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Influence of ethanol on fetal brain cholinergic enzyme activities. | cells exposed to ethanol only in vivo. These levels were more than 6 times greater than those of central nervous system cells never exposed to ethanol. Acetylcholinesterase (AChE) activity was significantly elevated (greater than 4-fold) in fetal brain cells when ethanol was present both in vivo and in vitro; but neither treatment alone resulted in any significant changes in AChE. These effects of ethanol on enzymes involved in acetylcholine metabolism may contribute to the different developmental neurolog | 2634855 | [
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Influence of ethanol on fetal brain cholinergic enzyme activities. | ic abnormalities associated with fetal alcohol exposure. | 2634855 | [
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Propylene-glycol-induced pulmonary hypertension in sheep. | Propylene glycol is commonly used as a vehicle for drug administration. In experiments involving the measurement of pulmonary hemodynamics; pentobarbital anesthesia routinely resulted in pulmonary hypertension in sheep. Since pentobarbital is formulated with 40% propylene glycol; we studied the pulmonary hemodynamic effects of propylene glycol in halothane-anesthetized sheep. Intravenous 40% propylene glycol (0.12 ml/kg over 3 min) rapidly increased pulmonary artery pressure (from 10 +/- 2 to 18 +/- 1 mm Hg | 2634856 | [
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Propylene-glycol-induced pulmonary hypertension in sheep. | ; p less than 0.01) and pulmonary vascular resistance (from 200 +/- 18 to 500 +/- 51 dyn.s.cm-5; p less than 0.01); pulmonary hypertension was still present 1 h later. In sheep pretreated with the selective thromboxane A2 synthesis inhibitor dazmegrel; propylene glycol did not affect pulmonary artery pressure or pulmonary vascular resistance. Propylene-glycol-induced pulmonary hypertension in sheep appears to be mediated by thromboxane A2. Both ethanol and polyethylene glycol similarly produce pulmonary hyp | 2634856 | [
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Propylene-glycol-induced pulmonary hypertension in sheep. | ertension in sheep. We conclude that vehicle control data are required for studies using propylene glycol in sheep and advise caution when propylene glycol is employed as a vehicle in clinical use. | 2634856 | [
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Inhibitory effect of [Tyr34]bPTH-(7-34)-amide on bPTH-(1-34) ability to reduce uterine contraction. | Synthetic bovine parathyroid hormone containing the 1-34 NH2-terminal amino acids [bPTH-(1-34)] inhibits uterine contraction stimulated by a variety of agonists. Previously; we reported that the parathyroid hormone analogue [Nle8; Nle18; Tyr34]bPTH-(3-34)amide [NTA-(3-34)] antagonized this effect of bPTH-(1-34) while the analogue [Tyr34]bPTH-(7-34)amide [bPTH-(7-34)] used in this study stimulated uterine contraction. However; contrary to this previous report; bPTH-(7-34) in the present study failed to initi | 2634857 | [
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Inhibitory effect of [Tyr34]bPTH-(7-34)-amide on bPTH-(1-34) ability to reduce uterine contraction. | ate a contractile response and instead resulted in an inhibitory response to the bPTH-(1-34) effect on uterine contraction in a dose-related manner. The inhibitory response of bPTH-(7-34) was further confirmed by demonstrating that this preparation of bPTH-(7-34) was capable of blocking bPTH-(1-34)-stimulated adenylate cyclase activity on particulate fractions of osteoblast-like cells from neonatal mouse calvarial. These results are consistent with those in the literature for the antagonistic effect of the | 2634857 | [
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[Height, weight and head circumference according to gestational age in newborn infants born before 35 weeks]. | A retrospective and collaborative study was done in Santiago; Chile; in order to obtain national data on birth-weight; height and head circumference of babies born at 24 to 34 weeks of gestation: 370 babies with reliable gestational age; single pregnancies and no maternal nor fetal morbidity were included in the study. Babies were born in three government and one private hospitals from 1982 to 1987. Mean birthweight; height and head circumference for each gestational age from 24 to 34 weeks are presented in | 2634858 | [
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[Height, weight and head circumference according to gestational age in newborn infants born before 35 weeks]. | tables with their S.D. and charts +/- 1.5 S.D. The national use of these tables and curves is recommended. | 2634858 | [
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[Blood pressure measurement with Doppler in normal newborn infants and infants]. | Systolic blood pressure (SBP) was measured by Doppler method in an aleatory sample of 251 healthy children from south-east Santiago Chile (131 females and 120 males) which were divided by age in five groups: 0 to 28 days (n = 5) 1 to 5 months (n = 48); 6 to 11 months (n = 48); 12 to 17 months (n = 46) and 18 to 24 months (n = 45). Great dispersion of SBP values occurred among newborn infants (range 85 to 125) in comparison with groups 1 to 5 months (105 to 130); 6 to 11 months (118 to 130). Fifty and 95 per | 2634859 | [
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[Blood pressure measurement with Doppler in normal newborn infants and infants]. | centiles were; respectively; 107 to 125; 116 to 130; 121 to 130; 118 to 130 and 120 to 130. These values were greater than those obtained by sphygmomanometry in a similar matched group of children. | 2634859 | [
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[Handedness, cerebral dysfunction and dyslexia]. | A frequency distribution of handedness and its relations with minor signs of neurological dysfunction was studied in a group of 56 dyslexic children and 56 good readers. An unusual frequency of 18% left-handed children in the dyslexic group and the high frequency of soft signs in this lefthanded children; is in concordance with recent hypothesis about the dysgenesic brain origin of dyslexia and lefthandedness; postulated by Galaburda; Geschwind and others. They suggest a distorted cortical development of th | 2634861 | [
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[Retrospective evaluation of persistent diarrhea at a primary health service]. | Information about persistent diarrhea is scarse despite the fact that it is a frequent cause of death in children who live in developing countries. The 36;358 pediatric consultations performed at a Primary Health Care Center in Southeastern Santiago in 1984 were retrospectively evaluated. Diarrheic syndromes represented 5.1% of consultations and corresponded to 909 episodes; of these; 6.3% were cases of persistent diarrhea (greater than 15 days). The highest frequency occurred among children under 2 years o | 2634862 | [
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[Retrospective evaluation of persistent diarrhea at a primary health service]. | f age (60.7%). In 68.7% of cases feces were liquid and in 37.5% mucus; pus or blood was present in stools. Persistent diarrhea was more frequent among malnourished patients (p less than 0.001) who; in turn; suffered the greatest nutritional deterioration in relation to the episode of diarrhea. Intravenous fluids were required by 23.3% of patients while 27.9% were admitted to hospital. This contrasts with patients who suffer episodes which lasted less than 15 days; who were all orally hydrated and only 7.8% | 2634862 | [
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[Retrospective evaluation of persistent diarrhea at a primary health service]. | required hospitalization (p less than 0.01). | 2634862 | [
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[Epidemiologic dynamics of scarlet fever in Chile]. | The monthly incidence of scarlet fever was studied by time-series analysis. Two types of periodic fluctuations were detected involving a bimodal short seasonal cycle and a long-term cycle whose period takes 5 years approximately. The interactions of the respiratory transmission mechanism; person to person contacts and environmental temperature would explain the seasonal cycle bimodality. The long-term cycle would be explained by asynchronic fluctuations of the fraction of population assigned to "cases" and | 2634860 | [
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[Epidemiologic dynamics of scarlet fever in Chile]. | "susceptibles". | 2634860 | [
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[Pathogenic agents in acute non-enterocolic diarrheal syndrome]. | Along a one year period 112 infants admitted with non enterocolic acute diarrhea were studied for isolation of potentially ethiologic agents; namely enteropathogenic bacteria (Salmonella; Shigella; Campylobacter; classic enteropathogenic; enteroinvasive and enterotoxigenic Escherichia coli); Rotavirus (viral RNA electrophoresis) and enteroparasites (Telemann and PAFS). The most frequently identified pathogen was rotavirus (57.8%); followed by thermo labile toxin producing Escherichia coli (19.7%). The frequ | 2634863 | [
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[Pathogenic agents in acute non-enterocolic diarrheal syndrome]. | ency of classic enteropathogenic Escherichia coli was 13.9%; that of thermo stable toxin producing Escherichia coli 5.7%; Shigella 4.1%; Campylobacter 3.3% and Salmonella 1.6%. Bacteriae were isolated from 40.2%; of patients; predominantly in summer. Enteroparasites were detected in 13.1% of the cases; Entamoeba histolytica being the most frequent. In 32.8% of the cases more than one pathogen was isolated. | 2634863 | [
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[Transient idiopathic periosteal hyperostosis with hyperproteinemia (Goldbloom syndrome)]. | The case of a 13 year old girl is presented; who developed intense pain in extremities and experienced marked weight loss after an acute upper respiratory tract infection. Roentgenograms revealed a diffuse periosteal reaction; most intensely affecting long bones. Principal laboratory findings were a slight normocytic; normochromic anemia; high erythrocyte sedimentation rate; medullar plasmocytosis and dysproteinemia; with a large increase in plasma gammaglobulin concentration. Clinical recovery and normaliz | 2634864 | [
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[Transient idiopathic periosteal hyperostosis with hyperproteinemia (Goldbloom syndrome)]. | ation of roentgenograms and laboratory parameters were observed eleven months after the acute episode; with no intervening therapeutic measures. This case matches Goldbloom's syndrome; described originally in two children in 1966. Only 3 other cases have been reported in the literature. | 2634864 | [
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[Hemangioma of the spleen in a newborn infant. Postsplenectomy course and splenic autotransplantation]. | A girl presenting with an enlargement of the spleen; thrombocytopenia and microangiopathic hemolytic anemia at birth was studied; and a splenic hemangioma was diagnosed. Total splenectomy was performed with autotransplantation of a segment of normal splenic tissue. The patient has been followed up to age 4 years. She has not presented infections and has permanently shown normal hematological values; with evidence of good function and growth of the auto implanted spleen tissue. This experience supports the u | 2634865 | [
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[Hemangioma of the spleen in a newborn infant. Postsplenectomy course and splenic autotransplantation]. | sefulness of autotransplantation of the spleen in newborns and infants aged less than 5 years that must undergo splenectomy for non malignant splenic lesions. | 2634865 | [
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[Intestinal cryptosporidiosis: a case of hospital infection]. | A hospital acquired case of human cryptosporidiosis is reported in a pediatric patient with prolonged diarrhea; whose previous investigation was negative for the agent. Cryptosporidium was isolated from feces in coincidence with admission; to the same hospital room; of an additional patient with acute diarrhea in whom infection by the same agent had been demonstrated. Infant to infant transmission in hospital wards is thus a possibility. | 2634866 | [
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[Postnatal growth of very low birth weight infants. II. Anthropometry at one year of age, a longitudinal study]. | A prospective study up to one year of age; was done in 154 newborns with birth weight less than 1;501 g at a Metropolitan Hospital of Santiago; Chile; between 1983 and 1987. The patients were divided in groups A: 44 patients with birth weight less than 1;001 g; B: 68 patients with birth weights from 1;000 to 1;250 g and C: 48 patients with birth weight 1;251 to 1;500 g. At age one year weight of group A patients was 6;724 +/- 804 g; group B 7;782 +/- 927 g and group C 7;941 +/- 903 g. Weight and height of g | 2634867 | [
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[Postnatal growth of very low birth weight infants. II. Anthropometry at one year of age, a longitudinal study]. | roup A babies at one year of age were below 2 DS of the average weight and height for normal chilean babies of the same socioeconomic status and geographic area with 3;318 g mean birth weight. Group B and C were between 1 and 2 DS. Head circumference was within normal ranges in groups B and C patients; but in group A patients if was below 2 DS of the average. | 2634867 | [
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[Dentin pins: risk evaluation and precautions]. | When large restorations are necessary; self screw-cutting dentinal pits are very useful auxiliaries. The main risks encountered during their utilization are: --perforation through periodontium--pulpal wound--dentinal cracks--weakness of mechanical properties of restorative material--corrosion--breakdown of the drill--pulpal warning up--unesthetical front restorations. The way to prevent those difficulties are: --precise clinical and radiological examinations--insertion point--direction--number--composition- | 2634868 | [
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[Surface treatment of rotary instruments with titanium nitride coating]. | An under vacuum processing is able to procure a high mechanical resistance surface coating of few microns on rotating instruments. The results show an increase of the life expectancy of the instruments and an improvement of their mechanical qualities and their resistance to corrosion. | 2634869 | [
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[Local anesthesia for children: a critical step]. | To realise a good child's dentistry; an excellent analgesia is primordial. Local anaesthesia is most useful for reliable and complete dental care on one tooth during one single appointment. But the young patient is afraid by the "ting"; making an association with disagreeable or sore souvenirs as a vaccination. First contact with the dentist is the very important; from psychological point of view; situation has to be dedramatized; from technical point of view; anaesthesia has to be not painful and efficacio | 2634870 | [
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[Local anesthesia for children: a critical step]. | us. In pedodontics; the best technical procedure is an infiltration anaesthesia. | 2634870 | [
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[The most appropriate type of flap for endodontic surgery]. | Retrograde filling consists in sealing endodontics system directly at the apical zone after surgical approach. This article is studying the best approach by flap surgery adapted to anatomo-pathological data of each case. | 2634872 | [
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[Aspergillus sinusitis of dental origin]. | Aspergillus sinusitis are not uncommon. A multiplicity of etiologic factors are involved since any foreign body introduced in the sinus can be the starting point to an aspergillus cloud. The endodontic origin is difficult to establish. The authors will review this topic through a case report. | 2634873 | [
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[The deciduous tooth. Diagnosis in pedodontics and its problems. The role of histopathology]. | Accurate diagnosis of pulpal and periodontal pathology in children is an intricate question; in fact of mixed dentures and physiological and symptomatological dissimilarity between permanent and deciduous teeth. Some figures of most frequently encountered tissue modifications of deciduous teeth are proposed in order to be considered in the way of diagnosis and therapeutics in pedodontics. | 2634871 | [
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] |
[Breast cancer in the pregnancy-puerperal cycle]. | From 1978 to 1988; 611 cases of breast cancer were seen by the Mastology Department of the Beneficência Portuguesa Hospital in São Paulo; Brazil. Thirteen (2.12%) cases were associated to pregnancy; and nine (2.4%) became pregnant after treatment. The patients were submitted to surgery and the authors waited till the end of pregnancy to perform the Rt and/or Qt. Two cases could not be submitted to any kind of treatment. Whenever tests indicated fetal maturity; the option was to perform a caesarean section; | 2634875 | [
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[Breast cancer in the pregnancy-puerperal cycle]. | and oophorectomy was performed in the most advanced cases. Among patients who became pregnant after treatment; initial cases were predominant and their pregnancies went to term with no problem. The authors compare their results to data found in literature and draw attention to anticonception in mastectomized patients. | 2634875 | [
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[Future prospect in rheumatic diseases]. | nan | 2634882 | [
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[The dissecting aorta: clinical analysis and anatomo-pathologic correlations in 30 cases]. | The authors studied 30 cases of aortic dissection performed from January 1978 to December 1987. Dissection was classified as type A (intimal tear beginning in the ascending aorta or arch) and type B (intimal tear beginning in the descending aorta). Type A predominated (66.7%). Type B dissection was most frequent in patients older than 60. Precordial pain was the main symptom in type A cases; whereas 62.5% of type B cases showed no precordial pain. Most frequent findings in type A patients were hypotension ( | 2634876 | [
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[The dissecting aorta: clinical analysis and anatomo-pathologic correlations in 30 cases]. | 45.5%); murmur of aortic regurgitation (40.0%); and dyspnea (40.0%); whereas in type B patients; most frequent findings were hypertension (28.6%); and pulse deficit (42.9%). The major differential diagnosis for type A was myocardial infarction (43.8%); and for type B; peripheral artery failure (25.0%) and acute pneumonia (25.0%). 24 patients (80.0%) had hemorrhage. Hemorrhage into the pericardial sac occurred in 68.8% of type A patients; and 50.0% of type B patients had retroperitoneal hemorrhage. Systemic | 2634876 | [
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[The dissecting aorta: clinical analysis and anatomo-pathologic correlations in 30 cases]. | hypertension; atherosclerosis; medial cystic necrosis and endocrine disorders were considered predisposing factors for both type of dissection. A case of dissection after aortic valve replacement associated with ascending aorta tubular graft replacement was observed in this series. In type A patients; average survival was 6.3 days; and in type B; 11.1 days. The major cause of death was hemorrhage (70.0%). | 2634876 | [
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[Calcium regulating hormone in the pathological changes of bone in rheumatoid arthritis]. | To further elucidate the pathogenesis of calcium regulating hormones and bone Gla-protein (BGP) on the deteriorated bone changes in rheumatoid arthritis (RA); the degree of the appendicular bone atrophy; using microdensitometry method in patients with RA; and the concentrations of midchain mainly recognized parathyroid hormone (p-PTH1-84; intact parathyroid hormone (in-PTH1-84) and BGP in sera of patients with RA were measured. With concomitant progression in X-ray stage in RA; the levels of p-PTH1-84; in-P | 2634883 | [
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[Calcium regulating hormone in the pathological changes of bone in rheumatoid arthritis]. | TH1-84; BGP; 25 (OH) D; and 24; 25 (OH)2D were significantly increased in sera of RA patients. The levels of 1;25 (OH)2D were not shown significant differences among RA patients classified by bone stage. These results might be concluded that the pathogenesis of the deteriorated bone change in RA seemed to be implicated in hyper-turnover bone presumably caused by the actions of parathyroid hormone and abnormal vitamin D metabolism. | 2634883 | [
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[In vivo T-lymphocyte activation in patients with multiple sclerosis]. | Patients with multiple sclerosis present changes in lymphocyte subtypes in the peripheral blood. In this study; the authors demonstrate that patients with clinical activity or under an episode show marked increases in the percentages of activate lymphocytes detected through monoclonal antibodies against transferrin and interleukin 2 receptors. | 2634877 | [
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[Association of immunomodulators and HLA antigens in rheumatoid arthritis]. | We studied the association between HLA antigens and clinical response to immunomodulators or the toxic effects of immunomodulators in 191 patients with rheumatoid arthritis (RA). All patients received nonsteroidal anti-inflammatory drugs. Fifty-seven patients were treated with auranofin; 61 patients with penicillamine and 45 patients with lobenzarit. We found that HLA-Cw 1 is significantly (p less than 0.05) associated with a substantial clinical response to auranofin in RA patients (65% vs 33% of Cw 1-nega | 2634884 | [
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[Association of immunomodulators and HLA antigens in rheumatoid arthritis]. | tive patients). We observed that HLA-DR 4 is a risk factor for the occurrence of toxic reactions to penicillamine (45% vs 21% of DR 4-negative patients: p less than 0.05) and that HLA-DRw 9 is a risk factor in the case of lobenzarit (62% vs 32% of DRw 9-negative patients: p less than 0.05). HLA-A 24-positive patients with RA experienced a low frequency of side effects from auranofin (16% vs 37% of A 24-negative patients: p less than 0.05). HLA-A 2 or Cw 7-positive patients with RA experienced a low frequenc | 2634884 | [
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[Association of immunomodulators and HLA antigens in rheumatoid arthritis]. | y of side effects from penicillamine (12% vs 49% of A 2-negative patients: p less than 0.01; 17% vs 46% of Cw 7-negative patients: p less than 0.05). Our data demonstrated that HLA antigens are significantly associated with a clinical response to immunomodulators and the toxic effects of immunomodulators in patients with RA. | 2634884 | [
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[Clinical study on two cases of progressive systemic sclerosis with anti Wa antibody]. | It is well known that patients with progressive systemic sclerosis (PSS); as well as other autoimmune disease; have various kinds of autoantibodies. We presented two PSS patients with anti Wa antibody; which had recently been reported as a new anti cytoplasmic antibody in only one case with PSS. Our first case; 49 years old female had clinical features of arthralgia; Raynaud's phenomenon; sclerodactyly; transient myalgia and sicca complex. Her laboratory findings showed hypergammaglobulinemia (1.9 g/dl); po | 2634885 | [
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[Clinical study on two cases of progressive systemic sclerosis with anti Wa antibody]. | sitive RAHA (1: 640) anti Wa antibody (1: 256); and anti SS-A antibody (1: 256). Second case; 64 years old female had also clinical features of Raynaud's phenomenon; sclerodactyly; dysphagia; dyspnea on exertion and dry mouth. Furthermore lung fibrosis and dysmobility of upper GI tract were observed. FANA (1: 20) was detected as nucleolar pattern; and the titer of anti Wa antibody was 1: 64. Clinical findings of myositis were not seen in both cases. This study suggested that anti Wa antibody might be one of | 2634885 | [
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[Anti-HIV positivity at a reference laboratory]. | nan | 2634881 | [
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[A case of ankylosing spondylitis complicating Crohn's disease]. | A 20-year-old man; who had suffered from ankylosing spondylitis for about 1 year; was admitted to our hospital due to melena and syncope. Physical examination revealed tenderness of abdomen and sacroiliac joint; and decreased spinal mobility. X-ray examination showed sacroiliitis and squaring of vertebral bodies. RA test and RAHA; negative; CRP; strongly positive; HLA-B 27 positive. Intestinal barium enema revealed skipping longitudinal fissure at terminal ileum; and a biopsy specimen of the colon revealed | 2634886 | [
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[A case of ankylosing spondylitis complicating Crohn's disease]. | non-caseating granuloma. The association of ankylosing spondylitis and Crohn's disease has widely been known in Europe and United States; but this is the first case reported in detail in Japan; where incidences of both diseases were much lower than those found in Caucasians. | 2634886 | [
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An evaluation of school dental health education programmes. | nan | 2634896 | [
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[Primary intravelar vestibuloplasty--adaptation of surgical modification of the anatomical defect]. | Oro-nasal fistulae often occur after the primary closure of the hard and soft palate cleft and in particular at the junction between the hard and soft palate. This is the area where maximal tension is exerted during the intravelar veloplasty closure procedure. Six surgical modifications of the primary intravelar veloplasty technique are described and each is specifically adapted according to the existing anatomical form and defect of the cleft soft palate; so that the occurrence of an oro-nasal fistula may | 2634897 | [
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[Primary intravelar vestibuloplasty--adaptation of surgical modification of the anatomical defect]. | be prevented. The surgical procedures may be divided into two main groups; namely those which are based on a localized swivel flap and those where remote flaps are used. | 2634897 | [
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[Three-dimensional architecture of the connective tissue papillae of the mouse tongue as viewed by scanning electron microscopy]. | The morphological relationship between lingual papillae and underlying connective tissue papillae of mouse was studied because it is conceivable that the differentiation of epithelium may be affected by its connective tissue. Tongues of adult male mice were fixed in formol or Karnovsky's fixative. After removal of the epithelium by long-term hydrochloric acid treatment at room temperature; the surface of the connective tissue papillae was observed by scanning electron microscopy. Connective tissue papillae | 2634898 | [
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[Three-dimensional architecture of the connective tissue papillae of the mouse tongue as viewed by scanning electron microscopy]. | that were fungiform in shape and which were distributed at the anterior part of the tongue showed barnacle-like protrusion after removal of the epithelium. Their surface was covered by numerous long filaments running vertically and there was a round depression on the top of each fungiform papilla that may be found to correspond to a taste bud when the results of light and electron microscopy are compared. Filiform papillae in a narrow sense were closely distributed in the anterior part of the tongue. They h | 2634898 | [
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[Three-dimensional architecture of the connective tissue papillae of the mouse tongue as viewed by scanning electron microscopy]. | ad a tapered tip declining posteriorly. Each filiform connective tissue papilla was conical in shape and had a round depression that slightly declined antero-downward; and a long narrow depression ran along the anterior edge of each connective tissue papilla. Large conical papillae which distributed at the anterior margin of the intermolar prominence had shovel-like connective tissue papillae which had a depression at the posterior surface unlike that of the filiform papillae. Branched papillae distributed | 2634898 | [
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[Three-dimensional architecture of the connective tissue papillae of the mouse tongue as viewed by scanning electron microscopy]. | in the posterior part of the prominence had a depression at the anterior surface. Under the light microscope; numerous keratohyaline granules were seen to be contained only in the posterior epithelial cell line of the large conical papillae distributed in the anterior margin of the prominence; while these granules were found only in the anterior epithelial cell line of both filiform and branched papillae. It became clear that the axes of each connective tissue papilla of large conical papillae distributed r | 2634898 | [
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[Three-dimensional architecture of the connective tissue papillae of the mouse tongue as viewed by scanning electron microscopy]. | adically around a single midpoint. Connective tissue papillae of vallate papillae had a beehive-like shape and in follicate papillae there were several vertical elliptical gaps; seen when the epithelium was peeled from the connective tissue. | 2634898 | [
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[Difference in the postnatal development of the layer structures in the phylogenetically different cat cerebellar cortices]. | Although it has long been accepted that the structure of the cerebellar cortex is the same all over its areas; some of the recent studies indicated that there are regional differences in the time course of development of the cortical layer structures as well as in its cytoarchitecture. The cerebellum consists of 3 phylogenetically different areas; archi-; paleo- and neocerebellum; which deals with vestibular; spinal cord and cerebral cortical activities respectively. The development of the structures of cer | 2634899 | [
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[Difference in the postnatal development of the layer structures in the phylogenetically different cat cerebellar cortices]. | ebellar cortex occurs mostly after birth in the altrical animals; and the control of the posture and movement takes place faster in the trunk than in the extremities in such animals. It could be expected that the postnatal development occurs faster in the phylogenetically older parts than in the newer ones. To elucidate the above mentioned assumption; post-natal development of the cerebellar cortical structures was studied; cytoarchitectonically and cell morphologically; using cats from birth to the adult s | 2634899 | [
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[Difference in the postnatal development of the layer structures in the phylogenetically different cat cerebellar cortices]. | tate. The external granular layer increased in thickness from birth to 2-9th postnatal days; then decreased gradually; and almost disappeared by the 63rd postnatal day. While the molecular and the internal granular layers increased in thickness gradually after birth; and reached the adult level by the 63rd postnatal day. Cytoarchitectonically; postnatal development took place faster in the archicerebellum; next in the paleocerebellum and slowest in the neocerebellum. Silver impregnation study showed the fir | 2634899 | [
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[Difference in the postnatal development of the layer structures in the phylogenetically different cat cerebellar cortices]. | st dendritic arborization of the Purkinje cell appeared on the 7th postnatal day in the arch- and paleocerebellum; while the same phenomenon was observed on the 14th postnatal day in the neocerebellum. The above observations confirmed our assumption that phylogenetically older parts of the cerebellar cortex have faster postnatal development than the newer ones. This is in agreement with the fact that the function of the neuronal activity in these phylogenetically older parts occurs earlier than in the newer | 2634899 | [
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[Effect of blockage of the afferent lymphatic vessels on the development of popliteal lymph nodes in the rat]. | The effect of blockage of the afferent lymphatic vessels on the development of popliteal lymph nodes in the rat was studied. The afferent lymphatic vessels to each popliteal node were surgically interrupted at the lowest edge of the popliteal fossa at 3; 7 or 28 days after birth and the popliteal nodes were obtained from treated animals at 4; 8 or 16 weeks after the operation. At 7 days after birth; each popliteal node was small and weighed 0.2 mg. Its parenchyma consisted of reticular cells and a small num | 2634900 | [
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[Effect of blockage of the afferent lymphatic vessels on the development of popliteal lymph nodes in the rat]. | ber of dispersed lymphoid elements. Four weeks after birth; each node weighed 4-5 mg; and its parenchyma comprised two layers; an outer continuous layer of peripheral cortex containing 40-50 lymph follicles and an inner discontinuous layer of deep cortex made up of 4-5 deep cortical units. At 10-12 weeks after birth; each node weighed about 10 mg and showed full structural development; the peripheral cortex contained 100-130 lymph follicles and the deep cortex consisted of 4-6 well developed units. The popl | 2634900 | [
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[Effect of blockage of the afferent lymphatic vessels on the development of popliteal lymph nodes in the rat]. | iteal node was drained by 4-6 afferent lymphatic vessels; which opened into the subcapsular sinus of the node. Each lymphatic opening was topographically associated with a respective deep cortical unit; as previously described by Bélisle and Sainte-Marie (1982). In animals treated at 3 or 7 days after birth; the development of the popliteal nodes was considerably inhibited. Four weeks after surgery; each node showed 10-30 lymph follicles in the peripheral cortex and 1-3 small units in the deep cortex. Sixte | 2634900 | [
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[Effect of blockage of the afferent lymphatic vessels on the development of popliteal lymph nodes in the rat]. | en weeks after surgery; the node weighed about 4 mg and its cortex exhibited about 50 lymph follicles in the peripheral cortex and only 2 units in the deep cortex. The popliteal nodes of the treated animals generally received 2 afferent lymphatic vessels. In animals treated at 4 weeks after birth; the popliteal nodes showed no gain in weight for following 16 weeks. Four weeks after surgery; each node usually had 4-5 deep cortical units and 50-60 lymph follicles. Thereafter; some units and their overlaying p | 2634900 | [
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[Effect of blockage of the afferent lymphatic vessels on the development of popliteal lymph nodes in the rat]. | eripheral cortex underwent atrophy; while others persisted. Sixteen weeks after surgery; the popliteal node showed only 2 deep cortical units and 50-60 lymph follicles; and was drained by 2 afferent lymphatic vessels. Surgical interruption of the afferent lymphatic vessels to the popliteal node at the lowest edge of the popliteal fossa did not obliterate all the draining lymphatic vessels ; but reduced the number of vessels opening into the node.(ABSTRACT TRUNCATED AT 400 WORDS) | 2634900 | [
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Effect of calcium influx blocker verapamil on adriamycin-induced cytotoxicity in leukemia cells in vitro. | The effect of verapamil (calcium influx blocker) on adriamycin-induced cytotoxicity against sensitive and resistant subline of K 562 acute myelogenous human leukemia cells has been evaluated. Verapamil by itself at a concentration of 0.5 microgram/ml did not affect the cell growth. It was found that the nontoxic concentration of verapamil moderately enhanced adriamycin cytotoxicity against K 562 cells; showing enhancement ratio of 1.3-1.4 according to the schedule used. A significant enhancement of adriamyc | 2634901 | [
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Effect of calcium influx blocker verapamil on adriamycin-induced cytotoxicity in leukemia cells in vitro. | in cytotoxicity (enhancement ratio of 5.8) was observed when verapamil and adriamycin were administered simultaneously against resistant subline of K 562/ADM cells. The results obtained give grounds to assume that verapamil could be used to overcome drug resistance in tumor cells. | 2634901 | [
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Effect of verapamil on renin-angiotensin-aldosterone system, urinary 6-keto prostaglandin F1 alpha and aldosterone response to metoclopramide in normal man. | Seven healthy male volunteers were studied at the end of 7 days placebo period and after 7 days treatment with verapamil (120 mg twice daily). Verapamil increased significantly plasma renin activity and urinary excretion of 6-keto prostaglandin F1 alpha without significant modification of plasma aldosterone. Metoclopramide (10 mg i. v.) induced a significant increase of plasma aldosterone with the peak values 15 min after the injection of the drug. The results indicate that verapamil does not lead to second | 2634902 | [
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Effect of verapamil on renin-angiotensin-aldosterone system, urinary 6-keto prostaglandin F1 alpha and aldosterone response to metoclopramide in normal man. | ary hyperaldosteronism which is characteristic of most other vasodilators. The increase of prostacyclin; measured as 6-keto prostaglandin F1 alpha can contribute to the efficacy of verapamil in patients with ischemic heart disease and hypertension. The present study suggests that the aldosterone response to metoclopramide is not directly dependent on calcium; but an indirect effect of calcium through renin-angiotensin system cannot be excluded. | 2634902 | [
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Plasma erythropoietin activity in diabetes patients, studied by determining the 59Fe incorporation in posthypoxic polycythemic mice. | The plasma erythropoietin activity in diabetes patients was studied using methods for biological testing on posthypoxic polycythemic mice; based on the incorporation of 59Fe in the newly-formed red blood cells of the animals. The data are read on an automatic scintillation gamma-counter. Considerably higher erythropoietin activity of the plasma obtained from diabetics (p less than 0.01) compared with clinically health individuals has been obtained; as well as a statistically significant difference in the pe | 2634903 | [
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Plasma erythropoietin activity in diabetes patients, studied by determining the 59Fe incorporation in posthypoxic polycythemic mice. | rcentage of 59F incorporated in the newly-formed erythrocytes of the animals treated with that plasma; compared with the animals treated with saline. A dependence has been found between the chronic hyperglycaemia and the plasma erythropoietin level. | 2634903 | [
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Ovariectomy- and sex hormone-induced changes in the excitability of the CNS: an assessment by EEG paroxysmal activity and behaviour. | The changes in the excitability of the CNS were investigated in female rats after ovariectomy and subsequent substitution with ovarial hormones (estradiol; progesterone and combination of both steroids). The excitability of the CNS was evaluated by the spontaneous EEG paroxysmal activity and by some behavioural features (alertness; exploration and quiet wakefulness). The experimental results showed that the removal of the sex hormone secretion for a long-term period causes a discrepancy between the decrease | 2634904 | [
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Ovariectomy- and sex hormone-induced changes in the excitability of the CNS: an assessment by EEG paroxysmal activity and behaviour. | of behavioral patterns and increased excitability in CNS. The substitution with physiological doses of estradiol and progesterone elicits further increase of the sensitivity of the CNS. The latter was demonstrated by an increase of the excitability both in quiet wakefulness and alertness. | 2634904 | [
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Effect of potassium ethylxanthogenate on the toxicity and analgesic effect of acetaminophen. | The effect of potassium ethylxanthogenate (PEX) on the toxicity and the analgesic effect of acetaminophen (AAP) were investigated on male albino mice. PEX in a dose of 80 mg/kg body weight; administered subcutaneously or orally one hour before AAP; or simultaneously with it; induces prolongation of the survival of the experimental animals and increases LD50 of AAP. The protective effect of PEX (s.c. and p.o.) is more pronounced when this agent is introduced one hour before AAP (i.p. and p.o.); compared with | 2634905 | [
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Effect of potassium ethylxanthogenate on the toxicity and analgesic effect of acetaminophen. | the simultaneous administration; and when it is applied orally; compared with the subcutaneous administration. The average lethal dose of the combination (AAP p.o. + PEX p.o. 1 hour previously) increases 2.57 times after observation for 7 days; compared with that of AAP. Although it does not possess its own analgesic effect; PEX potentiates the analgesic effect of AAP (which is more pronounced for the low AAP doses) and reduces its average effective dose. After 14-day administration; AAP potentiates its ow | 2634905 | [
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Effect of potassium ethylxanthogenate on the toxicity and analgesic effect of acetaminophen. | n analgesic effect in the lower doses. The potentiating effect of PEX on the analgesic effect of AAP is similar on the first and on the 14th day of the treatment. The principal mechanism through which PEX decreases the toxicity and potentiates the analgesic effect of AAP is assumed to be the inhibition of its metabolism by inhibition of the cytochrome P-450-linked monooxygenases; not ruling out the possibility of a certain effect on the AAP absorption. | 2634905 | [
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