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in this work a convolutional neural network kgcnlv which integrates the curriculum knowledge graph is proposed to obtain students personalized potential interests by aggregating neighborhood information through the experiments on the datasets moocmusic and mooccomputer it can be seen that kgcncr is always better than the baseline indicating that the course recommendation method integrating knowledge graph is better than the traditional course cf recommendation method and can accurately implement course resource recommendation i am generally positive with manucript however before publication i think this version should be improved based on the following commentsa the recommendation system can carefully recommend informative courses to students among many educational resources by analyzing the relevant historical data of students on the mooc platform please show me some histrocial datab deep disruptive form

dear editorthank you for inviting me to review the articleregulatory effects of fyn on trophoblast behaviors and function in this article the author investigated the influence of fyn on trophoblast behavior and function overall the article is well organized and its presentation is good here are the comments on this articlemajor commentsthis study revealed the effect of fyn on trophoblast behaviors although trophoblast behaviors are associated with many pregnancy complications the authors did not further validate fyn function in pregnancy complications it is suggested to supplement clinical samples experiment based on pregnancy comorbidities moreover the specific mechanism of fyns regulation of trophoblast cell function was not thoroughly studied in this studymajor commentsin the materials and methods this study using universal tyrosine kinase assay kitmk takara bio otsu japan

reviewer commentsthe limitations of the study were not discussed which does not fit the criticality of a scientific research articlethere is no need to indent the first line in english writingi can understand that this research can lay the groundwork for finding new therapeutic targets so why search for new therapeutic targets in other words what are the disadvantages of current treatment methods

i reviewed the entire paper and discovered that it requires extensive rewriting although this papers work is excellent i have certain points that must be addressed as a result i will decide on publishing this work later for the time being i propose a major revision it is recommended that the authors of this study thoroughly examine my remarks and suggested improvements the following are my observationssuggestionsthe other thing that i have noticed in most of the places the authors have used the word formula i suggest this word be changed to equation which is more suitable in a paperin section of the paper the authors have used resnet but have not mentioned its full form and flowchart i suggest writing the full form of resnet and writing

this article is based on the research of the display design model of the prototype system of the internet of things in order to realize an application prototype system of the internet of things and improve the data sharing to a certain extent the display design model based on the prototype system of the internet of things is studied the article has good usability but there are also certain flaws the abstract part gives a good introduction to the main research content of the article but when describing the experimental part only relying on experimental data is not sufficient and it needs to be explained in conjunction with certain conclusions previous research has carried out indepth research on the internet of things from various angles what are the

with the rapid development of the market economy peoples material living standards have been greatly improved and food hygiene and safety issues have attracted more and more attention the whole content is substantial but a lot of theoretical knowledge is not detailed enough i hope it can be enriched however the food industry is developing faster and faster and the requirements for food information testing and safety are becoming more and more strict why do food testing this paper applies it to the research of electronic nose for food nondestructive testing which has very important practical value and significance for promoting the comprehensive intelligence of food testing can you add specific meaning in order to further study the feasibility of applying electronic nose to seed viability detection load

under the background of the continuous progress of science and technology the trend of global integration is further enhanced and the relationship between countries is getting closer and closer foreign affairs translation system plays a very important role and many scientific and technological projects have carried out research and analysis around foreign affairs translation system based on the application and analysis of big data mining in foreign affairs translation system this paper analyzes the current development status of big data mining technology and the existing problems of foreign affairs translation system and analyzes the foreign affairs translation system according to big data mining technology which determines the technical support for this research the following questions are raised for the content of the article please refer to the revision

collaborative filtering recommendation is an important and interesting project in the case of extremely sparse data this work proposes to combine the slope matrix prefilling model principal component reduction of binary kmeans clustering for collaborative filtering recommendation this particular the proposed method establishes a relatively perfect computing system and reduces the dimension of the prefilled score matrix by principal component analysis and ensures the efficiency and accuracy of the collaborative filtering recommendation algorithm by its kmeans clustering the idea is interesting and relevant enough for this topic and the technique line is reasonable the experimental results show that the proposed method is superior to the current numerical filtering algorithm and validate the effectiveness especially in the case of sparse data tables this article is well organized on the

manuscript is interesting but the authors used mainly in silico studies to prove the huoluo xiaoling pellets treating cerebral ischemic stroke to make the authors should do following changes to make the manuscript acceptablemore information in introduction about cerebral ischemic stroke is needed what is its incidence what factor contribute to the risk of cerebral ischemic stroke what are the current treatment options include recent studies for all these pointsrelated to huoluo xiaoling pellets how authors decided to carry study on these pellets are there any background studies to strengthen the rationale of the study authors should provide strong evidence from literaturethere are many typing errors authors should check the manuscript careful and correct all linguistic errorsdiscussion can be improved results should be discussed in the light of

the research contribution is not clearthe abstract should include problem statement methodology resultsthis section is not clear some of the limitations of employing itc in paz domain binding experiments were the demand for large quantities of paz purified protein the instability of the paz domain which necessitated the use of particular precautions throughout the expression and purification processes the relatively long itc run running itc at low temperature c inability to use stabilizing solutions to avoid excessive background heat during itc titrations due to technical limitations lower number of titration injectionsdiscussion more details and discussion are needed in the discussion section

in a constantly aging business model enterprise human resource demand forecasting plays an important role in logistics activities by efficiently guiding a lot of activities and improving commercial competitive advantage to hr forecast product demand traditional approaches often include statistical methods such as exponential smoothing or lower cost moving average methods however many researchers are only interested in quantitative data such as empirical data even though qualitative data has a stronger influence on product demand in the actual world the use of enterprise human resource demand forecasting as a major topic currently many researchers have focused on enhancing mathematical statistics and human resources in ways demand forecasting may be improved and the accuracy of enterprise cultural resource consumption reference values can be improved the authors of this study

the manuscript titled identification of prognostic mirnas targeting ezh in hepatocellular carcinoma using the cancer genome atlas synthesis and in vitro validation by lin et al provides an original information about the therapeutic potential of mirs targeting ezh this data may prove beneficial in diagnosis and monitoring of progression and hcc in need authors attentionall bioinformatics analysis showed be best described all the information every parameter should be provided so that the results are reproduciblewere the culturing is same for all animals if there were any variations in culturing please mentionwhat concentration of the constructs letcp this rna inhibitor etc was used for transfection no write itin the transwell assay what was the difference in media between upper and lower chamberresults are nicely presented but many linguistic errors

i have read the paper the paper is good but the following comments should be addressed in the revised papersome of the headings of this paper are written in the italic size i suggest to the authors please resolve this issuethe papers abstract must be concise please make it more logically continuousi noticed the the radical gastrectomy section is the keywords point but i cannot see any debate in the paper about this section also resolve this issuethe concluding sections first sentence is ambiguous i think the authors should work on their first language in the concluding partalso define a clear difference between data sources and selection and the general data of enrolled patientsearly postoperative complications occurred in of patients why give a reasonthe values of the analysis

authors must add more specific information about intrusion detection systems in the proposed studythe manuscripts language has to be significantly improved long sentences and grammatical faults must be avoided by the authorsadd more discussion regarding figure where the authors try to describe the machine learning techniques for design of intrusion detection systems for big data networksrevise the paper and remove all grammatical and punctuation errors also remove unnecessary spacing between the figures and paragraphsauthors should briefly discuss correlation feature selection method cfsutilizing the internet to manage their resources and transactions is proving to be beneficial for businesses across a wide range of industries justify the statement

in this study the authors argued that among tdm nonsurgical inpatients vte risk can be reliably predicted using a nomogram built on clinical and laboratory parameters in general the work is of interest but there are still some problems that need to be modifiedthe article has some problems of improper use of grammar so it is suggested to modify itin introduction this paper should accentuate his contributions in this manuscriptalso the introduction about related work should be reviewed more deeplypaper analyzes the results of others in the past is not deep enough in addition the list of references is not in our style it is close but not completely correct

in the manuscript entitled protective effect of thioredoxin against the ischemiareperfusion flap in cells through askmapk apoptosis signaling pathway niu etal found that the content of calcium in skin flap cells of ir mice decreased significantly and the apoptosis pathways of askmapk cells specifically as clcaspase ask and pp were activated and their expression by it indicated when trx was somehow related to the flap ir injury and the injury was achieved through the askmapk cell death signaling pathway in a word his experimental design and method innovation are good and the research on the specific mechanism is indepth there were some comments on this papercheck the figure above as in page the font of figures captions needs to be modifiedrewrite the abstract sectionthere are a couple of

this article is comprehensive and full of discussion in the process of studying the coordination and supervision method of administrative law in the field of rural governance based on the perspective of ecological environment a more rigorous demonstration method is used the chart is intuitive and concise and the theme is clear but there are some minor details that need to be resolved in the abstract section of the article this paper used various algorithms to study how to learn to improve the rural ecological environment why not describe the specific algorithm please add it in the abstract section of the article at present farmers insufficient understanding of environmental governance has weakened their external motivation excessive government intervention strong restriction of funds rural environmental legal system construction and

this definition proposes the mlmpfs model ideological and political elements in different fields are mapped to the same pseudolabel space through multiple linear mapping secondly the sample space characteristic manifold of ideological with political elements are needed to constrain my learning of pseudolabel and the feature weight matrix respectively within my point of view the following suggestions can improve the quality of your paperthe object by use mlmpfs algorithm is extract the parametersthe performance of the mpmlfs algorithm from diende data sets is slightly different did the author choose indexs for validationin the articleis the design method mpmlfs suitable for big data scenewhat is the range of the independent data in formulathank you for your professional advice and carefully reading we have shown the the value range of

the article under review aims to systematically evaluate the efficacy and safety of moxibustion as an adjuvant treatment or used alone for treatment however the result means that he efficacy and validity of moxibustion for asthma in humans still have not been proven here are some concerns exist few included literatures and the quality of included literatures extremely low however the use of moxibustion for treating asthma sounds slightly unbelievable because asthma sufferers may dislike the aromatic smell to moxa smoke which can subsequently trigger asthma attacks there are several tcm treatments to treat asthma why this study is focusing on moxibustion moxibustion combined with antiasthmatic drugs or treatment alone vs antiasthmatic drugs are antiasthmatic drugs the same there are no diagnostic criteria of asthma in this article

this article is a research on metapragmatic awareness in english interpreting from the perspective of artificial intelligence technology in order to improve the level of machine interpreting technology and enhance the awareness of metapragmatics in english interpreting this paper studies the english interpreting system based on artificial intelligence technology it is compared with traditional machine interpretation results the article has good usability but there are also certain flaws when the article introduces the main content of this study in the abstract part it mentions that the article has conducted indepth research on four aspects of metapragmatic theory review it is better to explain the specific research content here to make the structure of the article more clear and specific the article gives a detailed introduction to the development

author attempts to characterize the role that butylphthalide in combination with edaravone as a prognostic treatment for acute ischemic strok manuscript is well written and explained can be accepted with the following comments below are some comments to further considerthe initial problemwhat is the current epidemiology underlying ischemic stroke that would give a better picture of how many people have had it nowwhat are the symptoms of ischemic stroke each author should only introduce information at some lengththe original author refers to routine medications but what do you mainly consist of and what are the limitations of current treatmentsthe authors of this study chose this in combination with edaravone asking what are the advantages of these two drugs why did the authors choose these two drugsfrom the title

i am glad to have the opportunity to read application value of evidencebased nursing in pipeline nursing of aged bedridden patients but there are several problems that need to be discussed there are some grammar mistakes please revise when the abbreviation first appears the full name should be given please provide specific measures for patient pipeline management and suggest presenting them in the form of tables discussion should include main summary of the major results of the study and comparing the study with previous ones new hypothesis and direction might be proposed in the discussion section there have been some similar studies what is the innovation of this study please added

this paper proposes a commodity sales prediction method based on the chemical combination of cnnbilstm the bilstm network model of product performs the next prediction and weights the prediction results without the two models to finally obtain the prediction accuracy the experimental results show that the prediction accuracy can improve and compared with several other network models each evaluation parameter has better performanceas to next paper the reviewer has the following comments in the introduction of this paper the authors give the literature review on the parameter selection this is difficult for the readers to understand the introduction of this paper we have carefully clarified by the authors the authors may show more results and give some more explanation on the bilstm network structure some more explanations should

the experimental results of this paper show that the use of big data and artificial neural networks to study chinese dependency parsing methods has higher accuracy compared with the base analysis algorithm the accuracy rate is increased by which can indicate the continuation of the research such experimental methods are very satisfactory but in other aspects by the paper there are still some problems that draw attention the first paragraph of the introduction introduces the research status of syntactic analysis methods it is mentioned that the early research was mainly based in classical rulebased method and later the statistical method became the mainstream however it is no connection through these two sentences please make appropriate supplements introduction the third paragraph from the literature is about the application of

abstract should include more content on the main achievements of the study develop the literature review section by conceptual model structure needs to be improved his research objectives and methods be unclear and should be better explained the motivated the research objectives and methodology should be better explained and motivated the results and analysis section is overall should be better analyzed and developed further and compare the optimum situation with the current research develop scientific conclusions section to include the unique contributions of the paper theoretical and managerial implications limitations of the research must be added authors should debate their limitations in detail presentation in the conclusion section the authors have not discussed the advantages of the proposed methods

this paper summarizes the three major ecological problems faced by cities ecological problems production problems and life problems on the basis of clarifying the problems the following questions need to be revise what is the difference between the eastward planning in the title of the paper and the eastern tianjin planning in the abstract the expression proportion of urbanization in the introduction is wrong the gdp data in figure is inconsistent with the published data of chengdu over the years the unit of carbon emissions in figure is wrong verify the mapping data and redraw figure

the paper entitled pirfenidone alleviates intrauterine infectioninduced lung injuries by targeting tgf smad signaling pathway by ding et al is about the histological damages in neonatal after intrauterine infection and assesses the potential protective effect of pirfenidone pfd the paper has novel methods and results moreover the study has significance in the healthcare domain however there is room for improvement if the following comments are taken into accountiit is better not to use symbols in the title of a paper unless they are very necessary to use hence authors should reconsider writing iiin the abstract conclusions should be conclusions the background should be background and objectivesiiikeywords should be alphabetically arranged in ascending orderivthere are too many acronyms used in the paper therefore a list of acronyms should be

the work changes of aim il il expression in patients with acute cerebral infarction after mechanical interventional thrombectomy with solitaire fr stent showed that the levels of aim il and il were positively correlated with nihss score the higher the levels of aim il and il the more severe the brain injury and inflammatory reaction which can be used as a reference index to predict the prognosis of patients after mechanical interventional thrombectomy with solitaire fr stent but the article has some issues that need further revisiona in exclusion criteria part the sentence like history of previous stroke should be changed as those with history of stroke also the other sentence should be changed b g id appears in many places in the text what is it stand

one purpose of this application is to explore the expression levels and clinical significance of ki and sex determining the ybox sox in colorectal cancer it seems that the proposed algorithm works well than the simulation results however there are several technical and presentation problems needed should be solved one abstract i think the authors should add the specific and quantitative advantages description of the author the paper should further standardize the format from order to make it suitable for journal publication such as keywords and authors information in section the author should analyze the causes of colorectal cancer please ask someone familiar with english language to help you rewrite this article you will see i have made some correction at the beginning in the paper where some

figure is not clear please provide a better quality or larger imageplease review the equationsthe description of section should be deliberated at the start of each section to give an overview to the readersimprove the conclusion sectionwrite a few lines to describe the figures and

the research goal materials methods results and conclusion should all be included in the abstractthe contribution of the research is unclearwhat is the meaning of this textdespite the fact that bmi was utilized widely in exploration and clinical practice study recommends that there was a definitive proof for benchmark bmi limits for obesity seem to underrate body adiposity body mass index equivalent to or more than thirty has ability to correctly recognizing excess adiposity implying that of thin persons with an increased body fat fraction will not be considered obesediscussion to be more understandable the discussion section requires more details and discussion

the paper under review aims to enlarge the discussion over the solvability of certain differential problems of parabolic equations referring to the theory of variable exponents lebesgue and sobolev spaces the structure of the work is well built first a review of the literature is given then the necessary mathematical background to understand the essence of the manuscript is collected then the main results are established the proofs of results seem mathematically correct and easily understandable hence new at the best of our knowledge the authors should check the manuscript for spelling and language mistakes for example on page correct on line monograph on line works on line functions on line change dot by cdot on page correct on line banach space on line corollary on line our

this paper is a very innovative idea by metaanalysis of the screening indicators for diabetic patients and the evaluation of the way of consultation i suggest that the paper be published in this journal but there are some problems that need to be solved the abstract of the paper written does not meet the format of the magazine published it is recommended that the paper be summarized and condensed into the required it is recommended that the background of the paper the research methods and results the conclusion of the summative exposition which better meets the requirements of publication the papers references in the article cited in the incorrect format it is recommended to modify for other conform writing grammar issues to be improved the thesis coauthors work

secure data transmission for quality of service analysis and evaluation in industrial systems in this paper some information are needs to be corrected to improve the quality of the paper in the abstract the contributors should mention which parameters are considered for performance evaluations why ecc algorithm is implemented in the proposed work mention its advantages explain the proposed secure user authentication protocol and its main advantages explain multifactor authentication mfa and how it will be useful in the work mention the objective of the work proposed and its advantages of implementation the work needs a proper description of the proposed work and techniques used to improve the existing models

due to the discussion and empirical analysis in this paper the authors marketing strategy of government microblogs is novel and helpful for the netizens emotions adjustment which is better than standard methods i think this paper is very interest enough this manuscript can be accepted for publishing in journal of healthcare engineering with the following minor changes description style material like this manuscript requires structured tables figures provided better presentationsin its part the paper should point out the drawbacks of traditional sentiment classification methods and introduce the purpose of this paper more clearlyin section the review of related works is not enough there are some recent related works but not described in the manuscriptthe empirical results shall be described and explained clearly to show the effectiveness of the

this manuscript does not modify any unsupervised anomaly detection algorithms instead it combines the results of multiple anomaly detection algorithms to improve the accuracy of detection the idea is interesting and the result is great the mf model proposed in this manuscript can combine the results of different anomaly detection algorithms to obtain a comprehensive anomaly scorehowever there are still certain issues that are outlined below the comparing results of five unsupervised baseline algorithms for anomaly detection and the mf model based on naive bayes fusion method are shown in table and table respectively in this experiment only the results of naive bayes are shown the results of the other two fusion methods should also be presented what is the basis of the fusion model proposed in this

with the deepening of education reform and quality education concept and the continuous penetration of studentbased education concept colleges and universities in the process of education management gradually improve the importance of flexible management hope through flexible management to effectively improve management quality the students as the core of education management workcompared with rigid management flexible management is more flexible but also can get more support and cooperation from studentsbased on the professional characteristics of college teachers in order to change and improve the state internal mechanism enhance and realize the life value of university teachers structure this paper proposes the importance of flexible management construction of university teachers and promoting the harmonious coexistence of internal and external ecological factors however this paper still has the following problems

the paper presents results of experiments based on applying selected machine learning techniques to an example dataset for depression detection in professional mothers the authors applied svm and random forest classification techniques although we found that your paper has merit it is not acceptable to publish in its present form you are required to revise your paper to address following comments as given belowa thorough proofreading is recommended for quality improvement especially in the section materials and methodologythe manuscript presents only experimental results in the section effects of model but detailing the algorithm showing the highest accuracy is missing it is recommended to use some more case studiesexplanation is required for the training and test data in the development of models sectionthe steps of the selected machine learning

grammatical correction is required at the sentence concrete using other aci language in abstractwhat would be the reason for decrease in strength give justification low water level ggbfs which is mentioned in capital letters in paper it needs all be changed provide the application of this study in abstract language is the problem of opting marine solution for durability studies

geometric nonlinearity is one of the most important topics and the large deformation makes the corresponding problems difficult to be solved in this paper the imls method based on a nonsingular weight function is applied to obtain the approximation function the penalty method is applied to impose the displacement boundary condition and galerkin weak form of viscoelastic large deformation problems based on total lagrange formulation is used to form the final equations which is solved by the newtonraphson iteration method then the improved elementfree galerkin iefg method based on a nonsingular weight function for viscoelastic large deformation problems is presented numerical examples show that the iefg method in this paper has high computational efficiency the paper can be accepted for publication some suggestions are as follows the english

this paper compares serum ht levels in two groups of patients as well as serum ht levels and psychological rehabilitation levels in patients with different critical mental disorders but there are some problems in the paperthe content of the introduction section lacks a conclusion which is incomplete and the author is invited to add itthe authors should add the summary and highlights of this work in related work to enhance the logic of such workthis article mentions multicomponent exercise multicomponent exercise is one of the best ways to improve patients gait balance cardiorespiratory function and cognitive executive function then i personally feel that this is not detailed enough please ask the author to addin figure the sum of the data set before and after the motion increases with

this study investigated the antiferoptotic effect and molecular mechanism of saa using primary rat cortical neurons and the ich rat model based on this it is a study result predicting that saa is involved in the aktgsk nrf pathway through a pharmacological docking network and induces a protective effect against ferroptosisthe manuscript is fairly well written and includes a great deal of information the results and discussion are represented logically however the following suggestion should be carried out before the acceptance it is unclear how many animals were included in the study and how many were utilized in each group p values and n numbers would be helpful in the abstractfigure experimental design diagram must be included in the manuscript in the current study saa was injected intraperitoneally

the flight control system is one of the key systems to ensure the safe reliable and effective completion of complex tacticalstrategic tasks in uav flight the modal and stability analysis of the system is carried out by linearizing the longitudinal and lateral decoupling models aiming at the flight environment of small uavs the model uncertainty expression method and external disturbance model are determined the flight control law design problem is transformed into a standard h control problem and a robust flight controller is designed through the selection of the weight function matrix to perform linear and nonlinear model simulation the following points area it is difficult to meet the flight quality specifications within the entire flight envelope only by aerodynamic layout and structural design require the meaning of

abstract is short try to define the problem initially in brief as you have directly described your approach literature review section is missing in the script in section explain figures ie concerning robot design perspective in section three types of algorithams are defined but how they are working together that part is missing in the section i think in the results analysis part is missing typos and grammatical errors need to be corrected

this paper has room for improvement that needs the following comments to be addressedhow the proposed big data analysis based prediction model is likely to be enhanced for the prediction of other diseases as well preferably with expected level of accuracy and precision ratio infection rate is among the important measure to evaluated performance of the proposed scheme which infection rate is considered in this paperfor experimental study and observations how many nurses or their data is used in this model additionally how patients are selected moreover experimental results of the proposed model in term of various performance metrics should be compared with existing state of the art methodsproposed method and it various step should be highlighted to the readers along with possible observations which were perceived during

based on a multisource data fusion framework constructed from seabed geomorphology this paper draws a conclusion through experimental research that both bicubic spline interpolation soil tension spline interpolation need to subsample datadense areas which will lead to the loss of detail information in highresolution data in the gridding process all water depth values in the original map are standard water depth and rms values of dem data set are calculated without interpolation early research content of this article is realistic that operable and the article selection belongs to the european hot issue now some suggestions are put forward for this article please refer to the revisiona please explain what the function and formula in the article isb please disclose what data we can get in light of the

sodium aescinate was encapsulated by solid lipid nanoparticles and had good antiinflammatory activity however there are still great hidden dangers in this study which requires the author to carefully modify the manuscript here are some suggestions the author should be more deeply discussed against the antiinflammatory effect mechanism of sevenleaves sodium solid lipid nanoparticles there are some abbreviations in the article without full names please supplement them the discussion is too simple the author only re describes the results in the discussion please increase the comparison with other studies please supplement the instruments and reagent sources mentioned in the manuscript please specify the execution method of mice if it involves the use of anesthetics please measure it please unify the abbreviations in the article and keep the manuscript

in the introduction the author should add his own views appropriately and combine his own content to write paving the way for the followingthe application of the writers corpus helps to improve the translators crosscultural awareness crosscultural awareness refers to the participants sensitive cognition of cultural factors in crosscultural communication which is usually divided into four levels the author can complete this partafter describing the function of bilingual corpus the author should summarize the content of this part beginning and ending so that each paragraph can be read completelythe author writes the whole article around translation at the beginning of the conclusion we should emphasize the importance of translation and echo with the content of the articlethe conclusion part is the summary of the whole article the author

abstract before you proceed to the primary objective of the study you may have two statements that highlight the significance of the study why is there a need to conduct the study you may also focus on the quality of life of the elderly make sure that what you are going to include has a great relevance to your study the primary objective of your study is too long why not focus on the purpose of this study is to understand the effects of depression and sleep quality on the quality of life of the elderly remove to have the correct understanding the study was conducted from juneaugust and the instruments were given to the elderly people living in one of the cities in korea highlight how did

this study to analyze the laboratory indicators that might diagnose femoral head necrosis and provide guidance for clinical prevention based on it this paper finds the patients with femoral head necrosis are related to various factors such as coagulation dysfunction lipid metabolic disorders and inflammation however because the control group and case group have basic diseases and cannot be discharged it is necessary to further apply animal experiments to further study the specific laboratory hazard indicators to help the early diagnosis of femoral head necrosis my advice to the author is as follows make sure all figures and tables are referenced in the text there are many grammatical issues in the article and it is recommended to revise them carefully patients with mental abnormalities or altered consciousness were

the manuscript is well written and provides novel information the authors have showed the therapeutic potential of mir in os via sirt gene i suggest the below revisions before the manuscript can be acceptedin introduction please state why this study was neededwhat concentration of constructs was used for transfectioninformation about primers used is necessary please provide itmtt and other abbreviation should be used in fullinformation of primary and secondary antibodies must be providedplease write the fold decrease of expression of mir in os cells in results sectionproofread the manuscript carefully

trace element concentrations are inextricably linked to the formation of gallstones and abnormally elevated levels provide the conditions for the appearance of gallstones why it is strongly suggested to strengthen the analysis of the effects mechanisms and advantages of these indicators the credibility of the results of this study should be justified in relation to the impact of the relevant effect indicators the shortcomings of this experiment etc in the discussionthe traditional treatment should be applied and discussed in the present study

list the ways you start and explain the problem statement and its solution was good for methods and module design was good for proposed solution the result and discussion session was discussed well with small sample size of data performance evaluation kept good minor issuessample length of data item in table of attributes access structure attributes number of system examples and its limitations with cost should increase and compare of existing methodsexperiments with more samples are need to be strengthen citations need to verify in background section limitation need to clearly mention reference section need to verify with journal format

unfortunately this is not an acceptable study for publication there really is no algorithm presented as stated in the title the manuscript is entirely too long and much of it can be completely eliminated especially the portions that are like a dictated operative report the techniques used are already well established and there is nothing innovative nor new about them even the patient reported outcome studies do not report any significance values so we assume that the before and after values were not significantly different very few skin sparing mastectomy cases were done over a long period of time i dont think there is anything of value in this paper that warrants publication in the breast journal

although the paper is interesting it is hard to read and follow the language of the manuscript must be improved the adopted approach in this work is not clear please describe in detail the literature review is not sufficient i suggest authors to put down more related works there is no conclusion in the manuscript will there be a conclusion for this work the motivation of this work is not clear the authors should describe in detail

in this paper the knnsvm model is established to analyze the annual financial statement results published for listed companies and responds to the prediction results of the model whether there is fraud or not is judged it is a topic of interest to the researchers in the related areas but each paper needs very significant improvement before preparation for publication my detailed comments are as follows in introduction support vector machine is chosen to develop a fraud prediction model unfortunately the reason for choosing support vector machine is missing please add later in section the research direction of this paper is financial fraud prediction model based on regression analysis however the accuracy of neural network prediction model is higher so why not define neural system prediction model to

what the main motive behind this work need more explanationin this section the materials are presented for analyzing and diagnosis of the microscopic blood sample dataset for early detection of white blood cell diseases as described in figure a dataset containing four types of white blood cell diseases was collected all images have undergone an image optimization process to remove noise and all artifacts the optimized images were then passed through to three types of artificial intelligencein this part need proofreading therefore due to the lack of image and low importance we will focus on the other four types in our work increased neutrophil cells in the blood due to bacteria endotoxin exotoxin and fungi the lymphocyte cells increase due to diseases such as hepatitis whooping cough viruses

in the introduction there exist some multiindex or comprehensive evaluation methods for important node identification in complex networks therefore the summarization in the second paragraph is inaccurate the motivation and contributions of this study should be presentedin section the existing studies referring to transportation networks such as urban rail transit networks subway networks etc have been presented however the related work is inadequate focusing on this study some key node identification methods should be analyzed and the existing studies referring to the uav networks should be summarized moreover the last paragraph in this section should be moved to section section is not a system model which refers to the network construction and three general characteristics it is better to integrate it into section in section the interference scenarios

here the authors have done the work on disease like cardiovascular diseases cvds in chronic obstructive pulmonary disease copd patients and construct a prediction model based on these predictors some suggestions need to follow here abstract is too lengthy with values its not clear understanding values can be provided in the results part when you are discussing introduction is not enough of this field please elaborate to refer the relevant paper of this titleenhancement of detection of diabetic retinopathy using harris hawks optimization with deep learning modelan efficient classification of neonates cry using extreme gradient boostingassisted groupedsupportvector networkfigure can be redrawn by using the effective tools professionallyplease provide the proposed architecture before result partconclusion is not enough to say about your achievement and add future work alsothe strengths

paper is nicely drafted but i have the following recommendations the paper has several typos authors need to proofread the paper to eliminate all of themthe word our should not be used in a research paper as it is too informal the pronoun we is used too many times in the paper generally we is appropriate to discuss future work in the conclusion but besides that it should be used sparingly the text of some figures is too small authors should make sure that the text can be read if printed on paperthere are many irrelevant references authors should remove them to keep those that are closely related to the topic of the paperthe authors need to better explain the context of this research including why the research

with the development of geothermal energy in china the exploration of dry hot rock has made breakthroughs and the realization of efficient development of dry hot rock has become a focus of attention the systematic study of rock mechanics and seepage characteristics of dry hot rock has become a key research topic in this paper the physical characteristics mechanical parameters and seepage characteristics of rock experiments are carried out to study the effects of different depths and temperatures on the mechanical parameters and seepage characteristics of granite the results show that with the increase of confining pressure the strength of granite rock increases after high temperature treatment complex fracture network is formed in granite with the increase of temperature the permeability and porosity of granite increase continuously and

this paper proposes a load balancing scheme namely tam to meet the performance requirements of data center long and short flows simultaneously in detail tam leverages the trafficaware ecn marking mechanism to force long flows to proactively maintain the switch queue length at a low level and release bandwidth to short flows when they compete with the bandwidth of the bottleneck link besides by realtime perceiving path status tam carries out the coarsegrained routing and rerouting for short and long flows respectively in this way the short flows achieve low delay transmission while the long flows obtain high throughput the simulation results reveal that tam effectively improves the flowlevel transmission performances for both short and long flows compared to the stateoftheart datacenter load balancing schemes overall the paper

in this paper integrated grid based network coupling model is used to predict the architecture of construction engineering management the coupling model is compared with other models and the interface is evaluated by numerical classification accuracy acc recall rec and f values through several groups of experiments the limitations and advantages of the proposed cnnsae vmdconvlstm model in prediction performance are verified this paper has clear thinking and good prediction effect i check there are still several problems that need to be considered by the author the specific problems are as to whether such introduction needs to be streamlined please consider it by the author please check the subscript of the parameters in the article please explain whether cnn and convlstm models are used repeatedly in this study

dear editor the problem definitions and the approach of dealing solutions are based on ordinary problem concepts using general criteria so analysis is not to be complicated before elaborated by modern techniques ie modern artificial neural network optimization algorithms to get some new results commentsthe manuscript formatting should be regarding shock and vibration principles so it should be revised again especially regarding the author affiliations the title is general and does merely indicates specific specifications and metrics of the research it should be reconsidered to get the ultimate meaning of the researchthe abstract itself was not well organized and needs to be revised again to take the introduction methodology and conclusion quantitively not qualitatively only more quantitative results must be reflected in the abstract the finite element model

this paper studies the dance motion capture technology for visualization needs this is a topic of interest to researchers in related fields but papers require very significant improvements to be accepted for publication my detailed review is as follows i hope to modify the grammar in the article to ensure the readability and correctness of the article section of the article mentions the display system please explain it in detail should as shown in figure in article be changed to as shown in figure please explain the motion pose analysis mentioned in section in detail so that readers can understand it is recommended to adjust its paragraphs to highlight the main points because the first part of the article is too long the combination of motion capture technology

title cystine adsorption on cu cluster a dft studyin this article in this paper dft method was used to get better insight about the binding mode between cystine and metal cluster the manuscript appears to be mathematically correct and the utilized methods and the proposed models are interesting i recommend the paper for publication however there are some concerns comments and suggestion should be addressed before publication in abstract nbo and fmo should mention their full word the purpose of the research and also its application is ambiguous it should be explained in the introduction and abstract check whole manuscript and correct all typos for example the implicit solvent models solvation model based on density under the result and discussion section should be subnumbered specify the properties of

comments to authors lilsx is not a novel adsorbent separation of nitrogen and oxygen from air by adsorption is also not a novel process what is the novelty behind this work a representation of lmin should be followed throughout the manuscript it is flowrate not flow rate please check throughout the manuscript notations for p f and h should be predefined before using them this work may be beneficial at the peak of covid subheading to introduction section is not recommended introduction is concise and informative novelty statement and objectives are missing at the end of introduction check the manuscript for typographical errors the representation of units should be checked throughout the manuscript procedure line provide unit for temperature pressure at and bar were not reported in the

in this paper a finite element analysis model based on mri data is proposed the humancomputer interaction is realized through the elements of situational awareness to train and predict the users information state for many times knee cartilage is modeled on a poroelastic panel by finite volume approach to study social interaction between the fluid and solid matrix of the meniscus under loading conditions the research value is very high but there are some small errors in the research and analysis that need to be revised also ensure the truth of the articlea according to the results of this paper with the increase around load the peak stress value of knee cartilage and meniscus also increased continuously through the process of getting results be supplementedb mri imaging techniques

this paper focus s the social entity recommendation in social networks which is a hot problem in the field of recommendation this paper investigates the joint recommendation model in social social media medical big health information tagging and grouping information on deep multitask learning proposed from a new perspective that the paper is already organized and the test results are helpful so i recommend this paper be accepted

the project is based on the completed highway tunnels in inner mongolia in view of a series of special problems faced by the construction and management of tunnels in cold regions a large number of reference documents have been consulted we designed the thermal insulation antifreeze and antidrainage technology for tunnels in the cold area of jinpen bay few comments are as how do you understand tunnel seepage what is the situation of tunnel freezing injury in cold regions of china analyze the design status of thermal insulation layer of tunnel engineering in cold regions abroad need to check the english correction because and because most of the northeast china is a seasonally frozen area the temperature change in the seasonally frozen area especially the cold working conditions

abstract statements include more content on all main achievements of the study develop the literature review process the conceptual model section needs to be improved the research objectives and methodology is unclear and should receive better explained and motivated the research findings and methodology should be better explained und motivated the results and analysis section is overall should be better analyzed and developed further and in the optimum situation within the current situation develop the conclusions section to promote the unique contributions of the paper theoretical and managerial implications limitations of the research could be added authors should debate their limitations in detail correctly in the conclusion section the authors have not discussed the advantages of the proposed model

comment some details can be removed in the abstract such as leuprorelin and norethindronecomment in between the abstract and clarity instead of saying at baseline it is clearer to directly say before or after surgerycomment in this first tier of the discussion this result is close to other studies i think it is better to use similar terms instead of close tocomment in the third paragraph of the section the prognosis a value should be the prognostic predictive valuecomment the analyses were a bit too simple if possible the authors may consider to use the data to do more clearly there are some grammar errors in the manuscript can improve the image

one study to retrospectively analyze apatinib combined with nabpaclitaxel efficacy and safety in secondline treatment of advanced gastric cancer agc this paper finds apatinib combined to nabpaclitaxel is safe and effective in the secondline agc treatment and chemical reactions are tolerable my advice to the author is as above the results page only contains relevant data and does not provide a detailed description of its results and it is recommended that the authors add an analysis on the relevant results the exists many grammatical issues in the article and it is recommended to revise them carefully all patients in this study were complete or not and patients with insufficient clinical data were not included in this study whether there were patients who dropped out of the study in

ai noticed many subsections of the abstract section in this article please remove them because the abstract section should be clear and concise if this is not possible then improve the abstract section moreborganize your work according to the journals guidelinescin the opening section define the papers main sectionsdplease correct this works grammatical and typographical faultseplease make the necessary changes to the cited style of the references in the paper bodyfthis sentence has some grammatical errors please remove the error carefully not only sexual activity but also other aspects of life pattern are also simple and relatively uniform among this population compared with those out of campusgtable appears to have some inaccuracies please correct them and recalculate all of the datahplease condense the discussion portion and slightly expand

i am extremely grateful to the journal for providing me with an opportunity to review a research article overall the paper is wellwritten and presents a novel idea that can be used in various security applications the paper is fit for publication in the security and communication networks however the authors need to address the following comments in the revised version i suggest here some minor changesthe caption assigned to figure in the submitted manuscript is wrong it is advised to change the caption of figure the figure given at the bottom of the page in section methodology has no caption for it it is suggested to add the correct caption for that figure and cite in the textin section ie related work under the heading of image

the research article is wellwritten and served purpose of the studythe aim of this research article is to evaluate the efficacy of pramipexole combined with ganglioside in the treatment of parkinsons disease pd and pramipexole monotherapy so as to provide reference for clinical practice data is wellpresented and the conclusions are adequately supported by the data however manuscript needs some minor changes before acceptance that are explained belowall the abbreviations should be explained when used the first time in the manuscript in addition if you can avoid any of the abbreviations it is preferred to write only full textyour manuscript needs a professional revision for the language you may use any professional service to improve its languagein method the approval no of the hospital ethics committee should be

the article entitled an evaluation of clinical effectiveness relative safety of endoscopic colon stenting in the treatment of obstructive left colon cancer a systematic review and metaanalysis is an interesting study however there are several minor issues should be corrected there are incorrect grammar of spelling mistakes in this article please correctedthe author of the introduction was missingthe figure without tables should been put at the end of the articlethere should be a conclusion part at the end of the referencesome references are too old cheung hy chung cc tsang po et al endolaparoscopic approach vs conventional open surgery in the treatment of obstructing leftsided colon cancer with randomized controlled trial arch surg decfiori e lamazza a schillaci a et del palliative management for patients with subacute obstruction

in this study the authors tried to find the effect of shenhu wendan shwddecoction on the depression of chronic unpredictable mild stress cums rat the scales of the stainings are missing the most concern is that the effect via activating bdnferkcreb signal pathway is not solid usually the knockdown or overexpression is required and more support is needed optogenetic is a technique that combines optics and genetics to control specific neurons applied widely in the animal model of depressiondoi fnagi i suggest the authors also reference this review technique i suggest the authors make the figures of table and

in this paper the clinical manifestations of uterine contractions vary greatly ranging from asymptomatic mild palpitations to syncope or amaurosis and sudden death arrhythmias caused by malignant premature ventricular contractions and their clinical symptoms and prognosis are not parallel but i still have some problems that need to be revised by the authorthe abstract has background objectives methods and results but the final conclusion is missingthe article uses two large paragraphs to introduce premature ventricular contractions and palpitations the content is too much so the author should delete itthe authors were asked to briefly describe clearly the comparison between patients with ventricular premature contractions treated with electroacupuncture and traditional acupuncture and to provide an important summaryin the discussion it is recommended to compare this study with other research

my points of this paper as shown below follow me and improve your paperplease make the basic adjustments to table as low as possibleplease match the style of the last two references to the othersplease emphasize the current state of surgical procedure application and the importance of this studycould you kindly clarify why patients under the age of were not includedthe paper writing is not appreciable work seriously to improve the presentation of the paperthe clinical section particularly the comparison of past research results cannot be improvedfrom its start you cannot specify explicitly what your study will look at an indepth overview of the subject should be the first part of an introductionit is vital that you define the scope of your questions from the start your introduction

ideological and political education in colleges and universities adheres to the peopleoriented principle and carries out allround education for college students from the fundamental task of cultivating people by virtue nowadays restricted by many aspects such as family and society college students hearts are becoming more and more sensitive how to eliminate or avoid the psychological confusion psychological crisis and psychological barriers caused by the daily problems of study life emotion and interpersonal communication has gradually become an issue that universities pay close attention to the research results of this paper have important practical significance but there are still the following problems influence on parents and childrens mental health education how to understand the imperfection of psychological crisis management system what affects the mental health of college students

based on the theory of environmental credit and the characteristic advantages of neural network this paper constructs an evaluation model of eeb based on neural network which includes six qualitative evaluation indexes of waste disposal noise at factory boundary illegal sewage discharge environmental punishment environmental pollution complaint and handling and internal environmental management of enterprises and quantitative evaluation indexes while according to the credit score interval four corporate environmental behavior credit grades are divided however there are also some problems some revisions needed to be revised to make sure that the manuscript can be accepted the commonly problems are as follows there are also some problems in language expression in this paper which need to be modified please check the chinese characters in the replacement formula and the

from january to december patients with colorectal cancer who were not diagnosed after surgery in the department of general surgery in xiamen chinese medical system were included in this study the pathological parameters including gender age pathological stage depth of tumor invasion lymph tumor metastasis distant metastasis etc were recorded the major cancer tissues of cancerous tissues of the resected malignant tumor tissues were collected qpcr and western blotting is used to measure relative quantity and protein levels of ki and sox immunohistochemistry was used to detect the correlation between ki and sox protein expression and clinicopathological parameters in colorectal cancer in the opinion of the reviewer the paper is technically interesting unfortunately there are several major issues which must be corrected and improved to its authors in

with order to explore the role of structural performance in earthquake mitigation and prediction human beings need to accurately evaluate the residual mechanical properties of civil engineering columns after earthquake load based on our intelligence the parameter optimization evaluation and application in seismic damage of reinforced concrete columns are carried out in this paper through experimental simulation some model can extract the appearance damage and component parameters according to realtime images fully express the postearthquake situation of columns and ensure objectivity and authenticity compared for other models the performance of this model has been greatly improved and the predicted distribution appears very close to the expected value some suggestions are fast forward for the content of the article please refer to the revisiona the website of the website

i recommend to the authors please rewrite the reverse population equation correctly it has some minor errorfigures and are horizontal whereas the other two are vertical is it feasible to verticalize figures and add some more references to the list of references given in the introductionin equation the authors use pi but the value of the pi is not defined resolve the issuesome of the words of the figure are incorrectly written please resolve the issuerevise the following sentence correctly as demonstrated in the data in the figure as the training progresses the network loss gradually decreases and finally tends to convergebecause the presentation of the article is so bad an improved presentation will be greatly appreciatedwhat are experiments please provide some information about themthe language in the

this paper is one of the first efforts to develop an intelligent edge ran architecture and a labscale testbed supporting all of the architectures major features i can find the practical significance of the research from many aspectshowever here are some comments to further improve the paper there are some english writing problems please consider additional proofreading there is no detailed experimental hardware configuration information and the network environment of the laboratory please provide more information in the paper to explain it please update the list of references and unify format for this hotspot research the references in the last three years may be more valuable

collaborative filtering recommendation is an important and interesting problem in the case of extremely sparse data this work proposes to combine random slope matrix prefilling by principal component reduction and binary kmeans clustering for collaborative filtering recommendation in this the proposed method establishes a relatively perfect sampling system and reduces the dimension of the prefilled score measured by principal component analysis and ensures the success and accuracy of the collaborative filtering recommendation algorithm by binary kmeans clustering the idea is interesting and incremental enough for this topic and the technique line is reasonable the experimental results show that the proposed method is superior to the traditional collaborative filtering algorithm and validate the effectiveness even in the case of sparse data doing this like the well organized and the

important people for inviting me to evaluate this manuscript this is a novel and mature article it has attention to the puerpera and solves this problem well you only need it fix a few minor issues and you can publish practically any problems in the abstract part at the beginning of any article the content level is not clear enough the logic is not specific enough and the content is simply stacked also the number of keywords listed in the article is too high the list of keywords should be five or six please further explain the experimental method in the article which is not seen in the corresponding part of the article and then compare and analyze research methods this paragraph has some problems in the presentation

the experimental results show that the abp algorithm designed in this paper reduces the training error by compared with the traditional bp algorithm it shows that the abp algorithm has good performance in realtime collection of big data in logistics supply chain and the delay of the system designed in this paper is less than ms and the response time is less than s indicating that the system can run stably such experimental results are very satisfactory but there are some problems in other aspects of the paper that need attentiona the collection of logistics supply chain data in this article uses rfid technology and barcode technology for realtime collection but the author did not introduce rfid technology please addb wireless sensor network consists of hardware platform operating

this is a very interesting manuscript worthy of publication the results of the study and the expression of the manuscript are satisfactory which has important reference significance for the analysis and prognosis of lung adenocarcinoma but for the benefit of the readers there are still some problems with the manuscriptrationale of the study the authors should better clarify their working hypothesis it is clear that the authors are not experts of the themethe author has selected very representative bioinformatics database information then what about other useful database information sources did you look at other studies please do not comment on research results without significant differences do not engage in irrelevant comparisons and discussions and reduce some inappropriate speculation there are some formatting problems in the reference section of

the authors newly identifiedthe application mechanism of tumor stem cell vaccine brucea javanica oil combined with nkga inhibitor in bladder cancer and the effect on loxl i would be very glad to review the paper in greater depth once it has been edited because the subject is interesting but there are some mistakes and shortage in the manuscript as followingline the abbreviation of highly heterogeneous tumor hepatocytes is csc please correctplease indicate the formula for calculating tumor volume in the articleplease added the cell concentration inoculated when establishing the mouse tumor modelplease indicate the inoculation concentration of cancer stem cell vaccinesome reagent company do not display please added

the language needs major modifications the authors should avoid long sentences also revise the manuscript and remove all the grammatical typo punctuation and other errorsthe introduction part of the paper needs to be modified and provide an overall organization of the paper enhancing the description part so as to include different overall nature of the paper in a more elaborate mannerdiscuss the significance of cellular internet of things on a communication networkcheck citation and formatting of the reference some citations require improvement also check the formatting before the paper before processing this articlegive some details of progress in a more effective way modification is required in the result and discussion section add a discussion to the proposed research

in this paper the authors investigated the influences of gata mutations in breast cancer progression the followings are the few suggestions which may be included while revisionambiguous statement ie many efforts have been made to study the influence of these mutations on tumor progressionthe important and newest references should be added in the discussion section ie gata truncation mutants alter emt related gene expression via partial motif recognition in luminal breast cancer cellsthe quality of english needs improving

this study examines the use of the wechat app in the continuity of care of breast cancer patients the use of wechat in the continuum of care can improve the physical socialfamily emotional and functional status of breast cancer patients which in turn improves their quality of life wechat interventions are superior to conventional continuous care in improving outcomes after breast cancer surgery overall it is a useful research based on clinical guideline however there are some comments as follow there are some grammatical errors in the article abstract section for example it should be attitudes not attitude consultations not consultation the abstract section is too long there exhibited many no significant results in this sectioni suggest author to summarize this part in the introduction part several words

aare you able to provide a clear definition of simulation experiment analysisbi suggest that the authors accurately write equation and cthe figures and tables citation styles are inconsistent kindly fix this dthe conclusion section is extensive and falls short of providing a complete summary of the paper sketch please improve it a littleethe reference format varies from one source to the next it must be outlined and cited in the textfwhat is the purpose of the gateway design in this textgthe nd sentence of the abstract section is unclear please clear themhthe studys material must be thoroughly checked for mistakes and linguistic problems before comments may be submitted

areferences and have a different function please make the style of all reference references be consistentbit can be found from to that when the system is added to the nonlinear controller the state changes from an unstable state to a stable state with the same parameter and the initial value and the unstable subcritical bifurcation phenomenon does not occur indicating that the given nonlinear controller has a good control effect and changes the motion state at the critical point revise in gamma value carefullycwork on this section a little more bifurcation characteristic analysis of directly coupled system carefullydimprove all of the details in the method sectionethere are a set of grammatical mistakes examine it carefullyfsome of the equations are wrongly written review them will solve the problemgthe presentation

through several indicators introduced in this article there are new ideas for symptom evaluation of mm patients which can bring great help to doctors it seems that the proposed algorithm works well from the simulation resultsi think this paper is very interesthowever there are still some major problems i recommend that this paper can be accepted after major revision the comments are as followsas for the discussion way of the abstract part it is suggested to modify it into a normal way of discussion because the point description will make the focus of the abstract not prominent enoughthe introduction language of mm patients is too redundant it can be combined with examples in daily life to make the language and words more distinctas for the charts in the

with the development of modern medicine the application of deep learning in medically assisted diagnosis can greatly improve the diagnostic accuracy of diseases so as to become a research starting spot on the field of medical information based on the characteristics of retinal vascular images this paper proposes a vascular image segmentation method based on bfcn deep network the paper has clear roots in argumentation and full content thus carries certain value in the diagnosis of ophthalmic diseases however and research depth of this paper needs to be improved and there are still several problems which need also be modified please refine the abstract again such as adding some data in the conclusion part so as to make the abstract more convincing for the previous part consider the

reveiwermention magnetic resonance imaging as an assistive device mri in the medical fieldexplain the importance of the sun flower optimized algorithm sfoa in this presented workwhich algorithm is used for the feature extraction proceduremention the main concept of the convolutional neural networkresearch originality and contribution need to be enhanced justifications are necessary to verify the significance of the studythe future scope of enhancement can be included in the conclusion section

in this work the author proposed a framework for retinal vessel segmentation overall the paper is well written however i have following concerns the authors need to considerthe significance of the work is not clear the importance of the work should be mentionedthe authors need to highlight what are the gaps left by previous approaches and how proposed framework filled those gapsrelated work is very limited the authors need to include more related current literaturethe authors need to mention how the proposed network is different from traditional unetfurthermore following references are similar to the proposed framework the authors need to discuss the difference between proposed and the following frameworksaan encoderdecoder deep learning framework for building footprints extraction from aerial imagery arabian journal for science and engineering ppbdeep hybrid