question
stringlengths 47
584
| answer
stringlengths 2
337
|
|---|---|
Ra ( rate of production ) was measured during infusion of variable doses of epinephrine with or without variable doses of propranolol , a competitive beta-adrenergic antagonist to isolate the alpha-adrenergic agonist effects . | [{'class': 'COMB', 'spans': ['epinephrine', 'propranolol'], 'is_context_needed': True}] |
The ranking order of the response rate was LD ( best ) , doxorubicin , epirubicin , ED , and DD ( worst ) . | [] |
Systemic treatment with physostigmine , an inhibitor of acetylcholinesterase , modestly reduced the acquisition and rate of heroin self-administration , and this suppression of heroin intake was reversed by pretreatment with scopolamine but not by mecamylamine . | [] |
First-line lenvatinib , which was shown to be noninferior to sorafenib , excluded patients with main portal trunk invasion . | [] |
The OAK study evaluated the efficacy and safety of atezolizumab versus docetaxel as second-line or third-line treatment for stage IIIb/IV non-small cell lung cancer . | [] |
In conclusion , combined treatment with 0.375 IU of bleomycin and 4 mg of triamcinolone acetonide to 1 cm2 was considered to be an acceptable procedure for the treatment of keloids . | [] |
A 29-year-old man with juvenile myoclonic epilepsy and medically refractory GTCS on a combination of levetiracetam and topiramate was started on lacosamide adjunctive therapy with the plan to replace topiramate . | [{'class': 'COMB', 'spans': ['levetiracetam', 'topiramate'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [0, 2], 'is_context_needed': True}] |
[ A randomized controlled trial of immunochemotherapy using carmofur ( HCFU ) , mitomycin C and immunopotentiators in advanced gastric cancer following noncurative resection and nonresection ] . | [{'class': 'POS', 'spans': ['carmofur', 'mitomycin'], 'is_context_needed': True}] |
We thus undertook an extensive longitudinal immunologic study , including phenotypic , transcriptomic , and functional analyses , on 44 first-line and 27 relapsed/refractory patients enrolled in the GALEN trial ( Obinutuzumab Combined With Lenalidomide for Relapsed or Refractory Follicular B-Cell Lymphoma ) to test the efficacy of lenalidomide and obinutuzumab combination in patients with FL . | [{'class': 'COMB', 'spans': ['Obinutuzumab', 'Lenalidomide'], 'is_context_needed': True}] |
Blockade of beta-receptors by the nonselective beta-blocking agent propranolol did not modify the brachial artery diameter , whereas pindolol increased this parameter for the same degree of blood pressure reduction . | [] |
Nab-paclitaxel has demonstrated improved PFS and tolerability compared with standard cremophor-solubilized paclitaxel ; based on this , we examined the efficacy and safety of combining weekly nab-paclitaxel with carboplatin and bevacizumab in TNMBC . | [{'class': 'POS', 'spans': ['carboplatin', 'bevacizumab', 'nab-paclitaxel'], 'is_context_needed': True}] |
Acute renal failure ( ARF ) occurred concomitantly with the administration of gentamicin in combination with clindamycin in three patients in whom no other known predisposing cause of ARF could be demonstrated . | [{'class': 'NEG', 'spans': ['gentamicin', 'clindamycin'], 'is_context_needed': False}] |
However , nicotinic acid , nicotinamide , and pyridoxamine are not able to reverse the effect of isoniazid . | [] |
To explore the role of augmenting neutrophil function in B-cell lymphoma , we conducted a phase II study evaluating the safety and clinical efficacy of pegfilgrastim and rituximab in low-grade CD20 | [{'class': 'POS', 'spans': ['pegfilgrastim', 'rituximab'], 'is_context_needed': True}] |
The aim of this paper is to compare intravitreous aflibercept versus dexamethasone implant followed by aflibercept ( sequential treatment group ) in patients with diabetic macular edema ( DME ) . | [{'class': 'POS', 'spans': ['dexamethasone', 'aflibercept'], 'is_context_needed': True}] |
Patients with advanced solid tumors received standard doses of paclitaxel and carboplatin on day 1 followed by either 0.1 mg/Kg or 0.2 mg/Kg CP-870,893 on day 3 ( Schedule A ) or day 8 ( Schedule B ) , repeated every 21 d. | [{'class': 'COMB', 'spans': ['paclitaxel', 'carboplatin', 'CP-870,893'], 'is_context_needed': True}] |
Thirty-two patients with advanced breast carcinoma were randomized to receive increasing doses of paclitaxel ( 45 , 65 , 80 , 90 and 100 mg/m2 ) or docetaxel ( 30 , 35 , 40 , 45 and 50 mg/m2 ) together with the CMF agents at the same dose as that used in the conventional regimen . | [] |
In a 52-week , open-label , multicenter , extension study , HDL-C , TG , and LDL-C levels continued to improve , or were maintained , during combination therapy with once-daily fenofibric acid 135 mg plus a moderate-dose statin ( atorvastatin 40 mg , rosuvastatin 20 mg , or simvastatin 40 mg ) . | [{'class': 'POS', 'spans': ['fenofibric', 'atorvastatin'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 3], 'is_context_needed': True}] |
To compare the safety and efficacy of 2 doses of lamivudine given in combination with zidovudine with continued zidovudine monotherapy . | [{'class': 'POS', 'spans': ['lamivudine', 'zidovudine'], 'is_context_needed': True}] |
Bradykinin enhanced the effect of carbachol by about 10 - 15 % . | [{'class': 'POS', 'spans': ['Bradykinin', 'carbachol'], 'is_context_needed': False}] |
Here , we report that combinatorial treatment using EGFRis , such as gefitinib or erlotinib , with PI3K/AKT pathway inhibitors ( PI3K/AKTis ) demonstrated a synergistic , anti-proliferative effect in cell lines of the basal-like ( BL ) subtype , a subtype of TNBC . | [{'class': 'POS', 'spans': ['gefitinib', 'PI3K/AKTis'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 2], 'is_context_needed': False}] |
Patients received gemcitabine 1000 mg/m² intravenously on days 1 and 8 , capecitabine 1300 mg/m² oral daily from day 1 to 14 , and dovitinib oral daily 5 days on and 2 days off , every 21-day cycle . | [{'class': 'POS', 'spans': ['gemcitabine', 'capecitabine', 'dovitinib'], 'is_context_needed': False}] |
A reduced dose of oxaliplatin 105 mg/m(2 ) on day 1 with doxorubicin at 20 mg/m(2)/dose on days 1 - 3 was well tolerated . | [{'class': 'POS', 'spans': ['oxaliplatin', 'doxorubicin'], 'is_context_needed': True}] |
In terms of recurrent disease , two positive phase III trials revealed that trebananib and cediranib are effective anti-angiogenic agents for this indication . | [] |
A total of 80 patients were randomized , including 44 to the combination group ( tamsulosin 0.4 mg and tolterodine early release 4 mg ) and 36 to the monotherapy group ( tamsulosin 0.4 mg and placebo ) . | [{'class': 'NEG', 'spans': ['tamsulosin', 'tolterodine'], 'is_context_needed': True}] |
However , thiostrepton , dexamethasone , 2-methoxyestradiol , δ-tocotrienol , quercetin , and quinine sulphate were effective in pancreatic , prostate , breast , lungs , melanoma , Β-lymphocytes , and T-cells ( Jurkat : 40 % to 95 % ) compared to respective controls . | [] |
Of them , 47 patients started with docetaxel at cycle one due to reaction to paclitaxel ( n=32 ) , fear of NT ( n=4 ) , and other reasons ( n=11 ) , whereas 59 patients switched to docetaxel during cycle 2 - 6 due to NT ( n=32 ) , reaction to paclitaxel ( n=19 ) , and other reasons ( n=8 ) . | [] |
Treatment of rapidly progressive glomerulonephritis by extracorporeal immunoadsorption , prednisolone and cyclophosphamide . | [{'class': 'COMB', 'spans': ['prednisolone', 'cyclophosphamide'], 'is_context_needed': True}] |
[ Doxifluridine , medroxyprogesterone acetate and cyclophosphamide ( DMpC ) combination therapy is effective against recurrent triple negative breast cancer -- a case report ] . | [{'class': 'POS', 'spans': ['Doxifluridine', 'medroxyprogesterone', 'cyclophosphamide'], 'is_context_needed': True}] |
Superposition predicted that oral dosing of 1800-mg valganciclovir two times daily would fail to produce and maintain effective plasma concentrations of ganciclovir . | [] |
The levels of 3 NF-kappaB transcription factors , the activating inhibitors of NF-kappaB ( IkappaB ) kinases , and the NF-kappaB target matrix metalloproteinase 9 ( MMP9 ) were assessed by immunohistochemistry in specimens of ovarian cancer that were obtained at diagnosis from a cohort of 33 patients who subsequently received combined paclitaxel , cisplatin , and cyclophosphamide . | [{'class': 'COMB', 'spans': ['paclitaxel', 'cyclophosphamide', 'cisplatin'], 'is_context_needed': True}] |
The clonidine DV suppression was reliably reversed by yohimbine ( 1.75 micrograms ) , but by none of the other adrenoceptor antagonists or naloxone . | [] |
There was heterogeneity in tumour responsiveness to sunitinib or sorafenib according to CAIX status ; the mean shrinkage was -17 % vs -25 % for sunitinib-treated patients with high vs low tumour CAIX expression , compared to -13 % vs + 9 % for sorafenib-treated patients ( P interaction , 0.05 ) . | [] |
Randomized Phase II Trial of Seribantumab in Combination with Erlotinib in Patients with EGFR Wild-Type Non-Small Cell Lung Cancer . | [{'class': 'NEG', 'spans': ['Seribantumab', 'Erlotinib'], 'is_context_needed': True}] |
Trabectedin in combination with pegylated liposomal doxorubicin ( PLD ) has been fully available privately in the UK since 2009 for treating patients with ROC . | [{'class': 'POS', 'spans': ['Trabectedin', 'doxorubicin'], 'is_context_needed': True}] |
More interestingly , lumefantrine tolerance is associated with an increase in chloroquine susceptibility , raising the possibility of re-introducing chloroquine . | [] |
Estramustine has been shown to potentiate the antimicrotubule effects of vinblastine . | [{'class': 'COMB', 'spans': ['Estramustine', 'vinblastine'], 'is_context_needed': True}] |
Cohort 7 ( gemcitabine 600 mg/m/wk and carboplatin 2 AUC ) showed 4 dose limiting toxicities : 2 grade 3 esophagitis ; one grade 3 febrile neutropenia ; and one grade 4 neutropenia . | [{'class': 'COMB', 'spans': ['gemcitabine', 'carboplatin'], 'is_context_needed': True}] |
Treatment with IFN-α plus bevacizumab or standard targeted therapy ( sunitinib ) may lead to similar one-year overall mortality ( RR 0.37 , 95 % CI 0.13 to 1.08 ; 1 study ; 83 participants ; low-quality evidence ) and AEs of grade 3 or greater ( RR 1.18 , 95 % CI 0.85 to 1.62 ; 1 study ; 82 participants ; low-quality evidence ) . | [{'class': 'COMB', 'spans': ['bevacizumab', 'IFN-α'], 'is_context_needed': True}] |
In vitro , ETV4 depletion inhibited cell survival but did not influence sensitivity to MEKi selumetinib or trametinib . | [] |
Our study aimed to analyze the influence of sorafenib and sunitinib on the frequency of Treg in patients with metastatic RCC ( mRCC ) . | [] |
Naloxone ( 5 x 10(-7 ) mol/kg iv ) and atropine ( 0.1 mg/kg iv ) induced isolated orad contractions . | [] |
FACT-P change from baseline over time was better for abiraterone than for enzalutamide in the ≥75-yr model ( p=0.003 ) , with no difference in the < 75-yr model ( p>0.9 ) . | [] |
The possibility that verapamil might increase the sensibility of colorectal carcinomas to doxorubicin was studied in 24 patients without previous cytotoxic chemotherapy . | [{'class': 'COMB', 'spans': ['verapamil', 'doxorubicin'], 'is_context_needed': True}] |
Twenty-six patients presenting with advanced breast cancer with a taxane- and vinorelbine-free line of chemotherapy were included and treated with vinorelbine ( 20 mg/m2 on D1 , D15 ) , followed by paclitaxel ( 175 mg/m2 on D1 ) , every 3 weeks . | [{'class': 'POS', 'spans': ['vinorelbine', 'paclitaxel'], 'is_context_needed': True}] |
Although monotherapy with cytotoxic agents , including docetaxel and pemetrexed , is recommended for patients with previously treated advanced non-small cell lung cancer ( NSCLC ) , its outcomes are unsatisfactory . | [] |
Although congestive heart failure has been reported with the combination of a beta blocker and either verapamil or nifedipine , it has not previously been reported for combination therapy that includes diltiazem . | [] |
Relationships between heart rate , exercise tolerance and cardiac output in atrial fibrillation : the effects of treatment with digoxin , verapamil and diltiazem . | [{'class': 'COMB', 'spans': ['digoxin', 'verapamil', 'diltiazem'], 'is_context_needed': True}] |
Oxaliplatin , which is effective for colorectal cancer ( CRC ) in combination with 5-fluorouracil ( 5-FU ) and leucovorin ( LV ) , is widely used for metastatic CRC . | [{'class': 'POS', 'spans': ['Oxaliplatin', 'leucovorin', '5-fluorouracil'], 'is_context_needed': True}] |
The cytotoxicity of sequential combinations of a taxoid [ paclitaxel ( TAX ) or docetaxel ( TXT ) ] with a vinca alkaloid [ vinorelbine ( NVB ) ] was compared in differentiated and undifferentiated HT29-D4 cells . | [{'class': 'COMB', 'spans': ['paclitaxel', 'vinorelbine'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [1, 2], 'is_context_needed': True}] |
Time to first deterioration was delayed with nivolumab + ipilimumab versus chemotherapy across LCSS and EQ-5D summary measures . | [{'class': 'POS', 'spans': ['nivolumab', 'ipilimumab'], 'is_context_needed': False}] |
In the present study , we investigated the effect atorvastatin , celecoxib and tipifarnib in combination on proliferation and apoptosis in Panc-1 sphere-forming cells . | [{'class': 'POS', 'spans': ['atorvastatin', 'celecoxib', 'tipifarnib'], 'is_context_needed': True}] |
As SD , donepezil , galantamine , rivastigmine , and memantine are now usable . | [] |
Raloxifene is a selective estrogen receptor modulator which is structurally similar to tamoxifen . | [] |
Recipients received the dual endothelin-1 ( ET-1 ) receptor blocker , bosentan ( 100 mg/kg ) , the angiotensin-converting enzyme ( ACE ) inhibitor , ramipril ( 5 mg/kg ) , bosentan plus ramipril ( doses as just noted ) or vehicle . | [{'class': 'POS', 'spans': ['bosentan', 'ramipril'], 'is_context_needed': True}] |
After surgery , she received a sequential chemotherapy , ie , intraabdominal injection of carboplatin ( CBDCA 300 mg/m2 ) and div administration of paclitaxel ( PTX 180 mg/m2 ) as a standard regimen for advanced ovarian cancer . | [{'class': 'POS', 'spans': ['carboplatin', 'paclitaxel'], 'is_context_needed': True}] |
They are now sufficiently detailed to have been of use in the development of new drug compounds like ranolazine and ivabradine . | [] |
Based on clinical knowledge , we re-prioritized 30 potentially repurposable drugs against COVID-19 ( including pseudoephedrine , andrographolide , chloroquine , abacavir , and thalidomide ) . | [] |
To study the release of free endotoxin from Escherichia coli exposed to varying concentrations of the penicillin-binding protein ( PBP ) 3-specific beta-lactam antibiotic cefuroxime , the aminoglycoside tobramycin , and a combination of the two , and to test the relationship between bacterial killing rate and endotoxin release . | [{'class': 'POS', 'spans': ['cefuroxime', 'tobramycin'], 'is_context_needed': True}] |
As CDK7 inhibitors are currently under clinical evaluation in patients , our data suggest the addition of the TKI ponatinib or lapatinib in CDK7 inhibitor clinical trials in patients . | [{'class': 'POS', 'spans': ['lapatinib', 'CDK7 inhibitor'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}] |
An effective treatment for operable breast cancer , NCT with epirubicin plus paclitaxel results in significant downstaging or eliminating of primary tumors in breast cancer , thus expanding the indication of breast conservation therapy . | [{'class': 'POS', 'spans': ['epirubicin', 'paclitaxel'], 'is_context_needed': False}] |
Carboplatin and etoposide for recurrent malignant glioma following surgical and radiotherapy failure : A clinical study conducted at the Northern Israel Oncology Center . | [{'class': 'NEG', 'spans': ['Carboplatin', 'etoposide'], 'is_context_needed': True}] |
ABC transporter inhibition plus dexamethasone enhances the efficacy of CED dasatinib , resulting in enhanced tumor cellular apoptosis and improved survival in H3.3K27 M mutant DIPG . | [{'class': 'POS', 'spans': ['dexamethasone', 'dasatinib'], 'is_context_needed': False}] |
Those who received prednisone alone could have mitoxantrone added after 6 weeks if there was no improvement in pain . | [{'class': 'POS', 'spans': ['prednisone', 'mitoxantrone'], 'is_context_needed': True}] |
Results of a prospective phase 2 study combining imatinib mesylate and cytarabine for the treatment of Philadelphia-positive patients with chronic myelogenous leukemia in chronic phase . | [{'class': 'POS', 'spans': ['imatinib', 'cytarabine'], 'is_context_needed': True}] |
Patient-reported outcomes of patients with advanced biliary tract cancers receiving gemcitabine plus capecitabine : a multicenter , phase II trial of the Swiss Group for Clinical Cancer Research . | [{'class': 'POS', 'spans': ['gemcitabine', 'capecitabine'], 'is_context_needed': True}] |
as neoadjuvant chemotherapy , and two cycles of doxorubicin/cisplatin and ifosfamide , and two cycles of high-dose methotrexate ( 10 - 12 g/m(2 ) ) were given post-operatively . | [{'class': 'POS', 'spans': ['doxorubicin/cisplatin', 'ifosfamide', 'methotrexate'], 'is_context_needed': True}] |
Reported is a case of a 58-year-old female treated in the past with cytostatics and rituximab for follicular lymphoma , in whom HBV infection was detected during a follow-up of the contacts of her partner diagnosed with acute viral hepatitis B. At the beginning , the patient had a very high serum level of HBV DNA ( 4.3 × 108 IU/mL ) and therefore she was treated with combined antiviral therapy ( lamivudine and tenofovir ) . | [{'class': 'POS', 'spans': ['lamivudine', 'tenofovir'], 'is_context_needed': True}] |
Patients with wild-type KRAS exon 2 mCRC previously treated with fluorouracil- , oxaliplatin- and irinotecan-based chemotherapies were randomised ( 1:1 ) to either panitumumab plus irinotecan ( panitumumab arm ) or cetuximab plus irinotecan ( cetuximab arm ) . | [{'class': 'COMB', 'spans': ['panitumumab', 'irinotecan'], 'is_context_needed': True}, {'class': 'POS', 'spans': [6, 7], 'is_context_needed': True}] |
Epirubicin , oxaliplatin , and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer ( REAL3 ): | [{'class': 'POS', 'spans': ['Epirubicin', 'oxaliplatin', 'capecitabine'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [0, 1, 2, 3], 'is_context_needed': True}] |
In 2005 , after a significant disease-free survival benefit was reported for letrozole as compared with tamoxifen , a protocol amendment facilitated the crossover to letrozole of patients who were still receiving tamoxifen alone ; Cox models and Kaplan-Meier estimates with inverse probability of censoring weighting ( IPCW ) are used to account for selective crossover to letrozole of patients ( n=619 ) in the tamoxifen arm . | [{'class': 'NEG', 'spans': ['letrozole', 'tamoxifen'], 'is_context_needed': True}] |
CEA response is associated with tumor response and survival in patients with KRAS exon 2 wild-type and extended RAS wild-type metastatic colorectal cancer receiving first-line FOLFIRI plus cetuximab or bevacizumab ( FIRE-3 trial ) . | [{'class': 'POS', 'spans': ['FOLFIRI', 'cetuximab'], 'is_context_needed': True}] |
The Tamoxifen Exemestane Adjuvant Multinational ( TEAM ) phase 3 trial was conducted in hospitals in nine countries . | [{'class': 'COMB', 'spans': ['Tamoxifen', 'Exemestane'], 'is_context_needed': True}] |
Patients used 2.16 ( range 0.0 - 6.3 ) formoterol and 2.34 ( range 0.1 - 7.5 ) terbutaline relief inhalations x day(-1 ) . | [{'class': 'COMB', 'spans': ['formoterol', 'terbutaline'], 'is_context_needed': True}] |
Preoperative chemotherapy with FLOT ( 5-FU , leucovorin , oxaliplatin and docetaxel ) without radiation therapy is the standard treatment in the West . | [{'class': 'POS', 'spans': ['5-FU', 'leucovorin', 'oxaliplatin', 'docetaxel'], 'is_context_needed': False}] |
The third-generation aromatase inhibitors ( AIs ) , including anastrozole , exemestane and letrozole , have demonstrated improved efficacy versus tamoxifen for the adjuvant endocrine treatment of postmenopausal patients with hormone receptor-positive breast cancer . | [] |
Digoxin sensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine via inhibiting Nrf2 signaling pathway . | [{'class': 'POS', 'spans': ['Digoxin', 'gemcitabine'], 'is_context_needed': False}] |
Tumor suppression was further enhanced when rapamycin was combined with 5-fluorouracil and/or oxaliplatin . | [{'class': 'POS', 'spans': ['rapamycin', '5-fluorouracil', 'oxaliplatin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}] |
These structural motifs represent typical azoles , such as econazole , fluconazole , and metyrapone . | [] |
The present systematic review and network meta-analysis was performed to conduct indirect comparisons on efficacy and safety profile among ICIs , including atezolizumab , durvalumab , pembrolizumab , and nivolumab as first-line treatment in patients with ES-SCLC . | [] |
Metformin inhibits obesity but has no effect in reducing myocardial hypertrophy caused by Rosiglitazone . | [{'class': 'NEG', 'spans': ['Metformin', 'Rosiglitazone'], 'is_context_needed': True}] |
The primary endpoint of this study was to determine the maximal tolerated dose of the combination of dose-escalating curcumin and standard dose of docetaxel chemotherapy in advanced and metastatic breast cancer patients . | [{'class': 'POS', 'spans': ['curcumin', 'docetaxel'], 'is_context_needed': False}] |
The subjects were then randomly assigned to treatment with either propranolol or metoprolol and repeated the exercise protocol after 1 week of treatment . | [] |
This case highlights the potential efficacy of combining nivolumab and regorafenib in the treatment of SBAs . | [{'class': 'POS', 'spans': ['nivolumab', 'regorafenib'], 'is_context_needed': False}] |
Of the substances tested for inhibition of 11beta-HSD-I and -II , chenodeoxycholic acid was the only one that selectively inhibited 11beta-HSD-I ( IC(50 ) for reduction : 2.8x10(-6)mol/l , IC(50 ) for oxidation : 4.4x10(-6)mol/l ) , whereas ketoconazole preferentially inhibited oxidation and reduction reactions catalyzed by 11beta-HSD-II . | [] |
Anti-tumor effects of etoposide ( VP-16 ) , vincristine and mitomycin C were evaluated with four human neuroblastoma xenograft , according to Battelle Columbus Laboratories protocol . | [] |
Biliary bile acids were mainly amidates of cholic acid and chenodeoxycholic acid , with the former predominating . | [] |
Cutaneous T-cell lymphoma-like drug eruption in an HIV-positive patient taking vancomycin and rifampin . | [{'class': 'NEG', 'spans': ['vancomycin', 'rifampin'], 'is_context_needed': False}] |
Our findings suggest that roflumilast reduces exacerbations and hospital admissions in patients with severe chronic obstructive pulmonary disease and chronic bronchitis who are at risk of frequent and severe exacerbations despite inhaled corticosteroid and longacting β2 agonist therapy , even in combination with tiotropium . | [{'class': 'POS', 'spans': ['roflumilast', 'tiotropium'], 'is_context_needed': False}] |
This academic , matched-cohort study , compared 2-year outcomes of 11 consecutive IMN patients who received second-line rituximab therapy for NS persisting or relapsing after previous treatment with steroids alone or combined with alkylating agents , cyclosporine , or immunoglobulin G , with those of 11 age- ( ± 5 years ) , gender- and proteinuria- ( ± 1 g/24h ) matched reference patients given first-line rituximab therapy . | [] |
Induction chemotherapy with cisplatin , doxorubicin , and cyclophosphamide ( CAP ) in a combined modality approach for locally advanced and inflammatory breast cancer . | [{'class': 'POS', 'spans': ['cisplatin', 'doxorubicin', 'cyclophosphamide'], 'is_context_needed': True}] |
Methotrexate was efficient in one patient , hydroxychloroquine showed benefit in only 1 out of 3 patients . | [] |
Our results show high rates of DR-TB in Nigerian HIV-infected individuals ( 7.0 % for rifampin [ RIF ] and 9.3 % for RIF or isoniazid [ INH ] ) . | [] |
Sorafenib is an orally active multikinase inhibitor , and bortezomib is a proteasome inhibitor that affects multiple signaling pathways . | [] |
Hypertensive rats in separate groups were treated with either candesartan ( 1 mg/kg body weight ) alone or a combination of candesartan ( 1 mg/kg body weight ) and rofecoxib ( 10 mg/kg body weight ) orally and daily for 6 weeks . | [{'class': 'NEG', 'spans': ['candesartan', 'rofecoxib'], 'is_context_needed': True}] |
The highest weight gain in the cyclophosphamide , methotrexate and fluorouracil group was 2·9 kg ( 5 % ) vs. 0·9 kg ( 1 % ) in the anthracycline-based group . | [{'class': 'COMB', 'spans': ['cyclophosphamide', 'methotrexate', 'fluorouracil'], 'is_context_needed': True}] |
Treatment of relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma with everolimus ( RAD001 ) and alemtuzumab : a Phase I/II study . | [{'class': 'NEG', 'spans': ['everolimus', 'alemtuzumab'], 'is_context_needed': True}] |
Since primary amines similar to that of lisinopril readily form Schiff bases with acetaldehyde , these data suggest that both captopril and lisinopril may act to detoxify the acetaldehyde effect upon plasma , albeit by different mechanisms . | [] |
Capecitabine and oxaliplatin have been shown to be as effective as fluorouracil and cisplatin , respectively . | [{'class': 'POS', 'spans': ['Capecitabine', 'oxaliplatin'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': True}] |
To compare cardiopulmonary and sedative effects following administration of dexmedetomidine alone or with butorphanol , methadone , morphine or tramadol in healthy sheep . | [{'class': 'COMB', 'spans': ['dexmedetomidine', 'methadone'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 3], 'is_context_needed': True}] |
Subsets and Splits