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biomedical-topic-categorization-validation

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cyclic amino barrelen carben origin famili caac novel synthet pathway novel famili cyclic alkyl amino carben name cyclic amino barrelen carben cabc report key synthet step involv intramolecular cyclize anthracen deriv alkyn synthet approach allow attach aryl alkyl group nitrogen atom use ligand two barrelen hydrogen close contact metal could stabil low valent catalyt intermedi

D000480;D008697

T109

infer characterist bacteri swim biofilm matrix time laps confoc laser scan microscopi biofilm spatial organ communiti microorgan embed self produc organ matrix confer popul emerg properti increas toler action antimicrobi shown bacilli abl swim exogen matrix pathogen biofilm counterbal properti swim bacteria deliv antimicrobi agent situ potenti activ antimicrobi creat transient vascular network matrix henc character swimmer trajectori biofilm matrix particular interest understand optim new biocontrol strategi particular also general deciph ecolog driver popul spatial structur natur biofilm ecosystem studi new methodolog develop analyz time laps confoc laser scan imag describ compar swim trajectori bacilli swimmer popul adapt biofilm structur method base infer kinet model swimmer popul includ mechanist interact host biofilm valid synthet data methodolog implement imag three differ speci motil bacillus speci swim staphylococcus aureus biofilm fit model allow stratifi swimmer popul swim behavior provid insight mechan deploy micro swimmer adapt swim trait biofilm matrix

D000077317;D013550

T056;T123

function abnorm cerebello thalam pathway mous model dyt dystonia dystonia often associ function alter cerebello thalam pathway propos contribut disord propag patholog fire pattern forebrain examin function cerebello thalam pathway model dyt dystonia dyt gnal mice carri heterozyg knockout mutat gnal gene notabl disrupt striatal function system striatal administr oxotremorin mice trigger dyston symptom result reveal increas cerebello thalam excit presymptomat state follow first dyston episod gnal mice asymptomat state exhibit increas cerebello thalamo cortic excit maintain burst stimul cerebellum administ symptomat state induc cholinerg activ stimul decreas cerebello thalam excit reduc dyston symptom agreement dystonia multiregion circuit disord result suggest increas cerebello thalam excit constitut earli endophenotyp cerebellum gateway correct therapi via depress cerebello thalam pathway

D004421;D020821

T047;T184;T048

decod activ stem cell phenotyp neonat matur pituitari pituitari repres endocrin master regul mous gland undergo activ matur immedi birth detail portray stem cell compart neonat pituitari singl cell rna sequenc pictur activ gland reveal prolif stem well hormon progenitor cell popul stem cell pool display hybrid epithelialmesenchym phenotyp characterist develop involv tissu stem cell organoid cultur recapitul stem cell phenotyp interest also reproduc paracrin activ pituitari stem cell activ interleukin advanc organoid growth although neonat stem cell compart visibl affect il mice like due cytokin famili redund transcriptom analysi expos pronounc wnt pathway neonat gland shown involv stem cell activ overlap fetal human pituitari transcriptom follow local damag neonat gland effici regener despit absenc addit stem cell prolifer upregul il wnt express line alreadi high stem cell activ status therebi expos strike differ adult pituitari togeth studi decod stem cell compart neonat pituitari expos activ state matur gland understand stem cell activ key potenti pituitari regen prospect

D010902;D013234

T023;T025;T081

fucoidan base hydrogel particl versatil carrier diabet treatment strategi current lack fulli effici therapi diabet mellitus chronic diseas metabol blood glucos sever hinder deficit insulin cell resist hormon therefor crucial develop new therapeut strategi treat diseas includ devic control deliveri insulin encapsul insulin produc cell work fucoidan fu marin sulfat polysaccharid exhibit relev properti reduc blood glucos antioxid anti inflammatori effect use develop versatil carrier envisag diabet advanc therapi fu function methacryl mfu use vv methacryl anhydrid photocrosslink use visibl light presenc triethanolamin eosin produc hydrogel particl degre methacryl vari determin hnmr produc particl averag diamet rang mm dri state insulin ad mfu solut produc drug load particl releas profil assess phosphat buffer solut pbs simul intestin fluid sif h insulin releas sustain manner initi h reach plateau higher pbs sif indic lower ph favor drug liber moreov abil mfu particl serv templat cultur human pancreat cell assess use b cell line day cultur period studi pancreat beta cell prolifer global viabil tend form pseudo islet thus suggest propos biomateri could good candid versatil carrier diabet treatment sustain releas insulin support pancreat beta cell viabil

D003920;D020100

T047;T122

progress modern reproduct biolog research china reproduct biolog close associ human health social progress modern reproduct biolog research china began advanc scienc technolog govern support intern collabor spawn rapid growth reproduct biolog research china develop reproduct biolog provid theoret knowledg applic technolog also generat new social ethic concern review summar highlight contribut modern reproduct biolog research china specif focus aspect relat human reproduct health

D001695;D012098

T091;T081;T040;T079

empir deposit correl tradit empir correl predict respiratori tract deposit inhal aerosol develop use limit avail vivo data recent advanc medic imag segment addit manufactur process allow research conduct extens vitro deposit experi realist replica upper central branch airway work led collect empir equat predict region aerosol deposit especi upper nasal oral airway present section review empir correl base vivo vitro data may use predict total region deposit equat present predict total respiratori deposit fraction mouth throat fraction nasal nose throat fraction larg varieti aerosol size subject age group breath maneuv use correl estim total lung deposit also describ

D008168;D010614

T023

distinct neural respons morning evening chronotyp homeostat sleep pressur reveal rest state function magnet reson imag chronotyp appropri variabl investig sleep homeostat circadian rhythm base function mri rest state function connect rsfc insula angular decreas increas homeostat sleep pressur hsp howev distinct neural respons differ chronotyp remain clarifi therefor investig hsp influenc insular angular neural interact differ chronotyp

D002940;D012890

T040;T033

dehydrogen invers electron demand diel alder reaction synthesi function pyranon effici dehydrogen invers electron demand diel alder reaction isopropyl prenyl benzen deriv electron defici dien follow decarboxyl report first time much broader substrat scope dienophil electron defici dien led biolog valuabl pyranon good excel yield

D004583

T196;T081

advanc develop molecular target therapi hepatocellular carcinoma hepatocellular carcinoma hcc one common malign tumor china sever threaten life health patient recent year precis medicin clinic diagnos treatment innov research led import breakthrough hcc care discoveri new biomark promot liquid biopsi technolog great facilit earli diagnosi treatment hcc progress target therapi immunotherapi provid choic precis hcc treatment multiom technolog genom transcriptom metabolom enabl deeper understand occurr develop mechan heterogen genet mutat characterist hcc continu promot accur type hcc accur guidanc treatment accur prognost provid treatment opportun prolong surviv timelin patient hcc innov hcc research provid depth understand biolog characterist hcc translat accur clinic practic diagnosi treatment hcc

D006528;D008113

T191

synthesi new pyrimidin triazol deriv investig anticanc activ aromatas inhibitor use anticanc drug group breast cancer case develop resist cancer patient time side effect exist drug make need new effect agent perman studi novel pyrimidin triazol deriv synthes anticanc activ investig compound c g show inhibitor activ mcf cell line ic valu respect result vitro aromatas enzym inhibit test compound c g exhibit signific activ ic ic respect estim physicochem paramet calcul use onlin swissadm program compound interact mode compound c g investig aromatas enzym mean dock studi result studi import triazol ring aromatas inhibit understood

D000970;D001141

T121;T109;T126;T116

pattern diseas relaps posttreat follow patient resect pancreat adenocarcinoma singl center analysi describ pattern diseas relaps follow patient resect pancreat adenocarcinoma addit look patient characterist relaps surviv

D000230;D010190

T191

microplast profus food drink water microplast becom macroproblem microplast extrem complex food chain come full circl dread could deleteri influenc human although risk plastic human yet establish occurr food water destin human consumpt report preval micro size plastic ecosystem live organ trophic transfer along food web discern food speci compet indic becom research prioriti scale issu massiv main culprit caus could solut sight global problem despit massiv amount research field collat avail data pertin hazard evalu remain difficult order identifi knowledg gap exposur pathway sever trait relat food chain assess present goal proper evalu manag emerg risk apprehend three possibl noxious consequ small plastic particl first due plastic particl second due extric tenaci organ pollut adsorb onto plastic third due leach compon monom addit plastic exig standard protocol bring consist data collect analysi involv solut stakehold cost benefit discuss harmon method enabl meticul assess impact threat microplast pose biota increas compar studi emphas contribut honest broker scienc provid overarch analysi devis viabl solut microplast pollut privat public leadership util

D060766;D014874

T167;T131

valid multipolar puls field ablat cathet endpoint assess pulmonari vein isol procedur valid perform multipolar puls field ablat pfa cathet compar standard pentasplin map cathet endpoint assess pulmonari vein isol pvi pfa pvi use singl shot devic combin benefit high procedur efficaci safeti newli avail multipolar pfa cathet allow real time record pulmonari vein pv signal pvi

D001281;D017115;D011667

T061;T047;T046;T023

radiograph cutoff valu predict later boni imping progress collaps foot deform later boni imping major caus later foot pain progress collaps foot deform pcfd weightbear comput tomographi wbct provid better sensit standard radiograph detect imping howev mani orthopaed center yet acquir wbct imag studi aim investig correl common radiograph paramet measur standard weightbear radiograph talocalcan calcaneofibular distanc assess wbct establish radiograph cutoff valu detect boni imping identifi wbct

D002111;D005413;D005530;D005534

T023;T190;T019;T047

amcp partnership forum evolv role digit therapeut digit health tool specif digit therapeut dtx primarili use prevent manag treat medic condit pose challeng opportun health care system address need relat coverag evalu access dtx amcp held virtual multistakehold forum august septemb group expert conven includ repres payer pharmaci benefit manag integr deliveri system patient advocaci dtx innov organ along individu health economist academician key stakehold particip ask identifi current marketplac challeng area opportun around coverag use dtx provid input assist health care decis maker make coverag decis dtx area opportun identifi particip includ standard product definit categor across dtx industri emphas valu regulatori approv establish standard evid dtx establish evid framework guid coverag reimburs decis dtx consid uniqu dtx product aspect data secur privaci product updat advanc awar profession expertis dtx among health care stakehold promot dtx adopt equit access disclosur connect content ltd receiv payment amcp prepar manuscript dr flavin employe ingeniorx time forum adjunct associ professor univers florida colleg pharmaci dr dharbhamalla report conflict interest employ amcp event sponsor follow akili pear therapeut pfizer phrma simon kucher partner takeda theranica woebot health repres akili pear therapeut pfizer phrma simon kucher partner takeda theranica woebot health join either panelist particip

D010593;D010604

T091;T058;T170;T057

simpl step enabl reproduc cultur condit affect chlamydomona growth element composit even subtl modif growth condit elicit acclim respons affect molecular element makeup organ laboratori natur habitat systemat explor effect temperatur ph nutrient avail cultur densiti access co laboratori grown algal cultur growth rate ionom abil accumul fe found algal cell accumul fe alkalin condit even excess fe present coincid reduc growth rate use combin fe specif dye x ray fluoresc microscopi nanosim show alkalin accumul fe intracellular sequest acidocalcisom local toward peripheri cell high photon flux densiti zn ca specif accumul zn alon accumul low temperatur impact aerat probe reduc shake speed chang vessel fill level former increas cu quota cultur latter result reduct p ca mn low fill level trace element quota also affect stationari phase specif fe cu zn accumul cu accumul depend invers fe concentr medium individu laboratori strain accumul ca p cu differ level togeth identifi set specif chang growth rate element composit capac store fe respons subtl differ cultur condit chlamydomona affect experiment reproduc accord recommend variabl record report associ metadata

D002696;D014131

T121;T123;T002;T196

autom region citrat anticoagul base onlin monitor ioniz calcium concentr proof concept region citrat anticoagul rca complex effect techniqu recommend anticoagul choic continu renal replac therapi one key object keep ioniz calcium target rang studi aim develop autom rca base onlin monitor ioniz calcium concentr close loop feedback

D019343;D002118

T121;T109;T123;T196

quantil base person treatment select multivari outcom multipl treatment work propos method individu treatment select correl multipl respons k treatment k scenario use rank quantil outcom variabl treatment condit patient specif score construct collect covari measur method cover number treatment outcom variabl use number quantil appli broad set model propos rank aggreg techniqu combin sever list rank list element within list correl method flexibl incorpor patient clinician prefer optim treatment decis individu case basi simul studi demonstr perform propos method finit sampl also present illustr use two differ dataset diabet hiv clinic trial show applic propos procedur real data

D057285;D012107

T061;T081;T091;T170;T169;T062;T096

three mode interact anion phenol macrocycl compar studi macrocycl polyphenol compound resorcin aren consid multident anion receptor current work combin new experiment data report previous literatur solut data deposit crystal structur ccdc systemat analyz bind motif resorcin aren deriv anion determin role support interact ch donor ion pair estim relat strength found medium polar solvent thf anion bind main drive forc format complex resorcinaren alk nx salt three bind mode detect use h nmr dosi depend type addit interact mode observ upper rim unsubstitut resorcinaren use oh group aromat ch upper rim hydrogen bond donor form multident multival bind site upper rim mode ii observ upper rim halogen resorcinaren tetrabromo tetraiodo deriv use oh group aliphat ch atom bridg support chelat anion aromat unit bind mode also multident multival weaker anion select mode work effect chlorid bromid substitut deriv mode iii observ anion bound nest form aromat ch atom lower rim multident monoval bind relat strength three bind mode solvent depend emerg crystal structur ccdc evalu

D047028;D010636

T121;T109

potenti microrna biomark therapeut target respiratori virus literatur review microrna mirna small noncod rnas regul gene express recognit cognat sequenc interfer transcript translat epigenet process hundr mirna gene found divers virus mani phylogenet conserv respiratori virus frequent causat agent diseas human signific impact morbid mortal worldwid recent role mirna respiratori viral gene regul well host gene regul diseas progress becom field interest review highlight import various mirna potenti role fight respiratori virus therapeut molecul focus covid

D035683;D012140;D014780

T047;T123;T005;T114

identif gene alter methyl osteoclast differenti role osteoporosi osteoporosi one common metabol skelet diseas affect million peopl worldwid especi elder postmenopaus women one main process osteoporosi attenu bone format abund evid confirm overactiv osteoclast respons attenu bone format studi aim identifi novel methyl associ biomark therapeut target osteoclast integr analyz methyl profil gene express data dna methyl profil gene express data obtain gene express omnibus geo databas subsequ integr two set data screen differenti express gene differenti methyl level dm deg osteoclast cd monocyt donor gene ontolog go analysi kyoto encyclopedia gene genom kegg pathway analysi perform uncov enrich function pathway identifi dm deg addit combin protein protein interact analysi receiv oper characterist analysi final identifi four hub dm deg gene set enrich analysi util valid investig potenti biolog function four hub dm deg final real time quantit pcr qpcr perform valid mrna express level four identifi hub dm deg osteoclast differenti ccrl ccl cqb sell high correl osteoclast differenti osteoporosi phenotyp qpcr reveal express ccrl ccl cqb increas osteoclast differenti wherea express sell decreas present studi indic connect gene express dna methyl osteoclast differenti four hub dm deg osteoclastogenesi osteoporosi pathogenesi might potenti candid intens research therapeut target treatment osteoporosi

D020869;D010024

T059;T047;T063

impact lurasidon health relat qualiti life adult bipolar depress post hoc analysi object post hoc analysi assess impact lurasidon monotherapi health relat qualiti life hrqol adult bipolar depress

D001714;D000069056

T121;T109;T048

exsanguin ruptur femor arteri pseudoaneurysm fatal complic groin heroin inject intraven drug user idus eventu encount common problem need turn new vessel inject drug whether spot avail due scar conveni groin prefer spot chronic punctur femor vessel lead rare signific complic femor arteri pseudoaneurysm fap fatal consequ ruptur bleed well recogn forens literatur subject limit present eight case exsanguin due ruptur fap idus share follow characterist long term heroin use andor pronounc drug use stigmata chronic groin inject relat lesion absenc signific precipit pseudoaneurysm trauma minim concentr heroin metabolit blood fap present vari great palpabl fist size mass slight elev skin defect infundibular arterio cutan fistula ruptur skin indur surround skin soft tissu show sign inflamm without suppur promin fap characterist smooth surfac cavit cross section perform microscop evalu two case verifi disrupt arteri wall ie pseudoaneurysm element acut chronic inflamm fibrosi foci fibrinoid necrosi notic arteri wall subject pale faint hypostasi organ anemia consist report massiv hemorrhag sudden unwit suspici death may rais question injuri inflict proper autopsi evalu crucial propos guidelin

D017541;D015819

T046;T048

erp chaperon protein protect neuron cell induc toxic alzheim diseas ad neurodegen disord whose main patholog hallmark accumul amyloid peptid form senil plaqu caus neurodegener disrupt cognit function sever mechan includ oxid stress erp protein disulfid isomeras involv cellular stress respons known present cerebrospin fluid normal individu complex peptid suggest may carrier protein prevent aggreg although sever studi show erp involv neurodegen diseas clear mechan action identifi thus far work gain insight interact erp special focus contribut erp defens system cell show recombin erp direct interact fragment vitro high affin via two silico predict main site interact furthermor use human neuroblastoma cell show short term treatment induc erp decreas intracellular protein level differ intracellular local erp secret cultur medium final demonstr recombin erp counteract toxic effect restor cellular viabil prevent aggreg overal present studi show extracellular erp exert protect effect toxic highlight possibl therapeut tool treatment ad

D000544;D009474;D010446;D019704

T047;T116;T126;T048;T025

direct measur stall torqu flagellar motor escherichia coli magnet tweezer flagellar motor drive rotat flagellar filament propel swim flagel bacteria maximum torqu motor generat stall torqu key characterist motor function direct measur stall torqu carri decad ago suffer larg experiment uncertainti subsequ indirect measur appli magnet tweezer direct measur stall torqu e coli precis calibr torsion stiff magnet tweezer perform motor resurrect experi stall accomplish precis determin stall torqu per torqu generat unit stator unit measur stator pass proton per step indic tight coupl motor rotat proton flux import maximum torqu bacteri flagellar motor generat stall torqu critic paramet describ motor energet motor oper equilibrium near stall stall torqu one determin mani proton torqu generat unit stator motor pass per revolut test whether motor rotat proton flux tight loos coupl controversi recent year direct measur perform decad ago suffer larg uncertainti subsequ indirect measur attempt obtain rang valu inconsist previous direct measur develop method use magnet tweezer perform motor resurrect experi stall result direct precis measur stall torqu per stator studi resolv previous inconsist provid direct experiment support tight coupl mechan motor rotat proton flux

D004926;D005407;D020409

T007;T026;T123;T116

hda contain complex requir activ catalas express neurospora crassa essenti aerob organ maintain homeostasi intracellular reactiv oxygen speci ros surviv adapt environ line eukaryot catalas neurospora crassa import enzym clear ros express tight regul growth phase various oxid stress studi reveal n crassa histon deacetylas hda catalyt activ posit regul express catalas cat gene hda sif snt may form subcomplex regul role expect delet hda sif subunit increas acetyl level histon h indic loss hda complex fail deacetyl h cat locus furthermor loss hda catalyt activ led dramat decreas tfiib rna polymeras ii rnap ii recruit cat locus also result high deposit haz promot transcript start site tss region cat gene collect studi strong demonstr hda contain complex activ transcript cat gene facilit preiniti complex pic assembl antagon inhibit haz cat locus h acetyl import clearanc reactiv oxygen speci ros critic surviv aerob organ model filament fungus neurospora crassa catalas cat express activ respons h induc ros stress found histon deacetylas hda posit regul cat transcript n crassa wide diverg classic repress role histon deacetylas like hda sif snt subunit hda contain complex play posit role cat transcript furthermor also found hda contain complex provid appropri chromatin environ facilit pic assembl antagon inhibit role haz cat locus h acetyl taken togeth result establish mechan hda contain complex regul transcript cat gene n crassa

D009492

T004

membran tether mucin stimul interferon virus infect multipl cell type inhibit influenza virus infect human airway epithelium influenza virus iav caus signific morbid mortal human popul tether mucin muc high express airway epithelium primari site iav replic also cell type influenc iav infect includ macrophag muc potenti influenc infect dynam physic interact andor signal activ yet muc modul impact viral pathogenesi remain unclear thus investig muc iav interact vitro model human airway epithelium hae data indic recombin iav hemagglutinin h hn virus bind endogen hae muc notabl infect hae hn hn iav strain trigger muc shed instead stimul increas cell associ muc protein observ similar increas type iii interferon ifn stimul howev inhibit ifn signal hn infect partial abrog increas indic multipl solubl factor contribut muc upregul antivir respons addit hae primari human monocyt deriv macrophag also upregul muc protein respons ifn treatment condit media iav infect hae determin impact muc iav pathogenesi develop hae genet deplet muc found muc knockout cultur exhibit enhanc viral growth compar control cultur sever iav strain togeth data support model wherebi muc inhibit product uptak iav hae infect stimul muc express multipl cell type ifn depend independ mechan impact infect dynam import influenza virus iav target airway epitheli cell infect larg heavili glycosyl molecul known tether mucin extend airway epitheli cell surfac may physic restrict pathogen access under cell addit tether mucin muc differenti phosphoryl base extern stimuli influenc inflamm given muc multifunct capabl sought defin role iav infect demonstr iav direct interact muc physiolog relev model human airway epithelium hae find muc protein express elev throughout epithelium primari human monocyt deriv macrophag respons antivir signal produc infect use crisprca modifi hae demonstr effici iav infect muc genet ablat data suggest muc physic restrict iav uptak repres dynam compon host respons act inhibit viral spread yield new insight mucin mediat antivir defens

D009980;D007251;D018396

T116;T047;T005;T129

examin rotavirus innat immun evas potenti applic revers genet system rotavirus repres one success pathogen world high infect effici transmiss young mani anim speci includ human overcom host defens rotavirus evolv plethora strategi effect evad innat immun respons establish initi infect small intestin produc progeni shed environ previous studi role relat contribut specif rotavir factor innat immun evas challeng without plasmid revers genet system although still infanc current revers genet technolog help address import research question regard rotavirus innat immun evas host rang restrict viral pathogenesi review summar current knowledg antivir host innat immun defens mechan countermeasur rotavirus encod factor strategi better understand interact use rotavirus revers genet system

D012401;D012400

T047;T005

complet close genom facult generalist candidatus endoriftia persephon deep sea hydrotherm vent mutualist interact riftia pachyptila endosymbiont candidatus endoriftia persephon short endoriftia extens research howev close endoriftia genom still lack employ singl molecul real time sequenc present close chromosom sequenc endoriftia contrast theoret predict enlarg mobil genet element rich genom relat facult endosymbiont close endoriftia genom streamlin fewer expect code sequenc region insert prophag sequenc transposas code sequenc autom manual curat function analys indic endoriftia versatil regard sulphur metabol previous report identifi presenc two ident rrna operon two long crispr region close genom addit pangenom analys reveal presenc three type secret system ii iv vi differ endoriftia popul indic lineag specif adapt depth mobilom character identifi presenc share genom island differ endoriftia draft close genom suggest acquisit foreign dna predat geograph dispers differ endosymbiont popul final found evid epigenet regul endoriftia reveal gene screen absenc methyl modifi base motif genom matter fact restrict modif system seem dysfunct endoriftia point higher import molecular memori base immun phage via spacer incorpor crispr system endoriftia genom first close tubeworm endosymbiont date valuabl futur gene orient evolutionari compar studi

D060086

T070

gene edit porcin embryo use combin electropor transfect method crisprca cluster regular interspac short palindrom repeat crispr associ protein technolog grow rapid great influenc effici effect genet modif differ applic one aspect research gain import develop crisprca system introduct crispr materi target organ although previous demonstr efficaci electropor lipofect mediat crisprca gene disrupt porcin zygot still believ effici system could improv combin two method present studi thus conduct clarifi effect combin electropor lipofect deliv crisprca compon zona pellucida zp intact free zygot result reveal electropor alon signific increas biallel mutat rate result blastocyst compar lipofect alon irrespect presenc zp none zp intact zygot treat lipofectamin alon mutat suggest remov zp necessari enabl crisprca base genom edit via lipofect treatment zygot addit lipofectamin treatment electropor improv rate total biallel mutat result blastocyst deriv either zp intact free zygot

D000076987;D000072669

T063;T126;T116

reproduct effici sow insemin singl dose fix time refriger cryopreserv encapsul spermatozoa aim assess reproduct effici differ techniqu use preserv spermatozoa artifici insemin semen dose ai dose evalu refriger c cryopreserv encapsul forti two hyperprolif sow treat buserelin insemin singl fix time fertil rate embryon vesicl viabil earli embryon mortal arrest conceptus evalu post mortem th day pregnanc analys order assess effect propos techniqu result show overal reduct fertil use three propos sperm preserv techniqu refriger frozen thaw encapsul ai dose respect total number embryon vesicl similar among three treatment yet number viabl vesicl numer differ among group thus embryon viabil refriger frozen thaw encapsul ai dose respect

D012661;D012662

T059;T058;T031

molecular modif biolog activ applic chitosan deriv recent updat polysaccharid arous great interest due structur uniqu properti biocompat biodegrad absenc toxic polysaccharid marin sourc particular use due wide varieti applic biolog activ chitosan deacetyl deriv chitin exampl interest bioactiv marin deriv polysaccharid moreov wide varieti chemic modif conjug chitosan bioactiv molecul respons improv physicochem properti biolog activ expand rang applic overview synthet approach prepar chitosan chitosan deriv conjug describ discuss recent updat biolog activ applic differ research field main focus last year present highlight current trend

D048271

T121;T109

expert recommend assess manag complic due hyaluron acid soft tissu filler inject asian use hyaluron acid ha filler medic aesthet purpos increas worldwid nonetheless advers event occur patient specif issu inject techniqu product factor would mandatori consid cultur anatom featur asian prevent manag complic ha inject

D003357;D000067548

T061;T122

neural distinct fatigu low sleep qualiti multipl sclerosi fatigu low sleep qualiti multipl sclerosi ms close relat symptom associ brain function connect fc fatigu low sleep qualiti investig determin degre neural distinct symptom

D009103

T047

mix type multivari respons regress covari estim propos new method multivari respons regress covari estim element respons vector mix type exampl continu discret method base model assum observ mix type respons vector connect latent multivari normal respons linear regress link function explor properti model show paramet identifi reason condit impos parametr restrict covari latent normal posit definit therebi avoid assumpt unobserv variabl difficult verifi practic accommod general propos novel algorithm approxim maximum likelihood estim work shelf mani differ combin respons type scale well dimens respons vector method typic give better predict paramet estim fit separ model differ respons type allow approxim likelihood ratio test relev hypothes independ respons use propos method illustr simul one biomed one genom data exampl

D000465;D012107

T081;T170;T169;T062;T096

open scienc public trust scienc result two studi two studi examin whether open scienc practic make materi data code studi open access posit affect public trust scienc furthermor investig whether potenti trust damag effect research fund privat eg commerci enterpris may buffer practic preregist six hypothes conduct survey studi studi n experiment studi studi n two german general popul sampl studi found evid posit effect open scienc practic trust though note studi result inconsist howev find evid aforement buffer effect conclud open scienc practic may contribut increas trust scienc import make use open scienc practic visibl underestim

D035502

T054

diagnost laparoscopi underutil stage gastric adenocarcinoma regardless hospit type us safeti net collabor analysi diagnost laparoscopi dl key compon stage local advanc gastric adenocarcinoma ga hypothes util dl vari safeti net snh affili tertiari referr center trcs

D000230;D010535;D013274

T191;T061;T060

cultur media dmso efflux affect antibacteri activ cisplatin oxaliplatin cisplatin origin discov antibacteri action subsequ found use potent broad spectrum anticanc agent studi determin effect growth media solvent antibacteri activ cisplatin analogu oxaliplatin escherichia coli mg mg tolc treat platinum compound differ condit suscept determin result show dmso reduc activ cisplatin fourfold mic mg l compar nacl solubil cisplatin mic mg l test mop surpris complet loss activ observ mueller hinton broth ii mhb ii supplement mop individu compon mhb ii sulphur contain amino acid l cystein l methionin individu combin reduc activ fold mic mg l oxaliplatin less activ e coli mic mg l exhibit similar inactiv presenc dmso mhbii mop spike l cystein l methionin mic mg l data suggest antibacteri activ cisplatin oxaliplatin modul choic solvent composit growth media demonstr primarili due sulphur contain amino acid cystein methionin essenti compon recommend media test antimicrobi suscept mhbii

D000970;D002945

T121;T109;T197

comprehens tri nation cross section analysi characterist impact pruritus psoriasi pruritus preval psoriasi still mani featur pruritus respons therapi burden psoriasi remain better character

D000982;D011565

T121;T047

autom artifact detect reject system bodi surfac gastric map bodi surfac gastric map bsgm new clinic tool gastric motil diagnost provid high resolut data gastric myoelectr activ artifact contamin key challeng reliabl test interpret tradit electrogastrographi studi aim introduc valid autom artifact detect reject system clinic bsgm applic

D000465;D016477

T068;T170

interict dynam network transit mesial tempor lobe epilepsi reveal possibl routin brain network dynam alter patient mesial tempor lobe epilepsi mtle establish predict model seizur recurr interict period

D004833

T047

rfviii fc sever haemophilia incent switch case high risk joint bleed efmoroctocog alfa first recombin factor viii fusion protein extend half life rfviii fc hypothes lower fviii consumpt patient sever haemophilia pwsha without reduc clinic efficaci real life

D005169;D006467

T121;T047;T123;T116

new oxadiazol compound effect antibacteri antibiofilm activ staphylococcus aureus staphylococcus aureus one main aetiolog agent caus food born diseas strain produc enterotoxin respons food poison addit form biofilm sever surfac plastic glass stainless steel make difficult elimin present studi evalu first time antibacteri antibiofilm activ synthet compound lmm aureus minimum inhibitori concentr g ml aureus atcc aureus aureus fri respect time kill curv show h treatment lmm reduc approxim log cfu per ml test concentr furthermor lmm reduc aureus preform biofilm approxim log cfu per cm biofilm format reduct approxim log cfu per cm observ lmm also reduc biofilm biomass biofilm format shown crystal violet assay base result conclud lmm exhibit antibacteri antibiofilm activ may innov synthet molecul control aureus

D013203;D013211

T007;T047

effect addit ascorb dithiothreitol caspas inhibitor cryopreserv medium post thaw surviv bovin embryo produc vitro experi conduct investig whether supplement cryopreserv medium ascorb dithiothreitol dtt inhibitor caspas z devd fmk could improv post thaw surviv bovin embryo produc vitro ivp experi embryo harvest day insemin subject control rate freez medium contain ethylen glycol treatment describ experi embryo cryopreserv freez medium ascorb mm dtt z devd fmk respect post thaw surviv assess h experi embryo cryopreserv freez medium without mm ascorb h post thaw embryo total cell number dna fragment level reactiv oxygen speci ros evalu embryo subject freez thaw medium supplement mm ascorb greater p expans rate h hatch rate h compar embryo treat ascorb post thaw cryosurviv affect addit either dtt z devd fmk medium use cryopreserv embryo cryopreserv medium supplement mm ascorb reduc p level intracellular ros fewer p cell dna fragment conclus post thaw surviv bovin ivp embryo enhanc supplement freez medium ascorb

D015925;D004622

T059;T018

trait tradeoff among non nativ ectomycorrhiz fungal symbiont affect pine seedl establish hawaiian coinvas landscap pine invas lead loss nativ biodivers ecosystem function pine invas success often link coinvad non nativ ectomycorrhiz em fungi communiti composit trait distribut fungi vari landscap affect pine success understudi greenhous bioassay experi perform test effect chang em fungal communiti structur pine plantat invas front current pine free area percent root colon seedl biomass soil also analys qpcr determin chang inoculum spore densiti distanc common coinvad em fungus suillus pungen percent colon increas distanc plantat correspond increas seedl biomass stark chang em fungal communiti membership suillus spp domin current pine free area howev negat relationship pungen inoculum potenti versus root colon distanc conclud success pine invas facilit specif trait suillus spp success suillus conting lack competit ectomycorrhiz fungi

D038821;D028223

T004;T002

olfactori outcom zika virus associ guillain barr syndrom zika virus zikv infect associ guillain barr syndrom gbs howev littl known consequ zikv infect olfact human

D000086382;D020275;D000071244;D000071243

T047;T067;T005

beyond plaqu psoriasi pathogenesi treatment psoriasi phenotyp psoriasi vulgari commonest present psoriat diseas morpholog variant pustular psoriasi pp close relat diseas pityriasi rubra pilari prp known long time associ rheumatolog manifest indistinguish psoriat arthriti psa may go unrecogn often repres therapeut conundrum recent evid under genet pathogenet differ may provid basi newer therapeut approach

D015535;D001172;D010916;D011565

T047

practic manag raynaud phenomenon primer practic physician raynaud phenomenon rp common vasospast condit result digit hypoperfus respons cold andor emot stress associ signific pain disabl aim review provid practic approach clinician inform assess manag patient rp

D010820;D011928;D012595

T047;T097

pro contra synov acn pustulosi hyperostosi osteiti sapho spondyloarthr variant purpos review present date evid epidemiolog pathogenesi musculoskelet manifest imag synov acn pustulosi hyperostosi osteiti sapho syndrom discuss relationship spondyloarthr spa

D000152;D020083;D015576;D010000;D025241;D013585

T047

ethambutol induc optic neuropathi function structur chang retina optic nerv ethambutol hydrochlorid emb use treatment tuberculosi use first line modal combin medic ethambutol optic neuropathi eon rare well recognis advers ocular event patient receiv ethambutol treatment mycobacteri infect may potenti devast revers irrevers chang visual acuiti

D004977;D009901

T121;T047;T109

predictor breast self examin behavior among adult femal najran citi saudi arabia studi aim explor predictor breast self examin bse behavior among adult femal najran citi saudi arabia

D001943;D016504

T191;T060

quo vadi reactiv arthriti provid overview recent articl describ new think regard hla b associ reactiv arthriti rea includ addit infect relat arthritid trigger microb often group term rea

D016918;D000086382

T047;T067

assess perform differ outcom tumor growth studi anim model consist report result patient deriv xenograft pdx studi area concern pdx method common start implant deriv human tumor mous compar tumor growth differ treatment condit current wide array statist method eg test regress chi squar test use analyz data ultim depend outcom chosen eg tumor volum relat growth categor growth simul studi provid empir evid outcom select process compar perform common use outcom novel variat common outcom use pdx studi data simul mimic tumor growth multipl scenario outcom interest evalu iter comparison differ outcom made respect averag bias varianc type error power total continu categor time event outcom evalu ultim outcom outperform other final tumor volum chang tumor volum baselin notabl novel variat tumor growth inhibit index tgii common use outcom pdx studi found perform poor sever scenario inflat type error rate relat larg bias final outcom interest appli real world dataset

D009369

T191

iron overload disord iron overload disord repres varieti condit lead increas total bodi iron store result end organ damag elev ferritin transferrin iron satur common encount evalu elev liver enzym confirmatori homeostat iron regul hfe genet test cy hd mutat encount hereditari hemochromatosi pursu evalu hyperferritinemia magnet reson imag quantit assess iron content liver biopsi especi liver diseas caus iron overload use appropri secondari caus iron overload consid hfe genet test negat cy homozyg cyhd compound heterozyg mutat differenti diagnosi secondari iron overload includ hematolog disord iatrogen caus chronic liver diseas common hematolog disord includ thalassemia syndrom myelodysplast syndrom myelofibrosi sideroblast anemia sickl cell diseas pyruv kinas defici iron overload exclud evalu caus hyperferritinemia pursu caus hyperferritinemia includ chronic liver diseas malign infect kidney failur rheumat condit adult onset still diseas hemophagocyt lymphohistiocytosi review describ diagnost test patient suspect hereditari hemochromatosi evalu patient elev serum ferritin level sign secondari overload treatment option secondari iron overload

D006432;D000085583;D019190;D008107

T047;T033

clinic evid synergi immunotherapi radiotherapi sitar previous preclin clinic trial shown promis antitumour activ toxic profil employ synergi immunotherapi radiotherapi sitar strategi approxim one seven radiat therapi studi current recruit investig sitar articl review rang cancer known respond immunotherapi public analys sitar set background work need done futur clinic trial also review potenti toxic immunotherapi discuss area caution requir combin treatment

D007167;D009369

T191;T061

multi stage dose expans cohort msdec design bayesian stop rule phase trial design general fall three categori algorithm base eg classic design model base eg continu reassess method crm model assist design combin featur first two eg bayesian optim interv boin design classic design continu frequent use design phase trial find maximum toler dose mtd due simplic feasibl though mani model base design continu reassess method crm also propos use various immunotherapi trial mtd base three six patient accur dose expans cohort dec increas use better character toxic profil experiment agent articl propos multi stage dose expans cohort msdec hybrid frequentist bayesian design combin power prior sequenti condit probabl ratio test design result dose escal part view treat histor data weight model power prior safeti monitor bayesian stop rule develop maximum sampl size calcul fix sampl size test exact binomi comput simul studi show msdec reduc chanc patient experi toxic dose power prior provid reason prior bayesian model degre inform prior driven object histor data rather expert opinion elicit paramet model

D000465;D012107

T081;T170;T169;T062;T096

defin manag flare axial spondyloarthr flare correspond fluctuat diseas activ symptom avoid chronic inflammatori diseas axial spondyloarthr axspa work ongo better conceptualis treat flare review highlight recent data definit manag flare axspa

D000089183;D025241;D013167

T047

alter kinemat temporomandibular joint associ chronic neck pain temporomandibular disord tmd umbrella term pain dysfunct temporomandibular joint tmj associ structur patient tmd show chang tmj kinemat masticatori muscl activ tmd common comorbid non specif chronic neck pain ncnp may one risk factor tmd

D059350;D013705

T047;T184

cognit behavior therapi perinat mental health overview systemat review purpos studi determin whether cognit behavior therapi cbt start pregnanc prevent depress anxieti

D015928;D019052

T061;T048

kinet resolut aryl methylenepiperidin toward enantioenrich functionaliz piperidin fragment base n buli spartein allow kinet resolut n boc aryl methylenepiperidin disubstitut product recov start materi isol high enantiomer ratio vt nmr spectroscopi dft studi rate rotat n boc group fast lithiat trap enantioenrich start materi gave disubstitut piperidin retent stereochemistri function methylen group led varieti disubstitut piperidin without loss enantiopur could use build block drug discoveri

D013034

T121;T109

local later fear aura surgic prognost valu patient focal epilepsi fear aura tradit consid relev epilept discharg mesial tempor area studi investig effect surgic outcom drug resist epilepsi aim assess local later valu well prognost signific fear aura patient focal epilepsi

D000069279;D004828;D004827

T047;T033

novel imag techniqu sacroiliac joint assess imag sacroiliac joint one cornerston diagnosi monitor axial spondyloarthr aim present overview emerg imag techniqu sacroiliac joint assess provid insight relev benefit pitfal

D058566;D025241

T047

applic phytochem combat fungal pathogen puls approach toward inhibit fungal propag invasin activ present studi repres innov strategi inactiv secret invasin lignocellulolyt enzym fungal phytopathogen use natur phytochem combat fungal infect puls fungal pathogen aspergillus niger skp isol white lentil vigna mungo abil synthes differ lignocellulolyt enzym silico dock studi elucid quercetin naringin epigallocatechin gallat curcumin cinnam acid prime effici phytochem inhibit activ fungal invas enzym like endoglucanas endo xylanas glucoamylas consid observ extract phytochem differ mixtur appli prevent growth isol pathogen situ experiment studi minim inhibitori concentr mic minim fungicid concentr mfc valu first mixtur naringenin epicatechin gallat cinnam acid second mixtur quercetin curcumin mgl mgl respect studi phytochem establish cytosaf compar commerci fungicid seed white lentil subject year long term storag two aforement combinatori phytochem subsequ morpholog physiolog analys reveal complet protect store seed fungal infect present work enough potenti storag puls use natur preserv circumv advers effect chemic preserv ecosystem

D003474;D011794

T121;T109;T127;T130

increas explor hyperlocomot cigarett smoke lps induc murin model copd link pulmonari system inflamm brain brain relat comorbid frequent observ chronic obstruct pulmonari diseas copd relat increas diseas progress mortal date unclear mechan involv develop brain relat problem copd studi cigarett smoke lipopolysaccharid lps exposur murin model use induc copd like featur assess impact brain behavior mice daili expos cigarett smoke day except day mice intratrach expos bacteri trigger lps emphysema pulmonari inflamm well behavior brain patholog assess cigarett smoke expos mice show increas alveolar enlarg number macrophag neutrophil bronchoalveolar lavag cigarett smoke exposur result lower bodi weight accompani lower serum leptin level time spent inner zone open field decreas claudin occludin protein express level brain microvessel combin cigarett smoke lps exposur result increas locomot elev microgli activ hippocampus brain novel find show system inflamm observ combin cigarett smoke lps exposur copd model associ increas exploratori behavior find suggest neuroinflamm present brain area involv cognit function blood brain barrier integr compromis find contribut knowledg possibl process involv brain relat comorbid copd valuabl optim develop therapi strategi

D000073865;D029424

T055;T047

student inattent symptom psycholog need satisfact secondari school transit protect role teacher involv studi examin prospect relationship student inattent symptom chang psycholog need satisfact pns transit secondari school explor whether tempor associ moder teacher involv ti

D010549;D001289

T041;T048;T033

comment covid catalyst comprehens law combat potenti pandem india despit relat declin communic diseas india wit hundr outbreak everi year includ current covid pandem india suffer sever major pandem larg scale epidem sinc howev respons epidem inadequ epidem diseas act enact eda action sinc base scienc socio polit environ countri nineteenth centuri india sever legal mechan help contain control spread epidem differ platform paradigm shift socio polit milieu well scientif advanc prevent control epidem centuri old eda effect contain control epidemicspandem wit ongo covid pandem henc need revis defin appropri structur scalar chain provid clear cut unambigu termsdefinit guidelin delin ethic human right determin duti respons affect populationcommun determin role privat health sector provid appropri punit measur deter repeat violat

D000086382;D058872

T047;T067

research undergradu medic student common pitfal ethic dilemma recent time multipl attempt made involv medic student research project right earli day medic educ effort start show result student involv research workshop activ understand scientif literatur better howev need keep mind import ethic aspect may tend overlook highlight loophol exploit young research shortcut use process also focus differ measur medic student could incorpor research generat qualiti data follow ethic practic

D004504;D013337

T065;T097

attribut credit bias public ethic articl argu mani ethic problem associ authorship journal literatur use clarifi authorship place within broader concept attribut extend beyond author bylin encompass everyth reader told work origin parti respons also suggest attribut literatur grown complex opportun misattribut becom subtl multifari attribut becom increas vulner systemat bias accord defin credit bias systemat distort attribut frequent interest influenc public present four step framework evalu public discuss misattribut drug industri literatur illustr credit bias examin role editori standard mitig also assist credit bias also argu independ scientif standard promot ethic conduct medic journal sector

D001319;D011643

T057

abort law unit state turn calendar back year nation around world begun revis law restrict women access safe legal abort unit state move rapid opposit direct past year seen sever countri latin america enact new legisl includ argentina mexico colombia well chile former absolut ban prohibit abort even save life pregnant woman africa tunisia zambia south africa countri loosen restrict abort us despit near year constitut protect right abort women face array current pend restrict half fifti state case suprem court promis upend constitut right recent develop lead court decis promis revers half centuri women right abort unit state hard right overturn requir explan also call look well establish structur risk liber democraci

D000028;D000029

T093;T046;T061;T081;T033

nation medic commiss act need pariti nation medic commiss nmc replac erstwhil medic council india intent bring posit reform medic educ enforc ethic standard practic medicin india nmc act claus section detail procedur grievanc redress howev claus current form empow doctor patient unequ act empow aggriev medic profession approach relev appel fora nmc silent similar opportun aggriev patient caregiv appeal decis state medic council need amend claus ensur equit opportun aggriev patient appeal decis state medic council ensur justic

D010298

T081;T040;T033

gift authorship look gift hors mouth unmerit authorship research paper wide acknowledg constitut research misconduct differ context call gift honorari guest authorship although sever attempt made address issu remain signific problem research paper discuss accept criteria qualifi person author research public defin constitut gift authorship also look scenario india tri identifi circumst foster practic academia countri final discuss advers effect practic research enterpris whole possibl remedi measur

D001319;D015871

T068;T057;T080

mean acknowledg manuscript fresh degre biotechnolog keen get work experi decid studi wrote email sever lead research countri respond one offer internship brief interview board work laboratori intens work environ focus dedic profession spent much time benchwork design redesign experi prove hypothes intern first kind experi

D007396

T065;T097

absolut quantif plasma mitochondri dna droplet digit pcr mark covid sever time intens care unit admiss increas plasma mitochondri dna concentr associ poor outcom multipl critic ill includ covid howev current method cell free mitochondri dna quantif plasma time consum lack reproduc use next generat sequenc character size genom locat circul mitochondri dna critic ill subject covid develop facil optim method quantif droplet digit pcr sequenc reveal larg percentag small mitochondri dna fragment plasma wide variabl coverag genom locat identifi probe mitochondri dna gene cytochrom b nadh dehydrogenas region relat high coverag target small sequenc potenti miss method serial assess absolut mitochondri dna concentr determin plasma critic ill subject covid without dna isol step mitochondri dna concentr day enrol increas signific patient moder sever acut respiratori distress syndrom ard compar mild ard comparison mitochondri dna concentr time patient nomild ard surviv patient moderatesever ard surviv nonsurvivor show highest concentr patient sever diseas absolut mitochondri dna quantif droplet digit pcr time effici reproduc thus provid valuabl tool rational futur studi evalu mitochondri dna real time biomark guid clinic decis make critic ill subject covid

D000086382;D012128

T047;T067

chang intestin homeostasi immun cigarett smoke lps induc murin model copd lung gut axi chronic obstruct pulmonari diseas copd often associ intestin comorbid studi chang intestin homeostasi immun cigarett smoke cs lipopolysaccharid lps induc copd model investig mice expos cigarett smoke air day except day mice treat salin lps via intratrach instil cigarett smoke exposur increas airway inflammatori cell number mucus product differ inflammatori mediat includ c reactiv protein crp keratinocyt deriv chemokin kc bronchoalveolar lavag bal fluid serum lps impact airway inflammatori cell number mucus product decreas inflammatori mediat level bal fluid helper th cell enhanc spleen cigarett smoke exposur howev combin lps cigarett exposur caus increas th th cell histomorpholog chang observ proxim small intestin cigarett smoke exposur addit lps effect cigarett smoke activ intestin immun network iga product distal small intestin associ increas fecal siga level enlarg peyer patch cigarett smoke plus lps decreas fecal siga level size peyer patch conclus cigarett smoke without lps affect intestin health observ chang intestin histomorpholog immun network iga product elev system mediat might play role lung gut cross talk find contribut better understand intestin disord relat copd

D000073865;D029424

T055;T047

longitudin associ high volum vigor intens exercis hip fractur risk men mainten vigor exercis habit young old age consid protect hip fractur data fractur risk lifelong vigor exercis lack longitudin cohort studi examin hazard hip fractur male former athlet popul control relat exercis volum intens later year incid hip fractur age year identifi hospit discharg regist exercis covari inform obtain questionnair administ analys conduct use extend proport hazard regress model time depend exposur effect mean sd follow year athlet control sustain hip fractur adjust hazard ratio hr indic statist signific differ athlet control confid interv ci subgroup analys adjust hrs athlet recent high metabol equival hour met h week low met hweek exercis volum ci ci respect compar control adjust hr statist signific athlet low intens exercis met control ci athlet engag vigor intens exercis met least minutesweek initi lower hazard rate adjust hr ci control howev hr time depend adjust hr ci age year hrs athlet vigor intens exercis reach level control year hrs athlet increas approxim fold annual relat control conclus data suggest continu vigor intens exercis associ lower hr hip fractur old age author journal bone miner research publish wiley period llc behalf american societi bone miner research asbmr

D006620

T037

hydrocarbon tracer suggest methan emiss fossil sourc occur predomin gas process petroleum play signific sourc use global airborn observ propan c h ethan c h atmospher tomographi atom hiaper pole pole observ hippo well us base aircraft tower observ noaa ncar frapp campaign tracer emiss oil gas oper simul global mole fraction field gase updat default emiss configur c h use global chemic transport model geo chem v use scale c h spatial proxi updat emiss simul c h c h use geo chem reason agreement atom hippo observ though updat emiss field underestim c h accumul arctic wintertim point addit sourc gas high latitud eg europ use bayesian hierarch model estim global emiss c h c h fossil fuel product ci ci tgyear respect calcul bottom hydrocarbon emiss ratio use basin composit measur weight gas product find magnitud higher expect similar ratio inform revis alkan emiss suggest emiss domin pre process activ oil produc basin

D000393;D010578

T109;T131

evalu retract public dentistri systemat review object retract flaw public maintain integr scientif literatur retract dental literatur rise recent year henc aim review retract articl relat dentistri

D035843;D015871

T068;T062;T080

microbi respons micromet scale multiaxi wrinkl surfac investig effect micromet scale surfac wrinkl attach prolifer model bacteria staphylococcus aureus pseudomona aeruginosa escherichia coli k fungi candida albican specif sinusoid checkerboard c herringbon h pattern fabric mechan wrinkl plasma oxid polydimethylsiloxan pdms bilay contrast flat f surfac microbi deform orient found correl aspect ratio commensur surfac pattern dimens local pattern order signific prolifer p aeruginosa could describ linear scale bacteri area coverag avail surfac area defin fraction line integr along profil negat curvatur howev earli stage prolifer h examin c h pattern disrupt spatial arrang bacteria imped prolifer sever hour reduc thereaft find suggest simpl framework ration impact micromet scale topographi microbi action demonstr multiaxi pattern order provid effect strategi delay frustrat earli stage bacteri prolifer

D011550;D013211

T007

analyt first order deriv x ms xdw rms variant caspt raspt method cross state involv complex electron structur make accur character cross point difficult studi analyt deriv three complet activ space second order perturb theori caspt variant well extens restrict activ space raspt develop variant appli locat minimum energi conic intersect result demonstr three caspt variant predict qualit similar result recent develop variant rotat multist caspt rms caspt least sensit number state consid calcul demonstr caspt refer self consist field calcul predict qualit differ energet bond length

D011789

T170

perialar intertrigo children adolesc multicent prospect studi case observ isol case perialar intertrigo children teenag appear correspond known clinic entiti object studi describ clinic featur dermatosi clinic characterist patient

D007402;D011565;D012393

T047

vivo uranium decorpor tailor made hexadent ligand sequestr uranium particular deposit bone incomplet task chelat therapi actinid decorpor part reason previous decorpor ligand delic design meet coordin requir uranyl cation herein guid dft calcul elabor design hexadent ligand tam li mam whose preorgan planar oxo donor configur perfect match typic coordin geometri uranyl cation lead ultrahigh bind affin uranyl support vitro desorpt experi uranyl phosphat administr ligand prompt intraperiton inject demonstr uranyl remov effici kidney bone respect notabl exceed test chelat agent well clinic drug znna dtpa set new record uranyl decorpor efficaci

D008671;D014501

T196

explor rest frontal eeg reflect function matern substanc use matern substanc use associ alter neural activ poor offspr outcom may facilit suboptim caregiv form impair parent reflect function prf investig associ rest state frontal electroencephalographi eeg power substanc use mother non substanc use mother examin specifi seven frequenc band delta theta alpha alpha alpha beta gamma substanc use mother exhibit enhanc beta gamma spectral power compar non substanc use mother potenti reflect higher arous state substanc use mother group differ compon prf ie level pre mental certainti interest curios whole sampl analys reveal signific posit correl pre mental delta spectral power taken togeth find suggest potenti neural correl matern substanc use prf provid import next step examin associ matern substanc use poor child outcom

D009035;D019966

T099;T092;T048;T033

intellig supramolecular nanoprodrug base anion water solubl biphenyl extend pillar aren combin therapi anion water solubl biphenyl extend pillar aren modifi eight ammonium salt ion awbpp success synthes establish drug drug conjug supramolecular nanoprodrug snp high drug load capac snp generat synergist tripl therapeut effect photodynam therapi pdt phototherm therapi ptt chemotherapi ct ie pdt ptt ct excel biocompat

D010778;D014867

T121;T061;T197

entropi induc select switch gold catalysi fast access indolo quinolin new n heterocycl compound organ function materi effici synthes high demand surpris entropi induc select switch gold catalyz intramolecular hydroaryl ethynyl n aryl indol found exploit led straightforward synthes indolo quinolin experiment comput mechanist investig gave insight uncommon select phenomenon special reactiv indolo quinolin high function group toler methodolog enabl access divers scope high yield addit bidirect approach post function reaction extens core structur feasibl depth studi photophys properti explor structur effect relationship differ deriv reveal high potenti compound futur applic function materi

D006571;D011804

T109

effect therapi program manag chronic cough preliminari data random clinic trial purpos studi analyz effect therapi program manag chronic cough tmcc laryng sensat symptom relat cough individu chronic refractori cough crc

D003371;D007830

T023;T184;T030

stealth among univers student associ factor identifi practic stealth among univers student associ profil young peopl practic

D012725;D013334

T053;T081;T098;T055;T032

first human singl ascend dose multipl dose food interact studi nrde innov nonopioid therapi pain diabet peripher neuropathi pain diabet peripher neuropathi character burn stab electr shock type pain sever impact day day function qualiti life report result phase studi nrdse refer nrde new oral avail chemic entiti present develop treatment pain diabet peripher neuropathi first studi first human random placebo control singl ascend dose studi nrde administ healthi male subject singl dosag rang mg second studi random placebo control multipl dose studi healthi male subject receiv mg nrde daili consecut day third studi open label food interact studi healthi men women follow crossov design nrde administ fed fast condit mg studi reveal dose depend absorpt increas exposur nrde administ food relev accumul daili administr phase studi consist show rapid absorpt oral administ nrde follow fast elimin main via metabol glucuronid small secondari increas plasma concentr nrde well toler subject discontinu due treatment emerg advers event studi

D003920;D003929

T047

carbon black embed poli dimethylsiloxan paper hybrid devic energi effici nucleic acid amplif point care test paper base devic pattern carbon black poli dimethylsiloxan pdms mixtur develop heat platform nucleic acid amplif test phototherm effect carbon black nm laser irradi use conduct loop mediat isotherm amplif lamp detect escherichia coli e coli h foodborn pathogen character heat generat carbon black chang concentr hard pdms optim minimum laser power requir perform lamp propos paper base devic requir less min perform lamp result confirm base color chang observ nake eye rfbe gene e coli h specif amplifi detect limit cfu ml amplif also perform use laboratori made laser diod devic consum w h oper low cost dispos easi fabric paper base devic make power tool point care test

D019453;D053260

T007;T196;T130;T121

bmi posit associ acceler epigenet age twin pair discord bodi mass index obes herit complex phenotyp increas risk age relat outcom biolog age estim dna methyl dnam use various epigenet clock previous work suggest individu elev weight also display acceler age result vari epigenet clock popul util new epigenet clock grimag close correl mortal

D007333

T046

multidisciplinari approach cancer cachexia current servic model futur perspect cancer cachexia remain complex unmet need oncolog despit high preval high impact patient cachexia experi numer complic includ reduc toler effect anti cancer therapi reduc mobil reduc function status lead decreas qualiti life surviv

D002100;D009369

T191;T184

augment altern communic classroom teacher practic experi studi explor practic experi teacher teach student use augment altern communic aac specif speech generat devic sgds

D003142;D003143;D013663

T073;T074;T066;T054;T090;T170;T065;T097;T080

stir bar sorptiv extract devic coupl gas chromatographi flame ionize detector determin abus prescript drug lean cocktail sampl lean cocktail mix drink non medic use prescript medic emerg recent year drug abus relat drug facilit crime determin activ ingredi lean cocktail necessari forens investig work present hous develop stir bar sorptiv extract sbse devic xad adsorb follow analysi use gc fid extract determin five main abus prescript drug diphenhydramin tramadol chlorpheniramin dextromethorphan promethazin lean cocktail sampl optim condit develop method provid linear g ml five abus prescript drug limit detect limit quantit respect rang g ml g ml percentag extract intra day inter day precis rsd rsd respect good relat recoveri rang obtain propos method appli extract analysi abus prescript drug five lean cocktail sampl develop method use tool measur level abus prescript drug lean cocktail data could also use evid forens investig

D013287

T109;T131

kinemat recreat male runner super minimalist habitu shoe conduct exploratori analysi compar run kinemat male recreat runner wear nike vaporfli vp sauconi endorphin race flat flat habitu footwear also explor potenti relationship kinemat physiolog chang runner age v peak ml kg min attend session complet v peak test sagitt plane kinemat submaxim run speed v peak collect alongsid economi measur kinemat compar use notch boxplot shoe kinemat differ plot shoe economi differ across intens vp involv longer flight time ms lower stanc hip rang motion greater vertic pelvi displac flat cm peak dorsiflexion angl ankl rang motion plantarflexion veloc deg sec greatest flat lowest vp foot ground angl smaller flat select kinemat variabl moder relat economi higher step frequenc shorter step length vp flat associ improv economi versus footwear chang alter run kinemat pronounc differ observ ankl spatiotempor foot ground angl variabl

D012420;D012775

T056;T073

climat chang associ increas alloc potenti outcross common mix mate speci although balanc cross self fertil driven environ long term studi document whether anthropogen climat chang affect reproduct strategi alloc speci mix mate system test whether common blue violet viola sororia violacea alter relat alloc product potenti outcross flower climat chang throughout th centuri

D057231;D054817

T040;T070

primari cardiac synovi sarcoma present brain metastas primari cardiac synovi sarcoma rare primari cardiac tumor usual aris right side heart brain metastas primari cardiac sarcoma uncommon wild natur tumor usual poor outcom studi describ year old femal present blur vision headach nausea vomit brain lesion radiolog studi incident two dimension echocardiographi reveal left atrial lesion patient underw emerg cardiac surgeri resect left atrial mass aros atrial free wall pulmonari vein diagnosi lesion primari synovi sarcoma histopatholog examin

D001932;D006338;D011667;D013584

T191;T047;T023

ultrafast simultan select depolymer heterogen stream polyethylen terephthal polycarbon toward industri feasibl chemic recycl mix plastic wast stream main obstacl extens implement polym recycl separ mix plastic wast stream demand time effort collect recycl plant mani product consist multipl polym readili separ chemic recycl could provid key overcom issu target specif chemic bond enabl select depolymer singl polym class mixtur work explor depolymer polycarbon pc polyethylen terephthal pet separ mix stream select depolymer mix stream compos pet pc one step separ constitu monom carri outstand energi effici inexpens koh methanol hydrolysi kmh process develop instantan pet hydrolysi activ energi depolymer pc pet pellet kj mol respect random mix stream fulli depolymer within min c use ml depolymer solut per gram polym separ bisphenol terephthal acid demonstr one step separ process yield puriti without secondari reaction detect simultan depolymer select one step separ monom also demonstr petpc polym blend prepar solut cast show process also work intim mix petpc mixtur

D011093;D059027

T068;T109;T122

temperatur sensit anti inflammatori organohydrogel contain janus particl stabil phase chang microinclus fabric strategi multifunct organohydrogel propos combin phase chang microinclus within doubl network dn hydrogel stabil janus particl janus particl possess reactiv colloid stabil robust organohydrogel interstic among janus particl enhanc mass transfer phase interfac moreov dn hydrogel achiev dynam cross link network endow organohydrogel inject self heal perform phase chang microinclus benefici organohydrogel temperatur respons mechan properti temperatur program shape memori perform organohydrogel employ temperatur therapi melt crystal process phase chang microinclus simultan payload within microinclus releas antibacteria upon melt encapsul wax organohydrogel serv ideal dress temperatur respons mechan properti temperatur therapi effect temperatur trigger antibacteri abil

D000080873

T073

effect comput train teach spanish book share strategi mother emerg bilingu risk development languag disord singl case design studi purpos research examin effect comput app base train program caregiv caregiv behavior enhanc spanish languag emerg bilingu risk development languag disord

D007805;D009035

T047;T092;T099;T048;T033