Datasets:

siddharthtumre

/

jnlpba-split

like 0

[ "However", ",", "this", "apparent", "lack", "of", "response", "to", "the", "secosterol", "can", "be", "overcome", "by", "stimulation", "of", "B", "lymphocytes", "with", "a", "combination", "of", "these", "cellular", "activation", "signals", ",", "which", "are", "sufficient", "to", "lead", "to", "G1", "cell", "cycle", "progression", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Northern", "blot", "analyses", "performed", "on", "rat", "and", "mouse", "tissues", "have", "detected", "ubiquitously", "expressed", "Pan", "transcripts", ",", "but", "the", "abundance", ",", "distribution", ",", "and", "form", "of", "Pan", "proteins", "have", "not", "been", "clearly", "defined", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0 ]

[ "These", "insights", "in", "the", "molecular", "events", "that", "are", "involved", "in", "TCF/LEF", "function", "in", "these", "organisms", "may", "eventually", "lead", "to", "the", "understanding", "of", "the", "function", "of", "these", "HMG", "box", "proteins", "in", "lymphoid", "development" ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0 ]

[ "Induction", "of", "NF-kappa", "B", "during", "monocyte", "differentiation", "is", "associated", "with", "activation", "of", "HIV-gene", "expression", "." ]

[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Our", "results", "showed", "that", "BSAP", "plays", "a", "role", "in", "both", "IL-4", "-dependent", "induction", "and", "CD40", "-mediated", "upregulation", "of", "human", "epsilon", "germline", "transcription", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 1, 0, 0 ]

[ "We", "conclude", "that", "the", "kappaB", "element", "in", "the", "GM-CSF", "promoter", "plays", "a", "central", "role", "in", "the", "transcriptional", "activation", "of", "the", "endogenous", "GM-CSF", "gene", "." ]

[ 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "This", "difference", "in", "gene", "regulation", "suggests", "distinct", "biological", "roles", "in", "the", "control", "of", "cell", "proliferation", "for", "the", "respective", "proteins", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Relationship", "between", "Rap1", "protein", "phosphorylation", "and", "regulation", "of", "Ca2+", "transport", "in", "platelets", ":", "a", "new", "approach", "." ]

[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0 ]

[ "These", "results", "show", "that", "Spi-1/", "PU.1", "requires", "signals", "emanating", "from", "specific", "cytokine", "and", "growth", "factor", "receptors", "to", "affect", "the", "survival", ",", "proliferation", "and", "differentiation", "control", "of", "primary", "erythroblasts", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]

[ "Since", "clinical", "remission", "has", "been", "observed", "in", "a", "significant", "fraction", "of", "DLCL", "cases", ",", "these", "markers", "may", "serve", "as", "critical", "tools", "for", "sensitive", "monitoring", "of", "minimal", "residual", "disease", "and", "early", "diagnosis", "of", "relapse", "(", "Gribben", "et", "al.", "1993", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "RA", "also", "enhanced", "lyn", "mRNA", "production", "rapidly", "in", "HL-60", ",", "indicating", "that", "the", "activation", "of", "lyn", "gene", "expression", "is", "common", "in", "monocytic", "and", "granulocytic", "maturation", "of", "myeloid", "leukemia", "cells", "." ]

[ 0, 0, 0, 3, 4, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]

[ "A", "second", "messenger", "cascade", "involved", "is", "the", "inositol", "1", ",", "4", ",", "5-trisphosphate/calcium", "pathway", "which", "responds", "over", "the", "same", "rapid", "time", "course", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "ZEBRA", "activation", "region", "was", "replaced", "with", "the", "potent", "acid", "activation", "region", "from", "the", "herpes", "simplex", "virus", "VP16", "protein", "or", "with", "the", "activation", "region", "of", "the", "EBV", "R", "protein", "." ]

[ 0, 9, 10, 10, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 9, 10, 0, 0, 9, 10, 10, 0 ]

[ "The", "correlation", "is", "specific", "as", "the", "level", "of", "at", "least", "three", "other", "transcription", "factors", "did", "not", "change", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0 ]

[ "Upon", "mitogenic", "stimulation", ",", "the", "binding", "activity", "of", "the", "novel", "NF-AT-binding", "factor", "is", "rapidly", "down-regulated", "in", "normal", "T", "cells", ",", "but", "persists", "at", "high", "levels", "in", "Ipr", "CD4-8-", "T", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0 ]

[ "An", "in", "vitro", "binding", "site", "selection", "procedure", "was", "used", "to", "determine", "DNA", "sequences", "preferentially", "bound", "by", "wild-type", "HLF", "and", "chimeric", "E2A-HLF", "proteins", "isolated", "from", "various", "t", "(", "17", ";", "19", ")", "-bearing", "leukemias", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 6, 6, 0 ]

[ "Thus", ",", "STAT1", "may", "be", "a", "useful", "target", "in", "the", "development", "of", "new", "immunosuppressive", "and", "antineoplastic", "agents", "." ]

[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "However", ",", "replication", "of", "EBV", "in", "vivo", "is", "controlled", "primarily", "by", "host", "immune", "mechanisms", "selecting", "for", "cells", "that", "are", "not", "permissive", "for", "viral", "replication", "as", "the", "result", "of", "a", "particular", "set", "of", "transcription", "factors", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "The", "transfected", "cell", "lines", "expressed", "elevated", "levels", "of", "spi-1", "mRNA", "and", "protein", "and", "high", "Spi-1", "-DNA", "binding", "activity", "." ]

[ 0, 5, 6, 6, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 9, 0, 0, 0, 0 ]

[ "Stimulation", "was", "significantly", "higher", "when", "lysates", "were", "heated", "at", "100", "degrees", "C", "for", "5", "min", "but", "was", "reduced", "by", "treatment", "with", "lysozyme", "or", "protease", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0 ]

[ "Thus", ",", "constitutive", "activation", "of", "Egr-1", "gene", "is", "invariably", "associated", "with", "unrestricted", "expression", "of", "viral", "latent", "genes", "in", "all", "group", "III", "EBV", "genome", "carrying", "cell", "lines", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 6, 0 ]

[ "In", "one", "case", ",", "the", "PTT", "shift", "was", "explained", "by", "in-frame", "splicing", "out", "of", "exon", "10", ",", "in", "the", "presence", "of", "a", "normal", "exon", "10", "genomic", "sequence", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0 ]

[ "[", "Estrogen", "receptor", "content", "of", "peripheral", "blood", "lymphocytes", "in", "patients", "with", "systemic", "lupus", "erythematosus", "]" ]

[ 0, 9, 10, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0 ]

[ "NF-kappa", "B", "activation", "was", "independent", "of", "the", "transmembrane", "domain", "of", "CD40", ",", "suggesting", "that", "it", "is", "independent", "of", "p23", ",", "a", "molecule", "that", "associates", "with", "CD40", "in", "a", "region", "other", "than", "the", "cytoplasmic", "domain", "." ]

[ 9, 10, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "CD40", "is", "an", "important", "signaling", "and", "activation", "Ag", "found", "on", "certain", "bone", "marrow-derived", "cells", "." ]

[ 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]

[ "Binding", "assays", "using", "125I-labeled", "C-C", "chemokines", "in", "mammalian", "cells", "indicated", "that", "CHEMR1", "did", "not", "bind", "MIP-1alpha", ",", "RANTES", ",", "or", "MIP-1beta", ",", "whereas", "CCR-1", "binds", "MIP-1alpha", "and", "RANTES", "." ]

[ 0, 0, 0, 9, 10, 10, 0, 7, 8, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0 ]

[ "Finally", ",", "recovered", "protein", "was", "identified", "as", "genuine", "huGATA-3", "by", "SDS-PAGE", ",", "Western", "blotting", ",", "and", "bandshift", "assays", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "C/EBPepsilon", "mRNA", "was", "greatly", "induced", "during", "in", "vitro", "granulocytic", "differentiation", "of", "human", "primary", "CD34", "(", "+", ")", "cells", "." ]

[ 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 8, 8, 0 ]

[ "In", "this", "study", "we", "examined", ",", "by", "denaturing", "gradient-gel", "electrophoresis", "and", "DNA", "sequence", "analysis", ",", "the", "possible", "presence", "of", "a", "codon", "10", "polymorphic", "site", "in", "normal", "oestrogen", "target", "organs", "and", "cells", "such", "as", "the", "uterus", "(", "myometrium", "and", "endometrium", ")", ",", "in", "the", "placenta", "and", "peripheral", "blood", "mononuclear", "cells", "and", "in", "a", "benign", "uterus", "tumour", "(", "leiomyoma", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "To", "investigate", "the", "activity", "of", "a", "single", "transcription", "factor", "in", "individual", "viable", "cells", ",", "we", "have", "applied", "an", "assay", "that", "uses", "the", "fluorescence-activated", "cell", "sorter", "to", "quantitate", "beta-galactosidase", "(", "beta-gal", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0 ]

[ "An", "iron-responsive", "element", "(", "IRE", ")", "motif", "has", "been", "identified", "in", "the", "5'-untranslated", "region", "of", "the", "human", "erythroid", "ALAS", "mRNA", ",", "but", "is", "not", "present", "in", "the", "housekeeping", "ALAS", "mRNA", "." ]

[ 0, 3, 4, 4, 4, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0 ]

[ "Thereby", "an", "alternative", "type", "of", "La", "mRNA", "was", "identified", "that", "differed", "from", "the", "known", "La", "mRNA", "due", "to", "an", "exchange", "of", "the", "exon", "1", "." ]

[ 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "Within", "2", "to", "4", "h", "of", "PMA", "exposure", ",", "steady", "state", "levels", "of", "TNF", "mRNA", "are", "markedly", "elevated", "in", "all", "myelomonocytic", "cell", "lines", "studied", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0 ]

[ "Specificity", "was", "determined", "using", "tetanus", "toxoid", ",", "endotoxin", ",", "and", "3", "other", "autoantigens", "(", "PBC.M2", ",", "Sc170", ",", "and", "GAD", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 0, 9, 0, 0 ]

[ "While", "CD40", "ligation", "strongly", "activates", "the", "SAPKs", "(", "up", "to", "25-fold", ")", ",", "it", "does", "not", "affect", "members", "of", "the", "mitogen-activated", "protein", "kinase", "family", "(", "MAPK", ";", "ERK1", "and", "ERK2", ")", "." ]

[ 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 0, 9, 0, 9, 0, 0 ]

[ "The", "CMAT", "protein", "appears", "to", "be", "a", "novel", "inducible", "protein", "involved", "in", "the", "regulation", "of", "c-myb", "expression", "during", "T-cell", "activation", "." ]

[ 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0 ]

[ "Associated", "with", "the", "inhibition", "of", "the", "cell", "cycle", ",", "IL-10", "suppressed", "SEB", "induction", "of", "interleukin-2", "(", "IL-2", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 9, 0, 0 ]

[ "Autoregulation", "of", "the", "NF-kappa", "B", "transactivator", "RelA", "(", "p65", ")", "by", "multiple", "cytoplasmic", "inhibitors", "containing", "ankyrin", "motifs", "." ]

[ 0, 0, 0, 9, 10, 10, 9, 0, 9, 0, 0, 0, 9, 10, 0, 9, 10, 0 ]

[ "Secretion", "of", "myeloid", "cell-derived", "cytokines", "may", "both", "increase", "virus", "production", "and", "contribute", "to", "AIDS-associated", "disorders", "." ]

[ 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Examination", "of", "the", "basal", "factors", "interacting", "with", "the", "21", "bp", "repeat", "elements", "through", "electrophoretic", "mobility", "shift", "(", "EMS", ")", "analyses", "has", "demonstrated", "the", "formation", "of", "DNA-protein", "complexes", "common", "to", "each", "of", "the", "21", "bp", "repeats", "(", "C1-C3", ")", "as", "well", "as", "three", "DNA-protein", "complexes", "specific", "to", "the", "promoter", "proximal", "(", "pp", ")", "repeat", "(", "U1", "(", "U1A/U1B", ")", "and", "U2", ";", "1-4", ")", "." ]

[ 0, 0, 0, 9, 10, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 1, 2, 2, 0, 1, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 1, 2, 2, 2, 2, 2, 0, 1, 0, 1, 0, 0, 1, 0, 0, 0, 0 ]

[ "The", "Wilms", "'", "tumor", "gene", "(", "WT1", ")", "encodes", "a", "transcription", "factor", "of", "the", "zinc", "finger", "type", "." ]

[ 0, 1, 2, 2, 2, 0, 1, 0, 0, 0, 9, 10, 0, 0, 9, 10, 10, 0 ]

[ "Fifty-three", "cases", "(", "11", "AML", "M4Eo", ";", "1", "AML", "M4", "with", "atypical", "abnormal", "eosinophils", "(", "AML", "M4", "``", "Eo", "''", ")", ";", "29", "AML", "M4", ";", "8", "AML", "M5", ";", "3", "CMML", ";", "and", "1", "AML", "M2", "with", "eosinophilia", ")", "were", "analyzed", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Our", "results", "are", "consistent", "with", "the", "view", "that", "the", "DNA-binding", "activity", "LEF1/BCF1", "is", "a", "homodimer", "of", "E2A", "proteins", ";", "the", "selective", "appearance", "of", "this", "putative", "cell-specific", "transcription", "factor", "in", "B", "lymphoid", "cells", "seems", "to", "be", "attributable", ",", "at", "least", "in", "part", ",", "to", "the", "elevated", "E2A", "protein", "concentrations", "in", "these", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0 ]

[ "PLB-985", "cells", "represent", "a", "bipotential", "myelomonoblastic", "cell", "population", "capable", "of", "either", "granulocytic", "or", "monocytic", "differentiation", "after", "induction", "with", "appropriate", "inducers", "." ]

[ 5, 6, 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "E2A", "gene", "encodes", "transcription", "factors", "of", "the", "helix-loop-helix", "family", "that", "are", "implicated", "in", "cell-specific", "gene", "expression", "as", "part", "of", "dimeric", "complexes", "that", "interact", "with", "E", "box", "enhancer", "elements", "." ]

[ 0, 1, 2, 0, 9, 10, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 1, 2, 2, 2, 0 ]

[ "We", "have", "characterized", "the", "expression", "of", "STAT", "and", "IFN", "regulatory", "factor", "(", "IRF", ")", "family", "transcription", "factors", "in", "primary", "human", "blood", "mononuclear", "cells", "and", "macrophages", "in", "response", "to", "IFN-alpha", "and", "IFN-gamma", "stimulation", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 7, 8, 8, 8, 8, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "HLA", "Class", "II", "dependency", "was", "investigated", "using", "anti-Class", "II", "monoclonal", "antibodies", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0 ]

[ "The", "described", "conditions", "which", "inhibited", "or", "prevented", "the", "activation", "of", "the", "IL-1RI-associated", "kinase", "similarly", "impaired", "the", "activation", "of", "NF-kappa", "B", "in", "EL4", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 9, 10, 0, 5, 6, 0 ]

[ "Transient", "cotransfection", "of", "tat", "cDNA", "in", "sense", "orientation", "(", "tat/S", ")", ",", "together", "with", "a", "plasmid", "containing", "the", "c-fos", "promoter", "(", "FC3", ",", "from-", "711", "to", "+42", ")", "in", "front", "of", "the", "bacterial", "chloramphenicol", "acetyltransferase", "(", "CAT", ")", "gene", "significantly", "enhanced", "CAT", "activity", "in", "Jurkat", "cells", "activated", "by", "the", "addition", "of", "15", "%", "fetal", "calf", "serum", "(", "FCS", ")", "or", "5", "micrograms/mL", "phytohemagglutinin", "plus", "10", "(", "-7", ")", "mol/L", "phorbol", "myristate", "acetate", "(", "PMA", ")", "and", "U937", "cells", "activated", "by", "15", "%", "FCS", "or", "10", "(", "-7", ")", "mol/L", "PMA", "." ]

[ 0, 0, 0, 1, 2, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1, 0, 0, 1, 2, 0, 1, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0, 0, 9, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Here", ",", "we", "show", "that", "the", "DBF", "site", "is", "an", "interferon-responsive", "factor", "(", "IRF", ")", "binding", "site", "and", "that", "the", "AP3-L", "motif", "binds", "the", "T-cell-specific", "factor", "NF-AT", "." ]

[ 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0, 0, 0, 1, 2, 0, 0, 9, 10, 9, 0 ]

[ "There", "was", ",", "however", ",", "a", "significant", "difference", "in", "the", "amounts", "of", "the", "nuclear", "protein", ",", "REF-1", "(", "which", "regulates", "AP-1", "DNA", "binding", "by", "altering", "the", "redox", "status", "of", "FOS", "and", "JUN", "proteins", ")", ",", "in", "alveolar", "macrophages", "compared", "with", "monocytes", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 0, 0, 0, 7, 8, 0, 0, 7, 0 ]

[ "Alveolar", "macrophages", "play", "an", "important", "role", "in", "host", "defense", "and", "in", "other", "types", "of", "inflammatory", "processes", "in", "the", "lung", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "predictive", "protein-coding", "region", "of", "RP1", "had", "a", "significant", "homology", "to", "members", "of", "the", "recently", "found", "adenomatous", "polyposis", "coli", "(", "APC", ")", "protein-binding", "EB1", "gene", "family", ",", "which", "codes", "for", "yet", "unknown", "protein", "(", "s", ")", "." ]

[ 0, 1, 2, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Dephosphorylation", "of", "ZAP-70", "and", "inhibition", "of", "T", "cell", "activation", "by", "activated", "SHP1", "." ]

[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "Here", "we", "show", "that", "the", "binding", "of", "calcineurin", "to", "NFAT", "is", "substantially", "increased", "when", "calcineurin", "is", "activated", "with", "calmodulin", "and", "calcium", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0 ]

[ "We", "demonstrate", "that", "mRNAs", "for", "all", "three", "of", "these", "regulatory", "factors", "are", "expressed", "in", "fetal", "blood", "cells", "by", "the", "27th", "week", "of", "gestation", "and", "in", "term", "cord", "bloods", "." ]

[ 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Mutational", "analysis", "of", "UAS1", "sequences", "combined", "with", "in", "vitro", "bandshift", "assays", "revealed", "the", "presence", "of", "three", "binding", "sites", "for", "cellular", "factors", "in", "this", "region", "." ]

[ 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 9, 10, 0, 0, 0, 0 ]

[ "When", "compared", "with", "normal", "cells", ",", "the", "activation", "of", "NF-kappa", "B", "activity", "in", "SLE", "patients", "was", "significantly", "decreased", "in", "SLE", ",", "but", "not", "in", "RA", ",", "patients", "." ]

[ 0, 0, 0, 7, 8, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Subsequently", ",", "I", "kappa", "B-alpha", "mRNA", "and", "protein", "levels", "are", "quickly", "induced", "by", "the", "activated", "NF-kappa", "B", "." ]

[ 0, 0, 3, 4, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "The", "present", "work", "demonstrates", "that", "the", "glucocorticoid", "dexamethasone", "inhibits", "TPA-induced", "increases", "in", "c-jun", "and", "c-fos", "mRNA", "levels", "in", "U-937", "leukemia", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0 ]

[ "Expression", "plasmids", "encoding", "regions", "of", "RFX5", "fused", "to", "the", "GAL4", "DNA", "binding", "domain", "activated", "transcription", "from", "a", "reporter", "construct", "containing", "GAL4", "sites", "in", "a", "cotransfection", "assay", "in", "the", "Raji", "human", "B", "cell", "line", "." ]

[ 1, 2, 0, 0, 0, 9, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0 ]

[ "The", "son", "of", "the", "unaffected", "twin", "sister", "was", "shown", "to", "be", "hemizygous", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "HTLV-I", "encodes", "a", "potent", "transactivator", "protein", "termed", "Tax", "that", "appears", "to", "play", "an", "important", "role", "in", "the", "process", "of", "T-cell", "immortalization", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Induction", "of", "CD8", "antigen", "and", "suppressor", "activity", "by", "glucocorticoids", "in", "a", "CEM", "human", "leukemic", "cell", "clone", "." ]

[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0 ]

[ "These", "studies", "therefore", "suggest", "that", "basal", "level", "GR", "expression", "is", "inadequate", "to", "mediate", "glucocorticoid-induced", "apoptosis", "in", "glucocorticoid-sensitive", "T", "cells", "and", "that", "positive", "autoregulation", "is", "a", "necessary", "component", "of", "this", "process", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "therefore", "speculate", "that", "N-Oct-3", "and", "other", "N-Oct", "factors", "have", "a", "specific", "role", "in", "gene", "expression", "in", "cells", "of", "the", "nervous", "system", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Inclusion", "of", "this", "LTR", "in", "recombinant", "SIVs", "also", "resulted", "in", "a", "two-", "to", "threefold", "rise", "in", "the", "extent", "of", "cellular", "proliferation", "that", "was", "induced", "in", "quiescent", "simian", "peripheral", "blood", "mononuclear", "cells", "." ]

[ 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 0 ]

[ "It", "appears", "that", "a", "basal", "redox", "equilibrium", "tending", "toward", "oxidation", "is", "a", "prerequisite", "for", "full", "activation", "of", "transduction", "pathways", "regulating", "the", "activity", "of", "NF-kappa", "B-dependent", "genes", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]

[ "Furthermore", ",", "the", "results", "obtained", "with", "TNF", "alpha", "proved", "that", "NF-kappa", "B", "activation", "was", "not", "sufficient", "for", "induction", "of", "neuroblastoma", "differentiation", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0 ]

[ "When", "a", "therapy", "proves", "effective", ",", "do", "clinicians", "truly", "know", "how", "it", "works", "?", "Even", "with", "a", "therapy", "as", "specific", "as", "anti-TNF", "antibody", ",", "it", "is", "not", "clear", "if", "the", "benefit", "is", "attributable", "to", "simple", "binding", "and", "clearance", "of", "TNF-alpha", "or", "to", "binding", "on", "the", "cell", "surface", "and", "subsequent", "deletion", "of", "the", "activated", "macrophage", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]

[ "The", "GTPase", "Rho", "is", "known", "to", "mediate", "the", "assembly", "of", "integrin-containing", "focal", "adhesions", "and", "actin", "stress", "fibers", "." ]

[ 0, 9, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "A", "fragment", "of", "Oct-2", "containing", "POUHD", "and", "an", "adjoining", "linker", "was", "expressed", "in", "Escherichia", "coli", "and", "characterized", "by", "three-dimensional", "nuclear", "magnetic", "resonance", "(", "3D-NMR", ")", "spectroscopy", "." ]

[ 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "mitogen-induced", "increase", "of", "c-Fos", "and", "c-Jun", "immunoreactivity", "was", "inhibited", "by", "H-7", ",", "a", "kinase", "inhibitor", "with", "relatively", "high", "specificity", "for", "PKC", ",", "and", "less", "efficiently", "by", "H-8", ",", "a", "structurally", "related", "kinase", "inhibitor", "less", "active", "on", "PKC", ",", "but", "more", "active", "on", "cyclic", "nucleotide-dependent", "kinases", "." ]

[ 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "suggest", "that", "HIV-1", "infection", "of", "myeloid", "cells", "induces", "IFN", "production", "and", "PKR", "activity", ",", "which", "in", "turn", "contribute", "to", "enhanced", "IkappaBalpha", "phosphorylation", "and", "subsequent", "degradation", "." ]

[ 0, 0, 0, 0, 0, 0, 7, 8, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0 ]

[ "One", "of", "these", "NFAT-like", "elements", "encompassed", "overlapping", "Oct-", "and", "NFATp/c-binding", "sites", ",", "which", "functioned", "in", "a", "highly", "synergistic", "manner", "." ]

[ 0, 0, 0, 1, 2, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Peripheral", "blood", "monocytes", "were", "isolated", "by", "density", "centrifugation", "methods", "with", "a", "purity", "of", ">", "90", "%", "and", "were", "cultured", "in", "RPMI", "1640", "medium", "." ]

[ 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Multicolor", "flow", "cytometric", "assays", "confirmed", "the", "coexpression", "of", "myeloid", "(", "CD33", ",", "CD13", ",", "CD15", ")", "and", "NK", "cell-associated", "(", "CD56", ")", "antigens", "in", "each", "case", ",", "whereas", "reverse", "transcription", "polymerase", "chain", "reaction", "(", "RT-PCR", ")", "assays", "confirmed", "the", "identity", "of", "CD56", "(", "neural", "cell", "adhesion", "molecule", ")", "in", "leukemic", "blasts", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 10, 10, 10, 0, 0, 7, 8, 0 ]

[ "Human", "RXR", "alpha", "was", "significantly", "expressed", "in", "U937", "and", "THP-1", "cells", ",", "weakly", "expressed", "in", "H9", "cells", "and", "not", "detectable", "in", "CEM", "cells", "." ]

[ 9, 10, 10, 0, 0, 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 5, 6, 0 ]

[ "Similar", "DNA", "binding", "activity", "was", "detected", "in", "a", "variety", "of", "virus-uninfected", "human", "T", "cell", "lines", "and", "HeLa", "cells", "by", "means", "of", "a", "gel", "mobility", "shift", "assay", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "First", ",", "previous", "studies", "have", "shown", "this", "integrin", "to", "be", "particularly", "prone", "to", "proteolytic", "regulation", "of", "its", "function", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Globin", "gene", "switching", "." ]

[ 0, 0, 0, 0 ]

[ "Surprisingly", ",", "multimers", "of", "kappa", "1-kappa", "3", "can", "confer", "PMA", "inducibility", "on", "a", "heterologous", "promoter", "in", "a", "B", "(", "Raji", ")", ",", "but", "not", "a", "T", "(", "HUT78", ")", "cell", "line", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 5, 6, 6, 6, 6, 6, 6, 6, 6, 6, 6, 6, 6, 6, 0 ]

[ "With", "these", "clones", ",", "we", "demonstrated", "that", "NFAT", "activation", "induced", "by", "phorbol", "12-myristate", "13-acetate", "and", "ionomycin", "was", "inhibited", "by", "both", "cyclosporin", "A", "(", "CsA", ")", "(", "IC50", "=", "8", "nM", ")", "and", "FK506", "(", "IC50", "=", "160", "pM", ")", ",", "presumably", "by", "inhibition", "of", "calcineurin", "activity", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

[ "Three", "3rd", "base", "substitution", "polymorphisms", "were", "also", "detected", "during", "direct", "sequencing", "of", "PCR", "products", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "This", "observation", "is", "consistent", "with", "the", "detection", "of", "normal", "CD40", "-induced", "monocyte", "activation", "in", "patients", "with", "CD40", "ligand+", "hyper", "IgM", "syndrome", "in", "whom", "a", "defect", "in", "CD40", "-induced", "B", "cell", "activation", "has", "been", "reported", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Together", ",", "these", "findings", "suggest", "that", "the", "nuclear", "localization", "signal", "and", "transactivation", "domain", "of", "NF-kappa", "B", "p65", "constitute", "a", "bipartite", "system", "that", "is", "critically", "involved", "in", "the", "inhibitory", "function", "of", "I", "kappa", "B/MAD-3", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]

[ "We", "have", "investigated", "mechanisms", "and", "consequences", "of", "STAT5", "activation", "through", "the", "human", "IL-4", "receptor", "(", "IL-4R", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0 ]

[ "We", "demonstrate", "that", "the", "transcriptional", "activity", "of", "GATA-1", "is", "strongly", "repressed", "by", "the", "estrogen", "receptor", "(", "ER", ")", "in", "a", "ligand-dependent", "manner", "and", "that", "this", "repression", "is", "reversible", "in", "the", "presence", "of", "4-hydroxytamoxifen", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "distribution", "of", "this", "integral", "membrane", "protein", "is", "restricted", "to", "certain", "tissues", "where", "its", "level", "of", "expression", "is", "modulated", "by", "multiple", "exogenous", "stimuli", "." ]

[ 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Furthermore", ",", "in", "vitro", "mutagenesis", "experiments", "demonstrated", "that", "inducible", "interleukin-2", "enhancer", "function", "requires", "the", "presence", "of", "either", "EBS1", "or", "EBS2", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0 ]

[ "In", "the", "search", "for", "a", "potential", "treatment", ",", "we", "have", "tested", "tyloxapol", ",", "an", "alkylaryl", "polyether", "alcohol", "polymer", "detergent", "previously", "used", "as", "a", "mucolytic", "agent", "in", "adult", "chronic", "bronchitis", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Our", "findings", "demonstrate", "an", "essential", "role", "of", "NF-kappa", "B", "in", "survival", "of", "naive", "PBL", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 7, 8, 0 ]

[ "Indeed", ",", "addition", "of", "inhibitors", "of", "NF-kappa", "B", "activation", "pyrrolidine", "dithiocarbamate", "(", "PDTC", ")", ",", "to", "the", "lymphocytes", "of", "the", "chemically-exposed", "group", "was", "capable", "of", "inhibiting", "programmed", "cell", "death", "by", "40", "%", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "IL-2", "enhancer", "contains", "a", "functional", "motif", "named", "CD28", "response", "element", "(", "CD28RE", ")", "that", "serves", "a", "role", "as", "a", "target", "for", "mitogenic", "T", "cell", "activation", "signals", "." ]

[ 0, 9, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "E3330", "decreased", "activated", "NF-kappa", "B", "in", "nuclei", ",", "suggesting", "that", "E3330", "inhibits", "NF-kappa", "B", "activation", "and/or", "translocation", "of", "the", "nuclei", "." ]

[ 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "high", "concentration", "of", "foreign", "antigen", "in", "the", "lumen", "of", "the", "gastrointestinal", "tract", "is", "separated", "from", "the", "underlying", "lymphocytes", "by", "a", "single", "cell", "layer", "of", "polarized", "epithelium", "." ]

[ 0, 0, 0, 0, 9, 10, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "induction", "of", "gene", "transcription", "in", "response", "to", "gamma", "interferon", "is", "impaired", "in", "mononuclear", "phagocytes", "infected", "with", "Leishmania", "donovani", ",", "and", "the", "mechanisms", "involved", "are", "not", "fully", "understood", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Inhibition", "of", "PI3K", "inhibits", "phosphorylation", "of", "Rb", ",", "induction", "of", "cyclin", "D3", ",", "and", "degradation", "of", "p27kip1", "." ]

[ 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 0 ]

[ "A", "newly", "established", "megakaryoblastic/erythroid", "cell", "line", "that", "differentiates", "to", "red", "cells", "in", "the", "presence", "of", "erythropoietin", "and", "produces", "platelet-like", "particles", "." ]

[ 0, 0, 0, 5, 6, 6, 0, 0, 0, 7, 8, 0, 0, 0, 0, 9, 0, 0, 7, 8, 0 ]

[ "These", "diurnal", "variations", "in", "GR", "might", "serve", "to", "coordinate", "the", "reactivity", "of", "the", "target", "cells", "to", "cortisol", "because", "the", "diurnal", "rhythms", "of", "a", "GR", "-mediated", "response", ",", "the", "fractional", "inhibition", "of", "chemotactic", "migration", "rate", "of", "polymorphonuclear", "leukocytes", "by", "cortisol", ",", "were", "found", "to", "be", "synchronous", "with", "those", "of", "GR", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]