Datasets:

JesusCrist

/

iepile_benchmark

like 0

655b0c6a09b6ca97219be84d4270188763a555b8a4719022a6dbfe10d4aebfea

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "CONCLUSION : Gemcitabine - induced recall pneumonitis is a rarely reported phenomenon and should be taken into account even after extended time interval to the previous radiotherapy ."}

[{"head": "recall pneumonitis", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Gemcitabine", "tail_type": "", "tail_pos": []}]

f8fdd6522a121ce5530c829a0bed51d39164e30dde12e0eb2741aa98cb9f6353

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "CONCLUSION : The present findings suggest that fluvoxamine can cause increased libido in some patients ."}

[{"head": "increased libido", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "fluvoxamine", "tail_type": "", "tail_pos": []}]

d51fb768db30a4f3293df4bd2910f3fd093972ca0918516aa159320073198e94

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Malignant mixed mullerian tumor of the uterus in a patient taking raloxifene ."}

[{"head": "Malignant mixed mullerian tumor of the uterus", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "raloxifene", "tail_type": "", "tail_pos": []}]

bdd654325d5decdd2d093e6b584b995ccb5abbd803883ca148223b72ca4e8c0f

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Pneumocystis carinii pneumonia as a complication of methotrexate treatment of asthma ."}

[{"head": "Pneumocystis carinii pneumonia", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "methotrexate", "tail_type": "", "tail_pos": []}]

c7ccb51cd661f058fb1bec386b537cdc929b0c460253efe258428b7f2257f37d

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "BACKGROUND : How to best treat psychotic patients who have had past clozapine - induced agranulocytosis or granulocytopenia remains a problem ."}

[{"head": "granulocytopenia", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "clozapine", "tail_type": "", "tail_pos": []}]

29df0b1f7413a5ae8c8bc4116b09f535a872a7e13f81270cf2df95d98d96214a

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "We suggest that meloxicam might have intestinal toxic effects when taken in high doses , because of reduced COX-2 selectivity ."}

[{"head": "intestinal toxic effects", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "meloxicam", "tail_type": "", "tail_pos": []}]

a000e2b89aa4e576b1af2b4314aee1a6b3a126466ac82e576e42cc6b6b420bac

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "A study of in vitro reactivity to L - T4 , as assessed by peripheral blood lymphocyte transformation , was carried out in a patient with Hashimoto 's disease who developed leukopenia during treatment with L - T4 ."}

[{"head": "leukopenia", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "L - T4", "tail_type": "", "tail_pos": []}]

6e27a9b674f7159565dfcf881bf954b11dfb0dbf809d31c8c0b2a03e04ca7ce3

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Nine eyes from 6 patients , 74 years to 90 years of age , referred by ophthalmologists for repair of cicatricial entropion after at least 2 years of twice - a - day application of dipivefrin ."}

[{"head": "cicatricial entropion", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "dipivefrin", "tail_type": "", "tail_pos": []}]

83c6e417df0e5430d167cad73f2cdb6b5ddcb6c9c23d54eb8de7feb234cb7d86

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Thrombocytopenia with or without microangiopathy following quinine is often referred to as quinine \" hypersensitivity . \" When schistocytes are present it is frequently termed \" quinine - associated TTP / HUS . \" A severe deficiency of the vWF - cleaving protease , ADAMTS13 , is associated with idiopathic TTP ."}

[{"head": "Thrombocytopenia", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "quinine", "tail_type": "", "tail_pos": []}, {"head": "TTP / HUS", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "quinine", "tail_type": "", "tail_pos": []}]

af01f032860a66ff47baa30194c7af3fb38725f3b84e5cd4902e6de579c3f0b5

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "In these patients , long - acting octreotide may trigger serious hypoglycemia ."}

[{"head": "serious hypoglycemia", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "octreotide", "tail_type": "", "tail_pos": []}]

39e9ccb73bbcea9485a2698e89f7938e8f21226123613104dfaaafa2dd9d80a2

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Tigecycline - induced acute pancreatitis : case report and literature review ."}

[{"head": "acute pancreatitis", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Tigecycline", "tail_type": "", "tail_pos": []}]

f924e44e9f7c0374de27b77b6e53a774bb4aa944b373c868acceccb68240eb39

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "We observed 3 diabetic patients with intolerable dizziness followed by nausea and vomiting immediately after an initial administration of the alpha - glucosidase inhibitor , voglibose ."}

[{"head": "intolerable dizziness", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "voglibose", "tail_type": "", "tail_pos": []}, {"head": "nausea", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "voglibose", "tail_type": "", "tail_pos": []}, {"head": "vomiting", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "voglibose", "tail_type": "", "tail_pos": []}]

29ae21c19fbd4c0d025dd5f6c73cbf4c44c49f3c0c4e11b4c74edde2c9f39166

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Methadone - induced myoclonus in advanced cancer ."}

[{"head": "myoclonus", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Methadone", "tail_type": "", "tail_pos": []}]

1d6bd07406e150ab919900e6e8d06e575a53252e1aa0363a7166622d189811a7

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Until additional data are available , if intravenous acyclovir is administered concurrently with lithium , we recommend closely monitoring patients for signs of lithium toxicity and measuring serum lithium levels every second or third day ."}

[{"head": "lithium toxicity", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "acyclovir", "tail_type": "", "tail_pos": []}, {"head": "lithium toxicity", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "lithium", "tail_type": "", "tail_pos": []}]

427b89ffad821828dc819128ad6fd5dabaf20c68e269117e626f524c8d79b9ed

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Docetaxel induced Meibomian duct inflammation and blockage is the likely cause of this presentation in a patient with no history of eyelid masses in the past ."}

[{"head": "Meibomian duct inflammation and blockage", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Docetaxel", "tail_type": "", "tail_pos": []}]

07ec81d9d86a75a7f1bec56f1d7617860058f283ea0a8e9abbeb38b54bb52ce5

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "In this article , we describe a Japanese patient with severe interstitial pneumonia probably caused by sorafenib treatment for metastatic renal cell carcinoma ."}

[{"head": "severe interstitial pneumonia", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "sorafenib", "tail_type": "", "tail_pos": []}]

bcd583517aed65088af1b4b9571ddd6f0a888212cd591812d284a9b660fc3ba5

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Rapamycin / sirolimus - induced pneumonitis has been described previously in renal transplant recipients , and this report describes a stable heart - lung transplant recipient who developed a pulmonary infiltrate that reversed after ceasing SR therapy ."}

[{"head": "pneumonitis", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Rapamycin", "tail_type": "", "tail_pos": []}, {"head": "pneumonitis", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "sirolimus", "tail_type": "", "tail_pos": []}, {"head": "pulmonary infiltrate", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Rapamycin", "tail_type": "", "tail_pos": []}, {"head": "pulmonary infiltrate", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "sirolimus", "tail_type": "", "tail_pos": []}, {"head": "pulmonary infiltrate", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "SR", "tail_type": "", "tail_pos": []}]

868d22e306f87fd63c20a5a9f749544ba1ee0f3096f95631203049c4e6a3d083

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "The time course of events suggested that amphotericin B was the cause of the seizures in this AIDS patient ."}

[{"head": "seizures", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "amphotericin B", "tail_type": "", "tail_pos": []}]

1288082dd8366c74d10a7d29f4965d70071b5b08b9a0a96e0a94f7b599cca9d7

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "To our knowledge , this is the first case of griseofulvin - exacerbated lupus in which nephrotic syndrome has been observed ."}

[{"head": "lupus", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "griseofulvin", "tail_type": "", "tail_pos": []}, {"head": "nephrotic syndrome", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "griseofulvin", "tail_type": "", "tail_pos": []}]

cddbae16bc69cf43a963e62d99ac014cbc44af9bf7a0a469127fa37097989b14

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Acute hepatic failure is a rare and potentially lethal complication of propylthiouracil ( PTU ) use for hyperthyroidism ."}

[{"head": "Acute hepatic failure", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "propylthiouracil", "tail_type": "", "tail_pos": []}, {"head": "Acute hepatic failure", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "PTU", "tail_type": "", "tail_pos": []}]

d3d602d8dba1ccab6da99a708df752ac2ad36f4fbe78c6e07233de786c38008c

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Charcoal haemoperfusion and cysteamine therapy led to the rapid removal of the paracetamol from the body and consequently prevented the development of severe hepatic necrosis ."}

[{"head": "severe hepatic necrosis", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "paracetamol", "tail_type": "", "tail_pos": []}]

1060f0953c8d7679c023d869041a3eab85b149f03cd96647fc7b2c74a00bf41d

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Although interferon gamma has been implicated in the pathogenesis of sarcoidosis , only a few cases of sarcoidosis associated with interferon alpha therapy have been reported ."}

[{"head": "sarcoidosis", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "interferon alpha", "tail_type": "", "tail_pos": []}]

b9dd2692abcc362499511162b577cc14939d1c40db288015edf6110aff0a761d

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Retinal dysfunction and anterior segment deposits in a patient treated with rifabutin ."}

[{"head": "anterior segment deposits", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "rifabutin", "tail_type": "", "tail_pos": []}, {"head": "Retinal dysfunction", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "rifabutin", "tail_type": "", "tail_pos": []}]

dfe1967f195cd75a9b8b28381de381d2efb1fb8a5a5527646ae6508efd6a3487

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Other potential causes of renal failure were not present in our patient and his renal function gradually recovered with the cessation of suramin treatment ."}

[{"head": "renal failure", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "suramin", "tail_type": "", "tail_pos": []}]

356c851e3bc91d3be54c0ba0096943f1422c987c09de2eb8a9589bb9433a09c1

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "With the increasing use of Cyclosporine A in transplant patients , the incidence of herpes esophagitis may increase ."}

[{"head": "herpes esophagitis", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Cyclosporine A", "tail_type": "", "tail_pos": []}]

d59b0f895ba7b205cb12846bcbc73d8cea757fda01751a36952430ab96520a56

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment ."}

[{"head": "hypersensitivity myocarditis", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "clozapine", "tail_type": "", "tail_pos": []}, {"head": "Sudden cardiac death", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "clozapine", "tail_type": "", "tail_pos": []}]

74126c4f9d91ce53a76e28b613c27e1fa7b6209961d18e3b908879560f690323

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "We present a fatal case of subacute methanol toxicity with associated diffuse brain involvement , including bilateral putaminal necrosis and cerebral edema with ventricular compression ."}

[{"head": "bilateral putaminal necrosis", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "methanol", "tail_type": "", "tail_pos": []}, {"head": "cerebral edema", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "methanol", "tail_type": "", "tail_pos": []}, {"head": "diffuse brain involvement", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "methanol", "tail_type": "", "tail_pos": []}, {"head": "fatal", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "methanol", "tail_type": "", "tail_pos": []}, {"head": "methanol toxicity", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "methanol", "tail_type": "", "tail_pos": []}, {"head": "ventricular compression", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "methanol", "tail_type": "", "tail_pos": []}]

6337c55f42038dd840464456aac032cdb717308b93a59ea62b27190adf1fc400

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Livedo reticularis associated with interferon alpha therapy in two melanoma patients ."}

[{"head": "Livedo reticularis", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "interferon alpha", "tail_type": "", "tail_pos": []}]

d961b312266372fc4e72d5f07e53f5c24b954cb4e9e1c080eb73af0b0ca3f089

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Lethargy in a newborn : lithium toxicity or lab error ?"}

[{"head": "Lethargy", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "lithium", "tail_type": "", "tail_pos": []}, {"head": "lithium toxicity", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "lithium", "tail_type": "", "tail_pos": []}]

070b59d340ff562e6fda86dc42b7088113309d957a36c3b14816a824aade3d3f

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Fixed drug eruption of the scrotum due to methylphenidate ."}

[{"head": "Fixed drug eruption of the scrotum", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "methylphenidate", "tail_type": "", "tail_pos": []}]

5cbdb673beff8ab4bc2d05ac104135a8385d1ca09a499b95052acacd08ed343c

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Neurological side effects in two patients receiving gold injections for rheumatoid arthritis ."}

[{"head": "Neurological side effects", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "gold", "tail_type": "", "tail_pos": []}]

e649401f82c0f3d75a921e2a75d6250c5b4aa680f473aa1a8eacd425ad289d1a

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Withdrawal of Depakote resulted in resolution of the effusion ."}

[{"head": "effusion", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Depakote", "tail_type": "", "tail_pos": []}]

bef8916b7514c0885f4506e4c67a623645014e41e6fd57a6857457d8e46993a7

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "A case of colchicine - induced rhabdomyolysis is reported ."}

[{"head": "rhabdomyolysis", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "colchicine", "tail_type": "", "tail_pos": []}]

86a35116886a0f6707f864eb6eb86e00cf34c3387789fb6a9589737913f799aa

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "In patients with a known access to INH , seizures should be considered to be caused by INH toxicity unless proved otherwise ."}

[{"head": "seizures", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "INH", "tail_type": "", "tail_pos": []}]

07066f4bf8f05b62352b5b9f38cf67835870ad10fdaec5664c34d9e222d51bf4

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "METHODS : A 76-year - old woman with primary open - angle glaucoma and no history of ocular surgery developed a choroidal detachment 12 hours after initiation of therapy with dorzolamide eye drops ."}

[{"head": "choroidal detachment", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "dorzolamide", "tail_type": "", "tail_pos": []}]

a7167fba1cb96009c9c26593263d2268b4f1f148ccace02f768ef36a24139300

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Fulminant hepatic failure developed in a 24-year - old black woman who had been treated with propylthiouracil and propranolol for hyperthyroidism ."}

[{"head": "Fulminant hepatic failure", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "propranolol", "tail_type": "", "tail_pos": []}, {"head": "Fulminant hepatic failure", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "propylthiouracil", "tail_type": "", "tail_pos": []}]

dfe266a35e44b313c09e2b54ebf74d10d9b89922c3d450e1da96bd6720bb4a96

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "The induction of hypoglycaemia with PAS in this patient suggests a potential role for PAS in the treatment of diabetes mellitus ."}

[{"head": "hypoglycaemia", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "PAS", "tail_type": "", "tail_pos": []}]

9c9f14244ea6be04bae40e00ca569067f7b41045bc457561781ad7599744cac1

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "The probability of developing acute leukemia in this study was not significantly correlated to the total cumulative dosage of Treosulfan ."}

[{"head": "acute leukemia", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Treosulfan", "tail_type": "", "tail_pos": []}]

509c8a721c2be291172184a9e80244bb40347d2c71f30b6068d118ffb26b9d37

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "We report here a case of cardiovascular and neurological depression induced by oxymetalzoline in a toddler ."}

[{"head": "neurological depression", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "oxymetalzoline", "tail_type": "", "tail_pos": []}]

67b2a96d5ce4cfd1b805fd3528cfc72f6c75646870f54cc8e6567e153f3a2cf0

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Here , we report a case of angio - oedema associated with VRC therapy ."}

[{"head": "angio - oedema", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "VRC", "tail_type": "", "tail_pos": []}]

8d15751c08652d3925267c9fb21992b69ec935b0441b2310f84633ec1faf3952

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "The syndrome of irreversible lithium - effectuated neurotoxicity ( SILENT ) ."}

[{"head": "neurotoxicity", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "lithium", "tail_type": "", "tail_pos": []}]

e56ed1934b2410b5b36056630bfe3ff3b296d7828a9ff45317d7c322aa7ac912

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "This article presents a case of an atypical localized cutaneous eruption with an unusual course and protracted resolution time associated with sorafenib therapy ."}

[{"head": "atypical localized cutaneous eruption", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "sorafenib", "tail_type": "", "tail_pos": []}]

a2e34e06dea59e0df22ab1e22198f60c60ac9d4745c56adc386d4121e3fb7d1b

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "This report presents a potential case of risperidone - induced tardive dyskinesia ."}

[{"head": "tardive dyskinesia", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "risperidone", "tail_type": "", "tail_pos": []}]

2c2acdc077e6108b633ddd1023e97f75acf65dc53dbc7132d7986b4ea7c54396

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Myoclonic spasms following intrathecal morphine ."}

[{"head": "Myoclonic spasms", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "morphine", "tail_type": "", "tail_pos": []}]

30a2fbf69596d23ffb50a6255651543928d9aa43ce4acfd19a2229a73b3a2ef3

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "An 8-year - old girl , who had been vaccinated with BCG without subsequent regional reactions , developed osteomyelitis in the left calcaneus 7 months later ."}

[{"head": "osteomyelitis in the left calcaneus", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "BCG", "tail_type": "", "tail_pos": []}]

6f49fdb1e2e3ebdf8796a4be96bcb28631b01ece2a498795067c50ede210917a

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "After having received gemcitabine on day 1 of the second course , the patient developed dry cough , subfebrile temperatures and dyspnea within 48 h ."}

[{"head": "dry cough", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "gemcitabine", "tail_type": "", "tail_pos": []}, {"head": "dyspnea", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "gemcitabine", "tail_type": "", "tail_pos": []}, {"head": "subfebrile temperatures", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "gemcitabine", "tail_type": "", "tail_pos": []}]

bcd53894e6f59961dc8f472812803c6d49e79e145f6a7701137bb798f11a47bd

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Serotonin syndrome induced by transitioning from phenelzine to venlafaxine : four patient reports ."}

[{"head": "Serotonin syndrome", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "phenelzine", "tail_type": "", "tail_pos": []}, {"head": "Serotonin syndrome", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "venlafaxine", "tail_type": "", "tail_pos": []}]

49deeee269794a38519e4014242b2ffae506f3e8f9a5fac39e26a2cdf621792d

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Both colchicine and statin therapy may be associated with myopathy , which usually occurs after several months of therapy ."}

[{"head": "myopathy", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "colchicine", "tail_type": "", "tail_pos": []}, {"head": "myopathy", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "statin", "tail_type": "", "tail_pos": []}]

b0792ac7a32fe93200fd536ea52a757cd6463ebede0ac0d6b4a3ae538a591cdf

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Amiodarone hydrochloride , a new antiarrhythmic agent , has been associated with pulmonary toxicity characterized by cough , dyspnea and diffuse pulmonary infiltrates ."}

[{"head": "cough", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Amiodarone hydrochloride", "tail_type": "", "tail_pos": []}, {"head": "diffuse pulmonary infiltrates", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Amiodarone hydrochloride", "tail_type": "", "tail_pos": []}, {"head": "dyspnea", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Amiodarone hydrochloride", "tail_type": "", "tail_pos": []}, {"head": "pulmonary toxicity", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Amiodarone hydrochloride", "tail_type": "", "tail_pos": []}]

b2f233109f83316fcb2a7097950700ea9f39486ee5bb9528d6a2c52f0c03fc32

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Pregabalin - induced cortical negative myoclonus in a patient with neuropathic pain ."}

[{"head": "cortical negative myoclonus", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Pregabalin", "tail_type": "", "tail_pos": []}]

6eb274737a4275fa1ee95095aab787a5441563e68ce7ba0b1ad63ad8389d9f88

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "We report a male patient with advanced AIDS who developed hypercalcemia 2 weeks after institution of rhGH therapy ."}

[{"head": "hypercalcemia", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "rhGH", "tail_type": "", "tail_pos": []}]

525ff75f119bc0cab9d09ea85ad3c950dfc2035a017e0d6bb285d763016422e2

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability , a profound burst - suppression EEG pattern , and cranial nerve areflexia ."}

[{"head": "cortical hyperexcitability", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "CBZ", "tail_type": "", "tail_pos": []}, {"head": "cranial nerve areflexia", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "CBZ", "tail_type": "", "tail_pos": []}, {"head": "profound burst - suppression EEG pattern", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "CBZ", "tail_type": "", "tail_pos": []}, {"head": "reversible encephalopathy", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "CBZ", "tail_type": "", "tail_pos": []}]

ad5efd6d13783dbb43d373542902f662fb4fc769ff8d9aba422b392fac730903

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "A 35-year - old man with seropositive rheumatoid arthritis developed selective IgA deficiency during treatment with fenclofenac ."}

[{"head": "IgA deficiency", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "fenclofenac", "tail_type": "", "tail_pos": []}]

945f606fa9c6dc1d89a5b7c9b5b8be275d0bd6cb774a2d234e1ea0f9d74e2a71

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Minor electrocardiographical changes were noted in five out of six patients who were not receiving a cardiac glycoside and four out of six who were receiving ouabain , and none of the 16 who were receiving digoxin ."}

[{"head": "Minor electrocardiographical changes", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "ouabain", "tail_type": "", "tail_pos": []}]

d12d25c452f98eb3b1a8cc1af4c8f4e3e5bc4fa283fe1710ae7a4746acca63e5

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Severe hepatotoxicity from phenobarbital occurred in an infant boy who had a complicated illness with chronic bilateral subdural hematomas and sepsis ."}

[{"head": "Severe hepatotoxicity", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "phenobarbital", "tail_type": "", "tail_pos": []}]

c42d39218f93d91caf6ac160cb70cbd9e367641c2ce167b8f70b2d8ef30e4604

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "We observed 2 cases of hepatotoxicity after a high - dose methylprednisolone treatment of a demyelinating disease and evaluated the potential relationship in the light of available evidence ."}

[{"head": "hepatotoxicity", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "methylprednisolone", "tail_type": "", "tail_pos": []}]

996a76d6b1cb75c00b8325e16d37c12821cb1065efc8ea57c66eae27ea17ba35

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "In both cases , high fever , skin rash , liver dysfunction and atypical lymphocytosis developed 3 weeks after initiating treatment with SASP ."}

[{"head": "atypical lymphocytosis", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "SASP", "tail_type": "", "tail_pos": []}, {"head": "high fever", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "SASP", "tail_type": "", "tail_pos": []}, {"head": "liver dysfunction", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "SASP", "tail_type": "", "tail_pos": []}, {"head": "skin rash", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "SASP", "tail_type": "", "tail_pos": []}]

7b34a57864f1541a2b73b83aef3dc2eb2191dab92e229297af13b6c5865295e2

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "A patient with severe cholestatic jaundice induced by captopril is presented ."}

[{"head": "severe cholestatic jaundice", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "captopril", "tail_type": "", "tail_pos": []}]

c041e26ddfe75fad99f1494a2a34ded59eeb2777dbc25ff1f0ffab5adf82e01c

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "We present a case of a sustained monomorphic ventricular tachycardia following adenosine infusion ."}

[{"head": "sustained monomorphic ventricular tachycardia", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "adenosine", "tail_type": "", "tail_pos": []}]

1c0dd95ecd366918a2298132ff48b335a63fb3b34574bcc26936a845e8bd6936

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Acute hemorrhagic gastritis associated with acetazolamide intoxication in a patient with chronic renal failure ."}

[{"head": "acetazolamide intoxication", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "acetazolamide", "tail_type": "", "tail_pos": []}, {"head": "Acute hemorrhagic gastritis", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "acetazolamide", "tail_type": "", "tail_pos": []}]

2512b83d94671b54f65e0fe13a42601611c6478257e8551deb11d9740fc0708d

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Ramipril - induced cutaneous vasculitis is particularly rare and our case was atypical because the patient had tolerated lisinopril before ."}

[{"head": "cutaneous vasculitis", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Ramipril", "tail_type": "", "tail_pos": []}]

dedecebdfd9566b89aa3878316c016b557662ef70b207bc4684f505fdcc40282

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Gabapentin toxicity in renal failure : the importance of dose adjustment ."}

[{"head": "renal failure", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Gabapentin", "tail_type": "", "tail_pos": []}]

2733a3a9411f964e963db68ed55b9f2d762096f47cf8cb7a1af0dcda6f20d308

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Five patients are described in whom only gentamicin sulfate appeared responsible for acute renal failure ."}

[{"head": "acute renal failure", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "gentamicin sulfate", "tail_type": "", "tail_pos": []}]

726f037391c5760a89f6504e379869679ef739aa7aadef25f7fadc28c8818820

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Based on the Naranjo algorithm , the adverse reaction observed was probably related to the hydroxyurea treatment ( score = 6 ) ; however , the hydroxyurea chemotherapy could not be discontinued because of the myeloproliferative disorder ."}

[{"head": "myeloproliferative disorder", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "hydroxyurea", "tail_type": "", "tail_pos": []}]

3de14706d04cd52745c3c0c3cbd4182fe40d3d9c665185f51a54606ca020fd8a

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Use of the Naranjo probability scale determined the association between cephalosporin use and leukopenia to be probable ."}

[{"head": "leukopenia", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "cephalosporin", "tail_type": "", "tail_pos": []}]

7cb19dfd6c28589c8814f14f279a887d9dacfcc6b09409713ad6a55cc4d3957b

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Fatal interstitial pneumonitis following high - dose intermittent chlorambucil therapy for chronic lymphocyte leukemia ."}

[{"head": "Fatal interstitial pneumonitis", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "chlorambucil", "tail_type": "", "tail_pos": []}]

3b9964af4912b2703de83e19cd3b732bf54d3550e6ba8fda080d40787fd44a8b

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Pulmonary fibrosis subsequent to high doses of CCNU for chronic myeloid leukemia ."}

[{"head": "Pulmonary fibrosis", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "CCNU", "tail_type": "", "tail_pos": []}]

18d11166f11a3f19bb7c4a08659878e58a03d06b67601ec3fba851c62454d083

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Nitrofurantoin - induced acute liver damage in pregnancy ."}

[{"head": "acute liver damage", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Nitrofurantoin", "tail_type": "", "tail_pos": []}]

8aa726f4adb0a4402e18fe329378afc02cf9e296dadc3f743a1a04b9cf517055

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "The use of pamidronate for hypercalcemia secondary to acute vitamin D intoxication ."}

[{"head": "vitamin D intoxication", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "vitamin D", "tail_type": "", "tail_pos": []}]

8dd7c021be6ceecbd4cad4f7988c9fa9c5fad128ae4d0a10f785fd03b4abca25

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "We report a case of a women in whom a malignant mixed mesodermal tumor was diagnosed while she was taking raloxifene , which is also a selective estrogen receptor modulator ."}

[{"head": "malignant mixed mesodermal tumor", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "raloxifene", "tail_type": "", "tail_pos": []}]

fa789fc26c18474817e6c20ef9d55072f36c56a5683dd18027146b4287222e96

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "CONCLUSION : There are only a few confirmed cases of gemcitabine - associated HUS despite the widespread use of the drug ."}

[{"head": "HUS", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "gemcitabine", "tail_type": "", "tail_pos": []}]

aab456e12404b23bd9431428447a89b400f0d0516aa95290a7e1fdca77cb1ee5

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Onset of male gynaecomastia in a patient treated with sunitinib for metastatic renal cell carcinoma ."}

[{"head": "gynaecomastia", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "sunitinib", "tail_type": "", "tail_pos": []}]

42636a38e6e5521486591d14c573ba720c2ac913c9ffa03b00260a152bed92e3

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "A case of fluoxetine induced seizures , in a person with Down syndrome , is described ."}

[{"head": "seizures", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "fluoxetine", "tail_type": "", "tail_pos": []}]

c600542a0245f82fddde2ac727bed5ba7bb5c42386eb846c2d5cd021283fd051

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "We report a case of a 60-year - old woman affected by squamous lung carcinoma , who developed paroxysmal supraventricular tachycardia during cisplatin and etoposide combination chemotherapy ."}

[{"head": "paroxysmal supraventricular tachycardia", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "cisplatin", "tail_type": "", "tail_pos": []}, {"head": "paroxysmal supraventricular tachycardia", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "etoposide", "tail_type": "", "tail_pos": []}]

c07e875672b4d9a56084f0fdea12f6e567488ab28c1e53c01b2220769a012ec5

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Common adverse events ( frequency 10 % ) of lacosamide doses up to 600 mg / day include nonspecific central nervous system effects ( e.g. , dizziness , ataxia , diplopia , and somnolence ) ."}

[{"head": "ataxia", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "lacosamide", "tail_type": "", "tail_pos": []}, {"head": "diplopia", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "lacosamide", "tail_type": "", "tail_pos": []}, {"head": "dizziness", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "lacosamide", "tail_type": "", "tail_pos": []}, {"head": "somnolence", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "lacosamide", "tail_type": "", "tail_pos": []}]

2bddd734fc0ef0b3e77dd28a2f12acd7096f18aad7a20b3d5f9cebe735a0168e

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "We report a case of a patient with rheumatoid arthritis treated with low - dose methotrexate ( 15 mg / week ) who developed infection with both M. tuberculosis and M. chelonae after the revision of a prosthetic hip ."}

[{"head": "infection with both M. tuberculosis and M. chelonae", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "methotrexate", "tail_type": "", "tail_pos": []}]

38e518596c6e18c575ca05d1ef1293e88531fdb9b3df11536bfc335b3d554ff4

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Two patients had ampicillin - associated seizures ."}

[{"head": "seizures", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "ampicillin", "tail_type": "", "tail_pos": []}]

7569c656c055c73cd2392f38337888ffbc56aca5e6e6c9c20e00edbffe9a57d4

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Valproate embryopathy in three sets of siblings : further proof of hereditary susceptibility ."}

[{"head": "Valproate embryopathy", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Valproate", "tail_type": "", "tail_pos": []}]

644c8792c2cdb8630a0cb97e068532e8376e60c9a0801499bc981599236f20ef

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "A literature review revealed 83 other reported cases of rifampicin - induced renal insufficiency ."}

[{"head": "renal insufficiency", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "rifampicin", "tail_type": "", "tail_pos": []}]

3e8bd340d75f9fc01eb6616acd72d4c8a1c16dab7e9e7ff0a14d431bfeee364d

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "A 60-year - old white man with chronic bronchitis was noted to develop acute respiratory failure and metabolic acidosis four days after being started on methazolamide ( Neptazane ) for an ophthalmologic problem ."}

[{"head": "acute respiratory failure", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "methazolamide", "tail_type": "", "tail_pos": []}, {"head": "acute respiratory failure", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Neptazane", "tail_type": "", "tail_pos": []}, {"head": "metabolic acidosis", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "methazolamide", "tail_type": "", "tail_pos": []}, {"head": "metabolic acidosis", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Neptazane", "tail_type": "", "tail_pos": []}]

8d9a90260fe0f1540b197900d92def34580650daf179a79a78bcb804ffaa36ce

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "On the fifth day of tocolysis with magnesium sulfate , nifedipine , terbutaline and betamethasone , edema developed in both labia ."}

[{"head": "edema", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "betamethasone", "tail_type": "", "tail_pos": []}, {"head": "edema", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "magnesium sulfate", "tail_type": "", "tail_pos": []}, {"head": "edema", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "nifedipine", "tail_type": "", "tail_pos": []}, {"head": "edema", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "terbutaline", "tail_type": "", "tail_pos": []}]

6cf668823ad0075b39cd1e94548eef8df94b948b68df4e490b18cf4b97364f1b

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Thrombotic microangiopathy with renal failure in two patients undergoing gemcitabine chemotherapy ."}

[{"head": "renal failure", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "gemcitabine", "tail_type": "", "tail_pos": []}, {"head": "Thrombotic microangiopathy", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "gemcitabine", "tail_type": "", "tail_pos": []}]

bbd1d8453ae811ab244304c9cb41a2bb25348b1122fa9f86b971f1e05b591e30

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Acute esmolol toxicity may be self - limiting because of its extremely short half - life ."}

[{"head": "esmolol toxicity", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "esmolol", "tail_type": "", "tail_pos": []}]

0d7e8b295b4a45717163364b10fa051a31a5e6263f2f56ede5369f0922d227b7

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "We describe the exceptional development of AML and lung cancer in a patient with previously diagnosed CLL in minimal residual disease status after fludarabine treatment followed by autologous peripheral blood stem - cell transplantation ."}

[{"head": "AML", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "fludarabine", "tail_type": "", "tail_pos": []}, {"head": "lung cancer", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "fludarabine", "tail_type": "", "tail_pos": []}]

5cf360040b0e264157d1658ce4efbde1d7980de68d36a79e21658a775c62fedb

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Continuous EEG monitoring is helpful in managing seizures that occur as a complication of CBZ OD , after the course of recovery or worsening , and in providing assistance with prognosis ."}

[{"head": "seizures", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "CBZ", "tail_type": "", "tail_pos": []}]

ba35f5d6adbf886a12512249e5244b1e79168dfce439a1456b65c50719f079f6

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "DATA SYNTHESIS : Genetic deficiencies in DPD , the rate - limiting enzyme responsible for 5-FU catabolism , may occur in 3 % or more of patients with cancer putting them at increased risk for unusually severe adverse reactions ( e.g. , diarrhea , stomatitis , mucositis , myelosuppression , neurotoxicity ) to standard doses of 5-FU ."}

[{"head": "diarrhea", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "5-FU", "tail_type": "", "tail_pos": []}, {"head": "mucositis", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "5-FU", "tail_type": "", "tail_pos": []}, {"head": "myelosuppression", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "5-FU", "tail_type": "", "tail_pos": []}, {"head": "neurotoxicity", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "5-FU", "tail_type": "", "tail_pos": []}, {"head": "stomatitis", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "5-FU", "tail_type": "", "tail_pos": []}]

41c5b6a9983a19b6331d8757798d2eeee55798dfc23bee123a78ec14c532dc8c

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Clofibrate - induced myopathy in patients with diabetes insipidus ."}

[{"head": "myopathy", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Clofibrate", "tail_type": "", "tail_pos": []}]

41de024c10894629b1671d2f5475b3c6986dc00f46d797d3955aa7f80d39ae1d

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "This is the first case of HBV reactivation occurring during the year following rituximab monotherapy in the absence of any other immunosuppressive factor ."}

[{"head": "HBV reactivation", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "rituximab", "tail_type": "", "tail_pos": []}]

34289d0d7929ec59049ccb94a2bc65ce544c16dac681aa629eadce1cac41e127

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Theophylline intoxication mimicking diabetic ketoacidosis in a child ."}

[{"head": "Theophylline intoxication", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Theophylline", "tail_type": "", "tail_pos": []}]

958b3fbecbd22e1842d95dbd3aee22756738ac54dd2fa413b4b233a1397ddc5e

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Four patients who manifested symptoms of the antiepileptic drug ( AED ) hypersensitivity syndrome during therapy with carbamazepine are reported ."}

[{"head": "hypersensitivity syndrome", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "carbamazepine", "tail_type": "", "tail_pos": []}]

9b17b097bcbc4460c055840cff4af1eb1a9a5af208369a16b64da8e7f80446f5

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "A 53-year - old man developed NMS without rigidity while taking olanzapine ."}

[{"head": "NMS", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "olanzapine", "tail_type": "", "tail_pos": []}]

e91133a73bdc9762fda179a4b4641ebc8bb49f6c9c5faa73615a180b01a45d9e

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "The authors describe pericardial hemorrhage , which is related to the use of low - dose acetylsalicylic acid in a patient with essential thrombocythemia ."}

[{"head": "pericardial hemorrhage", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "acetylsalicylic acid", "tail_type": "", "tail_pos": []}]

3aa3cddc173aeb5f154cf4f476b63760e503da52a08074f4e5459d5d89a28148

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Three of 50 patients treated with isotretinoin ( 1 mg / kg / day ) for cystic acne complained of poor night vision and/or excessive glare sensitivity ."}

[{"head": "excessive glare sensitivity", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "isotretinoin", "tail_type": "", "tail_pos": []}, {"head": "poor night vision", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "isotretinoin", "tail_type": "", "tail_pos": []}]

23e42b459d0005b34a9093995e04df74c6806f89015d439310ad4ca02e9f2c5d

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "When measured , the serum lithium level had increased 4-fold during acyclovir therapy ."}

[{"head": "serum lithium level had increased", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "acyclovir", "tail_type": "", "tail_pos": []}, {"head": "serum lithium level had increased", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "lithium", "tail_type": "", "tail_pos": []}]

049cc9267aa2c59b4263ed36f4fc9aaec4a07b87bed9cfc73c8cd1b72e783e44

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Alopecia , nausea , and vomiting were attributed to the cyclophosphamide component of the therapy ."}

[{"head": "Alopecia", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "cyclophosphamide", "tail_type": "", "tail_pos": []}, {"head": "nausea", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "cyclophosphamide", "tail_type": "", "tail_pos": []}, {"head": "vomiting", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "cyclophosphamide", "tail_type": "", "tail_pos": []}]

c7fe6da62dfefca82506a89faf61f11c8753cded02e3d59cd1b0047091cb2018

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "We report here a case of TEN after administration of ciprofloxacin ."}

[{"head": "TEN", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "ciprofloxacin", "tail_type": "", "tail_pos": []}]

cc3c42d2536a0dd705750d886c2e6d76ac603440a51032a16eacb0b67d5a3e57

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "We believe this is the first report of intrathecal diamorphine causing anaphylaxis ."}

[{"head": "anaphylaxis", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "diamorphine", "tail_type": "", "tail_pos": []}]

d8d6b73186514528c51cff1e618b7c19bbf3d90ff5b7d6918d6b2b01ce3f8656

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "A 35-year - old nephrotic man developed acute renal failure with serum creatinine to 1543 micromol / l after a month of therapy with enalapril ."}

[{"head": "acute renal failure", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "enalapril", "tail_type": "", "tail_pos": []}]

b331b9f0a571463f1922b397091eddd11e89d0c0b1c57ce13a71d400a111ed14

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Fluoxetine - related death in a child with cytochrome P-450 2D6 genetic deficiency ."}

[{"head": "death", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Fluoxetine", "tail_type": "", "tail_pos": []}]

777a8755fa72b35d6328bb0067165745eb20c29b144863396546b5d060fcade4

RE

ADE_corpus

{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Lithium neurotoxicity should be considered in Creutzfeldt - Jakob disease differential diagnosis , serial electroencephalograms being the most valuable ."}

[{"head": "Creutzfeldt - Jakob disease", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Lithium", "tail_type": "", "tail_pos": []}, {"head": "Lithium neurotoxicity", "head_type": "", "head_pos": [], "relation": "adverse effect", "tail": "Lithium", "tail_type": "", "tail_pos": []}]