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Rats were subchronically primed with nicotine , clozapine or saline . | [{'class': 'COMB', 'spans': ['nicotine', 'clozapine', 'saline'], 'is_context_needed': True}] |
The chimeric anti- EGFR monoclonal antibody cetuximab has been approved for EGFR-expressing colorectal tumors in patients who progress after irinotecan-based chemotherapy in combination with irinotecan and in squamous cell head and neck carcinomas for patients with locally advanced disease in combination with radiation therapy or after failure of platinum-based chemotherapy in recurrent or metastatic disease ( FDA ) . | [] |
New agents , such as taxane , irinotecan and oxaliplatin , combined with old agents , such as cisplatin and 5-FU , are currently under evaluation to further improve treatment outcomes . | [{'class': 'COMB', 'spans': ['taxane', 'cisplatin', '5-FU'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 3, 4], 'is_context_needed': True}, {'class': 'COMB', 'spans': [1, 3, 4], 'is_context_needed': True}] |
Taxinol , Gemcitabine ( GEM ) , Navelbine ( NVB ) , Edatrexate ( ETX ) , CPT-11 and high dose Epirubicin ( EPI HD ) are recommended as new effective drugs . | [] |
One group was given enalapril ( EN ) 50 mg/l dissolved in the drinking water ; the second received lovastatin ( L ) 15 mg/kg given daily by gavage ; the third received both agents ; the fourth was left untreated , and the final group received no puromycin and served as the control group . | [{'class': 'COMB', 'spans': ['enalapril', 'lovastatin'], 'is_context_needed': True}] |
Using the Killing-curve method , we tested the in vitro bactericidal activity of fosfomycin alone or in combination with vancomycin or teicoplanin at a concentration of 8 microg/mL , that is easily achievable in serum at standard dosing regimens , against seven methicillin-resistant Staphylococcus aureus strains , isolated from patients with well documented device-associated infections unresponsive to or relapsing after glycopeptide therapy . | [{'class': 'COMB', 'spans': ['fosfomycin', 'vancomycin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}] |
Combination therapy with mitomycin , tamoxifen , and UFT proved to be an effective postoperative chemoendocrine therapy for stage II , ER-positive breast cancer . | [{'class': 'POS', 'spans': ['mitomycin', 'tamoxifen', 'UFT'], 'is_context_needed': False}] |
The remaining 76 patients did not receive anti-thymocyte globulin but were given cyclosporine A and methotrexate or mycophenolate mofetil ( group 3 ) . | [{'class': 'COMB', 'spans': ['cyclosporine', 'methotrexate'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}] |
Propranolol significantly decreased the maximum plasma concentration ( Cmax ) and area under the plasma concentration-time curve ( AUC ) of lacidipine ( by 38 % and 42 % , respectively ) whereas lacidipine significantly increased the Cmax and AUC of propranolol ( by 35 % and 26 % , respectively ) ; neither the time to maximum plasma concentration ( tmax ) nor the terminal half-life ( t 1/2 ) were affected . | [{'class': 'COMB', 'spans': ['Propranolol', 'lacidipine'], 'is_context_needed': True}] |
The patient received chemotherapy comprising vincristine , actinomycin D , doxorubicin , cisplatin , and cyclophosphamide . | [{'class': 'COMB', 'spans': ['vincristine', 'doxorubicin', 'cyclophosphamide', 'actinomycin', 'cisplatin'], 'is_context_needed': True}] |
It was found that the increase in acoustic startle responses observed with ethanol or nicotine was attenuated by haloperidol . | [] |
The use of tacrolimus ( 88 % vs 77 % , P=.02 ) and cytolytic therapy ( 81 % vs 46 % , P < .0001 ) was likewise greater among patients who received ganciclovir prophylaxis . | [] |
Because gemcitabine has been considered a standard treatment for advanced pancreatic cancer for the past decade , several randomized trials have tested the combination of gemcitabine plus a second agent , including platinum based agents , topoisomerase inhibitors , taxanes , bevacizumab and cetuximab , as biologically " targeted " agents . | [{'class': 'COMB', 'spans': ['gemcitabine', 'bevacizumab'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [1, 3], 'is_context_needed': True}] |
Gemcitabine and recently FOLFIRINOX ( 5-flourouracil , leucovorin , oxaliplatin and irinotecan ) have provided some limited survival advantage in advanced pancreatic cancer . | [] |
No synergism was found against Pneumococci and Meningococci but also no antagonism of the lower MIC and MBC values seen with ampicillin and penicillin G. The combination of chloramphenicol with either penicillin or ampicillin constitutes a clinically successful therapeutic regimen which is now also proven by in vitro investigations . | [{'class': 'COMB', 'spans': ['ampicillin', 'penicillin'], 'is_context_needed': True}, {'class': 'POS', 'spans': [1, 4], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 2], 'is_context_needed': False}] |
Similarly , nifedipine , nitroglycerin and hydralazine should not to be considered first-line therapies in the management of hypertensive crises because these agents are associated with significant toxicities and/or adverse effects . | [] |
Bendamustine is effective both with rituximab and as a monotherapy in rituximab-refractory patients . | [{'class': 'POS', 'spans': ['Bendamustine', 'rituximab'], 'is_context_needed': False}] |
Ten micromoles of gefitinib reversed topotecan , SN-38 , and mitoxantrone resistance , and increased the intracellular topotecan accumulation in the resistant cells but not in the parental cells . | [] |
The effects of multiple combination chemotherapy with vincristine , cyclophosphamide ( Endoxan ) , methotrexate , 5-fluorouracil , adriamycin and prednisolone ( VEMFAH ) for advanced breast cancer . | [{'class': 'POS', 'spans': ['vincristine', 'cyclophosphamide', 'methotrexate', '5-fluorouracil', 'adriamycin', 'prednisolone'], 'is_context_needed': True}] |
Association of rash with outcomes in a randomized phase II trial evaluating cetuximab in combination with mitoxantrone plus prednisone after docetaxel for metastatic castration-resistant prostate cancer . | [{'class': 'NEG', 'spans': ['cetuximab', 'mitoxantrone', 'prednisone'], 'is_context_needed': True}] |
CDM mice show decreased Homer1a and Homer1b/c mRNA expression in cortex and blood samples , while chronic treatment with imipramine and fluoxetine or acute ketamine application increases their level only in the cortex . | [{'class': 'COMB', 'spans': ['imipramine', 'fluoxetine'], 'is_context_needed': True}] |
A retrospective analysis was conducted on the clinical data of 122 advanced NSCLC patients with pleural effusion , and among them , 61 received thoracic hyperthermic perfusion with recombinant human endostatin ( ES ) plus nedaplatin ( Endostatin group ) , while the other 61 underwent thoracic hyperthermic perfusion with cisplatin alone ( Cisplatin group ) . | [{'class': 'POS', 'spans': ['endostatin', 'nedaplatin'], 'is_context_needed': True}] |
In addition , stimulation of erythropoiesis with recombinant human erythropoietin , supplemental iron therapy , and improving haemostasis by aprotinin may further reduce homologous blood requirements . | [{'class': 'POS', 'spans': ['erythropoietin', 'iron', 'aprotinin'], 'is_context_needed': True}] |
In the presence of heparin and cortisone and of cortisone alone there was a 4.5- and 2.3-fold reduction , respectively , in the growth of the 9L glioma . | [{'class': 'POS', 'spans': ['heparin', 'cortisone'], 'is_context_needed': False}] |
Dibutyryl cAMP , forskolin and theophylline stimulated secretion of pancreastatin and somatostatin . | [] |
It was the aim of this study to evaluate maintenance therapy with bevacizumab + capecitabine following induction with bevacizumab + capecitabine + oxaliplatin ( XELOX ) versus bevacizumab + XELOX until progression as first-line therapy in metastatic colorectal cancer ( mCRC ) . | [{'class': 'POS', 'spans': ['bevacizumab', 'capecitabine'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3, 4], 'is_context_needed': True}] |
We chose to assess the chemopreventive effect of three different drugs : pioglitazone , lanreotide and S-trans-trans-farnesylthiosalicylic acid ( FTS ) . | [] |
Etoposide ( 25 mg , twice daily ) and prednisone ( 5 mg , twice daily ) were administered orally . | [{'class': 'POS', 'spans': ['Etoposide', 'prednisone'], 'is_context_needed': True}] |
Rosuvastatin + ezetimibe , simvastatin + ezetimibe , and atorvastatin + ezetimibe were the most cost-effective combination therapies for reducing LDL-C levels . | [{'class': 'POS', 'spans': ['Rosuvastatin', 'ezetimibe'], 'is_context_needed': False}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': False}, {'class': 'POS', 'spans': [4, 5], 'is_context_needed': False}] |
This 40-week open-label extension of the 12-week double-blind Triple Therapy With Olmesartan Medoxomil , Amlodipine , and Hydrochlorothiazide in Hypertensive Patients Study ( TRINITY ) evaluated the efficacy and safety of triple-combination treatments with olmesartan medoxomil , amlodipine besylate , and hydrochlorothiazide ( OM/AML/HCTZ ) in 2112 participants with moderate to severe hypertension . | [{'class': 'POS', 'spans': ['Olmesartan', 'Amlodipine', 'Hydrochlorothiazide'], 'is_context_needed': True}] |
Nithiamide and chlortetracycline + sulfamethazine + penicillin were least effective in preventing SD during the infection + medication and postmedication periods . | [{'class': 'NEG', 'spans': ['chlortetracycline', 'sulfamethazine', 'penicillin'], 'is_context_needed': False}] |
The largest number of strains was resistant to gentamicin , followed by erythromycin . | [] |
Behavioural impact of intraseptally released vasopressin and oxytocin in rats . | [] |
Optimized 14 day sequential therapy was non-inferior to , but better tolerated than 10 day bismuth quadruple therapy and both may be used in first-line treatment in populations with low to intermediate clarithromycin resistance . | [] |
Initial treatment with either neoadjuvant chemoradiation ( CRT ) or induction FOLFOX ( 5-Fluorouracil , leucovorin , and oxaliplatin ) chemotherapy followed by CRT is considered standard treatment for locally advanced rectal cancer . | [{'class': 'POS', 'spans': ['5-Fluorouracil', 'leucovorin', 'oxaliplatin'], 'is_context_needed': False}] |
Prior to the procedure , the child was administered a dental cocktail containing chloral hydrate , hydroxyzine , and methadone . | [{'class': 'NEG', 'spans': ['chloral hydrate', 'hydroxyzine', 'methadone'], 'is_context_needed': True}] |
We aimed to compare the effect of four TK inhibitors ( axitinib , sunitinib , vandetanib , and XL184 ) on cell proliferation , RET expression and autophosphorylation , and ERK activation in cell lines expressing a MEN2A ( MTC-TT ) , a MEN2B ( MZ-CRC-1 ) mutation , and a RET/PTC ( TPC-1 ) rearrangement . | [] |
Additive beneficial effects of fenofibrate combined with atorvastatin in the treatment of combined hyperlipidemia . | [{'class': 'POS', 'spans': ['fenofibrate', 'atorvastatin'], 'is_context_needed': False}] |
S. sciuri exhibited pronounced multiresistance , and many isolates were characterised by the carriage of a number of uncommon (multi)resistance genes ( e.g. cfr , apmA , fexA ) and decreased susceptibility towards last resort antibiotics such as linezolid and daptomycin . | [] |
The results showed that chlorhexidine ( 0.5 mM ) was more effective than benzalkonium chloride ( 1 mM ) and piperazine ( 1 mM ) . | [] |
Finally , although anidulafungin ( as an echinocandin surrogate susceptibility marker ) and amphotericin B ECVs should identify Candida and Aspergillus isolates with reduced susceptibility to these agents using the Etest , these ECVs will not categorize a fungal isolate as susceptible or resistant , as breakpoints do . | [] |
The method decision limits were determined to be 1.27 and 0.59 microg/kg for erythromycin and tylosin , respectively . | [] |
Bevacizumab with or without erlotinib as maintenance therapy in patients with metastatic colorectal cancer ( GERCOR DREAM ; OPTIMOX3 ): a randomised , open-label , phase 3 trial . | [{'class': 'POS', 'spans': ['Bevacizumab', 'erlotinib'], 'is_context_needed': True}] |
Eighteen patients with primary or recurrent ovarian cancer were treated with paclitaxel 150 or 110 mg/m2 , respectively , together with gemcitabine 800 mg/m2 and cisplatin 75 mg/m2 , 3 weekly for 6 cycles . | [{'class': 'COMB', 'spans': ['paclitaxel', 'gemcitabine'], 'is_context_needed': True}] |
After pretreatment with warfarin ( 0.2 mg/kg/day ) , low-dose rivaroxaban ( 60 mg/kg/day ) , high-dose rivaroxaban ( 120 mg/kg/day ) , or vehicle for 14 days , transient middle cerebral artery occlusion was induced for 90 min , followed by reperfusion with tPA ( 10 mg/kg/10 ml ) . | [] |
The cost-minimisation analysis showed that treatment costs for a 12-week course of capecitabine ( Pounds 2132 ) and tegafur with uracil ( Pounds 3385 ) were lower than costs for the intravenous Mayo regimen ( Pounds 3593 ) and infusional regimens on the de Gramont ( Pounds 6255 ) and Modified de Gramont ( Pounds 3485 ) schedules over the same treatment period . | [{'class': 'COMB', 'spans': ['capecitabine', 'tegafur', 'uracil'], 'is_context_needed': True}] |
However , the combination of clindamycin and ciprofloxacin increased mortality associated with B. anthracis Sterne infection , particularly in gamma-irradiated animals . | [{'class': 'NEG', 'spans': ['clindamycin', 'ciprofloxacin'], 'is_context_needed': False}] |
We investigated the maximum tolerated dose , dose-limiting toxicities , and response rate when the selective cyclooxygenase-2 inhibitor celecoxib is added to concurrent irinotecan , cisplatin , and radiation therapy for patients with inoperable stage II-III non-small cell lung cancer ( NSCLC ) . | [{'class': 'POS', 'spans': ['celecoxib', 'irinotecan', 'cisplatin'], 'is_context_needed': True}] |
The combination of docetaxel and estramustine phosphate ( estramustine ) has been reported to be effective for HRPC . | [{'class': 'POS', 'spans': ['docetaxel', 'estramustine'], 'is_context_needed': False}] |
Significant advances have been made in the last decade since the introduction of different tyrosine kinase inhibitors ( TKIs ) such as sunitinib , pazopanib , and sorafenib . | [] |
A fixed-dose combination of artesunate + amodiaquine ( ASAQ ) was recently developed . | [{'class': 'POS', 'spans': ['artesunate', 'amodiaquine'], 'is_context_needed': True}] |
All patients have received a median of four and half cycles ( range , 1 - 10 ) of 3-week ( 60 - 75 mg/m2 ) docetaxel regimens and 5 mg prednisone twice per day . | [{'class': 'POS', 'spans': ['docetaxel', 'prednisone'], 'is_context_needed': True}] |
Combination therapy with other agents including anticoagulants , antihypertensive , anti-inflammatory , oral hypoglycemic and antifungal agents as well as beta-blockers , H2 blockers , cyclosporine and digoxin has been also reviewed . | [] |
Comparative study of tranexamic acid and norethisterone in the treatment of ovulatory menorrhagia . | [] |
The results of this work encourage the in vivo examination of the therapeutic potential of the combination of bortezomib and rapamycin in Mantle Cell Lymphoma patients . | [{'class': 'POS', 'spans': ['bortezomib', 'rapamycin'], 'is_context_needed': True}] |
Additive effects of combined valsartan and spironolactone on cardiac aldosterone escape in spontaneously hypertensive rats . | [{'class': 'POS', 'spans': ['valsartan', 'spironolactone'], 'is_context_needed': False}] |
54 patients without distant metastases ( T2-T3b , N0-X , M0 ) received 3 cycles of neoadjuvant chemotherapy according to the MVAC protocol ( methotrexate , vinblastine , doxorubicin and cisplatin ) after transurethral resection ( TUR ) followed by cystectomy . | [{'class': 'POS', 'spans': ['methotrexate', 'vinblastine', 'doxorubicin', 'cisplatin'], 'is_context_needed': True}] |
The objective of this study was to compare cycle control , efficacy and tolerance of an oral contraceptive containing 20 microg ethinylestradiol and 150 microg desogestrel with a preparation containing 30 microg ethinylestradiol combined with 75 microg gestodene . | [{'class': 'POS', 'spans': ['ethinylestradiol', 'desogestrel'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': True}] |
They were assigned to either receiving a COCP containing 20 mcg ethinyl estradiol/150 mg desogestrel for two continuous cycle or NSAID ; mefenamic acid 500 mg TDS for 5 days , 21 days apart for two cycles . | [{'class': 'POS', 'spans': ['ethinyl', 'desogestrel'], 'is_context_needed': True}] |
Preclinical data suggest that enzastaurin and bevacizumab may have complementary effects in inhibiting angiogenesis . | [{'class': 'POS', 'spans': ['enzastaurin', 'bevacizumab'], 'is_context_needed': False}] |
The PASI-75 , -90 and -100 were the highest in secukinumab ( 91.3 % , 82.6 % , 41.3 % , respectively ) , followed by ustekinumab ( 79.6 % , 44.9 % , 16.3 % ) , adalimumab ( 64.3 % , 28.6 % , 7.1 % ) and etanercept ( 50.0 % , 30.0 % , 0 % ) . | [] |
Trials have demonstrated decreased relapse with perioperative methotrexate , vinblastine , doxorubicin and cisplatin ( M-VAC ) chemotherapy in patients with muscle invasive bladder cancer . | [{'class': 'POS', 'spans': ['methotrexate', 'vinblastine', 'doxorubicin', 'cisplatin'], 'is_context_needed': False}] |
m2 on day 1 , oxaliplatin 85 mg/m² day 1 and capecitabine twice-daily dose of 625 mg/ m2 , p.o . for 2 weeks ) every 3 | [{'class': 'POS', 'spans': ['oxaliplatin', 'capecitabine'], 'is_context_needed': True}] |
The objective of this analysis was to assess the cost-effectiveness of risedronate compared to generic alendronate in Germany applying the REAL effectiveness data . | [] |
However , two phase III trials demonstrated that incorporation of oxaliplatin to capecitabine with RT did not improve early outcomes and , by contrast , increased toxicity . | [{'class': 'NEG', 'spans': ['oxaliplatin', 'capecitabine'], 'is_context_needed': False}] |
The addition of everolimus to bicalutamide treatment of resistant tumours significantly reduced tumour growth rates and tumour volumes . | [{'class': 'POS', 'spans': ['everolimus', 'bicalutamide'], 'is_context_needed': False}] |
Ropivacaine and bupivacaine were the common drugs used for RA , which were independent of RA utilization . | [] |
In 13 patients treated with equivalent doses of rotigotine switched from other DAs ( pramipexole , ropinirole , and cabergoline ) , ESS did not increase after treatment ( 10.0 ± 4.6 before and 8.6 ± 4.5 after treatment ) and decreased without worsening of CGI-I in 54 % patients . | [] |
To assess plasma steady-state pharmacokinetics ( PK ) of rifampicin , isoniazid , saquinavir and ritonavir in HIV and tuberculosis ( TB ) co-infected patients , and investigate potential interactions between TB drugs and protease inhibitors ( PIs ) . | [{'class': 'COMB', 'spans': ['isoniazid', 'saquinavir', 'ritonavir', 'rifampicin'], 'is_context_needed': True}] |
We randomly assigned 808 patients with HER2-positive metastatic breast cancer to receive placebo plus trastuzumab plus docetaxel ( control group ) or pertuzumab plus trastuzumab plus docetaxel ( pertuzumab group ) as first-line treatment until the time of disease progression or the development of toxic effects that could not be effectively managed . | [{'class': 'POS', 'spans': ['pertuzumab', 'trastuzumab', 'docetaxel'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1], 'is_context_needed': True}] |
Toxicological studies revealed that the oral LD50 for thiabendazole in mice was 2200 mg/kg , and when combined with 140 mg/kg of aspirin , the LD50 was reduced to 900 mg/kg . | [{'class': 'NEG', 'spans': ['thiabendazole', 'aspirin'], 'is_context_needed': False}] |
Azacitidine and enasidenib are two therapies available for treatment of acute myelogenous leukemia ( AML ) , and the mechanisms of action of these drugs involve alteration of aberrant DNA methylation . | [{'class': 'COMB', 'spans': ['Azacitidine', 'enasidenib'], 'is_context_needed': True}] |
Good , moderate and mild pain relief were noted in 19 ( 41 % ) , six ( 13 % ) and seven ( 15 % ) patients on lamotrigine and 13 ( 28 % ) , five ( 11 % ) and 15 ( 33 % ) patients on amitriptyline , respectively , by patient 's global assessment of efficacy and safety . | [{'class': 'NEG', 'spans': ['lamotrigine', 'amitriptyline'], 'is_context_needed': True}] |
The majority of the evidence comes from studies of bevacizumab and triamcinolone used as primary therapy for DMO . | [{'class': 'COMB', 'spans': ['bevacizumab', 'triamcinolone'], 'is_context_needed': True}] |
Doxorubicin and ifosfamide are currently the two main drugs for the treatment of soft tissue sarcomas in adults . | [{'class': 'POS', 'spans': ['Doxorubicin', 'ifosfamide'], 'is_context_needed': True}] |
The skin and oral mucous membrane lesions recurred after effective treatments with methylprednisolone pulse therapy and combination therapy with prednisolone and cyclosporine . | [{'class': 'COMB', 'spans': ['prednisolone', 'cyclosporine'], 'is_context_needed': True}] |
Incorporation of colistin significantly accelerated the release of ciprofloxacin from the DMPG anionic liposomes . | [{'class': 'POS', 'spans': ['colistin', 'ciprofloxacin'], 'is_context_needed': False}] |
MAB using flutamide as second-line hormonal therapy can give a comparatively favourable PSA response with no severe side-effects ; therefore , this therapy may be suitable for patients with HRPC after primary MAB using bicalutamide has failed , particularly in those with no bone metastases or whose disease has progressed for > 1 year after first-line therapy . | [] |
Phase I study of decitabine in combination with vorinostat in patients with advanced solid tumors and non-Hodgkin 's lymphomas . | [{'class': 'POS', 'spans': ['decitabine', 'vorinostat'], 'is_context_needed': True}] |
Epirubicin ( 35 mg/m(2 ) ) and cyclophosphamide ( 400 mg/m(2 ) ) were administered from day 2 to day 4 , every 4 weeks . | [{'class': 'POS', 'spans': ['Epirubicin', 'cyclophosphamide'], 'is_context_needed': True}] |
Our patient could be weaned from LVAD probably due to the combination management strategy employing mitral valvuloplasty , use of cardiac resynchronization therapy , and taking carvedilol with spironolactone . | [{'class': 'POS', 'spans': ['carvedilol', 'spironolactone'], 'is_context_needed': False}] |
Serum hydroxyzine and cetirizine concentrations were above the limit of quantitation ( 0.1 ng/ml ) of the assay | [{'class': 'NEG', 'spans': ['hydroxyzine', 'cetirizine'], 'is_context_needed': True}] |
Although well tolerated , the efficacy of everolimus and vinorelbine combination therapy was not superior to vinorelbine monotherapy . | [{'class': 'NEG', 'spans': ['everolimus', 'vinorelbine'], 'is_context_needed': False}] |
In addition , our results suggested that adalimumab , tocilizumab , rituximab and glucocorticoids may also have beneficial effects in restoring normal transcriptome , but not chloroquine , hydroxychloroquine or interferons . | [] |
In addition , biochemical examinations revealed that docetaxel could induce phosphorylation of both bcl-2 and c-raf-1 , but these changes were inhibited when tumor cells were pretreated or simultaneously treated with doxorubicin . | [{'class': 'NEG', 'spans': ['docetaxel', 'doxorubicin'], 'is_context_needed': False}] |
Enhancement of radiation-induced downstaging of rectal cancer by fluorouracil and high-dose leucovorin chemotherapy . | [{'class': 'POS', 'spans': ['fluorouracil', 'leucovorin'], 'is_context_needed': False}] |
Final analysis of a phase II study of nivolumab in combination with ipilimumab for unresectable chemotherapy-naive advanced melanoma . | [{'class': 'NEG', 'spans': ['nivolumab', 'ipilimumab'], 'is_context_needed': True}] |
In some relatively developed regions in China , infliximab and rituximab may be a favorable cost-effective alternative for moderate to severe RA . | [{'class': 'POS', 'spans': ['infliximab', 'rituximab'], 'is_context_needed': False}] |
Topiramate CR treatment produced significant weight loss and meaningful improvements in A1C and blood pressure in obese patients with type 2 diabetes treated with diet and exercise or in combination with metformin . | [{'class': 'POS', 'spans': ['Topiramate', 'metformin'], 'is_context_needed': False}] |
To compare efficacy and toxicity of bolus application of chemotherapy protocol , oxaliplatin , fluorouracil ( bolus ) , leucovorin ( folfox ) between two groups of patients in the therapy of metastatic colorectal carcinoma ( mCRC ) . | [{'class': 'COMB', 'spans': ['oxaliplatin', 'fluorouracil', 'leucovorin'], 'is_context_needed': True}] |
Verapamil and quinine were added in patients with tumors failing to respond or progressing on CVAD alone . | [{'class': 'POS', 'spans': ['Verapamil', 'quinine'], 'is_context_needed': True}] |
However , dipyridamole had no effect on both the influx and efflux of epirubicin in doxorubicin-sensitive cells . | [{'class': 'NEG', 'spans': ['dipyridamole', 'epirubicin'], 'is_context_needed': True}] |
This study aims to evaluate the potential role of combination therapy with docetaxel , flavopiridol , or 5-FU in modulating chemosensitivity and better understand how they might be used clinically . | [{'class': 'POS', 'spans': ['docetaxel', 'flavopiridol'], 'is_context_needed': True}] |
Dipyridamole or dipyridamole and acetylsalicyclic acid were used in 22 pregnancies . | [{'class': 'COMB', 'spans': ['dipyridamole', 'acetylsalicyclic acid'], 'is_context_needed': True}] |
Bevacizumab and trastuzumab are efficacious for treatment of advanced or HER2-positive metastatic breast cancer ; however , few data exist for this regimen in inflammatory breast cancer . | [{'class': 'COMB', 'spans': ['Bevacizumab', 'trastuzumab'], 'is_context_needed': True}] |
The frequency of their resistance to penicillin and ampicillin was 76.8 % ( 159/207 ) , followed by erythromycin ( 56 % , 116/207 ) , trimethoprim-sulfamethoxazole ( 28.5 % , 59/207 ) , chloramphenicol ( 24.2 % , 50/207 ) , kanamycin ( 19.8 % , 41/207 ) , and doxycycline ( 1.4 % , 3/207 ) . | [] |
Rats were distributed into three groups ( n = 5 ) according to the drug studied namely , 50 % enantiomeric excess bupivacaine mixture ( 5 μg/mL ) ; pancuronium ( 2 μg/mL ) ; 50 % enantiomeric excess bupivacaine mixture + pancuronium . | [{'class': 'COMB', 'spans': ['bupivacaine', 'pancuronium'], 'is_context_needed': True}] |
Blood was sampled immediately prior to premedication ( temazepam ) , after induction of anaesthesia ( fentanyl and thiopentone ) and at 10-minute intervals until the end of the procedure ( N2O maintenance , vecuronium relaxation ) . | [{'class': 'COMB', 'spans': ['temazepam', 'fentanyl', 'thiopentone', 'vecuronium'], 'is_context_needed': True}] |
This study was performed to compare the efficacy of peritonsillar infiltration of bupivacaine , tramadol and combination of bupivacaine-tramadol in post-tonsillectomy pain . | [] |
The planned concomitant treatment in group B was : bleomycin 5 units twice a week i.m . , total dose 70 units , mitomycin C 15 mg/m2 i.v . after delivery of 10 Gy , and 10 mg/m2 i.v . on the last day of radiotherapy . | [{'class': 'POS', 'spans': ['bleomycin', 'mitomycin'], 'is_context_needed': True}] |