id
stringlengths
1
5
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sequence
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sequence
6616
[ "The", "GATA-1", "autoregulatory", "enhancer", "effectively", "restricts", "the", "expression", "of", "the", "LTR-driven", "proviral", "transcription", "unit", "to", "the", "erythroblastic", "progeny", "of", "both", "human", "progenitors", "and", "mouse-repopulating", "stem", "cells", "." ]
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11420
[ "We", "therefore", "investigated", "whether", "NF-kappaB/Rel", "proteins", "are", "expressed", "in", "human", "neutrophils", ",", "as", "well", "as", "their", "fate", "on", "cell", "activation", "." ]
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2912
[ "Unlike", "classical", "NFkappaB", "sites", ",", "neither", "the", "SNE", "nor", "the", "SEE", "motif", "responded", "to", "phosphatase", "inhibition", "by", "okadaic", "acid", "." ]
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18179
[ "CD4+", "macrophages", "in", "tissues", "such", "as", "lung", ",", "skin", ",", "and", "lymph", "nodes", ",", "promyelocytic", "cells", "in", "bone", "marrow", ",", "and", "peripheral", "blood", "monocytes", "serve", "as", "important", "targets", "and", "reservoirs", "for", "human", "immunodeficiency", "virus", "type", "1", "(", "HIV-1", ")", "replication", "." ]
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16261
[ "Receptor", "transcripts", "were", "4.6", "kilobases", "(", "kb", ")", ",", "and", "no", "variant", "sizes", "were", "observed", "." ]
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4389
[ "Acylation", "of", "OspA", "and", "the", "synthetic", "peptides", "was", "requisite", "for", "cell", "activation", "." ]
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11903
[ "Furthermore", "a", "dominant", "negative", "form", "of", "AML1", ",", "AML1a", ",", "totally", "suppressed", "granulocytic", "differentiation", "otherwise", "induced", "by", "granulocyte", "colony-stimulating", "factor", "when", "AML1a", "was", "overexpressed", "in", "32Dc13", "murine", "myeloid", "cells", "." ]
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13742
[ "Gel", "retardation", "assays", "with", "THP-1", "cell", "extracts", "identified", "gamma-IFN", "inducible", "DNA", "binding", "activity", "to", "three", "potential", "STATI", "DNA", "binding", "elements", "in", "the", "human", "IP-10", "promoter", "region", "from", "nucleotides", "-", "245", "to", "-", "188", "." ]
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7984
[ "Moreover", ",", "ANG", "II", "stimulated", "NF-kappaB", "activation", "in", "human", "monocytes", ",", "but", "not", "in", "lymphocytes", "from", "the", "same", "preparation", "." ]
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17202
[ "A", "powerful", "enhancer", "has", "been", "mapped", "to", "an", "18-bp", "DNA", "segment", "located", "11", "kb", "5", "'", "to", "the", "human", "epsilon-globin", "gene", "within", "the", "dominant", "control", "or", "locus-activating", "region", "." ]
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7344
[ "In", "contrast", ",", "the", "adherence", "parameter", "has", "no", "effect", "on", "the", "IL-10", "-induced", "modulation", "of", "some", "monocyte", "surface", "markers", "." ]
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6605
[ "Taken", "together", ",", "these", "data", "suggest", "that", "a", "third", "component", "is", "necessary", "for", "gene", "activation", "and", "that", "this", "third", "component", "may", "vary", "with", "cell", "type", "." ]
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17161
[ "A", "52-year-old", "male", "presented", "himself", "with", "tachycardia", "crises", "which", "appeared", "first", "during", "childhood", ",", "increased", "in", "frequency", "without", "goiter", "or", "exophthalmos", "." ]
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17546
[ "Lt-4", "reacted", "with", "all", "HTLV-I-bearing", "cell", "lines", "tested", "and", "five", "out", "of", "eight", "simian", "cell", "lines", "bearing", "STLV-I", ",", "but", "not", "with", "an", "HTLV-II-bearing", "cell", "line", "." ]
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14468
[ "Thus", ",", "p65", "and", "I", "kappa", "B", "are", "linked", "in", "an", "autoregulatory", "loop", ",", "ensuring", "that", "NF-kappa", "B", "is", "held", "in", "the", "cytoplasm", "until", "cells", "are", "specifically", "induced", "to", "translocate", "it", "to", "the", "nucleus", "." ]
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4581
[ "Activation", "of", "nuclear", "factor", "of", "activated", "T", "cells", "in", "a", "cyclosporin", "A-resistant", "pathway", "." ]
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527
[ "Adhesion", "of", "human", "monocytes", "to", "P-selectin", ",", "the", "most", "rapidly", "expressed", "endothelial", "tethering", "factor", ",", "increased", "the", "secretion", "of", "monocyte", "chemotactic", "protein-1", "(", "MCP-1", ")", "and", "tumor", "necrosis", "factor-alpha", "(", "TNF-alpha", ")", "by", "the", "leukocytes", "when", "they", "were", "stimulated", "with", "platelet-activating", "factor", "." ]
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736
[ "The", "data", "indicate", "that", "PKC-epsilon", "and", ",", "to", "a", "lesser", "extent", "PKC-alpha", "but", "not", "-zeta", ",", "can", "regulate", "the", "transcription", "factors", "AP-1", "and", "nuclear", "factor", "of", "activated", "T", "cells", "(", "NF-AT-1", ")", "." ]
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15869
[ "At", "least", "two", "21", "bp", "repeats", "were", "required", "for", "high", "levels", "of", "AP-2", "activation", "and", "mutagenesis", "of", "the", "AP-2", "consensus", "binding", "sequences", "in", "the", "21", "bp", "repeats", "eliminate", "this", "activation", "." ]
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5274
[ "Here", "we", "show", "that", "HHV-6", "upregulates", "Zebra", "gene", "transcription", "through", "a", "cyclic", "AMP-responsive", "element", "(", "CRE", ")", "located", "within", "the", "Zebra", "promoter", "(", "Zp", ")", "." ]
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1087
[ "A", "prevailing", "hypothesis", "postulates", "induction", "of", "so-called", "'", "lysis", "genes", "'", "by", "the", "activated", "receptor", "." ]
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1367
[ "When", "considered", "together", ",", "these", "data", "suggest", "that", "antioxidants", "exert", "their", "effects", "by", "impairing", "translation", "and/or", "by", "causing", "degradation", "of", "newly", "translated", "protein", "." ]
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16101
[ "The", "most", "likely", "interpretation", "of", "our", "results", "is", "that", "both", "the", "ubiquitous", "transcription", "factor", ",", "OTF-1", ",", "and", "the", "B-cell-specific", "transcription", "factor", ",", "OTF-2", ",", "can", "activate", "U2", "snRNA", "transcription", "." ]
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14814
[ "This", "increased", "processing", "and", "secretion", "correlated", "with", "the", "stimulation", "of", "IL-1", "beta", "convertase", "mRNA", "accumulation", "." ]
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11960
[ "The", "binding", "of", "the", "A6H", "mAb", "induced", "a", "costimulatory", "signal", "in", "anti-CD3", "activated", "T", "cells", "." ]
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17942
[ "An", "Epstein-Barr", "virus", "(", "EBV", ")", "-transformed", "cell", "line", "derived", "from", "her", "lymphocytes", "had", "normal", "gamma", "c", "expression", "but", "lacked", "Jak3", "protein", "and", "had", "greatly", "diminished", "Jak3", "messenger", "RNA", "." ]
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13035
[ "Low", "CD3+CD28-induced", "interleukin-2", "production", "correlates", "with", "decreased", "reactive", "oxygen", "intermediate", "formation", "in", "neonatal", "T", "cells", "." ]
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10363
[ "The", "potencies", "of", "the", "transactivation", "domains", "of", "Stat5", ",", "Stat6", ",", "and", "viral", "protein", "VP16", "were", "compared", "." ]
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2008
[ "We", "have", "analyzed", "the", "regulation", "of", "CD14", "expression", "during", "1", "alpha", ",", "25-dihydroxyvitamin", "D3", "(", "VitD3", ")", "-induced", "monocytic", "differentiation", "." ]
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11050
[ "In", "addition", ",", "our", "data", "suggests", "that", "the", "rapid", "PMA-mediated", "induction", "of", "collagenase-1", "transcription", "is", "controlled", "by", "a", "mechanism", "distinct", "from", "that", "regulating", "the", "sustained", "expression", "of", "this", "proteinase", "in", "activated", "macrophages", "." ]
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18018
[ "Overexpression", "of", "NF-IL6", "enhanced", "expression", "of", "the", "chloramphenicol", "acetyl", "transferase", "reporter", "gene", "linked", "to", "the", "PRE-I-thymidine", "kinase", "or", "the", "human", "IL-4", "promoter", "more", "than", "10-fold", "in", "Jurkat", "cells", "." ]
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7768
[ "Electrophoretic", "mobility", "shift", "assays", "showed", "that", "p50/p65/c-Rel", "and", "STAT-6", "are", "effectively", "induced", "by", "CD40L", "and", "IL-4", ",", "respectively", ",", "and", "bind", "to", "specific", "DNA", "motifs", "within", "the", "ECS", "." ]
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14985
[ "Transfection", "of", "cells", "with", "full", "length", "E2A", "cDNA", "leads", "to", "appearance", "of", "protein", "co-migrating", "with", "the", "73", "kDa", "protein", "on", "SDS", "gel", "electrophoresis", "and", "co-migrating", "with", "LEF1/BCF1", "on", "mobility", "shift", "analysis", "." ]
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8728
[ "We", "found", "that", ":", "(", "i", ")", "both", "CTCF", "mRNA", "and", "protein", "are", "down-regulated", "during", "terminal", "differentiation", "in", "most", "cell", "lines", "tested", ";", "(", "ii", ")", "CTCF", "down-regulation", "is", "retarded", "and", "less", "pronounced", "than", "that", "of", "c-myc", ";", "(", "iii", ")", "CTCF", "protein", "is", "differentially", "phosphorylated", "and", "the", "phosphorylation", "profiles", "depend", "on", "the", "differentiation", "pathway", "." ]
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5586
[ "Thrombopoietin", "also", "induced", "tyrosine", "phosphorylation", "of", "Stat3", "and", "Stat5", "in", "FDCP-2", "cells", "genetically", "engineered", "to", "constitutively", "express", "human", "c-Mpl", "." ]
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18010
[ "As", "in", "HMG1B", ",", "the", "overall", "structure", "of", "the", "Sox-4", "HMG", "box", "is", "L-shaped", "and", "is", "maintained", "by", "a", "cluster", "of", "conserved", ",", "mainly", "aromatic", "residues", "." ]
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6442
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12502
[ "These", "cytokines", "are", "therefore", "candidate", "genes", "which", "could", "contribute", "to", "the", "development", "of", "asthma", "or", "allergies", "." ]
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17727
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2761
[ "By", "using", "the", "protein", "synthesis", "inhibitor", "cycloheximide", ",", "it", "was", "shown", "that", "G", "(", "Anh", ")", "MTetra-induced", "IL-6", "mRNA", "expression", "depends", "on", "the", "synthesis", "of", "new", "protein", ",", "whereas", "G", "(", "Anh", ")", "MTetra-induced", "IL-1", "beta", "mRNA", "accumulation", "does", "not", "." ]
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17216
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14146
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4470
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2959
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5589
[ "Recent", "studies", "have", "defined", "genetic", "alterations", "commonly", "associated", "with", "transformed", "lymphocytes", "." ]
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14594
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7598
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13865
[ "We", "found", "that", "erythropoietin", "induces", "tyrosine", "phosphorylation", "of", "Jak2", ",", "STAT5A", ",", "and", "STAT5B", "." ]
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15850
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10413
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10252
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2471
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8636
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