kuleshov-group/PlantCaduceus_l24

Model Overview

PlantCaduceus is a DNA language model pre-trained on 16 Angiosperm genomes. Utilizing the Caduceus and Mamba architectures and a masked language modeling objective, PlantCaduceus is designed to learn evolutionary conservation and DNA sequence grammar from 16 species spanning a history of 160 million years. We have trained a series of PlantCaduceus models with varying parameter sizes:

• PlantCaduceus_l20: 20 layers, 384 hidden size, 20M parameters
• PlantCaduceus_l24: 24 layers, 512 hidden size, 40M parameters
• PlantCaduceus_l28: 28 layers, 768 hidden size, 112M parameters
• PlantCaduceus_l32: 32 layers, 1024 hidden size, 225M parameters

How to use

from transformers import AutoModel, AutoModelForMaskedLM, AutoTokenizer
import torch
model_path = 'kuleshov-group/PlantCaduceus_l24'
device = "cuda:0" if torch.cuda.is_available() else "cpu"
model = AutoModelForMaskedLM.from_pretrained(model_path, trust_remote_code=True, device_map=device)
model.eval()
tokenizer = AutoTokenizer.from_pretrained(model_path, trust_remote_code=True)

sequence = "ATGCGTACGATCGTAG"
encoding = tokenizer.encode_plus(
            sequence,
            return_tensors="pt",
            return_attention_mask=False,
            return_token_type_ids=False
        )
input_ids = encoding["input_ids"].to(device)
with torch.inference_mode():
    outputs = model(input_ids=input_ids, output_hidden_states=True)

Citation

@article {Zhai2024.06.04.596709,
    author = {Zhai, Jingjing and Gokaslan, Aaron and Schiff, Yair and Berthel, Ana and Liu, Zong-Yan and Miller, Zachary R and Scheben, Armin and Stitzer, Michelle C and Romay, Cinta and Buckler, Edward S. and Kuleshov, Volodymyr},
    title = {Cross-species plant genomes modeling at single nucleotide resolution using a pre-trained DNA language model},
    elocation-id = {2024.06.04.596709},
    year = {2024},
    doi = {10.1101/2024.06.04.596709},
    URL = {https://www.biorxiv.org/content/early/2024/06/05/2024.06.04.596709},
    eprint = {https://www.biorxiv.org/content/early/2024/06/05/2024.06.04.596709.full.pdf},
    journal = {bioRxiv}
}

Contact

Jingjing Zhai (jz963@cornell.edu)