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drug_combination | What is the drug combination mentioned in the following sentence? He was initially treated with combination chemotherapy regimen of vincristine , actinomycin-D and cyclophosphamide ( VAC therapy ) . | vincristine cyclophosphamide actinomycin-D are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? However , when a lung mass was noted two months later , he started to receive combination chemotherapy consisting of cyclophosphamide , adriamycin , vincristine , and prednisolone every three months . | cyclophosphamide vincristine prednisolone adriamycin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? We used MCF-7 and MDA-MB231 breast cancer cells incubated with Curcumin and Quercetin for 24h , in the absence and presence of Somatostatin , at their EC50 concentrations , to evaluate membrane fatty acid-based functional lipidomics together with the follow-up of EGFR and MAPK signaling pathways . | Curcumin Somatostatin Quercetin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Following corneal scrapings and culture , topical 0.5 % moxifloxacin and 0.5 % tobramycin were administered hourly . | moxifloxacin tobramycin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Combination treatment with cetuximab and nystatin selectively increased cetuximab uptake by tumor tissues , translating into potentiated antitumor efficacy of cetuximab in vivo ( A431 and A549 tumors ) . | cetuximab nystatin are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? The effects of combination therapy with chenodeoxycholic acid ( CDCA ) and simvastatin on serum cholestanol , low-density lipoprotein ( LDL ) cholesterol , and lathosterol levels were investigated in seven adult patients with cerebrotendinous xanthomatosis ( CTX ) who were on long-term treatment with CDCA . | chenodeoxycholic simvastatin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Paclitaxel ( Taxol ; Bristol-Myers Squibb Company , Princeton , NJ ) has been demonstrated to be highly effective in treating patients with advanced breast cancer , including those with anthracycline-resistant breast cancer , a fact that has led to efforts to combine paclitaxel and anthracyclines . | paclitaxel anthracyclines are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Additivity , synergy , or competition was observed with MIS and rapamycin , AzadC , doxorubicin , cisplatin , and paclitaxel , suggesting that MIS in combination with selective targeted therapies might achieve greater activity against ovarian cancer than the use of each individual agent alone . | rapamycin MIS are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Several first-line phase III trials , as well as ongoing trials for which only preliminary results have been published , have fueled debates on the optimal dose and schedule ; these have focused not only on weekly vs q3-weeks paclitaxel , but also on other modifications and the advisability of adding bevacizumab . | paclitaxel bevacizumab are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The primary goal was achieve the correct estimation of the target plasma area against the topotecan concentration-time curve ( AUC ) in a 5 day course of cladribine followed by monitored topotecan in pediatric patients with recurrent/refractory AML . | cladribine topotecan are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? In patients with NPSLE , the use of high-dose corticosteroids is recommended in combination with immunosuppressants , such as mycophenolate mofetil and intravenous cyclophosphamide pulse therapy . | mycophenolate corticosteroids are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Thirty-three women diagnosed with metastatic breast cancer participated in a phase 1 clinical trial of a new combination of cyclophosphamide ( CTX ) and mitoxantrone ( MXT ) , with dose escalation of paclitaxel . | cyclophosphamide mitoxantrone paclitaxel are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? These studies suggest a slight advantage to the combined approaches that contain flutamide and bicalutamide , but the lack of dramatic differences in outcome makes monotherapy reasonable , especially in patients with more indolent disease . | flutamide bicalutamide are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? We examined the feasibility and safety of using paclitaxel and trastuzumab as maintenance therapy after high-dose chemotherapy ( HDC ) with autologous hematopoietic stem cell transplantation ( AHST ) for patients with HER2-positive metastatic breast cancer . | paclitaxel trastuzumab are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Dual antiplatelet therapy with aspirin and clopidogrel ( the preferred thienopyridine because of its superior hematologic safety ) is recommended for at least 4 weeks to prevent subacute stent thrombosis with bare-metal stents and 3 to 6 months to prevent late-stent thrombosis with drug-eluting stents . | aspirin clopidogrel are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Furthermore , in non-metastatic castration-resistant prostate cancer ( M0 CRPC ) , two second-generation anti-androgens , apalutamide and enzalutamide , when used in combination with ADT , have demonstrated a significant benefit in metastasis-free survival . | apalutamide ADT are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Phase Ib Study of the Oral Proteasome Inhibitor Ixazomib ( MLN9708 ) and Fulvestrant in Advanced ER+ Breast Cancer Progressing on Fulvestrant . | Ixazomib Fulvestrant are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Pharmacokinetic studies showed that chronic lymphocytic leukemia involving more than 80 % of the bone marrow at study start was associated with lower trough concentrations of alemtuzumab and rituximab , and that higher trough serum concentrations of alemtuzumab were associated with complete bone marrow clearance . | alemtuzumab rituximab are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Compared with risedronate alone , at 6 months , risedronate plus atorvastatin produced significantly greater increases in the bone mineral density of the lumbar spine ( 1.58 % versus 0.75 % , p < 0.05 ) . | risedronate atorvastatin are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Patients registered with the German ACC Registry with refractory ACC progressing after cytotoxic therapies were offered treatment with bevacizumab ( 5 mg/kg body weight i.v . every 21 days ) and oral capecitabine ( 950 mg/m(2 ) twice daily for 14 days followed by 7 days of rest ) in 2006 - 2008 . | bevacizumab capecitabine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Patients who had pathologically been proven to have measurable lesions were treated with paclitaxel ( 200 mg/m(2 ) for 3 h ) and carboplatin [ area under the concentration-time curve ( AUC = 6 ) ] on day 1 and in 21 day cycles . | paclitaxel carboplatin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Eligible patients received ramucirumab ( 10mg/kg ) + dacarbazine ( 1000 mg/m(2 ) ) ( Arm A ) or ramucirumab only ( 10mg/kg ) ( Arm B ) every 3 weeks . | ramucirumab dacarbazine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The aim of this study was to investigate the mutagenic and antigenotoxic effects of different doses of the flavonoid , apigenin , alone and in combination with the antitumor drugs , cyclophosphamide and doxorubicin , in vitro and in vivo . | apigenin doxorubicin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? More effective regimens are urgently needed for squamous cell carcinoma of esophagus ( SCCE ) , therefore , we conducted a phase I/II trial of a combination of docetaxel , platinum , and fluorouracil ( TPF ) for treating metastatic SCCE . | docetaxel platinum are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Gemcitabine with cyclosporine or with tacrolimus exerts a synergistic effect and induces tolerance in the rat . | Gemcitabine cyclosporine are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? We determined the effects of diclofenac sodium , octreotide , and their combination on extrapancreatic organ injuries in caerulein-induced acute pancreatitis in mice . | diclofenac octreotide are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Caspofungin and amphotericin B association has been shown to be synergistic in vitro and effective in murine models . | Caspofungin amphotericin are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Canine leishmaniosis is most frequently treated with the drugs meglumine antimoniate , allopurinol , amphotericin B , or a combination of meglumine antimoniate and allopurinol . | meglumine allopurinol are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Haloperidol , carbamazepine and levomepromazine were then discontinued . | Haloperidol carbamazepine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Recent clinical work has questioned the safety of a combined therapy of oral quinidine and intravenous verapamil , because some patients were reported to react with severe hypotension probably due to drug interactions with vascular alpha-adrenergic receptors . | quinidine verapamil are the drug combinations. No need for context. It is a NEG combination. |
drug_combination | What is the drug combination mentioned in the following sentence? To increase the dose-intensity of two drugs in metastatic breast cancer , we tested the feasibility , in phase I studies , of two schedules of epirubicin ( E ) and cyclophosphamide ( C ) - sequential ( E-- > C ) and alternating ( E/C ) - with respect to the standard combination ( EC ) . | epirubicin cyclophosphamide are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? On February 3 , 2015 , the FDA granted accelerated approval to palbociclib ( IBRANCE , Pfizer Inc. ) , an inhibitor of cyclin-dependent kinases 4 and 6 ( CDK4 and CDK6 ) , for use in combination with letrozole for the treatment of postmenopausal women with estrogen receptor (ER)-positive , HER2-negative advanced breast cancer as initial endocrine-based therapy for their metastatic disease . | palbociclib letrozole are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? a combination treatment : estramustine phosphate , cyproterone acetate or estrogens plus bromocriptine . | estramustine cyproterone are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Hormone induced elevations in temperature and possibly other unidentified factors during thyroid crisis may facilitate the triggering of MH following halothane and succinylcholine challenge . | halothane succinylcholine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Mitomycin C plus vinblastine is an effective and well-tolerated regimen for anthracycline resistant cancer . | Mitomycin vinblastine are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? An angiotensin 2 type 1 receptor blocker , olmesartan , and a calcium channel blocker , azelnidipine , possess not only an antihypertensive effect but also an antioxidative effect and other beneficial effects . | olmesartan azelnidipine are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Forty patients with metastatic breast cancer who had received no previous cytotoxic therapy were treated with a combination chemotherapy program CMF ( P ) , which included methotrexate , 60 mg/m2 , and 5-fluorouracil , 700 mg/m2 intravenously on the first and eighth days , in addition to cyclophosphamide , 100 mg/m2 , and prednisone , 40 mg/m2 , by mouth daily from the first to the fourteenth day of a 28-day cycle . | methotrexate cyclophosphamide prednisone 5-fluorouracil are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? At present , it seems to us that progress has not been made since Grignani reported a phase II cohort trial of sorafenib and sorafenib combined with everolimus for advanced osteosarcoma , which , in a sense , have become a milestone as a second-line therapy for osteosarcoma . | sorafenib everolimus are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Thirteen patients with interstitial cystitis diagnosed by the NIH criteria were treated with intravesical electromotive administration of lidocaine and dexamethasone followed by cystodistention . | lidocaine dexamethasone cystodistention are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Drug therapy included omega-3 fish oil , extended-release niacin , colesevelam hydrochloride , and a fixed combination of 10-mg ezetimibe and 40-mg simvastatin . | omega-3 niacin colesevelam hydrochloride ezetimibe simvastatin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Twenty-one Japanese colorectal cancer patients received intravenous FOLFIRI ( bolus irinotecan , folinic acid , and fluorouracil followed by 46-hour fluorouracil infusion ) followed by bevacizumab ( 5 mg/kg ) in Cycle 1 . | irinotecan folinic acid fluorouracil fluorouracil bevacizumab are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Patients received vinorelbine starting at 20 mg/m(2 ) ( to 25 mg/m(2 ) ) and carboplatin area under the curve ( AUC ) 2.5 in divided-doses , both given on Days 1 and 8 every 21-day cycle for up to 6 cycles or until disease progression . | vinorelbine carboplatin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Dexamethasone exhibited the highest effect on paclitaxel anti-tumor activity , in a dose-dependent fashion . | Dexamethasone paclitaxel are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? We therefore explored the in vitro combination of amphotericin B with itraconazole against 14 clinical Aspergillus fumigatus isolates ( 9 itraconazole susceptible and 5 itraconazole resistant ) with a colorimetric broth microdilution checkerboard technique using two drug interaction models able to explore complicated patterns of interactions : the response surface analysis of Bliss independence and the isobolographic analysis of Loewe additivity zero interaction theories . | amphotericin itraconazole are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? This study evaluated the safety and efficacy of inotuzumab ozogamicin ( INO ) , a targeted humanized anti-CD22 antibody conjugated to calicheamicin , plus rituximab ( R-INO ) every 3 weeks , up to six cycles , followed by high dose therapy and autologous stem cell transplant ( HDT-aSCT ) in patients with high-risk relapsed/refractory diffuse large B-cell lymphoma ( DLBCL ) . | inotuzumab rituximab HDT-aSCT are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? These are the first 2 reports of successful treatment of this condition by use of a combination of methylprednisolone and mycophenolate mofetil , and , in 1 of the cases , additional medication with intravenous immunoglobulin . | methylprednisolone mycophenolate are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? In conclusion , concurrent introduction of ATGAM and tacrolimus is a promising therapeutic combination for GVHD refractory to steroids and cyclosporine . | ATGAM tacrolimus are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Comparison of geometric least-squares mean PK parameters between arms showed no impact of pertuzumab on the PK of trastuzumab or docetaxel . | pertuzumab trastuzumab are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? We proved experimentally the use of ECEEM for multiplex determination of kinetic parameters describing weak ( 3 mM > K(d ) > 80 μM ) and fast ( 0.25 s ≥ τ ≥ 0.9 ms ) noncovalent interactions between four small molecule drugs ( ibuprofen , S-flurbiprofen , salicylic acid and phenylbutazone ) and α- and β-cyclodextrins . | ibuprofen β-cyclodextrins are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? We evaluated the stem cell mobilization regimen of high-dose ifosfamide plus etoposide in 32 patients with epithelial ovarian cancer , who had a positive second-look laparatomy or recurrent disease . | ifosfamide etoposide are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Combinations of alkylating agents and fludarabine or cladribine are also synergistic in producing significantly enhanced activity against refractory lymphoid malignancies , but at the cost of increased haematological toxicity . | alkylating agents fludarabine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The pharmacodynamic effects of single doses of trazodone ( 100 mg ) , amitriptyline ( 50 mg ) or placebo either alone or with ethanol ( 0.5 ml/kg ) were investigated in 6 healthy volunteers in a double-blind crossover study . | trazodone ethanol are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? A 70-year-old Asian man was diagnosed with PVT two months after initiating 5-fluorouracil/leucovorin , irinotecan , and bevacizumab therapy for rectal cancer with liver metastases . | 5-fluorouracil/leucovorin irinotecan bevacizumab are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Results of cell viability assays revealed that treatment with a combination of imatinib and chemotherapy agents irinotecan or 5‑Fu synergistically inhibited cell growth , compared with treatment with any of these drugs alone . | imatinib irinotecan are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? The combination of a fluoropyrimidine ( 5-fluorouracil or capecitabine ) with either oxaliplatin or irinotecan has been widely accepted as standard cytotoxic chemotherapy for either the first- or second-line treatment of mCRC . | fluoropyrimidine oxaliplatin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Utilizing this data , we suggest that nivolumab plus ipilimumab and cabozantinib may be favored for first-line treatment of specific populations of older patients . | nivolumab ipilimumab cabozantinib are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? The aim of this study was to evaluate all E. coli positive blood cultures collected during a 4-y period in a haematological department using piperacillin plus netilmicin for empiric treatment of febrile episodes . | piperacillin netilmicin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Thirty-five percent ( 6 of 17 ) of the patients receiving docetaxel alone and 53 % ( 19 of 36 ) of those receiving docetaxel and thalidomide have had a PSA decrease of at least 50 % . | docetaxel thalidomide are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Reduction of ASS1 expression by siRNA significantly sensitized mesothelioma spheroids to the pro-apoptotic effects of bortezomib and of cisplatin plus pemetrexed . | pemetrexed cisplatin are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? In conclusion , the combination of thalidomide and cyclosporine in subtherapeutic doses may be useful for the treatment of skin allografts . | thalidomide cyclosporine are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Rats were subchronically primed with nicotine , clozapine or saline . | nicotine clozapine saline are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? New agents , such as taxane , irinotecan and oxaliplatin , combined with old agents , such as cisplatin and 5-FU , are currently under evaluation to further improve treatment outcomes . | taxane cisplatin 5-FU are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? One group was given enalapril ( EN ) 50 mg/l dissolved in the drinking water ; the second received lovastatin ( L ) 15 mg/kg given daily by gavage ; the third received both agents ; the fourth was left untreated , and the final group received no puromycin and served as the control group . | enalapril lovastatin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Using the Killing-curve method , we tested the in vitro bactericidal activity of fosfomycin alone or in combination with vancomycin or teicoplanin at a concentration of 8 microg/mL , that is easily achievable in serum at standard dosing regimens , against seven methicillin-resistant Staphylococcus aureus strains , isolated from patients with well documented device-associated infections unresponsive to or relapsing after glycopeptide therapy . | fosfomycin vancomycin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Combination therapy with mitomycin , tamoxifen , and UFT proved to be an effective postoperative chemoendocrine therapy for stage II , ER-positive breast cancer . | mitomycin tamoxifen UFT are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? The remaining 76 patients did not receive anti-thymocyte globulin but were given cyclosporine A and methotrexate or mycophenolate mofetil ( group 3 ) . | cyclosporine methotrexate are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Propranolol significantly decreased the maximum plasma concentration ( Cmax ) and area under the plasma concentration-time curve ( AUC ) of lacidipine ( by 38 % and 42 % , respectively ) whereas lacidipine significantly increased the Cmax and AUC of propranolol ( by 35 % and 26 % , respectively ) ; neither the time to maximum plasma concentration ( tmax ) nor the terminal half-life ( t 1/2 ) were affected . | Propranolol lacidipine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The patient received chemotherapy comprising vincristine , actinomycin D , doxorubicin , cisplatin , and cyclophosphamide . | vincristine doxorubicin cyclophosphamide actinomycin cisplatin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Because gemcitabine has been considered a standard treatment for advanced pancreatic cancer for the past decade , several randomized trials have tested the combination of gemcitabine plus a second agent , including platinum based agents , topoisomerase inhibitors , taxanes , bevacizumab and cetuximab , as biologically " targeted " agents . | gemcitabine bevacizumab are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? No synergism was found against Pneumococci and Meningococci but also no antagonism of the lower MIC and MBC values seen with ampicillin and penicillin G. The combination of chloramphenicol with either penicillin or ampicillin constitutes a clinically successful therapeutic regimen which is now also proven by in vitro investigations . | ampicillin penicillin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Bendamustine is effective both with rituximab and as a monotherapy in rituximab-refractory patients . | Bendamustine rituximab are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? The effects of multiple combination chemotherapy with vincristine , cyclophosphamide ( Endoxan ) , methotrexate , 5-fluorouracil , adriamycin and prednisolone ( VEMFAH ) for advanced breast cancer . | vincristine cyclophosphamide methotrexate 5-fluorouracil adriamycin prednisolone are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Association of rash with outcomes in a randomized phase II trial evaluating cetuximab in combination with mitoxantrone plus prednisone after docetaxel for metastatic castration-resistant prostate cancer . | cetuximab mitoxantrone prednisone are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? CDM mice show decreased Homer1a and Homer1b/c mRNA expression in cortex and blood samples , while chronic treatment with imipramine and fluoxetine or acute ketamine application increases their level only in the cortex . | imipramine fluoxetine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? A retrospective analysis was conducted on the clinical data of 122 advanced NSCLC patients with pleural effusion , and among them , 61 received thoracic hyperthermic perfusion with recombinant human endostatin ( ES ) plus nedaplatin ( Endostatin group ) , while the other 61 underwent thoracic hyperthermic perfusion with cisplatin alone ( Cisplatin group ) . | endostatin nedaplatin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? In addition , stimulation of erythropoiesis with recombinant human erythropoietin , supplemental iron therapy , and improving haemostasis by aprotinin may further reduce homologous blood requirements . | erythropoietin iron aprotinin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? In the presence of heparin and cortisone and of cortisone alone there was a 4.5- and 2.3-fold reduction , respectively , in the growth of the 9L glioma . | heparin cortisone are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? It was the aim of this study to evaluate maintenance therapy with bevacizumab + capecitabine following induction with bevacizumab + capecitabine + oxaliplatin ( XELOX ) versus bevacizumab + XELOX until progression as first-line therapy in metastatic colorectal cancer ( mCRC ) . | bevacizumab capecitabine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Etoposide ( 25 mg , twice daily ) and prednisone ( 5 mg , twice daily ) were administered orally . | Etoposide prednisone are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Rosuvastatin + ezetimibe , simvastatin + ezetimibe , and atorvastatin + ezetimibe were the most cost-effective combination therapies for reducing LDL-C levels . | Rosuvastatin ezetimibe are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? This 40-week open-label extension of the 12-week double-blind Triple Therapy With Olmesartan Medoxomil , Amlodipine , and Hydrochlorothiazide in Hypertensive Patients Study ( TRINITY ) evaluated the efficacy and safety of triple-combination treatments with olmesartan medoxomil , amlodipine besylate , and hydrochlorothiazide ( OM/AML/HCTZ ) in 2112 participants with moderate to severe hypertension . | Olmesartan Amlodipine Hydrochlorothiazide are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Nithiamide and chlortetracycline + sulfamethazine + penicillin were least effective in preventing SD during the infection + medication and postmedication periods . | chlortetracycline sulfamethazine penicillin are the drug combinations. No need for context. It is a NEG combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Initial treatment with either neoadjuvant chemoradiation ( CRT ) or induction FOLFOX ( 5-Fluorouracil , leucovorin , and oxaliplatin ) chemotherapy followed by CRT is considered standard treatment for locally advanced rectal cancer . | 5-Fluorouracil leucovorin oxaliplatin are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Prior to the procedure , the child was administered a dental cocktail containing chloral hydrate , hydroxyzine , and methadone . | chloral hydrate hydroxyzine methadone are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Additive beneficial effects of fenofibrate combined with atorvastatin in the treatment of combined hyperlipidemia . | fenofibrate atorvastatin are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Bevacizumab with or without erlotinib as maintenance therapy in patients with metastatic colorectal cancer ( GERCOR DREAM ; OPTIMOX3 ): a randomised , open-label , phase 3 trial . | Bevacizumab erlotinib are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Eighteen patients with primary or recurrent ovarian cancer were treated with paclitaxel 150 or 110 mg/m2 , respectively , together with gemcitabine 800 mg/m2 and cisplatin 75 mg/m2 , 3 weekly for 6 cycles . | paclitaxel gemcitabine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The cost-minimisation analysis showed that treatment costs for a 12-week course of capecitabine ( Pounds 2132 ) and tegafur with uracil ( Pounds 3385 ) were lower than costs for the intravenous Mayo regimen ( Pounds 3593 ) and infusional regimens on the de Gramont ( Pounds 6255 ) and Modified de Gramont ( Pounds 3485 ) schedules over the same treatment period . | capecitabine tegafur uracil are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? However , the combination of clindamycin and ciprofloxacin increased mortality associated with B. anthracis Sterne infection , particularly in gamma-irradiated animals . | clindamycin ciprofloxacin are the drug combinations. No need for context. It is a NEG combination. |
drug_combination | What is the drug combination mentioned in the following sentence? We investigated the maximum tolerated dose , dose-limiting toxicities , and response rate when the selective cyclooxygenase-2 inhibitor celecoxib is added to concurrent irinotecan , cisplatin , and radiation therapy for patients with inoperable stage II-III non-small cell lung cancer ( NSCLC ) . | celecoxib irinotecan cisplatin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The combination of docetaxel and estramustine phosphate ( estramustine ) has been reported to be effective for HRPC . | docetaxel estramustine are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? A fixed-dose combination of artesunate + amodiaquine ( ASAQ ) was recently developed . | artesunate amodiaquine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? All patients have received a median of four and half cycles ( range , 1 - 10 ) of 3-week ( 60 - 75 mg/m2 ) docetaxel regimens and 5 mg prednisone twice per day . | docetaxel prednisone are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The results of this work encourage the in vivo examination of the therapeutic potential of the combination of bortezomib and rapamycin in Mantle Cell Lymphoma patients . | bortezomib rapamycin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Additive effects of combined valsartan and spironolactone on cardiac aldosterone escape in spontaneously hypertensive rats . | valsartan spironolactone are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? 54 patients without distant metastases ( T2-T3b , N0-X , M0 ) received 3 cycles of neoadjuvant chemotherapy according to the MVAC protocol ( methotrexate , vinblastine , doxorubicin and cisplatin ) after transurethral resection ( TUR ) followed by cystectomy . | methotrexate vinblastine doxorubicin cisplatin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The objective of this study was to compare cycle control , efficacy and tolerance of an oral contraceptive containing 20 microg ethinylestradiol and 150 microg desogestrel with a preparation containing 30 microg ethinylestradiol combined with 75 microg gestodene . | ethinylestradiol desogestrel are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? They were assigned to either receiving a COCP containing 20 mcg ethinyl estradiol/150 mg desogestrel for two continuous cycle or NSAID ; mefenamic acid 500 mg TDS for 5 days , 21 days apart for two cycles . | ethinyl desogestrel are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Preclinical data suggest that enzastaurin and bevacizumab may have complementary effects in inhibiting angiogenesis . | enzastaurin bevacizumab are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Trials have demonstrated decreased relapse with perioperative methotrexate , vinblastine , doxorubicin and cisplatin ( M-VAC ) chemotherapy in patients with muscle invasive bladder cancer . | methotrexate vinblastine doxorubicin cisplatin are the drug combinations. No need for context. It is a POS combination. |