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-2649224702059183499-hardneg-9 | Sterilization (microbiology) | Most autoclaves have meters and charts that record or display information, particularly temperature and pressure as a function of time. The information is checked to ensure that the conditions required for sterilization have been met. Indicator tape is often placed on the packages of products prior to autoclaving, and some packaging incorporates indicators. The indicator changes color when exposed to steam, providing a visual confirmation. | [
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-2649224702059183499-hardneg-10 | Sterilization (microbiology) | For autoclaving, cleaning is critical. Extraneous biological matter or grime may shield organisms from steam penetration. Proper cleaning can be achieved through physical scrubbing, sonication, ultrasound, or pulsed air. | [
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-2649224702059183499-hardneg-11 | Sterilization (microbiology) | Pressure cooking and canning is analogous to autoclaving, and when performed correctly renders food sterile. | [
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-2649224702059183499-hardneg-12 | Sterilization (microbiology) | To sterilize waste materials that are chiefly composed of liquid, a purpose-built effluent decontamination system can be utilized. These devices can function using a variety of sterilants, although using heat via steam is most common. | [
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-2649224702059183499-hardneg-13 | Sterilization (microbiology) | The standard setting for a hot air oven is at least two hours at . A rapid method heats air to for 6 minutes for unwrapped objects and 12 minutes for wrapped objects. Dry heat has the advantage that it can be used on powders and other heat-stable items that are adversely affected by steam (e.g. it does not cause rusting of steel objects). | [
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-2649224702059183499-hardneg-14 | Sterilization (microbiology) | Incineration is a waste treatment process that involves the combustion of organic substances contained in waste materials. This method also burns any organism to ash. It is used to sterilize medical and other biohazardous waste before it is discarded with non-hazardous waste. Bacteria incinerators are mini furnaces that incinerate and kill off any microorganisms that may be on an inoculating loop or wire. | [
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-2649224702059183499-hardneg-15 | Sterilization (microbiology) | The most common EO processing method is the gas chamber method. To benefit from economies of scale, EO has traditionally been delivered by filling a large chamber with a combination of gaseous EO either as pure EO, or with other gases used as diluents; diluents include chlorofluorocarbons (CFCs), hydrochlorofluorocarbons (HCFCs), and carbon dioxide. | [
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-2649224702059183499-hardneg-16 | Sterilization (microbiology) | It is important to adhere to patient and healthcare personnel government specified limits of EO residues in and/or on processed products, operator exposure after processing, during storage and handling of EO gas cylinders, and environmental emissions produced when using EO. | [
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-2649224702059183499-hardneg-17 | Sterilization (microbiology) | Eniware, LLC has developed a portable, power-free sterilizer that uses no electricity, heat or water. The 25 liter unit makes sterilization of surgical instruments possible for austere forward surgical teams, in health centers throughout the world with intermittent or no electricity and in disaster relief and humanitarian crisis situations. The four hour cycle uses a single use gas generation ampoule and a disposable scrubber to remove nitrogen dioxide gas. | [
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-2649224702059183499-hardneg-18 | Sterilization (microbiology) | Ozone is used in industrial settings to sterilize water and air, as well as a disinfectant for surfaces. It has the benefit of being able to oxidize most organic matter. On the other hand, it is a toxic and unstable gas that must be produced on-site, so it is not practical to use in many settings. | [
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-2649224702059183499-hardneg-19 | Sterilization (microbiology) | Vaporized hydrogen peroxide (VHP) is used to sterilize large enclosed and sealed areas, such as entire rooms and aircraft interiors. | [
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-2649224702059183499-hardneg-20 | Sterilization (microbiology) | Sterilization can be achieved using electromagnetic radiation, such as ultraviolet light, X-rays and gamma rays, or irradiation by subatomic particles such as by electron beams. Electromagnetic or particulate radiation can be energetic enough to ionize atoms or molecules (ionizing radiation), or less energetic (non-ionizing radiation). | [
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-2649224702059183499-hardneg-21 | Sterilization (microbiology) | The safety of irradiation facilities is regulated by the International Atomic Energy Agency of the United Nations and monitored by the different national Nuclear Regulatory Commissions (NRC). The radiation exposure accidents that have occurred in the past are documented by the agency and thoroughly analyzed to determine the cause and improvement potential. Such improvements are then mandated to retrofit existing facilities and future design. | [
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-2649224702059183499-hardneg-22 | Sterilization (microbiology) | Gamma radiation is very penetrating, and is commonly used for sterilization of disposable medical equipment, such as syringes, needles, cannulas and IV sets, and food. It is emitted by a radioisotope, usually cobalt-60 (60Co) or caesium-137 (137Cs), which have photon energies of up to 1.3 and 0.66 MeV, respectively. | [
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-2649224702059183499-hardneg-23 | Sterilization (microbiology) | Electron beam processing is also commonly used for sterilization. Electron beams use an on-off technology and provide a much higher dosing rate than gamma or X-rays. Due to the higher dose rate, less exposure time is needed and thereby any potential degradation to polymers is reduced. Because electrons carry a charge, electron beams are less penetrating than both gamma and X-rays. Facilities rely on substantial concrete shields to protect workers and the environment from radiation exposure. | [
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-2649224702059183499-hardneg-24 | Sterilization (microbiology) | Irradiation with X-rays, gamma rays, or electrons does not make materials radioactive, because the energy used is too low. Generally an energy of at least 10 MeV is needed to induce radioactivity in a material. Neutrons and very high-energy particles can make materials radioactive, but have good penetration, whereas lower energy particles (other than neutrons) cannot make materials radioactive, but have poorer penetration. | [
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-2649224702059183499-hardneg-25 | Sterilization (microbiology) | Irradiation is used by the United States Postal Service to sterilize mail in the Washington, D.C. area. Some foods (e.g. spices and ground meats) are sterilized by irradiation. | [
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-8465478685812605400-hardneg-1 | Japanese writing system | To a lesser extent, modern written Japanese also uses initialisms from the Latin alphabet, for example in terms such as "BC/AD", "a.m./p.m.", "FBI", and "CD". Romanized Japanese is most frequently used by foreign students of Japanese who have not yet mastered kana, and by native speakers for computer input. | [
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-8465478685812605400-hardneg-3 | Japanese writing system | It is known from archaeological evidence that the first contacts that the Japanese had with Chinese writing took place in the 1st century AD, during the late Yayoi period. However, the Japanese people of that era probably had little to no comprehension of the script, and they would remain relatively illiterate until the 5th century AD, already in the Kofun period, when writing in Japan became more widespread. | [
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-8465478685812605400-hardneg-5 | Japanese writing system | Some Japanese words are written with different kanji depending on the specific usage of the word—for instance, the word "naosu" (to fix, or to cure) is written when it refers to curing a person, and when it refers to fixing an object. | [
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-8465478685812605400-hardneg-6 | Japanese writing system | Unusual or nonstandard kanji readings may be glossed using furigana. Kanji compounds are sometimes given arbitrary readings for stylistic purposes. For example, in Natsume Sōseki's short story "The Fifth Night", the author uses for "tsunagatte", the gerundive "-te" form of the verb "tsunagaru" ("to connect"), which would usually be written as or . The word , meaning "connection", is normally pronounced "setsuzoku". | [
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-8465478685812605400-hardneg-7 | Japanese writing system | emerged as a manual simplification via cursive script of the most phonetically widespread kanji among those who could read and write during the Heian period (794-1185). The main creators of the current hiragana were ladies of the Japanese imperial court, that used the script in the writing of personal communications and literature. | [
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-8465478685812605400-hardneg-8 | Japanese writing system | Some lexical items that are normally written using kanji have become grammaticalized in certain contexts, where they are instead written in hiragana. For example, the root of the verb ("miru", "see") is normally written with the kanji for the "mi" portion. However, when used as a supplementary verb as in 試してみる ("tameshite miru") meaning "to try out", the whole verb is typically written in hiragana as , as we see also in ("tabete miru", "try to eat [it] and see"). | [
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-8465478685812605400-hardneg-9 | Japanese writing system | emerged around the 9th century, in the Heian period, when Buddhist monks created a syllabary derived from Chinese characters to simplify their reading, using portions of the characters as a kind of shorthand. The origin of the alphabet is attributed to the monk Kūkai. | [
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-8465478685812605400-hardneg-11 | Japanese writing system | The first contact of the Japanese with the Latin alphabet occurred in the 16th century, during the Muromachi period, when they had contact with Portuguese navigators, the first European people to visit the Japanese islands. The earliest Japanese romanization system was based on Portuguese orthography. It was developed around 1548 by a Japanese Catholic named Anjirō. | [
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-8465478685812605400-hardneg-13 | Japanese writing system | "Jukujikun" refers to instances in which words are written using "kanji" that reflect the meaning of the word though the pronunciation of the word is entirely unrelated to the usual pronunciations of the constituent "kanji". Conversely, "ateji" refers to the employment of "kanji" that appear solely to represent the sound of the compound word but are, conceptually, utterly unrelated to the signification of the word. | [
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-8465478685812605400-hardneg-17 | Japanese writing system | Although rare, there are some words that use all three scripts in the same word. An example of this is the term くノ一 ("rōmaji": "kunoichi"), which uses a hiragana, a katakana, and a kanji character, in that order. It is said that if all three characters are put in the same kanji "square", they all combine to create the kanji (woman/female). Another example is (rōmaji: "keshigomu") which means "eraser", and uses a kanji, a hiragana, and two katakana characters, in that order. | [
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] |
-8465478685812605400-hardneg-18 | Japanese writing system | A statistical analysis of a corpus of the Japanese newspaper "Asahi Shimbun" from the year 1993 (around 56.6 million tokens) revealed: | [
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-8465478685812605400-hardneg-19 | Japanese writing system | Collation (word ordering) in Japanese is based on the kana, which express the pronunciation of the words, rather than the kanji. The kana may be ordered using two common orderings, the prevalent "gojūon" (fifty-sound) ordering, or the old-fashioned "iroha" ordering. Kanji dictionaries are usually collated using the radical system, though other systems, such as SKIP, also exist. | [
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-8465478685812605400-hardneg-23 | Japanese writing system | Words in potentially unfamiliar foreign compounds, normally transliterated in katakana, may be separated by a punctuation mark called a "nakaguro" (, "middle dot") to aid Japanese readers. For example, (Bill Gates). This punctuation is also occasionally used to separate native Japanese words, especially in concatenations of kanji characters where there might otherwise be confusion or ambiguity about interpretation, and especially for the full names of people. | [
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-8465478685812605400-hardneg-24 | Japanese writing system | Japan's first encounters with Chinese characters may have come as early as the 1st century AD with the King of Na gold seal, said to have been given by Emperor Guangwu of Han in AD 57 to a Japanese emissary. However, it is unlikely that the Japanese became literate in Chinese writing any earlier than the 4th century AD. | [
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-8465478685812605400-hardneg-25 | Japanese writing system | Initially Chinese characters were not used for writing Japanese, as literacy meant fluency in Classical Chinese, not the vernacular. Eventually a system called developed, which, along with kanji and something very similar to Chinese grammar, employed diacritics to hint at the Japanese translation. The earliest written history of Japan, the , compiled sometime before 712, was written in kanbun. Even today Japanese high schools and some junior high schools teach kanbun as part of the curriculum. | [
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-8465478685812605400-hardneg-26 | Japanese writing system | Some linguists have compared the Japanese borrowing of Chinese-derived vocabulary as akin to the influx of Romance vocabulary into English during the Norman conquest of England. Like English, Japanese has many synonyms of differing origin, with words from both Chinese and native Japanese. Sino-Japanese is often considered more formal or literary, just as latinate words in English often mark a higher register. | [
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-8465478685812605400-hardneg-27 | Japanese writing system | In 1900, the Education Ministry introduced three reforms aimed at improving the education in Japanese writing: | [
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-8465478685812605400-hardneg-29 | Japanese writing system | The period immediately following World War II saw a rapid and significant reform of the writing system. This was in part due to influence of the Occupation authorities, but to a significant extent was due to the removal of traditionalists from control of the educational system, which meant that previously stalled revisions could proceed. The major reforms were: | [
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-8465478685812605400-hardneg-30 | Japanese writing system | At one stage, an advisor in the Occupation administration proposed a wholesale conversion to rōmaji; however, it was not endorsed by other specialists and did not proceed. | [
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-8465478685812605400-hardneg-31 | Japanese writing system | In addition, the practice of writing horizontally in a right-to-left direction was generally replaced by left-to-right writing. The right-to-left order was considered a special case of vertical writing, with columns one character high, rather than horizontal writing per se; it was used for single lines of text on signs, etc. (e.g., the station sign at Tokyo reads ). | [
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-8465478685812605400-hardneg-32 | Japanese writing system | The post-war reforms have mostly survived, although some of the restrictions have been relaxed. The replacement of the "tōyō kanji" in 1981 with the 1,945 —a modification of the "tōyō kanji"—was accompanied by a change from "restriction" to "recommendation", and in general the educational authorities have become less active in further script reform. | [
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-4736658335579254930-hardneg-0 | History of diabetes | The Ebers Papyrus is among the oldest and most important medical papyri of Ancient Egypt. Written 1550 BC, it was likely copied from a series of much earlier texts, and contains a passage from the First Dynasty (c. 3400 BC). The document is named after Georg Ebers, who purchased the document in 1872 in the city of Luxor, the site of Thebes (known to Ancient Egyptians as Waset). Thebes was the most venerated city of Ancient Egypt in its heyday during the Middle Kingdom and New Kingdom. | [
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-4736658335579254930-hardneg-1 | History of diabetes | The Ebers Papyrus is thought to contain the first known medical reference to diabetes, by the phrase: "...to eliminate urine which is too "asha"". The crucial word "asha" can mean both "plentiful" and "often". It is unclear whether the condition described was excessive urine (polyuria), which may have been symptomatic of diabetes, or increased frequency of urine, very often due to urinary tract infection. | [
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-4736658335579254930-hardneg-2 | History of diabetes | The following mixture was prescribed for treatment: "A measuring glass filled with Water from the Bird pond, Elderberry, Fibres of the asit plant, Fresh Milk, Beer-Swill, Flower of the Cucumber, and Green Dates". Urinary troubles in the adult were also corrected with "rectal injections of olive oil, honey, sweet beer, sea salt, and seeds of the wonderfruit". | [
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-4736658335579254930-hardneg-3 | History of diabetes | Ayurveda is a Hindu system of medicine with historic roots in the Indian subcontinent. Some of its conceptual origins trace back to the Indus Valley civilisation. It developed significantly through the Vedic period. | [
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-4736658335579254930-hardneg-4 | History of diabetes | Ayurvedic texts provided dietary prescriptions for the condition. They constitute the earliest known references to the presence of sugar in the urine (glycosuria) and to dietary remedies, at least a thousand years before modern European descriptions began to more comprehensively conceptualize the disease. Sushruta and Charaka also identified the two types of diabetes mellitus, later dubbed Type I and Type II diabetes. | [
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-4736658335579254930-hardneg-5 | History of diabetes | Reviews of diabetology history in Traditional Chinese medicine have classified the diagnosis and treatment of "" () into four periods, summarized below. Classic texts provided a typology of the condition and outlined various recommendations on diagnosis, development, treatment, and prevention. Knowledge of wasting-thirst was integrated with knowledge of diabetes during the Qing dynasty. | [
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-4736658335579254930-hardneg-6 | History of diabetes | (), or "The Yellow Emperor's Classic of Internal Medicine", is a fundamental ancient text in Chinese medicine and a major book of Daoist philosophy and lifestyle. It is generally dated to the late Warring States period (475–221 BC) and the Western Han dynasty (206 BC-8 AD). | [
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-4736658335579254930-hardneg-7 | History of diabetes | The text named the condition "" (; "wasting-thirst") and elaborated on it through 25 clauses. It recorded such symptoms as "three increases [excess] and one decrease [loss]": excessive thirst (polydypsia), excessive hunger (polyphagia), excessive urine (polyuria), and weight loss. Three sub-phases of "xiāo kě" were given, characterized by their dominant symptoms. These roughly correspond to the progressive stages of diabetes in modern-day Western medicine. | [
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-4736658335579254930-hardneg-8 | History of diabetes | (), or , is the first Chinese monograph on diseases by Zhang Zhongjing. The original work is lost, but most of its contents are preserved in two extant works called "Shānghán Lùn" (; "The Treatise on Cold Damage") and "Jīnguì Yàolüè" (; "Essential Prescriptions from the Golden Chamber"). The first work primarily addresses externally triggered conditions while the latter work describes internally generated conditions. | [
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-4736658335579254930-hardneg-9 | History of diabetes | Sun Simiao (581–682 AD) further developed approaches to treatment, prevention, regulation, nursing, and convalescence. The formulae for wasting-thirst grew from one in "The Yellow Emperor's Classic of Internal Medicine", to nine in Zhang Zhongjing's works, to 73 in Sun Simiao's. The selection of herbs grew from one ("Eupatorium fortunei"), to dozens used by Zhang, to over one hundred used by Sun. | [
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-4736658335579254930-hardneg-10 | History of diabetes | During the Ming (1368–1644) and Qing (1644–1912) dynasties, medical discoveries slowed but practitioners achieved significant knowledge integration across cultures. Over one hundred comprehensive medical monographs were cultivated, many synthesizing developments in the study of wasting-thirst and of diabetes. | [
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-4736658335579254930-hardneg-11 | History of diabetes | Zhang Xichun (1860–1933), a renowned integrator of medical knowledge, produced (among other works) (; "The Integration of Traditional Chinese and Western Medicine"). In a dedicated chapter named " therapies", he discussed the following aspects synthesizing wasting-thirst and diabetes: nomenclature, theories (pathologies), primary formulae, medications (herbology and pharmacology), nursing (diet and maintenance), medical cases, and integrated analysis (protein and essence; qi and fluids). | [
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-4736658335579254930-hardneg-12 | History of diabetes | Yu Yunxiu (1879–1954), a Japanese-educated practitioner of Western medicine aligned with the modernizer camp of the Chinese Ministry of Health, attempted to forbid the practice of Chinese medicine in 1929. In 1939, he wrote on the rough equivalence of wasting-thirst and diabetes. | [
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-4736658335579254930-hardneg-13 | History of diabetes | Greco-Roman accounts of what we now know as diabetes primarily describe excessive urination (polyuria). There is no known account of sweetness in early Greco-Roman concepts of the disease. Given the lasting legacy of classical medicine, these descriptions remained highly influential into the Middle Ages in Europe. | [
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-4736658335579254930-hardneg-14 | History of diabetes | It is assumed that the Hippocratic Corpus bears no direct mention of what we now know as diabetes. However, a number of indirect statements referring to excessive and "watery urine" suggest that Hippocratic writers may have been familiar with the condition. | [
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-4736658335579254930-hardneg-15 | History of diabetes | In his classic description of diabetes, Aretaeus of Cappadocia ("fl." early 2nd century AD) noted the excessive amount of urine that passed through the kidney. He also noted its rarity ("Diabetes is a wonderful affection, not very frequent among men..."). He described the disease as "a melting down of the flesh and limbs into urine" and attributed it to the bladder and kidneys, commenting that "life (with diabetes) is short, disgusting and painful." | [
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-4736658335579254930-hardneg-16 | History of diabetes | Aretaeus's contemporary Galen (129-200 AD) stressed that diabetes was a disease of the kidneys and affirmed its rarity, having observed it "only twice" at the time he wrote "On the affected parts". | [
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-4736658335579254930-hardneg-17 | History of diabetes | Aretaeus and the others authors under discussion did not differentiate between "diabetes mellitus" and "diabetes insipidus". It is assumed that they were referring to diabetes mellitus, although Swedish physician F. Henschen has suggested that Aretaeus and Galen may have instead been referring to diabetes insipidus. For all practical purposes, however, diabetes insipidus remained unrecognized well into the 17th century. | [
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-4736658335579254930-hardneg-18 | History of diabetes | Aulus Cornelius Celsus ("fl." 30 BC-50 AD), who interpreted Greek works in Latin, provided an early clinical description of diabetes in his eight-volume work titled "De Medicina". He wrote that "urine exceeds in quantity the fluid taken even if it is passed painlessly." This concept of an imbalance between the ingested and excreted amounts of fluid was repeated by many authors into the Middle Ages. | [
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-4736658335579254930-hardneg-19 | History of diabetes | Rufus of Ephesus ("fl". 98–117 AD), a physician famous for his work on the variations of the pulse, described the symptoms of diabetes as "incessant thirst" and immediate urination after drinking, which he called "urinary diarrhea". | [
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-4736658335579254930-hardneg-20 | History of diabetes | The Byzantine Empire was a continuation of the Roman Empire in its eastern provinces after the Fall of the Western Roman Empire. The capital was Constantinople (modern Istanbul, former Byzantium). It was conquered by the Ottomans in 1453. | [
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-4736658335579254930-hardneg-21 | History of diabetes | Physician Oribasius (c. 320–403), personal physician of the emperor and philosopher Julian, compiled all known ancient medical texts of his time by theme into medical encyclopedia. He quotes Galen and Rufus on diabetes, considering it to be a polyuric disease of the kidneys. Various descriptive names are given for the condition, including: chamber-pot dropsy, diarrhea of the urine (diarrhea urinosa), and the thirsty disease. | [
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-4736658335579254930-hardneg-22 | History of diabetes | These descriptions, along with a number of other names for the condition ("liuria", "extreme thirst or dipsacus"), were echoed by later Byzantine writers in key encyclopedic texts. | [
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-4736658335579254930-hardneg-23 | History of diabetes | During the Islamic Golden Age under the Abbasid Caliphate, prominent Muslim physicians preserved, systematized and developed ancient medical knowledge from across the Eurasian continent. They synthesized concepts from classical antiquity ("see:" "Ancient Greece, Ancient Rome"), Persia, Ayurveda, and China. This work laid the foundations for later advances in medieval European medicine as European physicians came into contact with Islamic authors through the Renaissance of the 12th century. | [
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-4736658335579254930-hardneg-24 | History of diabetes | Rhazes (c. 865–925), or Muhammad ibn Zakariya al-Razi, included writings about diabetes in the more than 230 books he produced in his lifetime. | [
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-4736658335579254930-hardneg-25 | History of diabetes | It has been noted that references to diabetes expanded in the medical texts of this period. Eknoyan and Nagy (2005) speculate that this indicates the increasing prevalence of the disease. Other interpretations are also possible, including that the increasing references are the result of more systematic knowledge sharing practices. | [
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-4736658335579254930-hardneg-26 | History of diabetes | Maimonides (c. 1135–1204), a renowned philosopher and polymath of the era in both the Jewish and Islamic worlds, claimed to have seen more than 20 cases (in contrast to Galen's two cases). | [
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-4736658335579254930-hardneg-27 | History of diabetes | Abd al-Latif al-Baghdadi (1162–1231), also a philosopher and polymath, produced a treatise dedicated to diabetes ("On Diabetes", Fols. 140v-149r). | [
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-4736658335579254930-hardneg-28 | History of diabetes | In the 16th century, Paracelsus (1493–1541) described diabetes as a constitutional disease that "irritates the kidneys" and provokes excessive urination. He reported that evaporating urine from a diabetic patient left an excessive residue, which he called "salts". It has, however, been noted that he advised tasting the urine for sweetness in other contexts. | [
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-4736658335579254930-hardneg-29 | History of diabetes | The presence of sugar in the urine (glycosuria) and in the blood (hyperglycemia) was demonstrated through the work of a number of physicians in the late 18th century, including Robert Wyatt (1774) and Matthew Dobson (1776). | [
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-4736658335579254930-hardneg-30 | History of diabetes | Historically, various notions of present-day "diabetes" have described some general mix of excessive urine (polyuria), excessive thirst (polydipsia), and weight loss (see: "History of diabetes#Early accounts"). Over the past few centuries, these symptoms have been linked to updated understandings of how the disease works, and how it manifests differently across cases. This section outlines these developments as various diabetic conditions have become better understood. | [
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-4736658335579254930-hardneg-31 | History of diabetes | Today, the term "diabetes" most commonly refers to "diabetes mellitus. Diabetes mellitus" is itself an umbrella term for a number of different diseases involving problems processing sugars that have been consumed (glucose metabolism). Historically, this is the "diabetes" which has been associated with sugary urine (glycosuria). | [
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-4736658335579254930-hardneg-32 | History of diabetes | In 1683, a surgical experiment by Johann Conrad Brunner almost led to a medical breakthrough. He excised the pancreas of a neighbour's hunting dog, causing polyuria and polydipsia. Brunner very clearly described these classic symptoms in pancreatectomized dogs, but made no association with diabetes. | [
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-4736658335579254930-hardneg-33 | History of diabetes | The endocrine role of the pancreas in metabolism, and indeed the existence of insulin, was further clarified between 1921 and 1922 when a group of researchers in Toronto, including Frederick Grant Banting, Charles Herbert Best, J.J.R. MacLeod, and James Collip, were able to isolate and purify the extract. | [
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-4736658335579254930-hardneg-34 | History of diabetes | The terms type 1 and 2 were for some time forgotten. In 1976, they were revived and popularized by Andrew Cudworth after he discovered the link between type 1 diabetes and a specific genetic marker. | [
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-4736658335579254930-hardneg-35 | History of diabetes | In 1912, Alfred Eric Frank, then working on diabetes mellitus in the department of Oskar Minkowski in Breslau, reported a specific link to the pituitary gland upon observing a case of a man who had survived after shooting himself in the temple. Morris Simmonds drew the same connection in 1913. Thereafter, numerous reports documented cases of diabetes insipidus associated with pituitary lesions, steadily accumulating evidence favouring the hypothesized connection. | [
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-4736658335579254930-hardneg-36 | History of diabetes | Gestational diabetes insipidus has also been identified as a rare variety of disease that manifests in the third trimester of pregnancy and the early postpartum period. | [
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-4736658335579254930-hardneg-37 | History of diabetes | Among others, Frederick Madison Allen's "starvation diet" was notoriously spartan, but was shown to extend life expectancy. Elizabeth Hughes Gossett, later among the first people to be treated with insulin, was among Allen's patients. | [
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-4736658335579254930-hardneg-38 | History of diabetes | A diabetes clinic was established at Toronto General Hospital that summer to increase capacity for treatment by Banting and collaborating physicians. The non-commercial Connaught Laboratories collaborated with researchers to scale production. Once limits were reached, Toronto contracted with Eli Lilly and Company beginning May 1922 with some caution regarding the commercial nature of the firm (see: "Insulin#History of study#Patent"). | [
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-4736658335579254930-hardneg-39 | History of diabetes | In 2005, a new drug to treat type 2 diabetes, derived from the Gila monster was approved by the Food and Drug Administration. The venom of the lizard contains exendin 4, which triggers one of the insulin-releasing pathways. | [
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-4736658335579254930-hardneg-40 | History of diabetes | In 1928, Oliver Kamm and his colleagues posited two active principles in the pituitary extract: one with antidiuretic and pressor properties (vasopressin), and another with uterotonic properties (oxytocin). In a series of landmark achievements between 1947 and 1954 which culminated in a Nobel Prize in Chemistry (1955), Vincent du Vigneaud isolated, sequenced, and synthesized oxytocin and vasopressin. Today, synthesized and modified vasopressin is used to treat the condition. | [
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4372363774274869182-hardneg-0 | Australia | The indigenous population declined for 150 years following settlement, mainly due to infectious disease. Thousands more died as a result of frontier conflict with settlers. | [
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4372363774274869182-hardneg-1 | Australia | In 1823, a Legislative Council nominated by the governor of New South Wales was established, together with a new Supreme Court, thus limiting the powers of colonial governors. Between 1855 and 1890, the six colonies individually gained responsible government, thus becoming elective democracies managing most of their own affairs while remaining part of the British Empire. The Colonial Office in London retained control of some matters, notably foreign affairs and defence. | [
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4372363774274869182-hardneg-2 | Australia | In the mid-19th century, explorers such as Burke and Wills went further inland to determine its agricultural potential and answer scientific questions. A series of gold rushes beginning in the early 1850s led to an influx of new migrants from China, North America and continental Europe, as well as outbreaks of bushranging and civil unrest; the latter peaked in 1854 when Ballarat miners launched the Eureka Rebellion against gold license fees. | [
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4372363774274869182-hardneg-3 | Australia | At the 2021 census, 38.9% of the population identified as having "no religion". The largest religious affiliation was Christianity at 43.9%. The largest Christian denominational affiliations were Catholicism at 20% and Anglicanism at 9.8%. The largest non-Christian religious affiliations were Islam (3.2%); Hinduism (2.7%); Buddhism (2.4%); Sikhism (0.8%); and Judaism (0.4%). | [
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8028609276279122081-hardneg-0 | Umayyad Caliphate | The Umayyad Caliphate was founded by Mu'awiya I () who became acknowledged caliph at the end of the First Fitna in 661. Mu'awiya established dynastic and hereditary rule by appointing his son Yazid I () as his successor. Following Mu'awiya's death, the Second Fitna emerged as a result of conflicts over succession, and power eventually fell into the hands of Marwan I from another branch of the clan. Greater Syria remained the Umayyads' main power base thereafter, with Damascus serving as their capital. | [
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8028609276279122081-hardneg-1 | Umayyad Caliphate | The Umayyads continued the Muslim conquests, incorporating the Transoxiana, Sindh, the Maghreb and the Iberian Peninsula (Al-Andalus) under Islamic rule. At its greatest extent, the Umayyad Caliphate covered , making it one of the largest empires in history in terms of area. | [
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