o1.0alpha7.train.249.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.249.ent0_0", "arg2_id": "1.0alpha7.train.249.ent1_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.250.sent", "type": "sentence", "text": [ "Interestingly, we saw strong binding of Gal4 to the GC-rich region, even in the absence of galactose, which agrees with previous work by others, showing that the transcriptional activity of Gal4 is not regulated by its DNA-binding activity but rather by the action of Gal80 and Gal3 (for examples, see references 7 and 31)." ], "offsets": [ [ 0, 323 ] ] } ]

[ { "id": "1.0alpha7.train.250.ent0_0", "type": "protein", "text": [ "Gal4" ], "offsets": [ [ 40, 44 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3960" }, { "db_name": "hgnc", "db_id": "LGALS4" }, { "db_name": "uniprot", "db_id": "P56470" } ] }, { "id": "1.0alpha7.train.250.ent1_1", "type": "protein", "text": [ "Gal4" ], "offsets": [ [ 190, 194 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3960" }, { "db_name": "hgnc", "db_id": "LGALS4" }, { "db_name": "uniprot", "db_id": "P56470" } ] }, { "id": "1.0alpha7.train.250.ent2_0", "type": "chemical", "text": [ "galactose" ], "offsets": [ [ 91, 100 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "6036" } ] }, { "id": "1.0alpha7.train.250.ent3_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 219, 222 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.250.ent4_0", "type": "protein", "text": [ "Gal3" ], "offsets": [ [ 278, 282 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P13045" } ] }, { "id": "1.0alpha7.train.250.ent5_0", "type": "protein", "text": [ "Gal80" ], "offsets": [ [ 268, 273 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P04387" } ] }, { "id": "1.0alpha7.train.250.ent6_0", "type": "DNA", "text": [ "GC-rich region" ], "offsets": [ [ 52, 66 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.250.coref0", "entity_ids": [ "1.0alpha7.train.250.ent0_0", "1.0alpha7.train.250.ent1_1" ] }, { "id": "1.0alpha7.train.250.coref1", "entity_ids": [ "1.0alpha7.train.250.ent2_0" ] }, { "id": "1.0alpha7.train.250.coref2", "entity_ids": [ "1.0alpha7.train.250.ent3_0" ] }, { "id": "1.0alpha7.train.250.coref3", "entity_ids": [ "1.0alpha7.train.250.ent4_0" ] }, { "id": "1.0alpha7.train.250.coref4", "entity_ids": [ "1.0alpha7.train.250.ent5_0" ] }, { "id": "1.0alpha7.train.250.coref5", "entity_ids": [ "1.0alpha7.train.250.ent6_0" ] } ]

[ { "id": "1.0alpha7.train.250.rel0s1.0alpha7.train.250.ent0_0.o1.0alpha7.train.250.ent6_0", "type": "bind", "arg1_id": "1.0alpha7.train.250.ent0_0", "arg2_id": "1.0alpha7.train.250.ent6_0", "normalized": [] }, { "id": "1.0alpha7.train.250.rel0s1.0alpha7.train.250.ent1_1.o1.0alpha7.train.250.ent6_0", "type": "bind", "arg1_id": "1.0alpha7.train.250.ent1_1", "arg2_id": "1.0alpha7.train.250.ent6_0", "normalized": [] }, { "id": "1.0alpha7.train.250.rel1s1.0alpha7.train.250.ent0_0.o1.0alpha7.train.250.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.250.ent0_0", "arg2_id": "1.0alpha7.train.250.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.250.rel1s1.0alpha7.train.250.ent1_1.o1.0alpha7.train.250.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.250.ent1_1", "arg2_id": "1.0alpha7.train.250.ent3_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.251.sent", "type": "sentence", "text": [ "Blockade of either VASP binding to ActA ( Smith et al. 1996 ) or Profilin binding to VASP ( Kang et al. 1997 ) impairs Listeria motility, implying a role for Profilin in accelerating the actin-dependent motility." ], "offsets": [ [ 0, 212 ] ] } ]

[ { "id": "1.0alpha7.train.251.ent0_0", "type": "protein", "text": [ "ActA" ], "offsets": [ [ 35, 39 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "58" }, { "db_name": "hgnc", "db_id": "ACTA1" }, { "db_name": "uniprot", "db_id": "P68133" } ] }, { "id": "1.0alpha7.train.251.ent1_0", "type": "protein", "text": [ "VASP" ], "offsets": [ [ 19, 23 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7408" }, { "db_name": "hgnc", "db_id": "VASP" }, { "db_name": "uniprot", "db_id": "P50552" } ] }, { "id": "1.0alpha7.train.251.ent2_1", "type": "protein", "text": [ "VASP" ], "offsets": [ [ 85, 89 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7408" }, { "db_name": "hgnc", "db_id": "VASP" }, { "db_name": "uniprot", "db_id": "P50552" } ] }, { "id": "1.0alpha7.train.251.ent3_0", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 187, 192 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] }, { "id": "1.0alpha7.train.251.ent4_0", "type": "protein-family", "text": [ "Profilin" ], "offsets": [ [ 65, 73 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR005455" } ] }, { "id": "1.0alpha7.train.251.ent5_1", "type": "protein-family", "text": [ "Profilin" ], "offsets": [ [ 158, 166 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR005455" } ] } ]

[]

[ { "id": "1.0alpha7.train.251.coref0", "entity_ids": [ "1.0alpha7.train.251.ent0_0" ] }, { "id": "1.0alpha7.train.251.coref1", "entity_ids": [ "1.0alpha7.train.251.ent1_0", "1.0alpha7.train.251.ent2_1" ] }, { "id": "1.0alpha7.train.251.coref2", "entity_ids": [ "1.0alpha7.train.251.ent3_0" ] }, { "id": "1.0alpha7.train.251.coref3", "entity_ids": [ "1.0alpha7.train.251.ent4_0", "1.0alpha7.train.251.ent5_1" ] } ]

[ { "id": "1.0alpha7.train.251.rel0s1.0alpha7.train.251.ent0_0.o1.0alpha7.train.251.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.251.ent0_0", "arg2_id": "1.0alpha7.train.251.ent1_0", "normalized": [] }, { "id": "1.0alpha7.train.251.rel0s1.0alpha7.train.251.ent0_0.o1.0alpha7.train.251.ent2_1", "type": "bind", "arg1_id": "1.0alpha7.train.251.ent0_0", "arg2_id": "1.0alpha7.train.251.ent2_1", "normalized": [] }, { "id": "1.0alpha7.train.251.rel1s1.0alpha7.train.251.ent1_0.o1.0alpha7.train.251.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.251.ent1_0", "arg2_id": "1.0alpha7.train.251.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.251.rel1s1.0alpha7.train.251.ent1_0.o1.0alpha7.train.251.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.251.ent1_0", "arg2_id": "1.0alpha7.train.251.ent5_1", "normalized": [] }, { "id": "1.0alpha7.train.251.rel1s1.0alpha7.train.251.ent2_1.o1.0alpha7.train.251.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.251.ent2_1", "arg2_id": "1.0alpha7.train.251.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.251.rel1s1.0alpha7.train.251.ent2_1.o1.0alpha7.train.251.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.251.ent2_1", "arg2_id": "1.0alpha7.train.251.ent5_1", "normalized": [] } ]

[ { "id": "1.0alpha7.train.252.sent", "type": "sentence", "text": [ "The presence of similar motifs to those found in all known GTPases suggests that menin could similarly exhibit GTP binding activity as well as GTP-hydrolyzing activity." ], "offsets": [ [ 0, 168 ] ] } ]

[ { "id": "1.0alpha7.train.252.ent0_0", "type": "protein", "text": [ "menin" ], "offsets": [ [ 81, 86 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4221" }, { "db_name": "hgnc", "db_id": "MEN1" }, { "db_name": "uniprot", "db_id": "O00255" } ] }, { "id": "1.0alpha7.train.252.ent1_0", "type": "chemical", "text": [ "GTP" ], "offsets": [ [ 111, 114 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "135398633" } ] }, { "id": "1.0alpha7.train.252.ent2_1", "type": "chemical", "text": [ "GTP" ], "offsets": [ [ 143, 146 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "135398633" } ] }, { "id": "1.0alpha7.train.252.ent3_0", "type": "protein-family", "text": [ "GTPases" ], "offsets": [ [ 59, 66 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.252.coref0", "entity_ids": [ "1.0alpha7.train.252.ent0_0" ] }, { "id": "1.0alpha7.train.252.coref1", "entity_ids": [ "1.0alpha7.train.252.ent1_0", "1.0alpha7.train.252.ent2_1" ] }, { "id": "1.0alpha7.train.252.coref2", "entity_ids": [ "1.0alpha7.train.252.ent3_0" ] } ]

[ { "id": "1.0alpha7.train.252.rel0s1.0alpha7.train.252.ent0_0.o1.0alpha7.train.252.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.252.ent0_0", "arg2_id": "1.0alpha7.train.252.ent1_0", "normalized": [] }, { "id": "1.0alpha7.train.252.rel0s1.0alpha7.train.252.ent0_0.o1.0alpha7.train.252.ent2_1", "type": "bind", "arg1_id": "1.0alpha7.train.252.ent0_0", "arg2_id": "1.0alpha7.train.252.ent2_1", "normalized": [] }, { "id": "1.0alpha7.train.252.rel1s1.0alpha7.train.252.ent1_0.o1.0alpha7.train.252.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.252.ent1_0", "arg2_id": "1.0alpha7.train.252.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.252.rel1s1.0alpha7.train.252.ent2_1.o1.0alpha7.train.252.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.252.ent2_1", "arg2_id": "1.0alpha7.train.252.ent3_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.254.sent", "type": "sentence", "text": [ "The finding that SLB can bind to Lhx3 and Lhx4 suggests a possible role in modulating transcription." ], "offsets": [ [ 0, 100 ] ] } ]

[ { "id": "1.0alpha7.train.254.ent0_0", "type": "protein", "text": [ "Lhx3" ], "offsets": [ [ 33, 37 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8022" }, { "db_name": "hgnc", "db_id": "LHX3" }, { "db_name": "uniprot", "db_id": "Q9UBR4" } ] }, { "id": "1.0alpha7.train.254.ent1_0", "type": "protein", "text": [ "Lhx4" ], "offsets": [ [ 42, 46 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "89884" }, { "db_name": "hgnc", "db_id": "LHX4" }, { "db_name": "uniprot", "db_id": "Q969G2" } ] }, { "id": "1.0alpha7.train.254.ent2_0", "type": "protein", "text": [ "SLB" ], "offsets": [ [ 17, 20 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "26160" }, { "db_name": "hgnc", "db_id": "IFT172" }, { "db_name": "uniprot", "db_id": "Q9UG01" } ] } ]

[]

[ { "id": "1.0alpha7.train.254.coref0", "entity_ids": [ "1.0alpha7.train.254.ent0_0" ] }, { "id": "1.0alpha7.train.254.coref1", "entity_ids": [ "1.0alpha7.train.254.ent1_0" ] }, { "id": "1.0alpha7.train.254.coref2", "entity_ids": [ "1.0alpha7.train.254.ent2_0" ] } ]

[ { "id": "1.0alpha7.train.254.rel0s1.0alpha7.train.254.ent0_0.o1.0alpha7.train.254.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.254.ent0_0", "arg2_id": "1.0alpha7.train.254.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.254.rel1s1.0alpha7.train.254.ent1_0.o1.0alpha7.train.254.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.254.ent1_0", "arg2_id": "1.0alpha7.train.254.ent2_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.255.sent", "type": "sentence", "text": [ "We show that Hsp70 binding is regulated by the phosphorylation state of the turn motif, one of the two conserved carboxyl-terminal phosphorylation sites, and that Hsp70 binds mature PKC that has become dephosphorylated, rather than newly synthesized PKC that has yet to be phosphorylated." ], "offsets": [ [ 0, 288 ] ] } ]

[ { "id": "1.0alpha7.train.255.ent0_0", "type": "protein", "text": [ "Hsp70" ], "offsets": [ [ 13, 18 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3308" }, { "db_name": "hgnc", "db_id": "HSPA4" }, { "db_name": "uniprot", "db_id": "P34932" } ] }, { "id": "1.0alpha7.train.255.ent1_1", "type": "protein", "text": [ "Hsp70" ], "offsets": [ [ 163, 168 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3308" }, { "db_name": "hgnc", "db_id": "HSPA4" }, { "db_name": "uniprot", "db_id": "P34932" } ] }, { "id": "1.0alpha7.train.255.ent2_0", "type": "protein-family", "text": [ "PKC" ], "offsets": [ [ 182, 185 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR014376" } ] }, { "id": "1.0alpha7.train.255.ent3_1", "type": "protein-family", "text": [ "PKC" ], "offsets": [ [ 250, 253 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR014376" } ] } ]

[]

[ { "id": "1.0alpha7.train.255.coref0", "entity_ids": [ "1.0alpha7.train.255.ent0_0", "1.0alpha7.train.255.ent1_1" ] }, { "id": "1.0alpha7.train.255.coref1", "entity_ids": [ "1.0alpha7.train.255.ent2_0", "1.0alpha7.train.255.ent3_1" ] } ]

[ { "id": "1.0alpha7.train.255.rel0s1.0alpha7.train.255.ent0_0.o1.0alpha7.train.255.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.255.ent0_0", "arg2_id": "1.0alpha7.train.255.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.255.rel0s1.0alpha7.train.255.ent0_0.o1.0alpha7.train.255.ent3_1", "type": "bind", "arg1_id": "1.0alpha7.train.255.ent0_0", "arg2_id": "1.0alpha7.train.255.ent3_1", "normalized": [] }, { "id": "1.0alpha7.train.255.rel0s1.0alpha7.train.255.ent1_1.o1.0alpha7.train.255.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.255.ent1_1", "arg2_id": "1.0alpha7.train.255.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.255.rel0s1.0alpha7.train.255.ent1_1.o1.0alpha7.train.255.ent3_1", "type": "bind", "arg1_id": "1.0alpha7.train.255.ent1_1", "arg2_id": "1.0alpha7.train.255.ent3_1", "normalized": [] } ]

[ { "id": "1.0alpha7.train.256.sent", "type": "sentence", "text": [ "However, affinity chromatography experiments showed that Tm bound to acidic TnT with a greater affinity than to basic TnT, consistent with the significantly higher maximal binding of acidic TnT to Tm in solid phase binding assays." ], "offsets": [ [ 0, 230 ] ] } ]

[ { "id": "1.0alpha7.train.256.ent0_0", "type": "protein", "text": [ "TnT" ], "offsets": [ [ 76, 79 ] ], "normalized": [] }, { "id": "1.0alpha7.train.256.ent1_1", "type": "protein", "text": [ "TnT" ], "offsets": [ [ 118, 121 ] ], "normalized": [] }, { "id": "1.0alpha7.train.256.ent2_2", "type": "protein", "text": [ "TnT" ], "offsets": [ [ 190, 193 ] ], "normalized": [] }, { "id": "1.0alpha7.train.256.ent3_0", "type": "protein", "text": [ "basic TnT" ], "offsets": [ [ 112, 121 ] ], "normalized": [] }, { "id": "1.0alpha7.train.256.ent4_0", "type": "protein", "text": [ "Tm" ], "offsets": [ [ 57, 59 ] ], "normalized": [] }, { "id": "1.0alpha7.train.256.ent5_1", "type": "protein", "text": [ "Tm" ], "offsets": [ [ 197, 199 ] ], "normalized": [] }, { "id": "1.0alpha7.train.256.ent6_0", "type": "protein", "text": [ "acidic TnT" ], "offsets": [ [ 69, 79 ] ], "normalized": [] }, { "id": "1.0alpha7.train.256.ent7_1", "type": "protein", "text": [ "acidic TnT" ], "offsets": [ [ 183, 193 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.256.coref0", "entity_ids": [ "1.0alpha7.train.256.ent0_0", "1.0alpha7.train.256.ent1_1", "1.0alpha7.train.256.ent2_2" ] }, { "id": "1.0alpha7.train.256.coref1", "entity_ids": [ "1.0alpha7.train.256.ent3_0" ] }, { "id": "1.0alpha7.train.256.coref2", "entity_ids": [ "1.0alpha7.train.256.ent4_0", "1.0alpha7.train.256.ent5_1" ] }, { "id": "1.0alpha7.train.256.coref3", "entity_ids": [ "1.0alpha7.train.256.ent6_0", "1.0alpha7.train.256.ent7_1" ] } ]

[ { "id": "1.0alpha7.train.256.rel0s1.0alpha7.train.256.ent0_0.o1.0alpha7.train.256.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.256.ent0_0", "arg2_id": "1.0alpha7.train.256.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.256.rel0s1.0alpha7.train.256.ent0_0.o1.0alpha7.train.256.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.256.ent0_0", "arg2_id": "1.0alpha7.train.256.ent5_1", "normalized": [] }, { "id": "1.0alpha7.train.256.rel0s1.0alpha7.train.256.ent1_1.o1.0alpha7.train.256.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.256.ent1_1", "arg2_id": "1.0alpha7.train.256.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.256.rel0s1.0alpha7.train.256.ent1_1.o1.0alpha7.train.256.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.256.ent1_1", "arg2_id": "1.0alpha7.train.256.ent5_1", "normalized": [] }, { "id": "1.0alpha7.train.256.rel0s1.0alpha7.train.256.ent2_2.o1.0alpha7.train.256.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.256.ent2_2", "arg2_id": "1.0alpha7.train.256.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.256.rel0s1.0alpha7.train.256.ent2_2.o1.0alpha7.train.256.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.256.ent2_2", "arg2_id": "1.0alpha7.train.256.ent5_1", "normalized": [] } ]

[ { "id": "1.0alpha7.train.257.sent", "type": "sentence", "text": [ "Ca2+-Dependent Binding of Syntaxin 1a to the C2A Domain Demonstrated by 1H-15N HSQC Spectroscopy" ], "offsets": [ [ 0, 96 ] ] } ]

[ { "id": "1.0alpha7.train.257.ent0_0", "type": "assay", "text": [ "1H-15N HSQC Spectroscopy" ], "offsets": [ [ 72, 96 ] ], "normalized": [] }, { "id": "1.0alpha7.train.257.ent1_0", "type": "chemical", "text": [ "Ca2+" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5460341" } ] }, { "id": "1.0alpha7.train.257.ent2_0", "type": "protein-domain", "text": [ "C2A" ], "offsets": [ [ 45, 48 ] ], "normalized": [] }, { "id": "1.0alpha7.train.257.ent3_0", "type": "protein", "text": [ "Syntaxin 1a" ], "offsets": [ [ 26, 37 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6804" }, { "db_name": "hgnc", "db_id": "STX1A" }, { "db_name": "uniprot", "db_id": "Q16623" } ] } ]

[]

[ { "id": "1.0alpha7.train.257.coref0", "entity_ids": [ "1.0alpha7.train.257.ent0_0" ] }, { "id": "1.0alpha7.train.257.coref1", "entity_ids": [ "1.0alpha7.train.257.ent1_0" ] }, { "id": "1.0alpha7.train.257.coref2", "entity_ids": [ "1.0alpha7.train.257.ent2_0" ] }, { "id": "1.0alpha7.train.257.coref3", "entity_ids": [ "1.0alpha7.train.257.ent3_0" ] } ]

[ { "id": "1.0alpha7.train.257.rel0s1.0alpha7.train.257.ent1_0.o1.0alpha7.train.257.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.257.ent1_0", "arg2_id": "1.0alpha7.train.257.ent3_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.258.sent", "type": "sentence", "text": [ "Adducin is a membrane skeleton protein originally described in human erythrocytes that promotes the binding of spectrin to actin and also binds directly to actin and bundles actin filaments." ], "offsets": [ [ 0, 190 ] ] } ]

[ { "id": "1.0alpha7.train.258.ent0_0", "type": "protein-complex", "text": [ "spectrin" ], "offsets": [ [ 111, 119 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR002017" } ] }, { "id": "1.0alpha7.train.258.ent1_0", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 123, 128 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] }, { "id": "1.0alpha7.train.258.ent2_1", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 156, 161 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] }, { "id": "1.0alpha7.train.258.ent3_2", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 174, 179 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] }, { "id": "1.0alpha7.train.258.ent4_0", "type": "protein", "text": [ "Adducin" ], "offsets": [ [ 0, 7 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.258.coref0", "entity_ids": [ "1.0alpha7.train.258.ent0_0" ] }, { "id": "1.0alpha7.train.258.coref1", "entity_ids": [ "1.0alpha7.train.258.ent1_0", "1.0alpha7.train.258.ent2_1", "1.0alpha7.train.258.ent3_2" ] }, { "id": "1.0alpha7.train.258.coref2", "entity_ids": [ "1.0alpha7.train.258.ent4_0" ] } ]

[ { "id": "1.0alpha7.train.258.rel0s1.0alpha7.train.258.ent1_0.o1.0alpha7.train.258.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.258.ent1_0", "arg2_id": "1.0alpha7.train.258.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.258.rel0s1.0alpha7.train.258.ent2_1.o1.0alpha7.train.258.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.258.ent2_1", "arg2_id": "1.0alpha7.train.258.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.258.rel0s1.0alpha7.train.258.ent3_2.o1.0alpha7.train.258.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.258.ent3_2", "arg2_id": "1.0alpha7.train.258.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.258.rel1s1.0alpha7.train.258.ent0_0.o1.0alpha7.train.258.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.258.ent0_0", "arg2_id": "1.0alpha7.train.258.ent1_0", "normalized": [] }, { "id": "1.0alpha7.train.258.rel1s1.0alpha7.train.258.ent0_0.o1.0alpha7.train.258.ent2_1", "type": "bind", "arg1_id": "1.0alpha7.train.258.ent0_0", "arg2_id": "1.0alpha7.train.258.ent2_1", "normalized": [] }, { "id": "1.0alpha7.train.258.rel1s1.0alpha7.train.258.ent0_0.o1.0alpha7.train.258.ent3_2", "type": "bind", "arg1_id": "1.0alpha7.train.258.ent0_0", "arg2_id": "1.0alpha7.train.258.ent3_2", "normalized": [] } ]

[ { "id": "1.0alpha7.train.259.sent", "type": "sentence", "text": [ "In conjunction with peptide-binding and genetic studies, atomic modeling of fimbrin binding to F-actin strongly suggests that the F-actin-binding residues in the CH domain are concentrated in its C-terminal portion ( 23)." ], "offsets": [ [ 0, 221 ] ] } ]

[ { "id": "1.0alpha7.train.259.ent0_0", "type": "protein", "text": [ "fimbrin" ], "offsets": [ [ 76, 83 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5357" }, { "db_name": "hgnc", "db_id": "PLS1" }, { "db_name": "uniprot", "db_id": "Q14651" } ] }, { "id": "1.0alpha7.train.259.ent1_0", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 97, 102 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR004000" } ] }, { "id": "1.0alpha7.train.259.ent2_1", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 132, 137 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR004000" } ] }, { "id": "1.0alpha7.train.259.ent3_0", "type": "protein-domain", "text": [ "CH domain" ], "offsets": [ [ 162, 171 ] ], "normalized": [] }, { "id": "1.0alpha7.train.259.ent4_0", "type": "protein", "text": [ "F-actin" ], "offsets": [ [ 95, 102 ] ], "normalized": [] }, { "id": "1.0alpha7.train.259.ent5_1", "type": "protein", "text": [ "F-actin" ], "offsets": [ [ 130, 137 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.259.coref0", "entity_ids": [ "1.0alpha7.train.259.ent0_0" ] }, { "id": "1.0alpha7.train.259.coref1", "entity_ids": [ "1.0alpha7.train.259.ent1_0", "1.0alpha7.train.259.ent2_1" ] }, { "id": "1.0alpha7.train.259.coref2", "entity_ids": [ "1.0alpha7.train.259.ent3_0" ] }, { "id": "1.0alpha7.train.259.coref3", "entity_ids": [ "1.0alpha7.train.259.ent4_0", "1.0alpha7.train.259.ent5_1" ] } ]

[ { "id": "1.0alpha7.train.259.rel0s1.0alpha7.train.259.ent0_0.o1.0alpha7.train.259.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.259.ent0_0", "arg2_id": "1.0alpha7.train.259.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.259.rel0s1.0alpha7.train.259.ent0_0.o1.0alpha7.train.259.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.259.ent0_0", "arg2_id": "1.0alpha7.train.259.ent5_1", "normalized": [] } ]

[ { "id": "1.0alpha7.train.260.sent", "type": "sentence", "text": [ "Comparison of the Ral-binding surface of Sec5 with the region of GDI that interacts with Rho family G proteins shows that the contacts between Sec5-Ral and GDI-Cdc42 are significantly different." ], "offsets": [ [ 0, 194 ] ] } ]

[ { "id": "1.0alpha7.train.260.ent0_0", "type": "protein", "text": [ "GDI" ], "offsets": [ [ 65, 68 ] ], "normalized": [] }, { "id": "1.0alpha7.train.260.ent1_1", "type": "protein", "text": [ "GDI" ], "offsets": [ [ 156, 159 ] ], "normalized": [] }, { "id": "1.0alpha7.train.260.ent2_0", "type": "protein", "text": [ "Ral" ], "offsets": [ [ 18, 21 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5898" }, { "db_name": "hgnc", "db_id": "RALA" }, { "db_name": "uniprot", "db_id": "P11233" } ] }, { "id": "1.0alpha7.train.260.ent3_1", "type": "protein", "text": [ "Ral" ], "offsets": [ [ 148, 151 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5898" }, { "db_name": "hgnc", "db_id": "RALA" }, { "db_name": "uniprot", "db_id": "P11233" } ] }, { "id": "1.0alpha7.train.260.ent4_0", "type": "protein", "text": [ "Sec5" ], "offsets": [ [ 41, 45 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "55770" }, { "db_name": "hgnc", "db_id": "EXOC2" }, { "db_name": "uniprot", "db_id": "Q96KP1" } ] }, { "id": "1.0alpha7.train.260.ent5_1", "type": "protein", "text": [ "Sec5" ], "offsets": [ [ 143, 147 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "55770" }, { "db_name": "hgnc", "db_id": "EXOC2" }, { "db_name": "uniprot", "db_id": "Q96KP1" } ] }, { "id": "1.0alpha7.train.260.ent6_0", "type": "protein-family", "text": [ "Rho family G proteins" ], "offsets": [ [ 89, 110 ] ], "normalized": [] }, { "id": "1.0alpha7.train.260.ent7_0", "type": "protein", "text": [ "Cdc42" ], "offsets": [ [ 160, 165 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "998" }, { "db_name": "hgnc", "db_id": "CDC42" }, { "db_name": "uniprot", "db_id": "P60953" } ] } ]

[]

[ { "id": "1.0alpha7.train.260.coref0", "entity_ids": [ "1.0alpha7.train.260.ent0_0", "1.0alpha7.train.260.ent1_1" ] }, { "id": "1.0alpha7.train.260.coref1", "entity_ids": [ "1.0alpha7.train.260.ent2_0", "1.0alpha7.train.260.ent3_1" ] }, { "id": "1.0alpha7.train.260.coref2", "entity_ids": [ "1.0alpha7.train.260.ent4_0", "1.0alpha7.train.260.ent5_1" ] }, { "id": "1.0alpha7.train.260.coref3", "entity_ids": [ "1.0alpha7.train.260.ent6_0" ] }, { "id": "1.0alpha7.train.260.coref4", "entity_ids": [ "1.0alpha7.train.260.ent7_0" ] } ]

[ { "id": "1.0alpha7.train.260.rel0s1.0alpha7.train.260.ent2_0.o1.0alpha7.train.260.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.260.ent2_0", "arg2_id": "1.0alpha7.train.260.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.260.rel0s1.0alpha7.train.260.ent2_0.o1.0alpha7.train.260.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.260.ent2_0", "arg2_id": "1.0alpha7.train.260.ent5_1", "normalized": [] }, { "id": "1.0alpha7.train.260.rel0s1.0alpha7.train.260.ent3_1.o1.0alpha7.train.260.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.260.ent3_1", "arg2_id": "1.0alpha7.train.260.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.260.rel0s1.0alpha7.train.260.ent3_1.o1.0alpha7.train.260.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.260.ent3_1", "arg2_id": "1.0alpha7.train.260.ent5_1", "normalized": [] }, { "id": "1.0alpha7.train.260.rel1s1.0alpha7.train.260.ent0_0.o1.0alpha7.train.260.ent7_0", "type": "bind", "arg1_id": "1.0alpha7.train.260.ent0_0", "arg2_id": "1.0alpha7.train.260.ent7_0", "normalized": [] }, { "id": "1.0alpha7.train.260.rel1s1.0alpha7.train.260.ent1_1.o1.0alpha7.train.260.ent7_0", "type": "bind", "arg1_id": "1.0alpha7.train.260.ent1_1", "arg2_id": "1.0alpha7.train.260.ent7_0", "normalized": [] }, { "id": "1.0alpha7.train.260.rel2s1.0alpha7.train.260.ent0_0.o1.0alpha7.train.260.ent6_0", "type": "bind", "arg1_id": "1.0alpha7.train.260.ent0_0", "arg2_id": "1.0alpha7.train.260.ent6_0", "normalized": [] }, { "id": "1.0alpha7.train.260.rel2s1.0alpha7.train.260.ent1_1.o1.0alpha7.train.260.ent6_0", "type": "bind", "arg1_id": "1.0alpha7.train.260.ent1_1", "arg2_id": "1.0alpha7.train.260.ent6_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.261.sent", "type": "sentence", "text": [ "The binding sites for Armadillo and Groucho on Tcf do not overlap, but whether or not Armadillo and Groucho bind simultaneously to Tcf is not clear." ], "offsets": [ [ 0, 148 ] ] } ]

[ { "id": "1.0alpha7.train.261.ent0_0", "type": "protein-family", "text": [ "Tcf" ], "offsets": [ [ 47, 50 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR024940" } ] }, { "id": "1.0alpha7.train.261.ent1_1", "type": "protein-family", "text": [ "Tcf" ], "offsets": [ [ 131, 134 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR024940" } ] }, { "id": "1.0alpha7.train.261.ent2_0", "type": "protein", "text": [ "Groucho" ], "offsets": [ [ 36, 43 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P16371" } ] }, { "id": "1.0alpha7.train.261.ent3_1", "type": "protein", "text": [ "Groucho" ], "offsets": [ [ 100, 107 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P16371" } ] }, { "id": "1.0alpha7.train.261.ent4_0", "type": "protein-motif", "text": [ "Armadillo" ], "offsets": [ [ 22, 31 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR000225" } ] }, { "id": "1.0alpha7.train.261.ent5_1", "type": "protein-motif", "text": [ "Armadillo" ], "offsets": [ [ 86, 95 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR000225" } ] } ]

[]

[ { "id": "1.0alpha7.train.261.coref0", "entity_ids": [ "1.0alpha7.train.261.ent0_0", "1.0alpha7.train.261.ent1_1" ] }, { "id": "1.0alpha7.train.261.coref1", "entity_ids": [ "1.0alpha7.train.261.ent2_0", "1.0alpha7.train.261.ent3_1" ] }, { "id": "1.0alpha7.train.261.coref2", "entity_ids": [ "1.0alpha7.train.261.ent4_0", "1.0alpha7.train.261.ent5_1" ] } ]

[ { "id": "1.0alpha7.train.261.rel0s1.0alpha7.train.261.ent0_0.o1.0alpha7.train.261.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.261.ent0_0", "arg2_id": "1.0alpha7.train.261.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.261.rel0s1.0alpha7.train.261.ent0_0.o1.0alpha7.train.261.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.261.ent0_0", "arg2_id": "1.0alpha7.train.261.ent5_1", "normalized": [] }, { "id": "1.0alpha7.train.261.rel0s1.0alpha7.train.261.ent1_1.o1.0alpha7.train.261.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.261.ent1_1", "arg2_id": "1.0alpha7.train.261.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.261.rel0s1.0alpha7.train.261.ent1_1.o1.0alpha7.train.261.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.261.ent1_1", "arg2_id": "1.0alpha7.train.261.ent5_1", "normalized": [] }, { "id": "1.0alpha7.train.261.rel1s1.0alpha7.train.261.ent0_0.o1.0alpha7.train.261.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.261.ent0_0", "arg2_id": "1.0alpha7.train.261.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.261.rel1s1.0alpha7.train.261.ent0_0.o1.0alpha7.train.261.ent3_1", "type": "bind", "arg1_id": "1.0alpha7.train.261.ent0_0", "arg2_id": "1.0alpha7.train.261.ent3_1", "normalized": [] }, { "id": "1.0alpha7.train.261.rel1s1.0alpha7.train.261.ent1_1.o1.0alpha7.train.261.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.261.ent1_1", "arg2_id": "1.0alpha7.train.261.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.261.rel1s1.0alpha7.train.261.ent1_1.o1.0alpha7.train.261.ent3_1", "type": "bind", "arg1_id": "1.0alpha7.train.261.ent1_1", "arg2_id": "1.0alpha7.train.261.ent3_1", "normalized": [] } ]

[ { "id": "1.0alpha7.train.262.sent", "type": "sentence", "text": [ "Specific binding of Sp1 and Smad3 was inhibited with an excess of 100x unlabeled oligonucleotide ( Competitor)." ], "offsets": [ [ 0, 111 ] ] } ]

[ { "id": "1.0alpha7.train.262.ent0_0", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 20, 23 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.262.ent1_0", "type": "protein", "text": [ "Smad3" ], "offsets": [ [ 28, 33 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4088" }, { "db_name": "hgnc", "db_id": "SMAD3" }, { "db_name": "uniprot", "db_id": "P84022" } ] } ]

[]

[ { "id": "1.0alpha7.train.262.coref0", "entity_ids": [ "1.0alpha7.train.262.ent0_0" ] }, { "id": "1.0alpha7.train.262.coref1", "entity_ids": [ "1.0alpha7.train.262.ent1_0" ] } ]

[ { "id": "1.0alpha7.train.262.rel0s1.0alpha7.train.262.ent0_0.o1.0alpha7.train.262.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.262.ent0_0", "arg2_id": "1.0alpha7.train.262.ent1_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.263.sent", "type": "sentence", "text": [ "This indicates that the binding of GSK-3beta to Axin is essential for its activity to degrade beta-catenin, consistent with the observation that AxindeltaGSK-3beta does not enhance the phosphorylation of beta-catenin even in the presence of APC-(1211-2075)." ], "offsets": [ [ 0, 257 ] ] } ]

[ { "id": "1.0alpha7.train.263.ent0_0", "type": "protein", "text": [ "Axin" ], "offsets": [ [ 48, 52 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8312" }, { "db_name": "hgnc", "db_id": "AXIN1" }, { "db_name": "uniprot", "db_id": "O15169" } ] }, { "id": "1.0alpha7.train.263.ent1_0", "type": "protein-complex", "text": [ "AxindeltaGSK-3beta" ], "offsets": [ [ 145, 163 ] ], "normalized": [] }, { "id": "1.0alpha7.train.263.ent2_0", "type": "protein", "text": [ "APC" ], "offsets": [ [ 241, 244 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "324" }, { "db_name": "hgnc", "db_id": "APC" } ] }, { "id": "1.0alpha7.train.263.ent3_0", "type": "protein", "text": [ "APC-(1211-2075)" ], "offsets": [ [ 241, 256 ] ], "normalized": [] }, { "id": "1.0alpha7.train.263.ent4_0", "type": "protein", "text": [ "beta-catenin" ], "offsets": [ [ 94, 106 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1499" }, { "db_name": "hgnc", "db_id": "CTNNB1" }, { "db_name": "uniprot", "db_id": "P35222" } ] }, { "id": "1.0alpha7.train.263.ent5_1", "type": "protein", "text": [ "beta-catenin" ], "offsets": [ [ 204, 216 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1499" }, { "db_name": "hgnc", "db_id": "CTNNB1" }, { "db_name": "uniprot", "db_id": "P35222" } ] }, { "id": "1.0alpha7.train.263.ent6_0", "type": "protein", "text": [ "GSK-3beta" ], "offsets": [ [ 35, 44 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2932" }, { "db_name": "hgnc", "db_id": "GSK3B" }, { "db_name": "uniprot", "db_id": "P49841" } ] } ]

[]

[ { "id": "1.0alpha7.train.263.coref0", "entity_ids": [ "1.0alpha7.train.263.ent0_0" ] }, { "id": "1.0alpha7.train.263.coref1", "entity_ids": [ "1.0alpha7.train.263.ent1_0" ] }, { "id": "1.0alpha7.train.263.coref2", "entity_ids": [ "1.0alpha7.train.263.ent2_0" ] }, { "id": "1.0alpha7.train.263.coref3", "entity_ids": [ "1.0alpha7.train.263.ent3_0" ] }, { "id": "1.0alpha7.train.263.coref4", "entity_ids": [ "1.0alpha7.train.263.ent4_0", "1.0alpha7.train.263.ent5_1" ] }, { "id": "1.0alpha7.train.263.coref5", "entity_ids": [ "1.0alpha7.train.263.ent6_0" ] } ]

[ { "id": "1.0alpha7.train.263.rel0s1.0alpha7.train.263.ent0_0.o1.0alpha7.train.263.ent6_0", "type": "bind", "arg1_id": "1.0alpha7.train.263.ent0_0", "arg2_id": "1.0alpha7.train.263.ent6_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.264.sent", "type": "sentence", "text": [ "N.N. Dewji and S.J. Singer, Specific transcellular binding between membrane proteins crucial to Alzheimer disease." ], "offsets": [ [ 0, 114 ] ] } ]

[]

[]

[]

[]

[ { "id": "1.0alpha7.train.265.sent", "type": "sentence", "text": [ "We tested seven mAbs derived from an HIV-2-infected human for their ability to inhibit SIVmac239 gp120 binding to CCR5rh in HEK293 cells in the presence and absence of sCD4." ], "offsets": [ [ 0, 173 ] ] } ]

[ { "id": "1.0alpha7.train.265.ent0_0", "type": "reagent", "text": [ "mAbs" ], "offsets": [ [ 16, 20 ] ], "normalized": [] }, { "id": "1.0alpha7.train.265.ent1_0", "type": "protein", "text": [ "CCR5rh" ], "offsets": [ [ 114, 120 ] ], "normalized": [] }, { "id": "1.0alpha7.train.265.ent2_0", "type": "protein", "text": [ "sCD4" ], "offsets": [ [ 168, 172 ] ], "normalized": [] }, { "id": "1.0alpha7.train.265.ent3_0", "type": "protein", "text": [ "gp120" ], "offsets": [ [ 97, 102 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P04578" } ] }, { "id": "1.0alpha7.train.265.ent4_0", "type": "cell", "text": [ "SIVmac239" ], "offsets": [ [ 87, 96 ] ], "normalized": [] }, { "id": "1.0alpha7.train.265.ent5_0", "type": "cell", "text": [ "HEK293" ], "offsets": [ [ 124, 130 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.265.coref0", "entity_ids": [ "1.0alpha7.train.265.ent0_0" ] }, { "id": "1.0alpha7.train.265.coref1", "entity_ids": [ "1.0alpha7.train.265.ent1_0" ] }, { "id": "1.0alpha7.train.265.coref2", "entity_ids": [ "1.0alpha7.train.265.ent2_0" ] }, { "id": "1.0alpha7.train.265.coref3", "entity_ids": [ "1.0alpha7.train.265.ent3_0" ] }, { "id": "1.0alpha7.train.265.coref4", "entity_ids": [ "1.0alpha7.train.265.ent4_0" ] }, { "id": "1.0alpha7.train.265.coref5", "entity_ids": [ "1.0alpha7.train.265.ent5_0" ] } ]

[ { "id": "1.0alpha7.train.265.rel0s1.0alpha7.train.265.ent1_0.o1.0alpha7.train.265.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.265.ent1_0", "arg2_id": "1.0alpha7.train.265.ent3_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.266.sent", "type": "sentence", "text": [ "After extensive washing, the amount of MyD118/Gadd45 protein bound to PCNA was assessed using either MyD118- or Gadd45-specific antibodies, which, in turn, were reacted with HRP-coupled secondary antibody." ], "offsets": [ [ 0, 205 ] ] } ]

[ { "id": "1.0alpha7.train.266.ent0_0", "type": "protein", "text": [ "PCNA" ], "offsets": [ [ 70, 74 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5111" }, { "db_name": "hgnc", "db_id": "PCNA" }, { "db_name": "uniprot", "db_id": "P12004" } ] }, { "id": "1.0alpha7.train.266.ent1_0", "type": "protein-family", "text": [ "Gadd45" ], "offsets": [ [ 46, 52 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR024824" } ] }, { "id": "1.0alpha7.train.266.ent2_1", "type": "protein-family", "text": [ "Gadd45" ], "offsets": [ [ 112, 118 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR024824" } ] }, { "id": "1.0alpha7.train.266.ent3_0", "type": "protein", "text": [ "HRP" ], "offsets": [ [ 174, 177 ] ], "normalized": [] }, { "id": "1.0alpha7.train.266.ent4_0", "type": "protein-family", "text": [ "MyD118" ], "offsets": [ [ 39, 45 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR024824" } ] }, { "id": "1.0alpha7.train.266.ent5_1", "type": "protein-family", "text": [ "MyD118" ], "offsets": [ [ 101, 107 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR024824" } ] }, { "id": "1.0alpha7.train.266.ent6_0", "type": "reagent", "text": [ "MyD118-" ], "offsets": [ [ 101, 108 ] ], "normalized": [] }, { "id": "1.0alpha7.train.266.ent7_0", "type": "reagent", "text": [ "Gadd45-specific antibodies" ], "offsets": [ [ 112, 138 ] ], "normalized": [] }, { "id": "1.0alpha7.train.266.ent8_0", "type": "reagent", "text": [ "HRP-coupled secondary antibody" ], "offsets": [ [ 174, 204 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.266.coref0", "entity_ids": [ "1.0alpha7.train.266.ent0_0" ] }, { "id": "1.0alpha7.train.266.coref1", "entity_ids": [ "1.0alpha7.train.266.ent1_0", "1.0alpha7.train.266.ent2_1" ] }, { "id": "1.0alpha7.train.266.coref2", "entity_ids": [ "1.0alpha7.train.266.ent3_0" ] }, { "id": "1.0alpha7.train.266.coref3", "entity_ids": [ "1.0alpha7.train.266.ent4_0", "1.0alpha7.train.266.ent5_1" ] }, { "id": "1.0alpha7.train.266.coref4", "entity_ids": [ "1.0alpha7.train.266.ent6_0" ] }, { "id": "1.0alpha7.train.266.coref5", "entity_ids": [ "1.0alpha7.train.266.ent7_0" ] }, { "id": "1.0alpha7.train.266.coref6", "entity_ids": [ "1.0alpha7.train.266.ent8_0" ] } ]

[ { "id": "1.0alpha7.train.266.rel0s1.0alpha7.train.266.ent0_0.o1.0alpha7.train.266.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.266.ent0_0", "arg2_id": "1.0alpha7.train.266.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.266.rel0s1.0alpha7.train.266.ent0_0.o1.0alpha7.train.266.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.266.ent0_0", "arg2_id": "1.0alpha7.train.266.ent5_1", "normalized": [] }, { "id": "1.0alpha7.train.266.rel1s1.0alpha7.train.266.ent0_0.o1.0alpha7.train.266.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.266.ent0_0", "arg2_id": "1.0alpha7.train.266.ent1_0", "normalized": [] }, { "id": "1.0alpha7.train.266.rel1s1.0alpha7.train.266.ent0_0.o1.0alpha7.train.266.ent2_1", "type": "bind", "arg1_id": "1.0alpha7.train.266.ent0_0", "arg2_id": "1.0alpha7.train.266.ent2_1", "normalized": [] } ]

[ { "id": "1.0alpha7.train.267.sent", "type": "sentence", "text": [ "Given the observation that CRT binds to SL structures with GC-rich stems (7, 16, 24, 27), we searched for the secondary structures with GC-rich stems within the C/EBPα mRNA and found two possible SL organizations containing GC-rich regions within the stem (Fig. ​7B)." ], "offsets": [ [ 0, 267 ] ] } ]

[ { "id": "1.0alpha7.train.267.ent0_0", "type": "DNA", "text": [ "SL structures" ], "offsets": [ [ 40, 53 ] ], "normalized": [] }, { "id": "1.0alpha7.train.267.ent1_0", "type": "DNA", "text": [ "GC-rich stems" ], "offsets": [ [ 59, 72 ] ], "normalized": [] }, { "id": "1.0alpha7.train.267.ent2_1", "type": "DNA", "text": [ "GC-rich stems" ], "offsets": [ [ 136, 149 ] ], "normalized": [] }, { "id": "1.0alpha7.train.267.ent3_0", "type": "protein", "text": [ "CRT" ], "offsets": [ [ 27, 30 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "811" }, { "db_name": "hgnc", "db_id": "CALR" }, { "db_name": "uniprot", "db_id": "P27797" } ] }, { "id": "1.0alpha7.train.267.ent4_0", "type": "RNA", "text": [ "C/EBPα mRNA" ], "offsets": [ [ 161, 172 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.267.coref0", "entity_ids": [ "1.0alpha7.train.267.ent0_0" ] }, { "id": "1.0alpha7.train.267.coref1", "entity_ids": [ "1.0alpha7.train.267.ent1_0", "1.0alpha7.train.267.ent2_1" ] }, { "id": "1.0alpha7.train.267.coref2", "entity_ids": [ "1.0alpha7.train.267.ent3_0" ] }, { "id": "1.0alpha7.train.267.coref3", "entity_ids": [ "1.0alpha7.train.267.ent4_0" ] } ]

[]

[ { "id": "1.0alpha7.train.268.sent", "type": "sentence", "text": [ "These observations strongly suggest that electrostatic interactions provide a main driving force for the Ca2+-dependent binding of the C2A domain to syntaxin." ], "offsets": [ [ 0, 158 ] ] } ]

[ { "id": "1.0alpha7.train.268.ent0_0", "type": "protein-family", "text": [ "syntaxin" ], "offsets": [ [ 149, 157 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR006011" } ] }, { "id": "1.0alpha7.train.268.ent1_0", "type": "chemical", "text": [ "Ca2+" ], "offsets": [ [ 105, 109 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5460341" } ] }, { "id": "1.0alpha7.train.268.ent2_0", "type": "protein-domain", "text": [ "C2A domain" ], "offsets": [ [ 135, 145 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.268.coref0", "entity_ids": [ "1.0alpha7.train.268.ent0_0" ] }, { "id": "1.0alpha7.train.268.coref1", "entity_ids": [ "1.0alpha7.train.268.ent1_0" ] }, { "id": "1.0alpha7.train.268.coref2", "entity_ids": [ "1.0alpha7.train.268.ent2_0" ] } ]

[ { "id": "1.0alpha7.train.268.rel0s1.0alpha7.train.268.ent0_0.o1.0alpha7.train.268.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.268.ent0_0", "arg2_id": "1.0alpha7.train.268.ent2_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.269.sent", "type": "sentence", "text": [ "In this report, we show that AlF-C1 and AlF-C2 bind directly to Orc1, a subunit of ORC, and discuss that in mammalian cells, sequence-specific DNA-binding proteins might be involved in recruiting ORC to regulate replication initiation and/or transcription repression." ], "offsets": [ [ 0, 267 ] ] } ]

[ { "id": "1.0alpha7.train.269.ent0_0", "type": "protein", "text": [ "AlF-C2" ], "offsets": [ [ 40, 46 ] ], "normalized": [] }, { "id": "1.0alpha7.train.269.ent1_0", "type": "protein", "text": [ "AlF-C1" ], "offsets": [ [ 29, 35 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "O88311" } ] }, { "id": "1.0alpha7.train.269.ent2_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 143, 146 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.269.ent3_0", "type": "protein-complex", "text": [ "ORC" ], "offsets": [ [ 83, 86 ] ], "normalized": [] }, { "id": "1.0alpha7.train.269.ent4_1", "type": "protein-complex", "text": [ "ORC" ], "offsets": [ [ 196, 199 ] ], "normalized": [] }, { "id": "1.0alpha7.train.269.ent5_0", "type": "protein", "text": [ "Orc1" ], "offsets": [ [ 64, 68 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4998" }, { "db_name": "hgnc", "db_id": "ORC1" }, { "db_name": "uniprot", "db_id": "Q13415" } ] } ]

[]

[ { "id": "1.0alpha7.train.269.coref0", "entity_ids": [ "1.0alpha7.train.269.ent0_0" ] }, { "id": "1.0alpha7.train.269.coref1", "entity_ids": [ "1.0alpha7.train.269.ent1_0" ] }, { "id": "1.0alpha7.train.269.coref2", "entity_ids": [ "1.0alpha7.train.269.ent2_0" ] }, { "id": "1.0alpha7.train.269.coref3", "entity_ids": [ "1.0alpha7.train.269.ent3_0", "1.0alpha7.train.269.ent4_1" ] }, { "id": "1.0alpha7.train.269.coref4", "entity_ids": [ "1.0alpha7.train.269.ent5_0" ] } ]

[ { "id": "1.0alpha7.train.269.rel0s1.0alpha7.train.269.ent1_0.o1.0alpha7.train.269.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.269.ent1_0", "arg2_id": "1.0alpha7.train.269.ent5_0", "normalized": [] }, { "id": "1.0alpha7.train.269.rel1s1.0alpha7.train.269.ent0_0.o1.0alpha7.train.269.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.269.ent0_0", "arg2_id": "1.0alpha7.train.269.ent5_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.270.sent", "type": "sentence", "text": [ "It has been shown that APC makes a complex with beta-catenin and that the phosphorylation of APC by GSK-3beta increases the binding of APC to beta-catenin ( 37)." ], "offsets": [ [ 0, 161 ] ] } ]

[ { "id": "1.0alpha7.train.270.ent0_0", "type": "protein", "text": [ "APC" ], "offsets": [ [ 23, 26 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "324" }, { "db_name": "hgnc", "db_id": "APC" } ] }, { "id": "1.0alpha7.train.270.ent1_1", "type": "protein", "text": [ "APC" ], "offsets": [ [ 93, 96 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "324" }, { "db_name": "hgnc", "db_id": "APC" } ] }, { "id": "1.0alpha7.train.270.ent2_2", "type": "protein", "text": [ "APC" ], "offsets": [ [ 135, 138 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "324" }, { "db_name": "hgnc", "db_id": "APC" } ] }, { "id": "1.0alpha7.train.270.ent3_0", "type": "protein", "text": [ "GSK-3beta" ], "offsets": [ [ 100, 109 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2932" }, { "db_name": "hgnc", "db_id": "GSK3B" }, { "db_name": "uniprot", "db_id": "P49841" } ] }, { "id": "1.0alpha7.train.270.ent4_0", "type": "protein", "text": [ "beta-catenin" ], "offsets": [ [ 48, 60 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1499" }, { "db_name": "hgnc", "db_id": "CTNNB1" }, { "db_name": "uniprot", "db_id": "P35222" } ] }, { "id": "1.0alpha7.train.270.ent5_1", "type": "protein", "text": [ "beta-catenin" ], "offsets": [ [ 142, 154 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1499" }, { "db_name": "hgnc", "db_id": "CTNNB1" }, { "db_name": "uniprot", "db_id": "P35222" } ] } ]

[]

[ { "id": "1.0alpha7.train.270.coref0", "entity_ids": [ "1.0alpha7.train.270.ent0_0", "1.0alpha7.train.270.ent1_1", "1.0alpha7.train.270.ent2_2" ] }, { "id": "1.0alpha7.train.270.coref1", "entity_ids": [ "1.0alpha7.train.270.ent3_0" ] }, { "id": "1.0alpha7.train.270.coref2", "entity_ids": [ "1.0alpha7.train.270.ent4_0", "1.0alpha7.train.270.ent5_1" ] } ]

[ { "id": "1.0alpha7.train.270.rel0s1.0alpha7.train.270.ent0_0.o1.0alpha7.train.270.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.270.ent0_0", "arg2_id": "1.0alpha7.train.270.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.270.rel0s1.0alpha7.train.270.ent0_0.o1.0alpha7.train.270.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.270.ent0_0", "arg2_id": "1.0alpha7.train.270.ent5_1", "normalized": [] }, { "id": "1.0alpha7.train.270.rel0s1.0alpha7.train.270.ent1_1.o1.0alpha7.train.270.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.270.ent1_1", "arg2_id": "1.0alpha7.train.270.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.270.rel0s1.0alpha7.train.270.ent1_1.o1.0alpha7.train.270.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.270.ent1_1", "arg2_id": "1.0alpha7.train.270.ent5_1", "normalized": [] }, { "id": "1.0alpha7.train.270.rel0s1.0alpha7.train.270.ent2_2.o1.0alpha7.train.270.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.270.ent2_2", "arg2_id": "1.0alpha7.train.270.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.270.rel0s1.0alpha7.train.270.ent2_2.o1.0alpha7.train.270.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.270.ent2_2", "arg2_id": "1.0alpha7.train.270.ent5_1", "normalized": [] } ]

[ { "id": "1.0alpha7.train.271.sent", "type": "sentence", "text": [ "Interestingly, dTAFII110 also bound GST-IIAτ more abundantly than it bound to GST-αβ (Fig.4 C, lane 4)." ], "offsets": [ [ 0, 103 ] ] } ]

[ { "id": "1.0alpha7.train.271.ent0_0", "type": "protein", "text": [ "dTAFII110" ], "offsets": [ [ 15, 24 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "B7Z060" } ] }, { "id": "1.0alpha7.train.271.ent1_0", "type": "protein", "text": [ "αβ" ], "offsets": [ [ 82, 84 ] ], "normalized": [] }, { "id": "1.0alpha7.train.271.ent2_0", "type": "experiment-tag", "text": [ "GST" ], "offsets": [ [ 36, 39 ] ], "normalized": [ { "db_name": "intenz", "db_id": "2.5.1.18" } ] }, { "id": "1.0alpha7.train.271.ent3_1", "type": "experiment-tag", "text": [ "GST" ], "offsets": [ [ 78, 81 ] ], "normalized": [ { "db_name": "intenz", "db_id": "2.5.1.18" } ] }, { "id": "1.0alpha7.train.271.ent4_0", "type": "fusion-protein", "text": [ "GST-αβ" ], "offsets": [ [ 78, 84 ] ], "normalized": [] }, { "id": "1.0alpha7.train.271.ent5_0", "type": "fusion-protein", "text": [ "GST-IIAτ" ], "offsets": [ [ 36, 44 ] ], "normalized": [] }, { "id": "1.0alpha7.train.271.ent6_0", "type": "protein", "text": [ "IIAτ" ], "offsets": [ [ 40, 44 ] ], "normalized": [] } ]

[]

[ { "id": "1.0alpha7.train.271.coref0", "entity_ids": [ "1.0alpha7.train.271.ent0_0" ] }, { "id": "1.0alpha7.train.271.coref1", "entity_ids": [ "1.0alpha7.train.271.ent1_0" ] }, { "id": "1.0alpha7.train.271.coref2", "entity_ids": [ "1.0alpha7.train.271.ent2_0", "1.0alpha7.train.271.ent3_1" ] }, { "id": "1.0alpha7.train.271.coref3", "entity_ids": [ "1.0alpha7.train.271.ent4_0" ] }, { "id": "1.0alpha7.train.271.coref4", "entity_ids": [ "1.0alpha7.train.271.ent5_0" ] }, { "id": "1.0alpha7.train.271.coref5", "entity_ids": [ "1.0alpha7.train.271.ent6_0" ] } ]

[ { "id": "1.0alpha7.train.271.rel0s1.0alpha7.train.271.ent0_0.o1.0alpha7.train.271.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.271.ent0_0", "arg2_id": "1.0alpha7.train.271.ent5_0", "normalized": [] }, { "id": "1.0alpha7.train.271.rel1s1.0alpha7.train.271.ent0_0.o1.0alpha7.train.271.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.271.ent0_0", "arg2_id": "1.0alpha7.train.271.ent4_0", "normalized": [] } ]

[ { "id": "1.0alpha7.train.272.sent", "type": "sentence", "text": [ "Hes6 binds to an Enhancer of Split E box and mediates transcriptional repression" ], "offsets": [ [ 0, 80 ] ] } ]

[ { "id": "1.0alpha7.train.272.ent0_0", "type": "DNA", "text": [ "Split E box" ], "offsets": [ [ 29, 40 ] ], "normalized": [] }, { "id": "1.0alpha7.train.272.ent1_0", "type": "protein", "text": [ "Hes6" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "55502" }, { "db_name": "hgnc", "db_id": "HES6" }, { "db_name": "uniprot", "db_id": "B8ZZP9" } ] } ]

[]

[ { "id": "1.0alpha7.train.272.coref0", "entity_ids": [ "1.0alpha7.train.272.ent0_0" ] }, { "id": "1.0alpha7.train.272.coref1", "entity_ids": [ "1.0alpha7.train.272.ent1_0" ] } ]

[ { "id": "1.0alpha7.train.272.rel0s1.0alpha7.train.272.ent0_0.o1.0alpha7.train.272.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.272.ent0_0", "arg2_id": "1.0alpha7.train.272.ent1_0", "normalized": [] } ]