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W592278124 | Principles of Emergency Management and Emergency Operations Centers (EOC) | Introduction Michael Fagel and Stephen Krill Types of Disasters Phases of Disaster Levels of Severity Why Plans Fail Planning As a Blueprint A Brief History of Emergency Management Authorities and Directives Response Plans Assessing Vulnerabilities James Peerenboom and Ron Fisher Vulnerability Assessment Critical Infrastructure and Key Resources (CIKR) Methodological Approaches to Vulnerability Assessment Simple Rating Risk Matrix Risk Equation Required Expertise Developing a Planning Team Michael Fagel The Emergency Planning Team Who Should Be on the Planning Team? Getting the Team Together Team Operation Stages of Team Formation Team Roles Characteristics of an Effective Team Responder Health and Safety Michael Steinle Defining Essential Personnel Response Scenarios and Associated Hazards Protection Programs and Systems Medical Protective Practices Disaster Preparedness and the Law Thomas Schneid The Questions The Answers The Potentially Applicable Laws Negligence Emergency Management Phases Stress Management and Responders K. R. Juzwin Why Stress Management Is Important to Emergency Managers Stress-Related Disorders Understanding Stress along the Continuum Stress Reactions Acute Stress Manager Responsibilities in a Critical Event Planning: Helping Take Care of Your Responders in Advance Suggestions for Supporting Your Responders Psychological First Aid Critical Incident Stress Management (CISM) Briefing and Debriefing Suggestions and Considerations Developing an Emergency Operations Plan (EOP) Michael Fagel Why a Jurisdiction Needs an EOP The Emergency Planning Process Components of an Emergency Operations Plan The Emergency Planning Team Disaster Preparedness and the Law Developing an Exercise Program Michael Fagel Why Exercise? Regulatory Requirements Exercise Functions The Comprehensive Exercise Program Who Participates in the Exercise Program? Activities Included in the Exercise Program Building an Exercise Program The Exercise Process Reviewing the Current Plan Assessing Capability to Conduct an Exercise Addressing Liabilities and Costs Gaining Support Assembling a Design Team Exercise Documents Three Types of Exercises Michael Fagel The Functional Exercise The Full-Scale Exercise Exercise Evaluation Postexercise Briefings Enhancements EOC Management and Operations Lucien Canton and Nicholas Staikos Facility Management Operational Management Organizing for EOC Management Operations Room Design ICS/EOC Interface Michael Fagel| EOC Management and Operations: Responsibilities Foundations for Establishing the Emergency Operations Center Using the EOP and Hazard Analysis to Design an EOC Developing Policies and Procedures Continuity of Operations Planning Chad Bowers The Foundation: Continuity Planning and Program Management Continuity Program Management Cycle Essential Functions Human Capital Continuity Teams and Leadership Orders of Succession Delegations of Authority Primary Facilities Alternate Facilities Vital Records/Vital Resources Devolution Reconstitution Testing, Training, and Exercising The Role of Business Continuity Management Robert Coullahan Context and Challenge: Critical Infrastructure Protection National Infrastructure Protection Plan (NIPP) Sector-Specific Plans Role of the Private Sector in Contemporary Emergency Operations Professional Practices of Business Continuity Management Enterprise Resilience Emergency Command Center: Mission, Roles, and Responsibilities Relationship with the Public Safety EOC Emerging Capabilities: State and Local Data Fusion Centers Public-Private Partnerships Appendices: Organizing for Homeland Security and Emergency Management Stephen Krill Managing Spontaneous Volunteers Michael Fagel Emergency Management and the Media Randall Duncan | publication |
W2253686266 | Establishment of Uropygial Gland Growth Curves for White, Three-Way Crossed Mule Ducklings | Growth curves for the uropygial gland (UG) of white, 3-way crossed mule ducklings were established using the Gompertz function. In total, 144 ducklings were fed in 12 floor pens with 12 birds in each pen. Each pen contained an equal number of animals of each sex. Feed and water were supplied ad libitum throughout the entire experimental period. The weekly change in UG weight was recorded in males and females from hatch to 8 weeks of age. The weight and length of the UG, the width of the lobus glandulae uropygialis, the length and width of the pluma of the circulus uropygialis, and the index of the papilla uropygialis were measured once a week in individual ducklings in one pen. The average UG weight gain observed in white, 3-way crossed drakes was significantly higher than that of ducks of 21-56 days of age (P < 0.05). The UG length was 1.64-2.23 times the width of the left or right lobe, and the development of the UG was delayed from 3-4 weeks of age. The morphology of the UG changed from elliptical to elongated-elliptical with age. The right and left lobus glandulae uropygialis were symmetrical. The Gompertz growth functions of the UG in drakes and ducks were W=5.49e -e-0.675(t-1.955) and W=4.76e -e-0.685(t-1.936), respectively, where t represents age in weeks. These equations indicated that the maximum growth rate for drakes occurred at 14.1 days of age and for ducks at 13.6 days of age. | publication |
W1529782501 | Abstract 153: High neuropilin-1 expression on monocytes is positively associated with trastuzumab-mediated antibody-dependent cellular cytotoxicity of the HER2-overexpressing breast cancer cell line | Purpose Neuropilin-1 (Nrp1) was initially characterized as a guide for migrating cells and axons in developing nervous systems and is essential for the precise formation of neurons and vasculature. However, it was recently reported to also play an important role in the immune system. This study aimed to investigate the role of Nrp1 on monocytes in trastuzumab-mediated antibody-dependent cellular cytotoxicity (ADCC) targeting the HER2-positive human breast cancer cell line SKBR3. In addition, we evaluated the gene expression profile of monocytes expressing high and low levels of Nrp1. Methods Peripheral blood mononuclear cells from healthy volunteers were prepared using BD Vacutainer CPT Cell Preparation Tubes. The cells were stained with fluorescein isothiocyanate-conjugated anti-CD14 and allophycocyanin-conjugated anti-Nrp1 antibodies, and Nrp1high and Nrp1low monocyte subsets were sorted using FACSAria. These cells were used as effector cells in a conventional ADCC assay with SKBR3 as target cells and trastuzumab as the antibody. Target cell cytotoxicity was measured using the LDH cytotoxic test kit. The effector cell to target cell ratios of 20:1 and 10:1 were used. Gene expression analysis was performed by Affymetrix GeneChip microarrays. All study protocols were approved by the Ethics Committee for Clinical Research, Kyoto University Hospital, Kyoto, Japan (authorization number G424). Results The LDH cytotoxic test revealed significantly higher target cancer cell cytotoxicity in sorted Nrp1high monocytes than in Nrp1low monocytes (75% vs. 45%, p Conclusion These results suggest that determination of Nrp1 expression can be used to classify monocytes as populations with and without cellular cytotoxic activity. Analysis of Nrp1 expression levels in monocytes can therefore be used to identify HER2-positive breast cancer patients for whom trastuzumab therapy will be less effective. Citation Format: Kosuke Kawaguchi, Eiji Suzuki, Masao Kawashima, Masakazu Toi. High neuropilin-1 expression on monocytes is positively associated with trastuzumab-mediated antibody-dependent cellular cytotoxicity of the HER2-overexpressing breast cancer cell line. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 153. doi:10.1158/1538-7445.AM2014-153 | publication |
W2106163092 | DNA transfection of bone marrow mesenchymal stem cells using micro electroporation chips | Experimental study of electroporation of bone marrow mesenchymal stem cells (MSCs) at the single-cell level was carried out on a micro EP chip by using single electric rectangular pulse. The threshold values of the electrode potential and pulse width for gas bubble generation on the micro electrodes due to electrolysis of water were revealed as 4.5 volt and 100 μs, respectively. Quantitative EP study was performed with various electric field strengths for various pulse widths, ranging from 20 μs to 15 ms. Over 1,000 single-cell EP results were used to construct an EP “phase diagram”, which delineates the boundaries for (1) effective EP of MSCs and (2) electric cell lysis of MSCs. Finally, the micro EP chip showed successful transfection of the pEGFP-C1 plasmid into the MSCs by properly choosing the electric parameters from the EP “phase diagram”. | publication |
W2980229124 | Applying Deep Learning to the Cache Replacement Problem | Despite its success in many areas, deep learning is a poor fit for use in hardware predictors because these models are impractically large and slow, but this paper shows how we can use deep learning to help design a new cache replacement policy. We first show that for cache replacement, a powerful LSTM learning model can in an offline setting provide better accuracy than current hardware predictors. We then perform analysis to interpret this LSTM model, deriving a key insight that allows us to design a simple online model that matches the offline model's accuracy with orders of magnitude lower cost. The result is the Glider cache replacement policy, which we evaluate on a set of 33 memory-intensive programs from the SPEC 2006, SPEC 2017, and GAP (graph-processing) benchmark suites. In a single-core setting, Glider outperforms top finishers from the 2nd Cache Replacement Championship, reducing the miss rate over LRU by 8.9%, compared to reductions of 7.1% for Hawkeye, 6.5% for MPPPB, and 7.5% for SHiP++. On a four-core system, Glider improves IPC over LRU by 14.7%, compared with improvements of 13.6% (Hawkeye), 13.2% (MPPPB), and 11.4% (SHiP++). | publication |
US 0307430 W | CLONING OF CYTOCHROME P450 GENES FROM NICOTIANA | The present invention relates to P450 enzymes and nucleic acid sequences encoding P450 enzymes in Nicotiana, and methods of using those enzymes and nucleic acid sequences to alter plant phenotypes. | patent |
W2593873339 | Instruction manual for the <scp>ILAE</scp> 2017 operational classification of seizure types | This companion paper to the introduction of the International League Against Epilepsy (ILAE) 2017 classification of seizure types provides guidance on how to employ the classification. Illustration of the classification is enacted by tables, a glossary of relevant terms, mapping of old to new terms, suggested abbreviations, and examples. Basic and extended versions of the classification are available, depending on the desired degree of detail. Key signs and symptoms of seizures (semiology) are used as a basis for categories of seizures that are focal or generalized from onset or with unknown onset. Any focal seizure can further be optionally characterized by whether awareness is retained or impaired. Impaired awareness during any segment of the seizure renders it a focal impaired awareness seizure. Focal seizures are further optionally characterized by motor onset signs and symptoms: atonic, automatisms, clonic, epileptic spasms, or hyperkinetic, myoclonic, or tonic activity. Nonmotor-onset seizures can manifest as autonomic, behavior arrest, cognitive, emotional, or sensory dysfunction. The earliest prominent manifestation defines the seizure type, which might then progress to other signs and symptoms. Focal seizures can become bilateral tonic-clonic. Generalized seizures engage bilateral networks from onset. Generalized motor seizure characteristics comprise atonic, clonic, epileptic spasms, myoclonic, myoclonic-atonic, myoclonic-tonic-clonic, tonic, or tonic-clonic. Nonmotor (absence) seizures are typical or atypical, or seizures that present prominent myoclonic activity or eyelid myoclonia. Seizures of unknown onset may have features that can still be classified as motor, nonmotor, tonic-clonic, epileptic spasms, or behavior arrest. This "users' manual" for the ILAE 2017 seizure classification will assist the adoption of the new system. | publication |
224116 | Climate sensitivity of glacial landscape dynamics | How do erosion rates in glacial landscapes vary with climate change and how do such changes affect the dynamics of mountain glaciers? Providing quantitative constraints towards this question is the main objective of COLD. These constraints are so important because mountain glaciers are sensitive to climate change and their deposits provide a unique history of Earths terrestrial climate that allows reconstructing leads and lags in the climate system.
The climate sensitivity of mountain glaciers is influenced by debris on their surface that impedes ice melting. Theoretical models of frost-related bedrock fracturing predict that rates of debris production are temperature-sensitive and that its supply to mountain glaciers increases during warming periods. Thus a previously unrecognized negative feedback emerges that lowers ice melt rates and potentially buffers part of the ice retreat due to warming. However, the temperature-sensitivity of debris production in glacial landscapes is poorly understood. Specifically, we lack robust erosion rate estimates for these landscapes, which are key for testing models of frost-related bedrock fracturing.
Here, I propose an innovative combination of new tools that capitalize on recent developments in cosmogenic nuclide geochemistry, landscape evolution modelling, and planetary-scale remote sensing analysis. I will use these tools to quantify headwall erosion rates in mountainous glacial landscapes and to gauge the sensitivity of mountain glaciers to variations in debris supply. Expected results will provide a basis for assessing the impacts of global warming, for improved predictions of valley glacier evolution, and for palaeoclimate interpretations of glacial landforms. COLD will focus on glacial landscapes, but the inverse modelling approach I will develop is applicable to any landscape on Earth and has the potential to fundamentally transform how we use cosmogenic nuclides to constrain Earth surface dynamics. | project/european |
W2353767404 | Grain-size Characteristics of Sand Materials in Tamarix Cone Sedimentary Veins and Wind Sandy Environment Change in the Southern Region of Taklimakan Desert | The clear sedimentary veins of Tamarix Cone,can not only date the age,but also has important instruction significance to restore regional historical climate environment.This paper selects three sample points′grain size parameters,sand material anomaly values and Sahu discriminant function which are in Tamarix Cone sand materials in the south margin of Taklimakan Desert.We combined with the software of calculation and analysis such as SPSS 17.0,Sigma Plot and Excel 2007,aimed to restore the region hundreds years of wind sandy environment changes.The analysis results of sand material grain size characteristics we got are as followings.The sand transport power of sample point B is the strongest,and the sedimentary materials are dominated by saltating and slow-moving,which means that the sedimentary environment of the sample point B is more stable.On the other hand,sample point C of deposition is given priority to with suspended matter.Through the sample points location relations and determination,the Tamarix Cone of this region mainly consists of eolian sand.The sand material granularity sequences show that the region climate gradually from drought to wet in two hundred of years.The change phase of wind sandy environment includes that the weaker wind-sandy action was from 1801to 1872;the significantly stronger action was from 1872to 1902;the normal strength was from 1903to 1984;the significant decline of wind-sandy action was from 1985to 2010. | publication |
176842 | Myrrha research and transmutation endeavour | The Strategic Research Agenda of the EU Sustainable Nuclear Energy Technical platform requires new large infrastructures for its successful deployment. MYRRHA has been identified as a long term supporting research facility for all ESNII systems and as such put in the high-priority list of ESFRI. The goal of MYRTE is to perform the necessary research in order to demonstrate the feasibility of transmutation of high-level waste at industrial scale through the development of the MYRRHA research facility. Within MYRRHA as a large research facility, the demonstration of the technological performance of transmutation will be combined with the use for the production of radio-isotopes and as a material testing for nuclear fission and fusion applications. Numerical studies and experimental facilities are foreseen to reach this goal.
Besides coordination, international collaboration and dissemination activities, the MYRTE proposal contains 5 technical work packages. The first and largest work-package is devoted to the realisation of the injector part of the MYRRHA accelerator to demonstrate the feasibility and required reliability of this non-semi-conducting part of the accelerator. The second work-package addresses the main outstanding technical issues in thermal hydraulics by numerical simulations and experimental validation. Pool thermal hydraulics and thermal hydraulics of the fuel assembly will be the focus of this WP. In the WP on LBE Chemistry, the evaporation from LBE, capture and deposition of Po and fission products will be studied in detail to complement the safety report. A small dedicated WP on experimental reactor physics is also foreseen to allow carrying out the necessary supplementary experiments at the GUINEVERE-facility to address the questions of the safety authorities. In a last WP, advanced studies on Americium-bearing oxide fuel are carried out to demonstrate the capability of developing minor actinide fuel for transmutation. | project/european |
W577884598 | Evaluation of HSDPA and LTE | This book explains how the performance of modern cellular wireless networks can be evaluated by measurements and simulations With the roll-out of LTE, high data throughput is promised to be available to cellular users. In case you have ever wondered how high this throughput really is, this book is the right read for you: At first, it presents results from experimental research and simulations of the physical layer of HSDPA, WiMAX, and LTE. Next, it explains in detail how measurements on such systems need to be performed in order to achieve reproducible and repeatable results. The book further addresses how wireless links can be evaluated by means of standard-compliant link-level simulation. The major challenge in this context is their complexity when investigating complete wireless cellular networks. Consequently, it is shown how system-level simulators with a higher abstraction level can be designed such that their results still match link-level simulations. Exemplarily, the book finally presents optimizations of wireless systems over several cells. This book: * Explains how the performance of modern cellular wireless networks can be evaluated by measurements and simulations * Discusses the concept of testbeds, highlighting the challenges and expectations when building them * Explains measurement techniques, including the evaluation of the measurement quality by statistical inference techniques * Presents throughput results for HSDPA, WiMAX, and LTE * Demonstrates simulators at both, link- level and system-level * Provides system-level and link-level simulators (for WiMAX and LTE) on an accompanying website (https://www.nt.tuwien.ac.at/downloads/featured-downloads) This book is an insightful guide for researchers and engineers working in the field of mobile radio communication as well as network planning. Advanced students studying related courses will also find the book interesting. | publication |
W2023290413 | Statistical analysis of community response to low amplitude sonic boom noise | The Waveform and Sonicboom Perception and Response (WSPR) Program conducted a field study of subjective response to noise from multiple low-amplitude sonic booms. The team was led by Wyle and included researchers from Penn State, Tetra Tech and Gulfstream Aerospace Corp. The test exposed residents in the Edwards Air Force Base (EAFB) Housing area to two weeks of low-amplitude sonic booms while recording their responses via surveys. There were 52 participants divided across three response modes. The response instruments included Baseline Surveys, Single Event Surveys submitted each time a participant heard a boom, and Daily Surveys submitted at the end of each day. The analysis included assessments of single events and cumulative daily ratings of annoyance and categorical variables including loudness, interference, startle, vibration, and rattle. The WSPR daily annoyance data was analyzed by computing percent highly annoyed (%HA) and relating it to the cumulative noise exposure and by relating the subjective annoyance rating directly to the daily noise exposure. The WSPR design was established to cover the full range of noise exposures and annoyance factors so that sufficient data would be gathered to facilitate analyses of %HA and noise metrics. The statistical analyses examining these relationships will be presented. | publication |
2728916 | Turn cancer immunotherapy effective in most patients | Stimunity is a company that develops disruptive immuno-stimulatory biological drugs to restore the immune system against tumor cells.
Immune checkpoint inhibitors showed great potential in cancer immunotherapy after achieving 5-year survival rates for patients with advanced or metastatic cancers, unseen by physicians before. This is a promising beginning. Nevertheless, 5 million patients worldwide remain unresponsive to immunotherapy and do not have any other therapeutic option. On average it represents 50% of all cancers.
A promising answer to this problem is the development of new drugs that activate the STING (STimulator of INterferon Genes) pathway, which fires up the innate immune system of these unresponsive patients, inducing a potent and durable anti-tumour immune response. It is expected to be effective on a much larger number of cancer patients.
Stimunity’s first product, named STI-001, restores weakened immune systems to kill tumour cells. It is especially effective on distant tumours. Competitors using chemical STING ligands have shown a much weaker immune response than STI-001. STI-001 is based on a safe cutting-edge Virus-Like Particle (VLP) technology that encapsulates the best-known natural STING ligand and efficiently deliver it into immune cells.
There is high interest in STI-001, as demonstrated by public and private funding (raised €2.2M to date) and advanced discussions with major pharmaceutical companies (see Letters of Intent).
SMEi1 project will allow Stimunity to i) confirm the technical feasibility of manufacturing STI-001, (ii) update the FTO, (iii) assess regulatory issues, (iv) validate the marketing and business plan.
Our long-term goal is to develop a pipeline of products based on proprietary VLPs in cancer immunotherapy and create a long term out-licensing strategy as a worldwide leader in VLP-based immunotherapy. | project/european |
W1969982854 | A fast partial Fourier transform (FPFT) for data compression and filtering | A discrete Fourier transform (DFT) or the closely related discrete cosine transform (DCT) is often employed as part of a
data compression scheme. This paper presents a fast partial Fourier transform (FPFT) algorithm that is useful for
calculating a subset of M Fourier transform coefficients for a data set comprised of N points (M < N). This algorithm
reduces to the standard DFT when M = 1 and it reduces to the radix-2, decimation-in-time FFT when M = N and N is a
power of 2. The DFT requires on the order of MN complex floating point multiplications to calculate M coefficients for
N data points, a complete FFT requires on the order of (N/2)log 2 N multiplications independent of M, and the new FPFT
algorithm requires on the order of (N/2)log 2 M + N multiplications. The FPFT algorithm introduced in this paper could
be readily adapted to parallel processing. In addition to data compression, the FPFT algorithm described in this paper
might be useful for very narrow band filter operations that pass only a small number of non-zero frequency coefficients
such that M << N. | publication |
W4213434147 | Direct detection of dark matter—APPEC committee report* | This report provides an extensive review of the experimental programme of direct detection searches of particle dark matter. It focuses mostly on European efforts, both current and planned, but does it within a broader context of a worldwide activity in the field. It aims at identifying the virtues, opportunities and challenges associated with the different experimental approaches and search techniques. It presents scientific and technological synergies, both existing and emerging, with some other areas of particle physics, notably collider and neutrino programmes, and beyond. It addresses the issue of infrastructure in light of the growing needs and challenges of the different experimental searches. Finally, the report makes a number of recommendations from the perspective of a long-term future of the field. They are introduced, along with some justification, in the opening overview and recommendations section and are next summarised at the end of the report. Overall, we recommend that the direct search for dark matter particle interactions with a detector target should be given top priority in astroparticle physics, and in all particle physics, and beyond, as a positive measurement will provide the most unambiguous confirmation of the particle nature of dark matter in the Universe. | publication |
W1757164770 | Linear Network Coding, Linear Index Coding and Representable Discrete Polymatroids | Discrete polymatroids are the multi-set analogue of matroids. In this paper, we explore the connections among linear network coding, linear index coding, and representable discrete polymatroids. We consider the vector linear solutions of networks over a field $\mathbb {F}_{q}$ , with possibly different message and edge vector dimensions, which are referred to as linear fractional solutions. It is well known that a scalar linear solution over $\mathbb {F}_{q}$ exists for a network if and only if the network is matroidal with respect to a matroid representable over $\mathbb {F}_{q}$ . We define a discrete polymatroidal network and show that a linear fractional solution over a field $\mathbb {F}_{q}$ exists for a network if and only if the network is discrete polymatroidal with respect to a discrete polymatroid representable over $\mathbb {F}_{q}$ . An algorithm to construct the networks starting from certain class of discrete polymatroids is provided. Every representation over $\mathbb {F}_{q}$ for the discrete polymatroid, results in a linear fractional solution over $\mathbb {F}_{q}$ for the constructed network. Next, we consider the index coding problem, which involves a sender, which generates a set of messages $X=\{x_{1},x_{2},\dotso x_{k}\}$ , and a set of receivers $\mathcal {R}$ , which demand messages. A receiver $R \in \mathcal {R}$ is specified by the tuple $(x,H)$ , where $x \in X$ is the message demanded by $R$ and $H \subseteq X \!\setminus \! \{x\}$ is the side information possessed by $R$ . We first show that a linear solution to an index coding problem exists if and only if there exists a representable discrete polymatroid, satisfying certain conditions, which are determined by the index coding problem considered. Rouayheb et al. showed that the problem of finding a multi-linear representation for a matroid can be reduced to finding a perfect linear index coding solution for an index coding problem obtained from that matroid. The multi-linear representation of a matroid can be viewed as a special case of representation of an appropriate discrete polymatroid. We generalize the result of Rouayheb et al. , by showing that the problem of finding a representation for a discrete polymatroid can be reduced to finding a perfect linear index coding solution for an index coding problem obtained from that discrete polymatroid. | publication |
W2325291292 | The contribution of gravity method in geothermal exploration of southern part of the Gulf of Suez–Sinai region, Egypt | Abstract The Gulf of Suez region represents the most promising area in Egypt for geothermal exploration which is characterized by superficial thermal manifestations represented by a cluster of hot springs with varying temperatures from 35 to 72 °C. The main purpose of the present study was to shed the light on the integration between gravity work and geothermal data in detecting the main subsurface structures in addition to expecting the geothermal sources in the area under consideration. Correction was applied on the bottom hole temperature data to obtain the true formation equilibrium temperatures that can provide useful information about the subsurface thermal regime. Based on these logging data, temperature gradient and heat flow values were computed at each well, and it is found that the mean geothermal gradient of the study area is 32 °C/km; nevertheless, some local geothermal potential fields were located with more than 40 °C/km. Also, heat flow values are ranging from 45 to 115 mW/m 2 . The Bouguer anomaly map of the study area was used for delineating the subsurface structures and tectonic trends that have resulted in a potential heat source. The gravity inversion revealed a good correlation between areas of high temperature gradients, high heat flow and positive gravity anomalies. The high temperature gradient and heat flow values suggested being associated with a noticeable hydrothermal source of heat anomaly located at relatively shallow depths which is expected to be due to the uplift of the basement in the area. | publication |
174525 | Quantiative study of major historic epidemics and transitions to longer, healthier lives | Only 150 years ago, one in five Europeans died in infancy, life expectancy was 40 years, and the leading causes of death were infectious diseases: tuberculosis, smallpox, measles, pertussis, diphtheria, cholera, typhoid fever, scarlet fever. But in just a few decades beginning about 1880, life expectancy rose dramatically as infectious disease mortality plummeted. This “2nd epidemiologic transition”, in which chronic diseases began replacing infections as leading causes of death, occurred well in advance of antibiotics and most vaccines. Many factors have been proposed to explain it, including improved nutrition, sanitation, clean drinking water, better housing and the emergence of social support systems.
Little has been done, however, to systematically rescue and quantitatively study historic health data and rigorously investigate the epidemiologic transition. I lay out here an ambitious, novel, interdisciplinary and feasible proposal to do just that. In the process, I will broaden my research scope from statistical modeling of historic pandemic influenza to all historic infections, understand the historical context in which the transition occurred, and master new concepts in dynamic disease modeling. Danish historic medical data are uniquely detailed and reach far back in time, and are uniquely suited for quantitative studies of long time series of morbidity and mortality, with the promise to further illuminate the epidemiology of important diseases including smallpox, cholera, and measles.
After 25 years abroad as a senior researcher at the National Institutes of Health and Professor of Global Health in the U.S., I now wish to return to my native Denmark. I had the honor this year to be elected to the Royal Danish Academy of Sciences and Letters, and receive funding to be a visiting professor at the University of Copenhagen, and trust this signals the beginning of my successful re-integration to European academia. | project/european |
W1789319802 | Characteristics and Significance of Residential Density and Energy Consumption in Surabaya, Indonesia | Residential activities have significant impact on energy use. Those activities vary among residential densities. Surabaya classified its city density into three category, those are low, medium and high. This paper aims to explore the characteristics and significance of residential density and energy consumption in Surabaya City, Indonesia. The selected study areas were chosen from the classification of population density based on Surabaya Spatial Plan. The first step of this research is to calculate the energy consumption in each residential density. The next step is to analyze the significant correlation of residential density attributes and energy consumption. The result showed significance difference in five residential characteristics, in terms of number of vehicle ownership, housing ventilation, electricity use, cooking fuel use and use of electronic devices. | publication |
W2019522723 | Segmentation of malignant gliomas through remote collaboration and statistical fusion | Malignant gliomas represent an aggressive class of central nervous system neoplasms. Correlation of interventional outcomes with tumor morphometry data necessitates 3D segmentation of tumors (typically based on magnetic resonance imaging). Expert delineation is the long-held gold standard for tumor segmentation, but is exceptionally resource intensive and subject to intrarater and inter-rater variability. Automated tumor segmentation algorithms have been demonstrated for a variety of imaging modalities and tumor phenotypes, but translation of these methods across clinical study designs is problematic given variation in image acquisition, tumor characteristics, segmentation objectives, and validation criteria. Herein, the authors demonstrate an alternative approach for high-throughput tumor segmentation using Internet-based, collaborative labeling.In a study of 85 human raters and 98 tumor patients, raters were recruited from a general university campus population (i.e., no specific medical knowledge), given minimal training, and provided web-based tools to label MRI images based on 2D cross sections. The labeling goal was characterized as to extract the enhanced tumor cores on T1-weighted MRI and the bright abnormality on T2-weighted MRI. An experienced rater manually constructed the ground truth volumes of a randomly sampled subcohort of 48 tumor subjects (for both T1w and T2w). Raters' taskwise individual observations, as well as the volume wise truth estimates via statistical fusion method, were evaluated over the subjects having the ground truth.Individual raters were able to reliably characterize (with >0.8 dice similarity coefficient, DSC) the gadolinium-enhancing cores and extent of the edematous areas only slightly more than half of the time. Yet, human raters were efficient in terms of providing these highly variable segmentations (less than 20 s per slice). When statistical fusion was used to combine the results of seven raters per slice for all slices in the datasets, the 3D agreement of the fused results with expertly delineated segmentations was on par with the inter-rater reliability observed between experienced raters using traditional 3D tools (approximately 0.85 DSC). The cumulative time spent per tumor patient with the collaborative approach was equivalent to that with an experienced rater, but the collaborative approach could be achieved with less training time, fewer resources, and efficient parallelization.Hence, collaborative labeling is a promising technique with potentially wide applicability to cost-effective manual labeling of medical images. | publication |
US 9928963 W | LOW PRESSURE RATIO PISTON COMPRESSOR | A reciprocating compressor capable of producing a steady-state, continuous, non-pulsing outflow at volumes less than 25 gallons per hour. The compressor utilizes at least two pistons driven in a near axial manner with any lateral forces imparted to the compressor subsequently removed. The compressor is useful in a vapor compression distillate system but could also be adapted to pump liquids. A rotating cam is provided which through cam followers drives the pistons such that the compression stroke of one compensates for the vibrational force introduced into the apparatus by another piston caused by change in that piston's direction. | patent |
W4312278998 | Bailando con gigantes | Reseña del libro de Sonia Le Gouriellec, Djibouti: la diplomátie de géant d´un petit État, Villeneuve d´Asq, Presses universitaires du Septentrion, 2020
 | publication |
W1966144805 | The impact of class absenteeism on undergraduates’ academic performance: evidence from an elite Economics school in Portugal | The empirical literature focusing mainly on the USA suggests that class absenteeism undermines students’ academic performance and that an enforced mandatory attendance policy may be beneficial. Based on a different cultural and economic context, and using data on 146 second-year management students enrolled in a macroeconomics course at an elite economics school in Portugal, it is shown that even when controlling for potential endogenous factors associated with attendance and academic performance, absenteeism considerably lowers the students’ final grade (about 2 points in a 0–20-point grading scheme). In addition, it is established that a compulsory, though flexible, attendance policy contributes to improving students’ academic performance. | publication |
PT 2011000020 W | RECYCLABLE COATED FABRIC, BASED ON POLYOLEFIN MATERIALS, FOR USE AS DIGITAL PRINTING MEDIA | The present invention relates to a recyclable-coated fabric for using in digital printing applications. It is characterized for being processed with direct coating of a textile support with one or more layers of aqueous dispersions based on polyolefins, where different additives could be added by agitation; A finishing treatment consisting in primers and lacquers are then applied on top of the coated layers in order to improve its surface properties. | patent |
W2487821269 | Equipment in Mud Circulating Systems | This chapter provides a brief introduction to the equipment in the mud circulating system. Mud pumps serve as the heart of the mud circulating system. Reciprocating piston pumps are widely used for drilling oil and gas wells. The contaminant-removal equipment can include shale shakers, degassers, hydrocyclones, and centrifuges. An integrated unit of desanders and desilters is called a mud cleaner. The two types of piston strokes are the single-action piston stroke and the double-action piston stroke. A pump that has double-action strokes in two cylinders is called a duplex pump. Normally, duplex pumps can handle higher flow rates, and triplex pumps can provide higher working pressure. However, for a given pump of fixed horsepower, the flow rate and working pressure can be adjusted by changing the sizes of the liners inside the pump. Three types of drill bits are used in the oil and gas industry: drag bits, cone bits, and PDC bits. | publication |
3736457 | Transition metal carbides as efficient catalysts for methane partial oxidation | Methane is a particularly problematic greenhouse gas as its impact is 25 times greater than carbon dioxide over a 100-year period. Human activity has increased the amount of methane in the atmosphere, contributing to climate change. Therefore, there is an imperative for the transformation of methane into useful chemicals. At this time, the most economically available route for the conversion of methane into more valuable chemicals is via synthesis gas, a mixture of CO and H2. The only large-scale process for natural gas conversion involves a reaction known as methane-steam reforming. However, it is an endothermic process that requires high operating temperatures. Methane partial oxidation (MPO) is a promising energy saving alternative because it does not require the use of superheated steam. A major goal is to find a catalyst that exhibits high activity, selectivity and stability at the relevant reaction conditions.
This project envisions the computational prediction of novel MPO catalysts that overcome this challenges by computationally screening a large set of materials consisting of precious metals (Rh, Pd, Pt, Au) and more affordable metals (Co, Ni, Cu) supported on transition metal carbides (TMCs, TM = Ti, Zr, Hf, V, Nb, Ta, Mo, W). These type of catalysts have exhibited outstanding performance in other chemical reactions in the past 5 years. To this end, state-of-the-art Density Functional Theory and Kinetic Monte Carlo frameworks will be employed to provide direct predictions of activity, selectivity, stability and yield for the most promising catalysts at relevant reaction conditions. Moreover, the large amount of results gathered from this project will serve as a big dataset to conduct descriptor analysis, and will suggest key properties that correlate well with their activity for C-H and O-H bond activation. The results obtained will be discussed with our experimental collaborators, who will prepare a selected set of catalysts based on my findings. | project/european |
W2002995036 | A multi-path progression model for synchronization of arterial traffic signals | To contend with congestion and spillback on commuting arterials, serving as connectors between freeway and surface-street flows, this paper presents three multi-path progression models to offer progression bands for multiple critical path-flows contributing to the high volume in each arterial link. The first proposed model is a direct extension of MAXBAND under a predetermined phasing plan, but using the path-flow data to yield the progression bands. The second model further takes the phase sequence at each intersection as a decision variable, and concurrently optimizes the signal plans with offsets for the entire arterial. Due to the competing nature of multi-path progression flows over the same green duration, the third model is proposed with a function to automatically select the optimal number of paths in their bandwidths maximization process. The results of extensive simulation studies have shown that the proposed models outperform conventional design methods, such as MAXBAND or TRANSYT, especially for those arterials with multiple heavy path-flows. The research results from this study have also reflected the need to collect more traffic pattern data such as major path-flow volumes, in addition to the typical intersection volume counts. | publication |
2729468 | Horizon 2020: h2020-sga-infra-geant-2018 topic [b] increase of long-term backbone capacity | The GN4 Phase 3 Network (GN4-3N) proposal for part b of the third Specific Grant Agreement (SGA3(b) is made in response to the H2020-SGA-INFRA-GEANT-2018 (Topic [b] Research and Education Networking) call, received 17 October 2018, under the 68-month Framework Partnership Agreement (FPA) established between the GÉANT Consortium and the European Commission in April 2015. It is proposed to last 48 months to implement, as the call requests, a very ambitious restructuring of the backbone network operated by GÉANT in order to provide equal access to clouds and other e-infrastructure services in the European research area and beyond. It will improve the overall resilience and reliability of the GÉANT network significantly and offer a base for future improvements in access, transmission speeds and capacity wherever needed.
The outcome of GN4-3N project will offer uniform network access and choice of services to many more partners, eliminating the ""digital divide"" wherever technically and economically feasible.
This project proposal is based on technical and economic studies carried out during 2017-2018 in the GN4-2 project which have given the Consortium clarity on the resourcing, financial and effort, needed to realise the huge ambition of this undertaking. It exclusively covers the engineering, procurement, acquisition and installation of the new backbone network. The day-to-day network operations as the elements of it is commissioned is the responsibility of the teams described in accompanying the GN4-3 project.
The GN4-3 and GN4-3N proposals are intimately connected through common teams and the technical, management and procurement expertise built-up over previous GN projects. This is what makes this ambitious proposal realistic. GN4-3N and GN4-3 have simply had to be proposed as distinct projects, due to the different funding model (with no depreciation) to be used in GN4-3N project. | project/european |
W895517819 | Abstract P4-08-01: Assessing the safety and feasibility of efficient hypothesis testing in patients with metastatic triple negative breast cancer | We hypothesize that new insights into how cancers progress and respond to treatment will come from clinical trials that i) extensively characterize the molecular features of a patient’s cancer; ii) use results to predict drug susceptibilities; iii) treat in accordance with these predictions; and iv) learn from individual patient outcomes to iterate and improve over time. To investigate the feasibility of this type of clinical study, we launched the Intensive Trial of OMics in (ITOMIC) for patients with metastatic triple negative breast cancer (TNBC) (Clinicaltrials.gov ID: NCT01957514). Eligible patients have metastatic TNBC, are platinum-naive, and are scheduled to receive Cisplatin. Biopsies are performed under carefully controlled conditions prior to Cisplatin – starting all subjects on a common treatment path, and uncoupling the time needed for specimen analysis from immediate therapy. Biopsies are repeated upon completion of Cisplatin and following subsequent therapies. A subset of specimens is chosen for whole Exome Sequencing, deep sequencing of a panel of cancer associated genes, and RNA-sequencing. De-identified results are placed on a web-based server for analysis and discussed at a meeting of the ITOMIC tumor board. A report describing results and potential therapies is provided to the subject’s oncologist. Treatment decisions are left to the discretion of the oncologist. If a decision is taken to pursue treatments identified in our report we offer assistance in accessing those treatments. Ten patients have been screened and seven have enrolled. Subjects range in age from 40 to 77 years and all but one has received extensive prior treatment for metastatic TNBC. All seven underwent an initial set of biopsies, targeting between two and five metastatic sites. For most metastatic sites, multiple core needle passes are performed. All subjects tolerated the biopsies well without significant adverse events, and all started treatment with Cisplatin. Three subjects completed Cisplatin and underwent a second round of biopsies. Potential targets for therapy were identified in 5 of the first 6 subjects, and three subjects have received four predicted therapies: 1) a patient with somatic loss of BRCA1 and two linked FGFR2 activating mutations, who was treated first with Veliparib through a single-patient IND and then switched to Ponatinib which produced a partial response; 2) a patient with a novel missense ROS1 mutation treated with crizotinib; and 3) a patient with CYP3A4 copy gain treated with cyclophosphamide. Conclusion: Our early experience indicates that this approach is feasible and may increase the efficiency of learning from patients with advanced cancer. Citation Format: C Anthony Blau, Colin Pritchard, Michael O Dorschner, Sibel Blau, Brigham Mecham, Elisabeth Mahen, VK Gadi, Wayne Monsky, Kimberly Burton, Arturo Ramirez, Jackie Stilwell, Eric Kladjian, Carol Collins, Jeannine S McCune, William S Noble, Julie Gralow, Frank Senecal, Linda Dhaene, Nicole Kuderer, Jennifer Specht, Chaozhong Song, Carla Grandori, Nathan Price, Mary Goldman, Aime Radenbaugh, David Haussler, Jingchun Zhu. Assessing the safety and feasibility of efficient hypothesis testing in patients with metastatic triple negative breast cancer [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P4-08-01. | publication |
3740865 | Low-Regularity and high oscillations: numerical analysis and computation of dispersive evolution equations | Partial differential equations (PDEs) play a central role in mathematics, allowing us to describe physical phenomena ranging from ultra-cold atoms (Bose–Einstein condensation) up to ultra-hot matter (nuclear fusion), from learning algorithms to fluids in the human brain. To understand nature we have to understand their qualitative behavior: existence and long time behavior of solutions, their geometric and dynamical properties – as well as to compute reliably their numerical solution. While linear problems and smooth solutions are nowadays well understood, a reliable description of ‘non-smooth’ phenomena remains one of the most challenging open problems in computational mathematics since the underlying PDEs have very complicated solutions exhibiting high oscillations and loss of regularity. This leads to huge errors, massive computational costs and ultimately provokes the failure of classical schemes. Nevertheless, ‘non-smooth phenomena’ play a fundamental role in modern physical modeling (e.g., blow-up phenomena, turbulences, high frequencies, low dispersion limits, etc.) which makes it an essential task to develop suitable numerical schemes. The overall ambition of LAHACODE is to make a crucial step towards closing this gap – addressing the fundamental question: How and to what extent can we reproduce the qualitative behavior of differential equations in a finite (discretized) world? LAHACODE is situated at the challenging frontiers of analysis and numerics. The main objective is to develop a novel class of numerical schemes for nonlinear PDEs with strong geometric structure at low regularity and high oscillations. The key idea in the construction of the new schemes is to tackle and deeply embed the underlying structure of resonances in the numerical discretizations. As in the continuous case, these terms are central to structure preservation, and provide the new schemes with remarkable properties – allowing reliable approximations where classical schemes fail. | project/european |
W1769507264 | Collecting History Imprints from Russia in the Age of the New Official Historiographic Agenda | The selection and acquisition of contemporary research-quality Russian and Soviet history imprints from Russia is presenting increasingly formidable challenges for institutions with mandates to collect and preserve this category of material. This situation promises to worsen, as, increasingly, the administration of the Russian Federation appears to be preparing to enforce an official historiographic agenda. The agenda, inferred over the past several years by many professional observers and interpreters of the Russian administration’s words and deeds, is to promote a view of the country’s twentieth-century history which reactivates World War II-era nationalist narratives, justifies a centralized authoritarian model of government, and cultivates a sense of estrangement from the West. Anticipating that high-level historical scholarship on particular aspects of Russian history might become an endangered genre in the Russian publishing arena—and that such publications might become increasingly difficult to ide... | publication |
W2016479318 | Study of the effects of surface modification by thermal shock method on photocatalytic activity of TiO2 P25 | Abstract In this study, we have modified TiO2 P25 photocatalyst by thermal shock method at different temperatures in order to study the effects of thermal shock process on the crystal structure, surface properties and photocatalytic activity. The thermal-shock-modified catalysts were respectively characterized by X ray diffraction (XRD), scanning electronic microscopy (SEM), X ray photoelectron spectroscopy (XPS) and UV–vis diffuse reflectance spectra and compared with thermal-shock-fluorinated TiO2 catalysts. The photocatalytic activity was evaluated via the degradation of methylene blue under UV and visible light irradiation. The results show that the deficiency of oxygen on the surface of catalysts created by thermal shock at 500 °C can enhance the photocatalysis under both UV and visible light. Moreover, when the thermal shock was combined with the fluorination of TiO2, the photocatalytic performance was further improved. However, the thermal shock from 700 °C promoted the growth of particles and the phase transition from anatase to rutile, which resulted in two different effects: inhibit the photocatalysis under UV irradiation but improve it under visible irradiation. | publication |
W2158852027 | The Effect of “Toggling” on the Pullout Strength of Bone Screws in Normal and Osteoporotic Bone Models | This study tests the hypothesis that screw toggling will reduce the pullout strength of bone screws. Pullout strength of cortical (cylindrical) and cancellous (tapered by 4°) bone screws were measured without and after toggling (movement caused by a force perpendicular to the screw axis) by ± 1 mm in polyurethane foam intended to mimic normal (density 0.32 g.cm -3 ) and osteoporotic (density 0.16 g.cm -3 ) bone. Toggling had no significant effect in decreasing the strength of fixation of cortical or cancellous screws inserted in the normal and osteoporotic bone models. Analysis of the screws that had been toggled showed that there was no significant difference (p > 0.05) between the pullout strength of cancellous and cortical screws (when pulled out from the same material). The results provide insights into some mechanical aspects of the pullout strength of bone screws and will aid understanding of the mechanism of screw toggling in vivo. | publication |
W2088718515 | Shadow patching: Minimizing maintenance windows in a virtualized enterprise environment | Software is growing bigger and more complex, which results in bugs and defects being no longer dealt as exceptions, but rather as normal artifacts in a software's lifecycle. In fact, many patches are released by vendors on a preset schedule. This implies that managing patches in a correct and timely manner has become an important factor in smoothly running an IT environment. However, when a patch is applied, the affected software is often required to stop temporarily, which can cause a disruption of service. The down time is commonly called a maintenance window. Although sophisticated live patching techniques have been previously proposed, their applicability in practice is very limited. In this paper, we propose a novel patch management technique based on commonly available virtualization capabilities. It allows system administrators to perform a majority of the patch work outside of the maintenance window, such as downloading patches, installing them, and performing post-installation testing and fixes. By capturing the disk activities and replaying them during the actual maintenance window, we can transform a complex software patching operation to a series of more deterministic file I/O operations, and thus, reducing maintenance window from hours to minutes. | publication |
W1983213839 | Feasibility and Promise of a Remote-Delivered Preconception Motivational Interviewing Intervention to Reduce Risk for Alcohol-Exposed Pregnancy | Alcohol-exposed pregnancy (AEP) is a leading cause of birth defects. Effective face-to-face preconception interventions based on motivational interviewing (MI) exist and should be translated into remote formats for maximum public health impact. This study investigated the feasibility and promise of a one-session, remote-delivered, preconception, MI-based AEP intervention (EARLY Remote) for non-treatment-seeking community women.This was a single-arm, prospective pilot intervention study. All participants received the intervention via telephone and mail. Feasibility of remote-delivery methods, treatment engagement, treatment credibility, MI treatment integrity, and therapeutic alliance were examined. Outcomes were 3- and 6-month drinks per drinking day (DDD), rate of unreliable contraception, and proportion of women at risk for AEP due to continued risk drinking and no or unreliable contraception use.Feasibility of remote delivery was established; participants were engaged by the intervention and rated it as credible. Integrity to MI and therapeutic alliance were good. Both DDD and rate of unreliable contraception decreased significantly over time. Proportions of women who drank at risk levels, used unreliable or no contraception, and/or were at risk for AEP in the past 90 days decreased significantly from baseline to 6 months.Remote delivery was feasible, and the translated remote intervention may reduce AEP risk. Refinement of EARLY Remote may facilitate its placement within a spectrum of effective MI-based preconception AEP interventions as part of a stepped-care approach. EARLY Remote may have an important role within a stepped-care model for dissemination to geographically disperse women at risk for AEP. This could result in substantial public health impact through reduction of AEP on a larger scale. | publication |
W1944759512 | Presence of a high-flow-mediated constriction phenomenon prior to flow-mediated dilation in normal weight, overweight, and obese children and adolescents | When assessing vasomotor endothelial function by reactive hyperemia, the brachial artery, in some individuals, constricts immediately before beginning to dilate following cuff release. We call this response high-flow-mediated constriction (H-FMC). The aim of this study was to describe the rate of the H-FMC during reactive hyperemia in children and adolescents throughout a range of body mass index (BMI) values, and to investigate differences in flow-mediated dilation (FMD), cardiovascular, and anthropometric measures between subjects with and without H-FMC.FMD was assessed in 136 children and adolescents (61 male, 75 female; 13 ± 3 years) by sonographic imaging of the brachial artery. H-FMC was characterized as the lowest point from the baseline brachial artery diameter immediately following reactive cuff release. Independent t tests were used to compare subjects with and without H-FMC.H-FMC was observed in 91 of the 136 participants (66.9%). No significant difference was found between H-FMC and non-H-FMC subjects for age (p = 0.602), gender (p = 0.767), height (p = 0.227), or weight (p = 0.171). BMI percentile was nonsignificantly higher (91.8 ± 4.9th versus 84.6 ± 22.8th percentile, p = 0.057) and FMD was significantly lower (5.43 ± 3.41% versus 8.05 ± 3.97%, p < 0.001) in H-FMC than in non-H-FMC subjects. Adding H-FMC to FMD produced no significant difference between H-FMC and non-H-FMC individuals (8.03 ± 3.27% versus 8.05 ± 3.97%, p = 0.977).Approximately 67% of participants demonstrated an H-FMC during reactive hyperemia. BMI percentile was nonsignificantly higher and FMD was significantly lower in children and adolescents who displayed this phenomenon. | publication |
US 2013/0022134 W | ELECTRICAL CONNECTIVITY WITHIN ARCHITECTURAL GLAZING FRAME SYSTEMS | A system for providing an electrical interface (10) across a sealed boundary (2,3) may include a frame (1,9A) in sealed engagement with at least a portion of a substrate (12,13). The substrate (12,13) may be in communication with an electrochromic device. The system may further include first and second conduits (75,80). The first conduit (75) may be on a first side of the substrate (12,13) and a second conduit (80) may be on a second side of the substrate. The second conduit (80) may be in communication with the first conduit (75) through at least one of the seal (2,3), a space between the seal (2,3) and the frame (1,9A), and a space between the seal (2,3) and the substrate (12,13). | patent |
W1569402938 | Finding Complex Features for Guest Language Fragment Recovery in Resource-Limited Code-Mixed Speech Recognition | The rise of mobile devices and online learning brings into sharp focus the importance of speech recognition not only for the many languages of the world but also for code-mixed speech, especially where English is the second language. The recognition of code-mixed speech, where the speaker mixes languages within a single utterance, is a challenge for both computers and humans, not least because of the limited training data. We conduct research on a Mandarin-English code-mixed lecture corpus, where Mandarin is the host language and English the guest language, and attempt to find complex features for the recovery of English segments that were misrecognized in the initial recognition pass. We propose a multi-level framework wherein both low-level and high-level cues are jointly considered; we use phonotactic, prosodic, and linguistic cues in addition to acoustic-phonetic cues to discriminate at the frame level between English- and Chinese-language segments. We develop a simple and exact method for CRF feature induction, and improved methods for using cascaded features derived from the training corpus. By additionally tuning the data imbalance ratio between English and Chinese, we demonstrate highly significant improvements over previous work in the recovery of English-language segments, and demonstrate performance superior to DNN-based methods. We demonstrate considerable performance improvements not only with the traditional GMM-HMM recognition paradigm but also with a state-of-the-art hybrid CD-HMM-DNN recognition framework. | publication |
223626 | Automated functional screening of iggs for diagnostics of neurodegenerative diseases | The project proposes to organize the exchange of staff of three Academic institutions from Serbia (coordinator), Turkey and Finland, two SMEs from France and Turkey and three TC institutions (two from USA and one from Costa Rica) towards the production of an innovative automated multifunctional device for diagnostics of neurodegenerative diseases.
The objectives addressed will be:
• Development of experimental cellular models and procedures with immunoglobulins (IgGs) from patient sera as diagnostic and prognostic technologies related to neurodegenerative diseases (particularly based on studies of amyotrophic lateral sclerosis - ALS).
• Defining mark-up characteristics of the standardized in vitro approach for personalized diagnostic protocols.
• Design of a small-scale platform based on automated fluorescence microscopy.
These objectives are based on previous studies on ALS of the coordinators group, however the project also proposes to study the applications on other neuroinflammations and neurodegenerative conditions. This addresses a relevant R & I as well as a socioeconomic medical issue. It is the right timing for addresing this research chalange towards application by means of networking that will deal with interesectorial and international exchange of expertise. In addition, three workshops and two training schools will be organized followed by an elaborate dissemination programme. Carrier plans will be designed for the seconded staff in order to maintain the sustainability of the Action. | project/european |
216514 | European research infrastructures in the international landscape | RISCAPE will provide systematic, focused, high quality, comprehensive, consistent and peer-reviewed international landscape analysis report on the position and complementarities of the major European research infrastructures in the international research infrastructure landscape.
To achieve this, RISCAPE will establish a close links with a stakeholder panel representing the main user groups of the report, including representatives from ESFRI, the OECD and Member state funding agencies to ensure usability and the focus of the Report. It will also benefit from close co-operation with other projects and initiatives in the European research infrastructures development to ensure consistency with the existing landscape work. Particularly, RISCAPE builds on the European Research Infrastructures (RIs) in the ESFRI landscape report (2016) and on the landscape analysis done or currently underway in the H2020 cluster projects. RISCAPE leverages the experts on the European RIs with extensive knowledge on the disciplines involved and RI development in Europe and the project benefits from the contacts and tools developed in the cluster- and international RI collaboration projects to maximize the discipline-specific usability of the results.
A key factor in the RISCAPE analysis is that the complementarities will be analyzed in a way which is natural and suitable for the discipline and RI in question. The resulting Report and the used methods will be independently peer reviewed to maximize the usability and objectivity of the information provided for the EU strategic RI development and policy.
The project answers directly to the European Commission strategy on EU international cooperation in research and innovation, particularly on the need to obtain objective information in order to help implement the (EC) strategic approach. | project/european |
637127 | Talent4Bbi: developing talent for bio-based industries of europe | Cutting-edge PhD training in bio-based industries is a critical necessity to tackle the challenges, risks and strategic opportunities of the rapidly evolving European bioeconomy. Talent4BBI will provide a unique opportunity for Early Stage Researchers to develop key skills, competencies and experience required by bio-based industries through a targeted programme for future bioeconomy leaders. Coordinated by BiOrbic Bioeconomy SFI Research Centre at University College Dublin (Ireland) over a 60-month programme duration, 11 ESRs will undertake PhDs of 48 months cohosted by academia and industry. ESRs will be recruited and co-hosted by a consortium of 16 partners across 8 Member States and 1 Associated Country (7 universities and 9 leading bio-based industries) with a wealth of collective experience in training talented mobile researchers. 3 additional partners will contribute their expertise to the training programme. In line with the principles set out in the Charter and Code and with the EU Principles for Innovative Doctoral Training, a unique practice-based pedagogy will enable graduates to thrive in an industrial and academic research setting and enhance ESR career opportunities in line with the MSCA COFUND work programme objectives. Talent4BBI’s selection process will be guided by principles of openness, transparency, merit, impartiality and equality for the ESRs. Talent4BBI will impact the European Research Area through developing a uniquely qualified and career-driven talent pool, driving effective cooperation between industry and academia, and boosting the development of bio-based industries. | project/european |
221791 | European industrial doctorate in innovative polymers for lithium battery technologies | POLYTE-EID European Industrial Doctorate will offer excellent training opportunities to 3 Early Stage Researchers in the area of Polymers for Electrochemical Energy Storage. POLYTE-EID puts together the expertise in batteries for automotive of Toyota Motor Europe (TME) with the academic excellence in polymers of the University of the Basque Country (POLYMAT). The final objective is to train scientists who may face some of the upcoming European energy and transportation challenges. The project proposal is a well-balanced combination of fundamental material&polymer science with applied research in electrochemical energy storage technologies. The project will search the development of new polymeric materials to increase the performance and security of actual and future batteries. | project/european |
3728138 | Computed tomography targets for efficient guidance of catheter ablation in ventricular tachycardia | Patients at risk of ventricular tachycardia (VT), the primary cause of sudden cardiac death, commonly undergo catheter ablation to cauterize the areas within myocardial scars responsible for arrythmias. However, the initial phase of the intervention devoted to identifying the ablation targets currently involves the intra-cardiac insertion of a mapping catheter characterized for being invasive, often inaccurate, and time-consuming. Pre-operative implementation of 3D cardiac imaging approaches to provide detailed structural information on ablation targets could overcome the shortcomings of standard catheter-based mapping. Still, state-of-the-art techniques have not lived up to their potential so far. During his ERC Starting Grant ECSTATIC (2017-2022), Prof. Hubert Cochet at University of Bordeaux developed a novel 3D image-processing technology (MAP-IN-HEART) which would allow cardiologists to locate VT ablation targets and guide ablation procedures in a non-invasive, highly precise and rapid manner using widely available cardiac CT images, without the need for a mapping catheter. In this ERC PoC project, we will investigate the technical feasibility of the innovative MAP-IN-HEART approach by assessing its efficiency and safety in a limited clinical study, and performing a cost-efficiency analysis. Moreover, we will ensure Freedom-To-Operate and explore all the potential paths for commercialization to finally develop a viable business strategy based on the technological aspects, the market needs and trends. Lastly, during this project we will gain technical and commercial proof-of-concept, providing the necessary information for potential commercialisation routes. | project/european |
218623 | Industrialization of software and libraries for crack propagation in material and structures using the thick level set method | The understanding and the reliable prediction of material degradation, crack initiation and propagation is of vital importance in engineering. It allows the evaluation of product lifecycle and the criticality of exceptional loads. Also, it enables maintenance optimization in a wide range of industries (automotive, aircraft, nuclear…). Thanks to the ERC “XLS” grant, a new approach coined TLS (“Thick Level Set”) was developed to simulate crack propagation from sane material to critical rupture. The main advantage of this approach is that it takes into account both crack initiation and crack propagation without mesh size or mesh orientation dependency. This combination is not currently available in the industry.
The TLS software sources (coined TTK for TLS Tool Kit) has been produced mostly during the ERC project. They were recently registered in the software protection agency. The POC goal is to transform the TTK software to industry usable software and to reach a win-win agreement with a well-established service company who will perform paid studies. | project/european |
W2000449117 | Complex formation and background impurity of Oxygen in the PbTe:Eu doped crystals grown from melt by the Bridgman method | Abstract The magnetic field dependence of magnetization M (B) at the temperature 1.72 K in magnetic fields up to 5 T and the temperature dependence of magnetic susceptibility ( M S ) χ (T) in the temperature range 1.7–400 K of six PbTe:Eu samples with the concentration of Eu impurity of the order of 1×10 19 –1×10 20 cm −3 , prepared from the doped crystals grown from the melt by the Bridgman method, have been investigated. It is shown that the dependence of M (B) and χ (T) can be quantitatively explained by the contribution of the single centers of Eu ions, their pairs, and the matrix of the doped crystals using the same set of parameters for each sample. This is true provided we use in our analysis the values of the exchange integrals between Eu ions in EuO normalized with the lattice constant of PbTe, i.e., J 1 /k B =0.056 K for the ferromagnetic interaction of the NN (nearest neighbor) pairs and J 2 /k B =−0.13 K for the antiferromagnetic interaction of the NNN (next nearest neighbor) pairs, as well as different values of the M S of crystal χ matrix . It is revealed that the probability of the formation of complexes based on the magnetic impurity pairs is higher in the incipient section of a doped ingot, and it decreases towards the ingot end where the single centers of Eu ions become the only centers of the impurity. We conclude that the pairs of Eu 2+ ions, which are formed during the growth of the PbTe:Eu ingots from melt by the Bridgman method, are the constituents of the complexes of the magnetic impurities with the background Oxygen impurities in the crystal matrix of the doped lead telluride. It is shown that the formation of the complexes leads to an increase of the M S of crystal matrix χ matrix and can even cause the change of its sign from minus to plus, i.e., it can convert the crystal matrix from the diamagnetic to paramagnetic state. The possible causes of this effect are analyzed. | publication |
Q4923809 | FERVENTO BIORETES | ZIEL DES PROJEKTS IST ES, DAS START-UP „FERVENTO“ EINZURICHTEN, UM „BIORETES“ ZU INDUSTRIALISIEREN UND ZU KOMMERZIALISIEREN, EINE TECHNOLOGIE ZUR SCHNELLEN ENTWICKLUNG VON ONLINE-PLATTFORMEN FÜR DIE BIOINFORMATIK-ANALYSE, DIE GEBRAUCHSFERTIGE WERKZEUGE ZUR INTERPRETATION VON ERGEBNISSEN ENTHÄLT. DIE INNOVATIONSKRAFT VON BIORETES IST SEINE FÄHIGKEIT, DEM MEDIZINISCHEN SEKTOR, DER PHARMAINDUSTRIE UND DER BIOTECHNOLOGIE DEN BEDARF AN INGENIEUR-INFORMATIK-FÄHIGKEITEN FÜR DIE ENTWICKLUNG MARKTREIFER PLATTFORMEN ZU BESEITIGEN: CIò VERSETZT MITTELSTÄNDISCHE BIOTECH-UNTERNEHMEN MIT BIOINFORMATIK-RESSOURCEN OHNE ZUSÄTZLICHE FÄHIGKEITEN IN DIE ENTWICKLUNG MIT KOSTENGÜNSTIGEN, WERTSCHÖPFENDEN UND QUALITATIV HOCHWERTIGEN ANALYSELÖSUNGEN (FEHLERFESTIGKEIT, SKALIERBARKEIT, SOFTWAREWARTUNG). | project/regional |
Q4765516 | BF VON BRIVIO FLAVIO | DAS UNTERNEHMEN HAT SEINEN SITZ IN DER GEMEINDE SAN BARTOLOMEO AL MARE IN DER PROVINZ IMPERIA UND IST SEIT MEHREREN JAHREN AUF DEM SPEZIALISIERTEN BEREICH DER INNENEINRICHTUNG TÄTIG. GEGRÜNDET ALS HANDWERKSWERKSTATT, IST DAS UNTERNEHMEN DER ERBE EINER LANGEN FAMILIENTRADITION DES ERFOLGS, DIE WÄHREND VIER GENERATIONEN VON LOMBARDI TISCHLER KONSOLIDIERT WURDE, AUF DEM GEBIET DER „BRIANZA“, DIE SEIT JEHER DER STANDORT DER EXZELLENZ IM BEREICH DER HOLZBEARBEITUNG UND MASSGESCHNEIDERTE MÖBEL WAR. IN BEZUG AUF DIE PRODUKTION GIBT ES ZWEI LINIEN, NÄMLICH DIE HEIMLINIE FÜR PRIVATPERSONEN UND DIE VERTRAGSLINIE, DIE AUF HOTELEINRICHTUNGEN AUSGERICHTET IST. DIE HAUSLINIE ZEICHNET SICH DURCH DIE HOHE DIFFERENZIERUNG UND EINZIGARTIGKEIT DER PRODUKTE AUS, DIE AN DEN KUNDEN GERICHTET SIND, FÜR DEN PROJEKTE UND REALISIERUNGEN VON MASSGESCHNEIDERTEN MÖBELN VORGESCHLAGEN WERDEN. IN DIESER HINSICHT BAUT „B.F. MOBILI“ SEIT JAHREN EINE FRUCHTBARE ZUSAMMENARBEIT MIT MEHREREN ARCHITEKTEN AUF. WIE FÜR DIE VERTRAGSLINIE IMMER SIE | project/regional |
Q80306 | Alfabeat ALFA – accelerator and investment fund for R & D projects using horizontal information technologies and in the early stages of development | Alfabeat ALFA develops the scope of Alfabeat technology accelerator to invest in R & D projects with high market potential. The capital raised from private investors (PLN 6 million) and public funds (PLN 24 million) will allow for a period of 4 years to identify at least 400 R & D projects matching the Fund’s industry profile, acceleration and legal and technological verification (PoP phase) at least 80 of them, and then invest (PoC phase) in the 20 projects with the highest potential. The objectives will be achieved by: a proprietary process involving: — unique strategy of acquiring projects, – intensive support during the PoP phase (acceleration and verification with the participation of a team member and patent attorney, as well as technological verification identifying technological challenges and preliminary R & D plan), – evaluation of each project by the Board of Experts in the form of a panel, – capital investment after the decision of the Investment Committee, – intensive experience between the new company and the team in the PoC phase (including the supervision of the Polish partners) and the development of the company’s values, but also the construction of the company’s value, – intensive cooperation between the new company and the team in the PoC phase (including supervision and cooperation with partners) — implementation of R & D projects in SMEs and carrying out technological analyses – legal analyses on investment and intellectual property rights – intensive business support of originators under acceleration – making equity investments in seed funds, including BRIdge Alfa – acquiring subsequent rounds of funding and conducting exit transactions c) effective acquisition of R & D projects: — from two target groups – research teams and R & D teams in SMEs | project/regional |
Q2909759 | Antika global and digital | Project to strengthen and qualify Antika’s international presence, through integrated betting on a B2B digital platform, new brands and collections, a plan of prospecting actions and participation in international reference events, as well as a more comprehensive product offering. | project/regional |
GB 9502817 W | STORAGE OF COMPUTER DATA | In a hierarchical storage management system, files are automatically archived when they have not been accessed for a specified period. With large database files, the file cannot be archived, even though only a small number of records has been used. In this invention an auxiliary database is maintained indicating which data blocks have been accessed and on what dates. Non-accessed blocks can then be archived and deleted from the disk file to reduce storage requirements. | patent |
990256 | High power density fc system for aerial passenger vehicle fueled by liquid hydrogen | The main goal of HEAVEN project is to design, develop and integrate a powertrain based on high power fuel cell and cryogenic technology into an existing 2-4 seats aircraft for testing in flight operation. Specifically, the project proposes to design a modular architecture with modular systems that can be scale-up to other sizes of aircrafts and UAV applications. The design methodology is complemented with safety and regulation analysis. Regarding the fuel cell technology, two high power PEM fuel cell systems of 45 kW based on metallic bipolar plates will be adapted for aircraft applications and integrated with optimized balance of plant components to obtain an enhanced 90kW fuel cell system able to propel without support of a battery the aircraft operating modes. The hydrogen storage will be based on cryogenic technology successfully applied in previous space applications in order to achieve a gravimetric index of about 15% for a hydrogen payload between 10 and 25 kg that provides an autonomy range to the demonstrator of 5-8 hours. Moreover, HEAVEN project will leverage existing drivetrain components and an aircraft demonstrator in order to achieve an overall and successful TRL6 at the end of the project. The technology developments will be enriched with economic and business assessments during the execution of the project. Thus, HEAVEN will produce estimations of a total cost of ownership for the entire life cycle of the technology and business plan for the deployment of the technology in different aeronautics applications.
Finally, HEAVEN consortium comprises large companies, SMEs and well-known research center with a strong experience and knowledge in fuel cell technology development for aeronautic applications that is supported with the participation in previous relevant H2020 projects and national projects. | project/european |
W126689139 | The colorectal cancer stem-like cell hypothesis: a pathologist's point of view. | Colorectal cancer is the fourth most common cancer in men and the third most common cancer in women worldwide. The partial failure of classic therapeutic options makes scientists to doubt the efficacy of systemic treatments in targeting the essential cell populations and achieving cure as a final goal. Overgrowing data suggest that cancer is a disease closely linked to stem cells (SCs). It is well known that the first identification of cancer stem-like cells in acute myeloid leukaemia was soon followed by similar results in solid malignancies, including colorectal cancer, and the classic model for colon carcinogenesis supports the development of sudden mutations that will lead to the activation or inactivation of certain oncogenes or tumor suppressors. Thus, this process may go on for years before the first symptoms and the only cells able to withstand for many years, avoid apoptosis and have a high regenerative capacity are the progenitor cells found at the lower part of colon crypts. A more profound study of the mechanisms and molecular signalling pathways that control the basic characteristics of SCs, such as asymmetrical division or self-renewal, may help comprehend the basic mechanisms of cancer genesis and progression. This will result in the development of new therapeutic agents that may target chemoresistant cell populations and improve the therapeutic results. In the current review we point out the importance of cancer stem-like cells in colorectal oncology from a pathologist's point of view, stating the obvious correlation between histology, embryology and surgical pathology. | publication |
FR 2005050741 W | MACHINE FOR TWISTING A FIBROUS TEXTILE MATERIAL | The machine comprises a main fixed frame (1), housing several working positions, each position comprising: on the upper part, a supply unit (A), for textile material and, on the lower part, a spinning and twisting unit (R), in alignment and corresponding with the above. The supply unit (A) has means for a vertical displacement, in a plane essentially parallel to that including said units (A) and (R), corresponding to a height adjustment with relation to the spinning unit (R), in order to permit a concomitant loading and unloading of bodies (2, 3) for said supply unit (A) with a lowering movement (lower level (15)) and/or to provide an adjustment of the textile on adjusting the upper level (14), corresponding to a working position. | patent |
W2277747307 | null | IT Il saggio si interroga sulla possibilità di definire ciò che è bene, e quindi eticamente sostenibile, nell'educazione linguistica.Ovvero, vaglia su quali dimensioni e con quali modalità si debba procedere per una valutazione etica dell'approccio, il metodo e la pratica dell'insegnamento/apprendimento delle lingue.Tale valutazione passerà attraverso la disamina di quel settore di studi che in Italia prende il nome, con sfumature e riferimenti spesso profondamente diversi, di educazione linguistica.Identificare una chiara definizione di questo ambito interdisciplinare di ricerca e del concetto stesso di educazione linguistica, dei suoi elementi cardine e dei suoi specifici oggetti di studio sembra essere un'operazione necessaria e un presupposto indispensabile per una riflessione etica sulle azioni dell'educazione linguistica anche in termini di sostenibilità del sistema glottodidattica. | publication |
Q4753821 | INCREASE COMPETITIVENESS SMES — ECO CENTER SARDEGNA S.R.L. | THE INITIATIVE IS AIMED AT INCREASING THE PRODUCTION CAPACITY OF THE COMPANY’S PLANT THROUGH THE REDEVELOPMENT OF THE EXISTING UNCOVERED AREA FOR THE CREATION OF NEW OPEN-AIR SPACES FOR THE RESERVOIR OF WASTE BY MEANS OF MASONRY WORKS, THE PURCHASE OF A PLANT FOR THE PACKAGING OF THE DRY FRACTION OF MUNICIPAL AND INDUSTRIAL WASTE, OF A TRAILER, OF COMPACTERS AND VARIOUS EQUIPMENT. | project/regional |
interreg_1333 | Female participation in high-tech enterprises | FEMINA partners believe that increased female participation can make high-tech SMEs more competitive. This belief, based on academic studies and practical experience, must become part of mainstream policy.
The gender gap is still visible in high-tech sectors across EU-28: women represented 29% of entrepreneurs in 2014 and 32.5% of employees in high-tech manufacturing and knowledge-intensive services in 2015. This is not a question of social inclusion. It is about economic growth: studies show that the women’s specific skills can help to diversify and consolidate enterprises; that closing the gender gap could generate an EU GDP increase of 13%.
In this context, FEMINA partners cooperate at interregional level to reach their overall aim: to ensure that selected policy instruments are integrated with measures to promote female engagement in their high-tech sectors, with a focus on sectors in their RIS3.
FEMINA considers how to identify, implement, monitor and evaluate policy measures that break down barriers to female high-tech entrepreneurship, to employment and career progression in high-tech SMEs and to the gender dimension of innovation in funding schemes for high-tech start-ups and SMEs.
Policy improvements are foreseen through specific projects funded to address these barriers, through improved policy management (e.g. gender criteria in monitoring) and through strategic focus, whereby partners work to include female participation in high-tech as a fundamental principle of their policies for SME competitiveness.
FEMINA’s main outputs are Action Plans, detailing these desired changes, which partners and selected stakeholders will implement and monitor over a 2-year period. The results of this implementation will benefit SMEs and the territory. An increase in female participation in high-tech entrepreneurship, employment and leadership should establish a culture of gender parity in these sectors, with impact on inclusive growth and regional competitiveness. | project/regional |
W1492916309 | Trends in the First Three Classroom Teachers in City of Irbid towards the Integration of Disabled Students with its Various Dimensions | This study aimed to identify the trends of the first three classroom teachers towards the integration of disabled students with normal students at the first three classrooms in the city of Irbid in the Hashemite Kingdom of Jordan, a questionnaire was distributed to achieve this purpose through measuring the attitudes of teachers towards integrating disabled students with their normal colleagues, where the questionnaire has included three dimensions (psychological , social and academic) and the study sample consisted of 193 teachers who teach the first three classrooms in the city of Irbid. The study concluded by using means, percentages, standard deviations and level of significance that there is a presence of positive attitudes among the teachers towards integration, although there are differences in directions on the dimensions included in the questionnaire, however, these differences were not statistical significant. It was recommended by this study a need for conducting further studies to specify the parents of disabled trends toward the integration. | publication |
2722964 | Empowerment through liquid integration of migrant youth in vulnerable conditions | MIMY is a comparative interdisciplinary study of migrant integration with the aim of empowering young migrants in vulnerable conditions and supporting integration strategies within the EU. The project brings together 11 disciplines and 12 partners to examine the dynamic, open-ended process of integration at the EU, national and local level by examining 18 case studies within 9 countries. MIMY analyzes integration policies and strategies across macro (EU migration policies), meso (regional economic & social systems) and micro (individual practices) levels by establishing a unified theoretical framework at the intersection of liquid integration, resilience and vulnerability. The innovative, multi-method approach (e.g. policy analyses, quantitative data analysis, delphi study and participatory action research) provides in-depth analyses of: 1) the long-term socio-economic effects of successful and failed integration; 2) factors fostering or hindering integration processes of young migrants (considering the heterogeneity and diverse biographical backgrounds); and 3) how diverse social actors and institutions can support the agency of young migrants by further strengthening their resilience and resistance strategies. In contrast to existing approaches, MIMY emphasizes and combines the vertical (multi-level governance structure) and horizontal (sector policies) axes. MIMY will show which integration strategies and policies can successfully support the empowerment of young vulnerable migrants to become active citizens within an inclusive society by working in close cooperation with migrants as peer researchers. It will contribute extensively to integration studies - empirically, methodologically and conceptually - through its place- and gender-sensitive and migrant-centred approach. MIMY offers direct benefits to young migrants and evidence-based policy-recommendations will help to push policy and practice innovation in the field of migrant youth integration in Europe. | project/european |
W1489232115 | Community Detection for Multiplex Social Networks Based on Relational Bayesian Networks | Many techniques have been proposed for community detection in social networks. Most of these techniques are only designed for networks defined by a single relation. However, many real networks are multiplex networks that contain multiple types of relations and different attributes on the nodes. In this paper we propose to use relational Bayesian networks for the specification of probabilistic network models, and develop inference techniques that solve the community detection problem based on these models. The use of relational Bayesian networks as a flexible high-level modeling framework enables us to express different models capturing different aspects of community detection in multiplex networks in a coherent manner, and to use a single inference mechanism for all models. | publication |
895046 | From heat to cold with theac-25®, the thermo acoustic energy converter. | Due to climate change, space and process cooling is becoming the worldwide problem of the near future. With the raising of the average temperature, active air-conditioned cooling is needed throughout the year leading to high costs on electric power consumption (over 30% of the global electric power consumption in Europe, which means €27 billions), on maintenance for compressors as well as on the use of polluting refrigerants and its registration expenses. SOUNDENERGY BV introduces a breakthrough technology that brings a fundamental change in cooling buildings without using electricity or gas. Our company, based in The Netherlands, have a multidisciplinary team, with a well-known world leader researcher of Thermal Acoustics. Currently, we are developing the second generation of THEAC-25®converting heat into cold by using thermo acoustic technology. Our focus is to be able to provide climate control of buildings and industrial processes with zero CO2 emissions, saving 50% in energy consumption, which means between 5,000 - 20,000 kg of CO2 emissions/yearly reductions. The first version of THEAC-25® has been tested with some launching customers such as SENZORA BV. Pilot testing of the second generation of THEAC-25® with potential customers, will be contemplated as part of our commercialisation strategy. CE marking and FDA approval is sought to be able to commercialise on a global scale. SOUNDENERGY will follow a B2B approach to efficiently deliver climate cooling for industrial waste recovery as first target market (€600-700 M). Once we gain traction and market position we will focus on the space cooling for residential and non-residential buildings (€1.27B). We will be able to reach an addressable market size for waste heat recovery only in Europe of over €10M in 2021. Over 2,000 units of THEAC-25® and €40M sales projection has been estimated for the fourth year of commercialization (price €20k/per unit in Y4), with a ROI of 11.16 | project/european |
W1978589893 | Scientific research support in developing sustainable transport in Romania | The aims of this study are to reveal the present level of scientific research in Romania, to identify the obstacles that have caused low support research and development for sustainable transport development in Romania, as well as, to bring into discussion the measures that have been suggested for improving the existing situation, particularly the production and use of biofuels which are considered an important chapter in greening of transport. The study investigated, first the targets, mechanisms and supporting tools for transport scientific research by comparing the situation in Romania with those in some other EU member states, as well as, provided an analysis of the intensity of scientific research in Romania and the requirements for improving the quality and volume of transport using 1990 as the reference year for changing of the national economic system before presenting a set of recommendations for improvement of the transport. | publication |
W2398691949 | Detection of Antibiotic Resistance Genes in Source and Drinking Water Samples from a First Nations Community in Canada | ABSTRACT Access to safe drinking water is now recognized as a human right by the United Nations. In developed countries like Canada, access to clean water is generally not a matter of concern. However, one in every five First Nations reserves is under a drinking water advisory, often due to unacceptable microbiological quality. In this study, we analyzed source and potable water from a First Nations community for the presence of coliform bacteria as well as various antibiotic resistance genes. Samples, including those from drinking water sources, were found to be positive for various antibiotic resistance genes, namely, ampC , tet (A), mecA , β-lactamase genes (SHV-type, TEM-type, CTX-M-type, OXA-1, and CMY-2-type), and carbapenemase genes (KPC, IMP, VIM, NDM, GES, and OXA-48 genes). Not surprisingly, substantial numbers of total coliforms, including Escherichia coli , were recovered from these samples, and this result was also confirmed using Illumina sequencing of the 16S rRNA gene. These findings deserve further attention, as the presence of coliforms and antibiotic resistance genes potentially puts the health of the community members at risk. IMPORTANCE In this study, we highlight the poor microbiological quality of drinking water in a First Nations community in Canada. We examined the coliform load as well as the presence of antibiotic resistance genes in these samples. This study examined the presence of antibiotic-resistant genes in drinking water samples from a First Nations Community in Canada. We believe that our findings are of considerable significance, since the issue of poor water quality in First Nations communities in Canada is often ignored, and our findings will help shed some light on this important issue. | publication |
W2594909647 | Importance and Characterization of Coffee Berry Disease (Colletotrichum kahawae) in Borena and Guji Zones, Southern Ethiopia | Coffee (Coffea arabica L.) is one of the most important cash crops in Ethiopia. Coffee Berry Disease (CBD) caused by Colletotrichum kahawae is the severe disease threatening coffee production in most coffee-growing regions of the country. Field survey was conducted in three major coffee growing districts (Abaya, Bule Hora and Kercha) of Borena and Guji zones during 2012 cropping season to determine the incidence, severity and prevalence of CBD. CBD was prevalent in all the surveyed districts with the overall mean incidence and severity of 49.3 and 14.7%, respectively. Laboratory experiment was conducted at Haramaya University to investigate the characteristics of C. kahawae and other fungal pathogens associated with coffee berries. The proportion frequencies of infected and non-infected coffee berries were ranged from 24-42 and 3-21%, respectively. C. kahawae, F. lateritium and Phoma spp. of fungal pathogens were isolated from infected coffee berries with the proportions of 89.2, 15.2 and 3%, respectively. In general, the study revealed high occurrence, distribution and contamination of CBD in the study areas. Therefore, more extensive empirical assessment of the amount of yield loss due to CBD on most grown varieties in the areas and developing or introducing resistant varieties need to have high priority for developing management options which may enhance sustainable coffee production in the country. | publication |
221332 | Cybergenetics: theory and design tools for biomolecular control systems | We propose to develop a new theory and design tools for the estimation and real-time control of living cells. The control systems designed using these tools will precisely and robustly steer the dynamic behavior of living cells in real time to achieve desired objectives. Cells would be controlled either collectively at the population level, or individually as single cells. The control systems achieving this regulation will be realized either on a digital computer that is interfaced with living cells, or using de novo genetic circuits that are introduced into the cells where they are designed to function as molecular control systems. Our methods will explicitly confront the numerous challenges brought about by the special environment of the cell including nonlinearity, stochasticity, cell-to-cell variability, metabolic burden, etc. The theory and methods developed in this project will thus enable the systematic, rational, and effective feedback control of living cells at the gene level, and will lay the foundation for a new corresponding body of knowledge which we call ``Cybergenetics''. It will also open new research directions in the areas of control theory and estimation.
We also propose to design three cybergenetic control systems, each addressing an important application in biotechnology or therapeutics. In the first, the controller will use light and nutrient supply to precisely regulate gene expression and cell growth in E. coli to achieve high protein and low biomass production rates. The second involves multiple feedback controllers regulating in parallel a large number of single stem cells, and leading to their differentiation to desired fates, e.g. beta cells, with potential for therapeutic applications. Finally, we will engineer into living cells dynamic molecular control systems. Such controllers can be used to monitor physiological variables and secrete biological effectors in a feedback fashion for the treatment of diseases like Type 1 diabetes. | project/european |
W2025287066 | The Partnership of Psychoanalysis and Psychiatry in the Treatment of Psychosis and Borderline States: Its Evolution in North America | The history of psychiatry is about two hundred years old and that of psychoanalysis more than a hundred, with an important anniversary of the latter in 2011. Freud renewed and humanized psychiatry by enriching its static descriptive method with the new dynamic and interpretive discoveries of psychoanalysis. Freud's innovations, while developed in Europe, were integrated into psychiatry briefly by the Swiss School but mainly in the United States. After many years of fruitful collaboration psychiatry and psychoanalysis seemed to part company in the U.S. in the last few decades. However, the tradition of combining psychiatric care with dynamic principles is still considered valid in the treatment of psychoses and severe personality disorders. | publication |
W1566103592 | Phytochemical Investigation of the most important phenolic compounds in Moringa oleifera L. cultivated in Iraq | -This work was aimed to extract and characterize flavonoids and phenolic acids presented in both seeds and leaves of Moringa oleifera L.,that cultivated in Iraq for the first time, by using Soxhlet apparatus and then the extract was analyzed using GC-MS and RP- HPLC with reference standards to identified the phenolic compounds in each part of the plant,Depending on mass fragmentation behavior, base peak and the retention time (TR).This confirmed the presence of phenolic acids such us (Vanillic, Caffeic, Chlorogenic, Cinnamic, Coumaric, Ferulic, Syrinigic) and flavonoids such us Pinoresinol, Apigenin, Rutin, Quercetin, Myricetin and Kaempferol in each part of the plant. | publication |
997147 | Studying the role of quiescent cancer stem cells in gbm development using a novel in vivo cell cycle-based approach | Glioblastoma (GBM) is the most common and aggressive high-grade primary brain tumour in adults. More than 90% of the patients shows recurrence of the disease with a survival of 2 years despite a multitherapeutic approach consisting of a first surgical resection of the brain lesion followed by radio- and chemo-therapy. GBM patients die because of the cancer relapse that evolve becoming not sensitive to the classical therapies. A sub-population of quiescent/slow cycling cancer stem cells (CSCs) has been proposed to be the origin of the cancer relapse. The features and role of that specific population of CSCs within GBM is still not well characterised. The aim of the proposed project is to first clarify the cell cycle state of CSCs within GBM induced in mouse models in addition to their contribution and role in cancer development. To achieve this goal, I will use a cell cycle-based approach together GBM mouse models to: characterise the cell cycle state of CSCs within tumour (Aim 1); analyse the contribution of quiescent and proliferating CSCs during cancer development and their molecular features using a novel cell cycle-based lineage tracing approach (Aim 2); analyse the effect of selective ablation of each CSCs sub-subpopulation in cancer growth a novel cell cycle-based cellular ablation (Aim 3). Using a cell cycle point of view, the obtained results will be fundamental for the definition and the role of the different CSCs co-existing within glioma. In particular, the findings will open new avenue in the study of the role of quiescent or proliferating cells within GBM and give the possibility to others in the field for testing for example which cells contribute to cancer relapse after the initial tumour treatment (mass debulking and following radio- and chemo-therapy) or even design new drugs targeting specific CSC types. | project/european |
W2289074360 | Financing renewable energy projects through regional operational programmes | Regional operational programmes provide support granted from EU funds for different projects implemented in individual voivodeships in Poland. The aim of the programmes is to improve the competitiveness of regions and to promote the sustainable development. The priorities of the regional programmes include inter alia transport, environmental protection and sustainable energy production. The aim of the article is to analyze the support provided from chosen regional operational programmes for projects in renewable energy in Poland. The projects aimed at increasing the amount of electricity or heat produced from renewable resources and included for example modernisation of hydroelectric power plants or the installation of solar thermal collectors. The article discusses the effects of the support and difficulties in implementation. The analysis included regional program documents and data on the support provided. | publication |
W2011194715 | Universal corrections to scaling for block entanglement in spin-1/2<i>XX</i>chains | We consider the R\'enyi entropies $S_n(\ell)$ in the one dimensional spin-1/2 Heisenberg XX chain in a magnetic field. The case n=1 corresponds to the von Neumann ``entanglement'' entropy. Using a combination of methods based on the generalized Fisher-Hartwig conjecture and a recurrence relation connected to the Painlev\'e VI differential equation we obtain the asymptotic behaviour, accurate to order ${\cal O}(\ell^{-3})$, of the R\'enyi entropies $S_n(\ell)$ for large block lengths $\ell$. For n=1,2,3,10 this constitutes the 3,6,10,48 leading terms respectively. The o(1) contributions are found to exhibit a rich structure of oscillatory behaviour, which we analyze in some detail both for finite $n$ and in the limit $n\to\infty$. | publication |
2717733 | Paleomagnetism and rock-magnetism by micro-magnetic tomography | Our knowledge on the past behavior of the Earth’s magnetic field critically depends on our ability to obtain and interpret magnetic signals from geological materials such as lavas. These materials contain mixtures of different magnetic minerals, some of which are good recorders of the Earth’s magnetic field, others are not. Even the presence of a small amount of minerals with adverse magnetic properties obscures the signal of good recorders, resulting in >80% of measurements of the past Earth’s magnetic field strength being flawed. Understanding the Earth’s magnetic field is pivotal for predicting the future of its shielding capacity against the Sun’s electromagnetically charged particles, which globally weakened by >20% over the last millennium.
With MIMATOM, I aim to establish an entirely new way to obtain paleomagnetic and rock-magnetic information from geological materials. I will go beyond measuring magnetizations of bulk samples by determining the magnetic moments of individual minerals embedded in these samples in a non-destructive way. Starting from my recent proof-of-concept of Micro-Magnetic Tomography (MMT), I will develop a radically new technique to assess magnetizations of individual minerals inside geological materials. This will enable understanding which minerals are reliable recorders of the Earth’s magnetic field by characterizing their magnetic behavior as function of their grain size, shape, and chemistry. Then I will use MMT to obtain paleomagnetic information from selections of minerals that I identified as good recorders and unlock information on the past state of the Earth’s magnetic field from even the most challenging and magnetically complex geological materials, such as lavas.
My revolutionary new technique will open archives of the past behavior of the Earth’s magnetic field that currently are inaccessible. Moreover, it will pave the way for radically new venues in paleomagnetic and rock-magnetic research, at mineral level. | project/european |
W1966708127 | Spectroscopic and Molecular Modeling Based Approaches to Study on the Binding Behavior of DNA with a Copper (II) Complex | Blocking the division of tumor cells by small-molecules is currently of great interest for the design of new antitumor drugs. The interaction of a new metal complex with DNA was investigated through several techniques. Absorption spectroscopy and gel electrophoresis studies on the interaction of the Cu-complex of (2a-4mpyH)2 [Cu(pyzdc)2 (H2O)2].6 H2O with DNA have shown that this complex can bind to CT-DNA with binding constant 3.99 × 10(5) M(-1). The cyclic voltammetry (CV) responses of the metal complex in the presence of CT-DNA have shown that the metal complex can bind to CT-DNA through partial intercalation mode and this is consistent with molecular docking analysis, quenching process and thermal denaturation experiments. The cytotoxicity of this complex has been evaluated by MTT assay. The results of cell viability assay on DU145 cell line revealed that the metal complex had cytotoxic effects. | publication |
984662 | Innovative technology for removal of toxic metals form highly contaminated soil & sediments | In Europe, more than 340 000 sites are likely to be highly contaminated and in need of remediation measure. About 20% of farmland soil in China require urgent remediation action. Urban soils are contaminated by Pb-based paint and emissions from the combustion of leaded gasoline in all major cities in US. Lead was identified by WHO as 1 of 10 chemicals of major public health concern. Urban soil is a lingering source of lead poisoning in children. Most countries have made the clean-up and restoration of the contaminated land a priority thus creating the opportunity for soil preserving remediation options. The remediation of contaminated soil is essential for the protection of environmental resources and human health. There are no effective and sustainable (soil preserving) remediation technologies for soils contaminated primarily with Pb. Excavation with landfilling is unfortunately still one of the most used solutions (used in 82-84% of cases. ReSoil is the single available remediation option which efficiently removes Pb and other toxic metals from contaminated soils and preserves soil as a natural resource. ReSoil is EDTA-based soil-washing technology with innovative technology for recycling of EDTA and process waters in closed-loop and thus ensuring generation of no liquid wastes. ReSoil is a breakthrough, globally important green environmental innovation in the verge of commercialization. ReSoil demonstration plant (6 t/day) and demonstration garden are available. Low operation and remediation cost, no environmental emission and preserving soil as a natural resource for safe food production make ReSoil technology disruptive innovation in the growing soil remediation market (8% annual growth rate). Increasing public concern and awareness requires new effective and cost-efficient gentle remediation options. ENVIT is an engineering company with an aim to offer the world the efficient solution for removal of lead and other pollutants from soil. | project/european |
Q4754653 | BEIHILFE FÜR DEN BEGINN EINER NEUEN HOTELUNTERKUNFT (AFFITTACAMERE) – PSL00263 | DIE INTERVENTION BEINHALTETE DEN BAU EINES GÄSTEHAUSES, DAS SICH IM HISTORISCHEN ZENTRUM VON DORGALI BEFINDET UND NACH KRITERIEN DES RESPEKTS UND DER VERBESSERUNG DER LOKALEN SARDISCHEN TRADITIONEN UND DER UMWELT GEBAUT WURDE. DIE UNTERKUNFT WURDE NACH DEN TYPISCHEN SARDISCHEN GASTLICHKEITSKRITERIEN GEBAUT, SOWOHL AUS STRUKTURELLER UND ARCHITEKTONISCHER SICHT ALS AUCH AUS DER EINRICHTUNGSPERSPEKTIVE. SIE WURDEN RESPEKTIERT, IN DER TAT DIE ARCHITEKTUR DER ALTEN HÄUSER VON DORGALE UND DIE ZIMMER SIND MIT ARTEFAKTEN DER LOKALEN KUNSTHANDWERK EINGERICHTET. UNTER DEN MARKTZIELEN SIND JENE NORDEUROPAS UND INSBESONDERE DIEJENIGEN, DIE NEBEN DEM MEER UND DER SCHÖNHEIT DER LANDSCHAFT VON NATURALISTISCHEN UND KULTURELLEN EXKURSIONEN ANGEZOGEN WERDEN, UM AUCH IN EINEM WOHNKONTEXT ZU LEBEN, DER MIT DEN WERTEN DER TRADITION UND DES RESPEKTS FÜR DIE UMWELT VERBUNDEN IST. | project/regional |
3726643 | Safely optimized runway throughput | The expected rapid growth in air traffic will lead to an increasing number of capacity constrained airports. Therefore airports have to improve significantly the runway and airport throughput while maintaining or increasing runway safety levels. In SESAR 2020 WAVE-1 this was mainly addressed by PJ02 with the four solutions:
PJ.02-01: Wake turbulence separation optimisation
PJ.02-02: Enhanced arrival procedures
PJ.02-03: Minimum Pair Separations based on required surveillance performance
PJ.02-08: Traffic optimisation on single and multiple runway airports
This VLD covers four solutions:
The use of aircraft type-specific pairwise separation will be used at Heathrow Airport, focusing on the runway occupancy time part of the overall TBS concept. At Vienna, the use of a wake decay enhancing device is intended to be demonstrated. There will be a demonstration at Zurich Airport of a concept known as ROCAT, which enables a reduction in the surveillance separation minimum for in-trail pairs on final approach, including a revised runway occupancy time aircraft classification. The benefits of an integrated AMAN-DMAN runway sequencer will be demonstrated at Stockholm Arlanda in shadow mode.
Together these demonstrations will collect evidence of the concept(s) within the overall time-based separation concept. As such the proposed large scale demo VLD3-W2 SORT closes the gap between the actual concept development and the deployment (or pre-industrialization) phases by demonstrating the operational and technical readiness. And by doing so de-risking the later deployment phases of these four solutions, either in real life trials and/or shadow modes trials at major European airports, this will ensure trust in the SESAR results. | project/european |
Q3272715 | USS | Zweck und Ziel des FEI-Projekts ist die Entwicklung eines neuen Systems zur Selbstabschottung der Abdeckungen verschiedener Geräte und Geräte, die zur Verwendung in Einzelhandelsgeräten für den Vertrieb von Lebensmitteln bestimmt sind. | project/regional |
W1997092027 | FEM modeling of dynamical recrystallization during multi-pass hot rolling of AM50 alloy and experimental verification | The microstructure simulation during the multi-pass hot rolling of AM50 alloy was studied by DEFORM-3D. The excellent agreement with the experiment observations shows that the present modeling and user routine are feasible for the reproduce of the hot rolling process. The multi-pass hot rolling contributes to the achievement of a uniformly recrystallized microstructure with fine grains in the rolled sheet. The sheet temperature before the finish rolling strongly affects the final grain size, but hardly affects the grain size distribution. This modeling and the user routine also have a potential to be applied in the researches of the other multi-pass hot deformation process. | publication |
W2101979161 | A comparison of active management and expectant management of the third stage of labour: a Swedish randomised controlled trial | to compare blood loss in women actively and expectantly managed in the third stage of labour.randomised controlled trial (RCT).two delivery units at a Swedish university hospital.healthy women with normal pregnancies, at gestational age 34-43 weeks, with singleton cephalic presentation and expected vaginal delivery.the women were randomly allocated to either active (n = 903) or expectant (n = 899) management of the third stage of labour.the primary outcome was blood loss > 1000 ml, and secondary outcomes were mean blood loss, duration of third stage, retained placenta, haemoglobin level and blood transfusion.blood loss > 1000 ml occurred in 10% of the actively managed group and 16.8% of the expectantly managed group (P < 0.001). Mean blood loss was 535 ml in the actively managed group and 680 ml in the expectantly managed group (P < 0.001). A prolonged duration of the third stage was associated with increased blood loss. Increased placenta weight was associated with increased blood loss. The haemoglobin level was 118 g/dl in actively managed women and 115/dl in expectantly managed women (P < 0.001) the day after childbirth. The occurrence of retained placenta and the number of blood transfusions did not differ between the groups.active management of the third stage of labour was associated with less blood loss compared with expectant management. It is reasonable to advocate this regime, especially in primiparous women. | publication |
W2903654494 | The Influence of Dust and Black Carbon on Clouds, in Africa | The aerosol can change the clouds properties; the clouds, however, affect the normal behavior of aerosol optical depth. Considerable effects arise while the interaction of aerosol and clouds unavoidably encounters the presence of greenhouse gases (GHGs) in atmosphere. This research discusses the influence of two selected aerosol types, on the clouds in Africa, over the selected sub-time series in the years 1980-2018. Sahara desert’s dust is mainly constituted by hematite minerals; which, in return, is mainly composed by the iron oxides, a powerful solar and infra-red radiation absorbing matter and thus a strong and direct radiative forcing agent. For that reason, together with the fact that it is windblown over the biggest region that surrounds the desert, dust is one of the strongly considered aerosol in this research. Besides, black carbon (BC), mostly from the anthropogenic biomass burning process in the mid latitude’s African savanna, is the second aerosol type selected for this research: it is one of the abundantly available aerosol types and it is one of the strongest atmospheric radiant energy absorbers. For sake of valid and trustworthy results, the data is collected from multiple satellite remote sensing tools and instruments, all targeting the aerosol-cloud interaction and effects. In this research, different measurements were carried out; those are the spatiotemporal averaged cloud cover, the aerosol (dust and BC) extinction optical thickness (AOT), the anomaly of aerosol optical depth (AAOD) as well as different scatter plots’ correlation analysis. For findings: the direct influence of hydrophilic BC on clouds formation in central African sub-region is experimentally demonstrated; the dust aerosol highly influences the North African sub-region’s cloud formation. | publication |
3744213 | Role of tissue mechanics in embryonic self-organization and cell fate plasticity | How molecular and mechanical cues interplay to coordinate the morphogenesis and patterning of embryonic structures is an open question in developmental biology. The early avian embryo is an ideal model for the study of such interplay as it exhibits highly regulative development, is greatly amenable to live imaging approaches and can be readily mechanically challenged. Whereas avian embryos have long been known to remarkably adapt and readjust cell fate upon surgical perturbations, such regulative potential has been investigated solely from a molecular standpoint, leaving the role for mechanical forces unexplored. This proposal builds on our recent results and methods characterizing the mechanical control of gastrulation to investigate the role of mechanical forces in embryonic regulation and in cell fate plasticity. Specifically, we propose 1) to develop innovative tools allowing to perturb the mechanical state of early embryos in order characterize the role of forces during development; 2) to test whether a mechanical self-organizing system underlies the remarkable regulative potential avian embryos; 3) to investigate the role of mechanical forces in mesoderm, embryonic and extra-embryonic regional fate allocation. To this end, we will use an interdisciplinary approach combining novel transgenic quail lines, live imaging, and pharmacological/molecular/optogenetic/mechanical perturbations along with theoretical frameworks and modeling approaches. These studies will decipher the interplay between cellular, molecular and mechanical cues that ensures the robust, yet plastic allocation of cell fate in amniote embryos (i.e. reptiles, birds and mammals, including humans). | project/european |
interreg_589 | Creating a cross-border club for the promotion of products of artisanal fisheries | The project aims at promoting the socio-economic development and regional integration of the territories through the development, qualification and integration of the supply chain of small-scale fisheries with the tourism sector in Sicily and in Tunisia, through the creation of a club of certified fishery products - The Blue Club.
Artisanal fishermen would have the means to provide restaurants with a product which is identified, traceable and quality-controlled. In return, the catering facilities are supported in a sustainability course of the services offered by directing their offer on the development of the specificities of their territories and on the quality of services offered. | project/regional |
W2294078475 | Neuroimaging in Alzheimer's disease: preclinical challenges toward clinical efficacy | The scope of this review focuses on recent applications in preclinical and clinical magnetic resonance imaging (MRI) toward accomplishing the goals of early detection and responses to therapy in animal models of Alzheimer's disease (AD). Driven by the outstanding efforts of the Alzheimer's Disease Neuroimaging Initiative (ADNI), a truly invaluable resource, the initial use of MRI in AD imaging has been to assess changes in brain anatomy, specifically assessing brain shrinkage and regional changes in white matter tractography using diffusion tensor imaging. However, advances in MRI have led to multiple efforts toward imaging amyloid beta plaques first without and then with the use of MRI contrast agents. These technological advancements have met with limited success and are not yet appropriate for the clinic. Recent developments in molecular imaging inclusive of high-power liposomal-based MRI contrast agents as well as fluorine 19 ((19)F) MRI and manganese enhanced MRI have begun to propel promising advances toward not only plaque imaging but also using MRI to detect perturbations in subcellular processes occurring within the neuron. This review concludes with a discussion about the necessity for the development of novel preclinical models of AD that better recapitulate human AD for the imaging to truly be meaningful and for substantive progress to be made toward understanding and effectively treating AD. Furthermore, the continued support of outstanding programs such as ADNI as well as the development of novel molecular imaging agents and MRI fast scanning sequences will also be requisite to effectively translate preclinical findings to the clinic. | publication |
Q78040 | Innovative voltage converter 3 kV/3x400V-380V/24V for the T&T sector (energy-saving power system for locomotives, wagons and other rail vehicles). | Reference number of the aid programme: SA.41471(2015/X) Purpose of public aid: Article 25 of EC Regulation No 651/2014 of 17 June 2014 declaring certain types of aid compatible with the internal market in the application of Articles 107 and 108 of the Treaty (OJ L. I'm sorry. EU L 187/1 of 26.06.2014). The project focuses on the development of an innovative 3 kV voltage converter for the rail transport sector, which is an energy-efficient vehicle power supply system (EZT, locomotives, wagons and other medium-voltage modes of transport). It will be a new product portfolio for the company, comprehensively complementing the offer for the growing Traction ∓Transport market. The industry expects solutions aimed at increasing energy efficiency and enabling them to do so. “Language” of vehicles. APS Energy, meeting the expectations of the market and taking into account the long-term “MASTER PLAN FOR TRANSPORT TRANSPORT IN POLAND till 2030” for the Ministry of Infrastructure, will develop a voltage inverter: — highly efficient (95 %-97 %) to 14 percentage points more than competition, with low harmonic content, high overload (approx. 60 %) – reliable in harsh weather conditions (+ 40/-30 °C); placed on the roof, in an environment of strong vibrations, aerodynamic forces, impurities. — the lightest on the market thanks to the project’s resonance technology and multi-level technology adapted for use on roofs and chassis of rail vehicles, the small weight of roof inverters is expected by rolling stock manufacturers to continuously increase the energy efficiency and aerodynamics of their products – modular – distinguished by the ease of servicing in the medium voltage of 3 kV. | project/regional |
W2811120927 | Adiabatic Heating of Electrons in the Magnetospheric Current Sheet | Electron dynamics and acceleration in an electromagnetic field configuration modeling the current sheet configuration of the Earth’s magnetotail region is investigated. A focus is made on the role of the dawn−dusk magnetic field component By in the convection electron heating by an electric field Ey. For numerical integration of a large number of test particle trajectories over long time intervals, the equations of motion written in the guiding center approximation are used. It is shown that the presence of a By ≠ 0 magnetic field significantly changes the electron heating and allows electrons with small pitch angles to gain energy much more efficiently than the equatorial electrons. As a result, the convection heating in the current sheet with By ≠ 0 leads to the formation of an accelerated anisotropic population of particles with energies higher than a few hundred electronvolts. The obtained results and spacecraft observations in the Earth’s magnetotail are compared, and possible limitations in the proposed model approaches are discussed. | publication |
W2370812978 | Research on the System of Construction Engineering Sociology | A lot of social problems are triggered and discussed with the prosperity in the construction engineering in recent years,which can not be explained only by the engineering subjects about construction.As the comprehensive and deepening inspective,sociology must be introduced.Applying the sociology theories on the construction engineering,the article puts forward the pioneering concept field of construction engineering society and explores the meanings and properties of construction engineering society.Based on all of this,the article frames the research objects and methods of Sociology of Construction Engineering.The realistic and scientific significance of the development of sociology of construction engineering as a subject is also demonstrated. | publication |
173310 | Establishing of een-services for supporting the key account management process in the sme-instrument and enhancing the innovation management capacities of smes – kamino | KAMINO is a package of assessments, proceedings and consultations to give support for SMEs to establish and strengthen innovation management capacities in the small and medium-sized enterprises economy. The project is derived from the Horizon 2020 programme initiated by the European Commission to establish new services of the Enterprise Europe Network consortia in the field of innovation.
The objective of the project is first to assess the innovation capacities, innovation processes, innovation strategies and internal organizations of SMEs as well as their relation with innovation partners. Secondly, the project aims to understand the SMEs' capacity in these processes, eventually existing or implemented tools in their innovation management. Thirdly, it is the question of internationalisation. As results of these steps the consultants of the project team are able to identify gaps and bottlenecks and can – jointly with the SME – discuss and define measures and work plans to overcome them.
In the following the project aims to support the advised SMEs in their efforts, encourage them and give advice to achieve jointly defined targets.
The consortium of four partners, the Industrie- und Handelskammer zu Rostock, the ATI Kueste GmbH, the Steinbeis Forschungszentrum Nordost and the Technologiepark Warnemünde will work on the mentioned activities. The IHK zu Rostock acts only as a coordinator for this specific action.
For the realisation of the assessment process the partners will deploy assessment tools with the SMEs in question. The acquisition of the potential SMEs takes place by the selection of suitable enterprises from various sources of the partners and by a selection with a list of criteria for the innovation management enhancement process (EIMC). For the key account management process (KAM) the potentials will be nominated by the Commission through a special evaluation process. The plan is to perform assessments on 20 KAMINO service packages, KAM and EIMC, to SMEs. | project/european |
W2009244621 | Glaciochemical investigations of the ice deposit of Vukušić Ice Cave, Velebit Mountain, Croatia | Abstract. The 3H activity and the concentration of 23 metals and metalloids have been analysed in cave ice samples from the perennial cave ice deposit of Vukušić Ice Cave, Velebit Mt., Croatia. The results of tritium measurements exclude a secular age for the upper 2.4 m of ice deposition, and provide clear arguments that the sampled ice sequence consists of frozen post-1950 precipitation. Measured concentrations of most of the analysed elements have largely surmounted reported concentrations of similar elements from local precipitation or Alpine snow/firn/ice records, whereas three metals (Cr, Cu, Pb) show concentrations comparable to them. Principal component analysis was used to select three groups of elements. The Ca-Mg-governed group (PC1) encompasses the bedrock-related components; their fluctuation might thus reflect the past intensity of dissolution in the epikarst. PC2, with the most characteristic elements being Na, Cr and Pb, probably preserved an atmospheric depositional signal. PC3 is governed by Al and Fe. This probably carries the distal, non-karstic crustal signal and hence might be related to atmospheric circulation (i.e., wind direction and speed). | publication |
W2506298170 | Examination of myocardial electrophysiology using novel panoramic optical mapping techniques | Optical mapping of voltage signals has revolutionised the field and study of cardiac electrophysiology by providing the means to visualise changes in electrical activity at a high temporal and spatial resolution from the cellular to the whole heart level under both normal and disease conditions. The aim of this thesis was to develop a novel method of panoramic optical mapping using a single camera and to study myocardial electrophysiology in isolated Langendorff-perfused rabbit hearts. First, proper procedures for selection, filtering and analysis of the optical data recorded from the panoramic optical mapping system were established. This work was followed by extensive characterisation of the electrical activity across the epicardial surface of the preparation investigating time and heart dependent effects.
In an initial study, features of epicardial electrophysiology were examined as the temperature of the heart was reduced below physiological values. This manoeuvre was chosen to mimic the temperatures experienced during various levels of hypothermia in vivo, a condition known to promote arrhythmias. The facility for panoramic optical mapping allowed the extent of changes in conduction timing and pattern of ventricular activation and repolarisation to be assessed.
In the main experimental section, changes in epicardial electrical activity were assessed under various pacing conditions in both normal hearts and in a rabbit model of chronic MI. In these experiments, there was significant changes in the pattern of electrical activation corresponding with the changes in pacing regime. These experiments demonstrated a negative correlation between activation time and APD, which was not maintained during ventricular pacing. This suggests that activation pattern is not the sole determinant of action potential duration in intact hearts. Lastly, a realistic 3D computational model of the rabbit left ventricle was developed to simulate the passive and active mechanical properties of the heart. The aim of this model was to infer further information from the experimental optical mapping studies. In future, it would be feasible to gain insight into the electrical and mechanical performance of the heart by simulating experimental pacing conditions in the model. | publication |
Q2730966 | Creación de tiendas WEB | Hasta ahora, Zoma no ha utilizado Internet como medio de venta de sus productos. Las tendencias de la sociedad están orientando a un número cada vez mayor de jóvenes hacia el uso de Internet a la hora de elegir comprar productos. El objetivo del proyecto es desarrollar una tienda web que incluya los detalles del programa de producción de la carpintería de Zoma, con el fin de aumentar la competitividad en los mercados nacionales y extranjeros. La tienda web ayudará a aumentar los productos a medida de la carpintería interior y exterior y permitirá a los clientes comparar productos con sus competidores. Los grupos destinatarios son las personas físicas y jurídicas que permitirán la configuración en línea de los productos de carpintería, así como sus pedidos y pagos directos. | project/regional |
US 2010/0061498 W | WATER-DISPERSIBLE SILICONE RESINS | A process for preparing an aqueous dispersion of a silicone resin is disclosed by reacting a mixture containing an alkylalkoxysilane and a cationic alkoxysilane to form a self dispersing silicone resin and subsequently combining the silicone resin with water to form the dispersion. The resulting dispersions are useful for forming coatings on various substrates that are essentially free of co-surfactants or volatile organic solvents. | patent |
W2106510916 | Understanding and improving app installation security mechanisms through empirical analysis of android | We provide a detailed analysis of two largely unexplored aspects of the security decisions made by the Android operating system during the app installation process: update integrity and UID assignment. To inform our analysis, we collect a dataset of Android application metadata and extract features from these binaries to gain a better understanding of how developers interact with the security mechanisms invoked during installation. Using the dataset, we find empirical evidence that Android's current signing architecture does not encourage best security practices. We also find that limitations of Android's UID sharing method force developers to write custom code rather than rely on OS-level mechanisms for secure data transfer between apps. As a result of our analysis, we recommend incrementally deployable improvements, including a novel UID sharing mechanism with applicability to signature-level permissions. We additionally discuss mitigation options for a security bug in Google's Play store, which allows apps to transparently obtain more privileges than those requested in the manifest. | publication |
218526 | Variable compression ratio system for the reduction of fuel consumption and co2 emissions in motor vehicles | Increasingly stringent emission and fuel economy standards have been pushing old combustion engines into an accelerated evolution phase. In this context, OEMs in the industry have shifted their R&D efforts towards more thermally efficient, less polluting and down-sized engines, thus viewing the production of low emission and fuel consumption vehicles. The concept of VCR engines (i.e. the compression ratio (CR) of the internal combustion engine can be modified under dynamic driving conditions and performance needs) has been considered as an essential future technology to meet these targets. However limitations associated with their effect in engine’s architecture, their impact on the reduction of CO2 emissions and additional productions costs have hindered their widespread commercial application.
Our ground-breaking VCR system will be the first able to address the burning needs of the industry. Gomecsys VCR system is a highly innovative system differentiated from alternatives due to its engineering simplicity able to significantly enhance the performance of conventional combustion engines achieving a staggering 5-10% reduction on fuel consumption and CO2 emissions. Our core aim is to commercialize the 6th generation of our VCR system in 2020 and its commercial viability will be based on our ability to define business opportunities in target markets and attract key partners and customer OEMs for our project. Moreover, we are convinced that our project will provide “resource efficient transport that respects the environment” which is considered a critical aspect to meet “Smart, Green and Integrated Transport” societal challenge addressed by Horizon 2020 programme.
Finally, through the completion of Gomecsys VCR system project we expect to reach €15 million revenues five years after its commercialization. Phase 2 will require a €2 million investment, which will present a Cumulative Return of Investment of 4.99 in 2024. | project/european |
W4313247507 | O primeiro povoamento do Homo sapiens na Itália | O Uluzziano é um tecno-complexo que data entre aproximadamente 45.000 a 40.000 anos AP, e está associado ao período em que os Neandertais desaparecem e tem-se o início do sinal arqueológico do Homo sapiens na Europa. Este tecno-complexo foi inicialmente descrito tipologicamente, com base nos materiais encontrados em Grotta del Cavallo (Salento, Puglia, sudeste da Itália). Sua caracterização inicial indicou que apresentava características que geralmente são consideradas típicas do chamado "comportamento moderno", incluindo a presença de substâncias corantes, ferramentas ósseas e ornamentos. Além disso, o Uluzziano representa uma ruptura material brusca em comparação ao tecno-complexo Musteriense, anterior e parcialmente contemporâneo, tanto do ponto de vista tecnológico como de estratégia de caça e subsistência. O objetivo deste trabalho é apresentar a história da definição deste tecno-complexo, suas características em relação à indústria lítica, indústria óssea, ornamentos, e métodos de subsistência. Serão apresentadas as hipóteses sobre sua origem e seu fim, e sua relevância para o debate sobre a transição do Paleolítico Superior Médio na Europa. | publication |
W2473766790 | Antioxidant Activities and Cytotoxicity of Zingiber zerumbet (L.) Smith Rhizome | Zingiber zerumbet (L.) Smith, popularly known as shampoo ginger, is one of the most commonly used ingredients in Indo-Malaysian traditional medicines. The antioxidant and cytotoxic activities of the ethanolic extract of Z. zerumbet rhizome (ZZ) was investigated. 2,2-di(4-tert-octylphenyl)-1picryl-hydrazyl (DPPH) and hydroxyl radical scavenging assays showed significant radical scavenging activities of ZZ. The extract was rich in polyphenol and flavonoids. Cytotoxicity was assessed in vitro by trypan blue exclusion test. Human peripheral blood lymphocyte cells were incubated in different concentrations of ZZ (0, 15, 30, 60, 120, 300 and 600 µg/ml) for 3 h at 37 °C. The rhizome extract was found to be cytotoxic at concentrations higher for human consumption. In addition, HPLC analysis revealed ZZ as a rich source of kaempferol. Based on the results of the present investigation the rhizome may be used safely as a therapeutic antioxidant. | publication |
W2014676207 | Enhancing the antitumor cell proliferation and Cu2+-chelating effects of black soybeans through fermentation with Aspergillus awamori | In the present study, black soybeans were fermented with Aspergillus awamori at 30°C for 3 days. The effect of fermentation on the antiproliferative effect against human colon cancer cells, Caco-2 and HT-29 as well as Cu 2+ -chelating effect of black soybeans was investigated. It was found that the water, 80% methanol or 80% ethanol extract of fermented black soybeans showed a significantly higher ( P < 0.05) antiproliferative and Cu 2+ -chelating effect than did the respective extract of non-fermented black soybeans. Generally, the methanol extract and the ethanol extract of fermented black soybeans exerted higher antiproliferative effect on both Caco-2 and HT-29 cells. While water extract of fermented black soybeans showed the highest Cu 2+ -chelating effect among the various extracts examined. Taking into account of extraction yields further revealed that bioactive principles that exhibit Cu 2+ -chelating effect could be extracted to the largest extent with water as the extraction solvent. With same amount of sample, water extract obtained from fermented black soybeans possesses the highest Cu 2+ -chelating abilities. | publication |
W1732411252 | Using the Wii Remote for Mobile Device Application Testing | There has been a dramatic shift in the interaction methods of mobile devices over the past decade. From devices simply being able to make phone calls to being able to handle complex tasks traditionally performed on personal computers (PCs); this change has led to new interaction issues that need to be understood during the application development process, particularly as these devices now commonly incorporate a touch-screen as their primary source of input. Currently, the methods of conducting software user experience testing of these devices employs techniques that were developed for PCs, however mobile devices are used within different contexts of use. This research initially reviews the current methods for user experience testing of applications running on mobile devices and then presents, through a proof-of-concept approach, an innovative method for conducting user experience testing employing actual devices. | publication |
895181 | Digitalhealtheurope: support to a digital health and care innovation initiative in the context of digital single market strategy | DigitalHealthEurope will provide comprehensive, centralised support to the digital transformation of health and care (DTHC) priorities of the Digital Single Market. The partners bring a broad range of collective knowledge and expertise, originating from the longstanding leadership and engagement in the whole spectrum of activities, from interoperability and standards to health service innovation and from the technical to the policy level. The project will support large-scale deployment of digital solutions for person-centred integrated care by identifying, analysing, and facilitating the replication of highly impactful best practices, utilising the consortium’s exceptional expertise on knowledge management and impact assessment (EIP on AHA repository of innovative practices, MAFEIP), twinning schemes, and mobilisation of stakeholders. A marketplace will enable organisations to find suitable partnerships. At least 46 twinnings ranging from adaptation of impactful best practices to full adoption will be carried out. A funding advice service and capacity building framework will be provided to further stimulate deployment and scale up. Building on the unique composition of the consortium, the project will establish and manage 3 collaboration platforms to align all efforts of ongoing and future initiatives supporting the 3 DTHC priorities. The partners will utilise their vast network of more than 1,100 members representing national, regional, and EU-wide stakeholders. The collaborative work will lead to common strategic agendas and commitments for action that will boost innovation and progress in the respective topics. A Board of Associated Experts with proven high-level competence on all key fields will support the delivery of an actionable strategic vision and recommendations for EU policy beyond 2020. | project/european |
Q6179022 | INVESTIMENTOS DE ALTA TECNOLOGIA PARA A MODERNIZAÇÃO E O REFORÇO DA ATIVIDADE EMPRESARIAL. | INVESTIMENTOS EM NOVO CICLO DE SOLDAGEM COM MÁQUINAS DE ALTA TECNOLOGIA E NOVO COMPRESSOR, COMPRA DE EQUIPAMENTOS, CONSULTORIA E SERVIÇOS DEDICADOS A INVESTIMENTOS. | project/regional |
W2059207151 | Advantages of an analysis of soil-structure interaction in a frequency domain | With the computer power available an analysis of a total soil-structure system has become possible. In this paper the advantages of an analysis performed in an frequency domain is shown: the condensation to the primary degrees of freedom, thereby conserving all the characteristic properties of the system, is straightforward; material damping based on rheological models can be considered easily; and even nonlinear problems may be investigated. The formulation is developed in a total displacement formulation, where the motion is driven by forces acting at the soil-structure interface, or more generally, at so-called interaction nodes. The total displacement formulation is compared with the classical approach, where the unknowns are the relative deformations with respect to the rigid base of the structure. These unknows are produced by inertial forces acting on the masses of the structure. In the conclusion the total displacement formulation in the frequency domain is suggested for structures with embedded elastic foundation built on a sub-grade which requires extended modeling for the mechanical representation of the structure and the sub-grade. | publication |
W1827741419 | Dietary Phosphorus Restriction in Advanced Chronic Kidney Disease: Merits, Challenges, and Emerging Strategies | Hyperphosphatemia is an independent risk factor for mortality in patients on maintenance dialysis. Since phosphorus clearance by standard three times-weekly dialysis is insufficient to balance ongoing dietary phosphorus intake, strategies to prevent absorption of dietary phosphorus are essential for attenuating increased serum levels. Dietary phosphorus binders are used widely for this purpose but dietary phosphorus restriction is relatively underutilized, most likely because of the logistical complexity of instituting and monitoring a low phosphorus diet, and for fear of worsening protein-energy wasting, which itself is a potent risk factor for mortality. In this review, we propose sustainable strategies for reducing phosphorus intake while avoiding exacerbation of protein-energy wasting. The approach is based on recognition of the dissociation between protein and phosphorus content in phosphorus-rich processed foods and the varying phosphorus bioavailability in different dietary sources. Controlling serum phosphate levels is among the most challenging aspects of day-to-day dialysis care but integration of sensible dietary interventions will likely improve phosphorus control. | publication |
US 26432508 A | 3-D video cube | The present invention is a novel, high resolution, color, three-dimensional (3-D) volumetric display system for dynamic images—the video cube. The video cube consists of an air-tight glass cube filled with a gas mixture and multiple planes of thin wires arranged in alternating orthogonal layers. These wires may be set at voltage potentials capable of producing a glow discharge at the intersection of pairs of wires. Using a computer capable of storing dynamic image data and electronic controllers capable of energizing pairs of wires appropriately at the proper time 3-D dynamic images may be formed from multiple glows between excited wire pairs. The video cube may be used to display complex real-time information from computers and other digital processors with high accuracy for unlimited number of simultaneous unaided observers. | patent |