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BigScience Biomedical Datasets 131

[ { "id": "NCT02982577_exc_text", "type": "exclusion", "text": [ "Sensitivity to pilocarpine\nSecondary Sjögren's syndrome;\nType II diabetes mellitus;\nAIDS;\npregnant or lactating women;\nGlaucoma;\nUncontrolled asthma;\nChronic obstructive pulmonary disease;\nRenal diseases;\nSevere cardiovascular diseases;\nGastrointestinal disorders;\nHepatic insufficiency.\n" ], "offsets": [ [ 0, 288 ] ] } ]

[ { "id": "NCT02982577_exc_T1", "type": "Condition", "text": [ "Sensitivity" ], "offsets": [ [ 0, 11 ] ], "normalized": [] }, { "id": "NCT02982577_exc_T2", "type": "Drug", "text": [ "pilocarpine" ], "offsets": [ [ 15, 26 ] ], "normalized": [] }, { "id": "NCT02982577_exc_T3", "type": "Condition", "text": [ "Sjögren's syndrome" ], "offsets": [ [ 37, 55 ] ], "normalized": [] }, { "id": "NCT02982577_exc_T4", "type": "Qualifier", "text": [ "Secondary" ], "offsets": [ [ 27, 36 ] ], "normalized": [] }, { "id": "NCT02982577_exc_T5", "type": "Condition", "text": [ "Type II diabetes mellitus" ], "offsets": [ [ 57, 82 ] ], "normalized": [] }, { "id": "NCT02982577_exc_T6", "type": "Condition", "text": [ "AIDS" ], "offsets": [ [ 84, 88 ] ], "normalized": [] }, { "id": "NCT02982577_exc_T8", "type": "Condition", "text": [ "Glaucoma" ], "offsets": [ [ 119, 127 ] ], "normalized": [] }, { "id": "NCT02982577_exc_T9", "type": "Condition", "text": [ "asthma" ], "offsets": [ [ 142, 148 ] ], "normalized": [] }, { "id": "NCT02982577_exc_T10", "type": "Qualifier", "text": [ "Uncontrolled" ], "offsets": [ [ 129, 141 ] ], "normalized": [] }, { "id": "NCT02982577_exc_T11", "type": "Condition", "text": [ "Chronic obstructive pulmonary disease" ], "offsets": [ [ 150, 187 ] ], "normalized": [] }, { "id": "NCT02982577_exc_T12", "type": "Condition", "text": [ "Renal diseases" ], "offsets": [ [ 189, 203 ] ], "normalized": [] }, { "id": "NCT02982577_exc_T13", "type": "Condition", "text": [ "cardiovascular diseases" ], "offsets": [ [ 212, 235 ] ], "normalized": [] }, { "id": "NCT02982577_exc_T14", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 205, 211 ] ], "normalized": [] }, { "id": "NCT02982577_exc_T15", "type": "Condition", "text": [ "Gastrointestinal disorders" ], "offsets": [ [ 237, 263 ] ], "normalized": [] }, { "id": "NCT02982577_exc_T16", "type": "Condition", "text": [ "Hepatic insufficiency" ], "offsets": [ [ 265, 286 ] ], "normalized": [] } ]

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[ { "id": "NCT02982577_exc_R1", "type": "AND", "arg1_id": "NCT02982577_exc_T1", "arg2_id": "NCT02982577_exc_T2", "normalized": [] }, { "id": "NCT02982577_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02982577_exc_T3", "arg2_id": "NCT02982577_exc_T4", "normalized": [] }, { "id": "NCT02982577_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02982577_exc_T9", "arg2_id": "NCT02982577_exc_T10", "normalized": [] }, { "id": "NCT02982577_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT02982577_exc_T13", "arg2_id": "NCT02982577_exc_T14", "normalized": [] } ]

[ { "id": "NCT02982577_inc_text", "type": "inclusion", "text": [ "Age equal or superior to 18 years;\nBoth genders;\nLucid and without diagnosis of any psychiatric disorder;\nDiagnosed with head and neck cancer and treated for a period of up to 5 years with radiotherapy where the major salivary glands (parotid, submandibular and sublingual) were included in the radiation field;\nPrimary Sjögren's syndrome with the diagnosis made by the American-European criteria.\n" ], "offsets": [ [ 0, 398 ] ] } ]

[ { "id": "NCT02982577_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02982577_inc_T2", "type": "Value", "text": [ "equal or superior to 18 years" ], "offsets": [ [ 4, 33 ] ], "normalized": [] }, { "id": "NCT02982577_inc_T3", "type": "Person", "text": [ "genders" ], "offsets": [ [ 40, 47 ] ], "normalized": [] }, { "id": "NCT02982577_inc_T4", "type": "Condition", "text": [ "psychiatric disorder" ], "offsets": [ [ 84, 104 ] ], "normalized": [] }, { "id": "NCT02982577_inc_T5", "type": "Negation", "text": [ "without" ], "offsets": [ [ 59, 66 ] ], "normalized": [] }, { "id": "NCT02982577_inc_T6", "type": "Condition", "text": [ "Lucid" ], "offsets": [ [ 49, 54 ] ], "normalized": [] }, { "id": "NCT02982577_inc_T7", "type": "Condition", "text": [ "head and neck cancer" ], "offsets": [ [ 121, 141 ] ], "normalized": [] }, { "id": "NCT02982577_inc_T8", "type": "Temporal", "text": [ "5 years" ], "offsets": [ [ 176, 183 ] ], "normalized": [] }, { "id": "NCT02982577_inc_T9", "type": "Procedure", "text": [ "radiotherapy" ], "offsets": [ [ 189, 201 ] ], "normalized": [] }, { "id": "NCT02982577_inc_T10", "type": "Qualifier", "text": [ "major salivary glands" ], "offsets": [ [ 212, 233 ] ], "normalized": [] }, { "id": "NCT02982577_inc_T11", "type": "Qualifier", "text": [ "parotid" ], "offsets": [ [ 235, 242 ] ], "normalized": [] }, { "id": "NCT02982577_inc_T12", "type": "Qualifier", "text": [ "submandibular" ], "offsets": [ [ 244, 257 ] ], "normalized": [] }, { "id": "NCT02982577_inc_T13", "type": "Qualifier", "text": [ "sublingual" ], "offsets": [ [ 262, 272 ] ], "normalized": [] }, { "id": "NCT02982577_inc_T14", "type": "Scope", "text": [ "parotid, submandibular and sublingual" ], "offsets": [ [ 235, 272 ] ], "normalized": [] }, { "id": "NCT02982577_inc_T15", "type": "Condition", "text": [ "Primary Sjögren's syndrome" ], "offsets": [ [ 312, 338 ] ], "normalized": [] }, { "id": "NCT02982577_inc_T16", "type": "Qualifier", "text": [ "American-European criteria" ], "offsets": [ [ 370, 396 ] ], "normalized": [] } ]

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[ { "id": "NCT02982577_inc_R1", "type": "Has_value", "arg1_id": "NCT02982577_inc_T1", "arg2_id": "NCT02982577_inc_T2", "normalized": [] }, { "id": "NCT02982577_inc_R2", "type": "Has_negation", "arg1_id": "NCT02982577_inc_T4", "arg2_id": "NCT02982577_inc_T5", "normalized": [] }, { "id": "NCT02982577_inc_R3", "type": "Has_temporal", "arg1_id": "NCT02982577_inc_T7", "arg2_id": "NCT02982577_inc_T8", "normalized": [] }, { "id": "NCT02982577_inc_R4", "type": "Subsumes", "arg1_id": "NCT02982577_inc_T10", "arg2_id": "NCT02982577_inc_T14", "normalized": [] }, { "id": "NCT02982577_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT02982577_inc_T9", "arg2_id": "NCT02982577_inc_T10", "normalized": [] }, { "id": "NCT02982577_inc_R6", "type": "AND", "arg1_id": "NCT02982577_inc_T7", "arg2_id": "NCT02982577_inc_T9", "normalized": [] }, { "id": "NCT02982577_inc_R7", "type": "Has_qualifier", "arg1_id": "NCT02982577_inc_T15", "arg2_id": "NCT02982577_inc_T16", "normalized": [] } ]

[ { "id": "NCT02983214_exc_text", "type": "exclusion", "text": [ "Congestive heart failure, history of ventricular tachycardia, ventricular fibrillation or multifocal ventricular extrasystoles or QTc prolongation.\nPatients with atrial fibrillation taking any anticoagulant therapy or patients with a history of cardioembolic ischemic stroke or hemorrhagic stroke.\nPatients with a history (= 12 months) of acute coronary syndrome receiving dual antiplatelet therapy, or patients receiving monotherapy with aspirin.\nPatients with hepatic impairment (child-Pugh staging, calibration = 5) or renal impairment (creatinine clearance = 30ml / min), recent peptic ulcer, a history of hypersensitivity to cilostazol, cancer patients undergoing treatment.\n" ], "offsets": [ [ 0, 680 ] ] } ]

[ { "id": "NCT02983214_exc_T1", "type": "Condition", "text": [ "Congestive heart failure" ], "offsets": [ [ 0, 24 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T2", "type": "Condition", "text": [ "ventricular tachycardia" ], "offsets": [ [ 37, 60 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T3", "type": "Observation", "text": [ "history of" ], "offsets": [ [ 26, 36 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T4", "type": "Condition", "text": [ "ventricular fibrillation" ], "offsets": [ [ 62, 86 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T5", "type": "Condition", "text": [ "multifocal ventricular extrasystoles" ], "offsets": [ [ 90, 126 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T6", "type": "Condition", "text": [ "QTc prolongation" ], "offsets": [ [ 130, 146 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T7", "type": "Condition", "text": [ "atrial fibrillation" ], "offsets": [ [ 162, 181 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T8", "type": "Procedure", "text": [ "anticoagulant therapy" ], "offsets": [ [ 193, 214 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T9", "type": "Observation", "text": [ "history of" ], "offsets": [ [ 234, 244 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T10", "type": "Condition", "text": [ "ischemic stroke" ], "offsets": [ [ 259, 274 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T11", "type": "Qualifier", "text": [ "cardioembolic" ], "offsets": [ [ 245, 258 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T12", "type": "Condition", "text": [ "hemorrhagic stroke" ], "offsets": [ [ 278, 296 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T13", "type": "Scope", "text": [ "cardioembolic ischemic stroke or hemorrhagic stroke" ], "offsets": [ [ 245, 296 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T14", "type": "Scope", "text": [ "atrial fibrillation taking any anticoagulant therapy" ], "offsets": [ [ 162, 214 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T15", "type": "Observation", "text": [ "history" ], "offsets": [ [ 314, 321 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T16", "type": "Temporal", "text": [ "= 12 months" ], "offsets": [ [ 323, 334 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T17", "type": "Condition", "text": [ "acute coronary syndrome" ], "offsets": [ [ 339, 362 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T18", "type": "Procedure", "text": [ "dual antiplatelet therapy" ], "offsets": [ [ 373, 398 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T19", "type": "Procedure", "text": [ "monotherapy" ], "offsets": [ [ 422, 433 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T20", "type": "Drug", "text": [ "aspirin" ], "offsets": [ [ 439, 446 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T21", "type": "Scope", "text": [ "acute coronary syndrome receiving dual antiplatelet therapy" ], "offsets": [ [ 339, 398 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T22", "type": "Scope", "text": [ "acute coronary syndrome receiving dual antiplatelet therapy, or patients receiving monotherapy with aspirin" ], "offsets": [ [ 339, 446 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T23", "type": "Condition", "text": [ "hepatic impairment" ], "offsets": [ [ 462, 480 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T24", "type": "Measurement", "text": [ "child-Pugh staging" ], "offsets": [ [ 482, 500 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T25", "type": "Value", "text": [ "calibration = 5" ], "offsets": [ [ 502, 517 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T26", "type": "Condition", "text": [ "renal impairment" ], "offsets": [ [ 522, 538 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T27", "type": "Measurement", "text": [ "creatinine clearance" ], "offsets": [ [ 540, 560 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T28", "type": "Value", "text": [ "= 30ml / min" ], "offsets": [ [ 561, 573 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T29", "type": "Temporal", "text": [ "recent" ], "offsets": [ [ 576, 582 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T30", "type": "Condition", "text": [ "peptic ulcer" ], "offsets": [ [ 583, 595 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T31", "type": "Observation", "text": [ "history of" ], "offsets": [ [ 599, 609 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T32", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 610, 626 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T33", "type": "Drug", "text": [ "cilostazol" ], "offsets": [ [ 630, 640 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T34", "type": "Condition", "text": [ "cancer" ], "offsets": [ [ 642, 648 ] ], "normalized": [] }, { "id": "NCT02983214_exc_T35", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 669, 678 ] ], "normalized": [] } ]

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[ { "id": "NCT02983214_exc_R1", "type": "Has_temporal", "arg1_id": "NCT02983214_exc_T2", "arg2_id": "NCT02983214_exc_T3", "normalized": [] }, { "id": "NCT02983214_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02983214_exc_T10", "arg2_id": "NCT02983214_exc_T11", "normalized": [] }, { "id": "NCT02983214_exc_R3", "type": "Has_temporal", "arg1_id": "NCT02983214_exc_T13", "arg2_id": "NCT02983214_exc_T9", "normalized": [] }, { "id": "NCT02983214_exc_R4", "type": "Subsumes", "arg1_id": "NCT02983214_exc_T15", "arg2_id": "NCT02983214_exc_T16", "normalized": [] }, { "id": "NCT02983214_exc_R5", "type": "AND", "arg1_id": "NCT02983214_exc_T19", "arg2_id": "NCT02983214_exc_T20", "normalized": [] }, { "id": "NCT02983214_exc_R6", "type": "Has_temporal", "arg1_id": "NCT02983214_exc_T22", "arg2_id": "NCT02983214_exc_T15", "normalized": [] }, { "id": "NCT02983214_exc_R7", "type": "Has_value", "arg1_id": "NCT02983214_exc_T24", "arg2_id": "NCT02983214_exc_T25", "normalized": [] }, { "id": "NCT02983214_exc_R8", "type": "Subsumes", "arg1_id": "NCT02983214_exc_T23", "arg2_id": "NCT02983214_exc_T24", "normalized": [] }, { "id": "NCT02983214_exc_R9", "type": "Has_value", "arg1_id": "NCT02983214_exc_T27", "arg2_id": "NCT02983214_exc_T28", "normalized": [] }, { "id": "NCT02983214_exc_R10", "type": "Subsumes", "arg1_id": "NCT02983214_exc_T26", "arg2_id": "NCT02983214_exc_T27", "normalized": [] }, { "id": "NCT02983214_exc_R11", "type": "Has_temporal", "arg1_id": "NCT02983214_exc_T30", "arg2_id": "NCT02983214_exc_T29", "normalized": [] }, { "id": "NCT02983214_exc_R12", "type": "AND", "arg1_id": "NCT02983214_exc_T34", "arg2_id": "NCT02983214_exc_T35", "normalized": [] }, { "id": "NCT02983214_exc_R13", "type": "AND", "arg1_id": "NCT02983214_exc_T32", "arg2_id": "NCT02983214_exc_T33", "normalized": [] }, { "id": "NCT02983214_exc_R14", "type": "Has_temporal", "arg1_id": "NCT02983214_exc_T32", "arg2_id": "NCT02983214_exc_T31", "normalized": [] } ]

[ { "id": "NCT02983214_inc_text", "type": "inclusion", "text": [ "Patients aged =50 years with DM2 and symptomatic PAD diagnosed clinically (according to Fontaine criteria, stage IIa or IIb and III) and by measuring the <U+0391><U+0392><U+0399>.\n" ], "offsets": [ [ 0, 180 ] ] } ]

[ { "id": "NCT02983214_inc_T1", "type": "Person", "text": [ "aged" ], "offsets": [ [ 9, 13 ] ], "normalized": [] }, { "id": "NCT02983214_inc_T2", "type": "Value", "text": [ "=50 years" ], "offsets": [ [ 14, 23 ] ], "normalized": [] }, { "id": "NCT02983214_inc_T3", "type": "Condition", "text": [ "DM2" ], "offsets": [ [ 29, 32 ] ], "normalized": [] }, { "id": "NCT02983214_inc_T4", "type": "Condition", "text": [ "PAD" ], "offsets": [ [ 49, 52 ] ], "normalized": [] }, { "id": "NCT02983214_inc_T5", "type": "Qualifier", "text": [ "symptomatic" ], "offsets": [ [ 37, 48 ] ], "normalized": [] }, { "id": "NCT02983214_inc_T6", "type": "Measurement", "text": [ "Fontaine criteria" ], "offsets": [ [ 88, 105 ] ], "normalized": [] }, { "id": "NCT02983214_inc_T7", "type": "Value", "text": [ "stage IIa or IIb and III" ], "offsets": [ [ 107, 131 ] ], "normalized": [] } ]

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[ { "id": "NCT02983214_inc_R1", "type": "Has_value", "arg1_id": "NCT02983214_inc_T1", "arg2_id": "NCT02983214_inc_T2", "normalized": [] }, { "id": "NCT02983214_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02983214_inc_T4", "arg2_id": "NCT02983214_inc_T5", "normalized": [] }, { "id": "NCT02983214_inc_R3", "type": "Has_value", "arg1_id": "NCT02983214_inc_T6", "arg2_id": "NCT02983214_inc_T7", "normalized": [] }, { "id": "NCT02983214_inc_R4", "type": "AND", "arg1_id": "NCT02983214_inc_T4", "arg2_id": "NCT02983214_inc_T6", "normalized": [] } ]

[ { "id": "NCT02984228_exc_text", "type": "exclusion", "text": [ "Non-English speaking/illiterate\nPainful active, concurrent cervical spine conditions\nCurrent non-steroidal anti-inflammatory drug (NSAID) use\nHistory of taking coumadin or similar anticoagulant, have a known coagulopathy, bleeding dyscrasia, or platelet count < 150,000/cubic mm\nAllergic reaction to poultry or previous viscosupplementation\nInvolved in workers' compensation or active litigation involving affected shoulder\nInability to refrain from NSAID use for 5 days prior to and 6 weeks after injection\nHistory of corticosteroid injection to affected shoulder within the last 3 months\nHistory of viscosupplementation or platelet-rich plasma to affected shoulder within the last 6 months\nPresence of acute fracture\nHistory of shoulder tumor\nKnown uncontrolled systemic illness (uncontrolled diabetes, human immunodeficiency virus, vasculitis, autoimmune/inflammatory disease)\nPsychiatric and somatoform disorders\n" ], "offsets": [ [ 0, 917 ] ] } ]

[ { "id": "NCT02984228_exc_T2", "type": "Condition", "text": [ "cervical spine conditions" ], "offsets": [ [ 59, 84 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T3", "type": "Condition", "text": [ "Painful" ], "offsets": [ [ 32, 39 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T4", "type": "Drug", "text": [ "non-steroidal anti-inflammatory drug" ], "offsets": [ [ 93, 129 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T5", "type": "Drug", "text": [ "NSAID" ], "offsets": [ [ 131, 136 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T6", "type": "Drug", "text": [ "coumadin" ], "offsets": [ [ 160, 168 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T7", "type": "Drug", "text": [ "anticoagulant" ], "offsets": [ [ 180, 193 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T8", "type": "Condition", "text": [ "coagulopathy" ], "offsets": [ [ 208, 220 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T9", "type": "Condition", "text": [ "bleeding dyscrasia" ], "offsets": [ [ 222, 240 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T10", "type": "Measurement", "text": [ "platelet count" ], "offsets": [ [ 245, 259 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T11", "type": "Value", "text": [ "< 150,000/cubic mm" ], "offsets": [ [ 260, 278 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T12", "type": "Condition", "text": [ "Allergic reaction" ], "offsets": [ [ 279, 296 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T13", "type": "Observation", "text": [ "viscosupplementation" ], "offsets": [ [ 320, 340 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T14", "type": "Observation", "text": [ "poultry" ], "offsets": [ [ 300, 307 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T15", "type": "Scope", "text": [ "poultry or previous viscosupplementation" ], "offsets": [ [ 300, 340 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T17", "type": "Drug", "text": [ "NSAID" ], "offsets": [ [ 450, 455 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T18", "type": "Temporal", "text": [ "5 days prior to and 6 weeks after injection" ], "offsets": [ [ 464, 507 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T19", "type": "Reference_point", "text": [ "injection" ], "offsets": [ [ 498, 507 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T20", "type": "Procedure", "text": [ "corticosteroid injection" ], "offsets": [ [ 519, 543 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T21", "type": "Temporal", "text": [ "last 3 months" ], "offsets": [ [ 576, 589 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T22", "type": "Qualifier", "text": [ "shoulder" ], "offsets": [ [ 556, 564 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T23", "type": "Procedure", "text": [ "viscosupplementation" ], "offsets": [ [ 601, 621 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T24", "type": "Drug", "text": [ "platelet-rich plasma" ], "offsets": [ [ 625, 645 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T25", "type": "Qualifier", "text": [ "shoulder" ], "offsets": [ [ 658, 666 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T26", "type": "Scope", "text": [ "viscosupplementation or platelet-rich plasma" ], "offsets": [ [ 601, 645 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T27", "type": "Temporal", "text": [ "last 6 months" ], "offsets": [ [ 678, 691 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T28", "type": "Condition", "text": [ "fracture" ], "offsets": [ [ 710, 718 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T29", "type": "Qualifier", "text": [ "acute" ], "offsets": [ [ 704, 709 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T30", "type": "Condition", "text": [ "systemic illness" ], "offsets": [ [ 764, 780 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T31", "type": "Qualifier", "text": [ "uncontrolled" ], "offsets": [ [ 751, 763 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T32", "type": "Qualifier", "text": [ "uncontrolled" ], "offsets": [ [ 782, 794 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T33", "type": "Condition", "text": [ "diabetes" ], "offsets": [ [ 795, 803 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T34", "type": "Condition", "text": [ "human immunodeficiency virus" ], "offsets": [ [ 805, 833 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T35", "type": "Condition", "text": [ "vasculitis" ], "offsets": [ [ 835, 845 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T36", "type": "Condition", "text": [ "autoimmune" ], "offsets": [ [ 847, 857 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T37", "type": "Condition", "text": [ "inflammatory disease" ], "offsets": [ [ 858, 878 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T38", "type": "Scope", "text": [ "uncontrolled diabetes, human immunodeficiency virus, vasculitis, autoimmune/inflammatory disease" ], "offsets": [ [ 782, 878 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T39", "type": "Condition", "text": [ "and somatof", "" ], "offsets": [ [ 892, 903 ], [ 919, 919 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T40", "type": "Condition", "text": [ "somatoform disorders" ], "offsets": [ [ 896, 916 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T41", "type": "Observation", "text": [ "History of" ], "offsets": [ [ 719, 729 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T42", "type": "Condition", "text": [ "shoulder tumor" ], "offsets": [ [ 730, 744 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T43", "type": "Mood", "text": [ "Inability to refrain from" ], "offsets": [ [ 424, 449 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T44", "type": "Observation", "text": [ "History of" ], "offsets": [ [ 508, 518 ] ], "normalized": [] }, { "id": "NCT02984228_exc_T45", "type": "Observation", "text": [ "History of" ], "offsets": [ [ 590, 600 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02984228_exc_R1", "type": "AND", "arg1_id": "NCT02984228_exc_T3", "arg2_id": "NCT02984228_exc_T2", "normalized": [] }, { "id": "NCT02984228_exc_R2", "type": "Subsumes", "arg1_id": "NCT02984228_exc_T4", "arg2_id": "NCT02984228_exc_T5", "normalized": [] }, { "id": "NCT02984228_exc_R3", "type": "Has_value", "arg1_id": "NCT02984228_exc_T10", "arg2_id": "NCT02984228_exc_T11", "normalized": [] }, { "id": "NCT02984228_exc_R4", "type": "Has_scope", "arg1_id": "NCT02984228_exc_T12", "arg2_id": "NCT02984228_exc_T15", "normalized": [] }, { "id": "NCT02984228_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02984228_exc_T17", "arg2_id": "NCT02984228_exc_T18", "normalized": [] }, { "id": "NCT02984228_exc_R6", "type": "Has_index", "arg1_id": "NCT02984228_exc_T18", "arg2_id": "NCT02984228_exc_T19", "normalized": [] }, { "id": "NCT02984228_exc_R7", "type": "Has_temporal", "arg1_id": "NCT02984228_exc_T20", "arg2_id": "NCT02984228_exc_T21", "normalized": [] }, { "id": "NCT02984228_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT02984228_exc_T20", "arg2_id": "NCT02984228_exc_T22", "normalized": [] }, { "id": "NCT02984228_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT02984228_exc_T26", "arg2_id": "NCT02984228_exc_T25", "normalized": [] }, { "id": "NCT02984228_exc_R10", "type": "Has_temporal", "arg1_id": "NCT02984228_exc_T26", "arg2_id": "NCT02984228_exc_T27", "normalized": [] }, { "id": "NCT02984228_exc_R11", "type": "Has_qualifier", "arg1_id": "NCT02984228_exc_T28", "arg2_id": "NCT02984228_exc_T29", "normalized": [] }, { "id": "NCT02984228_exc_R12", "type": "Has_qualifier", "arg1_id": "NCT02984228_exc_T30", "arg2_id": "NCT02984228_exc_T31", "normalized": [] }, { "id": "NCT02984228_exc_R13", "type": "Has_qualifier", "arg1_id": "NCT02984228_exc_T33", "arg2_id": "NCT02984228_exc_T32", "normalized": [] }, { "id": "NCT02984228_exc_R14", "type": "Subsumes", "arg1_id": "NCT02984228_exc_T30", "arg2_id": "NCT02984228_exc_T38", "normalized": [] }, { "id": "NCT02984228_exc_R15", "type": "Has_temporal", "arg1_id": "NCT02984228_exc_T42", "arg2_id": "NCT02984228_exc_T41", "normalized": [] }, { "id": "NCT02984228_exc_R16", "type": "Has_mood", "arg1_id": "NCT02984228_exc_T17", "arg2_id": "NCT02984228_exc_T43", "normalized": [] }, { "id": "NCT02984228_exc_R17", "type": "Has_temporal", "arg1_id": "NCT02984228_exc_T20", "arg2_id": "NCT02984228_exc_T44", "normalized": [] }, { "id": "NCT02984228_exc_R18", "type": "Has_temporal", "arg1_id": "NCT02984228_exc_T26", "arg2_id": "NCT02984228_exc_T45", "normalized": [] } ]

[ { "id": "NCT02984228_inc_text", "type": "inclusion", "text": [ "English speaking/literate\nAge 18-100 years\nVisual analog score pain >= 5\nGreater than or equal to 3 months of pain after onset of symptoms that has failed conservative treatments\nConfirmation of glenohumeral OA via imaging\nTransient relief of symptoms after diagnostic intra-articular injection into the glenohumeral joint\n" ], "offsets": [ [ 0, 323 ] ] } ]

[ { "id": "NCT02984228_inc_T2", "type": "Person", "text": [ "Age" ], "offsets": [ [ 26, 29 ] ], "normalized": [] }, { "id": "NCT02984228_inc_T3", "type": "Value", "text": [ "18-100 years" ], "offsets": [ [ 30, 42 ] ], "normalized": [] }, { "id": "NCT02984228_inc_T4", "type": "Measurement", "text": [ "Visual analog score pain" ], "offsets": [ [ 43, 67 ] ], "normalized": [] }, { "id": "NCT02984228_inc_T5", "type": "Value", "text": [ ">= 5" ], "offsets": [ [ 68, 72 ] ], "normalized": [] }, { "id": "NCT02984228_inc_T6", "type": "Condition", "text": [ "pain" ], "offsets": [ [ 110, 114 ] ], "normalized": [] }, { "id": "NCT02984228_inc_T7", "type": "Temporal", "text": [ "Greater than or equal to 3 months" ], "offsets": [ [ 73, 106 ] ], "normalized": [] }, { "id": "NCT02984228_inc_T8", "type": "Temporal", "text": [ "after onset of symptoms" ], "offsets": [ [ 115, 138 ] ], "normalized": [] }, { "id": "NCT02984228_inc_T9", "type": "Reference_point", "text": [ "onset of symptoms" ], "offsets": [ [ 121, 138 ] ], "normalized": [] }, { "id": "NCT02984228_inc_T10", "type": "Mood", "text": [ "failed" ], "offsets": [ [ 148, 154 ] ], "normalized": [] }, { "id": "NCT02984228_inc_T11", "type": "Procedure", "text": [ "conservative treatments" ], "offsets": [ [ 155, 178 ] ], "normalized": [] }, { "id": "NCT02984228_inc_T12", "type": "Condition", "text": [ "glenohumeral OA" ], "offsets": [ [ 195, 210 ] ], "normalized": [] }, { "id": "NCT02984228_inc_T13", "type": "Procedure", "text": [ "imaging" ], "offsets": [ [ 215, 222 ] ], "normalized": [] }, { "id": "NCT02984228_inc_T14", "type": "Procedure", "text": [ "intra-articular injection" ], "offsets": [ [ 269, 294 ] ], "normalized": [] }, { "id": "NCT02984228_inc_T15", "type": "Qualifier", "text": [ "glenohumeral joint" ], "offsets": [ [ 304, 322 ] ], "normalized": [] }, { "id": "NCT02984228_inc_T16", "type": "Condition", "text": [ "relief of symptoms" ], "offsets": [ [ 233, 251 ] ], "normalized": [] }, { "id": "NCT02984228_inc_T17", "type": "Qualifier", "text": [ "Transient" ], "offsets": [ [ 223, 232 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02984228_inc_R1", "type": "Has_value", "arg1_id": "NCT02984228_inc_T2", "arg2_id": "NCT02984228_inc_T3", "normalized": [] }, { "id": "NCT02984228_inc_R2", "type": "Has_value", "arg1_id": "NCT02984228_inc_T4", "arg2_id": "NCT02984228_inc_T5", "normalized": [] }, { "id": "NCT02984228_inc_R3", "type": "Has_temporal", "arg1_id": "NCT02984228_inc_T6", "arg2_id": "NCT02984228_inc_T7", "normalized": [] }, { "id": "NCT02984228_inc_R4", "type": "Has_index", "arg1_id": "NCT02984228_inc_T8", "arg2_id": "NCT02984228_inc_T9", "normalized": [] }, { "id": "NCT02984228_inc_R5", "type": "Has_temporal", "arg1_id": "NCT02984228_inc_T6", "arg2_id": "NCT02984228_inc_T8", "normalized": [] }, { "id": "NCT02984228_inc_R6", "type": "Has_mood", "arg1_id": "NCT02984228_inc_T11", "arg2_id": "NCT02984228_inc_T10", "normalized": [] }, { "id": "NCT02984228_inc_R7", "type": "AND", "arg1_id": "NCT02984228_inc_T6", "arg2_id": "NCT02984228_inc_T11", "normalized": [] }, { "id": "NCT02984228_inc_R8", "type": "AND", "arg1_id": "NCT02984228_inc_T13", "arg2_id": "NCT02984228_inc_T12", "normalized": [] }, { "id": "NCT02984228_inc_R9", "type": "Has_qualifier", "arg1_id": "NCT02984228_inc_T14", "arg2_id": "NCT02984228_inc_T15", "normalized": [] }, { "id": "NCT02984228_inc_R10", "type": "Has_qualifier", "arg1_id": "NCT02984228_inc_T16", "arg2_id": "NCT02984228_inc_T17", "normalized": [] }, { "id": "NCT02984228_inc_R11", "type": "AND", "arg1_id": "NCT02984228_inc_T16", "arg2_id": "NCT02984228_inc_T14", "normalized": [] } ]

[ { "id": "NCT02984475_exc_text", "type": "exclusion", "text": [ "Patients with renal impairment (serum creatinine more than twice the upper limit of normal).\nPatients with heart failure.\nPatients with sepsis or active infection.\nPatients with diabetes mellitus (either primary or secondary to thalassemia).\nregular consumption of medication with potential hepatotoxicity.\nregular herbal medicine or antioxidant supplementation.\npatients with gastrointestinal conditions preventing adsorption of oral medication.\n" ], "offsets": [ [ 0, 447 ] ] } ]

[ { "id": "NCT02984475_exc_T1", "type": "Condition", "text": [ "renal impairment" ], "offsets": [ [ 14, 30 ] ], "normalized": [] }, { "id": "NCT02984475_exc_T2", "type": "Measurement", "text": [ "serum creatinine" ], "offsets": [ [ 32, 48 ] ], "normalized": [] }, { "id": "NCT02984475_exc_T3", "type": "Value", "text": [ "more than twice the upper limit of normal" ], "offsets": [ [ 49, 90 ] ], "normalized": [] }, { "id": "NCT02984475_exc_T4", "type": "Condition", "text": [ "heart failure" ], "offsets": [ [ 107, 120 ] ], "normalized": [] }, { "id": "NCT02984475_exc_T5", "type": "Condition", "text": [ "sepsis" ], "offsets": [ [ 136, 142 ] ], "normalized": [] }, { "id": "NCT02984475_exc_T6", "type": "Condition", "text": [ "active infection" ], "offsets": [ [ 146, 162 ] ], "normalized": [] }, { "id": "NCT02984475_exc_T7", "type": "Condition", "text": [ "diabetes mellitus" ], "offsets": [ [ 178, 195 ] ], "normalized": [] }, { "id": "NCT02984475_exc_T8", "type": "Qualifier", "text": [ "primary" ], "offsets": [ [ 204, 211 ] ], "normalized": [] }, { "id": "NCT02984475_exc_T9", "type": "Qualifier", "text": [ "secondary to thalassemia" ], "offsets": [ [ 215, 239 ] ], "normalized": [] }, { "id": "NCT02984475_exc_T10", "type": "Scope", "text": [ "primary or secondary to thalassemia" ], "offsets": [ [ 204, 239 ] ], "normalized": [] }, { "id": "NCT02984475_exc_T11", "type": "Condition", "text": [ "hepatotoxicity" ], "offsets": [ [ 291, 305 ] ], "normalized": [] }, { "id": "NCT02984475_exc_T12", "type": "Drug", "text": [ "medication" ], "offsets": [ [ 265, 275 ] ], "normalized": [] }, { "id": "NCT02984475_exc_T13", "type": "Drug", "text": [ "antioxidant supplementation" ], "offsets": [ [ 334, 361 ] ], "normalized": [] }, { "id": "NCT02984475_exc_T14", "type": "Procedure", "text": [ "herbal medicine" ], "offsets": [ [ 315, 330 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02984475_exc_R1", "type": "Has_value", "arg1_id": "NCT02984475_exc_T2", "arg2_id": "NCT02984475_exc_T3", "normalized": [] }, { "id": "NCT02984475_exc_R2", "type": "AND", "arg1_id": "NCT02984475_exc_T1", "arg2_id": "NCT02984475_exc_T2", "normalized": [] }, { "id": "NCT02984475_exc_R3", "type": "Has_scope", "arg1_id": "NCT02984475_exc_T7", "arg2_id": "NCT02984475_exc_T10", "normalized": [] }, { "id": "NCT02984475_exc_R4", "type": "AND", "arg1_id": "NCT02984475_exc_T11", "arg2_id": "NCT02984475_exc_T12", "normalized": [] } ]

[ { "id": "NCT02984475_inc_text", "type": "inclusion", "text": [ "Diagnosed with Beta-Thalassemia Major and receiving regular blood transfusion and on iron chelating therapy.\nWeight: equal to or over 35 kg.\nNormal renal function.\n" ], "offsets": [ [ 0, 164 ] ] } ]

[ { "id": "NCT02984475_inc_T1", "type": "Condition", "text": [ "Beta-Thalassemia Major" ], "offsets": [ [ 15, 37 ] ], "normalized": [] }, { "id": "NCT02984475_inc_T2", "type": "Procedure", "text": [ "blood transfusion" ], "offsets": [ [ 60, 77 ] ], "normalized": [] }, { "id": "NCT02984475_inc_T3", "type": "Qualifier", "text": [ "regular" ], "offsets": [ [ 52, 59 ] ], "normalized": [] }, { "id": "NCT02984475_inc_T4", "type": "Procedure", "text": [ "iron chelating therapy" ], "offsets": [ [ 85, 107 ] ], "normalized": [] }, { "id": "NCT02984475_inc_T5", "type": "Scope", "text": [ "blood transfusion and on iron chelating therapy" ], "offsets": [ [ 60, 107 ] ], "normalized": [] }, { "id": "NCT02984475_inc_T6", "type": "Person", "text": [ "Weight" ], "offsets": [ [ 109, 115 ] ], "normalized": [] }, { "id": "NCT02984475_inc_T7", "type": "Value", "text": [ "equal to or over 35 kg" ], "offsets": [ [ 117, 139 ] ], "normalized": [] }, { "id": "NCT02984475_inc_T8", "type": "Condition", "text": [ "renal function" ], "offsets": [ [ 148, 162 ] ], "normalized": [] }, { "id": "NCT02984475_inc_T9", "type": "Qualifier", "text": [ "Normal" ], "offsets": [ [ 141, 147 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02984475_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT02984475_inc_T5", "arg2_id": "NCT02984475_inc_T3", "normalized": [] }, { "id": "NCT02984475_inc_R2", "type": "Has_scope", "arg1_id": "NCT02984475_inc_T1", "arg2_id": "NCT02984475_inc_T5", "normalized": [] }, { "id": "NCT02984475_inc_R3", "type": "Has_value", "arg1_id": "NCT02984475_inc_T6", "arg2_id": "NCT02984475_inc_T7", "normalized": [] }, { "id": "NCT02984475_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT02984475_inc_T8", "arg2_id": "NCT02984475_inc_T9", "normalized": [] } ]

[ { "id": "NCT02985242_exc_text", "type": "exclusion", "text": [ "Type 1 diabetes\nuncontrolled diabetes mellitus type 2 with fasting glucose > 13.3 mmol/l confirmed on a second day\nknown or suspected hypersensitivity to empagliflozin, glimepiride, or any excipients; and / or known or suspected hypersensitivity to sulfonylureas, sulfonamides or SGLT2 inhibitors in general\nhistory of multiple severe hypoglycemic episodes within the last two years\nuse of Insulin, SGLT2-inhibitor, sulfonylurea derivate or a glinide within past 3 months\nclinical significant macular edema in both eyes and indication for intravitreal anti-VEGF treatment for both eyes at screening or baseline visit. Eyes with a small amount of intraretinal or subretinal fluid (seen in OCT) but no need for intravitreal treatment as judged by the investigator (according to current practice patterns) may be included. Eyes with a history of intravitreal treatment of macular edema which do not need ongoing intravitreal treatment at the time of screening may be included.\neye diseases or pathologies that prevent clear ophthalmoscopy and evaluation of study parameters, thus not allowing study participation according to the investigator´s judgment, such as (but not only) vitreous hemorrhage, mature cataract, macular pathologies other than diabetic maculopathy\nhistory of ketoacidosis or metabolic acidosis\nuse of loop diuretics\nhistory of > 1 urogenital infection/year\nany history of stroke, transient ischemic attack (TIA), instable angina pectoris or myocardial infarction within last 3 months prior to baseline visit\ncongestive heart failure New York Heart Association (NYHA) III and IV\nsevere valvular or left ventricular outflow obstruction disease needing intervention;\natrial fibrillation/flutter with a mean ventricular response rate at rest >100 beats per minute\nchronic lower urinary tract infections (but not simple asymptomatic bacteriuria)\neGFR < 60 ml/min/1,73 m2 (MDRD-formula, confirmed on a second day)\nchronic diarrhea, any clinical signs of volume depletion or a hematocrit > 48 % (women) and > 53 % (men)\nelevated risk for volume depletion, e.g. history of severe volume depletion that required medical therapy\nchronic liver disease (including known active hepatitis) and/or screening alanine transaminase (ALT) or aspartate transaminase (AST) > 3 x upper limit of normal (ULN) (confirmed on a second day)\nSubjects with known seropositivity to human immunodeficiency virus.\nacute illness at screening or randomization according to judgement by the investigator or patient\ndrug or alcohol abuse\npsychosomatic or psychiatric diseases requiring hospitalization during the last 12 months\nclinical evidence of current malignancy with exception of basal cell or squamous cell carcinoma of the skin, and cervical intraepithelial neoplasia (5 years prior to randomization)\nany medical or surgical intervention planned for the next 13 months after randomization not allowing study participation according to the investigator´s judgment\ncurrent participation in any other clinical trial or participation in another clinical trial within 30 days before screening\n" ], "offsets": [ [ 0, 3077 ] ] } ]

[ { "id": "NCT02985242_exc_T1", "type": "Condition", "text": [ "Type 1 diabetes" ], "offsets": [ [ 0, 15 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T2", "type": "Condition", "text": [ "diabetes mellitus type 2" ], "offsets": [ [ 29, 53 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T3", "type": "Qualifier", "text": [ "uncontrolled" ], "offsets": [ [ 16, 28 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T4", "type": "Measurement", "text": [ "fasting glucose" ], "offsets": [ [ 59, 74 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T5", "type": "Value", "text": [ "> 13.3 mmol/l" ], "offsets": [ [ 75, 88 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T6", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 134, 150 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T7", "type": "Drug", "text": [ "empagliflozin" ], "offsets": [ [ 154, 167 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T8", "type": "Drug", "text": [ "glimepiride" ], "offsets": [ [ 169, 180 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T9", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 229, 245 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T10", "type": "Drug", "text": [ "sulfonylureas" ], "offsets": [ [ 249, 262 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T11", "type": "Drug", "text": [ "sulfonamides" ], "offsets": [ [ 264, 276 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T12", "type": "Drug", "text": [ "SGLT2 inhibitors" ], "offsets": [ [ 280, 296 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T13", "type": "Scope", "text": [ "sulfonylureas, sulfonamides or SGLT2 inhibitors" ], "offsets": [ [ 249, 296 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T14", "type": "Scope", "text": [ "empagliflozin, glimepiride" ], "offsets": [ [ 154, 180 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T15", "type": "Condition", "text": [ "hypoglycemic episodes" ], "offsets": [ [ 335, 356 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T16", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 328, 334 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T17", "type": "Multiplier", "text": [ "multiple" ], "offsets": [ [ 319, 327 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T18", "type": "Temporal", "text": [ "last two years" ], "offsets": [ [ 368, 382 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T19", "type": "Drug", "text": [ "Insulin" ], "offsets": [ [ 390, 397 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T20", "type": "Drug", "text": [ "SGLT2-inhibitor" ], "offsets": [ [ 399, 414 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T21", "type": "Drug", "text": [ "sulfonylurea derivate" ], "offsets": [ [ 416, 437 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T22", "type": "Drug", "text": [ "glinide" ], "offsets": [ [ 443, 450 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T23", "type": "Scope", "text": [ "Insulin, SGLT2-inhibitor, sulfonylurea derivate or a glinide" ], "offsets": [ [ 390, 450 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T24", "type": "Temporal", "text": [ "past 3 months" ], "offsets": [ [ 458, 471 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T25", "type": "Condition", "text": [ "macular edema" ], "offsets": [ [ 493, 506 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T26", "type": "Qualifier", "text": [ "both eyes" ], "offsets": [ [ 510, 519 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T27", "type": "Procedure", "text": [ "intravitreal anti-VEGF treatment" ], "offsets": [ [ 539, 571 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T28", "type": "Qualifier", "text": [ "both eyes" ], "offsets": [ [ 576, 585 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T30", "type": "Negation", "text": [ "prevent" ], "offsets": [ [ 1007, 1014 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T31", "type": "Procedure", "text": [ "ophthalmoscopy" ], "offsets": [ [ 1021, 1035 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T32", "type": "Condition", "text": [ "vitreous hemorrhage" ], "offsets": [ [ 1175, 1194 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T33", "type": "Condition", "text": [ "mature cataract" ], "offsets": [ [ 1196, 1211 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T34", "type": "Condition", "text": [ "macular pathologies" ], "offsets": [ [ 1213, 1232 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T35", "type": "Negation", "text": [ "other" ], "offsets": [ [ 1233, 1238 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T36", "type": "Condition", "text": [ "diabetic maculopathy" ], "offsets": [ [ 1244, 1264 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T37", "type": "Condition", "text": [ "ketoacidosis" ], "offsets": [ [ 1276, 1288 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T38", "type": "Condition", "text": [ "metabolic acidosis" ], "offsets": [ [ 1292, 1310 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T39", "type": "Drug", "text": [ "loop diuretics" ], "offsets": [ [ 1318, 1332 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T40", "type": "Condition", "text": [ "urogenital infection" ], "offsets": [ [ 1348, 1368 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T41", "type": "Multiplier", "text": [ "nit", " his" ], "offsets": [ [ 1353, 1356 ], [ 1377, 1381 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T42", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 1389, 1395 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T43", "type": "Condition", "text": [ "transient ischemic attack" ], "offsets": [ [ 1397, 1422 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T44", "type": "Condition", "text": [ "TIA" ], "offsets": [ [ 1424, 1427 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T45", "type": "Condition", "text": [ "angina pectoris" ], "offsets": [ [ 1439, 1454 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T46", "type": "Qualifier", "text": [ "instable" ], "offsets": [ [ 1430, 1438 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T47", "type": "Condition", "text": [ "myocardial infarction" ], "offsets": [ [ 1458, 1479 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T48", "type": "Temporal", "text": [ "last 3 months prior to baseline visit" ], "offsets": [ [ 1487, 1524 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T49", "type": "Reference_point", "text": [ "baseline visit" ], "offsets": [ [ 1510, 1524 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T50", "type": "Scope", "text": [ "stroke, transient ischemic attack (TIA), instable angina pectoris or myocardial infarction" ], "offsets": [ [ 1389, 1479 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T51", "type": "Condition", "text": [ "congestive heart failure" ], "offsets": [ [ 1525, 1549 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T52", "type": "Measurement", "text": [ "New York Heart Association" ], "offsets": [ [ 1550, 1576 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T53", "type": "Measurement", "text": [ "NYHA" ], "offsets": [ [ 1578, 1582 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T54", "type": "Value", "text": [ "III and IV" ], "offsets": [ [ 1584, 1594 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T55", "type": "Condition", "text": [ "left ventricular outflow obstruction" ], "offsets": [ [ 1614, 1650 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T56", "type": "Condition", "text": [ "left ven", "ing int" ], "offsets": [ [ 1614, 1622 ], [ 1663, 1670 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T57", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 1595, 1601 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T58", "type": "Scope", "text": [ "valvular or left ventricular outflow obstruction disease" ], "offsets": [ [ 1602, 1658 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T59", "type": "Procedure", "text": [ "intervention" ], "offsets": [ [ 1667, 1679 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T60", "type": "Condition", "text": [ "atrial fibrillation" ], "offsets": [ [ 1681, 1700 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T61", "type": "Condition", "text": [ "lation", "a mean" ], "offsets": [ [ 1694, 1700 ], [ 1714, 1720 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T62", "type": "Measurement", "text": [ "mean ventricular response rate" ], "offsets": [ [ 1716, 1746 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T63", "type": "Qualifier", "text": [ "at rest" ], "offsets": [ [ 1747, 1754 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T64", "type": "Value", "text": [ ">100 beats per minute" ], "offsets": [ [ 1755, 1776 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T65", "type": "Scope", "text": [ "atrial fibrillation/flutter" ], "offsets": [ [ 1681, 1708 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T66", "type": "Condition", "text": [ "lower urinary tract infections" ], "offsets": [ [ 1785, 1815 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T67", "type": "Qualifier", "text": [ "chronic" ], "offsets": [ [ 1777, 1784 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T68", "type": "Negation", "text": [ "not" ], "offsets": [ [ 1821, 1824 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T69", "type": "Condition", "text": [ "asymptomatic bacteriuria" ], "offsets": [ [ 1832, 1856 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T70", "type": "Measurement", "text": [ "eGFR" ], "offsets": [ [ 1858, 1862 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T71", "type": "Value", "text": [ "< 60 ml/min/1,73 m2" ], "offsets": [ [ 1863, 1882 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T72", "type": "Condition", "text": [ "chronic diarrhea" ], "offsets": [ [ 1925, 1941 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T73", "type": "Condition", "text": [ "volume depletion" ], "offsets": [ [ 1965, 1981 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T74", "type": "Measurement", "text": [ "hematocrit" ], "offsets": [ [ 1987, 1997 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T75", "type": "Value", "text": [ "> 48 %" ], "offsets": [ [ 1998, 2004 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T76", "type": "Person", "text": [ "women" ], "offsets": [ [ 2006, 2011 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T77", "type": "Value", "text": [ "> 53 %" ], "offsets": [ [ 2017, 2023 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T78", "type": "Person", "text": [ "men" ], "offsets": [ [ 2025, 2028 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T79", "type": "Measurement", "text": [ "hematocrit" ], "offsets": [ [ 1987, 1997 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T80", "type": "Scope", "text": [ "hematocrit > 48 % (women) and > 53 % (men)" ], "offsets": [ [ 1987, 2029 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T81", "type": "Observation", "text": [ "risk for volume depletion," ], "offsets": [ [ 2039, 2065 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T82", "type": "Qualifier", "text": [ "elevated" ], "offsets": [ [ 2030, 2038 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T83", "type": "Condition", "text": [ "chronic liver disease" ], "offsets": [ [ 2136, 2157 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T84", "type": "Condition", "text": [ "active hepatitis" ], "offsets": [ [ 2175, 2191 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T85", "type": "Measurement", "text": [ "alanine transaminase" ], "offsets": [ [ 2210, 2230 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T86", "type": "Measurement", "text": [ "ALT" ], "offsets": [ [ 2232, 2235 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T87", "type": "Measurement", "text": [ "aspartate transaminase" ], "offsets": [ [ 2240, 2262 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T88", "type": "Measurement", "text": [ "AST" ], "offsets": [ [ 2264, 2267 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T89", "type": "Value", "text": [ "> 3 x upper limit of normal" ], "offsets": [ [ 2269, 2296 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T90", "type": "Scope", "text": [ "alanine transaminase (ALT) or aspartate transaminase (AST)" ], "offsets": [ [ 2210, 2268 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T91", "type": "Measurement", "text": [ "human immunodeficiency virus" ], "offsets": [ [ 2369, 2397 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T92", "type": "Value", "text": [ "seropositivity" ], "offsets": [ [ 2351, 2365 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T94", "type": "Condition", "text": [ "alcohol abuse" ], "offsets": [ [ 2505, 2518 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T95", "type": "Condition", "text": [ "\nps", "r psy" ], "offsets": [ [ 2518, 2521 ], [ 2534, 2539 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T96", "type": "Condition", "text": [ "psychiatric diseases" ], "offsets": [ [ 2536, 2556 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T97", "type": "Condition", "text": [ "iatric diseas", "pitaliza" ], "offsets": [ [ 2541, 2554 ], [ 2570, 2578 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T98", "type": "Visit", "text": [ "hospitalization" ], "offsets": [ [ 2567, 2582 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T99", "type": "Temporal", "text": [ "last 12 months" ], "offsets": [ [ 2594, 2608 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T100", "type": "Scope", "text": [ "psychosomatic or psychiatric diseases" ], "offsets": [ [ 2519, 2556 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T101", "type": "Condition", "text": [ "malignancy" ], "offsets": [ [ 2638, 2648 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T102", "type": "Negation", "text": [ "exception" ], "offsets": [ [ 2654, 2663 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T103", "type": "Condition", "text": [ "cell carci", "and cervi", "al intraepi" ], "offsets": [ [ 2690, 2700 ], [ 2718, 2727 ], [ 2728, 2739 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T104", "type": "Condition", "text": [ "squamous cell carcinoma of the skin" ], "offsets": [ [ 2681, 2716 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T105", "type": "Condition", "text": [ "cervical intraepithelial neoplasia" ], "offsets": [ [ 2722, 2756 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T106", "type": "Temporal", "text": [ "5 years prior to randomization" ], "offsets": [ [ 2758, 2788 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T107", "type": "Reference_point", "text": [ "randomization" ], "offsets": [ [ 2775, 2788 ] ], "normalized": [] }, { "id": "NCT02985242_exc_T108", "type": "Scope", "text": [ "basal cell or squamous cell carcinoma of the skin, and cervical intraepithelial neoplasia" ], "offsets": [ [ 2667, 2756 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02985242_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02985242_exc_T2", "arg2_id": "NCT02985242_exc_T3", "normalized": [] }, { "id": "NCT02985242_exc_R2", "type": "Has_value", "arg1_id": "NCT02985242_exc_T4", "arg2_id": "NCT02985242_exc_T5", "normalized": [] }, { "id": "NCT02985242_exc_R3", "type": "AND", "arg1_id": "NCT02985242_exc_T2", "arg2_id": "NCT02985242_exc_T4", "normalized": [] }, { "id": "NCT02985242_exc_R4", "type": "Has_scope", "arg1_id": "NCT02985242_exc_T9", "arg2_id": "NCT02985242_exc_T13", "normalized": [] }, { "id": "NCT02985242_exc_R5", "type": "Has_scope", "arg1_id": "NCT02985242_exc_T6", "arg2_id": "NCT02985242_exc_T14", "normalized": [] }, { "id": "NCT02985242_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02985242_exc_T15", "arg2_id": "NCT02985242_exc_T16", "normalized": [] }, { "id": "NCT02985242_exc_R7", "type": "Has_multiplier", "arg1_id": "NCT02985242_exc_T15", "arg2_id": "NCT02985242_exc_T17", "normalized": [] }, { "id": "NCT02985242_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02985242_exc_T15", "arg2_id": "NCT02985242_exc_T18", "normalized": [] }, { "id": "NCT02985242_exc_R9", "type": "Has_temporal", "arg1_id": "NCT02985242_exc_T23", "arg2_id": "NCT02985242_exc_T24", "normalized": [] }, { "id": "NCT02985242_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT02985242_exc_T25", "arg2_id": "NCT02985242_exc_T26", "normalized": [] }, { "id": "NCT02985242_exc_R11", "type": "Has_qualifier", "arg1_id": "NCT02985242_exc_T27", "arg2_id": "NCT02985242_exc_T28", "normalized": [] }, { "id": "NCT02985242_exc_R12", "type": "Has_negation", "arg1_id": "NCT02985242_exc_T31", "arg2_id": "NCT02985242_exc_T30", "normalized": [] }, { "id": "NCT02985242_exc_R13", "type": "Has_negation", "arg1_id": "NCT02985242_exc_T36", "arg2_id": "NCT02985242_exc_T35", "normalized": [] }, { "id": "NCT02985242_exc_R14", "type": "Has_multiplier", "arg1_id": "NCT02985242_exc_T40", "arg2_id": "NCT02985242_exc_T41", "normalized": [] }, { "id": "NCT02985242_exc_R15", "type": "Has_index", "arg1_id": "NCT02985242_exc_T48", "arg2_id": "NCT02985242_exc_T49", "normalized": [] }, { "id": "NCT02985242_exc_R16", "type": "Subsumes", "arg1_id": "NCT02985242_exc_T43", "arg2_id": "NCT02985242_exc_T44", "normalized": [] }, { "id": "NCT02985242_exc_R17", "type": "Has_qualifier", "arg1_id": "NCT02985242_exc_T45", "arg2_id": "NCT02985242_exc_T46", "normalized": [] }, { "id": "NCT02985242_exc_R18", "type": "Has_temporal", "arg1_id": "NCT02985242_exc_T50", "arg2_id": "NCT02985242_exc_T48", "normalized": [] }, { "id": "NCT02985242_exc_R19", "type": "Subsumes", "arg1_id": "NCT02985242_exc_T52", "arg2_id": "NCT02985242_exc_T53", "normalized": [] }, { "id": "NCT02985242_exc_R20", "type": "Has_value", "arg1_id": "NCT02985242_exc_T52", "arg2_id": "NCT02985242_exc_T54", "normalized": [] }, { "id": "NCT02985242_exc_R21", "type": "AND", "arg1_id": "NCT02985242_exc_T51", "arg2_id": "NCT02985242_exc_T52", "normalized": [] }, { "id": "NCT02985242_exc_R22", "type": "Has_qualifier", "arg1_id": "NCT02985242_exc_T58", "arg2_id": "NCT02985242_exc_T57", "normalized": [] }, { "id": "NCT02985242_exc_R23", "type": "AND", "arg1_id": "NCT02985242_exc_T58", "arg2_id": "NCT02985242_exc_T59", "normalized": [] }, { "id": "NCT02985242_exc_R24", "type": "Has_qualifier", "arg1_id": "NCT02985242_exc_T62", "arg2_id": "NCT02985242_exc_T63", "normalized": [] }, { "id": "NCT02985242_exc_R25", "type": "Has_value", "arg1_id": "NCT02985242_exc_T62", "arg2_id": "NCT02985242_exc_T64", "normalized": [] }, { "id": "NCT02985242_exc_R26", "type": "AND", "arg1_id": "NCT02985242_exc_T65", "arg2_id": "NCT02985242_exc_T62", "normalized": [] }, { "id": "NCT02985242_exc_R27", "type": "Has_qualifier", "arg1_id": "NCT02985242_exc_T66", "arg2_id": "NCT02985242_exc_T67", "normalized": [] }, { "id": "NCT02985242_exc_R28", "type": "Has_negation", "arg1_id": "NCT02985242_exc_T69", "arg2_id": "NCT02985242_exc_T68", "normalized": [] }, { "id": "NCT02985242_exc_R29", "type": "Has_value", "arg1_id": "NCT02985242_exc_T70", "arg2_id": "NCT02985242_exc_T71", "normalized": [] }, { "id": "NCT02985242_exc_R30", "type": "AND", "arg1_id": "NCT02985242_exc_T79", "arg2_id": "NCT02985242_exc_T76", "normalized": [] }, { "id": "NCT02985242_exc_R31", "type": "Has_value", "arg1_id": "NCT02985242_exc_T79", "arg2_id": "NCT02985242_exc_T75", "normalized": [] }, { "id": "NCT02985242_exc_R32", "type": "AND", "arg1_id": "NCT02985242_exc_T74", "arg2_id": "NCT02985242_exc_T78", "normalized": [] }, { "id": "NCT02985242_exc_R33", "type": "Has_value", "arg1_id": "NCT02985242_exc_T74", "arg2_id": "NCT02985242_exc_T77", "normalized": [] }, { "id": "NCT02985242_exc_R34", "type": "Has_qualifier", "arg1_id": "NCT02985242_exc_T81", "arg2_id": "NCT02985242_exc_T82", "normalized": [] }, { "id": "NCT02985242_exc_R35", "type": "Subsumes", "arg1_id": "NCT02985242_exc_T83", "arg2_id": "NCT02985242_exc_T84", "normalized": [] }, { "id": "NCT02985242_exc_R36", "type": "Subsumes", "arg1_id": "NCT02985242_exc_T85", "arg2_id": "NCT02985242_exc_T86", "normalized": [] }, { "id": "NCT02985242_exc_R37", "type": "Subsumes", "arg1_id": "NCT02985242_exc_T87", "arg2_id": "NCT02985242_exc_T88", "normalized": [] }, { "id": "NCT02985242_exc_R38", "type": "Has_value", "arg1_id": "NCT02985242_exc_T90", "arg2_id": "NCT02985242_exc_T89", "normalized": [] }, { "id": "NCT02985242_exc_R39", "type": "Has_value", "arg1_id": "NCT02985242_exc_T91", "arg2_id": "NCT02985242_exc_T92", "normalized": [] }, { "id": "NCT02985242_exc_R40", "type": "Has_temporal", "arg1_id": "NCT02985242_exc_T98", "arg2_id": "NCT02985242_exc_T99", "normalized": [] }, { "id": "NCT02985242_exc_R41", "type": "Has_index", "arg1_id": "NCT02985242_exc_T106", "arg2_id": "NCT02985242_exc_T107", "normalized": [] }, { "id": "NCT02985242_exc_R42", "type": "Has_temporal", "arg1_id": "NCT02985242_exc_T101", "arg2_id": "NCT02985242_exc_T106", "normalized": [] }, { "id": "NCT02985242_exc_R43", "type": "Has_negation", "arg1_id": "NCT02985242_exc_T108", "arg2_id": "NCT02985242_exc_T102", "normalized": [] } ]

[ { "id": "NCT02985242_inc_text", "type": "inclusion", "text": [ "women and men between 18 - 80 years of age\ntype 2 diabetes mellitus\nearly to moderate stage diabetic retinopathy (ETDRS: 20 (microaneurysms only) to 35 (microaneurysms/ hemorrhages and/or hard exsudates)) in one or both eyes\nstable HbA1c (± 0.5%) for at least 12 weeks\nantidiabetic treatment with either diet, metformin, DPP4, GLP1, pioglitazone, acarbose, or respective combinations\nHbA1c = 6.5 and = 10.0 %\nbody mass index < 46 kg/m2\noffice blood pressure = 150/95 mmHg (confirmed on a second day; 24h ambulatory blood pressure measurement (ABPM) is allowed to check accuracy of office values; inclusion with 24h mean blood pressure = 145/90 mm Hg is possible); patients with hypertension should be treated according to current treatment guidelines\nat least 6 weeks after surgical sterilization by bilateral tubal ligation or bilateral oophorectomy\nhysterectomy\n= 50 years and in postmenopausal state > 1 year\n< 50 years and in postmenopausal state > 1 year with serum follicle stimulating hormone (FSH) > 40 IU/l and serum estrogen < 30 ng/l or a negative estrogen test, both at screening or women of childbearing potential with a negative serum beta human chorionic gonadotropin (ß-hCG) pregnancy test at screening who agree to meet one of the following criteria from the time of screening, during the study and for a period of 4 days following the last administration of study medication:\ncorrect use of one of the following accepted contraception methods: hormonal contraceptives (combined oral contraceptives, implants, transdermal patches, hormonal vaginal devices or injections with prolonged release), intrauterine device (IUD/IUS) or a double barrier method, e.g. condom and occlusive cap (diaphragm or cervical/vault caps) with spermicide (foam, gel, film, cream or suppository)\ntrue abstinence (periodic abstinence and withdrawal are not acceptable methods of contraception)\nsexual relationship only with female partners\nsterile male partners\nsigned written informed consent and willingness to comply with treatment and follow-up procedures\ncapability of understanding the investigational nature, potential risks and benefits of the clinical trial\n" ], "offsets": [ [ 0, 2161 ] ] } ]

[ { "id": "NCT02985242_inc_T1", "type": "Person", "text": [ "women" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T2", "type": "Person", "text": [ "men" ], "offsets": [ [ 10, 13 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T3", "type": "Person", "text": [ "age" ], "offsets": [ [ 39, 42 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T4", "type": "Value", "text": [ "between 18 - 80 years" ], "offsets": [ [ 14, 35 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T5", "type": "Condition", "text": [ "type 2 diabetes mellitus" ], "offsets": [ [ 43, 67 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T6", "type": "Condition", "text": [ "diabetic retinopathy" ], "offsets": [ [ 92, 112 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T7", "type": "Qualifier", "text": [ "early" ], "offsets": [ [ 68, 73 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T8", "type": "Qualifier", "text": [ "moderate stage" ], "offsets": [ [ 77, 91 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T9", "type": "Scope", "text": [ "early to moderate stage" ], "offsets": [ [ 68, 91 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T10", "type": "Measurement", "text": [ "ETDRS" ], "offsets": [ [ 114, 119 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T11", "type": "Value", "text": [ "20" ], "offsets": [ [ 121, 123 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T12", "type": "Value", "text": [ "35" ], "offsets": [ [ 149, 151 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T13", "type": "Scope", "text": [ "20 (microaneurysms only) to 35" ], "offsets": [ [ 121, 151 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T14", "type": "Qualifier", "text": [ "eyes" ], "offsets": [ [ 220, 224 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T15", "type": "Measurement", "text": [ "HbA1c" ], "offsets": [ [ 232, 237 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T16", "type": "Value", "text": [ "± 0.5%" ], "offsets": [ [ 239, 245 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T17", "type": "Temporal", "text": [ "at least 12 weeks" ], "offsets": [ [ 251, 268 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T18", "type": "Procedure", "text": [ "antidiabetic treatment" ], "offsets": [ [ 269, 291 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T19", "type": "Observation", "text": [ "diet" ], "offsets": [ [ 304, 308 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T20", "type": "Drug", "text": [ "metformin" ], "offsets": [ [ 310, 319 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T21", "type": "Drug", "text": [ "DPP4" ], "offsets": [ [ 321, 325 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T22", "type": "Drug", "text": [ "GLP1" ], "offsets": [ [ 327, 331 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T23", "type": "Drug", "text": [ "pioglitazone" ], "offsets": [ [ 333, 345 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T24", "type": "Drug", "text": [ "acarbose" ], "offsets": [ [ 347, 355 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T25", "type": "Scope", "text": [ "diet, metformin, DPP4, GLP1, pioglitazone, acarbose" ], "offsets": [ [ 304, 355 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T26", "type": "Measurement", "text": [ "HbA1c" ], "offsets": [ [ 384, 389 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T27", "type": "Value", "text": [ "= 6.5 and = 10.0 %" ], "offsets": [ [ 390, 408 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T28", "type": "Person", "text": [ "body mass index" ], "offsets": [ [ 409, 424 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T29", "type": "Value", "text": [ "< 46 kg/m2" ], "offsets": [ [ 425, 435 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T30", "type": "Measurement", "text": [ "blood pressure" ], "offsets": [ [ 443, 457 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T31", "type": "Value", "text": [ "= 150/95 mmHg" ], "offsets": [ [ 458, 471 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T33", "type": "Procedure", "text": [ "surgical sterilization" ], "offsets": [ [ 774, 796 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T34", "type": "Procedure", "text": [ "bilateral tubal ligation" ], "offsets": [ [ 800, 824 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T35", "type": "Procedure", "text": [ "bilateral oophorectomy" ], "offsets": [ [ 828, 850 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T36", "type": "Scope", "text": [ "bilateral tubal ligation or bilateral oophorectomy" ], "offsets": [ [ 800, 850 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T37", "type": "Temporal", "text": [ "at least 6 weeks" ], "offsets": [ [ 751, 767 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T38", "type": "Procedure", "text": [ "hysterectomy" ], "offsets": [ [ 851, 863 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T39", "type": "Person", "text": [ "years" ], "offsets": [ [ 869, 874 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T40", "type": "Value", "text": [ "= 50" ], "offsets": [ [ 864, 868 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T41", "type": "Observation", "text": [ "postmenopausal state" ], "offsets": [ [ 882, 902 ] ], "normalized": [] }, { "id": "NCT02985242_inc_T42", "type": "Temporal", "text": [ "> 1 year" ], "offsets": [ [ 903, 911 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02985242_inc_R1", "type": "Has_value", "arg1_id": "NCT02985242_inc_T3", "arg2_id": "NCT02985242_inc_T4", "normalized": [] }, { "id": "NCT02985242_inc_R2", "type": "Has_scope", "arg1_id": "NCT02985242_inc_T6", "arg2_id": "NCT02985242_inc_T9", "normalized": [] }, { "id": "NCT02985242_inc_R3", "type": "Has_scope", "arg1_id": "NCT02985242_inc_T10", "arg2_id": "NCT02985242_inc_T13", "normalized": [] }, { "id": "NCT02985242_inc_R4", "type": "Has_value", "arg1_id": "NCT02985242_inc_T15", "arg2_id": "NCT02985242_inc_T16", "normalized": [] }, { "id": "NCT02985242_inc_R5", "type": "Has_temporal", "arg1_id": "NCT02985242_inc_T16", "arg2_id": "NCT02985242_inc_T17", "normalized": [] }, { "id": "NCT02985242_inc_R6", "type": "Subsumes", "arg1_id": "NCT02985242_inc_T18", "arg2_id": "NCT02985242_inc_T25", "normalized": [] }, { "id": "NCT02985242_inc_R7", "type": "Has_value", "arg1_id": "NCT02985242_inc_T26", "arg2_id": "NCT02985242_inc_T27", "normalized": [] }, { "id": "NCT02985242_inc_R8", "type": "Has_value", "arg1_id": "NCT02985242_inc_T28", "arg2_id": "NCT02985242_inc_T29", "normalized": [] }, { "id": "NCT02985242_inc_R9", "type": "Has_value", "arg1_id": "NCT02985242_inc_T30", "arg2_id": "NCT02985242_inc_T31", "normalized": [] }, { "id": "NCT02985242_inc_R10", "type": "Has_scope", "arg1_id": "NCT02985242_inc_T33", "arg2_id": "NCT02985242_inc_T36", "normalized": [] }, { "id": "NCT02985242_inc_R11", "type": "Has_temporal", "arg1_id": "NCT02985242_inc_T36", "arg2_id": "NCT02985242_inc_T37", "normalized": [] }, { "id": "NCT02985242_inc_R12", "type": "Has_temporal", "arg1_id": "NCT02985242_inc_T41", "arg2_id": "NCT02985242_inc_T42", "normalized": [] }, { "id": "NCT02985242_inc_R13", "type": "Has_value", "arg1_id": "NCT02985242_inc_T39", "arg2_id": "NCT02985242_inc_T40", "normalized": [] } ]

[ { "id": "NCT02985710_exc_text", "type": "exclusion", "text": [ "Subjects with cognitive, psychiatric, or other problems that preclude informed consent. \nPatients with history of glucose intolerance or diabetes. \nPatient on chemotherapy \nPeople with any open or bleeding wounds at any sensor plate contact surface location \nPeople with any type of implantable device \nPeople with missing hand(s) and/or leg(s) \nPregnant women or women who are uncertain about a possible pregnancy \nPatients sensitive to chemicals used to induce sweating \nPatients with heat intolerance \nPatients with bleeding disorders \nPatients on current anticoagulant therapy \nPatients with keloids on the intended biopsy site \nPeople with hypersensitivity to local amide-type anesthetics \n \n" ], "offsets": [ [ 0, 706 ] ] } ]

[ { "id": "NCT02985710_exc_T1", "type": "Condition", "text": [ "cognitive", "problems" ], "offsets": [ [ 14, 23 ], [ 47, 55 ] ], "normalized": [] }, { "id": "NCT02985710_exc_T2", "type": "Condition", "text": [ "psychiatric", "problems" ], "offsets": [ [ 25, 36 ], [ 47, 55 ] ], "normalized": [] }, { "id": "NCT02985710_exc_T3", "type": "Condition", "text": [ "other problems that preclude informed consent" ], "offsets": [ [ 41, 86 ] ], "normalized": [] }, { "id": "NCT02985710_exc_T6", "type": "Condition", "text": [ "glucose intolerance" ], "offsets": [ [ 114, 133 ] ], "normalized": [] }, { "id": "NCT02985710_exc_T7", "type": "Condition", "text": [ "diabetes" ], "offsets": [ [ 137, 145 ] ], "normalized": [] }, { "id": "NCT02985710_exc_T8", "type": "Observation", "text": [ "history" ], "offsets": [ [ 103, 110 ] ], "normalized": [] }, { "id": "NCT02985710_exc_T9", "type": "Procedure", "text": [ "chemotherapy" ], "offsets": [ [ 159, 171 ] ], "normalized": [] }, { "id": "NCT02985710_exc_T10", "type": "Condition", "text": [ "bleeding wounds" ], "offsets": [ [ 197, 212 ] ], "normalized": [] }, { "id": "NCT02985710_exc_T11", "type": "Condition", "text": [ "open", "wounds" ], "offsets": [ [ 189, 193 ], [ 206, 212 ] ], "normalized": [] }, { "id": "NCT02985710_exc_T12", "type": "Qualifier", "text": [ "at any sensor plate contact surface location" ], "offsets": [ [ 213, 257 ] ], "normalized": [] }, { "id": "NCT02985710_exc_T13", "type": "Device", "text": [ "implantable device" ], "offsets": [ [ 283, 301 ] ], "normalized": [] }, { "id": "NCT02985710_exc_T14", "type": "Condition", "text": [ "missing hand" ], "offsets": [ [ 315, 327 ] ], "normalized": [] }, { "id": "NCT02985710_exc_T15", "type": "Condition", "text": [ "missing", "leg" ], "offsets": [ [ 315, 322 ], [ 338, 341 ] ], "normalized": [] }, { "id": "NCT02985710_exc_T16", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 346, 354 ] ], "normalized": [] }, { "id": "NCT02985710_exc_T17", "type": "Observation", "text": [ "possible pregnancy" ], "offsets": [ [ 396, 414 ] ], "normalized": [] }, { "id": "NCT02985710_exc_T19", "type": "Condition", "text": [ "sensitive to chemicals used to induce sweating" ], "offsets": [ [ 425, 471 ] ], "normalized": [] }, { "id": "NCT02985710_exc_T21", "type": "Condition", "text": [ "heat intolerance" ], "offsets": [ [ 487, 503 ] ], "normalized": [] }, { "id": "NCT02985710_exc_T22", "type": "Condition", "text": [ "bleeding disorders" ], "offsets": [ [ 519, 537 ] ], "normalized": [] }, { "id": "NCT02985710_exc_T23", "type": "Procedure", "text": [ "anticoagulant therapy" ], "offsets": [ [ 559, 580 ] ], "normalized": [] }, { "id": "NCT02985710_exc_T24", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 551, 558 ] ], "normalized": [] }, { "id": "NCT02985710_exc_T25", "type": "Condition", "text": [ "keloids" ], "offsets": [ [ 596, 603 ] ], "normalized": [] }, { "id": "NCT02985710_exc_T26", "type": "Qualifier", "text": [ "on the intended biopsy site" ], "offsets": [ [ 604, 631 ] ], "normalized": [] }, { "id": "NCT02985710_exc_T27", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 645, 661 ] ], "normalized": [] }, { "id": "NCT02985710_exc_T28", "type": "Drug", "text": [ "local amide-type anesthetics" ], "offsets": [ [ 665, 693 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02985710_exc_R1", "type": "Has_temporal", "arg1_id": "NCT02985710_exc_T6", "arg2_id": "NCT02985710_exc_T8", "normalized": [] }, { "id": "NCT02985710_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02985710_exc_T7", "arg2_id": "NCT02985710_exc_T8", "normalized": [] }, { "id": "NCT02985710_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02985710_exc_T11", "arg2_id": "NCT02985710_exc_T12", "normalized": [] }, { "id": "NCT02985710_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT02985710_exc_T10", "arg2_id": "NCT02985710_exc_T12", "normalized": [] }, { "id": "NCT02985710_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02985710_exc_T23", "arg2_id": "NCT02985710_exc_T24", "normalized": [] }, { "id": "NCT02985710_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02985710_exc_T25", "arg2_id": "NCT02985710_exc_T26", "normalized": [] }, { "id": "NCT02985710_exc_R7", "type": "AND", "arg1_id": "NCT02985710_exc_T27", "arg2_id": "NCT02985710_exc_T28", "normalized": [] } ]

[ { "id": "NCT02985710_inc_text", "type": "inclusion", "text": [ "Males and females with confirmed disease: Fabry (by GLA enzymes and/or DNA testing) naïve and on ERT, Mitochondrial diseases (electron transport chain and/or DNA testing) or connective tissue diseases (clinical criteria and/or DNA testing when available) \nConsenting adults (18 years and older) who agrees and consents to skin biopsy and QSART procedure \n" ], "offsets": [ [ 0, 355 ] ] } ]

[ { "id": "NCT02985710_inc_T1", "type": "Person", "text": [ "Males" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT02985710_inc_T2", "type": "Person", "text": [ "females" ], "offsets": [ [ 10, 17 ] ], "normalized": [] }, { "id": "NCT02985710_inc_T4", "type": "Qualifier", "text": [ "Fabry", "naïve" ], "offsets": [ [ 42, 47 ], [ 84, 89 ] ], "normalized": [] }, { "id": "NCT02985710_inc_T5", "type": "Procedure", "text": [ "ERT" ], "offsets": [ [ 97, 100 ] ], "normalized": [] }, { "id": "NCT02985710_inc_T6", "type": "Procedure", "text": [ "GLA enzymes" ], "offsets": [ [ 52, 63 ] ], "normalized": [] }, { "id": "NCT02985710_inc_T7", "type": "Procedure", "text": [ "DNA testing" ], "offsets": [ [ 71, 82 ] ], "normalized": [] }, { "id": "NCT02985710_inc_T8", "type": "Scope", "text": [ "GLA enzymes and/or DNA testing" ], "offsets": [ [ 52, 82 ] ], "normalized": [] }, { "id": "NCT02985710_inc_T9", "type": "Condition", "text": [ "confirmed disease" ], "offsets": [ [ 23, 40 ] ], "normalized": [] }, { "id": "NCT02985710_inc_T11", "type": "Condition", "text": [ "Mitochondrial diseases" ], "offsets": [ [ 102, 124 ] ], "normalized": [] }, { "id": "NCT02985710_inc_T12", "type": "Procedure", "text": [ "electron transport chain" ], "offsets": [ [ 126, 150 ] ], "normalized": [] }, { "id": "NCT02985710_inc_T13", "type": "Procedure", "text": [ "DNA testing" ], "offsets": [ [ 158, 169 ] ], "normalized": [] }, { "id": "NCT02985710_inc_T14", "type": "Scope", "text": [ "electron transport chain and/or DNA testing" ], "offsets": [ [ 126, 169 ] ], "normalized": [] }, { "id": "NCT02985710_inc_T15", "type": "Condition", "text": [ "connective tissue diseases" ], "offsets": [ [ 174, 200 ] ], "normalized": [] }, { "id": "NCT02985710_inc_T16", "type": "Procedure", "text": [ "DNA testing" ], "offsets": [ [ 227, 238 ] ], "normalized": [] }, { "id": "NCT02985710_inc_T17", "type": "Observation", "text": [ "clinical criteria" ], "offsets": [ [ 202, 219 ] ], "normalized": [] }, { "id": "NCT02985710_inc_T18", "type": "Scope", "text": [ "clinical criteria and/or DNA testing" ], "offsets": [ [ 202, 238 ] ], "normalized": [] }, { "id": "NCT02985710_inc_T20", "type": "Scope", "text": [ "Fabry (by GLA enzymes and/or DNA testing) naïve and on ERT" ], "offsets": [ [ 42, 100 ] ], "normalized": [] }, { "id": "NCT02985710_inc_T21", "type": "Scope", "text": [ "Fabry (by GLA enzymes and/or DNA testing) naïve and on ERT, Mitochondrial diseases (electron transport chain and/or DNA testing) or connective tissue diseases (clinical criteria and/or DNA testing when available)" ], "offsets": [ [ 42, 254 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02985710_inc_R1", "type": "Has_scope", "arg1_id": "NCT02985710_inc_T4", "arg2_id": "NCT02985710_inc_T8", "normalized": [] }, { "id": "NCT02985710_inc_R2", "type": "Has_scope", "arg1_id": "NCT02985710_inc_T11", "arg2_id": "NCT02985710_inc_T14", "normalized": [] }, { "id": "NCT02985710_inc_R3", "type": "Has_scope", "arg1_id": "NCT02985710_inc_T15", "arg2_id": "NCT02985710_inc_T18", "normalized": [] }, { "id": "NCT02985710_inc_R4", "type": "Subsumes", "arg1_id": "NCT02985710_inc_T9", "arg2_id": "NCT02985710_inc_T21", "normalized": [] } ]

[ { "id": "NCT02986659_exc_text", "type": "exclusion", "text": [ "eGFR <45\nType 2 diabetes (HbA1c>6.5) or type 1 diabetes\nAny tobacco or nicotine product use in the past year\nLow vitamin B12 Levels (< 300 pg/mL)\nSelf-reported severe difficulty or inability to walk 400m or climb 10 steps (from Q 2 and 19 on PAT-D)\nSelf-reported difficulty or inability to perform basic ADL functions (from Q 10, 13, 14, 16 on PAT-D)\nExcessive alcohol use (>14 drinks/week)\nCancer requiring treatment in past year (except skin)\nDementia - diagnosed and/or MoCA score <18\nParkinson's or other neurological disease\nChronic liver disease or cirrhosis\nEnd stage renal disease or on dialysis\nRheumatic conditions (Rheumatoid arthritis, lupus, and any other autoimmune disease the -PI deems them to be ineligible for)\nThyroid problems the PI deems them to be ineligible for\nGout\nInvolved in another interventional study\nHemoglobin <8 or diagnosed with anemia\nRecent unintentional weight change (+/- 10 lbs. in the last 12 months)\nBMI <18.5\nLikely to not follow the protocol\nPI deems unfit to participate\nAlready taking Metformin or any other drug intended to treat diabetes\n" ], "offsets": [ [ 0, 1085 ] ] } ]

[ { "id": "NCT02986659_exc_T1", "type": "Measurement", "text": [ "eGFR" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T2", "type": "Value", "text": [ "<45" ], "offsets": [ [ 5, 8 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T3", "type": "Condition", "text": [ "Type 2 diabetes" ], "offsets": [ [ 9, 24 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T4", "type": "Measurement", "text": [ "HbA1c" ], "offsets": [ [ 26, 31 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T5", "type": "Value", "text": [ ">6.5" ], "offsets": [ [ 31, 35 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T6", "type": "Condition", "text": [ "type 1 diabetes" ], "offsets": [ [ 40, 55 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T7", "type": "Observation", "text": [ "nicotine product use" ], "offsets": [ [ 71, 91 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T8", "type": "Observation", "text": [ "tobacco" ], "offsets": [ [ 60, 67 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T9", "type": "Scope", "text": [ "tobacco or nicotine product use" ], "offsets": [ [ 60, 91 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T10", "type": "Temporal", "text": [ "past year" ], "offsets": [ [ 99, 108 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T11", "type": "Measurement", "text": [ "vitamin B12 Levels" ], "offsets": [ [ 113, 131 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T12", "type": "Value", "text": [ "< 300 pg/mL" ], "offsets": [ [ 133, 144 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T15", "type": "Observation", "text": [ "alcohol use" ], "offsets": [ [ 361, 372 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T16", "type": "Multiplier", "text": [ ">14 drinks/week" ], "offsets": [ [ 374, 389 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T17", "type": "Condition", "text": [ "Cancer" ], "offsets": [ [ 391, 397 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T18", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 408, 417 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T19", "type": "Temporal", "text": [ "past year" ], "offsets": [ [ 421, 430 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T20", "type": "Condition", "text": [ "Dementia" ], "offsets": [ [ 445, 453 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T21", "type": "Measurement", "text": [ "MoCA score" ], "offsets": [ [ 473, 483 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T22", "type": "Value", "text": [ "<18" ], "offsets": [ [ 484, 487 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T23", "type": "Condition", "text": [ "Parkinson's" ], "offsets": [ [ 488, 499 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T24", "type": "Condition", "text": [ "neurological disease" ], "offsets": [ [ 509, 529 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T25", "type": "Condition", "text": [ "Chronic liver disease" ], "offsets": [ [ 530, 551 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T26", "type": "Condition", "text": [ "cirrhosis" ], "offsets": [ [ 555, 564 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T27", "type": "Condition", "text": [ "End stage renal disease" ], "offsets": [ [ 565, 588 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T28", "type": "Procedure", "text": [ "dialysis" ], "offsets": [ [ 595, 603 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T29", "type": "Condition", "text": [ "Rheumatic conditions" ], "offsets": [ [ 604, 624 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T30", "type": "Condition", "text": [ "Rheumatoid arthritis" ], "offsets": [ [ 626, 646 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T31", "type": "Condition", "text": [ "lupus" ], "offsets": [ [ 648, 653 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T32", "type": "Condition", "text": [ "autoimmune disease" ], "offsets": [ [ 669, 687 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T33", "type": "Scope", "text": [ "Rheumatoid arthritis, lupus, and any other autoimmune disease" ], "offsets": [ [ 626, 687 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T34", "type": "Condition", "text": [ "Thyroid problems" ], "offsets": [ [ 729, 745 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T35", "type": "Condition", "text": [ "Gout" ], "offsets": [ [ 785, 789 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T37", "type": "Measurement", "text": [ "Hemoglobin" ], "offsets": [ [ 831, 841 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T38", "type": "Value", "text": [ "<8" ], "offsets": [ [ 842, 844 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T39", "type": "Condition", "text": [ "anemia" ], "offsets": [ [ 863, 869 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T40", "type": "Measurement", "text": [ "weight" ], "offsets": [ [ 891, 897 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T41", "type": "Value", "text": [ "+/- 10 lbs." ], "offsets": [ [ 906, 917 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T42", "type": "Temporal", "text": [ "last 12 months" ], "offsets": [ [ 925, 939 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T43", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 941, 944 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T44", "type": "Value", "text": [ "<18.5" ], "offsets": [ [ 945, 950 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T47", "type": "Drug", "text": [ "Metformin" ], "offsets": [ [ 1030, 1039 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T48", "type": "Drug", "text": [ "drug" ], "offsets": [ [ 1053, 1057 ] ], "normalized": [] }, { "id": "NCT02986659_exc_T49", "type": "Qualifier", "text": [ "diabetes" ], "offsets": [ [ 1076, 1084 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02986659_exc_R1", "type": "AND", "arg1_id": "NCT02986659_exc_T3", "arg2_id": "NCT02986659_exc_T4", "normalized": [] }, { "id": "NCT02986659_exc_R2", "type": "Has_value", "arg1_id": "NCT02986659_exc_T4", "arg2_id": "NCT02986659_exc_T5", "normalized": [] }, { "id": "NCT02986659_exc_R3", "type": "Has_value", "arg1_id": "NCT02986659_exc_T1", "arg2_id": "NCT02986659_exc_T2", "normalized": [] }, { "id": "NCT02986659_exc_R4", "type": "Has_temporal", "arg1_id": "NCT02986659_exc_T9", "arg2_id": "NCT02986659_exc_T10", "normalized": [] }, { "id": "NCT02986659_exc_R5", "type": "Has_value", "arg1_id": "NCT02986659_exc_T11", "arg2_id": "NCT02986659_exc_T12", "normalized": [] }, { "id": "NCT02986659_exc_R6", "type": "Has_multiplier", "arg1_id": "NCT02986659_exc_T15", "arg2_id": "NCT02986659_exc_T16", "normalized": [] }, { "id": "NCT02986659_exc_R7", "type": "AND", "arg1_id": "NCT02986659_exc_T17", "arg2_id": "NCT02986659_exc_T18", "normalized": [] }, { "id": "NCT02986659_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02986659_exc_T17", "arg2_id": "NCT02986659_exc_T19", "normalized": [] }, { "id": "NCT02986659_exc_R9", "type": "Has_value", "arg1_id": "NCT02986659_exc_T21", "arg2_id": "NCT02986659_exc_T22", "normalized": [] }, { "id": "NCT02986659_exc_R10", "type": "AND", "arg1_id": "NCT02986659_exc_T20", "arg2_id": "NCT02986659_exc_T21", "normalized": [] }, { "id": "NCT02986659_exc_R11", "type": "Subsumes", "arg1_id": "NCT02986659_exc_T29", "arg2_id": "NCT02986659_exc_T33", "normalized": [] }, { "id": "NCT02986659_exc_R12", "type": "Has_value", "arg1_id": "NCT02986659_exc_T37", "arg2_id": "NCT02986659_exc_T38", "normalized": [] }, { "id": "NCT02986659_exc_R13", "type": "Has_value", "arg1_id": "NCT02986659_exc_T40", "arg2_id": "NCT02986659_exc_T41", "normalized": [] }, { "id": "NCT02986659_exc_R14", "type": "Has_temporal", "arg1_id": "NCT02986659_exc_T40", "arg2_id": "NCT02986659_exc_T42", "normalized": [] }, { "id": "NCT02986659_exc_R15", "type": "Has_value", "arg1_id": "NCT02986659_exc_T43", "arg2_id": "NCT02986659_exc_T44", "normalized": [] }, { "id": "NCT02986659_exc_R16", "type": "Has_qualifier", "arg1_id": "NCT02986659_exc_T48", "arg2_id": "NCT02986659_exc_T49", "normalized": [] } ]

[ { "id": "NCT02986659_inc_text", "type": "inclusion", "text": [ "Age 65 - 79\nHistory of coronary artery disease (MI/heart attack, stroke, heart failure, or peripheral artery disease)\nCancer, with no active treatment in the last year\nMCI (MoCA >18<26 -inclusive of 1 point if <12 years of education Group 2\nDecline physical function (walking speed < 1 m/s) Group 3 (Either or both)\nAbdominal obesity (>88cm women, >102cm men) AND hypertension (treated or resting blood pressure >140/90\nAbdominal obesity (>88cm women, >102cm men) AND hyperlipidemia (treated or fasting total cholesterol >240 English literacy Willing to provide informed consent\n" ], "offsets": [ [ 0, 579 ] ] } ]

[ { "id": "NCT02986659_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T2", "type": "Value", "text": [ "65 - 79" ], "offsets": [ [ 4, 11 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T3", "type": "Condition", "text": [ "coronary artery disease" ], "offsets": [ [ 23, 46 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T4", "type": "Observation", "text": [ "History" ], "offsets": [ [ 12, 19 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T5", "type": "Condition", "text": [ "heart attack" ], "offsets": [ [ 51, 63 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T6", "type": "Condition", "text": [ "MI" ], "offsets": [ [ 48, 50 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T7", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 65, 71 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T8", "type": "Condition", "text": [ "heart failure" ], "offsets": [ [ 73, 86 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T9", "type": "Condition", "text": [ "peripheral artery disease" ], "offsets": [ [ 91, 116 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T10", "type": "Scope", "text": [ "MI/heart attack, stroke, heart failure, or peripheral artery disease" ], "offsets": [ [ 48, 116 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T11", "type": "Condition", "text": [ "Cancer" ], "offsets": [ [ 118, 124 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T12", "type": "Negation", "text": [ "no" ], "offsets": [ [ 131, 133 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T14", "type": "Procedure", "text": [ "active treatment" ], "offsets": [ [ 134, 150 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T13", "type": "Temporal", "text": [ "in the last year" ], "offsets": [ [ 151, 167 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T15", "type": "Condition", "text": [ "MCI" ], "offsets": [ [ 168, 171 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T16", "type": "Measurement", "text": [ "MoCA" ], "offsets": [ [ 173, 177 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T17", "type": "Value", "text": [ ">18<26" ], "offsets": [ [ 178, 184 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T19", "type": "Scope", "text": [ "MoCA >18<26" ], "offsets": [ [ 173, 184 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T20", "type": "Condition", "text": [ "Decline physical function" ], "offsets": [ [ 241, 266 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T21", "type": "Measurement", "text": [ "walking speed" ], "offsets": [ [ 268, 281 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T22", "type": "Value", "text": [ "< 1 m/s" ], "offsets": [ [ 282, 289 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T24", "type": "Scope", "text": [ "walking speed < 1 m/s" ], "offsets": [ [ 268, 289 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T25", "type": "Condition", "text": [ "Abdominal obesity" ], "offsets": [ [ 316, 333 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T26", "type": "Value", "text": [ ">88cm" ], "offsets": [ [ 335, 340 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T27", "type": "Value", "text": [ ">102cm" ], "offsets": [ [ 348, 354 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T28", "type": "Measurement", "text": [ "Abdominal" ], "offsets": [ [ 316, 325 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T29", "type": "Person", "text": [ "women" ], "offsets": [ [ 341, 346 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T30", "type": "Person", "text": [ "men" ], "offsets": [ [ 355, 358 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T31", "type": "Scope", "text": [ ">88cm women, >102cm men" ], "offsets": [ [ 335, 358 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T32", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 364, 376 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T33", "type": "Procedure", "text": [ "treated" ], "offsets": [ [ 378, 385 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T34", "type": "Measurement", "text": [ "resting blood pressure" ], "offsets": [ [ 389, 411 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T35", "type": "Value", "text": [ ">140/90" ], "offsets": [ [ 412, 419 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T36", "type": "Scope", "text": [ "treated or resting blood pressure >140/90" ], "offsets": [ [ 378, 419 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T37", "type": "Condition", "text": [ "Abdominal obesity" ], "offsets": [ [ 420, 437 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T38", "type": "Value", "text": [ ">88cm" ], "offsets": [ [ 439, 444 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T39", "type": "Value", "text": [ ">102cm" ], "offsets": [ [ 452, 458 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T40", "type": "Person", "text": [ "women" ], "offsets": [ [ 445, 450 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T41", "type": "Person", "text": [ "men" ], "offsets": [ [ 459, 462 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T42", "type": "Scope", "text": [ ">88cm women, >102cm men" ], "offsets": [ [ 439, 462 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T43", "type": "Condition", "text": [ "hyperlipidemia" ], "offsets": [ [ 468, 482 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T44", "type": "Procedure", "text": [ "treated" ], "offsets": [ [ 484, 491 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T45", "type": "Measurement", "text": [ "fasting total cholesterol" ], "offsets": [ [ 495, 520 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T46", "type": "Value", "text": [ ">240" ], "offsets": [ [ 521, 525 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T47", "type": "Observation", "text": [ "English literacy" ], "offsets": [ [ 526, 542 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T48", "type": "Observation", "text": [ "provide informed consent" ], "offsets": [ [ 554, 578 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T49", "type": "Mood", "text": [ "Willing to" ], "offsets": [ [ 543, 553 ] ], "normalized": [] }, { "id": "NCT02986659_inc_T50", "type": "Scope", "text": [ "treated or fasting total cholesterol >240" ], "offsets": [ [ 484, 525 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02986659_inc_R1", "type": "Has_value", "arg1_id": "NCT02986659_inc_T1", "arg2_id": "NCT02986659_inc_T2", "normalized": [] }, { "id": "NCT02986659_inc_R2", "type": "Has_temporal", "arg1_id": "NCT02986659_inc_T3", "arg2_id": "NCT02986659_inc_T4", "normalized": [] }, { "id": "NCT02986659_inc_R3", "type": "Subsumes", "arg1_id": "NCT02986659_inc_T3", "arg2_id": "NCT02986659_inc_T10", "normalized": [] }, { "id": "NCT02986659_inc_R4", "type": "Has_temporal", "arg1_id": "NCT02986659_inc_T14", "arg2_id": "NCT02986659_inc_T13", "normalized": [] }, { "id": "NCT02986659_inc_R5", "type": "Has_negation", "arg1_id": "NCT02986659_inc_T14", "arg2_id": "NCT02986659_inc_T12", "normalized": [] }, { "id": "NCT02986659_inc_R6", "type": "AND", "arg1_id": "NCT02986659_inc_T11", "arg2_id": "NCT02986659_inc_T14", "normalized": [] }, { "id": "NCT02986659_inc_R7", "type": "Has_value", "arg1_id": "NCT02986659_inc_T16", "arg2_id": "NCT02986659_inc_T17", "normalized": [] }, { "id": "NCT02986659_inc_R8", "type": "Subsumes", "arg1_id": "NCT02986659_inc_T15", "arg2_id": "NCT02986659_inc_T19", "normalized": [] }, { "id": "NCT02986659_inc_R9", "type": "Has_value", "arg1_id": "NCT02986659_inc_T21", "arg2_id": "NCT02986659_inc_T22", "normalized": [] }, { "id": "NCT02986659_inc_R10", "type": "Subsumes", "arg1_id": "NCT02986659_inc_T20", "arg2_id": "NCT02986659_inc_T24", "normalized": [] }, { "id": "NCT02986659_inc_R11", "type": "Has_value", "arg1_id": "NCT02986659_inc_T29", "arg2_id": "NCT02986659_inc_T26", "normalized": [] }, { "id": "NCT02986659_inc_R12", "type": "Has_value", "arg1_id": "NCT02986659_inc_T30", "arg2_id": "NCT02986659_inc_T27", "normalized": [] }, { "id": "NCT02986659_inc_R13", "type": "Has_scope", "arg1_id": "NCT02986659_inc_T28", "arg2_id": "NCT02986659_inc_T31", "normalized": [] }, { "id": "NCT02986659_inc_R14", "type": "Has_value", "arg1_id": "NCT02986659_inc_T34", "arg2_id": "NCT02986659_inc_T35", "normalized": [] }, { "id": "NCT02986659_inc_R15", "type": "Has_scope", "arg1_id": "NCT02986659_inc_T32", "arg2_id": "NCT02986659_inc_T36", "normalized": [] }, { "id": "NCT02986659_inc_R16", "type": "Has_value", "arg1_id": "NCT02986659_inc_T40", "arg2_id": "NCT02986659_inc_T38", "normalized": [] }, { "id": "NCT02986659_inc_R17", "type": "Has_value", "arg1_id": "NCT02986659_inc_T41", "arg2_id": "NCT02986659_inc_T39", "normalized": [] }, { "id": "NCT02986659_inc_R18", "type": "Has_scope", "arg1_id": "NCT02986659_inc_T37", "arg2_id": "NCT02986659_inc_T42", "normalized": [] }, { "id": "NCT02986659_inc_R19", "type": "Has_value", "arg1_id": "NCT02986659_inc_T45", "arg2_id": "NCT02986659_inc_T46", "normalized": [] }, { "id": "NCT02986659_inc_R20", "type": "Has_mood", "arg1_id": "NCT02986659_inc_T48", "arg2_id": "NCT02986659_inc_T49", "normalized": [] }, { "id": "NCT02986659_inc_R21", "type": "Subsumes", "arg1_id": "NCT02986659_inc_T43", "arg2_id": "NCT02986659_inc_T50", "normalized": [] } ]

[ { "id": "NCT02990403_exc_text", "type": "exclusion", "text": [ "having experienced severe allergies, trauma history and/or operation history within 3 months.\nwith a history of mental illness and/or family history of mental illness limb disabled.\ntaking medicine within one month.\nsuffering major events or having mood swings.\nhaving internal and surgical disease(after having variety of physical examination such as electrocardiogram/hepatic and renal function/blood routine and urine routine)\nchromosome aberrations in anyone of the couple.\npatients who have drugs contraindications\n" ], "offsets": [ [ 0, 520 ] ] } ]

[ { "id": "NCT02990403_exc_T1", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 19, 25 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T2", "type": "Condition", "text": [ "allergies" ], "offsets": [ [ 26, 35 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T3", "type": "Condition", "text": [ "trauma" ], "offsets": [ [ 37, 43 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T4", "type": "Observation", "text": [ "history" ], "offsets": [ [ 44, 51 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T5", "type": "Procedure", "text": [ "operation" ], "offsets": [ [ 59, 68 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T6", "type": "Observation", "text": [ "history" ], "offsets": [ [ 69, 76 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T7", "type": "Temporal", "text": [ "within 3 months" ], "offsets": [ [ 77, 92 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T8", "type": "Scope", "text": [ "severe allergies, trauma history and/or operation history" ], "offsets": [ [ 19, 76 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T9", "type": "Condition", "text": [ "mental illness" ], "offsets": [ [ 112, 126 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T10", "type": "Observation", "text": [ "history" ], "offsets": [ [ 101, 108 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T11", "type": "Observation", "text": [ "family history" ], "offsets": [ [ 134, 148 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T12", "type": "Condition", "text": [ "mental illness" ], "offsets": [ [ 152, 166 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T13", "type": "Qualifier", "text": [ "limb disabled" ], "offsets": [ [ 167, 180 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T14", "type": "Drug", "text": [ "medicine" ], "offsets": [ [ 189, 197 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T15", "type": "Qualifier", "text": [ "within one month" ], "offsets": [ [ 198, 214 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T16", "type": "Condition", "text": [ "major events" ], "offsets": [ [ 226, 238 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T17", "type": "Condition", "text": [ "mood swings" ], "offsets": [ [ 249, 260 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T18", "type": "Condition", "text": [ "surgical disease" ], "offsets": [ [ 282, 298 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T19", "type": "Procedure", "text": [ "surgical" ], "offsets": [ [ 282, 290 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T20", "type": "Condition", "text": [ "rnal and", "ase(aft" ], "offsets": [ [ 273, 281 ], [ 295, 302 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T21", "type": "Procedure", "text": [ "physical examination" ], "offsets": [ [ 323, 343 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T22", "type": "Procedure", "text": [ "electrocardiogram" ], "offsets": [ [ 352, 369 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T23", "type": "Procedure", "text": [ "tic and", "tion/blo" ], "offsets": [ [ 374, 381 ], [ 392, 400 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T24", "type": "Procedure", "text": [ "renal function" ], "offsets": [ [ 382, 396 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T25", "type": "Procedure", "text": [ "blood routine" ], "offsets": [ [ 397, 410 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T26", "type": "Procedure", "text": [ "urine routine" ], "offsets": [ [ 415, 428 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T27", "type": "Temporal", "text": [ "after having variety of physical examination such as electrocardiogram/hepatic and renal function/blood routine and urine routine" ], "offsets": [ [ 299, 428 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T28", "type": "Reference_point", "text": [ "having variety of physical examination such as electrocardiogram/hepatic and renal function/blood routine and urine routine" ], "offsets": [ [ 305, 428 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T29", "type": "Scope", "text": [ "physical examination such as electrocardiogram/hepatic and renal function/blood routine and urine routine" ], "offsets": [ [ 323, 428 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T30", "type": "Scope", "text": [ "internal and surgical disease" ], "offsets": [ [ 269, 298 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T31", "type": "Condition", "text": [ "chromosome aberrations" ], "offsets": [ [ 430, 452 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T32", "type": "Observation", "text": [ "anyone of the couple" ], "offsets": [ [ 456, 476 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T33", "type": "Qualifier", "text": [ "anyone of the couple" ], "offsets": [ [ 456, 476 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T34", "type": "Drug", "text": [ "drugs" ], "offsets": [ [ 496, 501 ] ], "normalized": [] }, { "id": "NCT02990403_exc_T35", "type": "Condition", "text": [ "contraindications" ], "offsets": [ [ 502, 519 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02990403_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02990403_exc_T2", "arg2_id": "NCT02990403_exc_T1", "normalized": [] }, { "id": "NCT02990403_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02990403_exc_T3", "arg2_id": "NCT02990403_exc_T4", "normalized": [] }, { "id": "NCT02990403_exc_R3", "type": "Has_temporal", "arg1_id": "NCT02990403_exc_T5", "arg2_id": "NCT02990403_exc_T6", "normalized": [] }, { "id": "NCT02990403_exc_R4", "type": "Has_temporal", "arg1_id": "NCT02990403_exc_T8", "arg2_id": "NCT02990403_exc_T7", "normalized": [] }, { "id": "NCT02990403_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02990403_exc_T9", "arg2_id": "NCT02990403_exc_T10", "normalized": [] }, { "id": "NCT02990403_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT02990403_exc_T12", "arg2_id": "NCT02990403_exc_T13", "normalized": [] }, { "id": "NCT02990403_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT02990403_exc_T9", "arg2_id": "NCT02990403_exc_T13", "normalized": [] }, { "id": "NCT02990403_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT02990403_exc_T14", "arg2_id": "NCT02990403_exc_T15", "normalized": [] }, { "id": "NCT02990403_exc_R12", "type": "Has_index", "arg1_id": "NCT02990403_exc_T27", "arg2_id": "NCT02990403_exc_T28", "normalized": [] }, { "id": "NCT02990403_exc_R13", "type": "Has_temporal", "arg1_id": "NCT02990403_exc_T30", "arg2_id": "NCT02990403_exc_T27", "normalized": [] }, { "id": "NCT02990403_exc_R16", "type": "AND", "arg1_id": "NCT02990403_exc_T35", "arg2_id": "NCT02990403_exc_T34", "normalized": [] } ]

[ { "id": "NCT02990403_inc_text", "type": "inclusion", "text": [ "Woman who had 2 miscarriage before 12(th) week of gestation.The patient who is diagnosed as thrombophilia with recurrent pregnancy loss. Signed consent form.\n" ], "offsets": [ [ 0, 158 ] ] } ]

[ { "id": "NCT02990403_inc_T1", "type": "Person", "text": [ "Woman" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT02990403_inc_T2", "type": "Multiplier", "text": [ "2" ], "offsets": [ [ 14, 15 ] ], "normalized": [] }, { "id": "NCT02990403_inc_T3", "type": "Condition", "text": [ "miscarriage" ], "offsets": [ [ 16, 27 ] ], "normalized": [] }, { "id": "NCT02990403_inc_T4", "type": "Qualifier", "text": [ "before 12(th) week of gestation" ], "offsets": [ [ 28, 59 ] ], "normalized": [] }, { "id": "NCT02990403_inc_T5", "type": "Temporal", "text": [ "before 12(th) week of gestation" ], "offsets": [ [ 28, 59 ] ], "normalized": [] }, { "id": "NCT02990403_inc_T6", "type": "Reference_point", "text": [ "12(th) week of gestation" ], "offsets": [ [ 35, 59 ] ], "normalized": [] }, { "id": "NCT02990403_inc_T7", "type": "Condition", "text": [ "thrombophilia" ], "offsets": [ [ 92, 105 ] ], "normalized": [] }, { "id": "NCT02990403_inc_T8", "type": "Multiplier", "text": [ "recurrent" ], "offsets": [ [ 111, 120 ] ], "normalized": [] }, { "id": "NCT02990403_inc_T9", "type": "Condition", "text": [ "pregnancy loss" ], "offsets": [ [ 121, 135 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02990403_inc_R1", "type": "Has_index", "arg1_id": "NCT02990403_inc_T5", "arg2_id": "NCT02990403_inc_T6", "normalized": [] }, { "id": "NCT02990403_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT02990403_inc_T3", "arg2_id": "NCT02990403_inc_T4", "normalized": [] }, { "id": "NCT02990403_inc_R4", "type": "Has_multiplier", "arg1_id": "NCT02990403_inc_T3", "arg2_id": "NCT02990403_inc_T2", "normalized": [] }, { "id": "NCT02990403_inc_R5", "type": "Has_multiplier", "arg1_id": "NCT02990403_inc_T9", "arg2_id": "NCT02990403_inc_T8", "normalized": [] }, { "id": "NCT02990403_inc_R6", "type": "AND", "arg1_id": "NCT02990403_inc_T7", "arg2_id": "NCT02990403_inc_T9", "normalized": [] } ]

[ { "id": "NCT02992028_exc_text", "type": "exclusion", "text": [ "age <45 or >80\nallergies to medications used in the study\nhistory of renal diseases, a coagulation abnormality, a hepatic disease, or drug abuse\ndefinite radiographic evidence of osteoarthritis of the glenohumeral joint\ninflammatory arthritis including rheumatoid arthritis\na history of acute trauma\nsystemic conditions associated with chronic pain\na history of infection\nan inability to understand the questionnaires\n" ], "offsets": [ [ 0, 418 ] ] } ]

[ { "id": "NCT02992028_exc_T1", "type": "Person", "text": [ "age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T2", "type": "Value", "text": [ "<45 or >80" ], "offsets": [ [ 4, 14 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T3", "type": "Condition", "text": [ "allergies" ], "offsets": [ [ 15, 24 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T4", "type": "Drug", "text": [ "medications" ], "offsets": [ [ 28, 39 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T5", "type": "Qualifier", "text": [ "used in the study" ], "offsets": [ [ 40, 57 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T6", "type": "Observation", "text": [ "history" ], "offsets": [ [ 58, 65 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T7", "type": "Condition", "text": [ "renal diseases" ], "offsets": [ [ 69, 83 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T8", "type": "Condition", "text": [ "coagulation abnormality" ], "offsets": [ [ 87, 110 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T9", "type": "Condition", "text": [ "hepatic disease" ], "offsets": [ [ 114, 129 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T10", "type": "Condition", "text": [ "drug abuse" ], "offsets": [ [ 134, 144 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T11", "type": "Scope", "text": [ "renal diseases, a coagulation abnormality, a hepatic disease, or drug abuse" ], "offsets": [ [ 69, 144 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T12", "type": "Mood", "text": [ "radiographic evidence" ], "offsets": [ [ 154, 175 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T13", "type": "Condition", "text": [ "osteoarthritis" ], "offsets": [ [ 179, 193 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T14", "type": "Qualifier", "text": [ "glenohumeral joint" ], "offsets": [ [ 201, 219 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T15", "type": "Procedure", "text": [ "radiographic" ], "offsets": [ [ 154, 166 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T16", "type": "Qualifier", "text": [ "definite" ], "offsets": [ [ 145, 153 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T17", "type": "Condition", "text": [ "inflammatory arthritis" ], "offsets": [ [ 220, 242 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T18", "type": "Condition", "text": [ "rheumatoid arthritis" ], "offsets": [ [ 253, 273 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T19", "type": "Condition", "text": [ "acute trauma" ], "offsets": [ [ 287, 299 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T20", "type": "Observation", "text": [ "history" ], "offsets": [ [ 276, 283 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T21", "type": "Condition", "text": [ "systemic conditions" ], "offsets": [ [ 300, 319 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T22", "type": "Qualifier", "text": [ "associated with chronic pain" ], "offsets": [ [ 320, 348 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T23", "type": "Condition", "text": [ "chronic pain" ], "offsets": [ [ 336, 348 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T24", "type": "Observation", "text": [ "history" ], "offsets": [ [ 351, 358 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T25", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 362, 371 ] ], "normalized": [] }, { "id": "NCT02992028_exc_T26", "type": "Observation", "text": [ "inability to understand the questionnaires" ], "offsets": [ [ 375, 417 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02992028_exc_R1", "type": "Has_value", "arg1_id": "NCT02992028_exc_T1", "arg2_id": "NCT02992028_exc_T2", "normalized": [] }, { "id": "NCT02992028_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02992028_exc_T4", "arg2_id": "NCT02992028_exc_T5", "normalized": [] }, { "id": "NCT02992028_exc_R3", "type": "AND", "arg1_id": "NCT02992028_exc_T3", "arg2_id": "NCT02992028_exc_T4", "normalized": [] }, { "id": "NCT02992028_exc_R4", "type": "Has_temporal", "arg1_id": "NCT02992028_exc_T11", "arg2_id": "NCT02992028_exc_T6", "normalized": [] }, { "id": "NCT02992028_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02992028_exc_T13", "arg2_id": "NCT02992028_exc_T14", "normalized": [] }, { "id": "NCT02992028_exc_R7", "type": "Has_mood", "arg1_id": "NCT02992028_exc_T13", "arg2_id": "NCT02992028_exc_T12", "normalized": [] }, { "id": "NCT02992028_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT02992028_exc_T12", "arg2_id": "NCT02992028_exc_T16", "normalized": [] }, { "id": "NCT02992028_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT02992028_exc_T21", "arg2_id": "NCT02992028_exc_T22", "normalized": [] }, { "id": "NCT02992028_exc_R11", "type": "Has_temporal", "arg1_id": "NCT02992028_exc_T25", "arg2_id": "NCT02992028_exc_T24", "normalized": [] } ]

[ { "id": "NCT02992028_inc_text", "type": "inclusion", "text": [ "Rotator cuff tear patients undergoing arthroscopic rotator cuff tear\n" ], "offsets": [ [ 0, 69 ] ] } ]

[ { "id": "NCT02992028_inc_T1", "type": "Condition", "text": [ "Rotator cuff tear" ], "offsets": [ [ 0, 17 ] ], "normalized": [] }, { "id": "NCT02992028_inc_T2", "type": "Procedure", "text": [ "arthroscopic rotator cuff tear" ], "offsets": [ [ 38, 68 ] ], "normalized": [] } ]

[]

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[]

[ { "id": "NCT02992938_exc_text", "type": "exclusion", "text": [ "Patients ASA III y IV\nChronic pain history\nDrug and alcohol abuse\nChronic use of opioid and sedatives\nNeuropsychiatric illness\nNSAID and other analgesics used the 48 hours previous to the surgery\nCMI > 30\n" ], "offsets": [ [ 0, 205 ] ] } ]

[ { "id": "NCT02992938_exc_T1", "type": "Measurement", "text": [ "ASA" ], "offsets": [ [ 9, 12 ] ], "normalized": [] }, { "id": "NCT02992938_exc_T2", "type": "Value", "text": [ "III y IV" ], "offsets": [ [ 13, 21 ] ], "normalized": [] }, { "id": "NCT02992938_exc_T3", "type": "Condition", "text": [ "Chronic pain" ], "offsets": [ [ 22, 34 ] ], "normalized": [] }, { "id": "NCT02992938_exc_T4", "type": "Condition", "text": [ "ug a", "use\nC" ], "offsets": [ [ 45, 49 ], [ 62, 67 ] ], "normalized": [] }, { "id": "NCT02992938_exc_T5", "type": "Condition", "text": [ "alcohol abuse" ], "offsets": [ [ 52, 65 ] ], "normalized": [] }, { "id": "NCT02992938_exc_T6", "type": "Drug", "text": [ "opioid" ], "offsets": [ [ 81, 87 ] ], "normalized": [] }, { "id": "NCT02992938_exc_T7", "type": "Drug", "text": [ "sedatives" ], "offsets": [ [ 92, 101 ] ], "normalized": [] }, { "id": "NCT02992938_exc_T8", "type": "Multiplier", "text": [ "Chronic use" ], "offsets": [ [ 66, 77 ] ], "normalized": [] }, { "id": "NCT02992938_exc_T9", "type": "Scope", "text": [ "opioid and sedatives" ], "offsets": [ [ 81, 101 ] ], "normalized": [] }, { "id": "NCT02992938_exc_T10", "type": "Condition", "text": [ "Neuropsychiatric illness" ], "offsets": [ [ 102, 126 ] ], "normalized": [] }, { "id": "NCT02992938_exc_T11", "type": "Drug", "text": [ "NSAID" ], "offsets": [ [ 127, 132 ] ], "normalized": [] }, { "id": "NCT02992938_exc_T12", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 137, 142 ] ], "normalized": [] }, { "id": "NCT02992938_exc_T13", "type": "Drug", "text": [ "analgesics" ], "offsets": [ [ 143, 153 ] ], "normalized": [] }, { "id": "NCT02992938_exc_T14", "type": "Temporal", "text": [ "48 hours previous to the surgery" ], "offsets": [ [ 163, 195 ] ], "normalized": [] }, { "id": "NCT02992938_exc_T15", "type": "Reference_point", "text": [ "the surgery" ], "offsets": [ [ 184, 195 ] ], "normalized": [] }, { "id": "NCT02992938_exc_T16", "type": "Scope", "text": [ "NSAID and other analgesics" ], "offsets": [ [ 127, 153 ] ], "normalized": [] }, { "id": "NCT02992938_exc_T17", "type": "Measurement", "text": [ "CMI" ], "offsets": [ [ 196, 199 ] ], "normalized": [] }, { "id": "NCT02992938_exc_T18", "type": "Value", "text": [ "> 3" ], "offsets": [ [ 200, 203 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02992938_exc_R1", "type": "Has_value", "arg1_id": "NCT02992938_exc_T1", "arg2_id": "NCT02992938_exc_T2", "normalized": [] }, { "id": "NCT02992938_exc_R2", "type": "Has_multiplier", "arg1_id": "NCT02992938_exc_T9", "arg2_id": "NCT02992938_exc_T8", "normalized": [] }, { "id": "NCT02992938_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02992938_exc_T13", "arg2_id": "NCT02992938_exc_T12", "normalized": [] }, { "id": "NCT02992938_exc_R4", "type": "Has_index", "arg1_id": "NCT02992938_exc_T14", "arg2_id": "NCT02992938_exc_T15", "normalized": [] }, { "id": "NCT02992938_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02992938_exc_T16", "arg2_id": "NCT02992938_exc_T14", "normalized": [] }, { "id": "NCT02992938_exc_R6", "type": "Has_value", "arg1_id": "NCT02992938_exc_T17", "arg2_id": "NCT02992938_exc_T18", "normalized": [] } ]

[ { "id": "NCT02992938_inc_text", "type": "inclusion", "text": [ "Patients scheduled for thyroidectomy with general anesthesia in the University of Chile Clinical Hospital\n" ], "offsets": [ [ 0, 106 ] ] } ]

[ { "id": "NCT02992938_inc_T1", "type": "Mood", "text": [ "scheduled for" ], "offsets": [ [ 9, 22 ] ], "normalized": [] }, { "id": "NCT02992938_inc_T2", "type": "Procedure", "text": [ "thyroidectomy" ], "offsets": [ [ 23, 36 ] ], "normalized": [] }, { "id": "NCT02992938_inc_T3", "type": "Procedure", "text": [ "general anesthesia" ], "offsets": [ [ 42, 60 ] ], "normalized": [] }, { "id": "NCT02992938_inc_T4", "type": "Visit", "text": [ "University of Chile Clinical Hospita" ], "offsets": [ [ 68, 104 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02992938_inc_R1", "type": "AND", "arg1_id": "NCT02992938_inc_T2", "arg2_id": "NCT02992938_inc_T3", "normalized": [] }, { "id": "NCT02992938_inc_R2", "type": "Has_mood", "arg1_id": "NCT02992938_inc_T2", "arg2_id": "NCT02992938_inc_T1", "normalized": [] }, { "id": "NCT02992938_inc_R3", "type": "AND", "arg1_id": "NCT02992938_inc_T2", "arg2_id": "NCT02992938_inc_T4", "normalized": [] } ]

[ { "id": "NCT02995291_exc_text", "type": "exclusion", "text": [ "contra-indications for regular dental treatment\nmedical history that contraindicates the use of epinephrine\nparticipant taken an opioid or an opioid like analgesic within 24 hours\npregnant\n" ], "offsets": [ [ 0, 189 ] ] } ]

[ { "id": "NCT02995291_exc_T1", "type": "Condition", "text": [ "contra-indications" ], "offsets": [ [ 0, 18 ] ], "normalized": [] }, { "id": "NCT02995291_exc_T2", "type": "Procedure", "text": [ "regular dental treatment" ], "offsets": [ [ 23, 47 ] ], "normalized": [] }, { "id": "NCT02995291_exc_T3", "type": "Observation", "text": [ "medical history" ], "offsets": [ [ 48, 63 ] ], "normalized": [] }, { "id": "NCT02995291_exc_T4", "type": "Condition", "text": [ "contraindicates" ], "offsets": [ [ 69, 84 ] ], "normalized": [] }, { "id": "NCT02995291_exc_T5", "type": "Drug", "text": [ "epinephrine" ], "offsets": [ [ 96, 107 ] ], "normalized": [] }, { "id": "NCT02995291_exc_T6", "type": "Drug", "text": [ "opioid" ], "offsets": [ [ 129, 135 ] ], "normalized": [] }, { "id": "NCT02995291_exc_T7", "type": "Drug", "text": [ "opioid like analgesic" ], "offsets": [ [ 142, 163 ] ], "normalized": [] }, { "id": "NCT02995291_exc_T8", "type": "Temporal", "text": [ "within 24 hours" ], "offsets": [ [ 164, 179 ] ], "normalized": [] }, { "id": "NCT02995291_exc_T9", "type": "Scope", "text": [ "opioid or an opioid like analgesic" ], "offsets": [ [ 129, 163 ] ], "normalized": [] }, { "id": "NCT02995291_exc_T10", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 180, 188 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02995291_exc_R1", "type": "AND", "arg1_id": "NCT02995291_exc_T1", "arg2_id": "NCT02995291_exc_T2", "normalized": [] }, { "id": "NCT02995291_exc_R2", "type": "AND", "arg1_id": "NCT02995291_exc_T4", "arg2_id": "NCT02995291_exc_T5", "normalized": [] }, { "id": "NCT02995291_exc_R3", "type": "Has_temporal", "arg1_id": "NCT02995291_exc_T4", "arg2_id": "NCT02995291_exc_T3", "normalized": [] }, { "id": "NCT02995291_exc_R4", "type": "Has_temporal", "arg1_id": "NCT02995291_exc_T9", "arg2_id": "NCT02995291_exc_T8", "normalized": [] } ]

[ { "id": "NCT02995291_inc_text", "type": "inclusion", "text": [ "18 years of age or older\ncapable of providing informed consent\n" ], "offsets": [ [ 0, 63 ] ] } ]

[ { "id": "NCT02995291_inc_T1", "type": "Person", "text": [ "age" ], "offsets": [ [ 12, 15 ] ], "normalized": [] }, { "id": "NCT02995291_inc_T2", "type": "Value", "text": [ "18 years of", "or older" ], "offsets": [ [ 0, 11 ], [ 16, 24 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02995291_inc_R1", "type": "Has_value", "arg1_id": "NCT02995291_inc_T1", "arg2_id": "NCT02995291_inc_T2", "normalized": [] } ]

[ { "id": "NCT02996916_exc_text", "type": "exclusion", "text": [ "Secondary hypertension or malignant hypertension\nDiabetes mellitus\nHistory or evidence of a stroke\nHepatic or hematologic abnormality\nMild Cognitive Impairment or Dementia\nSerum potassium level = 5.5 mEq/L\nSerum creatinine level = 3.0 mg/dL\nAcute or chronic disease\nAllergy to any drugs\nPregnancy\n" ], "offsets": [ [ 0, 297 ] ] } ]

[ { "id": "NCT02996916_exc_T1", "type": "Condition", "text": [ "Secondary hypertension" ], "offsets": [ [ 0, 22 ] ], "normalized": [] }, { "id": "NCT02996916_exc_T2", "type": "Condition", "text": [ "malignant hypertension" ], "offsets": [ [ 26, 48 ] ], "normalized": [] }, { "id": "NCT02996916_exc_T3", "type": "Condition", "text": [ "Diabetes mellitus" ], "offsets": [ [ 49, 66 ] ], "normalized": [] }, { "id": "NCT02996916_exc_T4", "type": "Observation", "text": [ "History" ], "offsets": [ [ 67, 74 ] ], "normalized": [] }, { "id": "NCT02996916_exc_T5", "type": "Mood", "text": [ "evidence" ], "offsets": [ [ 78, 86 ] ], "normalized": [] }, { "id": "NCT02996916_exc_T6", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 92, 98 ] ], "normalized": [] }, { "id": "NCT02996916_exc_T7", "type": "Scope", "text": [ "History or evidence" ], "offsets": [ [ 67, 86 ] ], "normalized": [] }, { "id": "NCT02996916_exc_T8", "type": "Condition", "text": [ "atic or", "ormality\nMi" ], "offsets": [ [ 102, 109 ], [ 125, 136 ] ], "normalized": [] }, { "id": "NCT02996916_exc_T9", "type": "Condition", "text": [ "hematologic abnormality" ], "offsets": [ [ 110, 133 ] ], "normalized": [] }, { "id": "NCT02996916_exc_T10", "type": "Condition", "text": [ "Mild Cognitive Impairment" ], "offsets": [ [ 134, 159 ] ], "normalized": [] }, { "id": "NCT02996916_exc_T11", "type": "Condition", "text": [ "Dementia" ], "offsets": [ [ 163, 171 ] ], "normalized": [] }, { "id": "NCT02996916_exc_T12", "type": "Measurement", "text": [ "Serum potassium level" ], "offsets": [ [ 172, 193 ] ], "normalized": [] }, { "id": "NCT02996916_exc_T13", "type": "Value", "text": [ "= 5.5 mEq/L" ], "offsets": [ [ 194, 205 ] ], "normalized": [] }, { "id": "NCT02996916_exc_T14", "type": "Measurement", "text": [ "Serum creatinine level" ], "offsets": [ [ 206, 228 ] ], "normalized": [] }, { "id": "NCT02996916_exc_T15", "type": "Value", "text": [ "= 3.0 mg/dL" ], "offsets": [ [ 229, 240 ] ], "normalized": [] }, { "id": "NCT02996916_exc_T16", "type": "Condition", "text": [ "chronic disease" ], "offsets": [ [ 250, 265 ] ], "normalized": [] }, { "id": "NCT02996916_exc_T17", "type": "Condition", "text": [ "r chr", "\nAller" ], "offsets": [ [ 248, 253 ], [ 265, 271 ] ], "normalized": [] }, { "id": "NCT02996916_exc_T18", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 266, 273 ] ], "normalized": [] }, { "id": "NCT02996916_exc_T19", "type": "Drug", "text": [ "any drugs" ], "offsets": [ [ 277, 286 ] ], "normalized": [] }, { "id": "NCT02996916_exc_T20", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 287, 296 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02996916_exc_R1", "type": "Has_scope", "arg1_id": "NCT02996916_exc_T6", "arg2_id": "NCT02996916_exc_T7", "normalized": [] }, { "id": "NCT02996916_exc_R2", "type": "Has_value", "arg1_id": "NCT02996916_exc_T12", "arg2_id": "NCT02996916_exc_T13", "normalized": [] }, { "id": "NCT02996916_exc_R3", "type": "Has_value", "arg1_id": "NCT02996916_exc_T14", "arg2_id": "NCT02996916_exc_T15", "normalized": [] }, { "id": "NCT02996916_exc_R4", "type": "AND", "arg1_id": "NCT02996916_exc_T18", "arg2_id": "NCT02996916_exc_T19", "normalized": [] } ]

[ { "id": "NCT02996916_inc_text", "type": "inclusion", "text": [ "Written informed consent obtained\nMale and female subjects aged 20 years or older at informed consent\nEssential hypertension who had never received angiotensin II receptor antagonists and calcium channel blockers\n" ], "offsets": [ [ 0, 213 ] ] } ]

[ { "id": "NCT02996916_inc_T2", "type": "Person", "text": [ "Male" ], "offsets": [ [ 34, 38 ] ], "normalized": [] }, { "id": "NCT02996916_inc_T3", "type": "Person", "text": [ "female" ], "offsets": [ [ 43, 49 ] ], "normalized": [] }, { "id": "NCT02996916_inc_T4", "type": "Person", "text": [ "aged" ], "offsets": [ [ 59, 63 ] ], "normalized": [] }, { "id": "NCT02996916_inc_T5", "type": "Value", "text": [ "20 years or older" ], "offsets": [ [ 64, 81 ] ], "normalized": [] }, { "id": "NCT02996916_inc_T6", "type": "Temporal", "text": [ "at informed consent" ], "offsets": [ [ 82, 101 ] ], "normalized": [] }, { "id": "NCT02996916_inc_T7", "type": "Reference_point", "text": [ "informed consent" ], "offsets": [ [ 85, 101 ] ], "normalized": [] }, { "id": "NCT02996916_inc_T8", "type": "Condition", "text": [ "Essential hypertension" ], "offsets": [ [ 102, 124 ] ], "normalized": [] }, { "id": "NCT02996916_inc_T9", "type": "Drug", "text": [ "angiotensin II receptor antagonists" ], "offsets": [ [ 148, 183 ] ], "normalized": [] }, { "id": "NCT02996916_inc_T10", "type": "Drug", "text": [ "calcium channel blockers" ], "offsets": [ [ 188, 212 ] ], "normalized": [] }, { "id": "NCT02996916_inc_T11", "type": "Negation", "text": [ "never" ], "offsets": [ [ 133, 138 ] ], "normalized": [] }, { "id": "NCT02996916_inc_T12", "type": "Scope", "text": [ "angiotensin II receptor antagonists and calcium channel blockers" ], "offsets": [ [ 148, 212 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02996916_inc_R1", "type": "Has_value", "arg1_id": "NCT02996916_inc_T4", "arg2_id": "NCT02996916_inc_T5", "normalized": [] }, { "id": "NCT02996916_inc_R2", "type": "Has_index", "arg1_id": "NCT02996916_inc_T6", "arg2_id": "NCT02996916_inc_T7", "normalized": [] }, { "id": "NCT02996916_inc_R3", "type": "Has_negation", "arg1_id": "NCT02996916_inc_T12", "arg2_id": "NCT02996916_inc_T11", "normalized": [] } ]

[ { "id": "NCT02997215_exc_text", "type": "exclusion", "text": [ "Open surgery;\nPatients allergic to lidocaine or other local anesthetics;\nDrug abuser.\n" ], "offsets": [ [ 0, 86 ] ] } ]

[ { "id": "NCT02997215_exc_T1", "type": "Procedure", "text": [ "Open surgery" ], "offsets": [ [ 0, 12 ] ], "normalized": [] }, { "id": "NCT02997215_exc_T2", "type": "Condition", "text": [ "allergic" ], "offsets": [ [ 23, 31 ] ], "normalized": [] }, { "id": "NCT02997215_exc_T3", "type": "Drug", "text": [ "lidocaine" ], "offsets": [ [ 35, 44 ] ], "normalized": [] }, { "id": "NCT02997215_exc_T4", "type": "Drug", "text": [ "local anesthetics" ], "offsets": [ [ 54, 71 ] ], "normalized": [] }, { "id": "NCT02997215_exc_T5", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 48, 53 ] ], "normalized": [] }, { "id": "NCT02997215_exc_T6", "type": "Scope", "text": [ "lidocaine or other local anesthetics" ], "offsets": [ [ 35, 71 ] ], "normalized": [] }, { "id": "NCT02997215_exc_T7", "type": "Condition", "text": [ "Drug abuser" ], "offsets": [ [ 73, 84 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02997215_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02997215_exc_T4", "arg2_id": "NCT02997215_exc_T5", "normalized": [] }, { "id": "NCT02997215_exc_R2", "type": "Has_scope", "arg1_id": "NCT02997215_exc_T2", "arg2_id": "NCT02997215_exc_T6", "normalized": [] } ]

[ { "id": "NCT02997215_inc_text", "type": "inclusion", "text": [ "American Society of Anesthesiologist (ASA) status I-II adult patients undergoing elective laparoscopic cholecystectomy.\n" ], "offsets": [ [ 0, 120 ] ] } ]

[ { "id": "NCT02997215_inc_T1", "type": "Measurement", "text": [ "American Society of Anesthesiologist (ASA)" ], "offsets": [ [ 0, 42 ] ], "normalized": [] }, { "id": "NCT02997215_inc_T2", "type": "Value", "text": [ "status I-II" ], "offsets": [ [ 43, 54 ] ], "normalized": [] }, { "id": "NCT02997215_inc_T3", "type": "Person", "text": [ "adult" ], "offsets": [ [ 55, 60 ] ], "normalized": [] }, { "id": "NCT02997215_inc_T4", "type": "Qualifier", "text": [ "elective" ], "offsets": [ [ 81, 89 ] ], "normalized": [] }, { "id": "NCT02997215_inc_T5", "type": "Procedure", "text": [ "laparoscopic cholecystectomy" ], "offsets": [ [ 90, 118 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02997215_inc_R1", "type": "Has_value", "arg1_id": "NCT02997215_inc_T1", "arg2_id": "NCT02997215_inc_T2", "normalized": [] }, { "id": "NCT02997215_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02997215_inc_T5", "arg2_id": "NCT02997215_inc_T4", "normalized": [] } ]

[ { "id": "NCT03004209_exc_text", "type": "exclusion", "text": [ "Hemoglobin > 12g/dL\nHematochrit >36%\nThrombocytosis > 750K\nAST or ALT > 120\nHIV (+)\nAllergic reaction upon erythropoietin\nUncontrolled hypertension\nmRS before the autoimmune encephalitis > 3\nBreast feeding or pregnancy\nHistory of ischemic stroke or pulmonary thrombosis\nRefuse to be enrolled\n" ], "offsets": [ [ 0, 292 ] ] } ]

[ { "id": "NCT03004209_exc_T1", "type": "Measurement", "text": [ "Hemoglobin" ], "offsets": [ [ 0, 10 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T2", "type": "Value", "text": [ "> 12g/dL" ], "offsets": [ [ 11, 19 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T3", "type": "Measurement", "text": [ "Hematochrit" ], "offsets": [ [ 20, 31 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T4", "type": "Value", "text": [ ">36%" ], "offsets": [ [ 32, 36 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T5", "type": "Measurement", "text": [ "Thrombocytosis" ], "offsets": [ [ 37, 51 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T6", "type": "Value", "text": [ "> 750K" ], "offsets": [ [ 52, 58 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T7", "type": "Measurement", "text": [ "AST" ], "offsets": [ [ 59, 62 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T8", "type": "Measurement", "text": [ "ALT" ], "offsets": [ [ 66, 69 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T9", "type": "Value", "text": [ "> 120" ], "offsets": [ [ 70, 75 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T10", "type": "Scope", "text": [ "AST or ALT" ], "offsets": [ [ 59, 69 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T11", "type": "Condition", "text": [ "HIV (+)" ], "offsets": [ [ 76, 83 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T12", "type": "Condition", "text": [ "Allergic" ], "offsets": [ [ 84, 92 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T13", "type": "Drug", "text": [ "erythropoietin" ], "offsets": [ [ 107, 121 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T14", "type": "Condition", "text": [ "Uncontrolled hypertension" ], "offsets": [ [ 122, 147 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T15", "type": "Condition", "text": [ "autoimmune encephalitis" ], "offsets": [ [ 163, 186 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T16", "type": "Temporal", "text": [ "before the autoimmune encephalitis" ], "offsets": [ [ 152, 186 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T17", "type": "Reference_point", "text": [ "the autoimmune encephalitis" ], "offsets": [ [ 159, 186 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T18", "type": "Measurement", "text": [ "mRS" ], "offsets": [ [ 148, 151 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T19", "type": "Value", "text": [ "> 3" ], "offsets": [ [ 187, 190 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T20", "type": "Condition", "text": [ "pregnancy" ], "offsets": [ [ 209, 218 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T21", "type": "Observation", "text": [ "Breast feeding" ], "offsets": [ [ 191, 205 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T22", "type": "Condition", "text": [ "ischemic stroke" ], "offsets": [ [ 230, 245 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T23", "type": "Condition", "text": [ "pulmonary thrombosis" ], "offsets": [ [ 249, 269 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T24", "type": "Observation", "text": [ "History" ], "offsets": [ [ 219, 226 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T25", "type": "Scope", "text": [ "ischemic stroke or pulmonary thrombosis" ], "offsets": [ [ 230, 269 ] ], "normalized": [] }, { "id": "NCT03004209_exc_T26", "type": "Observation", "text": [ "Refuse to be enrolled" ], "offsets": [ [ 270, 291 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03004209_exc_R1", "type": "Has_value", "arg1_id": "NCT03004209_exc_T1", "arg2_id": "NCT03004209_exc_T2", "normalized": [] }, { "id": "NCT03004209_exc_R2", "type": "Has_value", "arg1_id": "NCT03004209_exc_T3", "arg2_id": "NCT03004209_exc_T4", "normalized": [] }, { "id": "NCT03004209_exc_R3", "type": "Has_value", "arg1_id": "NCT03004209_exc_T5", "arg2_id": "NCT03004209_exc_T6", "normalized": [] }, { "id": "NCT03004209_exc_R4", "type": "Has_value", "arg1_id": "NCT03004209_exc_T10", "arg2_id": "NCT03004209_exc_T9", "normalized": [] }, { "id": "NCT03004209_exc_R5", "type": "AND", "arg1_id": "NCT03004209_exc_T12", "arg2_id": "NCT03004209_exc_T13", "normalized": [] }, { "id": "NCT03004209_exc_R6", "type": "Has_index", "arg1_id": "NCT03004209_exc_T16", "arg2_id": "NCT03004209_exc_T17", "normalized": [] }, { "id": "NCT03004209_exc_R8", "type": "Has_value", "arg1_id": "NCT03004209_exc_T18", "arg2_id": "NCT03004209_exc_T19", "normalized": [] }, { "id": "NCT03004209_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03004209_exc_T18", "arg2_id": "NCT03004209_exc_T16", "normalized": [] }, { "id": "NCT03004209_exc_R10", "type": "Has_temporal", "arg1_id": "NCT03004209_exc_T25", "arg2_id": "NCT03004209_exc_T24", "normalized": [] } ]

[ { "id": "NCT03004209_inc_text", "type": "inclusion", "text": [ "Clinically diagnosed autoimmune encephalitis\nIneffective 1st line treatment (e.g. steroid IV, IVIg) and 2nd line treatment (e.g. Rituximab or cyclophosphamide)\n" ], "offsets": [ [ 0, 160 ] ] } ]

[ { "id": "NCT03004209_inc_T1", "type": "Qualifier", "text": [ "Clinically diagnosed" ], "offsets": [ [ 0, 20 ] ], "normalized": [] }, { "id": "NCT03004209_inc_T2", "type": "Condition", "text": [ "autoimmune encephalitis" ], "offsets": [ [ 21, 44 ] ], "normalized": [] }, { "id": "NCT03004209_inc_T3", "type": "Qualifier", "text": [ "Ineffective" ], "offsets": [ [ 45, 56 ] ], "normalized": [] }, { "id": "NCT03004209_inc_T4", "type": "Procedure", "text": [ "1st line treatment" ], "offsets": [ [ 57, 75 ] ], "normalized": [] }, { "id": "NCT03004209_inc_T5", "type": "Drug", "text": [ "steroid IV" ], "offsets": [ [ 82, 92 ] ], "normalized": [] }, { "id": "NCT03004209_inc_T6", "type": "Drug", "text": [ "IVIg" ], "offsets": [ [ 94, 98 ] ], "normalized": [] }, { "id": "NCT03004209_inc_T7", "type": "Procedure", "text": [ "2nd line treatment" ], "offsets": [ [ 104, 122 ] ], "normalized": [] }, { "id": "NCT03004209_inc_T8", "type": "Drug", "text": [ "Rituximab" ], "offsets": [ [ 129, 138 ] ], "normalized": [] }, { "id": "NCT03004209_inc_T9", "type": "Drug", "text": [ "cyclophosphamide" ], "offsets": [ [ 142, 158 ] ], "normalized": [] }, { "id": "NCT03004209_inc_T10", "type": "Scope", "text": [ "Rituximab or cyclophosphamide" ], "offsets": [ [ 129, 158 ] ], "normalized": [] }, { "id": "NCT03004209_inc_T11", "type": "Scope", "text": [ "steroid IV, IVIg" ], "offsets": [ [ 82, 98 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03004209_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03004209_inc_T2", "arg2_id": "NCT03004209_inc_T1", "normalized": [] }, { "id": "NCT03004209_inc_R2", "type": "Subsumes", "arg1_id": "NCT03004209_inc_T7", "arg2_id": "NCT03004209_inc_T10", "normalized": [] }, { "id": "NCT03004209_inc_R3", "type": "Subsumes", "arg1_id": "NCT03004209_inc_T4", "arg2_id": "NCT03004209_inc_T11", "normalized": [] }, { "id": "NCT03004209_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT03004209_inc_T4", "arg2_id": "NCT03004209_inc_T3", "normalized": [] }, { "id": "NCT03004209_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT03004209_inc_T7", "arg2_id": "NCT03004209_inc_T3", "normalized": [] } ]

[ { "id": "NCT03004261_exc_text", "type": "exclusion", "text": [ "Patients receiving prednisone = 1mg/kg/d for the treatment of acute GVHD or mild, severe chronic GVHD.\nRecipient < 14years of age\nDonor is sero-positive in HBV/HCV/HIV or RPR.\n" ], "offsets": [ [ 0, 176 ] ] } ]

[ { "id": "NCT03004261_exc_T1", "type": "Drug", "text": [ "prednisone" ], "offsets": [ [ 19, 29 ] ], "normalized": [] }, { "id": "NCT03004261_exc_T2", "type": "Value", "text": [ "= 1mg/kg/d" ], "offsets": [ [ 30, 40 ] ], "normalized": [] }, { "id": "NCT03004261_exc_T3", "type": "Condition", "text": [ "acute GVHD" ], "offsets": [ [ 62, 72 ] ], "normalized": [] }, { "id": "NCT03004261_exc_T4", "type": "Qualifier", "text": [ "mild" ], "offsets": [ [ 76, 80 ] ], "normalized": [] }, { "id": "NCT03004261_exc_T5", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 82, 88 ] ], "normalized": [] }, { "id": "NCT03004261_exc_T6", "type": "Qualifier", "text": [ "chronic" ], "offsets": [ [ 89, 96 ] ], "normalized": [] }, { "id": "NCT03004261_exc_T7", "type": "Condition", "text": [ "GVHD" ], "offsets": [ [ 97, 101 ] ], "normalized": [] }, { "id": "NCT03004261_exc_T8", "type": "Scope", "text": [ "mild, severe" ], "offsets": [ [ 76, 88 ] ], "normalized": [] }, { "id": "NCT03004261_exc_T9", "type": "Scope", "text": [ "acute GVHD or mild, severe chronic GVHD" ], "offsets": [ [ 62, 101 ] ], "normalized": [] }, { "id": "NCT03004261_exc_T10", "type": "Value", "text": [ "< 14years" ], "offsets": [ [ 113, 122 ] ], "normalized": [] }, { "id": "NCT03004261_exc_T11", "type": "Person", "text": [ "age" ], "offsets": [ [ 126, 129 ] ], "normalized": [] }, { "id": "NCT03004261_exc_T12", "type": "Condition", "text": [ "ro-positive in H", "V/H" ], "offsets": [ [ 141, 157 ], [ 158, 161 ] ], "normalized": [] }, { "id": "NCT03004261_exc_T13", "type": "Condition", "text": [ "ro-positive in H", "V/H" ], "offsets": [ [ 141, 157 ], [ 162, 165 ] ], "normalized": [] }, { "id": "NCT03004261_exc_T14", "type": "Condition", "text": [ "ro-positive in H", "V o" ], "offsets": [ [ 141, 157 ], [ 166, 169 ] ], "normalized": [] }, { "id": "NCT03004261_exc_T15", "type": "Condition", "text": [ "ro-positive in H", "R." ], "offsets": [ [ 141, 157 ], [ 173, 175 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03004261_exc_R1", "type": "Has_value", "arg1_id": "NCT03004261_exc_T1", "arg2_id": "NCT03004261_exc_T2", "normalized": [] }, { "id": "NCT03004261_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03004261_exc_T7", "arg2_id": "NCT03004261_exc_T6", "normalized": [] }, { "id": "NCT03004261_exc_R3", "type": "Has_scope", "arg1_id": "NCT03004261_exc_T7", "arg2_id": "NCT03004261_exc_T8", "normalized": [] }, { "id": "NCT03004261_exc_R4", "type": "Has_value", "arg1_id": "NCT03004261_exc_T11", "arg2_id": "NCT03004261_exc_T10", "normalized": [] } ]

[ { "id": "NCT03004261_inc_text", "type": "inclusion", "text": [ "Any allogeneic stem cell transplant recipient = 14 years of age and = 60 years of age\nBilirubin/ SGOT/SGPT < 5 × upper normal limits.\nCreatinine < 2 × upper normal limits.\nEjection fraction = 50%, no severe arrhythmia.\nEstimated life expectancy = 6 months.\nPatients' CMV-DNA = 1000cp/ml in treatment group and being negative in prophylactic group.\n" ], "offsets": [ [ 0, 348 ] ] } ]

[ { "id": "NCT03004261_inc_T1", "type": "Procedure", "text": [ "allogeneic stem cell transplant" ], "offsets": [ [ 4, 35 ] ], "normalized": [] }, { "id": "NCT03004261_inc_T2", "type": "Value", "text": [ "= 14 years" ], "offsets": [ [ 46, 56 ] ], "normalized": [] }, { "id": "NCT03004261_inc_T3", "type": "Person", "text": [ "age" ], "offsets": [ [ 60, 63 ] ], "normalized": [] }, { "id": "NCT03004261_inc_T4", "type": "Value", "text": [ "= 60 years" ], "offsets": [ [ 68, 78 ] ], "normalized": [] }, { "id": "NCT03004261_inc_T5", "type": "Person", "text": [ "age" ], "offsets": [ [ 82, 85 ] ], "normalized": [] }, { "id": "NCT03004261_inc_T6", "type": "Measurement", "text": [ "Bilirubin" ], "offsets": [ [ 86, 95 ] ], "normalized": [] }, { "id": "NCT03004261_inc_T7", "type": "Measurement", "text": [ "SGOT" ], "offsets": [ [ 97, 101 ] ], "normalized": [] }, { "id": "NCT03004261_inc_T8", "type": "Measurement", "text": [ "SGPT" ], "offsets": [ [ 102, 106 ] ], "normalized": [] }, { "id": "NCT03004261_inc_T9", "type": "Value", "text": [ "< 5 × upper normal limits" ], "offsets": [ [ 107, 132 ] ], "normalized": [] }, { "id": "NCT03004261_inc_T10", "type": "Measurement", "text": [ "Creatinine" ], "offsets": [ [ 134, 144 ] ], "normalized": [] }, { "id": "NCT03004261_inc_T11", "type": "Value", "text": [ "< 2 × upper normal limits" ], "offsets": [ [ 145, 170 ] ], "normalized": [] }, { "id": "NCT03004261_inc_T12", "type": "Measurement", "text": [ "Ejection fraction" ], "offsets": [ [ 172, 189 ] ], "normalized": [] }, { "id": "NCT03004261_inc_T13", "type": "Value", "text": [ "= 50%" ], "offsets": [ [ 190, 195 ] ], "normalized": [] }, { "id": "NCT03004261_inc_T14", "type": "Negation", "text": [ "no" ], "offsets": [ [ 197, 199 ] ], "normalized": [] }, { "id": "NCT03004261_inc_T15", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 200, 206 ] ], "normalized": [] }, { "id": "NCT03004261_inc_T16", "type": "Condition", "text": [ "arrhythmia" ], "offsets": [ [ 207, 217 ] ], "normalized": [] }, { "id": "NCT03004261_inc_T17", "type": "Observation", "text": [ "Estimated life expectancy" ], "offsets": [ [ 219, 244 ] ], "normalized": [] }, { "id": "NCT03004261_inc_T18", "type": "Value", "text": [ "= 6 months" ], "offsets": [ [ 245, 255 ] ], "normalized": [] }, { "id": "NCT03004261_inc_T19", "type": "Measurement", "text": [ "CMV-DNA" ], "offsets": [ [ 267, 274 ] ], "normalized": [] }, { "id": "NCT03004261_inc_T20", "type": "Value", "text": [ "= 1000cp/ml" ], "offsets": [ [ 275, 286 ] ], "normalized": [] }, { "id": "NCT03004261_inc_T21", "type": "Person", "text": [ "treatment group" ], "offsets": [ [ 290, 305 ] ], "normalized": [] }, { "id": "NCT03004261_inc_T22", "type": "Person", "text": [ "prophylactic group" ], "offsets": [ [ 328, 346 ] ], "normalized": [] }, { "id": "NCT03004261_inc_T23", "type": "Value", "text": [ "negative" ], "offsets": [ [ 316, 324 ] ], "normalized": [] }, { "id": "NCT03004261_inc_T24", "type": "Scope", "text": [ "= 1000cp/ml in treatment group and being negative in prophylactic group" ], "offsets": [ [ 275, 346 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03004261_inc_R1", "type": "Has_value", "arg1_id": "NCT03004261_inc_T5", "arg2_id": "NCT03004261_inc_T4", "normalized": [] }, { "id": "NCT03004261_inc_R2", "type": "Has_value", "arg1_id": "NCT03004261_inc_T3", "arg2_id": "NCT03004261_inc_T2", "normalized": [] }, { "id": "NCT03004261_inc_R3", "type": "Has_value", "arg1_id": "NCT03004261_inc_T8", "arg2_id": "NCT03004261_inc_T9", "normalized": [] }, { "id": "NCT03004261_inc_R4", "type": "Has_value", "arg1_id": "NCT03004261_inc_T7", "arg2_id": "NCT03004261_inc_T9", "normalized": [] }, { "id": "NCT03004261_inc_R5", "type": "Has_value", "arg1_id": "NCT03004261_inc_T6", "arg2_id": "NCT03004261_inc_T9", "normalized": [] }, { "id": "NCT03004261_inc_R6", "type": "Has_value", "arg1_id": "NCT03004261_inc_T10", "arg2_id": "NCT03004261_inc_T11", "normalized": [] }, { "id": "NCT03004261_inc_R7", "type": "Has_qualifier", "arg1_id": "NCT03004261_inc_T16", "arg2_id": "NCT03004261_inc_T15", "normalized": [] }, { "id": "NCT03004261_inc_R8", "type": "Has_negation", "arg1_id": "NCT03004261_inc_T16", "arg2_id": "NCT03004261_inc_T14", "normalized": [] }, { "id": "NCT03004261_inc_R9", "type": "Has_value", "arg1_id": "NCT03004261_inc_T12", "arg2_id": "NCT03004261_inc_T13", "normalized": [] }, { "id": "NCT03004261_inc_R10", "type": "Has_value", "arg1_id": "NCT03004261_inc_T17", "arg2_id": "NCT03004261_inc_T18", "normalized": [] }, { "id": "NCT03004261_inc_R11", "type": "Has_value", "arg1_id": "NCT03004261_inc_T22", "arg2_id": "NCT03004261_inc_T23", "normalized": [] }, { "id": "NCT03004261_inc_R12", "type": "Has_value", "arg1_id": "NCT03004261_inc_T21", "arg2_id": "NCT03004261_inc_T20", "normalized": [] }, { "id": "NCT03004261_inc_R13", "type": "Has_scope", "arg1_id": "NCT03004261_inc_T19", "arg2_id": "NCT03004261_inc_T24", "normalized": [] } ]

[ { "id": "NCT03008005_exc_text", "type": "exclusion", "text": [ "clinically significant medical or neurologic condition or neurocognitive dysfunction that would affect function and/or task performance and/or interfere with the study protocol\nany current (or within past 2 months) medical condition requiring medication that would interact with dronabinol or interfere with the study protocol\nrisk of harm to self or others that requires immediate intervention\npresence of contraindications, current or past allergic or adverse reaction, or known sensitivity to cannabinoid-like substances (dronabinol/marijuana/cannabis/THC, cannabinoid oil, sesame oil, gelatin, glycerin, and titanium dioxide)\nlack of fluency in English\npositive drug screen or alcohol breathalyzer\nunwilling/unable to sign informed consent document\ncurrently pregnant (positive pregnancy test), planning pregnancy, or lactating (women)\nunder 18 or over 50 years of age\ntraumatic brain injury (as defined by The American Congress of Rehabilitation as a person who has had a traumatically induced physiological disruption of brain function (i.e., the head being struck, the head striking an object, and/or the brain undergoing an acceleration/deceleration movement (i.e., whiplash) without direct external trauma to the head), as manifested by at least one of the following: any loss of consciousness; any loss of memory for events immediately before or after the injury; any alteration in mental status at the time of the incident; or focal neurological deficits that may or may not be transient)\ninability to tolerate small, enclosed spaces without anxiety (e.g. claustrophobia), as determined by self-report and/or a preliminary session in a mock scanner\nleft-handed;\npresence of ferrous-containing metals within the body (e.g., aneurysm clips, shrapnel/retained particles)\nanticipation of a required drug test in the 4 weeks following the study.\ncurrent diagnosis of a mood, anxiety, or other disorder that is more clinically salient than PTSD\ncurrent moderate or severe alcohol/drug use disorder or in the past 8 weeks\ncurrent or past diagnosis of bipolar and other related disorders, schizophrenia spectrum, or other psychotic disorders\nconcomitant treatments with medication known to have drug interactions with dronabinol, such as, central nervous system depressants (barbiturates, benzodiazepines, buspirone, lithium, etc) and anticholinergic agents (atropine, scopolamine, antihistamines, etc).\n" ], "offsets": [ [ 0, 2407 ] ] } ]

[ { "id": "NCT03008005_exc_T1", "type": "Qualifier", "text": [ "clinically significant" ], "offsets": [ [ 0, 22 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T2", "type": "Condition", "text": [ "neurologic condition" ], "offsets": [ [ 34, 54 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T3", "type": "Condition", "text": [ "medical", "condition" ], "offsets": [ [ 23, 30 ], [ 45, 54 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T4", "type": "Condition", "text": [ "neurocognitive dysfunction" ], "offsets": [ [ 58, 84 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T5", "type": "Scope", "text": [ "medical or neurologic condition or neurocognitive dysfunction" ], "offsets": [ [ 23, 84 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T6", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 181, 188 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T7", "type": "Temporal", "text": [ "within past 2 months" ], "offsets": [ [ 193, 213 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T8", "type": "Condition", "text": [ "medical condition" ], "offsets": [ [ 215, 232 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T9", "type": "Drug", "text": [ "medication" ], "offsets": [ [ 243, 253 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T10", "type": "Mood", "text": [ "would interact with" ], "offsets": [ [ 259, 278 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T11", "type": "Drug", "text": [ "dronabinol" ], "offsets": [ [ 279, 289 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T12", "type": "Mood", "text": [ "interfere with the study protocol" ], "offsets": [ [ 293, 326 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T13", "type": "Scope", "text": [ "would interact with dronabinol or interfere with the study protocol" ], "offsets": [ [ 259, 326 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T15", "type": "Condition", "text": [ "contraindications" ], "offsets": [ [ 407, 424 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T16", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 426, 433 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T17", "type": "Temporal", "text": [ "past" ], "offsets": [ [ 437, 441 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T18", "type": "Condition", "text": [ "ergic or", "ction, o" ], "offsets": [ [ 445, 453 ], [ 465, 473 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T19", "type": "Condition", "text": [ "adverse reaction" ], "offsets": [ [ 454, 470 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T20", "type": "Condition", "text": [ "sensitivity" ], "offsets": [ [ 481, 492 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T21", "type": "Drug", "text": [ "cannabinoid-like substances" ], "offsets": [ [ 496, 523 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T22", "type": "Drug", "text": [ "dronabinol" ], "offsets": [ [ 525, 535 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T23", "type": "Drug", "text": [ "marijuana" ], "offsets": [ [ 536, 545 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T24", "type": "Drug", "text": [ "cannabis" ], "offsets": [ [ 546, 554 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T25", "type": "Drug", "text": [ "THC" ], "offsets": [ [ 555, 558 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T26", "type": "Drug", "text": [ "cannabinoid oil" ], "offsets": [ [ 560, 575 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T27", "type": "Drug", "text": [ "sesame oil" ], "offsets": [ [ 577, 587 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T28", "type": "Drug", "text": [ "gelatin" ], "offsets": [ [ 589, 596 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T29", "type": "Drug", "text": [ "glycerin" ], "offsets": [ [ 598, 606 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T30", "type": "Drug", "text": [ "titanium dioxide" ], "offsets": [ [ 612, 628 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T31", "type": "Scope", "text": [ "dronabinol/marijuana/cannabis/THC, cannabinoid oil, sesame oil, gelatin, glycerin, and titanium dioxide" ], "offsets": [ [ 525, 628 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T32", "type": "Scope", "text": [ "allergic or adverse reaction" ], "offsets": [ [ 442, 470 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T33", "type": "Scope", "text": [ "current or past" ], "offsets": [ [ 426, 441 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T35", "type": "Measurement", "text": [ "drug screen" ], "offsets": [ [ 666, 677 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T36", "type": "Value", "text": [ "positive" ], "offsets": [ [ 657, 665 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T37", "type": "Measurement", "text": [ "alcohol breathalyzer" ], "offsets": [ [ 681, 701 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T38", "type": "Scope", "text": [ "drug screen or alcohol breathalyzer" ], "offsets": [ [ 666, 701 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T40", "type": "Temporal", "text": [ "currently" ], "offsets": [ [ 753, 762 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T41", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 763, 771 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T42", "type": "Measurement", "text": [ "pregnancy test" ], "offsets": [ [ 782, 796 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T43", "type": "Value", "text": [ "positive" ], "offsets": [ [ 773, 781 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T44", "type": "Mood", "text": [ "planning" ], "offsets": [ [ 799, 807 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T45", "type": "Condition", "text": [ "pregnancy" ], "offsets": [ [ 808, 817 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T46", "type": "Condition", "text": [ "lactating" ], "offsets": [ [ 822, 831 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T47", "type": "Scope", "text": [ "currently pregnant" ], "offsets": [ [ 753, 771 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T48", "type": "Value", "text": [ "under 18 or over 50 years" ], "offsets": [ [ 840, 865 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T49", "type": "Person", "text": [ "age" ], "offsets": [ [ 869, 872 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T50", "type": "Condition", "text": [ "traumatic brain injury" ], "offsets": [ [ 873, 895 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T52", "type": "Condition", "text": [ "claustrophobia" ], "offsets": [ [ 1567, 1581 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T53", "type": "Condition", "text": [ "tolerate small, enclosed spaces without anxiety" ], "offsets": [ [ 1513, 1560 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T54", "type": "Mood", "text": [ "inability" ], "offsets": [ [ 1500, 1509 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T55", "type": "Negation", "text": [ "inability" ], "offsets": [ [ 1500, 1509 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T56", "type": "Procedure", "text": [ "self-report" ], "offsets": [ [ 1601, 1612 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T57", "type": "Condition", "text": [ "left-handed" ], "offsets": [ [ 1660, 1671 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T58", "type": "Device", "text": [ "ferrous-containing metals" ], "offsets": [ [ 1685, 1710 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T59", "type": "Device", "text": [ "aneurysm clips" ], "offsets": [ [ 1734, 1748 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T60", "type": "Device", "text": [ "shrapnel" ], "offsets": [ [ 1750, 1758 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T61", "type": "Device", "text": [ "retained particles" ], "offsets": [ [ 1759, 1777 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T62", "type": "Scope", "text": [ "aneurysm clips, shrapnel/retained particles" ], "offsets": [ [ 1734, 1777 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T63", "type": "Temporal", "text": [ "in the 4 weeks following the study" ], "offsets": [ [ 1816, 1850 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T64", "type": "Procedure", "text": [ "drug test" ], "offsets": [ [ 1806, 1815 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T65", "type": "Mood", "text": [ "anticipation of" ], "offsets": [ [ 1779, 1794 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T66", "type": "Condition", "text": [ " o", "is more" ], "offsets": [ [ 1889, 1891 ], [ 1913, 1920 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T67", "type": "Condition", "text": [ "her dis", "is more" ], "offsets": [ [ 1895, 1902 ], [ 1913, 1920 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T68", "type": "Condition", "text": [ "disorder" ], "offsets": [ [ 1899, 1907 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T69", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 1893, 1898 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T70", "type": "Condition", "text": [ "PTSD" ], "offsets": [ [ 1945, 1949 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T71", "type": "Qualifier", "text": [ "more clinically salient than PTSD" ], "offsets": [ [ 1916, 1949 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T72", "type": "Scope", "text": [ "mood, anxiety, or other disorder" ], "offsets": [ [ 1875, 1907 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T73", "type": "Qualifier", "text": [ "moderate" ], "offsets": [ [ 1958, 1966 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T74", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 1970, 1976 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T75", "type": "Condition", "text": [ "e disor", " in the pas" ], "offsets": [ [ 1992, 1999 ], [ 2005, 2016 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T76", "type": "Condition", "text": [ "drug use disorder" ], "offsets": [ [ 1985, 2002 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T77", "type": "Scope", "text": [ "alcohol/drug use disorder" ], "offsets": [ [ 1977, 2002 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T78", "type": "Scope", "text": [ "moderate or severe" ], "offsets": [ [ 1958, 1976 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T79", "type": "Temporal", "text": [ "in the past 8 weeks" ], "offsets": [ [ 2006, 2025 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T80", "type": "Condition", "text": [ "bipolar" ], "offsets": [ [ 2055, 2062 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T81", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 2067, 2072 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T82", "type": "Condition", "text": [ "related disorders" ], "offsets": [ [ 2073, 2090 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T83", "type": "Condition", "text": [ "schizophrenia spectrum" ], "offsets": [ [ 2092, 2114 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T84", "type": "Condition", "text": [ "psychotic disorders" ], "offsets": [ [ 2125, 2144 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T85", "type": "Procedure", "text": [ "treatments" ], "offsets": [ [ 2157, 2167 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T86", "type": "Drug", "text": [ "medication" ], "offsets": [ [ 2173, 2183 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T87", "type": "Condition", "text": [ "drug interactions" ], "offsets": [ [ 2198, 2215 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T88", "type": "Drug", "text": [ "dronabinol" ], "offsets": [ [ 2221, 2231 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T89", "type": "Drug", "text": [ "central nervous system depressants" ], "offsets": [ [ 2242, 2276 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T90", "type": "Drug", "text": [ "barbiturates" ], "offsets": [ [ 2278, 2290 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T91", "type": "Drug", "text": [ "benzodiazepines" ], "offsets": [ [ 2292, 2307 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T92", "type": "Drug", "text": [ "buspirone" ], "offsets": [ [ 2309, 2318 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T93", "type": "Drug", "text": [ "lithium" ], "offsets": [ [ 2320, 2327 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T94", "type": "Scope", "text": [ "barbiturates, benzodiazepines, buspirone, lithium" ], "offsets": [ [ 2278, 2327 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T95", "type": "Drug", "text": [ "anticholinergic agents" ], "offsets": [ [ 2338, 2360 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T96", "type": "Drug", "text": [ "atropine" ], "offsets": [ [ 2362, 2370 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T97", "type": "Drug", "text": [ "scopolamine" ], "offsets": [ [ 2372, 2383 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T98", "type": "Drug", "text": [ "antihistamines" ], "offsets": [ [ 2385, 2399 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T99", "type": "Scope", "text": [ "atropine, scopolamine, antihistamines" ], "offsets": [ [ 2362, 2399 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T100", "type": "Scope", "text": [ "central nervous system depressants (barbiturates, benzodiazepines, buspirone, lithium, etc) and anticholinergic agents (atropine, scopolamine, antihistamines, etc)" ], "offsets": [ [ 2242, 2405 ] ], "normalized": [] }, { "id": "NCT03008005_exc_T101", "type": "Scope", "text": [ "contraindications, current or past allergic or adverse reaction, or known sensitivity" ], "offsets": [ [ 407, 492 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03008005_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03008005_exc_T5", "arg2_id": "NCT03008005_exc_T1", "normalized": [] }, { "id": "NCT03008005_exc_R2", "type": "Subsumes", "arg1_id": "NCT03008005_exc_T6", "arg2_id": "NCT03008005_exc_T7", "normalized": [] }, { "id": "NCT03008005_exc_R3", "type": "Has_mood", "arg1_id": "NCT03008005_exc_T11", "arg2_id": "NCT03008005_exc_T10", "normalized": [] }, { "id": "NCT03008005_exc_R4", "type": "Has_scope", "arg1_id": "NCT03008005_exc_T9", "arg2_id": "NCT03008005_exc_T13", "normalized": [] }, { "id": "NCT03008005_exc_R5", "type": "AND", "arg1_id": "NCT03008005_exc_T8", "arg2_id": "NCT03008005_exc_T9", "normalized": [] }, { "id": "NCT03008005_exc_R6", "type": "Has_temporal", "arg1_id": "NCT03008005_exc_T8", "arg2_id": "NCT03008005_exc_T6", "normalized": [] }, { "id": "NCT03008005_exc_R7", "type": "Subsumes", "arg1_id": "NCT03008005_exc_T21", "arg2_id": "NCT03008005_exc_T31", "normalized": [] }, { "id": "NCT03008005_exc_R9", "type": "Has_scope", "arg1_id": "NCT03008005_exc_T32", "arg2_id": "NCT03008005_exc_T33", "normalized": [] }, { "id": "NCT03008005_exc_R10", "type": "Has_value", "arg1_id": "NCT03008005_exc_T38", "arg2_id": "NCT03008005_exc_T36", "normalized": [] }, { "id": "NCT03008005_exc_R11", "type": "Has_temporal", "arg1_id": "NCT03008005_exc_T41", "arg2_id": "NCT03008005_exc_T40", "normalized": [] }, { "id": "NCT03008005_exc_R12", "type": "Has_value", "arg1_id": "NCT03008005_exc_T42", "arg2_id": "NCT03008005_exc_T43", "normalized": [] }, { "id": "NCT03008005_exc_R13", "type": "Has_mood", "arg1_id": "NCT03008005_exc_T45", "arg2_id": "NCT03008005_exc_T44", "normalized": [] }, { "id": "NCT03008005_exc_R14", "type": "Subsumes", "arg1_id": "NCT03008005_exc_T47", "arg2_id": "NCT03008005_exc_T42", "normalized": [] }, { "id": "NCT03008005_exc_R15", "type": "Has_value", "arg1_id": "NCT03008005_exc_T49", "arg2_id": "NCT03008005_exc_T48", "normalized": [] }, { "id": "NCT03008005_exc_R16", "type": "Has_negation", "arg1_id": "NCT03008005_exc_T53", "arg2_id": "NCT03008005_exc_T55", "normalized": [] }, { "id": "NCT03008005_exc_R18", "type": "Subsumes", "arg1_id": "NCT03008005_exc_T53", "arg2_id": "NCT03008005_exc_T52", "normalized": [] }, { "id": "NCT03008005_exc_R19", "type": "AND", "arg1_id": "NCT03008005_exc_T53", "arg2_id": "NCT03008005_exc_T56", "normalized": [] }, { "id": "NCT03008005_exc_R20", "type": "Subsumes", "arg1_id": "NCT03008005_exc_T58", "arg2_id": "NCT03008005_exc_T62", "normalized": [] }, { "id": "NCT03008005_exc_R21", "type": "Has_temporal", "arg1_id": "NCT03008005_exc_T64", "arg2_id": "NCT03008005_exc_T63", "normalized": [] }, { "id": "NCT03008005_exc_R22", "type": "Has_mood", "arg1_id": "NCT03008005_exc_T64", "arg2_id": "NCT03008005_exc_T65", "normalized": [] }, { "id": "NCT03008005_exc_R23", "type": "Has_qualifier", "arg1_id": "NCT03008005_exc_T68", "arg2_id": "NCT03008005_exc_T69", "normalized": [] }, { "id": "NCT03008005_exc_R25", "type": "Has_qualifier", "arg1_id": "NCT03008005_exc_T72", "arg2_id": "NCT03008005_exc_T71", "normalized": [] }, { "id": "NCT03008005_exc_R26", "type": "Has_scope", "arg1_id": "NCT03008005_exc_T77", "arg2_id": "NCT03008005_exc_T78", "normalized": [] }, { "id": "NCT03008005_exc_R27", "type": "Has_temporal", "arg1_id": "NCT03008005_exc_T77", "arg2_id": "NCT03008005_exc_T79", "normalized": [] }, { "id": "NCT03008005_exc_R28", "type": "Has_qualifier", "arg1_id": "NCT03008005_exc_T82", "arg2_id": "NCT03008005_exc_T81", "normalized": [] }, { "id": "NCT03008005_exc_R29", "type": "Subsumes", "arg1_id": "NCT03008005_exc_T89", "arg2_id": "NCT03008005_exc_T94", "normalized": [] }, { "id": "NCT03008005_exc_R30", "type": "Subsumes", "arg1_id": "NCT03008005_exc_T95", "arg2_id": "NCT03008005_exc_T99", "normalized": [] }, { "id": "NCT03008005_exc_R31", "type": "AND", "arg1_id": "NCT03008005_exc_T87", "arg2_id": "NCT03008005_exc_T88", "normalized": [] }, { "id": "NCT03008005_exc_R33", "type": "AND", "arg1_id": "NCT03008005_exc_T86", "arg2_id": "NCT03008005_exc_T87", "normalized": [] }, { "id": "NCT03008005_exc_R32", "type": "AND", "arg1_id": "NCT03008005_exc_T85", "arg2_id": "NCT03008005_exc_T86", "normalized": [] }, { "id": "NCT03008005_exc_R34", "type": "Subsumes", "arg1_id": "NCT03008005_exc_T86", "arg2_id": "NCT03008005_exc_T100", "normalized": [] }, { "id": "NCT03008005_exc_R8", "type": "AND", "arg1_id": "NCT03008005_exc_T101", "arg2_id": "NCT03008005_exc_T21", "normalized": [] } ]

[ { "id": "NCT03008005_inc_text", "type": "inclusion", "text": [ "Able to give informed consent\nRight-handed\nAge between 18-50 years old,\nPhysically and neurologically healthy [confirmed by a comprehensive medical history]\nCurrent PTSD diagnosis\n" ], "offsets": [ [ 0, 180 ] ] } ]

[ { "id": "NCT03008005_inc_T2", "type": "Condition", "text": [ "Right-handed" ], "offsets": [ [ 30, 42 ] ], "normalized": [] }, { "id": "NCT03008005_inc_T3", "type": "Person", "text": [ "Age" ], "offsets": [ [ 43, 46 ] ], "normalized": [] }, { "id": "NCT03008005_inc_T4", "type": "Value", "text": [ "between 18-50 years old" ], "offsets": [ [ 47, 70 ] ], "normalized": [] }, { "id": "NCT03008005_inc_T5", "type": "Condition", "text": [ "neurologically healthy" ], "offsets": [ [ 87, 109 ] ], "normalized": [] }, { "id": "NCT03008005_inc_T6", "type": "Condition", "text": [ "lthy [c", "sically an" ], "offsets": [ [ 105, 112 ], [ 75, 85 ] ], "normalized": [] }, { "id": "NCT03008005_inc_T7", "type": "Procedure", "text": [ "comprehensive medical history" ], "offsets": [ [ 126, 155 ] ], "normalized": [] }, { "id": "NCT03008005_inc_T8", "type": "Condition", "text": [ "PTSD" ], "offsets": [ [ 165, 169 ] ], "normalized": [] }, { "id": "NCT03008005_inc_T9", "type": "Temporal", "text": [ "Current" ], "offsets": [ [ 157, 164 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03008005_inc_R1", "type": "Has_value", "arg1_id": "NCT03008005_inc_T3", "arg2_id": "NCT03008005_inc_T4", "normalized": [] }, { "id": "NCT03008005_inc_R2", "type": "AND", "arg1_id": "NCT03008005_inc_T6", "arg2_id": "NCT03008005_inc_T7", "normalized": [] }, { "id": "NCT03008005_inc_R3", "type": "AND", "arg1_id": "NCT03008005_inc_T5", "arg2_id": "NCT03008005_inc_T7", "normalized": [] }, { "id": "NCT03008005_inc_R4", "type": "Has_temporal", "arg1_id": "NCT03008005_inc_T8", "arg2_id": "NCT03008005_inc_T9", "normalized": [] } ]

[ { "id": "NCT03011177_exc_text", "type": "exclusion", "text": [ "NA\n\n" ], "offsets": [ [ 0, 4 ] ] } ]

[]

[]

[]

[]

[ { "id": "NCT03011177_inc_text", "type": "inclusion", "text": [ "Patients who are 19 years or older on screening\nPatients with type 2 diabetes mellitus\nPatients with 7.0% = HbA1c = 11.0% at the screening visit\nPatients with Fasting Plasma Glucose <15mmol/L(270mg/dL) on screening\n" ], "offsets": [ [ 0, 215 ] ] } ]

[ { "id": "NCT03011177_inc_T1", "type": "Person", "text": [ "years" ], "offsets": [ [ 20, 25 ] ], "normalized": [] }, { "id": "NCT03011177_inc_T2", "type": "Value", "text": [ "19", "or older" ], "offsets": [ [ 17, 19 ], [ 26, 34 ] ], "normalized": [] }, { "id": "NCT03011177_inc_T3", "type": "Temporal", "text": [ "on screening" ], "offsets": [ [ 35, 47 ] ], "normalized": [] }, { "id": "NCT03011177_inc_T4", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 38, 47 ] ], "normalized": [] }, { "id": "NCT03011177_inc_T5", "type": "Condition", "text": [ "type 2 diabetes mellitus" ], "offsets": [ [ 62, 86 ] ], "normalized": [] }, { "id": "NCT03011177_inc_T6", "type": "Measurement", "text": [ "HbA1c" ], "offsets": [ [ 108, 113 ] ], "normalized": [] }, { "id": "NCT03011177_inc_T7", "type": "Value", "text": [ "0% =", ".0% a" ], "offsets": [ [ 103, 107 ], [ 118, 123 ] ], "normalized": [] }, { "id": "NCT03011177_inc_T8", "type": "Temporal", "text": [ "at the screening visit" ], "offsets": [ [ 122, 144 ] ], "normalized": [] }, { "id": "NCT03011177_inc_T9", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 129, 138 ] ], "normalized": [] }, { "id": "NCT03011177_inc_T10", "type": "Measurement", "text": [ "Fasting Plasma Glucose" ], "offsets": [ [ 159, 181 ] ], "normalized": [] }, { "id": "NCT03011177_inc_T11", "type": "Value", "text": [ "<15mmol/L" ], "offsets": [ [ 182, 191 ] ], "normalized": [] }, { "id": "NCT03011177_inc_T12", "type": "Value", "text": [ "270mg/dL" ], "offsets": [ [ 192, 200 ] ], "normalized": [] }, { "id": "NCT03011177_inc_T13", "type": "Temporal", "text": [ "on screening" ], "offsets": [ [ 202, 214 ] ], "normalized": [] }, { "id": "NCT03011177_inc_T14", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 205, 214 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03011177_inc_R1", "type": "Has_value", "arg1_id": "NCT03011177_inc_T1", "arg2_id": "NCT03011177_inc_T2", "normalized": [] }, { "id": "NCT03011177_inc_R2", "type": "Has_index", "arg1_id": "NCT03011177_inc_T3", "arg2_id": "NCT03011177_inc_T4", "normalized": [] }, { "id": "NCT03011177_inc_R3", "type": "Has_temporal", "arg1_id": "NCT03011177_inc_T1", "arg2_id": "NCT03011177_inc_T3", "normalized": [] }, { "id": "NCT03011177_inc_R4", "type": "Has_index", "arg1_id": "NCT03011177_inc_T8", "arg2_id": "NCT03011177_inc_T9", "normalized": [] }, { "id": "NCT03011177_inc_R5", "type": "Has_value", "arg1_id": "NCT03011177_inc_T6", "arg2_id": "NCT03011177_inc_T7", "normalized": [] }, { "id": "NCT03011177_inc_R6", "type": "Has_temporal", "arg1_id": "NCT03011177_inc_T6", "arg2_id": "NCT03011177_inc_T8", "normalized": [] }, { "id": "NCT03011177_inc_R7", "type": "Subsumes", "arg1_id": "NCT03011177_inc_T11", "arg2_id": "NCT03011177_inc_T12", "normalized": [] }, { "id": "NCT03011177_inc_R8", "type": "Has_index", "arg1_id": "NCT03011177_inc_T13", "arg2_id": "NCT03011177_inc_T14", "normalized": [] }, { "id": "NCT03011177_inc_R9", "type": "Has_value", "arg1_id": "NCT03011177_inc_T10", "arg2_id": "NCT03011177_inc_T11", "normalized": [] } ]

[ { "id": "NCT03011476_exc_text", "type": "exclusion", "text": [ "Significant motor complication affecting daily activities\nDrugs related to acetylcholine metabolism\n" ], "offsets": [ [ 0, 100 ] ] } ]

[ { "id": "NCT03011476_exc_T1", "type": "Condition", "text": [ "motor complication" ], "offsets": [ [ 12, 30 ] ], "normalized": [] }, { "id": "NCT03011476_exc_T2", "type": "Qualifier", "text": [ "Significant" ], "offsets": [ [ 0, 11 ] ], "normalized": [] }, { "id": "NCT03011476_exc_T3", "type": "Drug", "text": [ "Drugs" ], "offsets": [ [ 58, 63 ] ], "normalized": [] }, { "id": "NCT03011476_exc_T4", "type": "Qualifier", "text": [ "related to acetylcholine metabolis" ], "offsets": [ [ 64, 98 ] ], "normalized": [] }, { "id": "NCT03011476_exc_T5", "type": "Drug", "text": [ "acetylcholine" ], "offsets": [ [ 75, 88 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03011476_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03011476_exc_T1", "arg2_id": "NCT03011476_exc_T2", "normalized": [] }, { "id": "NCT03011476_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03011476_exc_T3", "arg2_id": "NCT03011476_exc_T4", "normalized": [] } ]

[ { "id": "NCT03011476_inc_text", "type": "inclusion", "text": [ "Parkinson disease diagnosed by United Kingdom Parkinson's disease Society Brain Bank Criteria\nPostural instability and gait disturbance phenotype\nHoehn and Yahr stage = 3\nMini-Mental status examination = 24\n" ], "offsets": [ [ 0, 207 ] ] } ]

[ { "id": "NCT03011476_inc_T1", "type": "Condition", "text": [ "Parkinson disease" ], "offsets": [ [ 0, 17 ] ], "normalized": [] }, { "id": "NCT03011476_inc_T2", "type": "Measurement", "text": [ "United Kingdom Parkinson's disease Society Brain Bank Criteria" ], "offsets": [ [ 31, 93 ] ], "normalized": [] }, { "id": "NCT03011476_inc_T3", "type": "Condition", "text": [ "Postural instability" ], "offsets": [ [ 94, 114 ] ], "normalized": [] }, { "id": "NCT03011476_inc_T4", "type": "Condition", "text": [ "gait disturbance" ], "offsets": [ [ 119, 135 ] ], "normalized": [] }, { "id": "NCT03011476_inc_T5", "type": "Measurement", "text": [ "Hoehn and Yahr" ], "offsets": [ [ 146, 160 ] ], "normalized": [] }, { "id": "NCT03011476_inc_T6", "type": "Value", "text": [ "stage = 3" ], "offsets": [ [ 161, 170 ] ], "normalized": [] }, { "id": "NCT03011476_inc_T7", "type": "Measurement", "text": [ "Mini-Mental status examination" ], "offsets": [ [ 171, 201 ] ], "normalized": [] }, { "id": "NCT03011476_inc_T8", "type": "Value", "text": [ "= 2" ], "offsets": [ [ 202, 205 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03011476_inc_R1", "type": "AND", "arg1_id": "NCT03011476_inc_T1", "arg2_id": "NCT03011476_inc_T2", "normalized": [] }, { "id": "NCT03011476_inc_R2", "type": "Has_value", "arg1_id": "NCT03011476_inc_T5", "arg2_id": "NCT03011476_inc_T6", "normalized": [] }, { "id": "NCT03011476_inc_R3", "type": "Has_value", "arg1_id": "NCT03011476_inc_T7", "arg2_id": "NCT03011476_inc_T8", "normalized": [] } ]

[ { "id": "NCT03012984_exc_text", "type": "exclusion", "text": [ "Preoperative history of schizophrenia, epilepsy, parkinsonism or myasthenia gravis;\nPreoperative radio- or chemotherapy;\nInability to communicate in the preoperative period because of coma, profound dementia or language barrier;\nPreoperative obstructive sleep apnea (previously diagnosed as obstructive sleep apnea, or a STOP-Bang score >= 3);\nBrain trauma or neurosurgery;\nPreoperative left ventricular ejection fraction < 30%, sick sinus syndrome, severe sinus bradycardia (< 50 beats per minute), or second-degree or above atrioventricular block without pacemaker;\nSevere hepatic dysfunction (Child-Pugh class C) or severe renal dysfunction (requirement of renal replacement therapy before surgery);\nASA classification >= IV.\n" ], "offsets": [ [ 0, 729 ] ] } ]

[ { "id": "NCT03012984_exc_T1", "type": "Condition", "text": [ "schizophrenia" ], "offsets": [ [ 24, 37 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T2", "type": "Condition", "text": [ "epilepsy" ], "offsets": [ [ 39, 47 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T3", "type": "Condition", "text": [ "parkinsonism" ], "offsets": [ [ 49, 61 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T4", "type": "Condition", "text": [ "myasthenia gravis" ], "offsets": [ [ 65, 82 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T5", "type": "Observation", "text": [ "history" ], "offsets": [ [ 13, 20 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T6", "type": "Temporal", "text": [ "Preoperative" ], "offsets": [ [ 0, 12 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T7", "type": "Scope", "text": [ "schizophrenia, epilepsy, parkinsonism or myasthenia gravis" ], "offsets": [ [ 24, 82 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T8", "type": "Procedure", "text": [ "chemotherapy" ], "offsets": [ [ 107, 119 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T9", "type": "Procedure", "text": [ "herapy;", "adio-" ], "offsets": [ [ 113, 120 ], [ 98, 103 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T10", "type": "Temporal", "text": [ "Preoperative" ], "offsets": [ [ 84, 96 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T11", "type": "Scope", "text": [ "radio- or chemotherapy" ], "offsets": [ [ 97, 119 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T12", "type": "Condition", "text": [ "coma" ], "offsets": [ [ 184, 188 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T13", "type": "Condition", "text": [ "dementia" ], "offsets": [ [ 199, 207 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T14", "type": "Qualifier", "text": [ "profound" ], "offsets": [ [ 190, 198 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T15", "type": "Observation", "text": [ "language barrier" ], "offsets": [ [ 211, 227 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T16", "type": "Temporal", "text": [ "preoperative period" ], "offsets": [ [ 153, 172 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T17", "type": "Condition", "text": [ "Inability to communicate" ], "offsets": [ [ 121, 145 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T18", "type": "Scope", "text": [ "coma, profound dementia or language barrier" ], "offsets": [ [ 184, 227 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T19", "type": "Condition", "text": [ "obstructive sleep apnea" ], "offsets": [ [ 242, 265 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T20", "type": "Temporal", "text": [ "Preoperative" ], "offsets": [ [ 229, 241 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T21", "type": "Condition", "text": [ "obstructive sleep apnea" ], "offsets": [ [ 291, 314 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T22", "type": "Measurement", "text": [ "STOP-Bang score" ], "offsets": [ [ 321, 336 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T23", "type": "Value", "text": [ ">= 3" ], "offsets": [ [ 337, 341 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T24", "type": "Scope", "text": [ "obstructive sleep apnea, or a STOP-Bang score >= 3" ], "offsets": [ [ 291, 341 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T25", "type": "Scope", "text": [ "Preoperative obstructive sleep apnea" ], "offsets": [ [ 229, 265 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T26", "type": "Condition", "text": [ "Brain trauma" ], "offsets": [ [ 344, 356 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T27", "type": "Procedure", "text": [ "neurosurgery" ], "offsets": [ [ 360, 372 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T28", "type": "Measurement", "text": [ "left ventricular ejection fraction" ], "offsets": [ [ 387, 421 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T29", "type": "Value", "text": [ "< 30%" ], "offsets": [ [ 422, 427 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T30", "type": "Temporal", "text": [ "Preoperative" ], "offsets": [ [ 374, 386 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T31", "type": "Condition", "text": [ "sick sinus syndrome" ], "offsets": [ [ 429, 448 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T32", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 450, 456 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T33", "type": "Condition", "text": [ "sinus bradycardia" ], "offsets": [ [ 457, 474 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T34", "type": "Value", "text": [ "< 50 beats per minute" ], "offsets": [ [ 476, 497 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T35", "type": "Condition", "text": [ "atrioventricular block" ], "offsets": [ [ 526, 548 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T36", "type": "Negation", "text": [ "without" ], "offsets": [ [ 549, 556 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T37", "type": "Device", "text": [ "pacemaker" ], "offsets": [ [ 557, 566 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T38", "type": "Qualifier", "text": [ "second-degree or above" ], "offsets": [ [ 503, 525 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T39", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 568, 574 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T40", "type": "Condition", "text": [ "hepatic dysfunction" ], "offsets": [ [ 575, 594 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T41", "type": "Measurement", "text": [ "Child-Pugh" ], "offsets": [ [ 596, 606 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T42", "type": "Value", "text": [ "class C" ], "offsets": [ [ 607, 614 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T43", "type": "Scope", "text": [ "Severe hepatic dysfunction" ], "offsets": [ [ 568, 594 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T44", "type": "Scope", "text": [ "Child-Pugh class C" ], "offsets": [ [ 596, 614 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T45", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 619, 625 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T46", "type": "Condition", "text": [ "renal dysfunction" ], "offsets": [ [ 626, 643 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T47", "type": "Procedure", "text": [ "renal replacement therapy" ], "offsets": [ [ 660, 685 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T48", "type": "Temporal", "text": [ "before surgery" ], "offsets": [ [ 686, 700 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T49", "type": "Reference_point", "text": [ "surgery" ], "offsets": [ [ 693, 700 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T50", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 693, 700 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T51", "type": "Scope", "text": [ "severe renal dysfunction" ], "offsets": [ [ 619, 643 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T52", "type": "Scope", "text": [ "renal replacement therapy before surgery" ], "offsets": [ [ 660, 700 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T53", "type": "Measurement", "text": [ "ASA classification" ], "offsets": [ [ 703, 721 ] ], "normalized": [] }, { "id": "NCT03012984_exc_T54", "type": "Value", "text": [ ">= IV" ], "offsets": [ [ 722, 727 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03012984_exc_R1", "type": "Has_temporal", "arg1_id": "NCT03012984_exc_T5", "arg2_id": "NCT03012984_exc_T6", "normalized": [] }, { "id": "NCT03012984_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03012984_exc_T7", "arg2_id": "NCT03012984_exc_T5", "normalized": [] }, { "id": "NCT03012984_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03012984_exc_T11", "arg2_id": "NCT03012984_exc_T10", "normalized": [] }, { "id": "NCT03012984_exc_R4", "type": "Has_temporal", "arg1_id": "NCT03012984_exc_T17", "arg2_id": "NCT03012984_exc_T16", "normalized": [] }, { "id": "NCT03012984_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT03012984_exc_T13", "arg2_id": "NCT03012984_exc_T14", "normalized": [] }, { "id": "NCT03012984_exc_R6", "type": "Has_scope", "arg1_id": "NCT03012984_exc_T17", "arg2_id": "NCT03012984_exc_T18", "normalized": [] }, { "id": "NCT03012984_exc_R7", "type": "Has_temporal", "arg1_id": "NCT03012984_exc_T19", "arg2_id": "NCT03012984_exc_T20", "normalized": [] }, { "id": "NCT03012984_exc_R8", "type": "Has_value", "arg1_id": "NCT03012984_exc_T22", "arg2_id": "NCT03012984_exc_T23", "normalized": [] }, { "id": "NCT03012984_exc_R9", "type": "Subsumes", "arg1_id": "NCT03012984_exc_T25", "arg2_id": "NCT03012984_exc_T24", "normalized": [] }, { "id": "NCT03012984_exc_R10", "type": "Has_value", "arg1_id": "NCT03012984_exc_T28", "arg2_id": "NCT03012984_exc_T29", "normalized": [] }, { "id": "NCT03012984_exc_R11", "type": "Has_temporal", "arg1_id": "NCT03012984_exc_T28", "arg2_id": "NCT03012984_exc_T30", "normalized": [] }, { "id": "NCT03012984_exc_R12", "type": "Has_value", "arg1_id": "NCT03012984_exc_T33", "arg2_id": "NCT03012984_exc_T34", "normalized": [] }, { "id": "NCT03012984_exc_R13", "type": "Has_qualifier", "arg1_id": "NCT03012984_exc_T33", "arg2_id": "NCT03012984_exc_T32", "normalized": [] }, { "id": "NCT03012984_exc_R14", "type": "Has_negation", "arg1_id": "NCT03012984_exc_T37", "arg2_id": "NCT03012984_exc_T36", "normalized": [] }, { "id": "NCT03012984_exc_R15", "type": "AND", "arg1_id": "NCT03012984_exc_T35", "arg2_id": "NCT03012984_exc_T37", "normalized": [] }, { "id": "NCT03012984_exc_R16", "type": "Has_qualifier", "arg1_id": "NCT03012984_exc_T35", "arg2_id": "NCT03012984_exc_T38", "normalized": [] }, { "id": "NCT03012984_exc_R17", "type": "Has_value", "arg1_id": "NCT03012984_exc_T41", "arg2_id": "NCT03012984_exc_T42", "normalized": [] }, { "id": "NCT03012984_exc_R18", "type": "Has_qualifier", "arg1_id": "NCT03012984_exc_T40", "arg2_id": "NCT03012984_exc_T39", "normalized": [] }, { "id": "NCT03012984_exc_R19", "type": "Subsumes", "arg1_id": "NCT03012984_exc_T43", "arg2_id": "NCT03012984_exc_T44", "normalized": [] }, { "id": "NCT03012984_exc_R20", "type": "Has_qualifier", "arg1_id": "NCT03012984_exc_T46", "arg2_id": "NCT03012984_exc_T45", "normalized": [] }, { "id": "NCT03012984_exc_R21", "type": "Has_index", "arg1_id": "NCT03012984_exc_T48", "arg2_id": "NCT03012984_exc_T49", "normalized": [] }, { "id": "NCT03012984_exc_R23", "type": "Has_temporal", "arg1_id": "NCT03012984_exc_T47", "arg2_id": "NCT03012984_exc_T48", "normalized": [] }, { "id": "NCT03012984_exc_R24", "type": "Subsumes", "arg1_id": "NCT03012984_exc_T51", "arg2_id": "NCT03012984_exc_T52", "normalized": [] }, { "id": "NCT03012984_exc_R25", "type": "Has_value", "arg1_id": "NCT03012984_exc_T53", "arg2_id": "NCT03012984_exc_T54", "normalized": [] } ]

[ { "id": "NCT03012984_inc_text", "type": "inclusion", "text": [ "Age >= 65 years, < 90 years;\nScheduled to undergo surgery for primary solid organ cancer under general anesthesia, with an expected duration of surgery >=2 hours;\nPlanned to use patient-controlled intravenous analgesia after surgery;\nProvide written informed consent.\n" ], "offsets": [ [ 0, 268 ] ] } ]

[ { "id": "NCT03012984_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03012984_inc_T2", "type": "Value", "text": [ ">= 65 years, < 90 years" ], "offsets": [ [ 4, 27 ] ], "normalized": [] }, { "id": "NCT03012984_inc_T3", "type": "Mood", "text": [ "Scheduled" ], "offsets": [ [ 29, 38 ] ], "normalized": [] }, { "id": "NCT03012984_inc_T4", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 50, 57 ] ], "normalized": [] }, { "id": "NCT03012984_inc_T5", "type": "Qualifier", "text": [ "primary" ], "offsets": [ [ 62, 69 ] ], "normalized": [] }, { "id": "NCT03012984_inc_T6", "type": "Condition", "text": [ "solid organ cancer" ], "offsets": [ [ 70, 88 ] ], "normalized": [] }, { "id": "NCT03012984_inc_T7", "type": "Procedure", "text": [ "general anesthesia" ], "offsets": [ [ 95, 113 ] ], "normalized": [] }, { "id": "NCT03012984_inc_T9", "type": "Qualifier", "text": [ "patient-controlled" ], "offsets": [ [ 178, 196 ] ], "normalized": [] }, { "id": "NCT03012984_inc_T10", "type": "Procedure", "text": [ "intravenous analgesia" ], "offsets": [ [ 197, 218 ] ], "normalized": [] }, { "id": "NCT03012984_inc_T11", "type": "Temporal", "text": [ "after surgery" ], "offsets": [ [ 219, 232 ] ], "normalized": [] }, { "id": "NCT03012984_inc_T12", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 225, 232 ] ], "normalized": [] }, { "id": "NCT03012984_inc_T13", "type": "Reference_point", "text": [ "surgery" ], "offsets": [ [ 225, 232 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03012984_inc_R1", "type": "Has_value", "arg1_id": "NCT03012984_inc_T1", "arg2_id": "NCT03012984_inc_T2", "normalized": [] }, { "id": "NCT03012984_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03012984_inc_T6", "arg2_id": "NCT03012984_inc_T5", "normalized": [] }, { "id": "NCT03012984_inc_R3", "type": "AND", "arg1_id": "NCT03012984_inc_T4", "arg2_id": "NCT03012984_inc_T6", "normalized": [] }, { "id": "NCT03012984_inc_R4", "type": "AND", "arg1_id": "NCT03012984_inc_T4", "arg2_id": "NCT03012984_inc_T7", "normalized": [] }, { "id": "NCT03012984_inc_R5", "type": "Has_mood", "arg1_id": "NCT03012984_inc_T4", "arg2_id": "NCT03012984_inc_T3", "normalized": [] }, { "id": "NCT03012984_inc_R6", "type": "Has_qualifier", "arg1_id": "NCT03012984_inc_T10", "arg2_id": "NCT03012984_inc_T9", "normalized": [] }, { "id": "NCT03012984_inc_R7", "type": "Has_temporal", "arg1_id": "NCT03012984_inc_T10", "arg2_id": "NCT03012984_inc_T11", "normalized": [] }, { "id": "NCT03012984_inc_R8", "type": "Has_index", "arg1_id": "NCT03012984_inc_T11", "arg2_id": "NCT03012984_inc_T13", "normalized": [] } ]

[ { "id": "NCT03013790_exc_text", "type": "exclusion", "text": [ "Patients with head trauma or Neurosurgical intervention\nPatients <65 years of age\nPatients with an expected life expectancy <48 hours\nBlind patients\nPatients with a seizure history\nPatients with uncontrolled hypertension\nPatients with a supratheraputic (>3.0) INR\nPatients on strong CYP1A2 inhibitors: ciprofloxacin, fluvoxamine, methoxsalen, ofloxacin, primaquine\nPatients who do not speak English or Spanish\n" ], "offsets": [ [ 0, 410 ] ] } ]

[ { "id": "NCT03013790_exc_T1", "type": "Condition", "text": [ "head trauma" ], "offsets": [ [ 14, 25 ] ], "normalized": [] }, { "id": "NCT03013790_exc_T2", "type": "Procedure", "text": [ "Neurosurgical intervention" ], "offsets": [ [ 29, 55 ] ], "normalized": [] }, { "id": "NCT03013790_exc_T3", "type": "Value", "text": [ "<65 years" ], "offsets": [ [ 65, 74 ] ], "normalized": [] }, { "id": "NCT03013790_exc_T4", "type": "Person", "text": [ "age" ], "offsets": [ [ 78, 81 ] ], "normalized": [] }, { "id": "NCT03013790_exc_T5", "type": "Observation", "text": [ "expected life expectancy" ], "offsets": [ [ 99, 123 ] ], "normalized": [] }, { "id": "NCT03013790_exc_T6", "type": "Value", "text": [ "<48 hours" ], "offsets": [ [ 124, 133 ] ], "normalized": [] }, { "id": "NCT03013790_exc_T7", "type": "Condition", "text": [ "Blind" ], "offsets": [ [ 134, 139 ] ], "normalized": [] }, { "id": "NCT03013790_exc_T8", "type": "Condition", "text": [ "seizure" ], "offsets": [ [ 165, 172 ] ], "normalized": [] }, { "id": "NCT03013790_exc_T9", "type": "Observation", "text": [ "history" ], "offsets": [ [ 173, 180 ] ], "normalized": [] }, { "id": "NCT03013790_exc_T10", "type": "Condition", "text": [ "uncontrolled hypertension" ], "offsets": [ [ 195, 220 ] ], "normalized": [] }, { "id": "NCT03013790_exc_T11", "type": "Value", "text": [ "supratheraputic" ], "offsets": [ [ 237, 252 ] ], "normalized": [] }, { "id": "NCT03013790_exc_T12", "type": "Value", "text": [ ">3.0" ], "offsets": [ [ 254, 258 ] ], "normalized": [] }, { "id": "NCT03013790_exc_T13", "type": "Measurement", "text": [ "INR" ], "offsets": [ [ 260, 263 ] ], "normalized": [] }, { "id": "NCT03013790_exc_T14", "type": "Drug", "text": [ "ciprofloxacin" ], "offsets": [ [ 302, 315 ] ], "normalized": [] }, { "id": "NCT03013790_exc_T15", "type": "Drug", "text": [ "fluvoxamine" ], "offsets": [ [ 317, 328 ] ], "normalized": [] }, { "id": "NCT03013790_exc_T16", "type": "Drug", "text": [ "methoxsalen" ], "offsets": [ [ 330, 341 ] ], "normalized": [] }, { "id": "NCT03013790_exc_T17", "type": "Drug", "text": [ "ofloxacin" ], "offsets": [ [ 343, 352 ] ], "normalized": [] }, { "id": "NCT03013790_exc_T18", "type": "Drug", "text": [ "primaquine" ], "offsets": [ [ 354, 364 ] ], "normalized": [] }, { "id": "NCT03013790_exc_T19", "type": "Drug", "text": [ "strong CYP1A2 inhibitors" ], "offsets": [ [ 276, 300 ] ], "normalized": [] }, { "id": "NCT03013790_exc_T20", "type": "Scope", "text": [ "ciprofloxacin, fluvoxamine, methoxsalen, ofloxacin, primaquine" ], "offsets": [ [ 302, 364 ] ], "normalized": [] }, { "id": "NCT03013790_exc_T21", "type": "Negation", "text": [ "not" ], "offsets": [ [ 381, 384 ] ], "normalized": [] }, { "id": "NCT03013790_exc_T22", "type": "Observation", "text": [ "speak English" ], "offsets": [ [ 385, 398 ] ], "normalized": [] }, { "id": "NCT03013790_exc_T23", "type": "Observation", "text": [ "glish", "" ], "offsets": [ [ 393, 398 ], [ 410, 410 ] ], "normalized": [] }, { "id": "NCT03013790_exc_T24", "type": "Scope", "text": [ "speak English or Spanish" ], "offsets": [ [ 385, 409 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03013790_exc_R1", "type": "Has_value", "arg1_id": "NCT03013790_exc_T4", "arg2_id": "NCT03013790_exc_T3", "normalized": [] }, { "id": "NCT03013790_exc_R2", "type": "Has_value", "arg1_id": "NCT03013790_exc_T5", "arg2_id": "NCT03013790_exc_T6", "normalized": [] }, { "id": "NCT03013790_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03013790_exc_T8", "arg2_id": "NCT03013790_exc_T9", "normalized": [] }, { "id": "NCT03013790_exc_R4", "type": "Subsumes", "arg1_id": "NCT03013790_exc_T11", "arg2_id": "NCT03013790_exc_T12", "normalized": [] }, { "id": "NCT03013790_exc_R5", "type": "Has_value", "arg1_id": "NCT03013790_exc_T13", "arg2_id": "NCT03013790_exc_T11", "normalized": [] }, { "id": "NCT03013790_exc_R6", "type": "Subsumes", "arg1_id": "NCT03013790_exc_T19", "arg2_id": "NCT03013790_exc_T20", "normalized": [] }, { "id": "NCT03013790_exc_R7", "type": "Has_negation", "arg1_id": "NCT03013790_exc_T24", "arg2_id": "NCT03013790_exc_T21", "normalized": [] } ]

[ { "id": "NCT03013790_inc_text", "type": "inclusion", "text": [ "Non-ventilated Patients over the age of 65\n" ], "offsets": [ [ 0, 43 ] ] } ]

[ { "id": "NCT03013790_inc_T1", "type": "Person", "text": [ "age" ], "offsets": [ [ 33, 36 ] ], "normalized": [] }, { "id": "NCT03013790_inc_T2", "type": "Value", "text": [ "over", "65" ], "offsets": [ [ 24, 28 ], [ 40, 42 ] ], "normalized": [] }, { "id": "NCT03013790_inc_T3", "type": "Procedure", "text": [ "ventilated" ], "offsets": [ [ 4, 14 ] ], "normalized": [] }, { "id": "NCT03013790_inc_T4", "type": "Negation", "text": [ "Non" ], "offsets": [ [ 0, 3 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03013790_inc_R1", "type": "Has_value", "arg1_id": "NCT03013790_inc_T1", "arg2_id": "NCT03013790_inc_T2", "normalized": [] }, { "id": "NCT03013790_inc_R2", "type": "Has_negation", "arg1_id": "NCT03013790_inc_T3", "arg2_id": "NCT03013790_inc_T4", "normalized": [] } ]

[ { "id": "NCT03015818_exc_text", "type": "exclusion", "text": [ "Inability to give informed consent\nPregnancy\nConcurrent antibiotherapy\nCertain infectious endocarditis\nConcurrent anti-inflammatory therapy, including corticosteroid therapy\n" ], "offsets": [ [ 0, 174 ] ] } ]

[ { "id": "NCT03015818_exc_T2", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 35, 44 ] ], "normalized": [] }, { "id": "NCT03015818_exc_T3", "type": "Drug", "text": [ "antibiotherapy" ], "offsets": [ [ 56, 70 ] ], "normalized": [] }, { "id": "NCT03015818_exc_T4", "type": "Temporal", "text": [ "Concurrent" ], "offsets": [ [ 45, 55 ] ], "normalized": [] }, { "id": "NCT03015818_exc_T5", "type": "Condition", "text": [ "infectious endocarditis" ], "offsets": [ [ 79, 102 ] ], "normalized": [] }, { "id": "NCT03015818_exc_T6", "type": "Qualifier", "text": [ "Certain" ], "offsets": [ [ 71, 78 ] ], "normalized": [] }, { "id": "NCT03015818_exc_T7", "type": "Temporal", "text": [ "Concurrent" ], "offsets": [ [ 103, 113 ] ], "normalized": [] }, { "id": "NCT03015818_exc_T8", "type": "Procedure", "text": [ "anti-inflammatory therapy" ], "offsets": [ [ 114, 139 ] ], "normalized": [] }, { "id": "NCT03015818_exc_T9", "type": "Drug", "text": [ "anti-inflammatory" ], "offsets": [ [ 114, 131 ] ], "normalized": [] }, { "id": "NCT03015818_exc_T10", "type": "Procedure", "text": [ "corticosteroid therapy" ], "offsets": [ [ 151, 173 ] ], "normalized": [] }, { "id": "NCT03015818_exc_T11", "type": "Drug", "text": [ "corticosteroid" ], "offsets": [ [ 151, 165 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03015818_exc_R1", "type": "Has_temporal", "arg1_id": "NCT03015818_exc_T3", "arg2_id": "NCT03015818_exc_T4", "normalized": [] }, { "id": "NCT03015818_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03015818_exc_T5", "arg2_id": "NCT03015818_exc_T6", "normalized": [] }, { "id": "NCT03015818_exc_R5", "type": "Subsumes", "arg1_id": "NCT03015818_exc_T8", "arg2_id": "NCT03015818_exc_T10", "normalized": [] }, { "id": "NCT03015818_exc_R6", "type": "Has_temporal", "arg1_id": "NCT03015818_exc_T8", "arg2_id": "NCT03015818_exc_T7", "normalized": [] } ]

[ { "id": "NCT03015818_inc_text", "type": "inclusion", "text": [ "age > 18\nwritten informed consent\nSVD defined on echocardiography by an alteration of bioprosthesis leaflets function with a mean transvalvular gradient > 20 mmHg and maximal velocity = 3 m/s and effective orifice area =1.2 cm², and/or an aortic regurgitation more or equal to grade 2 on 4.\n" ], "offsets": [ [ 0, 291 ] ] } ]

[ { "id": "NCT03015818_inc_T1", "type": "Person", "text": [ "age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03015818_inc_T2", "type": "Value", "text": [ "> 18" ], "offsets": [ [ 4, 8 ] ], "normalized": [] }, { "id": "NCT03015818_inc_T4", "type": "Condition", "text": [ "SVD" ], "offsets": [ [ 34, 37 ] ], "normalized": [] }, { "id": "NCT03015818_inc_T5", "type": "Procedure", "text": [ "echocardiography" ], "offsets": [ [ 49, 65 ] ], "normalized": [] }, { "id": "NCT03015818_inc_T6", "type": "Condition", "text": [ "alteration of bioprosthesis leaflets function" ], "offsets": [ [ 72, 117 ] ], "normalized": [] }, { "id": "NCT03015818_inc_T7", "type": "Measurement", "text": [ "mean transvalvular gradient" ], "offsets": [ [ 125, 152 ] ], "normalized": [] }, { "id": "NCT03015818_inc_T8", "type": "Value", "text": [ "> 20 mmHg" ], "offsets": [ [ 153, 162 ] ], "normalized": [] }, { "id": "NCT03015818_inc_T9", "type": "Measurement", "text": [ "maximal velocity" ], "offsets": [ [ 167, 183 ] ], "normalized": [] }, { "id": "NCT03015818_inc_T10", "type": "Value", "text": [ "= 3 m/s" ], "offsets": [ [ 184, 191 ] ], "normalized": [] }, { "id": "NCT03015818_inc_T11", "type": "Measurement", "text": [ "effective orifice area" ], "offsets": [ [ 196, 218 ] ], "normalized": [] }, { "id": "NCT03015818_inc_T12", "type": "Value", "text": [ "=1.2 cm²" ], "offsets": [ [ 219, 227 ] ], "normalized": [] }, { "id": "NCT03015818_inc_T13", "type": "Condition", "text": [ "aortic regurgitation" ], "offsets": [ [ 239, 259 ] ], "normalized": [] }, { "id": "NCT03015818_inc_T14", "type": "Value", "text": [ "re or equal to g", "on 4." ], "offsets": [ [ 262, 278 ], [ 285, 290 ] ], "normalized": [] }, { "id": "NCT03015818_inc_T15", "type": "Measurement", "text": [ "grade" ], "offsets": [ [ 277, 282 ] ], "normalized": [] }, { "id": "NCT03015818_inc_T16", "type": "Scope", "text": [ "mean transvalvular gradient > 20 mmHg and maximal velocity = 3 m/s and effective orifice area =1.2 cm²" ], "offsets": [ [ 125, 227 ] ], "normalized": [] }, { "id": "NCT03015818_inc_T17", "type": "Scope", "text": [ "alteration of bioprosthesis leaflets function with a mean transvalvular gradient > 20 mmHg and maximal velocity = 3 m/s and effective orifice area =1.2 cm², and/or an aortic regurgitation more or equal to grade 2 on 4" ], "offsets": [ [ 72, 289 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03015818_inc_R1", "type": "Has_value", "arg1_id": "NCT03015818_inc_T1", "arg2_id": "NCT03015818_inc_T2", "normalized": [] }, { "id": "NCT03015818_inc_R2", "type": "Has_value", "arg1_id": "NCT03015818_inc_T15", "arg2_id": "NCT03015818_inc_T14", "normalized": [] }, { "id": "NCT03015818_inc_R3", "type": "Has_value", "arg1_id": "NCT03015818_inc_T7", "arg2_id": "NCT03015818_inc_T8", "normalized": [] }, { "id": "NCT03015818_inc_R4", "type": "Has_value", "arg1_id": "NCT03015818_inc_T9", "arg2_id": "NCT03015818_inc_T10", "normalized": [] }, { "id": "NCT03015818_inc_R5", "type": "Has_value", "arg1_id": "NCT03015818_inc_T11", "arg2_id": "NCT03015818_inc_T12", "normalized": [] }, { "id": "NCT03015818_inc_R6", "type": "AND", "arg1_id": "NCT03015818_inc_T13", "arg2_id": "NCT03015818_inc_T15", "normalized": [] }, { "id": "NCT03015818_inc_R7", "type": "Has_scope", "arg1_id": "NCT03015818_inc_T6", "arg2_id": "NCT03015818_inc_T16", "normalized": [] }, { "id": "NCT03015818_inc_R8", "type": "AND", "arg1_id": "NCT03015818_inc_T4", "arg2_id": "NCT03015818_inc_T5", "normalized": [] }, { "id": "NCT03015818_inc_R9", "type": "Has_scope", "arg1_id": "NCT03015818_inc_T5", "arg2_id": "NCT03015818_inc_T17", "normalized": [] } ]

[ { "id": "NCT03016741_exc_text", "type": "exclusion", "text": [ "Prior treatment with enzalutamide or abiraterone acetate for > 14 days prior to enrollment and completion of baseline tests.\nReceipt of chemotherapy for prostate or other cancer within the past 12 months with residual cognitive deficits, or receipt of chemotherapy for mCRPC. Patients/physicians planning treatment with chemotherapy during the 12 month period of the investigation are also ineligible.\nHistory of cognitive impairment or dysfunction, including a history of dementia, Alzheimer's disease, stroke with residual cognitive deficits, cognitive dysfunction related to alcohol or substance abuse, or cognitive dysfunction related to prior treatment for any cancer.\nPatients with a seizure history, history of recurrent falls, or known brain metastases are excluded from this clinical trial because of their poor prognosis and because of their heightened risk of seizure or progressive cognitive and/or neurologic dysfunction that would confound the evaluation.\nUncontrolled intercurrent illness including, but not limited to, uncontrolled diabetes, ongoing or active infection, symptomatic congestive heart failure (New York Heart Association Class III and IV heart failure), unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations/substance abuse that would limit compliance with study requirements.\nPatients with a \"currently active\" second malignancy other than non-melanoma skin cancers are not eligible. Patients are not considered to have a \"currently active\" malignancy if they have completed all therapy and are now considered without evidence of disease for 1 year. Patients with cognitive dysfunction related to treatment of another malignancy, including a history of \"chemo-brain\", are ineligible.\nPatients taking psychotropic medications or illicit drugs that may alter cognition, concentration, or behavior. Appropriate treatment by a licensed provider with medications for depression or anxiety, including but not limited to SSRIs, SNRIs, and standard dose benzodiazepines at a stable dose, is permitted\n" ], "offsets": [ [ 0, 2058 ] ] } ]

[ { "id": "NCT03016741_exc_T1", "type": "Drug", "text": [ "enzalutamide" ], "offsets": [ [ 21, 33 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T2", "type": "Drug", "text": [ "abiraterone acetate" ], "offsets": [ [ 37, 56 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T3", "type": "Multiplier", "text": [ "for > 14 days" ], "offsets": [ [ 57, 70 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T4", "type": "Temporal", "text": [ "prior to enrollment" ], "offsets": [ [ 71, 90 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T5", "type": "Reference_point", "text": [ "enrollment" ], "offsets": [ [ 80, 90 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T6", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 6, 15 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T7", "type": "Scope", "text": [ "enzalutamide or abiraterone acetate" ], "offsets": [ [ 21, 56 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T8", "type": "Procedure", "text": [ "chemotherapy" ], "offsets": [ [ 136, 148 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T9", "type": "Condition", "text": [ "rostate", "ancer" ], "offsets": [ [ 154, 161 ], [ 172, 177 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T10", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 165, 170 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T11", "type": "Condition", "text": [ "cancer" ], "offsets": [ [ 171, 177 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T12", "type": "Scope", "text": [ "prostate or other cancer" ], "offsets": [ [ 153, 177 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T13", "type": "Temporal", "text": [ "within the past 12 months" ], "offsets": [ [ 178, 203 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T14", "type": "Condition", "text": [ "residual cognitive deficits" ], "offsets": [ [ 209, 236 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T15", "type": "Procedure", "text": [ "chemotherapy" ], "offsets": [ [ 252, 264 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T16", "type": "Condition", "text": [ "mCRPC" ], "offsets": [ [ 269, 274 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T18", "type": "Condition", "text": [ "cognitive impairment" ], "offsets": [ [ 413, 433 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T19", "type": "Condition", "text": [ "gnitive i", "sfunction," ], "offsets": [ [ 415, 424 ], [ 439, 449 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T20", "type": "Condition", "text": [ "dementia" ], "offsets": [ [ 473, 481 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T21", "type": "Condition", "text": [ "Alzheimer's disease" ], "offsets": [ [ 483, 502 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T22", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 504, 510 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T23", "type": "Condition", "text": [ "residual cognitive deficits" ], "offsets": [ [ 516, 543 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T24", "type": "Condition", "text": [ "cognitive dysfunction" ], "offsets": [ [ 545, 566 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T25", "type": "Condition", "text": [ "substance abuse" ], "offsets": [ [ 589, 604 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T26", "type": "Condition", "text": [ "cohol o", "use," ], "offsets": [ [ 580, 587 ], [ 601, 605 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T27", "type": "Scope", "text": [ "cognitive impairment or dysfunction" ], "offsets": [ [ 413, 448 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T28", "type": "Condition", "text": [ "cognitive dysfunction" ], "offsets": [ [ 609, 630 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T29", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 648, 657 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T30", "type": "Temporal", "text": [ "prior" ], "offsets": [ [ 642, 647 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T31", "type": "Condition", "text": [ "cancer" ], "offsets": [ [ 666, 672 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T32", "type": "Qualifier", "text": [ "any" ], "offsets": [ [ 662, 665 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T33", "type": "Scope", "text": [ "dementia, Alzheimer's disease, stroke with residual cognitive deficits, cognitive dysfunction related to alcohol or substance abuse, or cognitive dysfunction related to prior treatment for any cancer" ], "offsets": [ [ 473, 672 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T34", "type": "Condition", "text": [ "seizure" ], "offsets": [ [ 690, 697 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T35", "type": "Condition", "text": [ "recurrent falls" ], "offsets": [ [ 718, 733 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T36", "type": "Condition", "text": [ "brain metastases" ], "offsets": [ [ 744, 760 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T37", "type": "Observation", "text": [ "history" ], "offsets": [ [ 698, 705 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T38", "type": "Observation", "text": [ "history of" ], "offsets": [ [ 707, 717 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T39", "type": "Condition", "text": [ "intercurrent illness" ], "offsets": [ [ 983, 1003 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T40", "type": "Qualifier", "text": [ "Uncontrolled" ], "offsets": [ [ 970, 982 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T41", "type": "Qualifier", "text": [ "uncontrolled" ], "offsets": [ [ 1035, 1047 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T42", "type": "Condition", "text": [ "diabetes" ], "offsets": [ [ 1048, 1056 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T43", "type": "Temporal", "text": [ "ongoing" ], "offsets": [ [ 1058, 1065 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T44", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 1069, 1075 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T45", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 1076, 1085 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T46", "type": "Scope", "text": [ "ongoing or active" ], "offsets": [ [ 1058, 1075 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T47", "type": "Qualifier", "text": [ "symptomatic" ], "offsets": [ [ 1087, 1098 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T48", "type": "Condition", "text": [ "congestive heart failure" ], "offsets": [ [ 1099, 1123 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T49", "type": "Measurement", "text": [ "New York Heart Association" ], "offsets": [ [ 1125, 1151 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T50", "type": "Value", "text": [ "Class III and IV" ], "offsets": [ [ 1152, 1168 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T51", "type": "Condition", "text": [ "heart failure" ], "offsets": [ [ 1169, 1182 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T52", "type": "Scope", "text": [ "New York Heart Association Class III and IV heart failure" ], "offsets": [ [ 1125, 1182 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T53", "type": "Scope", "text": [ "symptomatic congestive heart failure" ], "offsets": [ [ 1087, 1123 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T54", "type": "Condition", "text": [ "unstable angina pectoris" ], "offsets": [ [ 1185, 1209 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T55", "type": "Condition", "text": [ "cardiac arrhythmia" ], "offsets": [ [ 1211, 1229 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T56", "type": "Condition", "text": [ "psychiatric illness" ], "offsets": [ [ 1234, 1253 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T57", "type": "Condition", "text": [ "social situations" ], "offsets": [ [ 1254, 1271 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T58", "type": "Condition", "text": [ "substance abuse" ], "offsets": [ [ 1272, 1287 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T59", "type": "Scope", "text": [ "uncontrolled diabetes, ongoing or active infection, symptomatic congestive heart failure (New York Heart Association Class III and IV heart failure), unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations/substance abuse" ], "offsets": [ [ 1035, 1287 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T60", "type": "Scope", "text": [ "Uncontrolled intercurrent illness" ], "offsets": [ [ 970, 1003 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T61", "type": "Multiplier", "text": [ "second" ], "offsets": [ [ 1376, 1382 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T62", "type": "Condition", "text": [ "malignancy" ], "offsets": [ [ 1383, 1393 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T63", "type": "Qualifier", "text": [ "currently active" ], "offsets": [ [ 1358, 1374 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T64", "type": "Condition", "text": [ "non-melanoma skin cancers" ], "offsets": [ [ 1405, 1430 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T65", "type": "Negation", "text": [ "other than" ], "offsets": [ [ 1394, 1404 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T66", "type": "Condition", "text": [ "cognitive dysfunction" ], "offsets": [ [ 1629, 1650 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T67", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 1662, 1671 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T68", "type": "Qualifier", "text": [ "another" ], "offsets": [ [ 1675, 1682 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T69", "type": "Condition", "text": [ "malignancy" ], "offsets": [ [ 1683, 1693 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T70", "type": "Drug", "text": [ "psychotropic medications" ], "offsets": [ [ 1765, 1789 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T71", "type": "Drug", "text": [ "illicit drugs" ], "offsets": [ [ 1793, 1806 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T72", "type": "Condition", "text": [ "alter cognition" ], "offsets": [ [ 1816, 1831 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T73", "type": "Condition", "text": [ "cogni", "tration, or b" ], "offsets": [ [ 1822, 1827 ], [ 1839, 1852 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T74", "type": "Condition", "text": [ "cogni", "or. Appr" ], "offsets": [ [ 1822, 1827 ], [ 1857, 1865 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T75", "type": "Scope", "text": [ "psychotropic medications or illicit drugs" ], "offsets": [ [ 1765, 1806 ] ], "normalized": [] }, { "id": "NCT03016741_exc_T76", "type": "Scope", "text": [ "alter cognition, concentration, or behavior" ], "offsets": [ [ 1816, 1859 ] ], "normalized": [] } ]

[]

[]

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[ { "id": "NCT03016741_inc_text", "type": "inclusion", "text": [ "Have diagnosis of prostate cancer and have received treatment with GnRH agonist or antagonist therapy for at least 1 month prior to enrollment.\nWilling and able to complete survey questionnaires in English without assistance through the duration of the study. This stipulation is in place because not all of the proposed quality of life or cognitive tests are available or validated in other languages.\nAge = 18 years.\nAbility to understand and the willingness to sign a written informed consent document written in English that is approved by an institutional review board.\nHave either newly diagnosed metastatic hormone sensitive prostate cancer (mHSPC) or castration-resistant metastatic prostate cancer (mCRPC) and eligible to undergo treatment with abiraterone acetate (mHSPC or mCRPC) or enzalutamide (mCRPC)\nPatients may have received the following prior AR directed therapy prior to enrollment: bicalutamide, ketoconazole. Prior to enrollment, patients may have received treatment with abiraterone acetate or enzalutamide for no more than 14 days before completing baseline studies.\nPatients may have received chemotherapy for hormone-sensitive metastatic prostate cancer only, but it must not have lasted for more than 6 months. At least 12 months must have elapsed since completion of chemotherapy.\nPatients may have received prior definitive radiation therapy or surgery. At least 60 days must have elapsed since completion of definitive radiation therapy or surgery and patient must have only grade 2 or less adverse effects at the time of registration. Enrollment during palliative radiation of = 10 days, or radiation of = 10 days during the duration of the study is allowed.\nPatients must be able to take oral medication.\n" ], "offsets": [ [ 0, 1737 ] ] } ]

[ { "id": "NCT03016741_inc_T1", "type": "Condition", "text": [ "prostate cancer" ], "offsets": [ [ 18, 33 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T2", "type": "Drug", "text": [ "GnRH agonist" ], "offsets": [ [ 67, 79 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T3", "type": "Drug", "text": [ "GnRH", "antagonist" ], "offsets": [ [ 67, 71 ], [ 83, 93 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T4", "type": "Multiplier", "text": [ "for at least 1 month" ], "offsets": [ [ 102, 122 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T5", "type": "Temporal", "text": [ "prior to enrollment" ], "offsets": [ [ 123, 142 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T6", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 52, 61 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T7", "type": "Scope", "text": [ "GnRH agonist or antagonist" ], "offsets": [ [ 67, 93 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T9", "type": "Person", "text": [ "Age" ], "offsets": [ [ 403, 406 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T10", "type": "Value", "text": [ "= 18 years" ], "offsets": [ [ 407, 417 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T12", "type": "Qualifier", "text": [ "metastatic" ], "offsets": [ [ 603, 613 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T13", "type": "Qualifier", "text": [ "hormone sensitive" ], "offsets": [ [ 614, 631 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T14", "type": "Condition", "text": [ "prostate cancer" ], "offsets": [ [ 632, 647 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T15", "type": "Condition", "text": [ "mHSPC" ], "offsets": [ [ 649, 654 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T16", "type": "Scope", "text": [ "metastatic hormone sensitive prostate cancer" ], "offsets": [ [ 603, 647 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T17", "type": "Qualifier", "text": [ "castration-resistant" ], "offsets": [ [ 659, 679 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T18", "type": "Qualifier", "text": [ "metastatic" ], "offsets": [ [ 680, 690 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T19", "type": "Condition", "text": [ "prostate cancer" ], "offsets": [ [ 691, 706 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T20", "type": "Condition", "text": [ "mCRPC" ], "offsets": [ [ 708, 713 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T21", "type": "Scope", "text": [ "castration-resistant metastatic prostate cancer" ], "offsets": [ [ 659, 706 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T22", "type": "Drug", "text": [ "abiraterone acetate" ], "offsets": [ [ 754, 773 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T23", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 739, 748 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T24", "type": "Condition", "text": [ "mHSPC" ], "offsets": [ [ 775, 780 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T25", "type": "Condition", "text": [ "mCRPC" ], "offsets": [ [ 784, 789 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T26", "type": "Drug", "text": [ "enzalutamide" ], "offsets": [ [ 794, 806 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T27", "type": "Condition", "text": [ "mCRPC" ], "offsets": [ [ 808, 813 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T28", "type": "Scope", "text": [ "abiraterone acetate (mHSPC or mCRPC) or enzalutamide (mCRPC" ], "offsets": [ [ 754, 813 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T29", "type": "Scope", "text": [ "enzalutamide (mCRPC)" ], "offsets": [ [ 794, 814 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T30", "type": "Scope", "text": [ "abiraterone acetate (mHSPC or mCRPC)" ], "offsets": [ [ 754, 790 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T31", "type": "Scope", "text": [ "castration-resistant metastatic prostate cancer (mCRPC) and eligible to undergo treatment with abiraterone acetate (mHSPC or mCRPC) or enzalutamide (mCRPC)" ], "offsets": [ [ 659, 814 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T32", "type": "Procedure", "text": [ "chemotherapy" ], "offsets": [ [ 1118, 1130 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T33", "type": "Qualifier", "text": [ "hormone-sensitive" ], "offsets": [ [ 1135, 1152 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T34", "type": "Qualifier", "text": [ "metastatic" ], "offsets": [ [ 1153, 1163 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T35", "type": "Condition", "text": [ "prostate cancer" ], "offsets": [ [ 1164, 1179 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T36", "type": "Multiplier", "text": [ "lasted for more than 6 months" ], "offsets": [ [ 1207, 1236 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T37", "type": "Negation", "text": [ "not" ], "offsets": [ [ 1198, 1201 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T38", "type": "Temporal", "text": [ "At least 12 months must have elapsed since completion of chemotherapy" ], "offsets": [ [ 1238, 1307 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T39", "type": "Reference_point", "text": [ "completion of chemotherapy" ], "offsets": [ [ 1281, 1307 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T40", "type": "Procedure", "text": [ "chemotherapy" ], "offsets": [ [ 1295, 1307 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T41", "type": "Temporal", "text": [ "prior" ], "offsets": [ [ 1336, 1341 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T42", "type": "Qualifier", "text": [ "definitive" ], "offsets": [ [ 1342, 1352 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T43", "type": "Procedure", "text": [ "radiation therapy" ], "offsets": [ [ 1353, 1370 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T44", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 1374, 1381 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T45", "type": "Scope", "text": [ "radiation therapy or surgery" ], "offsets": [ [ 1353, 1381 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T46", "type": "Temporal", "text": [ "At least 60 days must have elapsed since completion of definitive radiation therapy or surgery" ], "offsets": [ [ 1383, 1477 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T47", "type": "Procedure", "text": [ "radiation therapy" ], "offsets": [ [ 1449, 1466 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T48", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 1470, 1477 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T49", "type": "Qualifier", "text": [ "definitive" ], "offsets": [ [ 1438, 1448 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T50", "type": "Reference_point", "text": [ "completion of definitive radiation therapy or surgery" ], "offsets": [ [ 1424, 1477 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T51", "type": "Qualifier", "text": [ "grade 2 or less" ], "offsets": [ [ 1505, 1520 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T52", "type": "Condition", "text": [ "adverse effects" ], "offsets": [ [ 1521, 1536 ] ], "normalized": [] }, { "id": "NCT03016741_inc_T53", "type": "Temporal", "text": [ "at the time of registration" ], "offsets": [ [ 1537, 1564 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03016741_inc_R1", "type": "Has_scope", "arg1_id": "NCT03016741_inc_T6", "arg2_id": "NCT03016741_inc_T7", "normalized": [] }, { "id": "NCT03016741_inc_R2", "type": "Has_multiplier", "arg1_id": "NCT03016741_inc_T6", "arg2_id": "NCT03016741_inc_T4", "normalized": [] }, { "id": "NCT03016741_inc_R3", "type": "Has_temporal", "arg1_id": "NCT03016741_inc_T6", "arg2_id": "NCT03016741_inc_T5", "normalized": [] }, { "id": "NCT03016741_inc_R4", "type": "Has_value", "arg1_id": "NCT03016741_inc_T9", "arg2_id": "NCT03016741_inc_T10", "normalized": [] }, { "id": "NCT03016741_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT03016741_inc_T14", "arg2_id": "NCT03016741_inc_T13", "normalized": [] }, { "id": "NCT03016741_inc_R6", "type": "Has_qualifier", "arg1_id": "NCT03016741_inc_T14", "arg2_id": "NCT03016741_inc_T12", "normalized": [] }, { "id": "NCT03016741_inc_R7", "type": "Subsumes", "arg1_id": "NCT03016741_inc_T15", "arg2_id": "NCT03016741_inc_T16", "normalized": [] }, { "id": "NCT03016741_inc_R8", "type": "Has_qualifier", "arg1_id": "NCT03016741_inc_T19", "arg2_id": "NCT03016741_inc_T18", "normalized": [] }, { "id": "NCT03016741_inc_R9", "type": "Has_qualifier", "arg1_id": "NCT03016741_inc_T19", "arg2_id": "NCT03016741_inc_T17", "normalized": [] }, { "id": "NCT03016741_inc_R10", "type": "Subsumes", "arg1_id": "NCT03016741_inc_T20", "arg2_id": "NCT03016741_inc_T21", "normalized": [] }, { "id": "NCT03016741_inc_R11", "type": "Has_scope", "arg1_id": "NCT03016741_inc_T23", "arg2_id": "NCT03016741_inc_T28", "normalized": [] }, { "id": "NCT03016741_inc_R12", "type": "Has_qualifier", "arg1_id": "NCT03016741_inc_T35", "arg2_id": "NCT03016741_inc_T34", "normalized": [] }, { "id": "NCT03016741_inc_R13", "type": "Has_qualifier", "arg1_id": "NCT03016741_inc_T35", "arg2_id": "NCT03016741_inc_T33", "normalized": [] }, { "id": "NCT03016741_inc_R14", "type": "AND", "arg1_id": "NCT03016741_inc_T32", "arg2_id": "NCT03016741_inc_T35", "normalized": [] }, { "id": "NCT03016741_inc_R15", "type": "Has_negation", "arg1_id": "NCT03016741_inc_T36", "arg2_id": "NCT03016741_inc_T37", "normalized": [] }, { "id": "NCT03016741_inc_R16", "type": "Has_multiplier", "arg1_id": "NCT03016741_inc_T32", "arg2_id": "NCT03016741_inc_T36", "normalized": [] }, { "id": "NCT03016741_inc_R18", "type": "Has_index", "arg1_id": "NCT03016741_inc_T38", "arg2_id": "NCT03016741_inc_T39", "normalized": [] }, { "id": "NCT03016741_inc_R19", "type": "Has_temporal", "arg1_id": "NCT03016741_inc_T32", "arg2_id": "NCT03016741_inc_T38", "normalized": [] }, { "id": "NCT03016741_inc_R20", "type": "Has_qualifier", "arg1_id": "NCT03016741_inc_T45", "arg2_id": "NCT03016741_inc_T42", "normalized": [] }, { "id": "NCT03016741_inc_R21", "type": "Has_temporal", "arg1_id": "NCT03016741_inc_T45", "arg2_id": "NCT03016741_inc_T41", "normalized": [] }, { "id": "NCT03016741_inc_R22", "type": "Has_index", "arg1_id": "NCT03016741_inc_T46", "arg2_id": "NCT03016741_inc_T50", "normalized": [] }, { "id": "NCT03016741_inc_R23", "type": "Has_qualifier", "arg1_id": "NCT03016741_inc_T52", "arg2_id": "NCT03016741_inc_T51", "normalized": [] }, { "id": "NCT03016741_inc_R24", "type": "Has_temporal", "arg1_id": "NCT03016741_inc_T52", "arg2_id": "NCT03016741_inc_T53", "normalized": [] }, { "id": "NCT03016741_inc_R25", "type": "Has_temporal", "arg1_id": "NCT03016741_inc_T45", "arg2_id": "NCT03016741_inc_T46", "normalized": [] } ]

[ { "id": "NCT03017053_exc_text", "type": "exclusion", "text": [ "Inability to provide an informed consent\nEvidence of oral distant metastasis or other malignancies\nThe patient has received prior surgery for primary tumor or lymph node ( except for biopsy )\nPrior radiotherapy for primary tumor\nThe patient has previously received anti-tumor biological targeted therapy\nThe patient has received chemotherapy or immunotherapy for primary tumors\nPrior malignancy within the previous 5 years (except for cured skin basal cell carcinoma or cervical carcinoma in situ)\nWith 3-4 grad Allergy to any drug in the treatment\nPeripheral neuropathy> 1 grade\nAny unstable systematic disease (including active infection, uncontrolled high blood pressure, unstable angina, onset of angina within the last 3 months, congestive heart failure, myocardial infarction within the previous 12 months, severe arrhythmia needing drug treatment, liver, kidney or metabolic disease)\nHIV positive\nChronic diseases requiring immune agents or hormone therapy\nPregnant or lactating women\nDrug/alcohol abuse, psychological or spiritual illness that may interfere compliance to the study\nPatients with epilepsy requiring medications (such as steroids or antiepileptic drugs)\nThe patient has participated in other experimental therapy studies within 30 days\nResearchers believe that the situation is unsuitable for participation in the group\n" ], "offsets": [ [ 0, 1343 ] ] } ]

[ { "id": "NCT03017053_exc_T2", "type": "Qualifier", "text": [ "distant" ], "offsets": [ [ 58, 65 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T3", "type": "Qualifier", "text": [ "oral" ], "offsets": [ [ 53, 57 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T4", "type": "Condition", "text": [ "metastasis" ], "offsets": [ [ 66, 76 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T5", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 80, 85 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T6", "type": "Condition", "text": [ "malignancies" ], "offsets": [ [ 86, 98 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T7", "type": "Temporal", "text": [ "prior" ], "offsets": [ [ 124, 129 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T8", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 130, 137 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T9", "type": "Qualifier", "text": [ "primary" ], "offsets": [ [ 142, 149 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T10", "type": "Condition", "text": [ "tumor" ], "offsets": [ [ 150, 155 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T11", "type": "Condition", "text": [ "lymph node" ], "offsets": [ [ 159, 169 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T12", "type": "Scope", "text": [ "tumor or lymph node" ], "offsets": [ [ 150, 169 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T13", "type": "Procedure", "text": [ "biopsy" ], "offsets": [ [ 183, 189 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T14", "type": "Negation", "text": [ "except for" ], "offsets": [ [ 172, 182 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T15", "type": "Scope", "text": [ "except for biopsy" ], "offsets": [ [ 172, 189 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T16", "type": "Procedure", "text": [ "radiotherapy" ], "offsets": [ [ 198, 210 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T17", "type": "Temporal", "text": [ "Prior" ], "offsets": [ [ 192, 197 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T18", "type": "Qualifier", "text": [ "primary" ], "offsets": [ [ 215, 222 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T19", "type": "Condition", "text": [ "tumor" ], "offsets": [ [ 223, 228 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T20", "type": "Procedure", "text": [ "anti-tumor biological targeted therapy" ], "offsets": [ [ 265, 303 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T21", "type": "Temporal", "text": [ "previously" ], "offsets": [ [ 245, 255 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T22", "type": "Procedure", "text": [ "chemotherapy" ], "offsets": [ [ 329, 341 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T23", "type": "Procedure", "text": [ "immunotherapy" ], "offsets": [ [ 345, 358 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T24", "type": "Condition", "text": [ "primary tumors" ], "offsets": [ [ 363, 377 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T25", "type": "Scope", "text": [ "chemotherapy or immunotherapy" ], "offsets": [ [ 329, 358 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T26", "type": "Condition", "text": [ "malignancy" ], "offsets": [ [ 384, 394 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T27", "type": "Temporal", "text": [ "Prior" ], "offsets": [ [ 378, 383 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T28", "type": "Temporal", "text": [ "within the previous 5 years" ], "offsets": [ [ 395, 422 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T29", "type": "Condition", "text": [ "cured skin basal cell carcinoma" ], "offsets": [ [ 435, 466 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T30", "type": "Condition", "text": [ "cervical carcinoma in situ" ], "offsets": [ [ 470, 496 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T31", "type": "Negation", "text": [ "except for" ], "offsets": [ [ 424, 434 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T32", "type": "Scope", "text": [ "cured skin basal cell carcinoma or cervical carcinoma in situ" ], "offsets": [ [ 435, 496 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T33", "type": "Qualifier", "text": [ "3-4 grad" ], "offsets": [ [ 503, 511 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T34", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 512, 519 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T35", "type": "Drug", "text": [ "drug" ], "offsets": [ [ 527, 531 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T36", "type": "Qualifier", "text": [ "any" ], "offsets": [ [ 523, 526 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T37", "type": "Condition", "text": [ "Peripheral neuropathy" ], "offsets": [ [ 549, 570 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T38", "type": "Qualifier", "text": [ "> 1 grade" ], "offsets": [ [ 570, 579 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T39", "type": "Condition", "text": [ "systematic disease" ], "offsets": [ [ 593, 611 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T40", "type": "Qualifier", "text": [ "unstable" ], "offsets": [ [ 584, 592 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T41", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 630, 639 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T42", "type": "Condition", "text": [ "high blood pressure" ], "offsets": [ [ 654, 673 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T43", "type": "Qualifier", "text": [ "uncontrolled" ], "offsets": [ [ 641, 653 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T44", "type": "Condition", "text": [ "unstable angina" ], "offsets": [ [ 675, 690 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T45", "type": "Temporal", "text": [ "within the last 3 months" ], "offsets": [ [ 708, 732 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T46", "type": "Measurement", "text": [ "onset" ], "offsets": [ [ 692, 697 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T47", "type": "Condition", "text": [ "angina" ], "offsets": [ [ 701, 707 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T48", "type": "Condition", "text": [ "congestive heart failure" ], "offsets": [ [ 734, 758 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T49", "type": "Condition", "text": [ "myocardial infarction" ], "offsets": [ [ 760, 781 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T50", "type": "Temporal", "text": [ "within the previous 12 months" ], "offsets": [ [ 782, 811 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T51", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 813, 819 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T52", "type": "Condition", "text": [ "arrhythmia" ], "offsets": [ [ 820, 830 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T53", "type": "Drug", "text": [ "drug" ], "offsets": [ [ 839, 843 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T54", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 844, 853 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T55", "type": "Condition", "text": [ "metabolic disease" ], "offsets": [ [ 872, 889 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T56", "type": "Condition", "text": [ " meta", "HIV pos" ], "offsets": [ [ 871, 876 ], [ 891, 898 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T57", "type": "Condition", "text": [ "dney", "HIV pos" ], "offsets": [ [ 864, 868 ], [ 891, 898 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T58", "type": "Scope", "text": [ "infection, uncontrolled high blood pressure, unstable angina, onset of angina within the last 3 months, congestive heart failure, myocardial infarction within the previous 12 months, severe arrhythmia needing drug treatment, liver, kidney or metabolic disease" ], "offsets": [ [ 630, 889 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T59", "type": "Scope", "text": [ "unstable systematic disease" ], "offsets": [ [ 584, 611 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T60", "type": "Condition", "text": [ "HIV positive" ], "offsets": [ [ 891, 903 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T61", "type": "Condition", "text": [ "Chronic diseases" ], "offsets": [ [ 904, 920 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T62", "type": "Drug", "text": [ "immune agents" ], "offsets": [ [ 931, 944 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T63", "type": "Procedure", "text": [ "hormone therapy" ], "offsets": [ [ 948, 963 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T64", "type": "Scope", "text": [ "immune agents or hormone therapy" ], "offsets": [ [ 931, 963 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T65", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 964, 972 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T66", "type": "Condition", "text": [ "lactating" ], "offsets": [ [ 976, 985 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T67", "type": "Person", "text": [ "women" ], "offsets": [ [ 986, 991 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T69", "type": "Condition", "text": [ "epilepsy" ], "offsets": [ [ 1104, 1112 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T70", "type": "Drug", "text": [ "medications" ], "offsets": [ [ 1123, 1134 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T71", "type": "Drug", "text": [ "steroids" ], "offsets": [ [ 1144, 1152 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T72", "type": "Drug", "text": [ "antiepileptic drugs" ], "offsets": [ [ 1156, 1175 ] ], "normalized": [] }, { "id": "NCT03017053_exc_T73", "type": "Scope", "text": [ "steroids or antiepileptic drugs" ], "offsets": [ [ 1144, 1175 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03017053_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03017053_exc_T6", "arg2_id": "NCT03017053_exc_T5", "normalized": [] }, { "id": "NCT03017053_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03017053_exc_T4", "arg2_id": "NCT03017053_exc_T2", "normalized": [] }, { "id": "NCT03017053_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03017053_exc_T4", "arg2_id": "NCT03017053_exc_T3", "normalized": [] }, { "id": "NCT03017053_exc_R4", "type": "Has_temporal", "arg1_id": "NCT03017053_exc_T8", "arg2_id": "NCT03017053_exc_T7", "normalized": [] }, { "id": "NCT03017053_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT03017053_exc_T12", "arg2_id": "NCT03017053_exc_T9", "normalized": [] }, { "id": "NCT03017053_exc_R6", "type": "Has_scope", "arg1_id": "NCT03017053_exc_T8", "arg2_id": "NCT03017053_exc_T12", "normalized": [] }, { "id": "NCT03017053_exc_R7", "type": "Has_negation", "arg1_id": "NCT03017053_exc_T13", "arg2_id": "NCT03017053_exc_T14", "normalized": [] }, { "id": "NCT03017053_exc_R8", "type": "Subsumes", "arg1_id": "NCT03017053_exc_T8", "arg2_id": "NCT03017053_exc_T15", "normalized": [] }, { "id": "NCT03017053_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT03017053_exc_T19", "arg2_id": "NCT03017053_exc_T18", "normalized": [] }, { "id": "NCT03017053_exc_R10", "type": "Has_temporal", "arg1_id": "NCT03017053_exc_T16", "arg2_id": "NCT03017053_exc_T17", "normalized": [] }, { "id": "NCT03017053_exc_R11", "type": "AND", "arg1_id": "NCT03017053_exc_T16", "arg2_id": "NCT03017053_exc_T19", "normalized": [] }, { "id": "NCT03017053_exc_R12", "type": "Has_temporal", "arg1_id": "NCT03017053_exc_T20", "arg2_id": "NCT03017053_exc_T21", "normalized": [] }, { "id": "NCT03017053_exc_R13", "type": "AND", "arg1_id": "NCT03017053_exc_T25", "arg2_id": "NCT03017053_exc_T24", "normalized": [] }, { "id": "NCT03017053_exc_R14", "type": "Has_temporal", "arg1_id": "NCT03017053_exc_T26", "arg2_id": "NCT03017053_exc_T27", "normalized": [] }, { "id": "NCT03017053_exc_R15", "type": "Has_temporal", "arg1_id": "NCT03017053_exc_T26", "arg2_id": "NCT03017053_exc_T28", "normalized": [] }, { "id": "NCT03017053_exc_R16", "type": "Has_negation", "arg1_id": "NCT03017053_exc_T32", "arg2_id": "NCT03017053_exc_T31", "normalized": [] }, { "id": "NCT03017053_exc_R17", "type": "Has_scope", "arg1_id": "NCT03017053_exc_T26", "arg2_id": "NCT03017053_exc_T32", "normalized": [] }, { "id": "NCT03017053_exc_R18", "type": "Has_qualifier", "arg1_id": "NCT03017053_exc_T35", "arg2_id": "NCT03017053_exc_T36", "normalized": [] }, { "id": "NCT03017053_exc_R19", "type": "AND", "arg1_id": "NCT03017053_exc_T34", "arg2_id": "NCT03017053_exc_T35", "normalized": [] }, { "id": "NCT03017053_exc_R20", "type": "Has_qualifier", "arg1_id": "NCT03017053_exc_T34", "arg2_id": "NCT03017053_exc_T33", "normalized": [] }, { "id": "NCT03017053_exc_R21", "type": "Has_qualifier", "arg1_id": "NCT03017053_exc_T37", "arg2_id": "NCT03017053_exc_T38", "normalized": [] }, { "id": "NCT03017053_exc_R22", "type": "Has_qualifier", "arg1_id": "NCT03017053_exc_T39", "arg2_id": "NCT03017053_exc_T40", "normalized": [] }, { "id": "NCT03017053_exc_R23", "type": "Has_temporal", "arg1_id": "NCT03017053_exc_T46", "arg2_id": "NCT03017053_exc_T45", "normalized": [] }, { "id": "NCT03017053_exc_R24", "type": "AND", "arg1_id": "NCT03017053_exc_T47", "arg2_id": "NCT03017053_exc_T46", "normalized": [] }, { "id": "NCT03017053_exc_R25", "type": "Has_qualifier", "arg1_id": "NCT03017053_exc_T42", "arg2_id": "NCT03017053_exc_T43", "normalized": [] }, { "id": "NCT03017053_exc_R26", "type": "AND", "arg1_id": "NCT03017053_exc_T54", "arg2_id": "NCT03017053_exc_T53", "normalized": [] }, { "id": "NCT03017053_exc_R27", "type": "AND", "arg1_id": "NCT03017053_exc_T52", "arg2_id": "NCT03017053_exc_T54", "normalized": [] }, { "id": "NCT03017053_exc_R28", "type": "Has_qualifier", "arg1_id": "NCT03017053_exc_T52", "arg2_id": "NCT03017053_exc_T51", "normalized": [] }, { "id": "NCT03017053_exc_R29", "type": "Has_temporal", "arg1_id": "NCT03017053_exc_T49", "arg2_id": "NCT03017053_exc_T50", "normalized": [] }, { "id": "NCT03017053_exc_R30", "type": "Subsumes", "arg1_id": "NCT03017053_exc_T59", "arg2_id": "NCT03017053_exc_T58", "normalized": [] }, { "id": "NCT03017053_exc_R31", "type": "Has_scope", "arg1_id": "NCT03017053_exc_T61", "arg2_id": "NCT03017053_exc_T64", "normalized": [] }, { "id": "NCT03017053_exc_R32", "type": "AND", "arg1_id": "NCT03017053_exc_T69", "arg2_id": "NCT03017053_exc_T70", "normalized": [] }, { "id": "NCT03017053_exc_R33", "type": "Subsumes", "arg1_id": "NCT03017053_exc_T70", "arg2_id": "NCT03017053_exc_T73", "normalized": [] } ]

[ { "id": "NCT03017053_inc_text", "type": "inclusion", "text": [ "Ability to understand and the willingness to sign a written informed consent document\nAge= 18 and= 75 years\nClinical/ Histological/ cytological/ Imaging examination proven Oral/Oropharynx Squamous-cell carcinoma (Tongue, buccal mucosa, mouth floor, hard palate, Molar area), the depth of invasion > 4mm in preoperative assessment\nIn line with clinical stage I / II stage (T1-2 N0 M0; AJCC 2010) and receiving surgical resection\nKPS= 70\nNormal bone marrow reserve function and normal liver, kidney function\nExpected survival period= 6 months\n" ], "offsets": [ [ 0, 541 ] ] } ]

[ { "id": "NCT03017053_inc_T2", "type": "Person", "text": [ "Age" ], "offsets": [ [ 86, 89 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T3", "type": "Value", "text": [ "= 18 and= 75 years" ], "offsets": [ [ 89, 107 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T4", "type": "Condition", "text": [ "Squamous-cell carcinoma" ], "offsets": [ [ 188, 211 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T5", "type": "Qualifier", "text": [ "Oropharynx" ], "offsets": [ [ 177, 187 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T6", "type": "Qualifier", "text": [ "Oral" ], "offsets": [ [ 172, 176 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T7", "type": "Scope", "text": [ "Oral/Oropharynx" ], "offsets": [ [ 172, 187 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T8", "type": "Qualifier", "text": [ "Tongue" ], "offsets": [ [ 213, 219 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T9", "type": "Qualifier", "text": [ "buccal mucosa" ], "offsets": [ [ 221, 234 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T10", "type": "Qualifier", "text": [ "mouth floor" ], "offsets": [ [ 236, 247 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T11", "type": "Qualifier", "text": [ "hard palate" ], "offsets": [ [ 249, 260 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T12", "type": "Qualifier", "text": [ "Molar area" ], "offsets": [ [ 262, 272 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T13", "type": "Scope", "text": [ "Tongue, buccal mucosa, mouth floor, hard palate, Molar area" ], "offsets": [ [ 213, 272 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T14", "type": "Measurement", "text": [ "depth of invasion" ], "offsets": [ [ 279, 296 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T15", "type": "Value", "text": [ "> 4mm" ], "offsets": [ [ 297, 302 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T16", "type": "Procedure", "text": [ "preoperative assessment" ], "offsets": [ [ 306, 329 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T17", "type": "Procedure", "text": [ "inical/", "amination p" ], "offsets": [ [ 110, 117 ], [ 155, 166 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T18", "type": "Procedure", "text": [ "stological/", "amination p" ], "offsets": [ [ 120, 131 ], [ 155, 166 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T19", "type": "Procedure", "text": [ "tological/", "amination p" ], "offsets": [ [ 134, 144 ], [ 155, 166 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T20", "type": "Procedure", "text": [ "Imaging examination" ], "offsets": [ [ 145, 164 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T21", "type": "Scope", "text": [ "Clinical/ Histological/ cytological/ Imaging examination" ], "offsets": [ [ 108, 164 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T22", "type": "Procedure", "text": [ "surgical resection" ], "offsets": [ [ 409, 427 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T23", "type": "Condition", "text": [ "clinical stage I" ], "offsets": [ [ 343, 359 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T24", "type": "Condition", "text": [ "nical stage I", "st" ], "offsets": [ [ 346, 359 ], [ 365, 367 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T25", "type": "Measurement", "text": [ "T" ], "offsets": [ [ 372, 373 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T26", "type": "Value", "text": [ "1-2" ], "offsets": [ [ 373, 376 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T27", "type": "Measurement", "text": [ "N" ], "offsets": [ [ 377, 378 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T28", "type": "Value", "text": [ "0" ], "offsets": [ [ 381, 382 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T29", "type": "Measurement", "text": [ "M" ], "offsets": [ [ 380, 381 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T30", "type": "Value", "text": [ "0" ], "offsets": [ [ 381, 382 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T31", "type": "Scope", "text": [ "T1-2 N0 M0" ], "offsets": [ [ 372, 382 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T32", "type": "Scope", "text": [ "clinical stage I / II" ], "offsets": [ [ 343, 364 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T33", "type": "Measurement", "text": [ "KPS" ], "offsets": [ [ 428, 431 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T34", "type": "Value", "text": [ "= 70" ], "offsets": [ [ 431, 435 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T35", "type": "Measurement", "text": [ "bone marrow reserve function" ], "offsets": [ [ 443, 471 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T36", "type": "Value", "text": [ "Normal" ], "offsets": [ [ 436, 442 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T37", "type": "Measurement", "text": [ "kidney function" ], "offsets": [ [ 490, 505 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T38", "type": "Measurement", "text": [ ", kid", "ion\nExpe" ], "offsets": [ [ 488, 493 ], [ 502, 510 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T39", "type": "Value", "text": [ "normal" ], "offsets": [ [ 476, 482 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T40", "type": "Observation", "text": [ "Expected survival period" ], "offsets": [ [ 506, 530 ] ], "normalized": [] }, { "id": "NCT03017053_inc_T41", "type": "Value", "text": [ "= 6 month" ], "offsets": [ [ 530, 539 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03017053_inc_R1", "type": "Has_value", "arg1_id": "NCT03017053_inc_T2", "arg2_id": "NCT03017053_inc_T3", "normalized": [] }, { "id": "NCT03017053_inc_R2", "type": "Has_scope", "arg1_id": "NCT03017053_inc_T4", "arg2_id": "NCT03017053_inc_T7", "normalized": [] }, { "id": "NCT03017053_inc_R3", "type": "Subsumes", "arg1_id": "NCT03017053_inc_T7", "arg2_id": "NCT03017053_inc_T13", "normalized": [] }, { "id": "NCT03017053_inc_R4", "type": "Has_value", "arg1_id": "NCT03017053_inc_T14", "arg2_id": "NCT03017053_inc_T15", "normalized": [] }, { "id": "NCT03017053_inc_R5", "type": "AND", "arg1_id": "NCT03017053_inc_T16", "arg2_id": "NCT03017053_inc_T14", "normalized": [] }, { "id": "NCT03017053_inc_R6", "type": "AND", "arg1_id": "NCT03017053_inc_T4", "arg2_id": "NCT03017053_inc_T16", "normalized": [] }, { "id": "NCT03017053_inc_R7", "type": "Has_scope", "arg1_id": "NCT03017053_inc_T4", "arg2_id": "NCT03017053_inc_T21", "normalized": [] }, { "id": "NCT03017053_inc_R8", "type": "Has_value", "arg1_id": "NCT03017053_inc_T25", "arg2_id": "NCT03017053_inc_T26", "normalized": [] }, { "id": "NCT03017053_inc_R9", "type": "Has_value", "arg1_id": "NCT03017053_inc_T27", "arg2_id": "NCT03017053_inc_T28", "normalized": [] }, { "id": "NCT03017053_inc_R10", "type": "Has_value", "arg1_id": "NCT03017053_inc_T29", "arg2_id": "NCT03017053_inc_T30", "normalized": [] }, { "id": "NCT03017053_inc_R11", "type": "Subsumes", "arg1_id": "NCT03017053_inc_T32", "arg2_id": "NCT03017053_inc_T31", "normalized": [] }, { "id": "NCT03017053_inc_R12", "type": "Has_value", "arg1_id": "NCT03017053_inc_T33", "arg2_id": "NCT03017053_inc_T34", "normalized": [] }, { "id": "NCT03017053_inc_R13", "type": "Has_value", "arg1_id": "NCT03017053_inc_T35", "arg2_id": "NCT03017053_inc_T36", "normalized": [] }, { "id": "NCT03017053_inc_R14", "type": "Has_value", "arg1_id": "NCT03017053_inc_T38", "arg2_id": "NCT03017053_inc_T39", "normalized": [] }, { "id": "NCT03017053_inc_R15", "type": "Has_value", "arg1_id": "NCT03017053_inc_T37", "arg2_id": "NCT03017053_inc_T39", "normalized": [] }, { "id": "NCT03017053_inc_R16", "type": "Has_value", "arg1_id": "NCT03017053_inc_T40", "arg2_id": "NCT03017053_inc_T41", "normalized": [] } ]

[ { "id": "NCT03018171_exc_text", "type": "exclusion", "text": [ "Suspect or certainty of fetal malformation,\nPresence of conditions such as preeclampsia, multiparity, preterm labor\nHistory of adverse reaction to a-2 adrenergic agonists\nNicotine addiction\nChronic use of opioid\n" ], "offsets": [ [ 0, 212 ] ] } ]

[ { "id": "NCT03018171_exc_T1", "type": "Condition", "text": [ "fetal malformation" ], "offsets": [ [ 24, 42 ] ], "normalized": [] }, { "id": "NCT03018171_exc_T2", "type": "Mood", "text": [ "certainty" ], "offsets": [ [ 11, 20 ] ], "normalized": [] }, { "id": "NCT03018171_exc_T3", "type": "Mood", "text": [ "Suspect" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "NCT03018171_exc_T4", "type": "Scope", "text": [ "Suspect or certainty" ], "offsets": [ [ 0, 20 ] ], "normalized": [] }, { "id": "NCT03018171_exc_T5", "type": "Condition", "text": [ "preeclampsia" ], "offsets": [ [ 75, 87 ] ], "normalized": [] }, { "id": "NCT03018171_exc_T6", "type": "Condition", "text": [ "multiparity" ], "offsets": [ [ 89, 100 ] ], "normalized": [] }, { "id": "NCT03018171_exc_T7", "type": "Condition", "text": [ "preterm labor" ], "offsets": [ [ 102, 115 ] ], "normalized": [] }, { "id": "NCT03018171_exc_T8", "type": "Condition", "text": [ "adverse reaction" ], "offsets": [ [ 127, 143 ] ], "normalized": [] }, { "id": "NCT03018171_exc_T9", "type": "Drug", "text": [ "a-2 adrenergic agonists" ], "offsets": [ [ 147, 170 ] ], "normalized": [] }, { "id": "NCT03018171_exc_T10", "type": "Condition", "text": [ "Nicotine addiction" ], "offsets": [ [ 171, 189 ] ], "normalized": [] }, { "id": "NCT03018171_exc_T11", "type": "Multiplier", "text": [ "Chronic use" ], "offsets": [ [ 190, 201 ] ], "normalized": [] }, { "id": "NCT03018171_exc_T12", "type": "Drug", "text": [ "opioi" ], "offsets": [ [ 205, 210 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03018171_exc_R1", "type": "Has_scope", "arg1_id": "NCT03018171_exc_T1", "arg2_id": "NCT03018171_exc_T4", "normalized": [] }, { "id": "NCT03018171_exc_R2", "type": "AND", "arg1_id": "NCT03018171_exc_T8", "arg2_id": "NCT03018171_exc_T9", "normalized": [] }, { "id": "NCT03018171_exc_R3", "type": "Has_multiplier", "arg1_id": "NCT03018171_exc_T12", "arg2_id": "NCT03018171_exc_T11", "normalized": [] } ]

[ { "id": "NCT03018171_inc_text", "type": "inclusion", "text": [ "Written maternal informed consent\nSingleton pregnancy\nGestational age = 37 weeks,\nASA I\nBMI < 30\nfetus in cephalic presentation\n" ], "offsets": [ [ 0, 128 ] ] } ]

[ { "id": "NCT03018171_inc_T2", "type": "Condition", "text": [ "Singleton pregnancy" ], "offsets": [ [ 34, 53 ] ], "normalized": [] }, { "id": "NCT03018171_inc_T3", "type": "Measurement", "text": [ "Gestational age" ], "offsets": [ [ 54, 69 ] ], "normalized": [] }, { "id": "NCT03018171_inc_T4", "type": "Value", "text": [ "= 37 weeks" ], "offsets": [ [ 70, 80 ] ], "normalized": [] }, { "id": "NCT03018171_inc_T5", "type": "Measurement", "text": [ "ASA" ], "offsets": [ [ 82, 85 ] ], "normalized": [] }, { "id": "NCT03018171_inc_T6", "type": "Value", "text": [ "I" ], "offsets": [ [ 90, 91 ] ], "normalized": [] }, { "id": "NCT03018171_inc_T7", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 88, 91 ] ], "normalized": [] }, { "id": "NCT03018171_inc_T8", "type": "Value", "text": [ "< 30" ], "offsets": [ [ 92, 96 ] ], "normalized": [] }, { "id": "NCT03018171_inc_T9", "type": "Condition", "text": [ "cephalic presentatio" ], "offsets": [ [ 106, 126 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03018171_inc_R1", "type": "Has_value", "arg1_id": "NCT03018171_inc_T3", "arg2_id": "NCT03018171_inc_T4", "normalized": [] }, { "id": "NCT03018171_inc_R2", "type": "Has_value", "arg1_id": "NCT03018171_inc_T5", "arg2_id": "NCT03018171_inc_T6", "normalized": [] }, { "id": "NCT03018171_inc_R3", "type": "Has_value", "arg1_id": "NCT03018171_inc_T7", "arg2_id": "NCT03018171_inc_T8", "normalized": [] } ]

[ { "id": "NCT03019562_exc_text", "type": "exclusion", "text": [ "Allergic to study drugs\nPatient with asthma or COPD, patient who is severely respiratory depressed\nRenal of hepatic insufficiency\nEpileptic status\nIntracranial lesion associated with increased intracranial pressure\nAcute abdomen, patient who has diagnosed paralytic ileus or suspicious ileus\nPregnant or lactating women\n" ], "offsets": [ [ 0, 320 ] ] } ]

[ { "id": "NCT03019562_exc_T1", "type": "Condition", "text": [ "Allergic" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT03019562_exc_T2", "type": "Drug", "text": [ "study drugs" ], "offsets": [ [ 12, 23 ] ], "normalized": [] }, { "id": "NCT03019562_exc_T3", "type": "Condition", "text": [ "asthma" ], "offsets": [ [ 37, 43 ] ], "normalized": [] }, { "id": "NCT03019562_exc_T4", "type": "Condition", "text": [ "COPD" ], "offsets": [ [ 47, 51 ] ], "normalized": [] }, { "id": "NCT03019562_exc_T5", "type": "Qualifier", "text": [ "severely" ], "offsets": [ [ 68, 76 ] ], "normalized": [] }, { "id": "NCT03019562_exc_T6", "type": "Condition", "text": [ "respiratory depressed" ], "offsets": [ [ 77, 98 ] ], "normalized": [] }, { "id": "NCT03019562_exc_T7", "type": "Condition", "text": [ "hepatic insufficiency" ], "offsets": [ [ 108, 129 ] ], "normalized": [] }, { "id": "NCT03019562_exc_T8", "type": "Condition", "text": [ "nal o", "sufficiency\nE" ], "offsets": [ [ 101, 106 ], [ 118, 131 ] ], "normalized": [] }, { "id": "NCT03019562_exc_T9", "type": "Condition", "text": [ "Epileptic status" ], "offsets": [ [ 130, 146 ] ], "normalized": [] }, { "id": "NCT03019562_exc_T10", "type": "Condition", "text": [ "Intracranial lesion" ], "offsets": [ [ 147, 166 ] ], "normalized": [] }, { "id": "NCT03019562_exc_T11", "type": "Measurement", "text": [ "intracranial pressure" ], "offsets": [ [ 193, 214 ] ], "normalized": [] }, { "id": "NCT03019562_exc_T12", "type": "Value", "text": [ "increased" ], "offsets": [ [ 183, 192 ] ], "normalized": [] }, { "id": "NCT03019562_exc_T13", "type": "Condition", "text": [ "Acute abdomen" ], "offsets": [ [ 215, 228 ] ], "normalized": [] }, { "id": "NCT03019562_exc_T14", "type": "Condition", "text": [ "paralytic ileus" ], "offsets": [ [ 256, 271 ] ], "normalized": [] }, { "id": "NCT03019562_exc_T15", "type": "Condition", "text": [ "suspicious ileus" ], "offsets": [ [ 275, 291 ] ], "normalized": [] }, { "id": "NCT03019562_exc_T16", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 292, 300 ] ], "normalized": [] }, { "id": "NCT03019562_exc_T17", "type": "Condition", "text": [ "lactating" ], "offsets": [ [ 304, 313 ] ], "normalized": [] }, { "id": "NCT03019562_exc_T18", "type": "Person", "text": [ "wome" ], "offsets": [ [ 314, 318 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03019562_exc_R1", "type": "AND", "arg1_id": "NCT03019562_exc_T1", "arg2_id": "NCT03019562_exc_T2", "normalized": [] }, { "id": "NCT03019562_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03019562_exc_T6", "arg2_id": "NCT03019562_exc_T5", "normalized": [] }, { "id": "NCT03019562_exc_R3", "type": "Has_value", "arg1_id": "NCT03019562_exc_T11", "arg2_id": "NCT03019562_exc_T12", "normalized": [] }, { "id": "NCT03019562_exc_R4", "type": "AND", "arg1_id": "NCT03019562_exc_T10", "arg2_id": "NCT03019562_exc_T11", "normalized": [] } ]

[ { "id": "NCT03019562_inc_text", "type": "inclusion", "text": [ "19-65 years of age\nASA physical status classification I or II\nScheduled for total hip replacement surgery\n" ], "offsets": [ [ 0, 106 ] ] } ]

[ { "id": "NCT03019562_inc_T1", "type": "Value", "text": [ "19-65 years" ], "offsets": [ [ 0, 11 ] ], "normalized": [] }, { "id": "NCT03019562_inc_T2", "type": "Person", "text": [ "age" ], "offsets": [ [ 15, 18 ] ], "normalized": [] }, { "id": "NCT03019562_inc_T3", "type": "Measurement", "text": [ "ASA physical status classification" ], "offsets": [ [ 19, 53 ] ], "normalized": [] }, { "id": "NCT03019562_inc_T4", "type": "Value", "text": [ "I or II" ], "offsets": [ [ 54, 61 ] ], "normalized": [] }, { "id": "NCT03019562_inc_T5", "type": "Procedure", "text": [ "total hip replacement surger" ], "offsets": [ [ 76, 104 ] ], "normalized": [] }, { "id": "NCT03019562_inc_T6", "type": "Mood", "text": [ "Scheduled for" ], "offsets": [ [ 62, 75 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03019562_inc_R1", "type": "Has_value", "arg1_id": "NCT03019562_inc_T2", "arg2_id": "NCT03019562_inc_T1", "normalized": [] }, { "id": "NCT03019562_inc_R2", "type": "Has_mood", "arg1_id": "NCT03019562_inc_T5", "arg2_id": "NCT03019562_inc_T6", "normalized": [] } ]

[ { "id": "NCT03025620_exc_text", "type": "exclusion", "text": [ "Patients unable to understand the objectives of the dietary intervention \nPatients in paliative care \nPatients receiving supplement diets \n \n" ], "offsets": [ [ 0, 150 ] ] } ]

[]

[]

[]

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[ { "id": "NCT03025620_inc_text", "type": "inclusion", "text": [ "Elderly patients over 65 years old exhibiting clinical indices of cardiovascular disease \nMale or female \nSubjects who were hospitalized in the Geriatric Unit of the Emile Roux Hospital (AP-HP) \nMMSE (Mini Mental State Examination)score > or = 15 \nSupervision available for study medication \nAble to ingest oral diet \n" ], "offsets": [ [ 0, 318 ] ] } ]

[ { "id": "NCT03025620_inc_T1", "type": "Person", "text": [ "old" ], "offsets": [ [ 31, 34 ] ], "normalized": [] }, { "id": "NCT03025620_inc_T2", "type": "Value", "text": [ "over 65 years" ], "offsets": [ [ 17, 30 ] ], "normalized": [] }, { "id": "NCT03025620_inc_T3", "type": "Person", "text": [ "Elderly" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "NCT03025620_inc_T5", "type": "Person", "text": [ "Male" ], "offsets": [ [ 90, 94 ] ], "normalized": [] }, { "id": "NCT03025620_inc_T6", "type": "Person", "text": [ "female" ], "offsets": [ [ 98, 104 ] ], "normalized": [] }, { "id": "NCT03025620_inc_T7", "type": "Visit", "text": [ "Geriatric Unit of the Emile Roux Hospital (AP-HP)" ], "offsets": [ [ 144, 193 ] ], "normalized": [] }, { "id": "NCT03025620_inc_T8", "type": "Measurement", "text": [ "MMSE (Mini Mental State Examination)" ], "offsets": [ [ 195, 231 ] ], "normalized": [] }, { "id": "NCT03025620_inc_T9", "type": "Value", "text": [ "score > or = 15" ], "offsets": [ [ 231, 246 ] ], "normalized": [] }, { "id": "NCT03025620_inc_T11", "type": "Condition", "text": [ "Able to ingest oral diet" ], "offsets": [ [ 292, 316 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03025620_inc_R1", "type": "Has_value", "arg1_id": "NCT03025620_inc_T1", "arg2_id": "NCT03025620_inc_T2", "normalized": [] }, { "id": "NCT03025620_inc_R2", "type": "Subsumes", "arg1_id": "NCT03025620_inc_T3", "arg2_id": "NCT03025620_inc_T1", "normalized": [] }, { "id": "NCT03025620_inc_R3", "type": "Has_value", "arg1_id": "NCT03025620_inc_T8", "arg2_id": "NCT03025620_inc_T9", "normalized": [] } ]

[ { "id": "NCT03026088_exc_text", "type": "exclusion", "text": [ "Acute coronary syndrome (ACS) within 3 months.\nUnder beta-blocker treatment for the last 2 weeks.\nUnder other medicine treatment which may affect heart rate, like Non-dihydropyridine calcium channel blockers (NDHP-CCBs) or ivabradine for the last 2 weeks; Under Digoxin treatment [more than (>) 0.125 milligram (mg)].\nUncontrolled Diabetes [hemoglobin A1c, (HbA1c) >7.5%].\nSevere or uncontrolled hypertension [resting Systolic Blood Pressure (SBP) >180 millimeters of mercury (mmHg), or resting Diastolic Blood Pressure (DBP) >110mmHg at screening period].\nSevere hypotension [resting SBP less than (<) 90mmHg, or resting DBP<50mmHg].\nResting heart rate <60 beat per minute (bpm).\nAny contradiction to Bisoprolol according to label, including:\nAcute heart failure or during episodes of heart failure decompensation requiring intravenous inotropic therapy.\nCardiogenic shock.\nAtrioventricular block of second or third degree (without a pacemaker).\nSick sinus syndrome.\nSinoatrial block.\nSlowed heart rate, causing symptoms (symptomatic bradycardia),\nDecreased blood pressure, causing symptoms (symptomatic hypotension),\nSevere bronchial asthma or severe chronic obstructive pulmonary disease.\nSever forms of peripheral arterial occlusive disease and Raynaud's syndrome.\nUntreated phaeochromocytoma.\nMetabolic acidosis.\nHypersensitivity to bisoprolol or to any of the excipients.\nSevere Arrhythmia including atrial fibrillation, atrial flutter, ventricular fibrillation, ventricular flutter or ventricular tachycardia.\nSignificant valvular heart disease, congenital heart disease, pulmonary heart disease or perinatal heart disease.\nAcute pulmonary edema.\nSevere hepatic dysfunction, defined as:\nSerum Alanine Aminotransferase (ALT) > triple the upper limit of the normal range; and/or\nSerum Aspartate Aminotransferase (AST) > triple the upper limit of the normal value range and/or\nSevere renal dysfunction, defined as:\nSerum creatinine > twice the upper limit of the normal range\nChronic Kidney Disease (glomerular filtration rate <45 Milliliter per minute).\nHyperthyroidism or hypothyroidism.\nSevere infectious disease, example (eg) Human Immunodeficiency Virus positive or active tuberculosis.\nSevere autoimmune disease, e.g. lupus erythematosus, multiple sclerosis.\nSevere respiratory, digestive, hematological disease (including Anemia of Hb < 100 gram per litre) or tumor.\nKnown to be hypersensitivity to Bisoprolol, or any of the excipient.\nSubstance or alcohol abuse.\nReceived heart transplantation or pacemaker implantation; revascularization treatment within 3 months; or plan to receive above treatment in 6 months.\nCurrently undertaking other treatment that may affect the safety and/or efficacy evaluation, e.g. beta receptors agonists, et cetera.\nNo legal ability or legal ability is limited.\nSubjects unlikely to cooperate in the study or with inability or unwillingness to give informed consent.\nChild-bearing period women without effective contraceptive measures, pregnancy and lactation.\nParticipation in another clinical trial within the past 90 days.\nOther significant condition that in the Investigator's opinion would exclude the subject from the trial.\n" ], "offsets": [ [ 0, 3175 ] ] } ]

[ { "id": "NCT03026088_exc_T1", "type": "Condition", "text": [ "Acute coronary syndrome" ], "offsets": [ [ 0, 23 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T2", "type": "Condition", "text": [ "ACS" ], "offsets": [ [ 25, 28 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T3", "type": "Temporal", "text": [ "within 3 months" ], "offsets": [ [ 30, 45 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T4", "type": "Drug", "text": [ "beta-blocker" ], "offsets": [ [ 53, 65 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T5", "type": "Temporal", "text": [ "for the last 2 weeks" ], "offsets": [ [ 76, 96 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T6", "type": "Drug", "text": [ "Non-dihydropyridine calcium channel blockers" ], "offsets": [ [ 163, 207 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T7", "type": "Drug", "text": [ "NDHP-CCBs" ], "offsets": [ [ 209, 218 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T8", "type": "Drug", "text": [ "ivabradine" ], "offsets": [ [ 223, 233 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T9", "type": "Temporal", "text": [ "for the last 2 weeks" ], "offsets": [ [ 234, 254 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T10", "type": "Drug", "text": [ "Digoxin" ], "offsets": [ [ 262, 269 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T11", "type": "Multiplier", "text": [ "re than (", "125 milligram (" ], "offsets": [ [ 283, 292 ], [ 297, 312 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T12", "type": "Value", "text": [ "", "125 m", ")]" ], "offsets": [ [ 294, 294 ], [ 297, 302 ], [ 314, 316 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T13", "type": "Scope", "text": [ "Non-dihydropyridine calcium channel blockers (NDHP-CCBs) or ivabradine" ], "offsets": [ [ 163, 233 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T15", "type": "Condition", "text": [ "Diabetes" ], "offsets": [ [ 331, 339 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T16", "type": "Qualifier", "text": [ "Uncontrolled" ], "offsets": [ [ 318, 330 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T17", "type": "Measurement", "text": [ "hemoglobin A1c" ], "offsets": [ [ 341, 355 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T18", "type": "Measurement", "text": [ "HbA1c" ], "offsets": [ [ 358, 363 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T19", "type": "Value", "text": [ ">7.5%" ], "offsets": [ [ 365, 370 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T20", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 396, 408 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T21", "type": "Qualifier", "text": [ "uncontrolled" ], "offsets": [ [ 383, 395 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T22", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 373, 379 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T23", "type": "Scope", "text": [ "Severe or uncontrolled" ], "offsets": [ [ 373, 395 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T24", "type": "Measurement", "text": [ "Systolic Blood Pressure" ], "offsets": [ [ 418, 441 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T25", "type": "Measurement", "text": [ "SBP" ], "offsets": [ [ 443, 446 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T26", "type": "Value", "text": [ ">180 millimeters of mercury" ], "offsets": [ [ 448, 475 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T27", "type": "Value", "text": [ " mi", "), o" ], "offsets": [ [ 452, 455 ], [ 481, 485 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T28", "type": "Measurement", "text": [ "Diastolic Blood Pressure" ], "offsets": [ [ 495, 519 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T29", "type": "Measurement", "text": [ "DBP" ], "offsets": [ [ 521, 524 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T30", "type": "Value", "text": [ ">110mmHg" ], "offsets": [ [ 526, 534 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T31", "type": "Temporal", "text": [ "at screening period" ], "offsets": [ [ 535, 554 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T32", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 538, 547 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T33", "type": "Qualifier", "text": [ "resting" ], "offsets": [ [ 487, 494 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T34", "type": "Qualifier", "text": [ "resting" ], "offsets": [ [ 410, 417 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T35", "type": "Scope", "text": [ "resting Systolic Blood Pressure (SBP) >180 millimeters of mercury (mmHg), or resting Diastolic Blood Pressure (DBP) >110mmHg at screening period" ], "offsets": [ [ 410, 554 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T36", "type": "Scope", "text": [ "resting Systolic Blood Pressure (SBP) >180 millimeters of mercury (mmHg), or resting Diastolic Blood Pressure (DBP) >110mmHg" ], "offsets": [ [ 410, 534 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T37", "type": "Condition", "text": [ "hypotension" ], "offsets": [ [ 564, 575 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T38", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 557, 563 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T39", "type": "Measurement", "text": [ "SBP" ], "offsets": [ [ 585, 588 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T40", "type": "Value", "text": [ "than (<)", "g, or" ], "offsets": [ [ 594, 602 ], [ 608, 613 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T41", "type": "Qualifier", "text": [ "resting" ], "offsets": [ [ 577, 584 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T42", "type": "Qualifier", "text": [ "resting" ], "offsets": [ [ 614, 621 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T43", "type": "Measurement", "text": [ "DBP" ], "offsets": [ [ 622, 625 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T44", "type": "Value", "text": [ "<50mmHg" ], "offsets": [ [ 625, 632 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T45", "type": "Scope", "text": [ "resting SBP less than (<) 90mmHg, or resting DBP<50mmHg" ], "offsets": [ [ 577, 632 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T46", "type": "Measurement", "text": [ "heart rate" ], "offsets": [ [ 643, 653 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T47", "type": "Qualifier", "text": [ "Resting" ], "offsets": [ [ 635, 642 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T48", "type": "Value", "text": [ "<60 beat per minute" ], "offsets": [ [ 654, 673 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T49", "type": "Value", "text": [ "at", "Any" ], "offsets": [ [ 660, 662 ], [ 681, 684 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T50", "type": "Drug", "text": [ "Bisoprolol" ], "offsets": [ [ 702, 712 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T51", "type": "Condition", "text": [ "contradiction" ], "offsets": [ [ 685, 698 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T52", "type": "Condition", "text": [ "Acute heart failure" ], "offsets": [ [ 744, 763 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T53", "type": "Condition", "text": [ "heart failure decompensation" ], "offsets": [ [ 786, 814 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T54", "type": "Procedure", "text": [ "intravenous inotropic therapy" ], "offsets": [ [ 825, 854 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T55", "type": "Condition", "text": [ "Cardiogenic shock" ], "offsets": [ [ 856, 873 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T56", "type": "Condition", "text": [ "icular block of second or third", "thout" ], "offsets": [ [ 885, 916 ], [ 927, 932 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T57", "type": "Condition", "text": [ "icular block of second or", "ee (without" ], "offsets": [ [ 885, 910 ], [ 921, 932 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T58", "type": "Device", "text": [ "pacemaker" ], "offsets": [ [ 935, 944 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T59", "type": "Negation", "text": [ "without" ], "offsets": [ [ 925, 932 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T60", "type": "Condition", "text": [ "Sick sinus syndrome" ], "offsets": [ [ 947, 966 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T61", "type": "Condition", "text": [ "Sinoatrial block" ], "offsets": [ [ 968, 984 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T62", "type": "Condition", "text": [ "heart rate" ], "offsets": [ [ 993, 1003 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T63", "type": "Qualifier", "text": [ "Slowed" ], "offsets": [ [ 986, 992 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T64", "type": "Condition", "text": [ "bradycardia" ], "offsets": [ [ 1035, 1046 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T65", "type": "Qualifier", "text": [ "symptomatic" ], "offsets": [ [ 1023, 1034 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T66", "type": "Condition", "text": [ "symptoms" ], "offsets": [ [ 1013, 1021 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T67", "type": "Condition", "text": [ "blood pressure" ], "offsets": [ [ 1059, 1073 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T68", "type": "Qualifier", "text": [ "Decreased" ], "offsets": [ [ 1049, 1058 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T69", "type": "Condition", "text": [ "symptoms" ], "offsets": [ [ 1083, 1091 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T70", "type": "Condition", "text": [ "hypotension" ], "offsets": [ [ 1105, 1116 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T71", "type": "Qualifier", "text": [ "symptomatic" ], "offsets": [ [ 1093, 1104 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T72", "type": "Condition", "text": [ "bronchial asthma" ], "offsets": [ [ 1126, 1142 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T73", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 1119, 1125 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T74", "type": "Condition", "text": [ "chronic obstructive pulmonary disease" ], "offsets": [ [ 1153, 1190 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T75", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 1146, 1152 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T76", "type": "Condition", "text": [ "peripheral arterial occlusive disease" ], "offsets": [ [ 1207, 1244 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T77", "type": "Condition", "text": [ "Raynaud's syndrome" ], "offsets": [ [ 1249, 1267 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T78", "type": "Qualifier", "text": [ "Sever" ], "offsets": [ [ 1192, 1197 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T79", "type": "Scope", "text": [ "peripheral arterial occlusive disease and Raynaud's syndrome" ], "offsets": [ [ 1207, 1267 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T81", "type": "Condition", "text": [ "phaeochromocytoma" ], "offsets": [ [ 1279, 1296 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T82", "type": "Qualifier", "text": [ "Untreated" ], "offsets": [ [ 1269, 1278 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T83", "type": "Condition", "text": [ "Metabolic acidosis" ], "offsets": [ [ 1298, 1316 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T84", "type": "Condition", "text": [ "Hypersensitivity" ], "offsets": [ [ 1318, 1334 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T85", "type": "Drug", "text": [ "bisoprolol" ], "offsets": [ [ 1338, 1348 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T86", "type": "Drug", "text": [ "excipients" ], "offsets": [ [ 1366, 1376 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T87", "type": "Qualifier", "text": [ "any" ], "offsets": [ [ 1355, 1358 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T88", "type": "Scope", "text": [ "bisoprolol or to any of the excipients" ], "offsets": [ [ 1338, 1376 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T89", "type": "Condition", "text": [ "Arrhythmia" ], "offsets": [ [ 1385, 1395 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T90", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 1378, 1384 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T91", "type": "Condition", "text": [ "atrial fibrillation" ], "offsets": [ [ 1406, 1425 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T92", "type": "Condition", "text": [ "atrial flutter" ], "offsets": [ [ 1427, 1441 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T93", "type": "Condition", "text": [ "ventricular fibrillation" ], "offsets": [ [ 1443, 1467 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T94", "type": "Condition", "text": [ "ventricular flutter" ], "offsets": [ [ 1469, 1488 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T95", "type": "Condition", "text": [ "ventricular tachycardia" ], "offsets": [ [ 1492, 1515 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T96", "type": "Scope", "text": [ "atrial fibrillation, atrial flutter, ventricular fibrillation, ventricular flutter or ventricular tachycardia" ], "offsets": [ [ 1406, 1515 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T97", "type": "Condition", "text": [ "valvular heart disease" ], "offsets": [ [ 1529, 1551 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T98", "type": "Qualifier", "text": [ "Significant" ], "offsets": [ [ 1517, 1528 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T99", "type": "Condition", "text": [ "congenital heart disease" ], "offsets": [ [ 1553, 1577 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T100", "type": "Condition", "text": [ "pulmonary heart disease" ], "offsets": [ [ 1579, 1602 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T101", "type": "Condition", "text": [ "perinatal heart disease" ], "offsets": [ [ 1606, 1629 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T102", "type": "Scope", "text": [ "valvular heart disease, congenital heart disease, pulmonary heart disease or perinatal heart disease" ], "offsets": [ [ 1529, 1629 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T103", "type": "Condition", "text": [ "Acute pulmonary edema" ], "offsets": [ [ 1631, 1652 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T104", "type": "Condition", "text": [ "hepatic dysfunction" ], "offsets": [ [ 1661, 1680 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T105", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 1654, 1660 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T106", "type": "Measurement", "text": [ "Serum Alanine Aminotransferase" ], "offsets": [ [ 1694, 1724 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T107", "type": "Measurement", "text": [ "ALT" ], "offsets": [ [ 1726, 1729 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T108", "type": "Value", "text": [ "> triple the upper limit of the normal range" ], "offsets": [ [ 1731, 1775 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T110", "type": "Measurement", "text": [ "Serum Aspartate Aminotransferase" ], "offsets": [ [ 1784, 1816 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T111", "type": "Measurement", "text": [ "AST" ], "offsets": [ [ 1818, 1821 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T112", "type": "Value", "text": [ "> triple the upper limit of the normal value range" ], "offsets": [ [ 1823, 1873 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T114", "type": "Condition", "text": [ "renal dysfunction" ], "offsets": [ [ 1888, 1905 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T115", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 1881, 1887 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T116", "type": "Measurement", "text": [ "Serum creatinine" ], "offsets": [ [ 1919, 1935 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T117", "type": "Value", "text": [ "> twice the upper limit of the normal range" ], "offsets": [ [ 1936, 1979 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T118", "type": "Condition", "text": [ "Chronic Kidney Disease" ], "offsets": [ [ 1980, 2002 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T119", "type": "Measurement", "text": [ "glomerular filtration rate" ], "offsets": [ [ 2004, 2030 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T120", "type": "Value", "text": [ "<45 Milliliter per minute" ], "offsets": [ [ 2031, 2056 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T121", "type": "Condition", "text": [ "Hyperthyroidism" ], "offsets": [ [ 2059, 2074 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T122", "type": "Condition", "text": [ "hypothyroidism" ], "offsets": [ [ 2078, 2092 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T123", "type": "Condition", "text": [ "infectious disease" ], "offsets": [ [ 2101, 2119 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T124", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 2094, 2100 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T125", "type": "Condition", "text": [ "Human Immunodeficiency Virus positive" ], "offsets": [ [ 2134, 2171 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T127", "type": "Condition", "text": [ "tuberculosis" ], "offsets": [ [ 2182, 2194 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T128", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 2175, 2181 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T126", "type": "Scope", "text": [ "Human Immunodeficiency Virus positive or active tuberculosis" ], "offsets": [ [ 2134, 2194 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T129", "type": "Condition", "text": [ "autoimmune disease" ], "offsets": [ [ 2203, 2221 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T130", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 2196, 2202 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T131", "type": "Condition", "text": [ "lupus erythematosus" ], "offsets": [ [ 2228, 2247 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T132", "type": "Condition", "text": [ "multiple sclerosis" ], "offsets": [ [ 2249, 2267 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T133", "type": "Scope", "text": [ "lupus erythematosus, multiple sclerosis" ], "offsets": [ [ 2228, 2267 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T134", "type": "Condition", "text": [ "gical disea", "< 100 g" ], "offsets": [ [ 2308, 2319 ], [ 2346, 2353 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T135", "type": "Condition", "text": [ " (includ", "< 100 g" ], "offsets": [ [ 2321, 2329 ], [ 2346, 2353 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T136", "type": "Condition", "text": [ "hematological disease" ], "offsets": [ [ 2300, 2321 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T137", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 2269, 2275 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T138", "type": "Scope", "text": [ "respiratory, digestive, hematological disease" ], "offsets": [ [ 2276, 2321 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T139", "type": "Condition", "text": [ "Anemia" ], "offsets": [ [ 2333, 2339 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T140", "type": "Measurement", "text": [ "Hb" ], "offsets": [ [ 2343, 2345 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T141", "type": "Value", "text": [ "< 100 gram per litre" ], "offsets": [ [ 2346, 2366 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T142", "type": "Condition", "text": [ "tumor" ], "offsets": [ [ 2371, 2376 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T143", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 2390, 2406 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T144", "type": "Drug", "text": [ "Bisoprolol" ], "offsets": [ [ 2410, 2420 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T145", "type": "Drug", "text": [ "excipient" ], "offsets": [ [ 2436, 2445 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T146", "type": "Qualifier", "text": [ "any" ], "offsets": [ [ 2425, 2428 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T147", "type": "Scope", "text": [ "Bisoprolol, or any of the excipient" ], "offsets": [ [ 2410, 2445 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T148", "type": "Condition", "text": [ "alcohol abuse" ], "offsets": [ [ 2460, 2473 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T149", "type": "Condition", "text": [ "ed heart", "ion o" ], "offsets": [ [ 2481, 2489 ], [ 2502, 2507 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T150", "type": "Procedure", "text": [ "heart transplantation" ], "offsets": [ [ 2484, 2505 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T151", "type": "Procedure", "text": [ "pacemaker implantation" ], "offsets": [ [ 2509, 2531 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T152", "type": "Procedure", "text": [ "revascularization" ], "offsets": [ [ 2533, 2550 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T153", "type": "Temporal", "text": [ "within 3 months" ], "offsets": [ [ 2561, 2576 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T154", "type": "Mood", "text": [ "plan to" ], "offsets": [ [ 2581, 2588 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T155", "type": "Temporal", "text": [ "in 6 months" ], "offsets": [ [ 2613, 2624 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T156", "type": "Scope", "text": [ "heart transplantation or pacemaker implantation; revascularization" ], "offsets": [ [ 2484, 2550 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T157", "type": "Procedure", "text": [ "heart transplantation" ], "offsets": [ [ 2484, 2505 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T158", "type": "Procedure", "text": [ "pacemaker implantation" ], "offsets": [ [ 2509, 2531 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T159", "type": "Procedure", "text": [ "revascularization" ], "offsets": [ [ 2533, 2550 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T160", "type": "Scope", "text": [ "heart transplantation or pacemaker implantation; revascularization" ], "offsets": [ [ 2484, 2550 ] ], "normalized": [] }, { "id": "NCT03026088_exc_T162", "type": "Drug", "text": [ "beta receptors agonists" ], "offsets": [ [ 2724, 2747 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03026088_exc_R1", "type": "Subsumes", "arg1_id": "NCT03026088_exc_T1", "arg2_id": "NCT03026088_exc_T2", "normalized": [] }, { "id": "NCT03026088_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03026088_exc_T1", "arg2_id": "NCT03026088_exc_T3", "normalized": [] }, { "id": "NCT03026088_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03026088_exc_T4", "arg2_id": "NCT03026088_exc_T5", "normalized": [] }, { "id": "NCT03026088_exc_R4", "type": "Subsumes", "arg1_id": "NCT03026088_exc_T6", "arg2_id": "NCT03026088_exc_T7", "normalized": [] }, { "id": "NCT03026088_exc_R5", "type": "Subsumes", "arg1_id": "NCT03026088_exc_T11", "arg2_id": "NCT03026088_exc_T12", "normalized": [] }, { "id": "NCT03026088_exc_R6", "type": "Has_multiplier", "arg1_id": "NCT03026088_exc_T10", "arg2_id": "NCT03026088_exc_T11", "normalized": [] }, { "id": "NCT03026088_exc_R7", "type": "Has_temporal", "arg1_id": "NCT03026088_exc_T13", "arg2_id": "NCT03026088_exc_T9", "normalized": [] }, { "id": "NCT03026088_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T15", "arg2_id": "NCT03026088_exc_T16", "normalized": [] }, { "id": "NCT03026088_exc_R9", "type": "Subsumes", "arg1_id": "NCT03026088_exc_T17", "arg2_id": "NCT03026088_exc_T18", "normalized": [] }, { "id": "NCT03026088_exc_R10", "type": "Has_value", "arg1_id": "NCT03026088_exc_T17", "arg2_id": "NCT03026088_exc_T19", "normalized": [] }, { "id": "NCT03026088_exc_R11", "type": "AND", "arg1_id": "NCT03026088_exc_T15", "arg2_id": "NCT03026088_exc_T17", "normalized": [] }, { "id": "NCT03026088_exc_R12", "type": "Has_scope", "arg1_id": "NCT03026088_exc_T20", "arg2_id": "NCT03026088_exc_T23", "normalized": [] }, { "id": "NCT03026088_exc_R13", "type": "Subsumes", "arg1_id": "NCT03026088_exc_T26", "arg2_id": "NCT03026088_exc_T27", "normalized": [] }, { "id": "NCT03026088_exc_R14", "type": "Has_index", "arg1_id": "NCT03026088_exc_T31", "arg2_id": "NCT03026088_exc_T32", "normalized": [] }, { "id": "NCT03026088_exc_R15", "type": "Subsumes", "arg1_id": "NCT03026088_exc_T28", "arg2_id": "NCT03026088_exc_T29", "normalized": [] }, { "id": "NCT03026088_exc_R16", "type": "Has_value", "arg1_id": "NCT03026088_exc_T28", "arg2_id": "NCT03026088_exc_T30", "normalized": [] }, { "id": "NCT03026088_exc_R17", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T28", "arg2_id": "NCT03026088_exc_T33", "normalized": [] }, { "id": "NCT03026088_exc_R18", "type": "Subsumes", "arg1_id": "NCT03026088_exc_T24", "arg2_id": "NCT03026088_exc_T25", "normalized": [] }, { "id": "NCT03026088_exc_R19", "type": "Has_value", "arg1_id": "NCT03026088_exc_T24", "arg2_id": "NCT03026088_exc_T26", "normalized": [] }, { "id": "NCT03026088_exc_R20", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T24", "arg2_id": "NCT03026088_exc_T34", "normalized": [] }, { "id": "NCT03026088_exc_R21", "type": "Has_scope", "arg1_id": "NCT03026088_exc_T20", "arg2_id": "NCT03026088_exc_T35", "normalized": [] }, { "id": "NCT03026088_exc_R22", "type": "Has_temporal", "arg1_id": "NCT03026088_exc_T36", "arg2_id": "NCT03026088_exc_T31", "normalized": [] }, { "id": "NCT03026088_exc_R23", "type": "Has_value", "arg1_id": "NCT03026088_exc_T43", "arg2_id": "NCT03026088_exc_T44", "normalized": [] }, { "id": "NCT03026088_exc_R24", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T43", "arg2_id": "NCT03026088_exc_T42", "normalized": [] }, { "id": "NCT03026088_exc_R25", "type": "Has_value", "arg1_id": "NCT03026088_exc_T39", "arg2_id": "NCT03026088_exc_T40", "normalized": [] }, { "id": "NCT03026088_exc_R26", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T39", "arg2_id": "NCT03026088_exc_T41", "normalized": [] }, { "id": "NCT03026088_exc_R27", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T37", "arg2_id": "NCT03026088_exc_T38", "normalized": [] }, { "id": "NCT03026088_exc_R28", "type": "Has_scope", "arg1_id": "NCT03026088_exc_T37", "arg2_id": "NCT03026088_exc_T45", "normalized": [] }, { "id": "NCT03026088_exc_R29", "type": "Subsumes", "arg1_id": "NCT03026088_exc_T48", "arg2_id": "NCT03026088_exc_T49", "normalized": [] }, { "id": "NCT03026088_exc_R30", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T46", "arg2_id": "NCT03026088_exc_T47", "normalized": [] }, { "id": "NCT03026088_exc_R31", "type": "Has_value", "arg1_id": "NCT03026088_exc_T46", "arg2_id": "NCT03026088_exc_T48", "normalized": [] }, { "id": "NCT03026088_exc_R32", "type": "AND", "arg1_id": "NCT03026088_exc_T51", "arg2_id": "NCT03026088_exc_T50", "normalized": [] }, { "id": "NCT03026088_exc_R33", "type": "AND", "arg1_id": "NCT03026088_exc_T53", "arg2_id": "NCT03026088_exc_T54", "normalized": [] }, { "id": "NCT03026088_exc_R34", "type": "Has_negation", "arg1_id": "NCT03026088_exc_T58", "arg2_id": "NCT03026088_exc_T59", "normalized": [] }, { "id": "NCT03026088_exc_R35", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T62", "arg2_id": "NCT03026088_exc_T63", "normalized": [] }, { "id": "NCT03026088_exc_R36", "type": "AND", "arg1_id": "NCT03026088_exc_T62", "arg2_id": "NCT03026088_exc_T66", "normalized": [] }, { "id": "NCT03026088_exc_R37", "type": "Subsumes", "arg1_id": "NCT03026088_exc_T62", "arg2_id": "NCT03026088_exc_T64", "normalized": [] }, { "id": "NCT03026088_exc_R38", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T64", "arg2_id": "NCT03026088_exc_T65", "normalized": [] }, { "id": "NCT03026088_exc_R39", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T67", "arg2_id": "NCT03026088_exc_T68", "normalized": [] }, { "id": "NCT03026088_exc_R40", "type": "AND", "arg1_id": "NCT03026088_exc_T67", "arg2_id": "NCT03026088_exc_T69", "normalized": [] }, { "id": "NCT03026088_exc_R41", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T70", "arg2_id": "NCT03026088_exc_T71", "normalized": [] }, { "id": "NCT03026088_exc_R42", "type": "Subsumes", "arg1_id": "NCT03026088_exc_T67", "arg2_id": "NCT03026088_exc_T70", "normalized": [] }, { "id": "NCT03026088_exc_R43", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T74", "arg2_id": "NCT03026088_exc_T75", "normalized": [] }, { "id": "NCT03026088_exc_R44", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T72", "arg2_id": "NCT03026088_exc_T73", "normalized": [] }, { "id": "NCT03026088_exc_R45", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T79", "arg2_id": "NCT03026088_exc_T78", "normalized": [] }, { "id": "NCT03026088_exc_R46", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T81", "arg2_id": "NCT03026088_exc_T82", "normalized": [] }, { "id": "NCT03026088_exc_R47", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T86", "arg2_id": "NCT03026088_exc_T87", "normalized": [] }, { "id": "NCT03026088_exc_R48", "type": "Has_scope", "arg1_id": "NCT03026088_exc_T84", "arg2_id": "NCT03026088_exc_T88", "normalized": [] }, { "id": "NCT03026088_exc_R49", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T89", "arg2_id": "NCT03026088_exc_T90", "normalized": [] }, { "id": "NCT03026088_exc_R50", "type": "Subsumes", "arg1_id": "NCT03026088_exc_T89", "arg2_id": "NCT03026088_exc_T96", "normalized": [] }, { "id": "NCT03026088_exc_R51", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T102", "arg2_id": "NCT03026088_exc_T98", "normalized": [] }, { "id": "NCT03026088_exc_R52", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T104", "arg2_id": "NCT03026088_exc_T105", "normalized": [] }, { "id": "NCT03026088_exc_R53", "type": "Subsumes", "arg1_id": "NCT03026088_exc_T106", "arg2_id": "NCT03026088_exc_T107", "normalized": [] }, { "id": "NCT03026088_exc_R54", "type": "Has_value", "arg1_id": "NCT03026088_exc_T106", "arg2_id": "NCT03026088_exc_T108", "normalized": [] }, { "id": "NCT03026088_exc_R55", "type": "Subsumes", "arg1_id": "NCT03026088_exc_T110", "arg2_id": "NCT03026088_exc_T111", "normalized": [] }, { "id": "NCT03026088_exc_R56", "type": "Has_value", "arg1_id": "NCT03026088_exc_T110", "arg2_id": "NCT03026088_exc_T112", "normalized": [] }, { "id": "NCT03026088_exc_R57", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T114", "arg2_id": "NCT03026088_exc_T115", "normalized": [] }, { "id": "NCT03026088_exc_R58", "type": "Has_value", "arg1_id": "NCT03026088_exc_T116", "arg2_id": "NCT03026088_exc_T117", "normalized": [] }, { "id": "NCT03026088_exc_R59", "type": "Has_value", "arg1_id": "NCT03026088_exc_T119", "arg2_id": "NCT03026088_exc_T120", "normalized": [] }, { "id": "NCT03026088_exc_R60", "type": "AND", "arg1_id": "NCT03026088_exc_T118", "arg2_id": "NCT03026088_exc_T119", "normalized": [] }, { "id": "NCT03026088_exc_R61", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T123", "arg2_id": "NCT03026088_exc_T124", "normalized": [] }, { "id": "NCT03026088_exc_R63", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T127", "arg2_id": "NCT03026088_exc_T128", "normalized": [] }, { "id": "NCT03026088_exc_R62", "type": "Subsumes", "arg1_id": "NCT03026088_exc_T123", "arg2_id": "NCT03026088_exc_T126", "normalized": [] }, { "id": "NCT03026088_exc_R64", "type": "Subsumes", "arg1_id": "NCT03026088_exc_T129", "arg2_id": "NCT03026088_exc_T133", "normalized": [] }, { "id": "NCT03026088_exc_R65", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T129", "arg2_id": "NCT03026088_exc_T130", "normalized": [] }, { "id": "NCT03026088_exc_R66", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T138", "arg2_id": "NCT03026088_exc_T137", "normalized": [] }, { "id": "NCT03026088_exc_R67", "type": "Has_value", "arg1_id": "NCT03026088_exc_T140", "arg2_id": "NCT03026088_exc_T141", "normalized": [] }, { "id": "NCT03026088_exc_R68", "type": "AND", "arg1_id": "NCT03026088_exc_T139", "arg2_id": "NCT03026088_exc_T140", "normalized": [] }, { "id": "NCT03026088_exc_R69", "type": "Subsumes", "arg1_id": "NCT03026088_exc_T138", "arg2_id": "NCT03026088_exc_T139", "normalized": [] }, { "id": "NCT03026088_exc_R70", "type": "Has_qualifier", "arg1_id": "NCT03026088_exc_T145", "arg2_id": "NCT03026088_exc_T146", "normalized": [] }, { "id": "NCT03026088_exc_R71", "type": "Has_scope", "arg1_id": "NCT03026088_exc_T143", "arg2_id": "NCT03026088_exc_T147", "normalized": [] }, { "id": "NCT03026088_exc_R72", "type": "Has_temporal", "arg1_id": "NCT03026088_exc_T156", "arg2_id": "NCT03026088_exc_T153", "normalized": [] }, { "id": "NCT03026088_exc_R73", "type": "Has_mood", "arg1_id": "NCT03026088_exc_T160", "arg2_id": "NCT03026088_exc_T154", "normalized": [] }, { "id": "NCT03026088_exc_R74", "type": "Has_temporal", "arg1_id": "NCT03026088_exc_T160", "arg2_id": "NCT03026088_exc_T155", "normalized": [] } ]

[ { "id": "NCT03026088_inc_text", "type": "inclusion", "text": [ "18-80 year, male or female.\nChronic Heart failure subjects with medical history of cardiac disease or other related cardiovascular disease.\nLeft ventricular ejection fraction (LVEF) less than or equal to (=<) 40 percent (%).\nNew York Heart Association (NYHA) class of II - IV\nNYHA II : Slight limitation of physical activity. Comfortable at rest, but ordinary physical activity results in undue breathlessness, fatigue or palpitation.\nNYHA III:Marked limitation of physical activity. Comfortable at rest, but less than ordinary activity causes undue breathlessness, fatigue or palpitation.\nNYHA IV:Unable to carry on any physical activity without discomfort. Symptoms at rest can be present. If any physical activity is undertaken, discomfort increased.\nSigned Informed Consent Form (ICF).\n" ], "offsets": [ [ 0, 790 ] ] } ]

[ { "id": "NCT03026088_inc_T1", "type": "Person", "text": [ "year" ], "offsets": [ [ 6, 10 ] ], "normalized": [] }, { "id": "NCT03026088_inc_T2", "type": "Value", "text": [ "18-80" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT03026088_inc_T3", "type": "Person", "text": [ "male" ], "offsets": [ [ 12, 16 ] ], "normalized": [] }, { "id": "NCT03026088_inc_T4", "type": "Person", "text": [ "female" ], "offsets": [ [ 20, 26 ] ], "normalized": [] }, { "id": "NCT03026088_inc_T5", "type": "Condition", "text": [ "Chronic Heart failure" ], "offsets": [ [ 28, 49 ] ], "normalized": [] }, { "id": "NCT03026088_inc_T6", "type": "Condition", "text": [ "cardiac disease" ], "offsets": [ [ 83, 98 ] ], "normalized": [] }, { "id": "NCT03026088_inc_T7", "type": "Condition", "text": [ "cardiovascular disease" ], "offsets": [ [ 116, 138 ] ], "normalized": [] }, { "id": "NCT03026088_inc_T8", "type": "Qualifier", "text": [ "related" ], "offsets": [ [ 108, 115 ] ], "normalized": [] }, { "id": "NCT03026088_inc_T9", "type": "Scope", "text": [ "cardiac disease or other related cardiovascular disease" ], "offsets": [ [ 83, 138 ] ], "normalized": [] }, { "id": "NCT03026088_inc_T10", "type": "Measurement", "text": [ "Left ventricular ejection fraction" ], "offsets": [ [ 140, 174 ] ], "normalized": [] }, { "id": "NCT03026088_inc_T11", "type": "Measurement", "text": [ "LVEF" ], "offsets": [ [ 176, 180 ] ], "normalized": [] }, { "id": "NCT03026088_inc_T12", "type": "Value", "text": [ "ss than or equal to (", " percent " ], "offsets": [ [ 184, 205 ], [ 211, 220 ] ], "normalized": [] }, { "id": "NCT03026088_inc_T13", "type": "Value", "text": [ ")", " ", "." ], "offsets": [ [ 207, 208 ], [ 211, 212 ], [ 223, 224 ] ], "normalized": [] }, { "id": "NCT03026088_inc_T14", "type": "Measurement", "text": [ " York Heart Association (", "ss of" ], "offsets": [ [ 228, 253 ], [ 262, 267 ] ], "normalized": [] }, { "id": "NCT03026088_inc_T15", "type": "Value", "text": [ "II - IV" ], "offsets": [ [ 268, 275 ] ], "normalized": [] }, { "id": "NCT03026088_inc_T16", "type": "Measurement", "text": [ "NYHA" ], "offsets": [ [ 253, 257 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03026088_inc_R1", "type": "Has_value", "arg1_id": "NCT03026088_inc_T1", "arg2_id": "NCT03026088_inc_T2", "normalized": [] }, { "id": "NCT03026088_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03026088_inc_T7", "arg2_id": "NCT03026088_inc_T8", "normalized": [] }, { "id": "NCT03026088_inc_R3", "type": "Has_scope", "arg1_id": "NCT03026088_inc_T5", "arg2_id": "NCT03026088_inc_T9", "normalized": [] }, { "id": "NCT03026088_inc_R4", "type": "Has_value", "arg1_id": "NCT03026088_inc_T12", "arg2_id": "NCT03026088_inc_T13", "normalized": [] }, { "id": "NCT03026088_inc_R5", "type": "Subsumes", "arg1_id": "NCT03026088_inc_T10", "arg2_id": "NCT03026088_inc_T11", "normalized": [] }, { "id": "NCT03026088_inc_R6", "type": "Has_value", "arg1_id": "NCT03026088_inc_T10", "arg2_id": "NCT03026088_inc_T12", "normalized": [] }, { "id": "NCT03026088_inc_R7", "type": "Subsumes", "arg1_id": "NCT03026088_inc_T14", "arg2_id": "NCT03026088_inc_T16", "normalized": [] }, { "id": "NCT03026088_inc_R8", "type": "Has_value", "arg1_id": "NCT03026088_inc_T14", "arg2_id": "NCT03026088_inc_T15", "normalized": [] } ]

[ { "id": "NCT03026465_exc_text", "type": "exclusion", "text": [ "Target lesion located in the left main stem\nSTEMI\nRestenosis\nCardiogenic shock\nMalignancies or other comorbid conditions with life expectancy less than 12 months or that may result in protocol noncompliance\nKnown allergy to the study medications (probucol, sirolimus, zotarolimus)\nPregnancy (present, suspected, or planned)\n" ], "offsets": [ [ 0, 324 ] ] } ]

[ { "id": "NCT03026465_exc_T1", "type": "Condition", "text": [ "Target lesion" ], "offsets": [ [ 0, 13 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T2", "type": "Qualifier", "text": [ "left main stem" ], "offsets": [ [ 29, 43 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T3", "type": "Condition", "text": [ "STEMI" ], "offsets": [ [ 44, 49 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T4", "type": "Condition", "text": [ "Restenosis" ], "offsets": [ [ 50, 60 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T5", "type": "Condition", "text": [ "Cardiogenic shock" ], "offsets": [ [ 61, 78 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T6", "type": "Condition", "text": [ "Malignancies" ], "offsets": [ [ 79, 91 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T7", "type": "Condition", "text": [ "comorbid conditions" ], "offsets": [ [ 101, 120 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T8", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 95, 100 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T9", "type": "Observation", "text": [ "life expectancy" ], "offsets": [ [ 126, 141 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T10", "type": "Value", "text": [ "less than 12 months" ], "offsets": [ [ 142, 161 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T11", "type": "Observation", "text": [ "protocol noncompliance" ], "offsets": [ [ 184, 206 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T12", "type": "Mood", "text": [ "may" ], "offsets": [ [ 170, 173 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T13", "type": "Scope", "text": [ "life expectancy less than 12 months or that may result in protocol noncompliance" ], "offsets": [ [ 126, 206 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T14", "type": "Scope", "text": [ "Malignancies or other comorbid conditions" ], "offsets": [ [ 79, 120 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T15", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 213, 220 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T16", "type": "Drug", "text": [ "study medications" ], "offsets": [ [ 228, 245 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T17", "type": "Drug", "text": [ "probucol" ], "offsets": [ [ 247, 255 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T18", "type": "Drug", "text": [ "sirolimus" ], "offsets": [ [ 257, 266 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T19", "type": "Drug", "text": [ "zotarolimus" ], "offsets": [ [ 268, 279 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T20", "type": "Scope", "text": [ "probucol, sirolimus, zotarolimus" ], "offsets": [ [ 247, 279 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T21", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 281, 290 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T22", "type": "Temporal", "text": [ "present" ], "offsets": [ [ 292, 299 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T23", "type": "Mood", "text": [ "suspected" ], "offsets": [ [ 301, 310 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T24", "type": "Mood", "text": [ "planned" ], "offsets": [ [ 315, 322 ] ], "normalized": [] }, { "id": "NCT03026465_exc_T25", "type": "Scope", "text": [ "present, suspected, or planned" ], "offsets": [ [ 292, 322 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03026465_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03026465_exc_T1", "arg2_id": "NCT03026465_exc_T2", "normalized": [] }, { "id": "NCT03026465_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03026465_exc_T7", "arg2_id": "NCT03026465_exc_T8", "normalized": [] }, { "id": "NCT03026465_exc_R3", "type": "Has_mood", "arg1_id": "NCT03026465_exc_T11", "arg2_id": "NCT03026465_exc_T12", "normalized": [] }, { "id": "NCT03026465_exc_R4", "type": "Has_value", "arg1_id": "NCT03026465_exc_T9", "arg2_id": "NCT03026465_exc_T10", "normalized": [] }, { "id": "NCT03026465_exc_R5", "type": "Has_scope", "arg1_id": "NCT03026465_exc_T14", "arg2_id": "NCT03026465_exc_T13", "normalized": [] }, { "id": "NCT03026465_exc_R6", "type": "Subsumes", "arg1_id": "NCT03026465_exc_T16", "arg2_id": "NCT03026465_exc_T20", "normalized": [] }, { "id": "NCT03026465_exc_R7", "type": "AND", "arg1_id": "NCT03026465_exc_T15", "arg2_id": "NCT03026465_exc_T16", "normalized": [] }, { "id": "NCT03026465_exc_R8", "type": "Has_scope", "arg1_id": "NCT03026465_exc_T21", "arg2_id": "NCT03026465_exc_T25", "normalized": [] } ]

[ { "id": "NCT03026465_inc_text", "type": "inclusion", "text": [ "Patients older than 18 years\nIschemic symptoms or evidence of myocardial ischemia (inducible or spontaneous) in the presence of >50% de novo stenosis located in native coronary vessels\n" ], "offsets": [ [ 0, 185 ] ] } ]

[ { "id": "NCT03026465_inc_T1", "type": "Person", "text": [ "years" ], "offsets": [ [ 23, 28 ] ], "normalized": [] }, { "id": "NCT03026465_inc_T2", "type": "Value", "text": [ "older than 18" ], "offsets": [ [ 9, 22 ] ], "normalized": [] }, { "id": "NCT03026465_inc_T3", "type": "Condition", "text": [ "Ischemic symptoms" ], "offsets": [ [ 29, 46 ] ], "normalized": [] }, { "id": "NCT03026465_inc_T4", "type": "Mood", "text": [ "evidence" ], "offsets": [ [ 50, 58 ] ], "normalized": [] }, { "id": "NCT03026465_inc_T5", "type": "Condition", "text": [ "myocardial ischemia" ], "offsets": [ [ 62, 81 ] ], "normalized": [] }, { "id": "NCT03026465_inc_T6", "type": "Qualifier", "text": [ "inducible" ], "offsets": [ [ 83, 92 ] ], "normalized": [] }, { "id": "NCT03026465_inc_T7", "type": "Qualifier", "text": [ "spontaneous" ], "offsets": [ [ 96, 107 ] ], "normalized": [] }, { "id": "NCT03026465_inc_T8", "type": "Scope", "text": [ "inducible or spontaneous" ], "offsets": [ [ 83, 107 ] ], "normalized": [] }, { "id": "NCT03026465_inc_T9", "type": "Value", "text": [ ">50%" ], "offsets": [ [ 128, 132 ] ], "normalized": [] }, { "id": "NCT03026465_inc_T10", "type": "Qualifier", "text": [ "de novo" ], "offsets": [ [ 133, 140 ] ], "normalized": [] }, { "id": "NCT03026465_inc_T11", "type": "Measurement", "text": [ "stenosis" ], "offsets": [ [ 141, 149 ] ], "normalized": [] }, { "id": "NCT03026465_inc_T12", "type": "Condition", "text": [ "stenosis" ], "offsets": [ [ 141, 149 ] ], "normalized": [] }, { "id": "NCT03026465_inc_T13", "type": "Qualifier", "text": [ "native coronary vessels" ], "offsets": [ [ 161, 184 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03026465_inc_R1", "type": "Has_value", "arg1_id": "NCT03026465_inc_T1", "arg2_id": "NCT03026465_inc_T2", "normalized": [] }, { "id": "NCT03026465_inc_R2", "type": "Has_scope", "arg1_id": "NCT03026465_inc_T5", "arg2_id": "NCT03026465_inc_T8", "normalized": [] }, { "id": "NCT03026465_inc_R3", "type": "Has_mood", "arg1_id": "NCT03026465_inc_T5", "arg2_id": "NCT03026465_inc_T4", "normalized": [] }, { "id": "NCT03026465_inc_R4", "type": "Has_value", "arg1_id": "NCT03026465_inc_T11", "arg2_id": "NCT03026465_inc_T9", "normalized": [] }, { "id": "NCT03026465_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT03026465_inc_T11", "arg2_id": "NCT03026465_inc_T10", "normalized": [] }, { "id": "NCT03026465_inc_R6", "type": "AND", "arg1_id": "NCT03026465_inc_T12", "arg2_id": "NCT03026465_inc_T11", "normalized": [] }, { "id": "NCT03026465_inc_R8", "type": "Has_qualifier", "arg1_id": "NCT03026465_inc_T12", "arg2_id": "NCT03026465_inc_T13", "normalized": [] }, { "id": "NCT03026465_inc_R9", "type": "AND", "arg1_id": "NCT03026465_inc_T5", "arg2_id": "NCT03026465_inc_T12", "normalized": [] } ]

[ { "id": "NCT03027115_exc_text", "type": "exclusion", "text": [ "Intolerability of tamsulosin or related drugs\nInvestigator discretion\nUnwillingness or inability to comply with protocol procedures and assessments\n" ], "offsets": [ [ 0, 148 ] ] } ]

[ { "id": "NCT03027115_exc_T1", "type": "Condition", "text": [ "Intolerability" ], "offsets": [ [ 0, 14 ] ], "normalized": [] }, { "id": "NCT03027115_exc_T2", "type": "Drug", "text": [ "tamsulosin" ], "offsets": [ [ 18, 28 ] ], "normalized": [] }, { "id": "NCT03027115_exc_T3", "type": "Drug", "text": [ "related drugs" ], "offsets": [ [ 32, 45 ] ], "normalized": [] }, { "id": "NCT03027115_exc_T4", "type": "Scope", "text": [ "tamsulosin or related drugs" ], "offsets": [ [ 18, 45 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03027115_exc_R1", "type": "Has_scope", "arg1_id": "NCT03027115_exc_T1", "arg2_id": "NCT03027115_exc_T4", "normalized": [] } ]

[ { "id": "NCT03027115_inc_text", "type": "inclusion", "text": [ "Male\n18 years of age\nPresenting with hernia requiring surgical intervention\n" ], "offsets": [ [ 0, 76 ] ] } ]

[ { "id": "NCT03027115_inc_T1", "type": "Person", "text": [ "Male" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "NCT03027115_inc_T2", "type": "Value", "text": [ "18 years" ], "offsets": [ [ 5, 13 ] ], "normalized": [] }, { "id": "NCT03027115_inc_T3", "type": "Person", "text": [ "age" ], "offsets": [ [ 17, 20 ] ], "normalized": [] }, { "id": "NCT03027115_inc_T4", "type": "Condition", "text": [ "hernia" ], "offsets": [ [ 37, 43 ] ], "normalized": [] }, { "id": "NCT03027115_inc_T5", "type": "Mood", "text": [ "requiring" ], "offsets": [ [ 44, 53 ] ], "normalized": [] }, { "id": "NCT03027115_inc_T6", "type": "Procedure", "text": [ "surgical intervention" ], "offsets": [ [ 54, 75 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03027115_inc_R1", "type": "Has_value", "arg1_id": "NCT03027115_inc_T3", "arg2_id": "NCT03027115_inc_T2", "normalized": [] }, { "id": "NCT03027115_inc_R2", "type": "Has_mood", "arg1_id": "NCT03027115_inc_T6", "arg2_id": "NCT03027115_inc_T5", "normalized": [] }, { "id": "NCT03027115_inc_R3", "type": "AND", "arg1_id": "NCT03027115_inc_T4", "arg2_id": "NCT03027115_inc_T6", "normalized": [] } ]

[ { "id": "NCT03029078_exc_text", "type": "exclusion", "text": [ "Pregnant woman or breastfeeding\nimmunosuppression including AIDS, corticosteroids over 60mg/day\nongoing antibiotic treatment at the day of inclusion\nimpossibility to obtain a signed consent form.\n" ], "offsets": [ [ 0, 196 ] ] } ]

[ { "id": "NCT03029078_exc_T1", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT03029078_exc_T2", "type": "Person", "text": [ "woman" ], "offsets": [ [ 9, 14 ] ], "normalized": [] }, { "id": "NCT03029078_exc_T3", "type": "Observation", "text": [ "breastfeeding" ], "offsets": [ [ 18, 31 ] ], "normalized": [] }, { "id": "NCT03029078_exc_T4", "type": "Condition", "text": [ "immunosuppression" ], "offsets": [ [ 32, 49 ] ], "normalized": [] }, { "id": "NCT03029078_exc_T5", "type": "Condition", "text": [ "AIDS" ], "offsets": [ [ 60, 64 ] ], "normalized": [] }, { "id": "NCT03029078_exc_T6", "type": "Drug", "text": [ "corticosteroids" ], "offsets": [ [ 66, 81 ] ], "normalized": [] }, { "id": "NCT03029078_exc_T7", "type": "Multiplier", "text": [ "over 60mg/day" ], "offsets": [ [ 82, 95 ] ], "normalized": [] }, { "id": "NCT03029078_exc_T8", "type": "Scope", "text": [ "AIDS, corticosteroids over 60mg/day" ], "offsets": [ [ 60, 95 ] ], "normalized": [] }, { "id": "NCT03029078_exc_T9", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 115, 124 ] ], "normalized": [] }, { "id": "NCT03029078_exc_T10", "type": "Drug", "text": [ "antibiotic" ], "offsets": [ [ 104, 114 ] ], "normalized": [] }, { "id": "NCT03029078_exc_T11", "type": "Temporal", "text": [ "at the day of inclusion" ], "offsets": [ [ 125, 148 ] ], "normalized": [] }, { "id": "NCT03029078_exc_T12", "type": "Observation", "text": [ "signed consent form" ], "offsets": [ [ 175, 194 ] ], "normalized": [] }, { "id": "NCT03029078_exc_T14", "type": "Condition", "text": [ "impossibility to obtain" ], "offsets": [ [ 149, 172 ] ], "normalized": [] }, { "id": "NCT03029078_exc_T13", "type": "Reference_point", "text": [ "day of inclusion" ], "offsets": [ [ 132, 148 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03029078_exc_R1", "type": "Has_multiplier", "arg1_id": "NCT03029078_exc_T6", "arg2_id": "NCT03029078_exc_T7", "normalized": [] }, { "id": "NCT03029078_exc_R2", "type": "Subsumes", "arg1_id": "NCT03029078_exc_T4", "arg2_id": "NCT03029078_exc_T8", "normalized": [] }, { "id": "NCT03029078_exc_R3", "type": "AND", "arg1_id": "NCT03029078_exc_T9", "arg2_id": "NCT03029078_exc_T10", "normalized": [] }, { "id": "NCT03029078_exc_R4", "type": "Has_temporal", "arg1_id": "NCT03029078_exc_T9", "arg2_id": "NCT03029078_exc_T11", "normalized": [] }, { "id": "NCT03029078_exc_R5", "type": "Has_index", "arg1_id": "NCT03029078_exc_T11", "arg2_id": "NCT03029078_exc_T13", "normalized": [] } ]

[ { "id": "NCT03029078_inc_text", "type": "inclusion", "text": [ "Patient harboring a GRE or CRE bacteria\nColonization confirmed by our microbiology department, including at least 3 positives swabs in the last month\n" ], "offsets": [ [ 0, 150 ] ] } ]

[ { "id": "NCT03029078_inc_T1", "type": "Condition", "text": [ "CRE bacteria" ], "offsets": [ [ 27, 39 ] ], "normalized": [] }, { "id": "NCT03029078_inc_T2", "type": "Condition", "text": [ "GRE", "bacteria" ], "offsets": [ [ 20, 23 ], [ 31, 39 ] ], "normalized": [] }, { "id": "NCT03029078_inc_T3", "type": "Multiplier", "text": [ "at least 3" ], "offsets": [ [ 105, 115 ] ], "normalized": [] }, { "id": "NCT03029078_inc_T4", "type": "Value", "text": [ "positives" ], "offsets": [ [ 116, 125 ] ], "normalized": [] }, { "id": "NCT03029078_inc_T5", "type": "Procedure", "text": [ "swabs" ], "offsets": [ [ 126, 131 ] ], "normalized": [] }, { "id": "NCT03029078_inc_T6", "type": "Temporal", "text": [ "in the last mont" ], "offsets": [ [ 132, 148 ] ], "normalized": [] }, { "id": "NCT03029078_inc_T7", "type": "Condition", "text": [ "Colonization" ], "offsets": [ [ 40, 52 ] ], "normalized": [] }, { "id": "NCT03029078_inc_T8", "type": "Qualifier", "text": [ "confirmed by our microbiology department" ], "offsets": [ [ 53, 93 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03029078_inc_R1", "type": "Has_temporal", "arg1_id": "NCT03029078_inc_T5", "arg2_id": "NCT03029078_inc_T6", "normalized": [] }, { "id": "NCT03029078_inc_R2", "type": "Has_multiplier", "arg1_id": "NCT03029078_inc_T5", "arg2_id": "NCT03029078_inc_T3", "normalized": [] }, { "id": "NCT03029078_inc_R3", "type": "Has_value", "arg1_id": "NCT03029078_inc_T5", "arg2_id": "NCT03029078_inc_T4", "normalized": [] }, { "id": "NCT03029078_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT03029078_inc_T7", "arg2_id": "NCT03029078_inc_T8", "normalized": [] }, { "id": "NCT03029078_inc_R5", "type": "AND", "arg1_id": "NCT03029078_inc_T7", "arg2_id": "NCT03029078_inc_T5", "normalized": [] } ]

[ { "id": "NCT03033745_exc_text", "type": "exclusion", "text": [ "Ongoing serious bacterial infections at the time of screening.\nOther significant medical conditions that could increase the risk to the subject.\nFemales who are pregnant, breast feeding, or planning a pregnancy during the course study.\nParticipation in a study with an Investigational Medicinal Product (IMP) other than IgPro20 within three months prior to enrollment.\n" ], "offsets": [ [ 0, 369 ] ] } ]

[ { "id": "NCT03033745_exc_T1", "type": "Condition", "text": [ "bacterial infections" ], "offsets": [ [ 16, 36 ] ], "normalized": [] }, { "id": "NCT03033745_exc_T2", "type": "Qualifier", "text": [ "serious" ], "offsets": [ [ 8, 15 ] ], "normalized": [] }, { "id": "NCT03033745_exc_T3", "type": "Temporal", "text": [ "at the time of screening" ], "offsets": [ [ 37, 61 ] ], "normalized": [] }, { "id": "NCT03033745_exc_T4", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 52, 61 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03033745_exc_R1", "type": "Has_index", "arg1_id": "NCT03033745_exc_T3", "arg2_id": "NCT03033745_exc_T4", "normalized": [] }, { "id": "NCT03033745_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03033745_exc_T1", "arg2_id": "NCT03033745_exc_T2", "normalized": [] }, { "id": "NCT03033745_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03033745_exc_T1", "arg2_id": "NCT03033745_exc_T3", "normalized": [] } ]

[ { "id": "NCT03033745_inc_text", "type": "inclusion", "text": [ "Male or female on stable dose of IgPro20 (Hizentra) therapy.\nWomen of childbearing potential must be using and agree to continue using medically approved contraception (which must be discussed with the study doctor) and must have a negative pregnancy test at screening.\nSubjects with PID, eg, with a diagnosis of common variable immunodeficiency or X-linked agammaglobulinemia, as defined by the Pan American Group for Immune Deficiency and the European Society of Immune Deficiencies.\nWith infusion parameters as specified below:\nExperience with pump-assisted infusions of IgPro20 at the tolerated flow rate of 25 mL/h per injection site for at least 1 month prior to Day 1.\nTotal weekly IgPro20 dose of = 50 mL (= 10 g).\nExperience with pump-assisted infusions of IgPro20 at tolerated volumes of 25 mL/injection site for at least 1 month prior to Day 1.\nExperience with frequent (2-7 times per week) infusions of IgPro20 at the tolerated flow rate of approximately 0.5 mL/min (equivalent of 25-30 mL/h) per injection site for at least 1 month prior to Day 1. The dose (volume) per injection site should not exceed 25 mL.\n" ], "offsets": [ [ 0, 1123 ] ] } ]

[ { "id": "NCT03033745_inc_T1", "type": "Person", "text": [ "Male" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T2", "type": "Person", "text": [ "female" ], "offsets": [ [ 8, 14 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T3", "type": "Drug", "text": [ "IgPro20" ], "offsets": [ [ 33, 40 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T4", "type": "Drug", "text": [ "Hizentra" ], "offsets": [ [ 42, 50 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T5", "type": "Qualifier", "text": [ "stable dose" ], "offsets": [ [ 18, 29 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T7", "type": "Condition", "text": [ "PID" ], "offsets": [ [ 284, 287 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T8", "type": "Condition", "text": [ "common variable immunodeficiency" ], "offsets": [ [ 313, 345 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T9", "type": "Condition", "text": [ "X-linked agammaglobulinemia" ], "offsets": [ [ 349, 376 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T10", "type": "Measurement", "text": [ "Pan American Group for Immune Deficiency" ], "offsets": [ [ 396, 436 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T11", "type": "Measurement", "text": [ "European Society of Immune Deficiencies" ], "offsets": [ [ 445, 484 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T13", "type": "Scope", "text": [ "Pan American Group for Immune Deficiency and the European Society of Immune Deficiencies" ], "offsets": [ [ 396, 484 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T14", "type": "Scope", "text": [ "common variable immunodeficiency or X-linked agammaglobulinemia" ], "offsets": [ [ 313, 376 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T15", "type": "Qualifier", "text": [ "pump-assisted infusions" ], "offsets": [ [ 547, 570 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T16", "type": "Drug", "text": [ "IgPro20" ], "offsets": [ [ 574, 581 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T17", "type": "Multiplier", "text": [ "flow rate of 25 mL/h per injection site" ], "offsets": [ [ 599, 638 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T18", "type": "Qualifier", "text": [ "tolerated" ], "offsets": [ [ 589, 598 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T19", "type": "Temporal", "text": [ "for at least 1 month prior to Day 1" ], "offsets": [ [ 639, 674 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T20", "type": "Reference_point", "text": [ "Day 1" ], "offsets": [ [ 669, 674 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T21", "type": "Qualifier", "text": [ "weekly" ], "offsets": [ [ 682, 688 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T22", "type": "Drug", "text": [ "IgPro20" ], "offsets": [ [ 689, 696 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T23", "type": "Multiplier", "text": [ "= 50 mL" ], "offsets": [ [ 705, 712 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T24", "type": "Multiplier", "text": [ "= 10 g" ], "offsets": [ [ 714, 720 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T25", "type": "Qualifier", "text": [ "pump-assisted infusions" ], "offsets": [ [ 739, 762 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T26", "type": "Drug", "text": [ "IgPro20" ], "offsets": [ [ 766, 773 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T27", "type": "Multiplier", "text": [ "volumes of 25 mL/injection site" ], "offsets": [ [ 787, 818 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T28", "type": "Qualifier", "text": [ "tolerated" ], "offsets": [ [ 777, 786 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T29", "type": "Temporal", "text": [ "for at least 1 month prior to Day 1" ], "offsets": [ [ 819, 854 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T30", "type": "Reference_point", "text": [ "Day 1" ], "offsets": [ [ 849, 854 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T31", "type": "Qualifier", "text": [ "frequent" ], "offsets": [ [ 872, 880 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T32", "type": "Drug", "text": [ "IgPro20" ], "offsets": [ [ 915, 922 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T33", "type": "Multiplier", "text": [ "ection site for at", "te of approximately 0.5 mL/min (equiv" ], "offsets": [ [ 1012, 1030 ], [ 947, 984 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T34", "type": "Multiplier", "text": [ "25-30 mL/h" ], "offsets": [ [ 993, 1003 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T35", "type": "Temporal", "text": [ "for at least 1 month prior to Day 1" ], "offsets": [ [ 1024, 1059 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T36", "type": "Reference_point", "text": [ "Day 1" ], "offsets": [ [ 1054, 1059 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T37", "type": "Multiplier", "text": [ "2-7 times per week" ], "offsets": [ [ 882, 900 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T38", "type": "Negation", "text": [ "not" ], "offsets": [ [ 1105, 1108 ] ], "normalized": [] }, { "id": "NCT03033745_inc_T39", "type": "Multiplier", "text": [ "exceed 25 mL." ], "offsets": [ [ 1109, 1122 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03033745_inc_R1", "type": "Subsumes", "arg1_id": "NCT03033745_inc_T3", "arg2_id": "NCT03033745_inc_T4", "normalized": [] }, { "id": "NCT03033745_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03033745_inc_T3", "arg2_id": "NCT03033745_inc_T5", "normalized": [] }, { "id": "NCT03033745_inc_R3", "type": "Has_scope", "arg1_id": "NCT03033745_inc_T13", "arg2_id": "NCT03033745_inc_T14", "normalized": [] }, { "id": "NCT03033745_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT03033745_inc_T16", "arg2_id": "NCT03033745_inc_T15", "normalized": [] }, { "id": "NCT03033745_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT03033745_inc_T17", "arg2_id": "NCT03033745_inc_T18", "normalized": [] }, { "id": "NCT03033745_inc_R6", "type": "Has_multiplier", "arg1_id": "NCT03033745_inc_T16", "arg2_id": "NCT03033745_inc_T17", "normalized": [] }, { "id": "NCT03033745_inc_R7", "type": "Has_index", "arg1_id": "NCT03033745_inc_T19", "arg2_id": "NCT03033745_inc_T20", "normalized": [] }, { "id": "NCT03033745_inc_R8", "type": "Has_temporal", "arg1_id": "NCT03033745_inc_T16", "arg2_id": "NCT03033745_inc_T19", "normalized": [] }, { "id": "NCT03033745_inc_R9", "type": "Subsumes", "arg1_id": "NCT03033745_inc_T23", "arg2_id": "NCT03033745_inc_T24", "normalized": [] }, { "id": "NCT03033745_inc_R10", "type": "Has_qualifier", "arg1_id": "NCT03033745_inc_T22", "arg2_id": "NCT03033745_inc_T21", "normalized": [] }, { "id": "NCT03033745_inc_R11", "type": "Has_multiplier", "arg1_id": "NCT03033745_inc_T22", "arg2_id": "NCT03033745_inc_T23", "normalized": [] }, { "id": "NCT03033745_inc_R12", "type": "Has_index", "arg1_id": "NCT03033745_inc_T29", "arg2_id": "NCT03033745_inc_T30", "normalized": [] }, { "id": "NCT03033745_inc_R13", "type": "Has_qualifier", "arg1_id": "NCT03033745_inc_T27", "arg2_id": "NCT03033745_inc_T28", "normalized": [] }, { "id": "NCT03033745_inc_R14", "type": "Has_multiplier", "arg1_id": "NCT03033745_inc_T26", "arg2_id": "NCT03033745_inc_T27", "normalized": [] }, { "id": "NCT03033745_inc_R15", "type": "Has_temporal", "arg1_id": "NCT03033745_inc_T26", "arg2_id": "NCT03033745_inc_T29", "normalized": [] }, { "id": "NCT03033745_inc_R16", "type": "Has_qualifier", "arg1_id": "NCT03033745_inc_T26", "arg2_id": "NCT03033745_inc_T25", "normalized": [] }, { "id": "NCT03033745_inc_R17", "type": "Has_qualifier", "arg1_id": "NCT03033745_inc_T32", "arg2_id": "NCT03033745_inc_T31", "normalized": [] }, { "id": "NCT03033745_inc_R18", "type": "Has_multiplier", "arg1_id": "NCT03033745_inc_T32", "arg2_id": "NCT03033745_inc_T37", "normalized": [] }, { "id": "NCT03033745_inc_R19", "type": "Has_multiplier", "arg1_id": "NCT03033745_inc_T32", "arg2_id": "NCT03033745_inc_T33", "normalized": [] }, { "id": "NCT03033745_inc_R20", "type": "Subsumes", "arg1_id": "NCT03033745_inc_T33", "arg2_id": "NCT03033745_inc_T34", "normalized": [] }, { "id": "NCT03033745_inc_R21", "type": "Has_temporal", "arg1_id": "NCT03033745_inc_T32", "arg2_id": "NCT03033745_inc_T35", "normalized": [] }, { "id": "NCT03033745_inc_R22", "type": "Has_index", "arg1_id": "NCT03033745_inc_T35", "arg2_id": "NCT03033745_inc_T36", "normalized": [] }, { "id": "NCT03033745_inc_R23", "type": "Has_negation", "arg1_id": "NCT03033745_inc_T39", "arg2_id": "NCT03033745_inc_T38", "normalized": [] }, { "id": "NCT03033745_inc_R24", "type": "Has_multiplier", "arg1_id": "NCT03033745_inc_T32", "arg2_id": "NCT03033745_inc_T39", "normalized": [] } ]

[ { "id": "NCT03034096_exc_text", "type": "exclusion", "text": [ "Age less than 18 years\nAmerican Society of Anesthesiologist Class 5\nProjected life expectancy less than 30 days\nKnown or suspected hypersensitivity to either propofol, e.g. egg or soy allergy, or volatile general anesthetic agents\nKnown or suspected history of malignant hyperthermia\n" ], "offsets": [ [ 0, 284 ] ] } ]

[ { "id": "NCT03034096_exc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03034096_exc_T2", "type": "Value", "text": [ "less than 18 years" ], "offsets": [ [ 4, 22 ] ], "normalized": [] }, { "id": "NCT03034096_exc_T3", "type": "Measurement", "text": [ "American Society of Anesthesiologist Class" ], "offsets": [ [ 23, 65 ] ], "normalized": [] }, { "id": "NCT03034096_exc_T4", "type": "Value", "text": [ "5" ], "offsets": [ [ 66, 67 ] ], "normalized": [] }, { "id": "NCT03034096_exc_T5", "type": "Observation", "text": [ "Projected life expectancy" ], "offsets": [ [ 68, 93 ] ], "normalized": [] }, { "id": "NCT03034096_exc_T6", "type": "Value", "text": [ "less than 30 days" ], "offsets": [ [ 94, 111 ] ], "normalized": [] }, { "id": "NCT03034096_exc_T7", "type": "Mood", "text": [ "Known" ], "offsets": [ [ 112, 117 ] ], "normalized": [] }, { "id": "NCT03034096_exc_T8", "type": "Mood", "text": [ "suspected" ], "offsets": [ [ 121, 130 ] ], "normalized": [] }, { "id": "NCT03034096_exc_T9", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 131, 147 ] ], "normalized": [] }, { "id": "NCT03034096_exc_T10", "type": "Drug", "text": [ "propofol" ], "offsets": [ [ 158, 166 ] ], "normalized": [] }, { "id": "NCT03034096_exc_T11", "type": "Drug", "text": [ "egg" ], "offsets": [ [ 173, 176 ] ], "normalized": [] }, { "id": "NCT03034096_exc_T12", "type": "Drug", "text": [ "soy" ], "offsets": [ [ 180, 183 ] ], "normalized": [] }, { "id": "NCT03034096_exc_T13", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 184, 191 ] ], "normalized": [] }, { "id": "NCT03034096_exc_T14", "type": "Drug", "text": [ "volatile general anesthetic agents" ], "offsets": [ [ 196, 230 ] ], "normalized": [] }, { "id": "NCT03034096_exc_T15", "type": "Scope", "text": [ "egg or soy" ], "offsets": [ [ 173, 183 ] ], "normalized": [] }, { "id": "NCT03034096_exc_T16", "type": "Scope", "text": [ "pofol, e", "atile general anesthetic agents\nKn" ], "offsets": [ [ 161, 169 ], [ 199, 233 ] ], "normalized": [] }, { "id": "NCT03034096_exc_T17", "type": "Scope", "text": [ "Known or suspected" ], "offsets": [ [ 112, 130 ] ], "normalized": [] }, { "id": "NCT03034096_exc_T19", "type": "Condition", "text": [ "malignant hyperthermia" ], "offsets": [ [ 261, 283 ] ], "normalized": [] }, { "id": "NCT03034096_exc_T18", "type": "Mood", "text": [ "Known" ], "offsets": [ [ 231, 236 ] ], "normalized": [] }, { "id": "NCT03034096_exc_T20", "type": "Mood", "text": [ "suspected" ], "offsets": [ [ 240, 249 ] ], "normalized": [] }, { "id": "NCT03034096_exc_T21", "type": "Observation", "text": [ "history" ], "offsets": [ [ 250, 257 ] ], "normalized": [] }, { "id": "NCT03034096_exc_T22", "type": "Scope", "text": [ "Known or suspected" ], "offsets": [ [ 231, 249 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03034096_exc_R1", "type": "Has_value", "arg1_id": "NCT03034096_exc_T1", "arg2_id": "NCT03034096_exc_T2", "normalized": [] }, { "id": "NCT03034096_exc_R2", "type": "Has_value", "arg1_id": "NCT03034096_exc_T3", "arg2_id": "NCT03034096_exc_T4", "normalized": [] }, { "id": "NCT03034096_exc_R3", "type": "Has_value", "arg1_id": "NCT03034096_exc_T5", "arg2_id": "NCT03034096_exc_T6", "normalized": [] }, { "id": "NCT03034096_exc_R4", "type": "Has_scope", "arg1_id": "NCT03034096_exc_T13", "arg2_id": "NCT03034096_exc_T15", "normalized": [] }, { "id": "NCT03034096_exc_R5", "type": "Has_scope", "arg1_id": "NCT03034096_exc_T9", "arg2_id": "NCT03034096_exc_T16", "normalized": [] }, { "id": "NCT03034096_exc_R6", "type": "Has_scope", "arg1_id": "NCT03034096_exc_T9", "arg2_id": "NCT03034096_exc_T17", "normalized": [] }, { "id": "NCT03034096_exc_R7", "type": "Has_temporal", "arg1_id": "NCT03034096_exc_T19", "arg2_id": "NCT03034096_exc_T21", "normalized": [] }, { "id": "NCT03034096_exc_R8", "type": "Has_scope", "arg1_id": "NCT03034096_exc_T19", "arg2_id": "NCT03034096_exc_T22", "normalized": [] } ]

[ { "id": "NCT03034096_inc_text", "type": "inclusion", "text": [ "Lobectomy or pneumonectomy\nEsophagectomy\nRadical (total) cystectomy\nPancreatectomy\nPartial hepatectomy\nHyperthermic intraperitoneal chemotherapy (HIPEC)\nGastrectomy (subtotal or total)\nCholecystectomy or bile duct resection\n" ], "offsets": [ [ 0, 224 ] ] } ]

[ { "id": "NCT03034096_inc_T1", "type": "Procedure", "text": [ "Lobectomy" ], "offsets": [ [ 0, 9 ] ], "normalized": [] }, { "id": "NCT03034096_inc_T2", "type": "Procedure", "text": [ "pneumonectomy" ], "offsets": [ [ 13, 26 ] ], "normalized": [] }, { "id": "NCT03034096_inc_T3", "type": "Procedure", "text": [ "Esophagectomy" ], "offsets": [ [ 27, 40 ] ], "normalized": [] }, { "id": "NCT03034096_inc_T4", "type": "Procedure", "text": [ "dical (", "stectomy\nP" ], "offsets": [ [ 43, 50 ], [ 59, 69 ] ], "normalized": [] }, { "id": "NCT03034096_inc_T5", "type": "Procedure", "text": [ "Pancreatectomy" ], "offsets": [ [ 68, 82 ] ], "normalized": [] }, { "id": "NCT03034096_inc_T6", "type": "Procedure", "text": [ "tal)", "stectomy\nP" ], "offsets": [ [ 52, 56 ], [ 59, 69 ] ], "normalized": [] }, { "id": "NCT03034096_inc_T7", "type": "Procedure", "text": [ "Partial hepatectomy" ], "offsets": [ [ 83, 102 ] ], "normalized": [] }, { "id": "NCT03034096_inc_T8", "type": "Procedure", "text": [ "Hyperthermic intraperitoneal chemotherapy" ], "offsets": [ [ 103, 144 ] ], "normalized": [] }, { "id": "NCT03034096_inc_T9", "type": "Procedure", "text": [ "HIPEC" ], "offsets": [ [ 146, 151 ] ], "normalized": [] }, { "id": "NCT03034096_inc_T10", "type": "Procedure", "text": [ "Gastrectomy" ], "offsets": [ [ 153, 164 ] ], "normalized": [] }, { "id": "NCT03034096_inc_T11", "type": "Qualifier", "text": [ "subtotal" ], "offsets": [ [ 166, 174 ] ], "normalized": [] }, { "id": "NCT03034096_inc_T12", "type": "Qualifier", "text": [ "total" ], "offsets": [ [ 178, 183 ] ], "normalized": [] }, { "id": "NCT03034096_inc_T13", "type": "Scope", "text": [ "subtotal or total" ], "offsets": [ [ 166, 183 ] ], "normalized": [] }, { "id": "NCT03034096_inc_T14", "type": "Procedure", "text": [ "Cholecystectomy" ], "offsets": [ [ 185, 200 ] ], "normalized": [] }, { "id": "NCT03034096_inc_T15", "type": "Procedure", "text": [ "bile duct resection" ], "offsets": [ [ 204, 223 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03034096_inc_R1", "type": "Subsumes", "arg1_id": "NCT03034096_inc_T4", "arg2_id": "NCT03034096_inc_T6", "normalized": [] }, { "id": "NCT03034096_inc_R2", "type": "Subsumes", "arg1_id": "NCT03034096_inc_T8", "arg2_id": "NCT03034096_inc_T9", "normalized": [] }, { "id": "NCT03034096_inc_R3", "type": "Has_scope", "arg1_id": "NCT03034096_inc_T10", "arg2_id": "NCT03034096_inc_T13", "normalized": [] } ]

[ { "id": "NCT03034733_exc_text", "type": "exclusion", "text": [ "severe coronary artery disease, heart failure, kidney failure\ninsulin-dependent DM (diabetes mellitus), poorly controlled type II DM\ngastric/duodenal ulcer\nallergy/contra-indication for any drug used in the study\ncorticosteroid use during last 3 months\npreoperative use of opioid drugs (excl. codeine, tramadol)\nneuropathy/sensory impairment of lower limbs\nlack of co-operation, e.g. inability to use a PCA (patient controlled analgesia)-device\n" ], "offsets": [ [ 0, 445 ] ] } ]

[ { "id": "NCT03034733_exc_T1", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T2", "type": "Condition", "text": [ "coronary artery disease" ], "offsets": [ [ 7, 30 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T3", "type": "Condition", "text": [ "heart failure" ], "offsets": [ [ 32, 45 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T4", "type": "Condition", "text": [ "kidney failure" ], "offsets": [ [ 47, 61 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T5", "type": "Scope", "text": [ "coronary artery disease, heart failure, kidney failure" ], "offsets": [ [ 7, 61 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T6", "type": "Condition", "text": [ "insulin-dependent DM" ], "offsets": [ [ 62, 82 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T7", "type": "Condition", "text": [ "diabetes mellitus" ], "offsets": [ [ 84, 101 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T8", "type": "Qualifier", "text": [ "poorly controlled" ], "offsets": [ [ 104, 121 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T9", "type": "Condition", "text": [ "type II DM" ], "offsets": [ [ 122, 132 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T10", "type": "Condition", "text": [ "stric/d", "cer\na" ], "offsets": [ [ 135, 142 ], [ 152, 157 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T11", "type": "Condition", "text": [ "duodenal ulcer" ], "offsets": [ [ 141, 155 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T12", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 156, 163 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T13", "type": "Condition", "text": [ "contra-indication" ], "offsets": [ [ 164, 181 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T14", "type": "Drug", "text": [ "drug used in the study" ], "offsets": [ [ 190, 212 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T15", "type": "Scope", "text": [ "allergy/contra-indication" ], "offsets": [ [ 156, 181 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T16", "type": "Drug", "text": [ "corticosteroid" ], "offsets": [ [ 213, 227 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T17", "type": "Temporal", "text": [ "during last 3 months" ], "offsets": [ [ 232, 252 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T18", "type": "Temporal", "text": [ "preoperative" ], "offsets": [ [ 253, 265 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T19", "type": "Drug", "text": [ "opioid drugs" ], "offsets": [ [ 273, 285 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T20", "type": "Negation", "text": [ "excl." ], "offsets": [ [ 287, 292 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T21", "type": "Drug", "text": [ "codeine" ], "offsets": [ [ 293, 300 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T22", "type": "Drug", "text": [ "tramadol" ], "offsets": [ [ 302, 310 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T23", "type": "Scope", "text": [ "codeine, tramadol" ], "offsets": [ [ 293, 310 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T24", "type": "Condition", "text": [ "neuropathy" ], "offsets": [ [ 312, 322 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T25", "type": "Condition", "text": [ "sensory impairment" ], "offsets": [ [ 323, 341 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T26", "type": "Qualifier", "text": [ "lower limbs" ], "offsets": [ [ 345, 356 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T27", "type": "Scope", "text": [ "neuropathy/sensory impairment" ], "offsets": [ [ 312, 341 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T28", "type": "Observation", "text": [ "lack of co-operation" ], "offsets": [ [ 357, 377 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T29", "type": "Condition", "text": [ "inability to use" ], "offsets": [ [ 384, 400 ] ], "normalized": [] }, { "id": "NCT03034733_exc_T30", "type": "Device", "text": [ "tie", "" ], "offsets": [ [ 410, 413 ], [ 444, 444 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03034733_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03034733_exc_T5", "arg2_id": "NCT03034733_exc_T1", "normalized": [] }, { "id": "NCT03034733_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03034733_exc_T9", "arg2_id": "NCT03034733_exc_T8", "normalized": [] }, { "id": "NCT03034733_exc_R3", "type": "Subsumes", "arg1_id": "NCT03034733_exc_T6", "arg2_id": "NCT03034733_exc_T7", "normalized": [] }, { "id": "NCT03034733_exc_R4", "type": "AND", "arg1_id": "NCT03034733_exc_T15", "arg2_id": "NCT03034733_exc_T14", "normalized": [] }, { "id": "NCT03034733_exc_R5", "type": "Has_temporal", "arg1_id": "NCT03034733_exc_T16", "arg2_id": "NCT03034733_exc_T17", "normalized": [] }, { "id": "NCT03034733_exc_R6", "type": "Has_negation", "arg1_id": "NCT03034733_exc_T23", "arg2_id": "NCT03034733_exc_T20", "normalized": [] }, { "id": "NCT03034733_exc_R7", "type": "Has_scope", "arg1_id": "NCT03034733_exc_T19", "arg2_id": "NCT03034733_exc_T23", "normalized": [] }, { "id": "NCT03034733_exc_R8", "type": "Has_temporal", "arg1_id": "NCT03034733_exc_T19", "arg2_id": "NCT03034733_exc_T18", "normalized": [] }, { "id": "NCT03034733_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT03034733_exc_T27", "arg2_id": "NCT03034733_exc_T26", "normalized": [] }, { "id": "NCT03034733_exc_R10", "type": "AND", "arg1_id": "NCT03034733_exc_T29", "arg2_id": "NCT03034733_exc_T30", "normalized": [] }, { "id": "NCT03034733_exc_R11", "type": "Subsumes", "arg1_id": "NCT03034733_exc_T28", "arg2_id": "NCT03034733_exc_T29", "normalized": [] } ]

[ { "id": "NCT03034733_inc_text", "type": "inclusion", "text": [ "primary total knee replacement surgery\nASA (american society of anesthesiologists) class 1-3\n" ], "offsets": [ [ 0, 93 ] ] } ]

[ { "id": "NCT03034733_inc_T1", "type": "Procedure", "text": [ "total knee replacement surgery" ], "offsets": [ [ 8, 38 ] ], "normalized": [] }, { "id": "NCT03034733_inc_T2", "type": "Qualifier", "text": [ "primary" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "NCT03034733_inc_T3", "type": "Measurement", "text": [ "SA", "lass" ], "offsets": [ [ 40, 42 ], [ 84, 88 ] ], "normalized": [] }, { "id": "NCT03034733_inc_T4", "type": "Value", "text": [ "1-3" ], "offsets": [ [ 89, 92 ] ], "normalized": [] }, { "id": "NCT03034733_inc_T5", "type": "Measurement", "text": [ "american society of anesthesiologists" ], "offsets": [ [ 44, 81 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03034733_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03034733_inc_T1", "arg2_id": "NCT03034733_inc_T2", "normalized": [] }, { "id": "NCT03034733_inc_R2", "type": "Has_value", "arg1_id": "NCT03034733_inc_T3", "arg2_id": "NCT03034733_inc_T4", "normalized": [] }, { "id": "NCT03034733_inc_R3", "type": "Subsumes", "arg1_id": "NCT03034733_inc_T3", "arg2_id": "NCT03034733_inc_T5", "normalized": [] } ]

[ { "id": "NCT03034837_exc_text", "type": "exclusion", "text": [ "Can not cooperate with the treatment\nCan not obtain the child's parental consent\n" ], "offsets": [ [ 0, 81 ] ] } ]

[ { "id": "NCT03034837_exc_T1", "type": "Observation", "text": [ "cooperate with the treatment" ], "offsets": [ [ 8, 36 ] ], "normalized": [] }, { "id": "NCT03034837_exc_T2", "type": "Negation", "text": [ "not" ], "offsets": [ [ 4, 7 ] ], "normalized": [] }, { "id": "NCT03034837_exc_T3", "type": "Negation", "text": [ "not" ], "offsets": [ [ 41, 44 ] ], "normalized": [] }, { "id": "NCT03034837_exc_T4", "type": "Observation", "text": [ "child's parental consent" ], "offsets": [ [ 56, 80 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03034837_exc_R1", "type": "Has_negation", "arg1_id": "NCT03034837_exc_T1", "arg2_id": "NCT03034837_exc_T2", "normalized": [] }, { "id": "NCT03034837_exc_R2", "type": "Has_negation", "arg1_id": "NCT03034837_exc_T4", "arg2_id": "NCT03034837_exc_T3", "normalized": [] } ]

[ { "id": "NCT03034837_inc_text", "type": "inclusion", "text": [ "generally healthy grade 1-2 school children\nwith written parental consent\nwith at least 1 sound and fully erupted permanent first molar\n" ], "offsets": [ [ 0, 136 ] ] } ]

[ { "id": "NCT03034837_inc_T1", "type": "Condition", "text": [ "generally healthy" ], "offsets": [ [ 0, 17 ] ], "normalized": [] }, { "id": "NCT03034837_inc_T2", "type": "Observation", "text": [ "grade 1-2 school" ], "offsets": [ [ 18, 34 ] ], "normalized": [] }, { "id": "NCT03034837_inc_T3", "type": "Person", "text": [ "children" ], "offsets": [ [ 35, 43 ] ], "normalized": [] }, { "id": "NCT03034837_inc_T5", "type": "Multiplier", "text": [ "at least 1" ], "offsets": [ [ 79, 89 ] ], "normalized": [] }, { "id": "NCT03034837_inc_T6", "type": "Qualifier", "text": [ "sound" ], "offsets": [ [ 90, 95 ] ], "normalized": [] }, { "id": "NCT03034837_inc_T7", "type": "Qualifier", "text": [ "fully erupted" ], "offsets": [ [ 100, 113 ] ], "normalized": [] }, { "id": "NCT03034837_inc_T8", "type": "Condition", "text": [ "permanent first molar" ], "offsets": [ [ 114, 135 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03034837_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03034837_inc_T8", "arg2_id": "NCT03034837_inc_T7", "normalized": [] }, { "id": "NCT03034837_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03034837_inc_T8", "arg2_id": "NCT03034837_inc_T6", "normalized": [] }, { "id": "NCT03034837_inc_R3", "type": "Has_multiplier", "arg1_id": "NCT03034837_inc_T8", "arg2_id": "NCT03034837_inc_T5", "normalized": [] } ]

[ { "id": "NCT03036462_exc_text", "type": "exclusion", "text": [ "Hypersensitivity to the active substance, to FCM or any of its excipients\nKnown serious hypersensitivity to other parenteral iron products\nAnaemia not attributed to iron deficiency, e.g. other microcytic anaemia\nEvidence of iron overload or disturbances in the utilisation of iron\n" ], "offsets": [ [ 0, 281 ] ] } ]

[ { "id": "NCT03036462_exc_T1", "type": "Condition", "text": [ "Hypersensitivity" ], "offsets": [ [ 0, 16 ] ], "normalized": [] }, { "id": "NCT03036462_exc_T2", "type": "Drug", "text": [ "active substance" ], "offsets": [ [ 24, 40 ] ], "normalized": [] }, { "id": "NCT03036462_exc_T3", "type": "Drug", "text": [ "FCM" ], "offsets": [ [ 45, 48 ] ], "normalized": [] }, { "id": "NCT03036462_exc_T4", "type": "Drug", "text": [ "excipients" ], "offsets": [ [ 63, 73 ] ], "normalized": [] }, { "id": "NCT03036462_exc_T5", "type": "Scope", "text": [ "active substance, to FCM or any of its excipients" ], "offsets": [ [ 24, 73 ] ], "normalized": [] }, { "id": "NCT03036462_exc_T6", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 88, 104 ] ], "normalized": [] }, { "id": "NCT03036462_exc_T7", "type": "Drug", "text": [ "parenteral iron products" ], "offsets": [ [ 114, 138 ] ], "normalized": [] }, { "id": "NCT03036462_exc_T8", "type": "Qualifier", "text": [ "serious" ], "offsets": [ [ 80, 87 ] ], "normalized": [] }, { "id": "NCT03036462_exc_T9", "type": "Condition", "text": [ "Anaemia" ], "offsets": [ [ 139, 146 ] ], "normalized": [] }, { "id": "NCT03036462_exc_T10", "type": "Negation", "text": [ "not" ], "offsets": [ [ 147, 150 ] ], "normalized": [] }, { "id": "NCT03036462_exc_T11", "type": "Drug", "text": [ "iron deficiency" ], "offsets": [ [ 165, 180 ] ], "normalized": [] }, { "id": "NCT03036462_exc_T12", "type": "Mood", "text": [ "attributed to" ], "offsets": [ [ 151, 164 ] ], "normalized": [] }, { "id": "NCT03036462_exc_T13", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 187, 192 ] ], "normalized": [] }, { "id": "NCT03036462_exc_T14", "type": "Condition", "text": [ "microcytic anaemia" ], "offsets": [ [ 193, 211 ] ], "normalized": [] }, { "id": "NCT03036462_exc_T15", "type": "Scope", "text": [ "Anaemia not attributed to iron deficiency" ], "offsets": [ [ 139, 180 ] ], "normalized": [] }, { "id": "NCT03036462_exc_T16", "type": "Scope", "text": [ "other microcytic anaemia" ], "offsets": [ [ 187, 211 ] ], "normalized": [] }, { "id": "NCT03036462_exc_T17", "type": "Condition", "text": [ "iron overload" ], "offsets": [ [ 224, 237 ] ], "normalized": [] }, { "id": "NCT03036462_exc_T18", "type": "Condition", "text": [ "disturbances in the utilisation of iron" ], "offsets": [ [ 241, 280 ] ], "normalized": [] }, { "id": "NCT03036462_exc_T19", "type": "Drug", "text": [ "iron" ], "offsets": [ [ 224, 228 ] ], "normalized": [] }, { "id": "NCT03036462_exc_T20", "type": "Drug", "text": [ "iron" ], "offsets": [ [ 276, 280 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03036462_exc_R1", "type": "Has_scope", "arg1_id": "NCT03036462_exc_T1", "arg2_id": "NCT03036462_exc_T5", "normalized": [] }, { "id": "NCT03036462_exc_R2", "type": "AND", "arg1_id": "NCT03036462_exc_T6", "arg2_id": "NCT03036462_exc_T7", "normalized": [] }, { "id": "NCT03036462_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03036462_exc_T6", "arg2_id": "NCT03036462_exc_T8", "normalized": [] }, { "id": "NCT03036462_exc_R4", "type": "Has_mood", "arg1_id": "NCT03036462_exc_T11", "arg2_id": "NCT03036462_exc_T12", "normalized": [] }, { "id": "NCT03036462_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT03036462_exc_T14", "arg2_id": "NCT03036462_exc_T13", "normalized": [] }, { "id": "NCT03036462_exc_R6", "type": "Has_negation", "arg1_id": "NCT03036462_exc_T11", "arg2_id": "NCT03036462_exc_T10", "normalized": [] }, { "id": "NCT03036462_exc_R7", "type": "AND", "arg1_id": "NCT03036462_exc_T9", "arg2_id": "NCT03036462_exc_T11", "normalized": [] }, { "id": "NCT03036462_exc_R8", "type": "Subsumes", "arg1_id": "NCT03036462_exc_T15", "arg2_id": "NCT03036462_exc_T16", "normalized": [] } ]

[ { "id": "NCT03036462_inc_text", "type": "inclusion", "text": [ "Patients aged at least 18 years\nPatients with chronic heart failure present for at least 12 months\nConfirmed presence of iron deficiency\nSerum haemoglobin of 9.5 to 14.0 g/dL\n" ], "offsets": [ [ 0, 175 ] ] } ]

[ { "id": "NCT03036462_inc_T1", "type": "Person", "text": [ "aged" ], "offsets": [ [ 9, 13 ] ], "normalized": [] }, { "id": "NCT03036462_inc_T2", "type": "Value", "text": [ "at least 18 years" ], "offsets": [ [ 14, 31 ] ], "normalized": [] }, { "id": "NCT03036462_inc_T3", "type": "Condition", "text": [ "chronic heart failure" ], "offsets": [ [ 46, 67 ] ], "normalized": [] }, { "id": "NCT03036462_inc_T4", "type": "Temporal", "text": [ "for at least 12 months" ], "offsets": [ [ 76, 98 ] ], "normalized": [] }, { "id": "NCT03036462_inc_T5", "type": "Drug", "text": [ "iron" ], "offsets": [ [ 121, 125 ] ], "normalized": [] }, { "id": "NCT03036462_inc_T6", "type": "Condition", "text": [ "iron deficiency" ], "offsets": [ [ 121, 136 ] ], "normalized": [] }, { "id": "NCT03036462_inc_T7", "type": "Measurement", "text": [ "Serum haemoglobin" ], "offsets": [ [ 137, 154 ] ], "normalized": [] }, { "id": "NCT03036462_inc_T8", "type": "Value", "text": [ "9.5 to 14.0 g/dL" ], "offsets": [ [ 158, 174 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03036462_inc_R1", "type": "Has_value", "arg1_id": "NCT03036462_inc_T1", "arg2_id": "NCT03036462_inc_T2", "normalized": [] }, { "id": "NCT03036462_inc_R2", "type": "Has_temporal", "arg1_id": "NCT03036462_inc_T3", "arg2_id": "NCT03036462_inc_T4", "normalized": [] }, { "id": "NCT03036462_inc_R4", "type": "Has_value", "arg1_id": "NCT03036462_inc_T7", "arg2_id": "NCT03036462_inc_T8", "normalized": [] } ]

[ { "id": "NCT03040024_exc_text", "type": "exclusion", "text": [ "Emergency surgery\nMonitored Anesthesia Care (i.e., regional anesthesia alone without plans for general anesthesia)\nSurgery involving the eye, eyebrow, forehead, or frontal scalp near the sensor placement\nPoor health literacy\nAllergy, or have experienced any drug reaction to ketamine\nPregnant or lactating\nCurrently in active alcohol withdrawal\n" ], "offsets": [ [ 0, 345 ] ] } ]

[ { "id": "NCT03040024_exc_T1", "type": "Procedure", "text": [ "Emergency surgery" ], "offsets": [ [ 0, 17 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T2", "type": "Visit", "text": [ "Emergency" ], "offsets": [ [ 0, 9 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T3", "type": "Procedure", "text": [ "Monitored Anesthesia Care" ], "offsets": [ [ 18, 43 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T4", "type": "Procedure", "text": [ "regional anesthesia" ], "offsets": [ [ 51, 70 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T5", "type": "Multiplier", "text": [ "alone" ], "offsets": [ [ 71, 76 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T6", "type": "Negation", "text": [ "without" ], "offsets": [ [ 77, 84 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T7", "type": "Mood", "text": [ "plans for" ], "offsets": [ [ 85, 94 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T8", "type": "Procedure", "text": [ "general anesthesia" ], "offsets": [ [ 95, 113 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T9", "type": "Scope", "text": [ "regional anesthesia alone without plans for general anesthesia" ], "offsets": [ [ 51, 113 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T10", "type": "Procedure", "text": [ "Surgery" ], "offsets": [ [ 115, 122 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T11", "type": "Qualifier", "text": [ "eye" ], "offsets": [ [ 137, 140 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T12", "type": "Qualifier", "text": [ "eyebrow" ], "offsets": [ [ 142, 149 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T13", "type": "Qualifier", "text": [ "forehead" ], "offsets": [ [ 151, 159 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T14", "type": "Qualifier", "text": [ "frontal scalp" ], "offsets": [ [ 164, 177 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T16", "type": "Scope", "text": [ "eye, eyebrow, forehead, or frontal scalp" ], "offsets": [ [ 137, 177 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T17", "type": "Observation", "text": [ "Poor health literacy" ], "offsets": [ [ 204, 224 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T18", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 225, 232 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T19", "type": "Condition", "text": [ "drug reaction" ], "offsets": [ [ 258, 271 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T20", "type": "Drug", "text": [ "ketamine" ], "offsets": [ [ 275, 283 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T21", "type": "Scope", "text": [ "Allergy, or have experienced any drug reaction" ], "offsets": [ [ 225, 271 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T22", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 284, 292 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T23", "type": "Condition", "text": [ "lactating" ], "offsets": [ [ 296, 305 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T24", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 319, 325 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T25", "type": "Condition", "text": [ "alcohol withdrawal" ], "offsets": [ [ 326, 344 ] ], "normalized": [] }, { "id": "NCT03040024_exc_T26", "type": "Temporal", "text": [ "Currently" ], "offsets": [ [ 306, 315 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03040024_exc_R2", "type": "Has_mood", "arg1_id": "NCT03040024_exc_T8", "arg2_id": "NCT03040024_exc_T7", "normalized": [] }, { "id": "NCT03040024_exc_R3", "type": "Has_negation", "arg1_id": "NCT03040024_exc_T8", "arg2_id": "NCT03040024_exc_T6", "normalized": [] }, { "id": "NCT03040024_exc_R4", "type": "Has_multiplier", "arg1_id": "NCT03040024_exc_T4", "arg2_id": "NCT03040024_exc_T5", "normalized": [] }, { "id": "NCT03040024_exc_R5", "type": "AND", "arg1_id": "NCT03040024_exc_T4", "arg2_id": "NCT03040024_exc_T8", "normalized": [] }, { "id": "NCT03040024_exc_R6", "type": "Subsumes", "arg1_id": "NCT03040024_exc_T3", "arg2_id": "NCT03040024_exc_T9", "normalized": [] }, { "id": "NCT03040024_exc_R7", "type": "Has_scope", "arg1_id": "NCT03040024_exc_T10", "arg2_id": "NCT03040024_exc_T16", "normalized": [] }, { "id": "NCT03040024_exc_R8", "type": "AND", "arg1_id": "NCT03040024_exc_T21", "arg2_id": "NCT03040024_exc_T20", "normalized": [] }, { "id": "NCT03040024_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT03040024_exc_T25", "arg2_id": "NCT03040024_exc_T24", "normalized": [] }, { "id": "NCT03040024_exc_R10", "type": "Has_temporal", "arg1_id": "NCT03040024_exc_T25", "arg2_id": "NCT03040024_exc_T26", "normalized": [] } ]

[ { "id": "NCT03040024_inc_text", "type": "inclusion", "text": [ "Current diagnosis of otolaryngeal cancer and undergoing surgery with general anesthesia\nCompetent to provide informed consent\n" ], "offsets": [ [ 0, 126 ] ] } ]

[ { "id": "NCT03040024_inc_T1", "type": "Condition", "text": [ "otolaryngeal cancer" ], "offsets": [ [ 21, 40 ] ], "normalized": [] }, { "id": "NCT03040024_inc_T2", "type": "Temporal", "text": [ "undergoing" ], "offsets": [ [ 45, 55 ] ], "normalized": [] }, { "id": "NCT03040024_inc_T3", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 56, 63 ] ], "normalized": [] }, { "id": "NCT03040024_inc_T4", "type": "Procedure", "text": [ "general anesthesia" ], "offsets": [ [ 69, 87 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03040024_inc_R1", "type": "AND", "arg1_id": "NCT03040024_inc_T3", "arg2_id": "NCT03040024_inc_T4", "normalized": [] }, { "id": "NCT03040024_inc_R2", "type": "Has_temporal", "arg1_id": "NCT03040024_inc_T3", "arg2_id": "NCT03040024_inc_T2", "normalized": [] } ]

[ { "id": "NCT03043495_exc_text", "type": "exclusion", "text": [ "Coagulopathies (with prothrombin concentration less than 60% or INR more than 1.5)\nIn-ability to postpone anti-coagulation medications.\nInfection or injury or a lesion at the block site.\nSuspected cervical vertebral column injury necessitating using a neck collar.\nA compromised lung on the contralateral side of the block (Pneumothorax, hemothorax or Pneumonectomy).\nTraumatic vascular injuries or operative interventions (Surgical harvesting) involving arteries of the upper limb on the operative side.\nPatients with communication difficulties.\nHypersensitivity to local anesthetics and/or Dexamethasone.\nPatients on perioperative intravenous (IV) steroids.\n" ], "offsets": [ [ 0, 660 ] ] } ]

[ { "id": "NCT03043495_exc_T1", "type": "Condition", "text": [ "Coagulopathies" ], "offsets": [ [ 0, 14 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T2", "type": "Measurement", "text": [ "prothrombin concentration" ], "offsets": [ [ 21, 46 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T3", "type": "Value", "text": [ "less than 60%" ], "offsets": [ [ 47, 60 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T4", "type": "Value", "text": [ "more than 1.5" ], "offsets": [ [ 68, 81 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T5", "type": "Measurement", "text": [ "INR" ], "offsets": [ [ 64, 67 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T6", "type": "Scope", "text": [ "prothrombin concentration less than 60% or INR more than 1.5" ], "offsets": [ [ 21, 81 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T7", "type": "Drug", "text": [ "anti-coagulation medications" ], "offsets": [ [ 106, 134 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T8", "type": "Mood", "text": [ "In-ability to postpone" ], "offsets": [ [ 83, 105 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T9", "type": "Condition", "text": [ "Infection" ], "offsets": [ [ 136, 145 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T10", "type": "Condition", "text": [ "injury" ], "offsets": [ [ 149, 155 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T11", "type": "Condition", "text": [ "lesion" ], "offsets": [ [ 161, 167 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T12", "type": "Qualifier", "text": [ "at the block site" ], "offsets": [ [ 168, 185 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T13", "type": "Scope", "text": [ "Infection or injury or a lesion" ], "offsets": [ [ 136, 167 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T14", "type": "Condition", "text": [ "cervical vertebral column injury" ], "offsets": [ [ 197, 229 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T15", "type": "Mood", "text": [ "Suspected" ], "offsets": [ [ 187, 196 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T16", "type": "Condition", "text": [ "compromised lung" ], "offsets": [ [ 267, 283 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T17", "type": "Qualifier", "text": [ "contralateral side of the block" ], "offsets": [ [ 291, 322 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T18", "type": "Condition", "text": [ "Pneumothorax" ], "offsets": [ [ 324, 336 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T19", "type": "Condition", "text": [ "hemothorax" ], "offsets": [ [ 338, 348 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T20", "type": "Condition", "text": [ "Pneumonectomy" ], "offsets": [ [ 352, 365 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T21", "type": "Scope", "text": [ "Pneumothorax, hemothorax or Pneumonectomy" ], "offsets": [ [ 324, 365 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T22", "type": "Condition", "text": [ "Traumatic vascular injuries" ], "offsets": [ [ 368, 395 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T23", "type": "Procedure", "text": [ "operative interventions" ], "offsets": [ [ 399, 422 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T24", "type": "Procedure", "text": [ "Surgical harvesting" ], "offsets": [ [ 424, 443 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T25", "type": "Qualifier", "text": [ "arteries of the upper limb on the operative side" ], "offsets": [ [ 455, 503 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T26", "type": "Scope", "text": [ "Traumatic vascular injuries or operative interventions (Surgical harvesting)" ], "offsets": [ [ 368, 444 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T27", "type": "Condition", "text": [ "communication difficulties" ], "offsets": [ [ 519, 545 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T28", "type": "Condition", "text": [ "Hypersensitivity" ], "offsets": [ [ 547, 563 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T29", "type": "Drug", "text": [ "local anesthetics" ], "offsets": [ [ 567, 584 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T30", "type": "Drug", "text": [ "Dexamethasone" ], "offsets": [ [ 592, 605 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T31", "type": "Scope", "text": [ "local anesthetics and/or Dexamethasone" ], "offsets": [ [ 567, 605 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T32", "type": "Temporal", "text": [ "perioperative" ], "offsets": [ [ 619, 632 ] ], "normalized": [] }, { "id": "NCT03043495_exc_T33", "type": "Drug", "text": [ "intravenous (IV) steroids" ], "offsets": [ [ 633, 658 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03043495_exc_R1", "type": "Has_value", "arg1_id": "NCT03043495_exc_T2", "arg2_id": "NCT03043495_exc_T3", "normalized": [] }, { "id": "NCT03043495_exc_R2", "type": "Has_value", "arg1_id": "NCT03043495_exc_T5", "arg2_id": "NCT03043495_exc_T4", "normalized": [] }, { "id": "NCT03043495_exc_R3", "type": "Has_scope", "arg1_id": "NCT03043495_exc_T1", "arg2_id": "NCT03043495_exc_T6", "normalized": [] }, { "id": "NCT03043495_exc_R4", "type": "Has_mood", "arg1_id": "NCT03043495_exc_T7", "arg2_id": "NCT03043495_exc_T8", "normalized": [] }, { "id": "NCT03043495_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT03043495_exc_T13", "arg2_id": "NCT03043495_exc_T12", "normalized": [] }, { "id": "NCT03043495_exc_R6", "type": "Has_mood", "arg1_id": "NCT03043495_exc_T14", "arg2_id": "NCT03043495_exc_T15", "normalized": [] }, { "id": "NCT03043495_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT03043495_exc_T16", "arg2_id": "NCT03043495_exc_T17", "normalized": [] }, { "id": "NCT03043495_exc_R8", "type": "Subsumes", "arg1_id": "NCT03043495_exc_T16", "arg2_id": "NCT03043495_exc_T21", "normalized": [] }, { "id": "NCT03043495_exc_R9", "type": "Subsumes", "arg1_id": "NCT03043495_exc_T23", "arg2_id": "NCT03043495_exc_T24", "normalized": [] }, { "id": "NCT03043495_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT03043495_exc_T26", "arg2_id": "NCT03043495_exc_T25", "normalized": [] }, { "id": "NCT03043495_exc_R11", "type": "Has_scope", "arg1_id": "NCT03043495_exc_T28", "arg2_id": "NCT03043495_exc_T31", "normalized": [] }, { "id": "NCT03043495_exc_R12", "type": "Has_temporal", "arg1_id": "NCT03043495_exc_T33", "arg2_id": "NCT03043495_exc_T32", "normalized": [] } ]

[ { "id": "NCT03043495_inc_text", "type": "inclusion", "text": [ "Patients undergoing surgeries in the upper limb (arm, forearm or hand)\n" ], "offsets": [ [ 0, 71 ] ] } ]

[ { "id": "NCT03043495_inc_T1", "type": "Procedure", "text": [ "surgeries" ], "offsets": [ [ 20, 29 ] ], "normalized": [] }, { "id": "NCT03043495_inc_T2", "type": "Qualifier", "text": [ "upper limb" ], "offsets": [ [ 37, 47 ] ], "normalized": [] }, { "id": "NCT03043495_inc_T3", "type": "Qualifier", "text": [ "arm" ], "offsets": [ [ 49, 52 ] ], "normalized": [] }, { "id": "NCT03043495_inc_T4", "type": "Qualifier", "text": [ "forearm" ], "offsets": [ [ 54, 61 ] ], "normalized": [] }, { "id": "NCT03043495_inc_T5", "type": "Qualifier", "text": [ "hand" ], "offsets": [ [ 65, 69 ] ], "normalized": [] }, { "id": "NCT03043495_inc_T6", "type": "Scope", "text": [ "arm, forearm or hand" ], "offsets": [ [ 49, 69 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03043495_inc_R1", "type": "Subsumes", "arg1_id": "NCT03043495_inc_T2", "arg2_id": "NCT03043495_inc_T6", "normalized": [] }, { "id": "NCT03043495_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03043495_inc_T1", "arg2_id": "NCT03043495_inc_T2", "normalized": [] } ]

[ { "id": "NCT03044093_exc_text", "type": "exclusion", "text": [ "hematology diseases\nclotting factor deficiency\n" ], "offsets": [ [ 0, 47 ] ] } ]

[ { "id": "NCT03044093_exc_T1", "type": "Condition", "text": [ "hematology diseases" ], "offsets": [ [ 0, 19 ] ], "normalized": [] }, { "id": "NCT03044093_exc_T2", "type": "Condition", "text": [ "clotting factor deficiency" ], "offsets": [ [ 20, 46 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "NCT03044093_inc_text", "type": "inclusion", "text": [ "healthy\nno allergy known to these drugs\nsecond trimester abortion\n" ], "offsets": [ [ 0, 66 ] ] } ]

[ { "id": "NCT03044093_inc_T1", "type": "Condition", "text": [ "healthy" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "NCT03044093_inc_T2", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 11, 18 ] ], "normalized": [] }, { "id": "NCT03044093_inc_T3", "type": "Drug", "text": [ "these drugs" ], "offsets": [ [ 28, 39 ] ], "normalized": [] }, { "id": "NCT03044093_inc_T4", "type": "Negation", "text": [ "no" ], "offsets": [ [ 8, 10 ] ], "normalized": [] }, { "id": "NCT03044093_inc_T5", "type": "Qualifier", "text": [ "second trimester" ], "offsets": [ [ 40, 56 ] ], "normalized": [] }, { "id": "NCT03044093_inc_T6", "type": "Condition", "text": [ "abortion" ], "offsets": [ [ 57, 65 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03044093_inc_R1", "type": "AND", "arg1_id": "NCT03044093_inc_T2", "arg2_id": "NCT03044093_inc_T3", "normalized": [] }, { "id": "NCT03044093_inc_R2", "type": "Has_negation", "arg1_id": "NCT03044093_inc_T2", "arg2_id": "NCT03044093_inc_T4", "normalized": [] }, { "id": "NCT03044093_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03044093_inc_T6", "arg2_id": "NCT03044093_inc_T5", "normalized": [] } ]

[ { "id": "NCT03044561_exc_text", "type": "exclusion", "text": [ "(1) Uterine abnormalities (e.g. septate, bicornuate and fibroid uterus, Asherman Syndrome).\nConcurrent use of organic nitrites and nitrates.\nSevere hepatic impairment.\nSevere renal impairment.\nHypotension.\nRecent stroke or heart attack.\n" ], "offsets": [ [ 0, 237 ] ] } ]

[ { "id": "NCT03044561_exc_T1", "type": "Condition", "text": [ "Uterine abnormalities" ], "offsets": [ [ 4, 25 ] ], "normalized": [] }, { "id": "NCT03044561_exc_T2", "type": "Condition", "text": [ "septate", "uterus" ], "offsets": [ [ 32, 39 ], [ 64, 70 ] ], "normalized": [] }, { "id": "NCT03044561_exc_T3", "type": "Condition", "text": [ "bicornuate", "uterus" ], "offsets": [ [ 41, 51 ], [ 64, 70 ] ], "normalized": [] }, { "id": "NCT03044561_exc_T4", "type": "Condition", "text": [ "fibroid uterus" ], "offsets": [ [ 56, 70 ] ], "normalized": [] }, { "id": "NCT03044561_exc_T5", "type": "Condition", "text": [ "Asherman Syndrome" ], "offsets": [ [ 72, 89 ] ], "normalized": [] }, { "id": "NCT03044561_exc_T6", "type": "Scope", "text": [ "septate, bicornuate and fibroid uterus, Asherman Syndrome" ], "offsets": [ [ 32, 89 ] ], "normalized": [] }, { "id": "NCT03044561_exc_T7", "type": "Temporal", "text": [ "Concurrent" ], "offsets": [ [ 92, 102 ] ], "normalized": [] }, { "id": "NCT03044561_exc_T8", "type": "Drug", "text": [ "organic nitrites" ], "offsets": [ [ 110, 126 ] ], "normalized": [] }, { "id": "NCT03044561_exc_T9", "type": "Drug", "text": [ "nitrates" ], "offsets": [ [ 131, 139 ] ], "normalized": [] }, { "id": "NCT03044561_exc_T10", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 141, 147 ] ], "normalized": [] }, { "id": "NCT03044561_exc_T11", "type": "Condition", "text": [ "hepatic impairment" ], "offsets": [ [ 148, 166 ] ], "normalized": [] }, { "id": "NCT03044561_exc_T12", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 168, 174 ] ], "normalized": [] }, { "id": "NCT03044561_exc_T13", "type": "Condition", "text": [ "renal impairment" ], "offsets": [ [ 175, 191 ] ], "normalized": [] }, { "id": "NCT03044561_exc_T14", "type": "Condition", "text": [ "Hypotension" ], "offsets": [ [ 193, 204 ] ], "normalized": [] }, { "id": "NCT03044561_exc_T15", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 213, 219 ] ], "normalized": [] }, { "id": "NCT03044561_exc_T16", "type": "Condition", "text": [ "heart attack" ], "offsets": [ [ 223, 235 ] ], "normalized": [] }, { "id": "NCT03044561_exc_T17", "type": "Temporal", "text": [ "Recent" ], "offsets": [ [ 206, 212 ] ], "normalized": [] }, { "id": "NCT03044561_exc_T18", "type": "Scope", "text": [ "stroke or heart attack" ], "offsets": [ [ 213, 235 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03044561_exc_R1", "type": "Has_scope", "arg1_id": "NCT03044561_exc_T1", "arg2_id": "NCT03044561_exc_T6", "normalized": [] }, { "id": "NCT03044561_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03044561_exc_T8", "arg2_id": "NCT03044561_exc_T7", "normalized": [] }, { "id": "NCT03044561_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03044561_exc_T9", "arg2_id": "NCT03044561_exc_T7", "normalized": [] }, { "id": "NCT03044561_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03044561_exc_T11", "arg2_id": "NCT03044561_exc_T10", "normalized": [] }, { "id": "NCT03044561_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT03044561_exc_T13", "arg2_id": "NCT03044561_exc_T12", "normalized": [] }, { "id": "NCT03044561_exc_R6", "type": "Has_temporal", "arg1_id": "NCT03044561_exc_T18", "arg2_id": "NCT03044561_exc_T17", "normalized": [] } ]

[ { "id": "NCT03044561_inc_text", "type": "inclusion", "text": [ "(1) cases of infertility, older than 20 years of age and not older than 40 years.\n(2) Body mass index (BMI):20-29.\n(3) women have experienced two or more implantation failure attributed to inadequate endometrial development.\n" ], "offsets": [ [ 0, 225 ] ] } ]

[ { "id": "NCT03044561_inc_T1", "type": "Condition", "text": [ "infertility" ], "offsets": [ [ 13, 24 ] ], "normalized": [] }, { "id": "NCT03044561_inc_T2", "type": "Value", "text": [ "older than 20 years" ], "offsets": [ [ 26, 45 ] ], "normalized": [] }, { "id": "NCT03044561_inc_T3", "type": "Person", "text": [ "age" ], "offsets": [ [ 49, 52 ] ], "normalized": [] }, { "id": "NCT03044561_inc_T4", "type": "Value", "text": [ "not older than 40 years" ], "offsets": [ [ 57, 80 ] ], "normalized": [] }, { "id": "NCT03044561_inc_T5", "type": "Measurement", "text": [ "Body mass index" ], "offsets": [ [ 86, 101 ] ], "normalized": [] }, { "id": "NCT03044561_inc_T6", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 103, 106 ] ], "normalized": [] }, { "id": "NCT03044561_inc_T7", "type": "Value", "text": [ "20-29" ], "offsets": [ [ 108, 113 ] ], "normalized": [] }, { "id": "NCT03044561_inc_T8", "type": "Person", "text": [ "women" ], "offsets": [ [ 119, 124 ] ], "normalized": [] }, { "id": "NCT03044561_inc_T9", "type": "Multiplier", "text": [ "two or more" ], "offsets": [ [ 142, 153 ] ], "normalized": [] }, { "id": "NCT03044561_inc_T10", "type": "Procedure", "text": [ "implantation" ], "offsets": [ [ 154, 166 ] ], "normalized": [] }, { "id": "NCT03044561_inc_T11", "type": "Qualifier", "text": [ "failure" ], "offsets": [ [ 167, 174 ] ], "normalized": [] }, { "id": "NCT03044561_inc_T12", "type": "Condition", "text": [ "inadequate endometrial development" ], "offsets": [ [ 189, 223 ] ], "normalized": [] }, { "id": "NCT03044561_inc_T13", "type": "Mood", "text": [ "attributed to" ], "offsets": [ [ 175, 188 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03044561_inc_R1", "type": "Has_value", "arg1_id": "NCT03044561_inc_T3", "arg2_id": "NCT03044561_inc_T2", "normalized": [] }, { "id": "NCT03044561_inc_R2", "type": "Has_value", "arg1_id": "NCT03044561_inc_T3", "arg2_id": "NCT03044561_inc_T4", "normalized": [] }, { "id": "NCT03044561_inc_R3", "type": "Subsumes", "arg1_id": "NCT03044561_inc_T5", "arg2_id": "NCT03044561_inc_T6", "normalized": [] }, { "id": "NCT03044561_inc_R4", "type": "Has_value", "arg1_id": "NCT03044561_inc_T5", "arg2_id": "NCT03044561_inc_T7", "normalized": [] }, { "id": "NCT03044561_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT03044561_inc_T10", "arg2_id": "NCT03044561_inc_T11", "normalized": [] }, { "id": "NCT03044561_inc_R6", "type": "Has_mood", "arg1_id": "NCT03044561_inc_T12", "arg2_id": "NCT03044561_inc_T13", "normalized": [] }, { "id": "NCT03044561_inc_R7", "type": "Has_multiplier", "arg1_id": "NCT03044561_inc_T10", "arg2_id": "NCT03044561_inc_T9", "normalized": [] }, { "id": "NCT03044561_inc_R8", "type": "AND", "arg1_id": "NCT03044561_inc_T10", "arg2_id": "NCT03044561_inc_T12", "normalized": [] } ]

[ { "id": "NCT03045562_exc_text", "type": "exclusion", "text": [ "NA\n\n" ], "offsets": [ [ 0, 4 ] ] } ]

[]

[]

[]

[]

[ { "id": "NCT03045562_inc_text", "type": "inclusion", "text": [ "Informed consent must be obtained prior to any study procedure.\nAge>18 years.\nSubjects of STEMI who underwent primary PCI within the first 12 hours.\n" ], "offsets": [ [ 0, 149 ] ] } ]

[ { "id": "NCT03045562_inc_T2", "type": "Person", "text": [ "Age" ], "offsets": [ [ 64, 67 ] ], "normalized": [] }, { "id": "NCT03045562_inc_T3", "type": "Value", "text": [ ">18 years." ], "offsets": [ [ 67, 77 ] ], "normalized": [] }, { "id": "NCT03045562_inc_T4", "type": "Condition", "text": [ "STEMI" ], "offsets": [ [ 90, 95 ] ], "normalized": [] }, { "id": "NCT03045562_inc_T5", "type": "Procedure", "text": [ "primary PCI" ], "offsets": [ [ 110, 121 ] ], "normalized": [] }, { "id": "NCT03045562_inc_T6", "type": "Temporal", "text": [ "within the first 12 hours." ], "offsets": [ [ 122, 148 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03045562_inc_R1", "type": "Has_value", "arg1_id": "NCT03045562_inc_T2", "arg2_id": "NCT03045562_inc_T3", "normalized": [] }, { "id": "NCT03045562_inc_R2", "type": "AND", "arg1_id": "NCT03045562_inc_T4", "arg2_id": "NCT03045562_inc_T5", "normalized": [] }, { "id": "NCT03045562_inc_R3", "type": "Has_temporal", "arg1_id": "NCT03045562_inc_T5", "arg2_id": "NCT03045562_inc_T6", "normalized": [] } ]

[ { "id": "NCT03046108_exc_text", "type": "exclusion", "text": [ "Contraindication for the use of corticosteroids or local anesthetics\nPresence of inflammatory arthropathy or neuropathy\nSkin lesions in the area\ndiabetes mellitus\nInfiltration or previous surgery in the area\nRefusal to participate in the study\n" ], "offsets": [ [ 0, 244 ] ] } ]

[ { "id": "NCT03046108_exc_T1", "type": "Drug", "text": [ "corticosteroids" ], "offsets": [ [ 32, 47 ] ], "normalized": [] }, { "id": "NCT03046108_exc_T2", "type": "Drug", "text": [ "local anesthetics" ], "offsets": [ [ 51, 68 ] ], "normalized": [] }, { "id": "NCT03046108_exc_T3", "type": "Condition", "text": [ "Contraindication" ], "offsets": [ [ 0, 16 ] ], "normalized": [] }, { "id": "NCT03046108_exc_T4", "type": "Scope", "text": [ "corticosteroids or local anesthetics" ], "offsets": [ [ 32, 68 ] ], "normalized": [] }, { "id": "NCT03046108_exc_T5", "type": "Condition", "text": [ "inflammatory arthropathy" ], "offsets": [ [ 81, 105 ] ], "normalized": [] }, { "id": "NCT03046108_exc_T6", "type": "Condition", "text": [ "europathy", "nflammatory" ], "offsets": [ [ 110, 119 ], [ 82, 93 ] ], "normalized": [] }, { "id": "NCT03046108_exc_T7", "type": "Condition", "text": [ "Skin lesions" ], "offsets": [ [ 120, 132 ] ], "normalized": [] }, { "id": "NCT03046108_exc_T8", "type": "Condition", "text": [ "diabetes mellitus" ], "offsets": [ [ 145, 162 ] ], "normalized": [] }, { "id": "NCT03046108_exc_T9", "type": "Procedure", "text": [ "previous surgery" ], "offsets": [ [ 179, 195 ] ], "normalized": [] }, { "id": "NCT03046108_exc_T10", "type": "Condition", "text": [ "Infiltration" ], "offsets": [ [ 163, 175 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03046108_exc_R1", "type": "Has_scope", "arg1_id": "NCT03046108_exc_T3", "arg2_id": "NCT03046108_exc_T4", "normalized": [] } ]

[ { "id": "NCT03046108_inc_text", "type": "inclusion", "text": [ "Clinical suspicion of Morton neuroma confirmed in ultrasound scan\nSymptoms present more than six months\nThe thickness of the nerve must be at least 2 mm in short axis and at least 5 mm in the longitudinal axis.\n" ], "offsets": [ [ 0, 211 ] ] } ]

[ { "id": "NCT03046108_inc_T1", "type": "Condition", "text": [ "Morton neuroma" ], "offsets": [ [ 22, 36 ] ], "normalized": [] }, { "id": "NCT03046108_inc_T2", "type": "Procedure", "text": [ "ultrasound scan" ], "offsets": [ [ 50, 65 ] ], "normalized": [] }, { "id": "NCT03046108_inc_T3", "type": "Mood", "text": [ "Clinical suspicion" ], "offsets": [ [ 0, 18 ] ], "normalized": [] }, { "id": "NCT03046108_inc_T4", "type": "Temporal", "text": [ "more than six months" ], "offsets": [ [ 83, 103 ] ], "normalized": [] }, { "id": "NCT03046108_inc_T5", "type": "Condition", "text": [ "Symptoms" ], "offsets": [ [ 66, 74 ] ], "normalized": [] }, { "id": "NCT03046108_inc_T6", "type": "Measurement", "text": [ "ickness of the nerve m", " short axis " ], "offsets": [ [ 110, 132 ], [ 155, 167 ] ], "normalized": [] }, { "id": "NCT03046108_inc_T7", "type": "Value", "text": [ "at least 2 mm" ], "offsets": [ [ 139, 152 ] ], "normalized": [] }, { "id": "NCT03046108_inc_T9", "type": "Value", "text": [ "at least 5 mm" ], "offsets": [ [ 171, 184 ] ], "normalized": [] }, { "id": "NCT03046108_inc_T8", "type": "Measurement", "text": [ "ickness of the nerve m", " the longitudinal axis" ], "offsets": [ [ 110, 132 ], [ 187, 209 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03046108_inc_R1", "type": "AND", "arg1_id": "NCT03046108_inc_T1", "arg2_id": "NCT03046108_inc_T2", "normalized": [] }, { "id": "NCT03046108_inc_R2", "type": "Has_mood", "arg1_id": "NCT03046108_inc_T1", "arg2_id": "NCT03046108_inc_T3", "normalized": [] }, { "id": "NCT03046108_inc_R3", "type": "Has_temporal", "arg1_id": "NCT03046108_inc_T5", "arg2_id": "NCT03046108_inc_T4", "normalized": [] }, { "id": "NCT03046108_inc_R4", "type": "Has_value", "arg1_id": "NCT03046108_inc_T6", "arg2_id": "NCT03046108_inc_T7", "normalized": [] }, { "id": "NCT03046108_inc_R5", "type": "Has_value", "arg1_id": "NCT03046108_inc_T8", "arg2_id": "NCT03046108_inc_T9", "normalized": [] } ]

[ { "id": "NCT03047538_exc_text", "type": "exclusion", "text": [ "hypersensitivity to perindopril or to other ACE inhibitors, amlodipine, atorvastatin, dihydropyridines or to or statins\nangioneurotic edema in medical history (hereditary / idiopathic or associated with prior treatment with ACE inhibitors)\nsevere hypotension, shock, including cardiogenic shock\nhemodynamically unstable heart failure\nActive liver disease or unexplained persistent elevations of serum transaminases more than three times normal\nWomen of childbearing age without reliable contraception\npregnancy\nbreastfeeding\nPatients with contraindications listed in the currently valid SP\n" ], "offsets": [ [ 0, 590 ] ] } ]

[ { "id": "NCT03047538_exc_T1", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 0, 16 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T2", "type": "Drug", "text": [ "perindopril" ], "offsets": [ [ 20, 31 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T3", "type": "Drug", "text": [ "ACE inhibitors" ], "offsets": [ [ 44, 58 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T4", "type": "Drug", "text": [ "amlodipine" ], "offsets": [ [ 60, 70 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T5", "type": "Drug", "text": [ "atorvastatin" ], "offsets": [ [ 72, 84 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T6", "type": "Drug", "text": [ "dihydropyridines" ], "offsets": [ [ 86, 102 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T7", "type": "Drug", "text": [ "statins" ], "offsets": [ [ 112, 119 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T8", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 38, 43 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T9", "type": "Scope", "text": [ "perindopril or to other ACE inhibitors, amlodipine, atorvastatin, dihydropyridines or to or statins" ], "offsets": [ [ 20, 119 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T10", "type": "Condition", "text": [ "angioneurotic edema" ], "offsets": [ [ 120, 139 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T11", "type": "Qualifier", "text": [ "idiopathic" ], "offsets": [ [ 173, 183 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T12", "type": "Qualifier", "text": [ "hereditary" ], "offsets": [ [ 160, 170 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T13", "type": "Qualifier", "text": [ "associated" ], "offsets": [ [ 187, 197 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T14", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 209, 218 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T15", "type": "Temporal", "text": [ "prior" ], "offsets": [ [ 203, 208 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T16", "type": "Drug", "text": [ "ACE inhibitors" ], "offsets": [ [ 224, 238 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T17", "type": "Scope", "text": [ "hereditary / idiopathic or associated with prior treatment with ACE inhibitors" ], "offsets": [ [ 160, 238 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T18", "type": "Condition", "text": [ "hypotension" ], "offsets": [ [ 247, 258 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T19", "type": "Condition", "text": [ "shock" ], "offsets": [ [ 260, 265 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T20", "type": "Condition", "text": [ "cardiogenic shock" ], "offsets": [ [ 277, 294 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T21", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 240, 246 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T22", "type": "Scope", "text": [ "hypotension, shock, including cardiogenic shock" ], "offsets": [ [ 247, 294 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T23", "type": "Qualifier", "text": [ "hemodynamically unstable" ], "offsets": [ [ 295, 319 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T24", "type": "Condition", "text": [ "heart failure" ], "offsets": [ [ 320, 333 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T25", "type": "Condition", "text": [ "liver disease" ], "offsets": [ [ 341, 354 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T26", "type": "Measurement", "text": [ "serum transaminases" ], "offsets": [ [ 395, 414 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T27", "type": "Value", "text": [ "more than three times normal" ], "offsets": [ [ 415, 443 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T28", "type": "Value", "text": [ "elevations" ], "offsets": [ [ 381, 391 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T29", "type": "Qualifier", "text": [ "unexplained" ], "offsets": [ [ 358, 369 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T30", "type": "Qualifier", "text": [ "persistent" ], "offsets": [ [ 370, 380 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T31", "type": "Person", "text": [ "Women" ], "offsets": [ [ 444, 449 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T32", "type": "Person", "text": [ "childbearing age" ], "offsets": [ [ 453, 469 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T33", "type": "Qualifier", "text": [ "reliable" ], "offsets": [ [ 478, 486 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T34", "type": "Procedure", "text": [ "contraception" ], "offsets": [ [ 487, 500 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T35", "type": "Negation", "text": [ "without" ], "offsets": [ [ 470, 477 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T36", "type": "Condition", "text": [ "pregnancy" ], "offsets": [ [ 501, 510 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T37", "type": "Observation", "text": [ "breastfeeding" ], "offsets": [ [ 511, 524 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T38", "type": "Condition", "text": [ "contraindications" ], "offsets": [ [ 539, 556 ] ], "normalized": [] }, { "id": "NCT03047538_exc_T39", "type": "Qualifier", "text": [ "listed in the currently valid SP" ], "offsets": [ [ 557, 589 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03047538_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03047538_exc_T3", "arg2_id": "NCT03047538_exc_T8", "normalized": [] }, { "id": "NCT03047538_exc_R2", "type": "Has_scope", "arg1_id": "NCT03047538_exc_T1", "arg2_id": "NCT03047538_exc_T9", "normalized": [] }, { "id": "NCT03047538_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03047538_exc_T14", "arg2_id": "NCT03047538_exc_T15", "normalized": [] }, { "id": "NCT03047538_exc_R4", "type": "AND", "arg1_id": "NCT03047538_exc_T14", "arg2_id": "NCT03047538_exc_T16", "normalized": [] }, { "id": "NCT03047538_exc_R5", "type": "AND", "arg1_id": "NCT03047538_exc_T13", "arg2_id": "NCT03047538_exc_T14", "normalized": [] }, { "id": "NCT03047538_exc_R6", "type": "Has_scope", "arg1_id": "NCT03047538_exc_T10", "arg2_id": "NCT03047538_exc_T17", "normalized": [] }, { "id": "NCT03047538_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT03047538_exc_T22", "arg2_id": "NCT03047538_exc_T21", "normalized": [] }, { "id": "NCT03047538_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT03047538_exc_T24", "arg2_id": "NCT03047538_exc_T23", "normalized": [] }, { "id": "NCT03047538_exc_R9", "type": "Subsumes", "arg1_id": "NCT03047538_exc_T28", "arg2_id": "NCT03047538_exc_T27", "normalized": [] }, { "id": "NCT03047538_exc_R10", "type": "Has_value", "arg1_id": "NCT03047538_exc_T26", "arg2_id": "NCT03047538_exc_T28", "normalized": [] }, { "id": "NCT03047538_exc_R11", "type": "Has_qualifier", "arg1_id": "NCT03047538_exc_T26", "arg2_id": "NCT03047538_exc_T30", "normalized": [] }, { "id": "NCT03047538_exc_R12", "type": "Has_qualifier", "arg1_id": "NCT03047538_exc_T26", "arg2_id": "NCT03047538_exc_T29", "normalized": [] }, { "id": "NCT03047538_exc_R13", "type": "Has_negation", "arg1_id": "NCT03047538_exc_T34", "arg2_id": "NCT03047538_exc_T35", "normalized": [] }, { "id": "NCT03047538_exc_R14", "type": "Has_qualifier", "arg1_id": "NCT03047538_exc_T38", "arg2_id": "NCT03047538_exc_T39", "normalized": [] } ]

[ { "id": "NCT03047538_inc_text", "type": "inclusion", "text": [ "a very high cardiovascular risk and LDL-cholesterol> 1.8 mmol / l\na high cardiovascular risk and LDL-cholesterol> 2.5 mmol / l\nPatient with a high or very high cardiovascular risk treated by lipidlowering therapy with statin\n" ], "offsets": [ [ 0, 225 ] ] } ]

[ { "id": "NCT03047538_inc_T1", "type": "Condition", "text": [ "cardiovascular risk" ], "offsets": [ [ 12, 31 ] ], "normalized": [] }, { "id": "NCT03047538_inc_T2", "type": "Qualifier", "text": [ "very high" ], "offsets": [ [ 2, 11 ] ], "normalized": [] }, { "id": "NCT03047538_inc_T3", "type": "Measurement", "text": [ "LDL-cholesterol" ], "offsets": [ [ 36, 51 ] ], "normalized": [] }, { "id": "NCT03047538_inc_T4", "type": "Value", "text": [ "> 1.8 mmol / l" ], "offsets": [ [ 51, 65 ] ], "normalized": [] }, { "id": "NCT03047538_inc_T5", "type": "Condition", "text": [ "cardiovascular risk" ], "offsets": [ [ 73, 92 ] ], "normalized": [] }, { "id": "NCT03047538_inc_T6", "type": "Qualifier", "text": [ "high" ], "offsets": [ [ 68, 72 ] ], "normalized": [] }, { "id": "NCT03047538_inc_T7", "type": "Measurement", "text": [ "LDL-cholesterol" ], "offsets": [ [ 97, 112 ] ], "normalized": [] }, { "id": "NCT03047538_inc_T8", "type": "Value", "text": [ "> 2.5 mmol / l" ], "offsets": [ [ 112, 126 ] ], "normalized": [] }, { "id": "NCT03047538_inc_T9", "type": "Qualifier", "text": [ "very high" ], "offsets": [ [ 150, 159 ] ], "normalized": [] }, { "id": "NCT03047538_inc_T10", "type": "Qualifier", "text": [ "high" ], "offsets": [ [ 142, 146 ] ], "normalized": [] }, { "id": "NCT03047538_inc_T11", "type": "Condition", "text": [ "cardiovascular risk" ], "offsets": [ [ 160, 179 ] ], "normalized": [] }, { "id": "NCT03047538_inc_T12", "type": "Procedure", "text": [ "lipidlowering therapy" ], "offsets": [ [ 191, 212 ] ], "normalized": [] }, { "id": "NCT03047538_inc_T13", "type": "Drug", "text": [ "stati" ], "offsets": [ [ 218, 223 ] ], "normalized": [] }, { "id": "NCT03047538_inc_T14", "type": "Scope", "text": [ "high or very high" ], "offsets": [ [ 142, 159 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03047538_inc_R1", "type": "Has_value", "arg1_id": "NCT03047538_inc_T3", "arg2_id": "NCT03047538_inc_T4", "normalized": [] }, { "id": "NCT03047538_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03047538_inc_T1", "arg2_id": "NCT03047538_inc_T2", "normalized": [] }, { "id": "NCT03047538_inc_R3", "type": "AND", "arg1_id": "NCT03047538_inc_T1", "arg2_id": "NCT03047538_inc_T3", "normalized": [] }, { "id": "NCT03047538_inc_R4", "type": "Has_value", "arg1_id": "NCT03047538_inc_T7", "arg2_id": "NCT03047538_inc_T8", "normalized": [] }, { "id": "NCT03047538_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT03047538_inc_T5", "arg2_id": "NCT03047538_inc_T6", "normalized": [] }, { "id": "NCT03047538_inc_R6", "type": "AND", "arg1_id": "NCT03047538_inc_T5", "arg2_id": "NCT03047538_inc_T7", "normalized": [] }, { "id": "NCT03047538_inc_R7", "type": "AND", "arg1_id": "NCT03047538_inc_T12", "arg2_id": "NCT03047538_inc_T13", "normalized": [] }, { "id": "NCT03047538_inc_R8", "type": "Has_scope", "arg1_id": "NCT03047538_inc_T11", "arg2_id": "NCT03047538_inc_T14", "normalized": [] }, { "id": "NCT03047538_inc_R9", "type": "AND", "arg1_id": "NCT03047538_inc_T11", "arg2_id": "NCT03047538_inc_T12", "normalized": [] } ]

[ { "id": "NCT03056287_exc_text", "type": "exclusion", "text": [ "1. Unable to ambulate at least 150 feet prior to stroke, or experienced intermittent claudication while walking; \n2. history of congestive heart failure, unstable cardiac arrhythmias, hypertrophic cardiomyopathy, severe aortic stenosis, angina or dyspnea at rest or during ADL's; \n3. History of oxygen dependence; \n4. Preexisting neurological disorders, dementia or previous stroke; \n5. History of major head trauma; \n6. Legal blindness or severe visual impairment; \n7. history of psychosis or other Axis I disorder that is primary; \n8. Life expectancy <1 yr.; \n9. Severe arthritis or other problems that limit passive range of motion; \n10. History of DVT or pulmonary embolism within 6 months; \n11. Uncontrolled diabetes with recent weight loss, diabetic coma, or frequent insulin reactions; \n12. Severe hypertension with systolic >200 mmHg and diastolic >110 mmHg at rest; \n13. attempt of suicide in the last 2 years or at suicidal risk assessed by SCID interview; \n14. Previous or current enrollment in a clinical trial to enhance motor recovery; 15) currently exercising ≥ 2 times per week (≥20 minutes); \n16) Presence of non-MR compatible implants, pregnancy or severe claustrophobia. \n \n" ], "offsets": [ [ 0, 1202 ] ] } ]

[ { "id": "NCT03056287_exc_T16", "type": "Condition", "text": [ "Unable to ambulate at least 150 feet" ], "offsets": [ [ 3, 39 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T17", "type": "Temporal", "text": [ "prior" ], "offsets": [ [ 40, 45 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T18", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 49, 55 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T19", "type": "Reference_point", "text": [ "stroke" ], "offsets": [ [ 49, 55 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T20", "type": "Condition", "text": [ "intermittent claudication" ], "offsets": [ [ 72, 97 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T21", "type": "Qualifier", "text": [ "while walking" ], "offsets": [ [ 98, 111 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T22", "type": "Observation", "text": [ "history" ], "offsets": [ [ 117, 124 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T23", "type": "Condition", "text": [ "congestive heart failure" ], "offsets": [ [ 128, 152 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T24", "type": "Condition", "text": [ "unstable cardiac arrhythmias" ], "offsets": [ [ 154, 182 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T25", "type": "Condition", "text": [ "hypertrophic cardiomyopathy" ], "offsets": [ [ 184, 211 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T26", "type": "Condition", "text": [ "severe aortic stenosis" ], "offsets": [ [ 213, 235 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T27", "type": "Condition", "text": [ "angina" ], "offsets": [ [ 237, 243 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T28", "type": "Condition", "text": [ "dyspnea at rest" ], "offsets": [ [ 247, 262 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T29", "type": "Condition", "text": [ "dyspnea", "during ADL's" ], "offsets": [ [ 247, 254 ], [ 266, 278 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T30", "type": "Scope", "text": [ "congestive heart failure, unstable cardiac arrhythmias, hypertrophic cardiomyopathy, severe aortic stenosis, angina or dyspnea at rest or during ADL's" ], "offsets": [ [ 128, 278 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T31", "type": "Condition", "text": [ "oxygen dependence" ], "offsets": [ [ 295, 312 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T32", "type": "Observation", "text": [ "History" ], "offsets": [ [ 284, 291 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T33", "type": "Condition", "text": [ "neurological disorders" ], "offsets": [ [ 330, 352 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T34", "type": "Condition", "text": [ "dementia" ], "offsets": [ [ 354, 362 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T35", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 375, 381 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T36", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 366, 374 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T37", "type": "Temporal", "text": [ "Preexisting" ], "offsets": [ [ 318, 329 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T38", "type": "Condition", "text": [ "major head trauma" ], "offsets": [ [ 398, 415 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T39", "type": "Observation", "text": [ "History" ], "offsets": [ [ 387, 394 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T40", "type": "Condition", "text": [ "severe visual impairment" ], "offsets": [ [ 440, 464 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T41", "type": "Condition", "text": [ "Legal blindness" ], "offsets": [ [ 421, 436 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T42", "type": "Condition", "text": [ "psychosis" ], "offsets": [ [ 481, 490 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T43", "type": "Condition", "text": [ "Axis I disorder" ], "offsets": [ [ 500, 515 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T44", "type": "Qualifier", "text": [ "primary" ], "offsets": [ [ 524, 531 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T45", "type": "Observation", "text": [ "history" ], "offsets": [ [ 470, 477 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T46", "type": "Observation", "text": [ "Life expectancy" ], "offsets": [ [ 537, 552 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T47", "type": "Value", "text": [ "<1 yr" ], "offsets": [ [ 553, 558 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T48", "type": "Condition", "text": [ "Severe arthritis" ], "offsets": [ [ 565, 581 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T49", "type": "Condition", "text": [ "problems that limit passive range of motion" ], "offsets": [ [ 591, 634 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T51", "type": "Condition", "text": [ "DVT" ], "offsets": [ [ 652, 655 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T52", "type": "Condition", "text": [ "pulmonary embolism" ], "offsets": [ [ 659, 677 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T53", "type": "Temporal", "text": [ "within 6 months" ], "offsets": [ [ 678, 693 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T54", "type": "Observation", "text": [ "History" ], "offsets": [ [ 641, 648 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T55", "type": "Scope", "text": [ "DVT or pulmonary embolism within 6 months" ], "offsets": [ [ 652, 693 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T56", "type": "Condition", "text": [ "diabetes" ], "offsets": [ [ 713, 721 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T57", "type": "Qualifier", "text": [ "Uncontrolled" ], "offsets": [ [ 700, 712 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T58", "type": "Condition", "text": [ "weight loss" ], "offsets": [ [ 734, 745 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T59", "type": "Condition", "text": [ "diabetic coma" ], "offsets": [ [ 747, 760 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T60", "type": "Condition", "text": [ "insulin reactions" ], "offsets": [ [ 774, 791 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T61", "type": "Multiplier", "text": [ "frequent" ], "offsets": [ [ 765, 773 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T62", "type": "Condition", "text": [ "Severe hypertension" ], "offsets": [ [ 798, 817 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T63", "type": "Measurement", "text": [ "systolic" ], "offsets": [ [ 823, 831 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T64", "type": "Value", "text": [ ">200 mmHg" ], "offsets": [ [ 832, 841 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T65", "type": "Measurement", "text": [ "diastolic" ], "offsets": [ [ 846, 855 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T66", "type": "Value", "text": [ ">110 mmHg" ], "offsets": [ [ 856, 865 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T67", "type": "Condition", "text": [ "attempt of suicide" ], "offsets": [ [ 880, 898 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T68", "type": "Temporal", "text": [ "in the last 2 years" ], "offsets": [ [ 899, 918 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T69", "type": "Condition", "text": [ "at suicidal risk" ], "offsets": [ [ 922, 938 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T70", "type": "Procedure", "text": [ "SCID interview" ], "offsets": [ [ 951, 965 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T73", "type": "Device", "text": [ "non-MR compatible implants" ], "offsets": [ [ 1126, 1152 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T74", "type": "Condition", "text": [ "pregnancy" ], "offsets": [ [ 1154, 1163 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T75", "type": "Condition", "text": [ "claustrophobia" ], "offsets": [ [ 1174, 1188 ] ], "normalized": [] }, { "id": "NCT03056287_exc_T76", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 1167, 1173 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03056287_exc_R1", "type": "Has_index", "arg1_id": "NCT03056287_exc_T17", "arg2_id": "NCT03056287_exc_T19", "normalized": [] }, { "id": "NCT03056287_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03056287_exc_T16", "arg2_id": "NCT03056287_exc_T17", "normalized": [] }, { "id": "NCT03056287_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03056287_exc_T20", "arg2_id": "NCT03056287_exc_T21", "normalized": [] }, { "id": "NCT03056287_exc_R4", "type": "Has_scope", "arg1_id": "NCT03056287_exc_T22", "arg2_id": "NCT03056287_exc_T30", "normalized": [] }, { "id": "NCT03056287_exc_R5", "type": "Has_temporal", "arg1_id": "NCT03056287_exc_T31", "arg2_id": "NCT03056287_exc_T32", "normalized": [] }, { "id": "NCT03056287_exc_R6", "type": "Has_temporal", "arg1_id": "NCT03056287_exc_T35", "arg2_id": "NCT03056287_exc_T36", "normalized": [] }, { "id": "NCT03056287_exc_R7", "type": "Has_temporal", "arg1_id": "NCT03056287_exc_T33", "arg2_id": "NCT03056287_exc_T37", "normalized": [] }, { "id": "NCT03056287_exc_R8", "type": "Has_temporal", "arg1_id": "NCT03056287_exc_T34", "arg2_id": "NCT03056287_exc_T37", "normalized": [] }, { "id": "NCT03056287_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03056287_exc_T38", "arg2_id": "NCT03056287_exc_T39", "normalized": [] }, { "id": "NCT03056287_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT03056287_exc_T43", "arg2_id": "NCT03056287_exc_T44", "normalized": [] }, { "id": "NCT03056287_exc_R11", "type": "Has_temporal", "arg1_id": "NCT03056287_exc_T42", "arg2_id": "NCT03056287_exc_T45", "normalized": [] }, { "id": "NCT03056287_exc_R12", "type": "Has_temporal", "arg1_id": "NCT03056287_exc_T43", "arg2_id": "NCT03056287_exc_T45", "normalized": [] }, { "id": "NCT03056287_exc_R13", "type": "Has_value", "arg1_id": "NCT03056287_exc_T46", "arg2_id": "NCT03056287_exc_T47", "normalized": [] }, { "id": "NCT03056287_exc_R14", "type": "Has_temporal", "arg1_id": "NCT03056287_exc_T52", "arg2_id": "NCT03056287_exc_T53", "normalized": [] }, { "id": "NCT03056287_exc_R15", "type": "Has_temporal", "arg1_id": "NCT03056287_exc_T55", "arg2_id": "NCT03056287_exc_T54", "normalized": [] }, { "id": "NCT03056287_exc_R16", "type": "Has_qualifier", "arg1_id": "NCT03056287_exc_T56", "arg2_id": "NCT03056287_exc_T57", "normalized": [] }, { "id": "NCT03056287_exc_R17", "type": "Has_multiplier", "arg1_id": "NCT03056287_exc_T60", "arg2_id": "NCT03056287_exc_T61", "normalized": [] }, { "id": "NCT03056287_exc_R18", "type": "Has_value", "arg1_id": "NCT03056287_exc_T63", "arg2_id": "NCT03056287_exc_T64", "normalized": [] }, { "id": "NCT03056287_exc_R19", "type": "Has_value", "arg1_id": "NCT03056287_exc_T65", "arg2_id": "NCT03056287_exc_T66", "normalized": [] }, { "id": "NCT03056287_exc_R20", "type": "AND", "arg1_id": "NCT03056287_exc_T62", "arg2_id": "NCT03056287_exc_T63", "normalized": [] }, { "id": "NCT03056287_exc_R21", "type": "AND", "arg1_id": "NCT03056287_exc_T62", "arg2_id": "NCT03056287_exc_T65", "normalized": [] }, { "id": "NCT03056287_exc_R22", "type": "AND", "arg1_id": "NCT03056287_exc_T69", "arg2_id": "NCT03056287_exc_T70", "normalized": [] }, { "id": "NCT03056287_exc_R23", "type": "Has_temporal", "arg1_id": "NCT03056287_exc_T67", "arg2_id": "NCT03056287_exc_T68", "normalized": [] }, { "id": "NCT03056287_exc_R24", "type": "Has_qualifier", "arg1_id": "NCT03056287_exc_T75", "arg2_id": "NCT03056287_exc_T76", "normalized": [] } ]

[ { "id": "NCT03056287_inc_text", "type": "inclusion", "text": [ "1) age 50-70 \n2) stroke within the past 6 to 60 months, \n3) major depressive disorder (PHQ-9 > 10) and diagnosed using the Structured Clinical Interview for Depression (SCID) according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), \n4) residual paresis in the lower extremity (Fugl-Meyer LE motor score <34), \n5) ability to walk without assistance and without an AFO on the treadmill ≥ 30 seconds at speeds ranging from 0.2-0.8 m/s, \n6) no antidepressant medications or clinically able to discontinue medications, \n7) HRSD question #9 regarding suicide <2, \n8) provision of informed consent. In addition, all subjects who meet criteria for the training portion must complete an exercise tolerance test and be cleared for participation by the study cardiologist. \n" ], "offsets": [ [ 0, 803 ] ] } ]

[ { "id": "NCT03056287_inc_T1", "type": "Person", "text": [ "age" ], "offsets": [ [ 3, 6 ] ], "normalized": [] }, { "id": "NCT03056287_inc_T2", "type": "Value", "text": [ "50-70" ], "offsets": [ [ 7, 12 ] ], "normalized": [] }, { "id": "NCT03056287_inc_T3", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 17, 23 ] ], "normalized": [] }, { "id": "NCT03056287_inc_T4", "type": "Temporal", "text": [ "within the past 6 to 60 months" ], "offsets": [ [ 24, 54 ] ], "normalized": [] }, { "id": "NCT03056287_inc_T5", "type": "Condition", "text": [ "major depressive disorder" ], "offsets": [ [ 60, 85 ] ], "normalized": [] }, { "id": "NCT03056287_inc_T6", "type": "Measurement", "text": [ "PHQ-9" ], "offsets": [ [ 87, 92 ] ], "normalized": [] }, { "id": "NCT03056287_inc_T7", "type": "Value", "text": [ "> 10" ], "offsets": [ [ 93, 97 ] ], "normalized": [] }, { "id": "NCT03056287_inc_T8", "type": "Procedure", "text": [ "Structured Clinical Interview for Depression (SCID) according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)" ], "offsets": [ [ 123, 270 ] ], "normalized": [] }, { "id": "NCT03056287_inc_T9", "type": "Condition", "text": [ "residual paresis" ], "offsets": [ [ 276, 292 ] ], "normalized": [] }, { "id": "NCT03056287_inc_T10", "type": "Qualifier", "text": [ "lower extremity" ], "offsets": [ [ 300, 315 ] ], "normalized": [] }, { "id": "NCT03056287_inc_T11", "type": "Measurement", "text": [ "Fugl-Meyer LE motor score" ], "offsets": [ [ 317, 342 ] ], "normalized": [] }, { "id": "NCT03056287_inc_T12", "type": "Value", "text": [ "<34" ], "offsets": [ [ 343, 346 ] ], "normalized": [] }, { "id": "NCT03056287_inc_T13", "type": "Condition", "text": [ "ability to walk without assistance" ], "offsets": [ [ 353, 387 ] ], "normalized": [] }, { "id": "NCT03056287_inc_T14", "type": "Measurement", "text": [ "AFO on the treadmill" ], "offsets": [ [ 403, 423 ] ], "normalized": [] }, { "id": "NCT03056287_inc_T15", "type": "Value", "text": [ "≥ 30 seconds" ], "offsets": [ [ 424, 436 ] ], "normalized": [] }, { "id": "NCT03056287_inc_T16", "type": "Negation", "text": [ "without" ], "offsets": [ [ 392, 399 ] ], "normalized": [] }, { "id": "NCT03056287_inc_T17", "type": "Qualifier", "text": [ "speeds" ], "offsets": [ [ 440, 446 ] ], "normalized": [] }, { "id": "NCT03056287_inc_T18", "type": "Value", "text": [ "from 0.2-0.8 m/s" ], "offsets": [ [ 455, 471 ] ], "normalized": [] }, { "id": "NCT03056287_inc_T19", "type": "Drug", "text": [ "antidepressant" ], "offsets": [ [ 480, 494 ] ], "normalized": [] }, { "id": "NCT03056287_inc_T20", "type": "Negation", "text": [ "no" ], "offsets": [ [ 477, 479 ] ], "normalized": [] }, { "id": "NCT03056287_inc_T21", "type": "Condition", "text": [ "clinically able to discontinue medications" ], "offsets": [ [ 510, 552 ] ], "normalized": [] }, { "id": "NCT03056287_inc_T24", "type": "Measurement", "text": [ "HRSD question #9" ], "offsets": [ [ 558, 574 ] ], "normalized": [] }, { "id": "NCT03056287_inc_T25", "type": "Value", "text": [ "<2" ], "offsets": [ [ 593, 595 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03056287_inc_R1", "type": "Has_value", "arg1_id": "NCT03056287_inc_T1", "arg2_id": "NCT03056287_inc_T2", "normalized": [] }, { "id": "NCT03056287_inc_R2", "type": "Has_temporal", "arg1_id": "NCT03056287_inc_T3", "arg2_id": "NCT03056287_inc_T4", "normalized": [] }, { "id": "NCT03056287_inc_R3", "type": "Has_value", "arg1_id": "NCT03056287_inc_T6", "arg2_id": "NCT03056287_inc_T7", "normalized": [] }, { "id": "NCT03056287_inc_R4", "type": "AND", "arg1_id": "NCT03056287_inc_T5", "arg2_id": "NCT03056287_inc_T6", "normalized": [] }, { "id": "NCT03056287_inc_R5", "type": "AND", "arg1_id": "NCT03056287_inc_T5", "arg2_id": "NCT03056287_inc_T8", "normalized": [] }, { "id": "NCT03056287_inc_R6", "type": "Has_qualifier", "arg1_id": "NCT03056287_inc_T9", "arg2_id": "NCT03056287_inc_T10", "normalized": [] }, { "id": "NCT03056287_inc_R7", "type": "Has_value", "arg1_id": "NCT03056287_inc_T11", "arg2_id": "NCT03056287_inc_T12", "normalized": [] }, { "id": "NCT03056287_inc_R8", "type": "AND", "arg1_id": "NCT03056287_inc_T9", "arg2_id": "NCT03056287_inc_T11", "normalized": [] }, { "id": "NCT03056287_inc_R9", "type": "Has_value", "arg1_id": "NCT03056287_inc_T14", "arg2_id": "NCT03056287_inc_T15", "normalized": [] }, { "id": "NCT03056287_inc_R10", "type": "Has_negation", "arg1_id": "NCT03056287_inc_T14", "arg2_id": "NCT03056287_inc_T16", "normalized": [] }, { "id": "NCT03056287_inc_R11", "type": "Has_value", "arg1_id": "NCT03056287_inc_T17", "arg2_id": "NCT03056287_inc_T18", "normalized": [] }, { "id": "NCT03056287_inc_R12", "type": "Has_qualifier", "arg1_id": "NCT03056287_inc_T14", "arg2_id": "NCT03056287_inc_T17", "normalized": [] }, { "id": "NCT03056287_inc_R13", "type": "Has_negation", "arg1_id": "NCT03056287_inc_T19", "arg2_id": "NCT03056287_inc_T20", "normalized": [] }, { "id": "NCT03056287_inc_R14", "type": "Has_value", "arg1_id": "NCT03056287_inc_T24", "arg2_id": "NCT03056287_inc_T25", "normalized": [] } ]

[ { "id": "NCT03056391_exc_text", "type": "exclusion", "text": [ "1. Patient or relatives unable or unwilling to give informed consent \n2. Contraindication or allergy to paracetamol or artesunate therapy \n3. Known cirrhosis, or >6 standard alcoholic drinks/day \n4. Pregnancy \n \n" ], "offsets": [ [ 0, 221 ] ] } ]

[ { "id": "NCT03056391_exc_T7", "type": "Condition", "text": [ "Contraindication" ], "offsets": [ [ 73, 89 ] ], "normalized": [] }, { "id": "NCT03056391_exc_T8", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 93, 100 ] ], "normalized": [] }, { "id": "NCT03056391_exc_T9", "type": "Drug", "text": [ "paracetamol" ], "offsets": [ [ 104, 115 ] ], "normalized": [] }, { "id": "NCT03056391_exc_T10", "type": "Drug", "text": [ "artesunate" ], "offsets": [ [ 119, 129 ] ], "normalized": [] }, { "id": "NCT03056391_exc_T11", "type": "Scope", "text": [ "Contraindication or allergy" ], "offsets": [ [ 73, 100 ] ], "normalized": [] }, { "id": "NCT03056391_exc_T12", "type": "Scope", "text": [ "paracetamol or artesunate" ], "offsets": [ [ 104, 129 ] ], "normalized": [] }, { "id": "NCT03056391_exc_T13", "type": "Condition", "text": [ "cirrhosis" ], "offsets": [ [ 148, 157 ] ], "normalized": [] }, { "id": "NCT03056391_exc_T14", "type": "Condition", "text": [ ">6 standard alcoholic drinks/day" ], "offsets": [ [ 162, 194 ] ], "normalized": [] }, { "id": "NCT03056391_exc_T15", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 199, 208 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03056391_exc_R1", "type": "Has_scope", "arg1_id": "NCT03056391_exc_T11", "arg2_id": "NCT03056391_exc_T12", "normalized": [] } ]

[ { "id": "NCT03056391_inc_text", "type": "inclusion", "text": [ "1. Patient age ≥ 12 years \n2. Presence of P. knowlesi malaria, confirmed by positive blood smear with asexual forms of P. knowlesi. \n3. Temperature >38C on admission or fever during the preceding 48 hours \n4. Enrolled within 18 hours of commencing antimalarial treatment \n5. Written informed consent from patient or attending relative able to and willing to give informed consent. Consent form and information sheets will be translated into Malay and copies provided to the patient. \n" ], "offsets": [ [ 0, 484 ] ] } ]

[ { "id": "NCT03056391_inc_T6", "type": "Person", "text": [ "age" ], "offsets": [ [ 11, 14 ] ], "normalized": [] }, { "id": "NCT03056391_inc_T7", "type": "Value", "text": [ "≥ 12 years" ], "offsets": [ [ 15, 25 ] ], "normalized": [] }, { "id": "NCT03056391_inc_T8", "type": "Condition", "text": [ "P. knowlesi malaria" ], "offsets": [ [ 42, 61 ] ], "normalized": [] }, { "id": "NCT03056391_inc_T9", "type": "Measurement", "text": [ "blood smear" ], "offsets": [ [ 85, 96 ] ], "normalized": [] }, { "id": "NCT03056391_inc_T10", "type": "Value", "text": [ "positive" ], "offsets": [ [ 76, 84 ] ], "normalized": [] }, { "id": "NCT03056391_inc_T11", "type": "Qualifier", "text": [ "with asexual forms of P. knowlesi" ], "offsets": [ [ 97, 130 ] ], "normalized": [] }, { "id": "NCT03056391_inc_T12", "type": "Measurement", "text": [ "Temperature" ], "offsets": [ [ 136, 147 ] ], "normalized": [] }, { "id": "NCT03056391_inc_T13", "type": "Value", "text": [ ">38C" ], "offsets": [ [ 148, 152 ] ], "normalized": [] }, { "id": "NCT03056391_inc_T14", "type": "Temporal", "text": [ "within 18 hours" ], "offsets": [ [ 218, 233 ] ], "normalized": [] }, { "id": "NCT03056391_inc_T15", "type": "Observation", "text": [ "Enrolled" ], "offsets": [ [ 209, 217 ] ], "normalized": [] }, { "id": "NCT03056391_inc_T16", "type": "Reference_point", "text": [ "commencing antimalarial treatment" ], "offsets": [ [ 237, 270 ] ], "normalized": [] }, { "id": "NCT03056391_inc_T17", "type": "Procedure", "text": [ "antimalarial treatment" ], "offsets": [ [ 248, 270 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03056391_inc_R1", "type": "Has_value", "arg1_id": "NCT03056391_inc_T6", "arg2_id": "NCT03056391_inc_T7", "normalized": [] }, { "id": "NCT03056391_inc_R2", "type": "Has_value", "arg1_id": "NCT03056391_inc_T9", "arg2_id": "NCT03056391_inc_T10", "normalized": [] }, { "id": "NCT03056391_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03056391_inc_T10", "arg2_id": "NCT03056391_inc_T11", "normalized": [] }, { "id": "NCT03056391_inc_R4", "type": "AND", "arg1_id": "NCT03056391_inc_T8", "arg2_id": "NCT03056391_inc_T9", "normalized": [] }, { "id": "NCT03056391_inc_R5", "type": "Has_value", "arg1_id": "NCT03056391_inc_T12", "arg2_id": "NCT03056391_inc_T13", "normalized": [] }, { "id": "NCT03056391_inc_R6", "type": "Has_index", "arg1_id": "NCT03056391_inc_T14", "arg2_id": "NCT03056391_inc_T16", "normalized": [] } ]

[ { "id": "NCT03058835_exc_text", "type": "exclusion", "text": [ "Active alcohol or drug use or dependence which may interfere with adherence to study requirements\nHIV-infected at screening or enrollment\nEstimated CrCl < 60 mL/min\nPast participation in an HIV vaccine study\nPositive Hepatitis B surface antigen test\nUnderlying medical condition with survival unlikely during follow-up period\nAny condition that in the opinion of study staff would make participation in the study unsafe or interfere with achieving study objectives\nPregnant or breast feeding\nActively trying to achieve pregnancy\n" ], "offsets": [ [ 0, 529 ] ] } ]

[ { "id": "NCT03058835_exc_T2", "type": "Condition", "text": [ "HIV-infected" ], "offsets": [ [ 98, 110 ] ], "normalized": [] }, { "id": "NCT03058835_exc_T3", "type": "Temporal", "text": [ "at screening" ], "offsets": [ [ 111, 123 ] ], "normalized": [] }, { "id": "NCT03058835_exc_T4", "type": "Temporal", "text": [ "t", "nrollment" ], "offsets": [ [ 112, 113 ], [ 128, 137 ] ], "normalized": [] }, { "id": "NCT03058835_exc_T5", "type": "Scope", "text": [ "at screening or enrollment" ], "offsets": [ [ 111, 137 ] ], "normalized": [] }, { "id": "NCT03058835_exc_T6", "type": "Measurement", "text": [ "Estimated CrCl" ], "offsets": [ [ 138, 152 ] ], "normalized": [] }, { "id": "NCT03058835_exc_T7", "type": "Value", "text": [ "< 60 mL/min" ], "offsets": [ [ 153, 164 ] ], "normalized": [] }, { "id": "NCT03058835_exc_T9", "type": "Value", "text": [ "Positive" ], "offsets": [ [ 208, 216 ] ], "normalized": [] }, { "id": "NCT03058835_exc_T10", "type": "Measurement", "text": [ "Hepatitis B surface antigen test" ], "offsets": [ [ 217, 249 ] ], "normalized": [] }, { "id": "NCT03058835_exc_T11", "type": "Condition", "text": [ "medical condition" ], "offsets": [ [ 261, 278 ] ], "normalized": [] }, { "id": "NCT03058835_exc_T12", "type": "Condition", "text": [ "survival unlikely" ], "offsets": [ [ 284, 301 ] ], "normalized": [] }, { "id": "NCT03058835_exc_T14", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 465, 473 ] ], "normalized": [] }, { "id": "NCT03058835_exc_T15", "type": "Observation", "text": [ "breast feeding" ], "offsets": [ [ 477, 491 ] ], "normalized": [] }, { "id": "NCT03058835_exc_T13", "type": "Condition", "text": [ "condition" ], "offsets": [ [ 330, 339 ] ], "normalized": [] }, { "id": "NCT03058835_exc_T17", "type": "Qualifier", "text": [ "make participation in the study unsafe" ], "offsets": [ [ 381, 419 ] ], "normalized": [] }, { "id": "NCT03058835_exc_T18", "type": "Qualifier", "text": [ "interfere with achieving study objectives" ], "offsets": [ [ 423, 464 ] ], "normalized": [] }, { "id": "NCT03058835_exc_T19", "type": "Scope", "text": [ "make participation in the study unsafe or interfere with achieving study objectives" ], "offsets": [ [ 381, 464 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03058835_exc_R1", "type": "Has_scope", "arg1_id": "NCT03058835_exc_T2", "arg2_id": "NCT03058835_exc_T5", "normalized": [] }, { "id": "NCT03058835_exc_R2", "type": "Has_value", "arg1_id": "NCT03058835_exc_T6", "arg2_id": "NCT03058835_exc_T7", "normalized": [] }, { "id": "NCT03058835_exc_R3", "type": "Has_value", "arg1_id": "NCT03058835_exc_T10", "arg2_id": "NCT03058835_exc_T9", "normalized": [] }, { "id": "NCT03058835_exc_R4", "type": "AND", "arg1_id": "NCT03058835_exc_T11", "arg2_id": "NCT03058835_exc_T12", "normalized": [] }, { "id": "NCT03058835_exc_R5", "type": "Has_scope", "arg1_id": "NCT03058835_exc_T13", "arg2_id": "NCT03058835_exc_T19", "normalized": [] } ]

[ { "id": "NCT03058835_inc_text", "type": "inclusion", "text": [ "18 - 64 years old\nAble to give consent\nunprotected sex (in past 6 months) with 1 or more men of unknown HIV status\nevaluated for an STI within 6 months prior to screening\nsex in last 6 months with an HIV-infected partner\nIDU with report of using previously used or shared needles in past 6 months or has been in a methadone, buprenorphine, or suboxone treatment program in past 6 months or engaging in high-risk sexual behaviors\nindividuals engaging in transactional sex (i.e sex for money, drugs, or housing)\nInfrequently uses condoms during sex with 1 or more partners of unknown HIV status who are known to be at substantial risk of HIV infection (IDU or bisexual male partner)\nCrCl = 60 ml/min\nHIV- uninfected women desiring PrEP\n" ], "offsets": [ [ 0, 734 ] ] } ]

[ { "id": "NCT03058835_inc_T1", "type": "Value", "text": [ "18 - 64 years" ], "offsets": [ [ 0, 13 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T2", "type": "Person", "text": [ "old" ], "offsets": [ [ 14, 17 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T4", "type": "Observation", "text": [ "unprotected sex" ], "offsets": [ [ 39, 54 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T5", "type": "Temporal", "text": [ "in past 6 months" ], "offsets": [ [ 56, 72 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T6", "type": "Multiplier", "text": [ "1 or more" ], "offsets": [ [ 79, 88 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T7", "type": "Person", "text": [ "men of unknown HIV status" ], "offsets": [ [ 89, 114 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T8", "type": "Procedure", "text": [ "evaluated for an STI" ], "offsets": [ [ 115, 135 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T9", "type": "Temporal", "text": [ "within 6 months prior to screening" ], "offsets": [ [ 136, 170 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T10", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 161, 170 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T11", "type": "Observation", "text": [ "sex" ], "offsets": [ [ 171, 174 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T12", "type": "Person", "text": [ "HIV-infected partner" ], "offsets": [ [ 200, 220 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T13", "type": "Temporal", "text": [ "in last 6 months" ], "offsets": [ [ 175, 191 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T15", "type": "Observation", "text": [ "using previously used or shared needles" ], "offsets": [ [ 240, 279 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T16", "type": "Temporal", "text": [ "in past 6 months" ], "offsets": [ [ 280, 296 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T17", "type": "Drug", "text": [ "methadone" ], "offsets": [ [ 314, 323 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T18", "type": "Drug", "text": [ "buprenorphine" ], "offsets": [ [ 325, 338 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T19", "type": "Drug", "text": [ "suboxone" ], "offsets": [ [ 343, 351 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T20", "type": "Procedure", "text": [ "treatment program" ], "offsets": [ [ 352, 369 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T21", "type": "Temporal", "text": [ "in past 6 months" ], "offsets": [ [ 370, 386 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T22", "type": "Observation", "text": [ "engaging in high-risk sexual behaviors" ], "offsets": [ [ 390, 428 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T14", "type": "Person", "text": [ "IDU" ], "offsets": [ [ 221, 224 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T23", "type": "Scope", "text": [ "methadone, buprenorphine, or suboxone" ], "offsets": [ [ 314, 351 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T24", "type": "Observation", "text": [ "transactional sex" ], "offsets": [ [ 453, 470 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T25", "type": "Observation", "text": [ "sex for money" ], "offsets": [ [ 476, 489 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T26", "type": "Observation", "text": [ "r money", " or " ], "offsets": [ [ 482, 489 ], [ 497, 501 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T27", "type": "Observation", "text": [ "r money", "g)\nInfr" ], "offsets": [ [ 482, 489 ], [ 507, 514 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T28", "type": "Scope", "text": [ "sex for money, drugs, or housing" ], "offsets": [ [ 476, 508 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T29", "type": "Observation", "text": [ "Infrequently uses condoms during sex" ], "offsets": [ [ 510, 546 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T30", "type": "Multiplier", "text": [ "1 or more" ], "offsets": [ [ 552, 561 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T31", "type": "Person", "text": [ "partners of unknown HIV status" ], "offsets": [ [ 562, 592 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T32", "type": "Observation", "text": [ "at substantial risk of HIV infection" ], "offsets": [ [ 613, 649 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T33", "type": "Person", "text": [ "IDU" ], "offsets": [ [ 651, 654 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T34", "type": "Person", "text": [ "bisexual male partner" ], "offsets": [ [ 658, 679 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T35", "type": "Measurement", "text": [ "CrCl" ], "offsets": [ [ 681, 685 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T36", "type": "Value", "text": [ "= 60 ml/min" ], "offsets": [ [ 686, 697 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T37", "type": "Condition", "text": [ "HIV- uninfected" ], "offsets": [ [ 698, 713 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T38", "type": "Person", "text": [ "women" ], "offsets": [ [ 714, 719 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T39", "type": "Procedure", "text": [ "PrEP" ], "offsets": [ [ 729, 733 ] ], "normalized": [] }, { "id": "NCT03058835_inc_T40", "type": "Mood", "text": [ "desiring" ], "offsets": [ [ 720, 728 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03058835_inc_R1", "type": "Has_value", "arg1_id": "NCT03058835_inc_T2", "arg2_id": "NCT03058835_inc_T1", "normalized": [] }, { "id": "NCT03058835_inc_R2", "type": "Has_multiplier", "arg1_id": "NCT03058835_inc_T7", "arg2_id": "NCT03058835_inc_T6", "normalized": [] }, { "id": "NCT03058835_inc_R3", "type": "Has_temporal", "arg1_id": "NCT03058835_inc_T4", "arg2_id": "NCT03058835_inc_T5", "normalized": [] }, { "id": "NCT03058835_inc_R4", "type": "AND", "arg1_id": "NCT03058835_inc_T4", "arg2_id": "NCT03058835_inc_T7", "normalized": [] }, { "id": "NCT03058835_inc_R5", "type": "Has_index", "arg1_id": "NCT03058835_inc_T9", "arg2_id": "NCT03058835_inc_T10", "normalized": [] }, { "id": "NCT03058835_inc_R6", "type": "Has_temporal", "arg1_id": "NCT03058835_inc_T8", "arg2_id": "NCT03058835_inc_T9", "normalized": [] }, { "id": "NCT03058835_inc_R7", "type": "AND", "arg1_id": "NCT03058835_inc_T11", "arg2_id": "NCT03058835_inc_T12", "normalized": [] }, { "id": "NCT03058835_inc_R8", "type": "Has_temporal", "arg1_id": "NCT03058835_inc_T11", "arg2_id": "NCT03058835_inc_T13", "normalized": [] }, { "id": "NCT03058835_inc_R10", "type": "Has_temporal", "arg1_id": "NCT03058835_inc_T15", "arg2_id": "NCT03058835_inc_T16", "normalized": [] }, { "id": "NCT03058835_inc_R9", "type": "Has_scope", "arg1_id": "NCT03058835_inc_T20", "arg2_id": "NCT03058835_inc_T23", "normalized": [] }, { "id": "NCT03058835_inc_R11", "type": "Has_temporal", "arg1_id": "NCT03058835_inc_T20", "arg2_id": "NCT03058835_inc_T21", "normalized": [] }, { "id": "NCT03058835_inc_R12", "type": "Subsumes", "arg1_id": "NCT03058835_inc_T24", "arg2_id": "NCT03058835_inc_T28", "normalized": [] }, { "id": "NCT03058835_inc_R14", "type": "Has_multiplier", "arg1_id": "NCT03058835_inc_T31", "arg2_id": "NCT03058835_inc_T30", "normalized": [] }, { "id": "NCT03058835_inc_R15", "type": "AND", "arg1_id": "NCT03058835_inc_T29", "arg2_id": "NCT03058835_inc_T31", "normalized": [] }, { "id": "NCT03058835_inc_R16", "type": "Has_value", "arg1_id": "NCT03058835_inc_T35", "arg2_id": "NCT03058835_inc_T36", "normalized": [] }, { "id": "NCT03058835_inc_R17", "type": "Has_mood", "arg1_id": "NCT03058835_inc_T39", "arg2_id": "NCT03058835_inc_T40", "normalized": [] } ]

[ { "id": "NCT03059069_exc_text", "type": "exclusion", "text": [ "Type 1 diabetes, Secondary diabetes, gestational diabetes\nOngoing dementia treatment or anti-depressive disorder medication\nUncontrolled psychiatric disorder\nBDI = 30 points\nHeavy alcoholics\nUnderlying chronic liver disease (hemochromatosis, liver cell carcinoma, autoimmune liver disease, liver cirrhosis, chronic viral hepatitis)\nAllergy or hypersensitivity to target medication or any of its components\nRenal failure, moderate or severe renal impairment (estimated glomerular filtration rate < 30 mL/min/1.73 m2), or ongoing dialysis\nAbnormal liver function (AST/ALT > x3 upper normal limit)\nHistory of alcohol or drug abuse in the previous 3 months\nPremenopausal women who are nursing or pregnant\nHuman immunodeficiency virus (HIV) or human immunodeficiency virus (AIDS)\nchronic pancreatitis or pancreatic cancer\n" ], "offsets": [ [ 0, 817 ] ] } ]

[ { "id": "NCT03059069_exc_T1", "type": "Condition", "text": [ "Type 1 diabetes" ], "offsets": [ [ 0, 15 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T2", "type": "Condition", "text": [ "Secondary diabetes" ], "offsets": [ [ 17, 35 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T3", "type": "Condition", "text": [ "gestational diabetes" ], "offsets": [ [ 37, 57 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T4", "type": "Condition", "text": [ "dementia" ], "offsets": [ [ 66, 74 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T5", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 75, 84 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T6", "type": "Drug", "text": [ "anti-depressive disorder medication" ], "offsets": [ [ 88, 123 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T7", "type": "Temporal", "text": [ "Ongoing" ], "offsets": [ [ 58, 65 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T8", "type": "Qualifier", "text": [ "Uncontrolled" ], "offsets": [ [ 124, 136 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T9", "type": "Measurement", "text": [ "BDI" ], "offsets": [ [ 158, 161 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T10", "type": "Value", "text": [ "= 30 points" ], "offsets": [ [ 162, 173 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T11", "type": "Qualifier", "text": [ "Heavy" ], "offsets": [ [ 174, 179 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T12", "type": "Condition", "text": [ "alcoholics" ], "offsets": [ [ 180, 190 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T13", "type": "Condition", "text": [ "chronic liver disease" ], "offsets": [ [ 202, 223 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T14", "type": "Condition", "text": [ "hemochromatosis" ], "offsets": [ [ 225, 240 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T15", "type": "Condition", "text": [ "liver cell carcinoma" ], "offsets": [ [ 242, 262 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T16", "type": "Condition", "text": [ "autoimmune liver disease" ], "offsets": [ [ 264, 288 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T17", "type": "Condition", "text": [ "liver cirrhosis" ], "offsets": [ [ 290, 305 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T18", "type": "Condition", "text": [ "chronic viral hepatitis" ], "offsets": [ [ 307, 330 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T19", "type": "Scope", "text": [ "hemochromatosis, liver cell carcinoma, autoimmune liver disease, liver cirrhosis, chronic viral hepatitis" ], "offsets": [ [ 225, 330 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T20", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 332, 339 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T21", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 343, 359 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T22", "type": "Drug", "text": [ "target medication" ], "offsets": [ [ 363, 380 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T23", "type": "Scope", "text": [ "Allergy or hypersensitivity" ], "offsets": [ [ 332, 359 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T24", "type": "Condition", "text": [ "Renal failure" ], "offsets": [ [ 406, 419 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T25", "type": "Qualifier", "text": [ "moderate" ], "offsets": [ [ 421, 429 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T26", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 433, 439 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T27", "type": "Condition", "text": [ "renal impairment" ], "offsets": [ [ 440, 456 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T28", "type": "Scope", "text": [ "moderate or severe" ], "offsets": [ [ 421, 439 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T29", "type": "Measurement", "text": [ "estimated glomerular filtration rate" ], "offsets": [ [ 458, 494 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T30", "type": "Value", "text": [ "< 30 mL/min/1.73 m2" ], "offsets": [ [ 495, 514 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T31", "type": "Temporal", "text": [ "ongoing" ], "offsets": [ [ 520, 527 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T32", "type": "Procedure", "text": [ "dialysis" ], "offsets": [ [ 528, 536 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T33", "type": "Scope", "text": [ "moderate or severe renal impairment" ], "offsets": [ [ 421, 456 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T34", "type": "Scope", "text": [ "estimated glomerular filtration rate < 30 mL/min/1.73 m2" ], "offsets": [ [ 458, 514 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T35", "type": "Measurement", "text": [ "liver function" ], "offsets": [ [ 546, 560 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T36", "type": "Value", "text": [ "Abnormal" ], "offsets": [ [ 537, 545 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T37", "type": "Measurement", "text": [ "AST/ALT" ], "offsets": [ [ 562, 569 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T38", "type": "Value", "text": [ "> x3 upper normal limit" ], "offsets": [ [ 570, 593 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T39", "type": "Scope", "text": [ "Abnormal liver function" ], "offsets": [ [ 537, 560 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T40", "type": "Scope", "text": [ "AST/ALT > x3 upper normal limit" ], "offsets": [ [ 562, 593 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T41", "type": "Condition", "text": [ "drug abuse" ], "offsets": [ [ 617, 627 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T42", "type": "Condition", "text": [ "r drug", "the p" ], "offsets": [ [ 615, 621 ], [ 631, 636 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T43", "type": "Temporal", "text": [ "in the previous 3 months" ], "offsets": [ [ 628, 652 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T44", "type": "Scope", "text": [ "alcohol or drug abuse" ], "offsets": [ [ 606, 627 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T45", "type": "Condition", "text": [ "Premenopausal" ], "offsets": [ [ 653, 666 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T46", "type": "Person", "text": [ "women" ], "offsets": [ [ 667, 672 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T47", "type": "Condition", "text": [ "nursing" ], "offsets": [ [ 681, 688 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T48", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 692, 700 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T49", "type": "Condition", "text": [ "Human immunodeficiency virus (HIV)" ], "offsets": [ [ 701, 735 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T50", "type": "Condition", "text": [ "human immunodeficiency virus (AIDS)" ], "offsets": [ [ 739, 774 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T51", "type": "Condition", "text": [ "chronic pancreatitis" ], "offsets": [ [ 775, 795 ] ], "normalized": [] }, { "id": "NCT03059069_exc_T52", "type": "Condition", "text": [ "pancreatic cancer" ], "offsets": [ [ 799, 816 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03059069_exc_R1", "type": "AND", "arg1_id": "NCT03059069_exc_T5", "arg2_id": "NCT03059069_exc_T4", "normalized": [] }, { "id": "NCT03059069_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03059069_exc_T5", "arg2_id": "NCT03059069_exc_T7", "normalized": [] }, { "id": "NCT03059069_exc_R3", "type": "Has_value", "arg1_id": "NCT03059069_exc_T9", "arg2_id": "NCT03059069_exc_T10", "normalized": [] }, { "id": "NCT03059069_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03059069_exc_T12", "arg2_id": "NCT03059069_exc_T11", "normalized": [] }, { "id": "NCT03059069_exc_R5", "type": "Subsumes", "arg1_id": "NCT03059069_exc_T13", "arg2_id": "NCT03059069_exc_T19", "normalized": [] }, { "id": "NCT03059069_exc_R6", "type": "AND", "arg1_id": "NCT03059069_exc_T23", "arg2_id": "NCT03059069_exc_T22", "normalized": [] }, { "id": "NCT03059069_exc_R7", "type": "Has_scope", "arg1_id": "NCT03059069_exc_T27", "arg2_id": "NCT03059069_exc_T28", "normalized": [] }, { "id": "NCT03059069_exc_R8", "type": "Has_value", "arg1_id": "NCT03059069_exc_T29", "arg2_id": "NCT03059069_exc_T30", "normalized": [] }, { "id": "NCT03059069_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03059069_exc_T32", "arg2_id": "NCT03059069_exc_T31", "normalized": [] }, { "id": "NCT03059069_exc_R10", "type": "Subsumes", "arg1_id": "NCT03059069_exc_T33", "arg2_id": "NCT03059069_exc_T34", "normalized": [] }, { "id": "NCT03059069_exc_R11", "type": "Has_value", "arg1_id": "NCT03059069_exc_T37", "arg2_id": "NCT03059069_exc_T38", "normalized": [] }, { "id": "NCT03059069_exc_R12", "type": "Has_value", "arg1_id": "NCT03059069_exc_T35", "arg2_id": "NCT03059069_exc_T36", "normalized": [] }, { "id": "NCT03059069_exc_R13", "type": "Subsumes", "arg1_id": "NCT03059069_exc_T39", "arg2_id": "NCT03059069_exc_T40", "normalized": [] }, { "id": "NCT03059069_exc_R14", "type": "Has_temporal", "arg1_id": "NCT03059069_exc_T44", "arg2_id": "NCT03059069_exc_T43", "normalized": [] } ]

[ { "id": "NCT03059069_inc_text", "type": "inclusion", "text": [ "Type 2 diabetic patients\nAge = 50\nGlycemic control: HbA1c = 10.0%\n10 = Beck Depression Inventory (BDI) <30 points\nParticipants who can undergo contraception in case of being in childbearing period\nUnderstands the study procedure, alternatives, and risks and voluntarily agrees to participate by giving written informed concent\n" ], "offsets": [ [ 0, 327 ] ] } ]

[ { "id": "NCT03059069_inc_T1", "type": "Condition", "text": [ "Type 2 diabetic" ], "offsets": [ [ 0, 15 ] ], "normalized": [] }, { "id": "NCT03059069_inc_T2", "type": "Person", "text": [ "Age" ], "offsets": [ [ 25, 28 ] ], "normalized": [] }, { "id": "NCT03059069_inc_T3", "type": "Value", "text": [ "= 50" ], "offsets": [ [ 29, 33 ] ], "normalized": [] }, { "id": "NCT03059069_inc_T4", "type": "Measurement", "text": [ "HbA1c" ], "offsets": [ [ 52, 57 ] ], "normalized": [] }, { "id": "NCT03059069_inc_T5", "type": "Value", "text": [ "= 10.0%" ], "offsets": [ [ 58, 65 ] ], "normalized": [] }, { "id": "NCT03059069_inc_T6", "type": "Measurement", "text": [ "Beck Depression Inventory (BDI)" ], "offsets": [ [ 71, 102 ] ], "normalized": [] }, { "id": "NCT03059069_inc_T7", "type": "Value", "text": [ "<30 points" ], "offsets": [ [ 103, 113 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03059069_inc_R1", "type": "Has_value", "arg1_id": "NCT03059069_inc_T2", "arg2_id": "NCT03059069_inc_T3", "normalized": [] }, { "id": "NCT03059069_inc_R2", "type": "Has_value", "arg1_id": "NCT03059069_inc_T4", "arg2_id": "NCT03059069_inc_T5", "normalized": [] }, { "id": "NCT03059069_inc_R3", "type": "Has_value", "arg1_id": "NCT03059069_inc_T6", "arg2_id": "NCT03059069_inc_T7", "normalized": [] } ]

[ { "id": "NCT03062358_exc_text", "type": "exclusion", "text": [ "Is currently participating or has participated in a study with an investigational agent or using an investigational device within 4 weeks of the first dose of study medication \nHas received sorafenib or oxaliplatin-based chemotherapy within 14 days of first dose of study medication \nHas had esophageal or gastric variceal bleeding within the last 6 months \nHas clinically apparent ascites on physical examination \nHas portal vein invasion at the main portal branch (Vp4), inferior vena cava, or cardiac involvement of HCC based on imaging \nHas had clinically diagnosed hepatic encephalopathy in the last 6 months \nHas had a solid organ or hematologic transplant \nHas had prior systemic therapy for HCC in the advanced (incurable) setting other than sorafenib or oxaliplatin-based chemotherapy, prior to start of study medication \nHas an active autoimmune disease that has required systemic treatment in the past 2 years. Replacement therapy is not considered a form of systemic treatment. \nHas a diagnosis of immunodeficiency or is receiving systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of study medication \nHas received locoregional therapy to liver (transcatheter chemoembolization [TACE], transcatheter embolization [TAE], hepatic arterial infusion [HAI], radiation, radioembolization, or ablation) or other site within 4 weeks prior to the first dose of study medication \nHas had major surgery to liver or other site within 4 weeks prior to the first dose of study medication \nHas had a minor surgery ≤7 days prior to the first dose of study medication \nHas not recovered adequately (i.e., Grade ≤1 or baseline) from the toxicity and/or complications from any intervention prior to study start \nHas a diagnosed additional malignancy within 3 years prior to first dose of study medication with the exception of curatively treated basal cell carcinoma of the skin, squamous cell carcinoma of the skin and/or curatively resected in situ cancers \nHas a known history of, or any evidence of, central nervous system (CNS) metastases and/or carcinomatous meningitis \nHas a history of (non-infectious) pneumonitis that required steroids or current pneumonitis \nHas an active infection requiring systemic therapy \nIs pregnant or breast feeding or expecting to conceive or father starting from the first dose of study medication, throughout the study period, and for up to 120 days after the last dose of study medication \nHas received prior immunotherapy with an anti-Programmed Cell Death Receptor 1 (PD-1), Programmed Cell Death Receptor Ligand 1 (anti-PD-L1), or anti- Programmed Cell Death Receptor Ligand 2 (PD-L2) or has previously participated in clinical studies with pembrolizumab \nHas a known history of human immunodeficiency virus (HIV) \nHas untreated active Hepatitis B \nHas hepatitis C in which participants received therapy for HCV <4 weeks prior to receiving pembrolizumab \nHas received a live vaccine within 30 days prior to the first dose of study therapy \n \n" ], "offsets": [ [ 0, 3047 ] ] } ]

[ { "id": "NCT03062358_exc_T2", "type": "Drug", "text": [ "sorafenib" ], "offsets": [ [ 190, 199 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T3", "type": "Drug", "text": [ "oxaliplatin" ], "offsets": [ [ 203, 214 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T4", "type": "Procedure", "text": [ "chemotherapy" ], "offsets": [ [ 221, 233 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T5", "type": "Qualifier", "text": [ "sorafenib or oxaliplatin-based" ], "offsets": [ [ 190, 220 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T6", "type": "Temporal", "text": [ "within 14 days" ], "offsets": [ [ 234, 248 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T7", "type": "Reference_point", "text": [ "first dose of study medication" ], "offsets": [ [ 252, 282 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T8", "type": "Condition", "text": [ "esophageal", "variceal bleeding" ], "offsets": [ [ 292, 302 ], [ 314, 331 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T9", "type": "Condition", "text": [ "gastric variceal bleeding" ], "offsets": [ [ 306, 331 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T10", "type": "Temporal", "text": [ "within the last 6 months" ], "offsets": [ [ 332, 356 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T11", "type": "Scope", "text": [ "esophageal or gastric variceal bleeding" ], "offsets": [ [ 292, 331 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T12", "type": "Condition", "text": [ "ascites" ], "offsets": [ [ 382, 389 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T13", "type": "Condition", "text": [ "portal vein invasion" ], "offsets": [ [ 419, 439 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T14", "type": "Qualifier", "text": [ "main portal branch (Vp4)" ], "offsets": [ [ 447, 471 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T15", "type": "Qualifier", "text": [ "inferior vena cava" ], "offsets": [ [ 473, 491 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T16", "type": "Condition", "text": [ "cardiac involvement" ], "offsets": [ [ 496, 515 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T17", "type": "Condition", "text": [ "HCC" ], "offsets": [ [ 519, 522 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T18", "type": "Procedure", "text": [ "imaging" ], "offsets": [ [ 532, 539 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T19", "type": "Scope", "text": [ "main portal branch (Vp4), inferior vena cava" ], "offsets": [ [ 447, 491 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T20", "type": "Scope", "text": [ "portal vein invasion at the main portal branch (Vp4), inferior vena cava, or cardiac involvement" ], "offsets": [ [ 419, 515 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T21", "type": "Condition", "text": [ "hepatic encephalopathy" ], "offsets": [ [ 570, 592 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T22", "type": "Temporal", "text": [ "in the last 6 months" ], "offsets": [ [ 593, 613 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T23", "type": "Procedure", "text": [ "hematologic transplant" ], "offsets": [ [ 640, 662 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T24", "type": "Procedure", "text": [ "solid organ", "transplant" ], "offsets": [ [ 625, 636 ], [ 652, 662 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T25", "type": "Procedure", "text": [ "systemic therapy" ], "offsets": [ [ 678, 694 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T26", "type": "Condition", "text": [ "HCC" ], "offsets": [ [ 699, 702 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T27", "type": "Drug", "text": [ "sorafenib" ], "offsets": [ [ 750, 759 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T28", "type": "Drug", "text": [ "oxaliplatin" ], "offsets": [ [ 763, 774 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T29", "type": "Procedure", "text": [ "chemotherapy" ], "offsets": [ [ 781, 793 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T30", "type": "Qualifier", "text": [ "sorafenib or oxaliplatin-based" ], "offsets": [ [ 750, 780 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T31", "type": "Temporal", "text": [ "prior" ], "offsets": [ [ 795, 800 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T32", "type": "Reference_point", "text": [ "start of study medication" ], "offsets": [ [ 804, 829 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T33", "type": "Scope", "text": [ "systemic therapy for HCC in the advanced (incurable) setting other than sorafenib or oxaliplatin-based chemotherapy" ], "offsets": [ [ 678, 793 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T34", "type": "Temporal", "text": [ "active" ], "offsets": [ [ 838, 844 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T35", "type": "Condition", "text": [ "autoimmune disease" ], "offsets": [ [ 845, 863 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T36", "type": "Procedure", "text": [ "systemic treatment" ], "offsets": [ [ 882, 900 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T37", "type": "Temporal", "text": [ "in the past 2 years" ], "offsets": [ [ 901, 920 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T39", "type": "Condition", "text": [ "immunodeficiency" ], "offsets": [ [ 1010, 1026 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T40", "type": "Procedure", "text": [ "systemic steroid therapy" ], "offsets": [ [ 1043, 1067 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T41", "type": "Procedure", "text": [ "immunosuppressive therapy" ], "offsets": [ [ 1089, 1114 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T42", "type": "Temporal", "text": [ "within 7 days prior" ], "offsets": [ [ 1115, 1134 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T43", "type": "Reference_point", "text": [ "the first dose of study medication" ], "offsets": [ [ 1138, 1172 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T44", "type": "Scope", "text": [ "systemic steroid therapy or any other form of immunosuppressive therapy" ], "offsets": [ [ 1043, 1114 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T45", "type": "Procedure", "text": [ "locoregional therapy" ], "offsets": [ [ 1187, 1207 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T46", "type": "Procedure", "text": [ "transcatheter chemoembolization [TACE]" ], "offsets": [ [ 1218, 1256 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T47", "type": "Procedure", "text": [ "transcatheter embolization [TAE]" ], "offsets": [ [ 1258, 1290 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T48", "type": "Procedure", "text": [ "hepatic arterial infusion [HAI]" ], "offsets": [ [ 1292, 1323 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T49", "type": "Procedure", "text": [ "radiation" ], "offsets": [ [ 1325, 1334 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T50", "type": "Procedure", "text": [ "radioembolization" ], "offsets": [ [ 1336, 1353 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T51", "type": "Procedure", "text": [ "ablation" ], "offsets": [ [ 1358, 1366 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T52", "type": "Temporal", "text": [ "within 4 weeks prior" ], "offsets": [ [ 1382, 1402 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T53", "type": "Reference_point", "text": [ "first dose of study medication" ], "offsets": [ [ 1410, 1440 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T54", "type": "Qualifier", "text": [ "liver" ], "offsets": [ [ 1211, 1216 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T55", "type": "Qualifier", "text": [ "other site" ], "offsets": [ [ 1371, 1381 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T56", "type": "Scope", "text": [ "transcatheter chemoembolization [TACE], transcatheter embolization [TAE], hepatic arterial infusion [HAI], radiation, radioembolization, or ablation" ], "offsets": [ [ 1218, 1366 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T57", "type": "Procedure", "text": [ "major surgery" ], "offsets": [ [ 1450, 1463 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T58", "type": "Qualifier", "text": [ "liver" ], "offsets": [ [ 1467, 1472 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T59", "type": "Qualifier", "text": [ "other site" ], "offsets": [ [ 1476, 1486 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T60", "type": "Temporal", "text": [ "within 4 weeks prior" ], "offsets": [ [ 1487, 1507 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T61", "type": "Reference_point", "text": [ "first dose of study medication" ], "offsets": [ [ 1515, 1545 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T62", "type": "Procedure", "text": [ "minor surgery" ], "offsets": [ [ 1557, 1570 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T63", "type": "Temporal", "text": [ "≤7 days prior" ], "offsets": [ [ 1571, 1584 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T64", "type": "Reference_point", "text": [ "first dose of study medication" ], "offsets": [ [ 1592, 1622 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T68", "type": "Condition", "text": [ "malignancy" ], "offsets": [ [ 1792, 1802 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T69", "type": "Qualifier", "text": [ "additional" ], "offsets": [ [ 1781, 1791 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T70", "type": "Temporal", "text": [ "within 3 years prior to first dose of study medication" ], "offsets": [ [ 1803, 1857 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T71", "type": "Reference_point", "text": [ "first dose of study medication" ], "offsets": [ [ 1827, 1857 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T72", "type": "Procedure", "text": [ "treated" ], "offsets": [ [ 1891, 1898 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T73", "type": "Qualifier", "text": [ "curatively" ], "offsets": [ [ 1880, 1890 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T75", "type": "Condition", "text": [ "basal cell carcinoma of the skin" ], "offsets": [ [ 1899, 1931 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T76", "type": "Condition", "text": [ "squamous cell carcinoma of the skin" ], "offsets": [ [ 1933, 1968 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T77", "type": "Condition", "text": [ "in situ cancers" ], "offsets": [ [ 1996, 2011 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T78", "type": "Procedure", "text": [ "resected" ], "offsets": [ [ 1987, 1995 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T79", "type": "Qualifier", "text": [ "curatively" ], "offsets": [ [ 1976, 1986 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T80", "type": "Qualifier", "text": [ "curatively treated" ], "offsets": [ [ 1880, 1898 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T81", "type": "Qualifier", "text": [ "curatively resected" ], "offsets": [ [ 1976, 1995 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T82", "type": "Scope", "text": [ "curatively treated basal cell carcinoma of the skin, squamous cell carcinoma of the skin and/or curatively resected in situ cancers" ], "offsets": [ [ 1880, 2011 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T83", "type": "Observation", "text": [ "history" ], "offsets": [ [ 2025, 2032 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T84", "type": "Observation", "text": [ "evidence" ], "offsets": [ [ 2044, 2052 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T85", "type": "Condition", "text": [ "central nervous system (CNS) metastases" ], "offsets": [ [ 2057, 2096 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T86", "type": "Condition", "text": [ "carcinomatous meningitis" ], "offsets": [ [ 2104, 2128 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T87", "type": "Scope", "text": [ "central nervous system (CNS) metastases and/or carcinomatous meningitis" ], "offsets": [ [ 2057, 2128 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T89", "type": "Drug", "text": [ "steroids" ], "offsets": [ [ 2190, 2198 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T90", "type": "Drug", "text": [ "pneumonitis" ], "offsets": [ [ 2210, 2221 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T91", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 2202, 2209 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T92", "type": "Observation", "text": [ "history" ], "offsets": [ [ 2136, 2143 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T93", "type": "Condition", "text": [ "non-infectious) pneumonitis" ], "offsets": [ [ 2148, 2175 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T88", "type": "Procedure", "text": [ "systemic therapy" ], "offsets": [ [ 2257, 2273 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T94", "type": "Temporal", "text": [ "active" ], "offsets": [ [ 2230, 2236 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T95", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 2237, 2246 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T96", "type": "Qualifier", "text": [ "requiring systemic therapy" ], "offsets": [ [ 2247, 2273 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T99", "type": "Procedure", "text": [ "immunotherapy" ], "offsets": [ [ 2502, 2515 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T100", "type": "Drug", "text": [ "anti-Programmed Cell Death Receptor 1 (PD-1)" ], "offsets": [ [ 2524, 2568 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T101", "type": "Drug", "text": [ "Programmed Cell Death Receptor Ligand 1 (anti-PD-L1)" ], "offsets": [ [ 2570, 2622 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T102", "type": "Drug", "text": [ "anti- Programmed Cell Death Receptor Ligand 2 (PD-L2)" ], "offsets": [ [ 2627, 2680 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T104", "type": "Drug", "text": [ "pembrolizumab" ], "offsets": [ [ 2737, 2750 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T105", "type": "Scope", "text": [ "anti-Programmed Cell Death Receptor 1 (PD-1), Programmed Cell Death Receptor Ligand 1 (anti-PD-L1), or anti- Programmed Cell Death Receptor Ligand 2 (PD-L2)" ], "offsets": [ [ 2524, 2680 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T106", "type": "Observation", "text": [ "participated in clinical studies with pembrolizumab" ], "offsets": [ [ 2699, 2750 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T107", "type": "Condition", "text": [ "human immunodeficiency virus (HIV)" ], "offsets": [ [ 2775, 2809 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T108", "type": "Observation", "text": [ "history" ], "offsets": [ [ 2764, 2771 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T109", "type": "Condition", "text": [ "Hepatitis B" ], "offsets": [ [ 2832, 2843 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T110", "type": "Qualifier", "text": [ "untreated" ], "offsets": [ [ 2815, 2824 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T111", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 2825, 2831 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T112", "type": "Condition", "text": [ "hepatitis C" ], "offsets": [ [ 2849, 2860 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T113", "type": "Procedure", "text": [ "therapy for HCV" ], "offsets": [ [ 2892, 2907 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T114", "type": "Temporal", "text": [ "<4 weeks prior" ], "offsets": [ [ 2908, 2922 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T115", "type": "Drug", "text": [ "pembrolizumab" ], "offsets": [ [ 2936, 2949 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T116", "type": "Reference_point", "text": [ "receiving pembrolizumab" ], "offsets": [ [ 2926, 2949 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T117", "type": "Condition", "text": [ "live vaccine" ], "offsets": [ [ 2966, 2978 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T118", "type": "Temporal", "text": [ "30 days prior" ], "offsets": [ [ 2986, 2999 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T119", "type": "Reference_point", "text": [ "first dose of study therapy" ], "offsets": [ [ 3007, 3034 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T120", "type": "Negation", "text": [ "with the exception of" ], "offsets": [ [ 1858, 1879 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T97", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 2278, 2286 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T98", "type": "Observation", "text": [ "breast feeding" ], "offsets": [ [ 2290, 2304 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T121", "type": "Observation", "text": [ "expecting to conceive" ], "offsets": [ [ 2308, 2329 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T122", "type": "Observation", "text": [ "expecting to", "father" ], "offsets": [ [ 2308, 2320 ], [ 2333, 2339 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T123", "type": "Temporal", "text": [ "starting from the first dose of study medication" ], "offsets": [ [ 2340, 2388 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T124", "type": "Reference_point", "text": [ "the first dose of study medication" ], "offsets": [ [ 2354, 2388 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T125", "type": "Temporal", "text": [ "throughout the study period" ], "offsets": [ [ 2390, 2417 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T126", "type": "Reference_point", "text": [ "the study period" ], "offsets": [ [ 2401, 2417 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T127", "type": "Temporal", "text": [ "for up to 120 days after the last dose of study medication" ], "offsets": [ [ 2423, 2481 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T128", "type": "Reference_point", "text": [ "the last dose of study medication" ], "offsets": [ [ 2448, 2481 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T129", "type": "Scope", "text": [ "starting from the first dose of study medication, throughout the study period, and for up to 120 days after the last dose of study medication" ], "offsets": [ [ 2340, 2481 ] ], "normalized": [] }, { "id": "NCT03062358_exc_T130", "type": "Negation", "text": [ "other than" ], "offsets": [ [ 739, 749 ] ], "normalized": [] } ]

[]

[]

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"type": "Has_temporal", "arg1_id": "NCT03062358_exc_T21", "arg2_id": "NCT03062358_exc_T22", "normalized": [] }, { "id": "NCT03062358_exc_R9", "type": "AND", "arg1_id": "NCT03062358_exc_T25", "arg2_id": "NCT03062358_exc_T26", "normalized": [] }, { "id": "NCT03062358_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT03062358_exc_T29", "arg2_id": "NCT03062358_exc_T30", "normalized": [] }, { "id": "NCT03062358_exc_R11", "type": "Has_index", "arg1_id": "NCT03062358_exc_T31", "arg2_id": "NCT03062358_exc_T32", "normalized": [] }, { "id": "NCT03062358_exc_R13", "type": "Has_temporal", "arg1_id": "NCT03062358_exc_T33", "arg2_id": "NCT03062358_exc_T31", "normalized": [] }, { "id": "NCT03062358_exc_R14", "type": "Has_temporal", "arg1_id": "NCT03062358_exc_T35", "arg2_id": "NCT03062358_exc_T34", "normalized": [] }, { "id": "NCT03062358_exc_R15", "type": "AND", "arg1_id": "NCT03062358_exc_T35", "arg2_id": "NCT03062358_exc_T36", "normalized": [] }, { "id": "NCT03062358_exc_R16", "type": "Has_temporal", "arg1_id": "NCT03062358_exc_T35", "arg2_id": "NCT03062358_exc_T37", "normalized": [] }, { "id": "NCT03062358_exc_R17", "type": "Has_index", "arg1_id": "NCT03062358_exc_T42", "arg2_id": "NCT03062358_exc_T43", "normalized": [] }, { "id": "NCT03062358_exc_R18", "type": "Has_temporal", "arg1_id": "NCT03062358_exc_T44", "arg2_id": "NCT03062358_exc_T42", "normalized": [] }, { "id": "NCT03062358_exc_R19", "type": "Has_index", "arg1_id": "NCT03062358_exc_T52", "arg2_id": "NCT03062358_exc_T53", "normalized": [] }, { "id": "NCT03062358_exc_R20", "type": "Has_qualifier", "arg1_id": "NCT03062358_exc_T45", "arg2_id": "NCT03062358_exc_T54", "normalized": [] }, { "id": "NCT03062358_exc_R21", "type": "Subsumes", "arg1_id": "NCT03062358_exc_T45", "arg2_id": "NCT03062358_exc_T56", "normalized": [] }, { "id": "NCT03062358_exc_R22", "type": "Has_temporal", "arg1_id": "NCT03062358_exc_T45", "arg2_id": "NCT03062358_exc_T52", "normalized": [] }, { "id": "NCT03062358_exc_R23", "type": "Has_qualifier", "arg1_id": "NCT03062358_exc_T57", "arg2_id": "NCT03062358_exc_T58", "normalized": [] }, { "id": "NCT03062358_exc_R24", "type": "Has_index", "arg1_id": "NCT03062358_exc_T60", "arg2_id": "NCT03062358_exc_T61", "normalized": [] }, { "id": "NCT03062358_exc_R25", "type": "Has_temporal", "arg1_id": "NCT03062358_exc_T57", "arg2_id": "NCT03062358_exc_T60", "normalized": [] }, { "id": "NCT03062358_exc_R26", "type": "Has_index", "arg1_id": "NCT03062358_exc_T63", "arg2_id": "NCT03062358_exc_T64", "normalized": [] }, { "id": "NCT03062358_exc_R27", "type": "Has_temporal", "arg1_id": "NCT03062358_exc_T62", "arg2_id": "NCT03062358_exc_T63", "normalized": [] }, { "id": "NCT03062358_exc_R28", "type": "Has_qualifier", "arg1_id": "NCT03062358_exc_T68", "arg2_id": "NCT03062358_exc_T69", "normalized": [] }, { "id": "NCT03062358_exc_R29", "type": "Has_qualifier", "arg1_id": "NCT03062358_exc_T72", "arg2_id": "NCT03062358_exc_T73", "normalized": [] }, { "id": "NCT03062358_exc_R30", "type": "Has_qualifier", "arg1_id": "NCT03062358_exc_T78", "arg2_id": "NCT03062358_exc_T79", "normalized": [] }, { "id": "NCT03062358_exc_R31", "type": "Has_qualifier", "arg1_id": "NCT03062358_exc_T75", "arg2_id": "NCT03062358_exc_T80", "normalized": [] }, { "id": "NCT03062358_exc_R32", "type": "Has_qualifier", "arg1_id": "NCT03062358_exc_T77", "arg2_id": "NCT03062358_exc_T81", "normalized": [] }, { "id": "NCT03062358_exc_R34", "type": "Has_index", "arg1_id": "NCT03062358_exc_T70", "arg2_id": "NCT03062358_exc_T71", "normalized": [] }, { "id": "NCT03062358_exc_R35", "type": "Has_temporal", "arg1_id": "NCT03062358_exc_T68", "arg2_id": "NCT03062358_exc_T70", "normalized": [] }, { "id": "NCT03062358_exc_R37", "type": "Has_temporal", "arg1_id": "NCT03062358_exc_T87", "arg2_id": "NCT03062358_exc_T83", "normalized": [] }, { "id": "NCT03062358_exc_R38", "type": "AND", "arg1_id": "NCT03062358_exc_T93", "arg2_id": "NCT03062358_exc_T89", "normalized": [] }, { "id": "NCT03062358_exc_R39", "type": "Has_temporal", "arg1_id": "NCT03062358_exc_T90", "arg2_id": "NCT03062358_exc_T91", "normalized": [] }, { "id": "NCT03062358_exc_R40", "type": "Has_temporal", "arg1_id": "NCT03062358_exc_T93", "arg2_id": "NCT03062358_exc_T92", "normalized": [] }, { "id": "NCT03062358_exc_R41", "type": "Has_qualifier", "arg1_id": "NCT03062358_exc_T95", "arg2_id": "NCT03062358_exc_T96", "normalized": [] }, { "id": "NCT03062358_exc_R42", "type": "Has_temporal", "arg1_id": "NCT03062358_exc_T95", "arg2_id": "NCT03062358_exc_T94", "normalized": [] }, { "id": "NCT03062358_exc_R43", "type": "Has_scope", "arg1_id": "NCT03062358_exc_T99", "arg2_id": "NCT03062358_exc_T105", "normalized": [] }, { "id": "NCT03062358_exc_R44", "type": "Has_temporal", "arg1_id": "NCT03062358_exc_T107", "arg2_id": "NCT03062358_exc_T108", "normalized": [] }, { "id": "NCT03062358_exc_R45", "type": "Has_qualifier", "arg1_id": "NCT03062358_exc_T109", "arg2_id": "NCT03062358_exc_T111", "normalized": [] }, { "id": "NCT03062358_exc_R46", "type": "Has_qualifier", "arg1_id": "NCT03062358_exc_T109", "arg2_id": "NCT03062358_exc_T110", "normalized": [] }, { "id": "NCT03062358_exc_R47", "type": "Has_index", "arg1_id": "NCT03062358_exc_T114", "arg2_id": "NCT03062358_exc_T116", "normalized": [] }, { "id": "NCT03062358_exc_R48", "type": "Has_temporal", "arg1_id": "NCT03062358_exc_T113", "arg2_id": "NCT03062358_exc_T114", "normalized": [] }, { "id": "NCT03062358_exc_R49", "type": "AND", "arg1_id": "NCT03062358_exc_T112", "arg2_id": "NCT03062358_exc_T113", "normalized": [] }, { "id": "NCT03062358_exc_R50", "type": "Has_index", "arg1_id": "NCT03062358_exc_T118", "arg2_id": "NCT03062358_exc_T119", "normalized": [] }, { "id": "NCT03062358_exc_R51", "type": "Has_temporal", "arg1_id": "NCT03062358_exc_T117", "arg2_id": "NCT03062358_exc_T118", "normalized": [] }, { "id": "NCT03062358_exc_R33", "type": "Has_negation", "arg1_id": "NCT03062358_exc_T82", "arg2_id": "NCT03062358_exc_T120", "normalized": [] }, { "id": "NCT03062358_exc_R52", "type": "Has_scope", "arg1_id": "NCT03062358_exc_T68", "arg2_id": "NCT03062358_exc_T82", "normalized": [] }, { "id": "NCT03062358_exc_R53", "type": "Has_index", "arg1_id": "NCT03062358_exc_T123", "arg2_id": "NCT03062358_exc_T124", "normalized": [] }, { "id": "NCT03062358_exc_R55", "type": "Has_index", "arg1_id": "NCT03062358_exc_T125", "arg2_id": "NCT03062358_exc_T126", "normalized": [] }, { "id": "NCT03062358_exc_R56", "type": "Has_index", "arg1_id": "NCT03062358_exc_T127", "arg2_id": "NCT03062358_exc_T128", "normalized": [] }, { "id": "NCT03062358_exc_R54", "type": "Has_scope", "arg1_id": "NCT03062358_exc_T122", "arg2_id": "NCT03062358_exc_T129", "normalized": [] }, { "id": "NCT03062358_exc_R12", "type": "Has_negation", "arg1_id": "NCT03062358_exc_T29", "arg2_id": "NCT03062358_exc_T130", "normalized": [] }, { "id": "NCT03062358_exc_R57", "type": "AND", "arg1_id": "NCT03062358_exc_T25", "arg2_id": "NCT03062358_exc_T29", "normalized": [] } ]

[ { "id": "NCT03062358_inc_text", "type": "inclusion", "text": [ "Has a HCC diagnosis confirmed by radiology, histology, or cytology (fibrolamellar, and mixed hepatocellular/cholangiocarcinoma subtypes are not eligible) \nHas Barcelona Clinic Liver Cancer (BCLC) Stage C disease or BCLC Stage B disease not amenable to locoregional therapy or refractory to locoregional therapy and not amenable to a curative treatment approach \nHas a Child-Pugh A liver score within 7 days prior to first dose of study medication \nHas a life expectancy of >3 months \nHas at least one measurable lesion based on RECIST version 1.1 as determined by investigator \nHas Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 performed within 7 days prior to receiving the first dose of study medication \nHas documented objective radiographic progression during or after treatment with sorafenib or oxaliplatin-based chemotherapy, or else intolerance to sorafenib or oxaliplatin-based chemotherapy \nFemale participants of childbearing potential must have a negative urine or serum pregnancy test within 72 hours prior to receiving the first dose of study therapy \nFemale and male participants of reproductive potential must agree to use adequate contraception starting from the first dose of study medication, throughout the study period, and for up to 120 days after the last dose of study medication \n" ], "offsets": [ [ 0, 1330 ] ] } ]

[ { "id": "NCT03062358_inc_T1", "type": "Condition", "text": [ "HCC" ], "offsets": [ [ 6, 9 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T2", "type": "Procedure", "text": [ "radiology" ], "offsets": [ [ 33, 42 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T3", "type": "Procedure", "text": [ "histology" ], "offsets": [ [ 44, 53 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T4", "type": "Procedure", "text": [ "cytology" ], "offsets": [ [ 58, 66 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T5", "type": "Scope", "text": [ "radiology, histology, or cytology" ], "offsets": [ [ 33, 66 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T6", "type": "Condition", "text": [ "subtype", "fibrolamellar" ], "offsets": [ [ 127, 134 ], [ 68, 81 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T7", "type": "Condition", "text": [ "mixed hepatocellular/cholangiocarcinoma subtype" ], "offsets": [ [ 87, 134 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T8", "type": "Negation", "text": [ "not eligible" ], "offsets": [ [ 140, 152 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T9", "type": "Scope", "text": [ "fibrolamellar, and mixed hepatocellular/cholangiocarcinoma subtypes are not eligible" ], "offsets": [ [ 68, 152 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T10", "type": "Measurement", "text": [ "Barcelona Clinic Liver Cancer (BCLC)" ], "offsets": [ [ 159, 195 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T11", "type": "Value", "text": [ "Stage C" ], "offsets": [ [ 196, 203 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T12", "type": "Condition", "text": [ "disease" ], "offsets": [ [ 204, 211 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T14", "type": "Measurement", "text": [ "BCLC" ], "offsets": [ [ 215, 219 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T15", "type": "Value", "text": [ "Stage B" ], "offsets": [ [ 220, 227 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T16", "type": "Qualifier", "text": [ "amenable to locoregional therapy" ], "offsets": [ [ 240, 272 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T17", "type": "Qualifier", "text": [ "refractory to locoregional therapy" ], "offsets": [ [ 276, 310 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T18", "type": "Qualifier", "text": [ "amenable to a curative treatment approach" ], "offsets": [ [ 319, 360 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T19", "type": "Negation", "text": [ "not" ], "offsets": [ [ 236, 239 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T20", "type": "Negation", "text": [ "not" ], "offsets": [ [ 315, 318 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T21", "type": "Scope", "text": [ "amenable to locoregional therapy or refractory to locoregional therapy" ], "offsets": [ [ 240, 310 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T22", "type": "Condition", "text": [ "disease" ], "offsets": [ [ 228, 235 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T24", "type": "Measurement", "text": [ "Child-Pugh", "liver score" ], "offsets": [ [ 368, 378 ], [ 381, 392 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T25", "type": "Value", "text": [ "A" ], "offsets": [ [ 379, 380 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T26", "type": "Temporal", "text": [ "within 7 days prior" ], "offsets": [ [ 393, 412 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T27", "type": "Reference_point", "text": [ "first dose of study medication" ], "offsets": [ [ 416, 446 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T28", "type": "Observation", "text": [ "life expectancy" ], "offsets": [ [ 454, 469 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T29", "type": "Value", "text": [ ">3 months" ], "offsets": [ [ 473, 482 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T30", "type": "Multiplier", "text": [ "at least one" ], "offsets": [ [ 488, 500 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T32", "type": "Condition", "text": [ "lesion" ], "offsets": [ [ 512, 518 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T31", "type": "Measurement", "text": [ "RECIST version 1.1" ], "offsets": [ [ 528, 546 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T33", "type": "Value", "text": [ "measurable" ], "offsets": [ [ 501, 511 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T34", "type": "Measurement", "text": [ "Eastern Cooperative Oncology Group (ECOG) performance status" ], "offsets": [ [ 582, 642 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T35", "type": "Value", "text": [ "0 or 1" ], "offsets": [ [ 646, 652 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T36", "type": "Temporal", "text": [ "within 7 days prior" ], "offsets": [ [ 663, 682 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T37", "type": "Reference_point", "text": [ "receiving the first dose of study medication" ], "offsets": [ [ 686, 730 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T38", "type": "Procedure", "text": [ "radiographic" ], "offsets": [ [ 757, 769 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T39", "type": "Observation", "text": [ "objective", "progression" ], "offsets": [ [ 747, 756 ], [ 770, 781 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T40", "type": "Temporal", "text": [ "during or after" ], "offsets": [ [ 782, 797 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T41", "type": "Reference_point", "text": [ "treatment with sorafenib or oxaliplatin-based chemotherapy" ], "offsets": [ [ 798, 856 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T42", "type": "Drug", "text": [ "sorafenib" ], "offsets": [ [ 813, 822 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T43", "type": "Drug", "text": [ "oxaliplatin" ], "offsets": [ [ 826, 837 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T44", "type": "Qualifier", "text": [ "sorafenib or oxaliplatin-based" ], "offsets": [ [ 813, 843 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T45", "type": "Procedure", "text": [ "chemotherapy" ], "offsets": [ [ 844, 856 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T46", "type": "Condition", "text": [ "intolerance" ], "offsets": [ [ 866, 877 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T47", "type": "Drug", "text": [ "sorafenib" ], "offsets": [ [ 881, 890 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T48", "type": "Drug", "text": [ "oxaliplatin" ], "offsets": [ [ 894, 905 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T49", "type": "Qualifier", "text": [ "sorafenib or oxaliplatin-based" ], "offsets": [ [ 881, 911 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T50", "type": "Procedure", "text": [ "chemotherapy" ], "offsets": [ [ 912, 924 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T51", "type": "Person", "text": [ "Female" ], "offsets": [ [ 926, 932 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T52", "type": "Condition", "text": [ "childbearing potential" ], "offsets": [ [ 949, 971 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T53", "type": "Scope", "text": [ "Female participants of childbearing potential" ], "offsets": [ [ 926, 971 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T54", "type": "Measurement", "text": [ "pregnancy test", "urine" ], "offsets": [ [ 1008, 1022 ], [ 993, 998 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T55", "type": "Measurement", "text": [ "serum pregnancy test" ], "offsets": [ [ 1002, 1022 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T56", "type": "Temporal", "text": [ "within 72 hours prior" ], "offsets": [ [ 1023, 1044 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T57", "type": "Scope", "text": [ "urine or serum pregnancy test" ], "offsets": [ [ 993, 1022 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T58", "type": "Value", "text": [ "negative" ], "offsets": [ [ 984, 992 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T59", "type": "Reference_point", "text": [ "receiving the first dose of study therapy" ], "offsets": [ [ 1048, 1089 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T60", "type": "Procedure", "text": [ "adequate contraception" ], "offsets": [ [ 1164, 1186 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T61", "type": "Person", "text": [ "male" ], "offsets": [ [ 1102, 1106 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T62", "type": "Person", "text": [ "Female" ], "offsets": [ [ 1091, 1097 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T64", "type": "Condition", "text": [ "reproductive potential" ], "offsets": [ [ 1123, 1145 ] ], "normalized": [] }, { "id": "NCT03062358_inc_T65", "type": "Scope", "text": [ "Female and male participants of reproductive potential" ], "offsets": [ [ 1091, 1145 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03062358_inc_R1", "type": "Has_scope", "arg1_id": "NCT03062358_inc_T1", "arg2_id": "NCT03062358_inc_T5", "normalized": [] }, { "id": "NCT03062358_inc_R2", "type": "Has_negation", "arg1_id": "NCT03062358_inc_T7", "arg2_id": "NCT03062358_inc_T8", "normalized": [] }, { "id": "NCT03062358_inc_R3", "type": "Has_negation", "arg1_id": "NCT03062358_inc_T6", "arg2_id": "NCT03062358_inc_T8", "normalized": [] }, { "id": "NCT03062358_inc_R4", "type": "Has_scope", "arg1_id": "NCT03062358_inc_T1", "arg2_id": "NCT03062358_inc_T9", "normalized": [] }, { "id": "NCT03062358_inc_R5", "type": "Has_value", "arg1_id": "NCT03062358_inc_T10", "arg2_id": "NCT03062358_inc_T11", "normalized": [] }, { "id": "NCT03062358_inc_R6", "type": "Has_value", "arg1_id": "NCT03062358_inc_T14", "arg2_id": "NCT03062358_inc_T15", "normalized": [] }, { "id": "NCT03062358_inc_R7", "type": "Has_negation", "arg1_id": "NCT03062358_inc_T18", "arg2_id": "NCT03062358_inc_T20", "normalized": [] }, { "id": "NCT03062358_inc_R8", "type": "AND", "arg1_id": "NCT03062358_inc_T12", "arg2_id": "NCT03062358_inc_T10", "normalized": [] }, { "id": "NCT03062358_inc_R9", "type": "AND", "arg1_id": "NCT03062358_inc_T22", "arg2_id": "NCT03062358_inc_T14", "normalized": [] }, { "id": "NCT03062358_inc_R10", "type": "Has_scope", "arg1_id": "NCT03062358_inc_T22", "arg2_id": "NCT03062358_inc_T21", "normalized": [] }, { "id": "NCT03062358_inc_R11", "type": "Has_qualifier", "arg1_id": "NCT03062358_inc_T22", "arg2_id": "NCT03062358_inc_T18", "normalized": [] }, { "id": "NCT03062358_inc_R12", "type": "Has_value", "arg1_id": "NCT03062358_inc_T24", "arg2_id": "NCT03062358_inc_T25", "normalized": [] }, { "id": "NCT03062358_inc_R13", "type": "Has_index", "arg1_id": "NCT03062358_inc_T26", "arg2_id": "NCT03062358_inc_T27", "normalized": [] }, { "id": "NCT03062358_inc_R14", "type": "Has_temporal", "arg1_id": "NCT03062358_inc_T24", "arg2_id": "NCT03062358_inc_T26", "normalized": [] }, { "id": "NCT03062358_inc_R15", "type": "Has_value", "arg1_id": "NCT03062358_inc_T28", "arg2_id": "NCT03062358_inc_T29", "normalized": [] }, { "id": "NCT03062358_inc_R16", "type": "Has_value", "arg1_id": "NCT03062358_inc_T31", "arg2_id": "NCT03062358_inc_T33", "normalized": [] }, { "id": "NCT03062358_inc_R17", "type": "AND", "arg1_id": "NCT03062358_inc_T32", "arg2_id": "NCT03062358_inc_T31", "normalized": [] }, { "id": "NCT03062358_inc_R18", "type": "Has_multiplier", "arg1_id": "NCT03062358_inc_T32", "arg2_id": "NCT03062358_inc_T30", "normalized": [] }, { "id": "NCT03062358_inc_R19", "type": "Has_value", "arg1_id": "NCT03062358_inc_T34", "arg2_id": "NCT03062358_inc_T35", "normalized": [] }, { "id": "NCT03062358_inc_R20", "type": "Has_index", "arg1_id": "NCT03062358_inc_T36", "arg2_id": "NCT03062358_inc_T37", "normalized": [] }, { "id": "NCT03062358_inc_R21", "type": "Has_temporal", "arg1_id": "NCT03062358_inc_T34", "arg2_id": "NCT03062358_inc_T36", "normalized": [] }, { "id": "NCT03062358_inc_R23", "type": "Has_qualifier", "arg1_id": "NCT03062358_inc_T45", "arg2_id": "NCT03062358_inc_T44", "normalized": [] }, { "id": "NCT03062358_inc_R24", "type": "Has_qualifier", "arg1_id": "NCT03062358_inc_T50", "arg2_id": "NCT03062358_inc_T49", "normalized": [] }, { "id": "NCT03062358_inc_R25", "type": "AND", "arg1_id": "NCT03062358_inc_T46", "arg2_id": "NCT03062358_inc_T50", "normalized": [] }, { "id": "NCT03062358_inc_R26", "type": "Has_index", "arg1_id": "NCT03062358_inc_T40", "arg2_id": "NCT03062358_inc_T41", "normalized": [] }, { "id": "NCT03062358_inc_R27", "type": "Has_temporal", "arg1_id": "NCT03062358_inc_T38", "arg2_id": "NCT03062358_inc_T40", "normalized": [] }, { "id": "NCT03062358_inc_R28", "type": "Has_temporal", "arg1_id": "NCT03062358_inc_T57", "arg2_id": "NCT03062358_inc_T56", "normalized": [] }, { "id": "NCT03062358_inc_R29", "type": "Has_value", "arg1_id": "NCT03062358_inc_T57", "arg2_id": "NCT03062358_inc_T58", "normalized": [] }, { "id": "NCT03062358_inc_R30", "type": "Has_scope", "arg1_id": "NCT03062358_inc_T53", "arg2_id": "NCT03062358_inc_T57", "normalized": [] }, { "id": "NCT03062358_inc_R31", "type": "Has_index", "arg1_id": "NCT03062358_inc_T56", "arg2_id": "NCT03062358_inc_T59", "normalized": [] }, { "id": "NCT03062358_inc_R32", "type": "AND", "arg1_id": "NCT03062358_inc_T65", "arg2_id": "NCT03062358_inc_T60", "normalized": [] } ]

[ { "id": "NCT03063866_exc_text", "type": "exclusion", "text": [ "Emergent condition like hematemesis.\nPatients with moderate to severe hepatic encephalopathy.\nPatients with hepatopulmonary syndrome.\nPatients with known or suspected hypersensitivity to the used medication were also excluded from the study.\n" ], "offsets": [ [ 0, 242 ] ] } ]

[ { "id": "NCT03063866_exc_T1", "type": "Condition", "text": [ "hematemesis" ], "offsets": [ [ 24, 35 ] ], "normalized": [] }, { "id": "NCT03063866_exc_T2", "type": "Condition", "text": [ "Emergent condition" ], "offsets": [ [ 0, 18 ] ], "normalized": [] }, { "id": "NCT03063866_exc_T3", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 63, 69 ] ], "normalized": [] }, { "id": "NCT03063866_exc_T4", "type": "Qualifier", "text": [ "moderate" ], "offsets": [ [ 51, 59 ] ], "normalized": [] }, { "id": "NCT03063866_exc_T5", "type": "Condition", "text": [ "hepatic encephalopathy" ], "offsets": [ [ 70, 92 ] ], "normalized": [] }, { "id": "NCT03063866_exc_T6", "type": "Scope", "text": [ "moderate to severe" ], "offsets": [ [ 51, 69 ] ], "normalized": [] }, { "id": "NCT03063866_exc_T7", "type": "Condition", "text": [ "hepatopulmonary syndrome" ], "offsets": [ [ 108, 132 ] ], "normalized": [] }, { "id": "NCT03063866_exc_T8", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 167, 183 ] ], "normalized": [] }, { "id": "NCT03063866_exc_T9", "type": "Mood", "text": [ "suspected" ], "offsets": [ [ 157, 166 ] ], "normalized": [] }, { "id": "NCT03063866_exc_T10", "type": "Mood", "text": [ "known" ], "offsets": [ [ 148, 153 ] ], "normalized": [] }, { "id": "NCT03063866_exc_T11", "type": "Scope", "text": [ "known or suspected" ], "offsets": [ [ 148, 166 ] ], "normalized": [] }, { "id": "NCT03063866_exc_T12", "type": "Drug", "text": [ "used medication" ], "offsets": [ [ 191, 206 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03063866_exc_R1", "type": "Subsumes", "arg1_id": "NCT03063866_exc_T2", "arg2_id": "NCT03063866_exc_T1", "normalized": [] }, { "id": "NCT03063866_exc_R2", "type": "Has_scope", "arg1_id": "NCT03063866_exc_T5", "arg2_id": "NCT03063866_exc_T6", "normalized": [] }, { "id": "NCT03063866_exc_R3", "type": "Has_scope", "arg1_id": "NCT03063866_exc_T8", "arg2_id": "NCT03063866_exc_T11", "normalized": [] }, { "id": "NCT03063866_exc_R4", "type": "AND", "arg1_id": "NCT03063866_exc_T8", "arg2_id": "NCT03063866_exc_T12", "normalized": [] } ]

[ { "id": "NCT03063866_inc_text", "type": "inclusion", "text": [ "Patients aged between 40 and 60 years old.\nWith Child score B or C\nPresented for elective gastrointestinal endoscopy\n" ], "offsets": [ [ 0, 117 ] ] } ]

[ { "id": "NCT03063866_inc_T1", "type": "Person", "text": [ "aged" ], "offsets": [ [ 9, 13 ] ], "normalized": [] }, { "id": "NCT03063866_inc_T2", "type": "Value", "text": [ "between 40 and 60 years old" ], "offsets": [ [ 14, 41 ] ], "normalized": [] }, { "id": "NCT03063866_inc_T3", "type": "Measurement", "text": [ "Child score" ], "offsets": [ [ 48, 59 ] ], "normalized": [] }, { "id": "NCT03063866_inc_T4", "type": "Value", "text": [ "B" ], "offsets": [ [ 60, 61 ] ], "normalized": [] }, { "id": "NCT03063866_inc_T5", "type": "Value", "text": [ "C" ], "offsets": [ [ 65, 66 ] ], "normalized": [] }, { "id": "NCT03063866_inc_T6", "type": "Scope", "text": [ "B or C" ], "offsets": [ [ 60, 66 ] ], "normalized": [] }, { "id": "NCT03063866_inc_T7", "type": "Qualifier", "text": [ "elective" ], "offsets": [ [ 81, 89 ] ], "normalized": [] }, { "id": "NCT03063866_inc_T8", "type": "Procedure", "text": [ "gastrointestinal endoscopy" ], "offsets": [ [ 90, 116 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03063866_inc_R1", "type": "Has_value", "arg1_id": "NCT03063866_inc_T1", "arg2_id": "NCT03063866_inc_T2", "normalized": [] }, { "id": "NCT03063866_inc_R2", "type": "Has_scope", "arg1_id": "NCT03063866_inc_T3", "arg2_id": "NCT03063866_inc_T6", "normalized": [] }, { "id": "NCT03063866_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03063866_inc_T8", "arg2_id": "NCT03063866_inc_T7", "normalized": [] } ]

[ { "id": "NCT03064568_exc_text", "type": "exclusion", "text": [ "Patient with contraindication to misoprostol or vasopressin, personal history or cardiac or pulmonary disease, history of prior myomectomy\n" ], "offsets": [ [ 0, 139 ] ] } ]

[ { "id": "NCT03064568_exc_T1", "type": "Drug", "text": [ "misoprostol" ], "offsets": [ [ 33, 44 ] ], "normalized": [] }, { "id": "NCT03064568_exc_T2", "type": "Drug", "text": [ "vasopressin" ], "offsets": [ [ 48, 59 ] ], "normalized": [] }, { "id": "NCT03064568_exc_T3", "type": "Condition", "text": [ "contraindication" ], "offsets": [ [ 13, 29 ] ], "normalized": [] }, { "id": "NCT03064568_exc_T4", "type": "Scope", "text": [ "misoprostol or vasopressin" ], "offsets": [ [ 33, 59 ] ], "normalized": [] }, { "id": "NCT03064568_exc_T5", "type": "Observation", "text": [ "personal history" ], "offsets": [ [ 61, 77 ] ], "normalized": [] }, { "id": "NCT03064568_exc_T6", "type": "Condition", "text": [ "disease", "cardiac" ], "offsets": [ [ 102, 109 ], [ 81, 88 ] ], "normalized": [] }, { "id": "NCT03064568_exc_T7", "type": "Condition", "text": [ "pulmonary disease" ], "offsets": [ [ 92, 109 ] ], "normalized": [] }, { "id": "NCT03064568_exc_T8", "type": "Observation", "text": [ "history" ], "offsets": [ [ 111, 118 ] ], "normalized": [] }, { "id": "NCT03064568_exc_T9", "type": "Temporal", "text": [ "prior" ], "offsets": [ [ 122, 127 ] ], "normalized": [] }, { "id": "NCT03064568_exc_T10", "type": "Procedure", "text": [ "myomectomy" ], "offsets": [ [ 128, 138 ] ], "normalized": [] }, { "id": "NCT03064568_exc_T11", "type": "Scope", "text": [ "cardiac or pulmonary disease" ], "offsets": [ [ 81, 109 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03064568_exc_R1", "type": "Has_scope", "arg1_id": "NCT03064568_exc_T3", "arg2_id": "NCT03064568_exc_T4", "normalized": [] }, { "id": "NCT03064568_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03064568_exc_T10", "arg2_id": "NCT03064568_exc_T9", "normalized": [] }, { "id": "NCT03064568_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03064568_exc_T10", "arg2_id": "NCT03064568_exc_T8", "normalized": [] }, { "id": "NCT03064568_exc_R4", "type": "Has_temporal", "arg1_id": "NCT03064568_exc_T11", "arg2_id": "NCT03064568_exc_T5", "normalized": [] } ]

[ { "id": "NCT03064568_inc_text", "type": "inclusion", "text": [ "Female age 20-50 y/o who plan to undergo abdominal myomectomy for symptomatic myomatous uterus\n" ], "offsets": [ [ 0, 95 ] ] } ]

[ { "id": "NCT03064568_inc_T1", "type": "Person", "text": [ "Female" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "NCT03064568_inc_T2", "type": "Person", "text": [ "age" ], "offsets": [ [ 7, 10 ] ], "normalized": [] }, { "id": "NCT03064568_inc_T3", "type": "Value", "text": [ "20-50 y/o" ], "offsets": [ [ 11, 20 ] ], "normalized": [] }, { "id": "NCT03064568_inc_T4", "type": "Mood", "text": [ "plan to undergo" ], "offsets": [ [ 25, 40 ] ], "normalized": [] }, { "id": "NCT03064568_inc_T5", "type": "Procedure", "text": [ "abdominal myomectomy" ], "offsets": [ [ 41, 61 ] ], "normalized": [] }, { "id": "NCT03064568_inc_T6", "type": "Qualifier", "text": [ "symptomatic" ], "offsets": [ [ 66, 77 ] ], "normalized": [] }, { "id": "NCT03064568_inc_T7", "type": "Condition", "text": [ "myomatous uterus" ], "offsets": [ [ 78, 94 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03064568_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03064568_inc_T7", "arg2_id": "NCT03064568_inc_T6", "normalized": [] }, { "id": "NCT03064568_inc_R2", "type": "AND", "arg1_id": "NCT03064568_inc_T5", "arg2_id": "NCT03064568_inc_T7", "normalized": [] }, { "id": "NCT03064568_inc_R3", "type": "Has_mood", "arg1_id": "NCT03064568_inc_T5", "arg2_id": "NCT03064568_inc_T4", "normalized": [] }, { "id": "NCT03064568_inc_R4", "type": "Has_value", "arg1_id": "NCT03064568_inc_T2", "arg2_id": "NCT03064568_inc_T3", "normalized": [] } ]

[ { "id": "NCT03064867_exc_text", "type": "exclusion", "text": [ "Prior treatment toxicities have not resolved to < Grade 2 according to NCI CTCAE Version 4.0 (except clinically insignificant toxicities such as alopecia). \nSubjects receiving any other investigational agents. \nPatients with active tumor lysis syndrome (TLS) either from laboratory or clinical changes. \nPatients with active central nervous system (CNS) disease defined as symptomatic meningeal lymphoma or known CNS parenchymal lymphoma. \nHistory of severe allergic reactions attributed to compounds of similar chemical or biologic composition to rituximab or other agents used in this study. \nSubjects with uncontrolled intercurrent illness . \nHIV-positive subjects on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with Venetoclax. In addition, these subjects are at increased risk of lethal infections when treated with marrow suppressive therapy. Appropriate studies will be undertaken in subjects receiving combination antiretroviral therapy when indicated. HIV testing prior to enrollment is not required for screening but strongly encouraged for patients with no documented prior HIV assessment. \nPresence of positive test results for hepatitis B virus (HBV), hepatitis B surface antigen (HBsAg), or hepatitis C (HCV) antibody. \nPatients who are positive for HCV antibody must be negative for HCV by polymerase chain reaction (PCR) to be eligible for study participation \nPatients with occult or prior HBV infection (defined as positive total hepatitis B core antibody [HBcAb] and negative HBsAg) may be included if HBV DNA is undetectable. These patients must be willing to undergo monthly DNA testing. \nWomen who are pregnant or lactating \nMalabsorption syndrome or other condition that precludes enteral route of administration \nChemotherapy or radiation within 3 weeks of the first scheduled study treatment. \nLess than 2-year disease free from another primary malignancy (other than squamous or basal cell carcinoma of the skin, \"in-situ\" carcinoma of the cervix or breast, superficial bladder carcinoma, or previously treated localized prostate cancer with normal prostate specific antigen (PSA) levels). Patients who have had completed all anti-cancer treatment for another primary malignancy more than 2 years prior to screening are eligible if they are not considered to have a \"currently active\" malignancy based on having less than a 30% risk of relapse. \nMajor surgery, other than diagnostic surgery, within 2 weeks. \nMedical condition requiring chronic use of high dose systemic corticosteroids (i.e., doses of prednisone higher than 10 mg/day or equivalent). Brief (<15 days) treatment with glucocorticoids (prednisone 100 mg by mouth daily, or equivalent) is acceptable. \nKnown allergy to both xanthine oxidase inhibitors and rasburicase. \nUse of warfarin is prohibited. Anticoagulation with low-molecular weight heparin (i.e. enoxaparin) or direct thrombin inhibitors is permitted. \nThe following concomitant medications are not allowed from 7 days prior to the first dose of study drug and during venetoclax administration: Strong CYP3A4 inhibitors including but not limited to fluconazole, ketoconazole, and clarithromycin or strong CYP3A4 inducers included but not limited to rifampin, carbamazepine. \nReceipt of live-virus vaccines within 28 days prior to the initiation of study treatment or need for live-virus vaccines at any time during study treatment. \nConcomitant medications that fall into the categories below could potentially lead to adverse reactions and should be considered cautionary. \nModerate/Weak CYP3A inducers such as efavirenz and oxcarbazepine \nCYP2C8 substrates such as thiazolidinediones (glitazones) and select statins (because of expected inhibition of the metabolism of CYP2C8 substrates) by venetoclax \nCYP2C9 substrates such as tolbutamide (because of expected inhibition of the metabolism of CYP2C9 substrates by venetoclax. It is recommended to exclude CYP2C9 substrates with a narrow therapeutic index such as phenytoin. \n \n" ], "offsets": [ [ 0, 4054 ] ] } ]

[ { "id": "NCT03064867_exc_T3", "type": "Condition", "text": [ "tumor lysis syndrome (TLS)" ], "offsets": [ [ 232, 258 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T4", "type": "Condition", "text": [ "central nervous system (CNS) disease" ], "offsets": [ [ 325, 361 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T5", "type": "Condition", "text": [ "meningeal lymphoma" ], "offsets": [ [ 385, 403 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T6", "type": "Qualifier", "text": [ "symptomatic" ], "offsets": [ [ 373, 384 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T7", "type": "Condition", "text": [ "CNS parenchymal lymphoma" ], "offsets": [ [ 413, 437 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T8", "type": "Scope", "text": [ "symptomatic meningeal lymphoma or known CNS parenchymal lymphoma" ], "offsets": [ [ 373, 437 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T9", "type": "Condition", "text": [ "allergic reactions" ], "offsets": [ [ 458, 476 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T10", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 451, 457 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T12", "type": "Drug", "text": [ "compounds of similar chemical or biologic composition to rituximab" ], "offsets": [ [ 491, 557 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T11", "type": "Drug", "text": [ "compounds of similar chemical or biologic composition to", "other agents used in this study" ], "offsets": [ [ 491, 547 ], [ 561, 592 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T14", "type": "Scope", "text": [ "compounds of similar chemical or biologic composition to rituximab or other agents used in this study" ], "offsets": [ [ 491, 592 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T16", "type": "Condition", "text": [ "HIV-positive" ], "offsets": [ [ 646, 658 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T17", "type": "Procedure", "text": [ "combination antiretroviral therapy" ], "offsets": [ [ 671, 705 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T23", "type": "Measurement", "text": [ "hepatitis B virus (HBV)" ], "offsets": [ [ 1204, 1227 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T24", "type": "Measurement", "text": [ "hepatitis B surface antigen (HBsAg)" ], "offsets": [ [ 1229, 1264 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T25", "type": "Measurement", "text": [ "hepatitis C (HCV) antibody" ], "offsets": [ [ 1269, 1295 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T26", "type": "Value", "text": [ "positive" ], "offsets": [ [ 1178, 1186 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T27", "type": "Measurement", "text": [ "HCV antibody" ], "offsets": [ [ 1328, 1340 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T28", "type": "Value", "text": [ "positive" ], "offsets": [ [ 1315, 1323 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T29", "type": "Measurement", "text": [ "HCV" ], "offsets": [ [ 1362, 1365 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T30", "type": "Value", "text": [ "negative" ], "offsets": [ [ 1349, 1357 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T31", "type": "Scope", "text": [ "positive for HCV antibody" ], "offsets": [ [ 1315, 1340 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T32", "type": "Procedure", "text": [ "polymerase chain reaction (PCR)" ], "offsets": [ [ 1369, 1400 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T33", "type": "Condition", "text": [ "HBV infection" ], "offsets": [ [ 1471, 1484 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T34", "type": "Measurement", "text": [ "total hepatitis B core antibody [HBcAb]" ], "offsets": [ [ 1506, 1545 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T35", "type": "Value", "text": [ "positive" ], "offsets": [ [ 1497, 1505 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T36", "type": "Measurement", "text": [ "HBsAg" ], "offsets": [ [ 1559, 1564 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T37", "type": "Value", "text": [ "negative" ], "offsets": [ [ 1550, 1558 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T38", "type": "Measurement", "text": [ "HBV DNA" ], "offsets": [ [ 1585, 1592 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T39", "type": "Value", "text": [ "undetectable" ], "offsets": [ [ 1596, 1608 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T40", "type": "Scope", "text": [ "positive total hepatitis B core antibody [HBcAb] and negative HBsAg" ], "offsets": [ [ 1497, 1564 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T43", "type": "Person", "text": [ "Women" ], "offsets": [ [ 1674, 1679 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T44", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 1688, 1696 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T45", "type": "Condition", "text": [ "lactating" ], "offsets": [ [ 1700, 1709 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T46", "type": "Condition", "text": [ "Malabsorption syndrome" ], "offsets": [ [ 1711, 1733 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T47", "type": "Condition", "text": [ "condition that precludes enteral route of administration" ], "offsets": [ [ 1743, 1799 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T49", "type": "Drug", "text": [ "Chemotherapy" ], "offsets": [ [ 1801, 1813 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T50", "type": "Procedure", "text": [ "radiation" ], "offsets": [ [ 1817, 1826 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T51", "type": "Temporal", "text": [ "within 3 weeks of the first scheduled study treatment" ], "offsets": [ [ 1827, 1880 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T52", "type": "Reference_point", "text": [ "the first scheduled study treatment" ], "offsets": [ [ 1845, 1880 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T53", "type": "Temporal", "text": [ "Less than 2-year" ], "offsets": [ [ 1883, 1899 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T54", "type": "Condition", "text": [ "disease free" ], "offsets": [ [ 1900, 1912 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T55", "type": "Condition", "text": [ "primary malignancy" ], "offsets": [ [ 1926, 1944 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T56", "type": "Qualifier", "text": [ "another" ], "offsets": [ [ 1918, 1925 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T57", "type": "Condition", "text": [ "squamous or basal cell carcinoma of the skin" ], "offsets": [ [ 1957, 2001 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T58", "type": "Condition", "text": [ "\"in-situ\" carcinoma of the cervix" ], "offsets": [ [ 2003, 2036 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T59", "type": "Condition", "text": [ "\"in-situ\" carcinoma of the cervix", "breast" ], "offsets": [ [ 2003, 2036 ], [ 2040, 2046 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T60", "type": "Condition", "text": [ "superficial bladder carcinoma" ], "offsets": [ [ 2048, 2077 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T61", "type": "Condition", "text": [ "localized prostate cancer" ], "offsets": [ [ 2101, 2126 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T62", "type": "Measurement", "text": [ "prostate specific antigen (PSA) levels" ], "offsets": [ [ 2139, 2177 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T63", "type": "Value", "text": [ "normal" ], "offsets": [ [ 2132, 2138 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T64", "type": "Scope", "text": [ "squamous or basal cell carcinoma of the skin, \"in-situ\" carcinoma of the cervix or breast, superficial bladder carcinoma, or previously treated localized prostate cancer with normal prostate specific antigen (PSA) levels" ], "offsets": [ [ 1957, 2177 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T65", "type": "Procedure", "text": [ "anti-cancer treatment" ], "offsets": [ [ 2216, 2237 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T66", "type": "Condition", "text": [ "primary malignancy" ], "offsets": [ [ 2250, 2268 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T67", "type": "Qualifier", "text": [ "another" ], "offsets": [ [ 2242, 2249 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T68", "type": "Temporal", "text": [ "more than 2 years prior" ], "offsets": [ [ 2269, 2292 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T69", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 2296, 2305 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T70", "type": "Negation", "text": [ "are eligible" ], "offsets": [ [ 2306, 2318 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T71", "type": "Procedure", "text": [ "Major surgery" ], "offsets": [ [ 2436, 2449 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T72", "type": "Procedure", "text": [ "diagnostic surgery" ], "offsets": [ [ 2462, 2480 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T73", "type": "Temporal", "text": [ "within 2 weeks" ], "offsets": [ [ 2482, 2496 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T74", "type": "Drug", "text": [ "systemic corticosteroids" ], "offsets": [ [ 2552, 2576 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T75", "type": "Drug", "text": [ "prednisone" ], "offsets": [ [ 2593, 2603 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T76", "type": "Multiplier", "text": [ "higher than 10 mg/day" ], "offsets": [ [ 2604, 2625 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T77", "type": "Multiplier", "text": [ "high dose" ], "offsets": [ [ 2542, 2551 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T78", "type": "Condition", "text": [ "Medical condition" ], "offsets": [ [ 2499, 2516 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T80", "type": "Temporal", "text": [ "chronic" ], "offsets": [ [ 2527, 2534 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T81", "type": "Scope", "text": [ "doses of prednisone higher than 10 mg/day" ], "offsets": [ [ 2584, 2625 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T82", "type": "Temporal", "text": [ "<15 days" ], "offsets": [ [ 2649, 2657 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T83", "type": "Drug", "text": [ "glucocorticoids" ], "offsets": [ [ 2674, 2689 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T84", "type": "Drug", "text": [ "prednisone" ], "offsets": [ [ 2691, 2701 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T85", "type": "Multiplier", "text": [ "100 mg", "daily" ], "offsets": [ [ 2702, 2708 ], [ 2718, 2723 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T87", "type": "Drug", "text": [ "xanthine oxidase inhibitors" ], "offsets": [ [ 2778, 2805 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T88", "type": "Drug", "text": [ "rasburicase" ], "offsets": [ [ 2810, 2821 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T89", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 2762, 2769 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T90", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 2762, 2769 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T91", "type": "Drug", "text": [ "warfarin" ], "offsets": [ [ 2831, 2839 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T92", "type": "Procedure", "text": [ "Anticoagulation" ], "offsets": [ [ 2855, 2870 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T93", "type": "Drug", "text": [ "low-molecular weight heparin" ], "offsets": [ [ 2876, 2904 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T94", "type": "Drug", "text": [ "enoxaparin" ], "offsets": [ [ 2911, 2921 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T95", "type": "Drug", "text": [ "direct thrombin inhibitors" ], "offsets": [ [ 2926, 2952 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T97", "type": "Temporal", "text": [ "7 days prior" ], "offsets": [ [ 3027, 3039 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T98", "type": "Reference_point", "text": [ "first dose of study drug" ], "offsets": [ [ 3047, 3071 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T99", "type": "Drug", "text": [ "venetoclax" ], "offsets": [ [ 3083, 3093 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T100", "type": "Procedure", "text": [ "venetoclax administration" ], "offsets": [ [ 3083, 3108 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T101", "type": "Drug", "text": [ "Strong CYP3A4 inhibitors" ], "offsets": [ [ 3110, 3134 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T102", "type": "Drug", "text": [ "fluconazole" ], "offsets": [ [ 3164, 3175 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T103", "type": "Drug", "text": [ "ketoconazole" ], "offsets": [ [ 3177, 3189 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T104", "type": "Drug", "text": [ "clarithromycin" ], "offsets": [ [ 3195, 3209 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T105", "type": "Drug", "text": [ "strong CYP3A4 inducers" ], "offsets": [ [ 3213, 3235 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T106", "type": "Drug", "text": [ "rifampin" ], "offsets": [ [ 3264, 3272 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T107", "type": "Drug", "text": [ "carbamazepine" ], "offsets": [ [ 3274, 3287 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T108", "type": "Scope", "text": [ "rifampin, carbamazepine" ], "offsets": [ [ 3264, 3287 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T109", "type": "Scope", "text": [ "fluconazole, ketoconazole, and clarithromycin" ], "offsets": [ [ 3164, 3209 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T110", "type": "Scope", "text": [ "7 days prior to the first dose of study drug and during venetoclax administration" ], "offsets": [ [ 3027, 3108 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T111", "type": "Scope", "text": [ "Strong CYP3A4 inhibitors including but not limited to fluconazole, ketoconazole, and clarithromycin or strong CYP3A4 inducers included but not limited to rifampin, carbamazepine" ], "offsets": [ [ 3110, 3287 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T112", "type": "Drug", "text": [ "live-virus vaccines" ], "offsets": [ [ 3301, 3320 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T113", "type": "Temporal", "text": [ "within 28 days prior" ], "offsets": [ [ 3321, 3341 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T114", "type": "Reference_point", "text": [ "the initiation of study treatment" ], "offsets": [ [ 3345, 3378 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T116", "type": "Drug", "text": [ "live-virus vaccines" ], "offsets": [ [ 3391, 3410 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T117", "type": "Temporal", "text": [ "any time during" ], "offsets": [ [ 3414, 3429 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T118", "type": "Reference_point", "text": [ "study treatment" ], "offsets": [ [ 3430, 3445 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T119", "type": "Observation", "text": [ "need for" ], "offsets": [ [ 3382, 3390 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T122", "type": "Drug", "text": [ "Weak CYP3A inducers" ], "offsets": [ [ 3599, 3618 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T123", "type": "Drug", "text": [ "Moderate", "CYP3A inducers" ], "offsets": [ [ 3590, 3598 ], [ 3604, 3618 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T124", "type": "Drug", "text": [ "efavirenz" ], "offsets": [ [ 3627, 3636 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T125", "type": "Drug", "text": [ "oxcarbazepine" ], "offsets": [ [ 3641, 3654 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T126", "type": "Scope", "text": [ "Moderate/Weak CYP3A inducers" ], "offsets": [ [ 3590, 3618 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T127", "type": "Scope", "text": [ "efavirenz and oxcarbazepine" ], "offsets": [ [ 3627, 3654 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T128", "type": "Drug", "text": [ "CYP2C8 substrates" ], "offsets": [ [ 3656, 3673 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T130", "type": "Drug", "text": [ "thiazolidinediones" ], "offsets": [ [ 3682, 3700 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T131", "type": "Drug", "text": [ "glitazones" ], "offsets": [ [ 3702, 3712 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T132", "type": "Drug", "text": [ "statins" ], "offsets": [ [ 3725, 3732 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T133", "type": "Qualifier", "text": [ "select" ], "offsets": [ [ 3718, 3724 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T134", "type": "Drug", "text": [ "CYP2C9 substrates" ], "offsets": [ [ 3820, 3837 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T135", "type": "Drug", "text": [ "tolbutamide" ], "offsets": [ [ 3846, 3857 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T136", "type": "Drug", "text": [ "CYP2C9 substrates" ], "offsets": [ [ 3973, 3990 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T137", "type": "Drug", "text": [ "phenytoin" ], "offsets": [ [ 4031, 4040 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T138", "type": "Qualifier", "text": [ "narrow therapeutic index" ], "offsets": [ [ 3998, 4022 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T19", "type": "Negation", "text": [ "other than" ], "offsets": [ [ 2451, 2461 ] ], "normalized": [] }, { "id": "NCT03064867_exc_T140", "type": "Negation", "text": [ "other than" ], "offsets": [ [ 1946, 1956 ] ], "normalized": [] } ]

[]

[]

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"NCT03064867_exc_R8", "type": "Has_value", "arg1_id": "NCT03064867_exc_T27", "arg2_id": "NCT03064867_exc_T28", "normalized": [] }, { "id": "NCT03064867_exc_R9", "type": "Has_value", "arg1_id": "NCT03064867_exc_T29", "arg2_id": "NCT03064867_exc_T30", "normalized": [] }, { "id": "NCT03064867_exc_R10", "type": "AND", "arg1_id": "NCT03064867_exc_T31", "arg2_id": "NCT03064867_exc_T29", "normalized": [] }, { "id": "NCT03064867_exc_R11", "type": "AND", "arg1_id": "NCT03064867_exc_T29", "arg2_id": "NCT03064867_exc_T32", "normalized": [] }, { "id": "NCT03064867_exc_R12", "type": "Has_value", "arg1_id": "NCT03064867_exc_T36", "arg2_id": "NCT03064867_exc_T37", "normalized": [] }, { "id": "NCT03064867_exc_R13", "type": "Has_value", "arg1_id": "NCT03064867_exc_T34", "arg2_id": "NCT03064867_exc_T35", "normalized": [] }, { "id": "NCT03064867_exc_R14", "type": "Has_value", "arg1_id": "NCT03064867_exc_T38", "arg2_id": "NCT03064867_exc_T39", "normalized": [] }, { "id": "NCT03064867_exc_R15", "type": "Has_scope", "arg1_id": "NCT03064867_exc_T33", "arg2_id": "NCT03064867_exc_T40", "normalized": [] }, { "id": "NCT03064867_exc_R16", "type": "AND", "arg1_id": "NCT03064867_exc_T33", "arg2_id": "NCT03064867_exc_T38", "normalized": [] }, { "id": "NCT03064867_exc_R17", "type": "AND", "arg1_id": "NCT03064867_exc_T43", "arg2_id": "NCT03064867_exc_T44", "normalized": [] }, { "id": "NCT03064867_exc_R18", "type": "Has_index", "arg1_id": "NCT03064867_exc_T51", "arg2_id": "NCT03064867_exc_T52", "normalized": [] }, { "id": "NCT03064867_exc_R19", "type": "Has_temporal", "arg1_id": "NCT03064867_exc_T50", "arg2_id": "NCT03064867_exc_T51", "normalized": [] }, { "id": "NCT03064867_exc_R20", "type": "Has_temporal", "arg1_id": "NCT03064867_exc_T49", "arg2_id": "NCT03064867_exc_T51", "normalized": [] }, { "id": "NCT03064867_exc_R21", "type": "Has_qualifier", "arg1_id": "NCT03064867_exc_T55", "arg2_id": "NCT03064867_exc_T56", "normalized": [] }, { "id": "NCT03064867_exc_R22", "type": "Has_temporal", "arg1_id": "NCT03064867_exc_T54", "arg2_id": "NCT03064867_exc_T53", "normalized": [] }, { "id": "NCT03064867_exc_R23", "type": "AND", "arg1_id": "NCT03064867_exc_T54", "arg2_id": "NCT03064867_exc_T55", "normalized": [] }, { "id": "NCT03064867_exc_R24", "type": "Has_value", "arg1_id": "NCT03064867_exc_T62", "arg2_id": "NCT03064867_exc_T63", "normalized": [] }, { "id": "NCT03064867_exc_R25", "type": "AND", "arg1_id": "NCT03064867_exc_T61", "arg2_id": "NCT03064867_exc_T62", "normalized": [] }, { "id": "NCT03064867_exc_R27", "type": "Has_qualifier", "arg1_id": "NCT03064867_exc_T66", "arg2_id": "NCT03064867_exc_T67", "normalized": [] }, { "id": "NCT03064867_exc_R28", "type": "Has_index", "arg1_id": "NCT03064867_exc_T68", "arg2_id": "NCT03064867_exc_T69", "normalized": [] }, { "id": "NCT03064867_exc_R29", "type": "AND", "arg1_id": "NCT03064867_exc_T65", "arg2_id": "NCT03064867_exc_T66", "normalized": [] }, { "id": "NCT03064867_exc_R30", "type": "Has_temporal", "arg1_id": "NCT03064867_exc_T65", "arg2_id": "NCT03064867_exc_T68", "normalized": [] }, { "id": "NCT03064867_exc_R32", "type": "Has_temporal", "arg1_id": "NCT03064867_exc_T71", "arg2_id": "NCT03064867_exc_T73", "normalized": [] }, { "id": "NCT03064867_exc_R33", "type": "Has_multiplier", "arg1_id": "NCT03064867_exc_T74", "arg2_id": "NCT03064867_exc_T77", "normalized": [] }, { "id": "NCT03064867_exc_R34", "type": "Has_multiplier", "arg1_id": "NCT03064867_exc_T75", "arg2_id": "NCT03064867_exc_T76", "normalized": [] }, { "id": "NCT03064867_exc_R35", "type": "Has_temporal", "arg1_id": "NCT03064867_exc_T74", "arg2_id": "NCT03064867_exc_T80", "normalized": [] }, { "id": "NCT03064867_exc_R36", "type": "AND", "arg1_id": "NCT03064867_exc_T78", "arg2_id": "NCT03064867_exc_T74", "normalized": [] }, { "id": "NCT03064867_exc_R37", "type": "Subsumes", "arg1_id": "NCT03064867_exc_T77", "arg2_id": "NCT03064867_exc_T81", "normalized": [] }, { "id": "NCT03064867_exc_R38", "type": "Has_multiplier", "arg1_id": "NCT03064867_exc_T84", "arg2_id": "NCT03064867_exc_T85", "normalized": [] }, { "id": "NCT03064867_exc_R39", "type": "Has_temporal", "arg1_id": "NCT03064867_exc_T83", "arg2_id": "NCT03064867_exc_T82", "normalized": [] }, { "id": "NCT03064867_exc_R40", "type": "Subsumes", "arg1_id": "NCT03064867_exc_T83", "arg2_id": "NCT03064867_exc_T84", "normalized": [] }, { "id": "NCT03064867_exc_R41", "type": "AND", "arg1_id": "NCT03064867_exc_T89", "arg2_id": "NCT03064867_exc_T87", "normalized": [] }, { "id": "NCT03064867_exc_R42", "type": "AND", "arg1_id": "NCT03064867_exc_T90", "arg2_id": "NCT03064867_exc_T88", "normalized": [] }, { "id": "NCT03064867_exc_R43", "type": "Subsumes", "arg1_id": "NCT03064867_exc_T93", "arg2_id": "NCT03064867_exc_T94", "normalized": [] }, { "id": "NCT03064867_exc_R44", "type": "AND", "arg1_id": "NCT03064867_exc_T92", "arg2_id": "NCT03064867_exc_T93", "normalized": [] }, { "id": "NCT03064867_exc_R45", "type": "Subsumes", "arg1_id": "NCT03064867_exc_T105", "arg2_id": "NCT03064867_exc_T108", "normalized": [] }, { "id": "NCT03064867_exc_R46", "type": "Subsumes", "arg1_id": "NCT03064867_exc_T101", "arg2_id": "NCT03064867_exc_T109", "normalized": [] }, { "id": "NCT03064867_exc_R47", "type": "Has_index", "arg1_id": "NCT03064867_exc_T97", "arg2_id": "NCT03064867_exc_T98", "normalized": [] }, { "id": "NCT03064867_exc_R48", "type": "Has_scope", "arg1_id": "NCT03064867_exc_T110", "arg2_id": "NCT03064867_exc_T111", "normalized": [] }, { "id": "NCT03064867_exc_R49", "type": "Has_index", "arg1_id": "NCT03064867_exc_T117", "arg2_id": "NCT03064867_exc_T118", "normalized": [] }, { "id": "NCT03064867_exc_R50", "type": "Has_temporal", "arg1_id": "NCT03064867_exc_T116", "arg2_id": "NCT03064867_exc_T117", "normalized": [] }, { "id": "NCT03064867_exc_R52", "type": "Has_temporal", "arg1_id": "NCT03064867_exc_T112", "arg2_id": "NCT03064867_exc_T113", "normalized": [] }, { "id": "NCT03064867_exc_R53", "type": "Has_index", "arg1_id": "NCT03064867_exc_T113", "arg2_id": "NCT03064867_exc_T114", "normalized": [] }, { "id": "NCT03064867_exc_R54", "type": "Subsumes", "arg1_id": "NCT03064867_exc_T126", "arg2_id": "NCT03064867_exc_T127", "normalized": [] }, { "id": "NCT03064867_exc_R55", "type": "Subsumes", "arg1_id": "NCT03064867_exc_T130", "arg2_id": "NCT03064867_exc_T131", "normalized": [] }, { "id": "NCT03064867_exc_R56", "type": "Has_qualifier", "arg1_id": "NCT03064867_exc_T132", "arg2_id": "NCT03064867_exc_T133", "normalized": [] }, { "id": "NCT03064867_exc_R57", "type": "Subsumes", "arg1_id": "NCT03064867_exc_T128", "arg2_id": "NCT03064867_exc_T130", "normalized": [] }, { "id": "NCT03064867_exc_R58", "type": "Subsumes", "arg1_id": "NCT03064867_exc_T134", "arg2_id": "NCT03064867_exc_T135", "normalized": [] }, { "id": "NCT03064867_exc_R59", "type": "Has_qualifier", "arg1_id": "NCT03064867_exc_T136", "arg2_id": "NCT03064867_exc_T138", "normalized": [] }, { "id": "NCT03064867_exc_R60", "type": "Subsumes", "arg1_id": "NCT03064867_exc_T136", "arg2_id": "NCT03064867_exc_T137", "normalized": [] }, { "id": "NCT03064867_exc_R61", "type": "AND", "arg1_id": "NCT03064867_exc_T16", "arg2_id": "NCT03064867_exc_T17", "normalized": [] }, { "id": "NCT03064867_exc_R31", "type": "AND", "arg1_id": "NCT03064867_exc_T71", "arg2_id": "NCT03064867_exc_T72", "normalized": [] }, { "id": "NCT03064867_exc_R62", "type": "Has_negation", "arg1_id": "NCT03064867_exc_T72", "arg2_id": "NCT03064867_exc_T19", "normalized": [] }, { "id": "NCT03064867_exc_R26", "type": "Has_negation", "arg1_id": "NCT03064867_exc_T64", "arg2_id": "NCT03064867_exc_T140", "normalized": [] }, { "id": "NCT03064867_exc_R63", "type": "Has_scope", "arg1_id": "NCT03064867_exc_T54", "arg2_id": "NCT03064867_exc_T64", "normalized": [] }, { "id": "NCT03064867_exc_R64", "type": "Has_negation", "arg1_id": "NCT03064867_exc_T65", "arg2_id": "NCT03064867_exc_T70", "normalized": [] } ]

[ { "id": "NCT03064867_inc_text", "type": "inclusion", "text": [ "Histological confirmation of relapsed/refractory diffuse large B-cell lymphoma after prior rituximab and anthracycline-containing systemic treatment regimen such as R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone), R-EPOCH (rituximab, etoposide phosphate, prednisone, vincristine sulfate, cyclophosphamide, doxorubicin hydrochloride), R-HyperCVAD (rituximab, cyclophosphamide, vincristine sulfate, doxorubicin hydrochloride, dexamethasone) etc. \nSubjects must have received no more than 2 prior systemic therapies for lymphoma. Prior therapy with systemic rituximab monotherapy or conventional chemotherapy (i.e. bendamustine, CVP (Cyclophosphamide, Vincristine Sulfate, Prednisone) or other) ± rituximab for indolent non-Hodgkin's lymphoma (NHL) ± maintenance/extended-use rituximab will count as 1 line of systemic therapy. \nEastern Cooperative Oncology Group (ECOG) Performance status ≤ 2 \nSubjects must have normal organ and marrow function as defined below: \nHemoglobin ≥ 8.0 g/dl \nAbsolute neutrophil count ≥ 1,000/mcL \nPlatelet count ≥ 75,000/mcL \nTotal bilirubin ≤ 1.5 X the upper limit of normal (ULN) unless a known history of impaired bilirubin conjugation such as Gilbert's, for whom the maximum will be 2.5 ULN. \nAspartate transaminase (AST) (SGOT) ≤ 2.5 X institutional ULN \nAlanine transaminase (ALT) (SGPT) ≤ 2.5 X institutional ULN \nInternational normalized ratio (INR) > 1.5 ×ULN \nPatients must have a calculated serum creatinine clearance > 50 mL/min using Cockcroft-Gault calculation or based on 24-hour urine collection performed within 7 days prior to treatment. \nSpecific guidelines will be followed regarding inclusion of relapsed/refractory DLBCL based on Hepatitis B serological testing as follow: \nHBsAg negative, HBcAb negative, HBsAb positive patients are eligible. \nPatients who test positive for HBsAg are ineligible \nPatients with HBsAg negative, but HBcAb positive (regardless of HBsAb status) should have a HBV DNA testing performed and protocol eligibility determined as follow: \nIf HBV DNA is positive, the subject is ineligible. \nIf HBV DNA is negative, the subject may be included but must undergo HBV DNA PCR testing monthly x 3 months beginning from the start of treatment \nSubjects must have the ability to understand and the willingness to sign a written informed consent document. \nFor women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use a contraceptive method with a failure rate of < 1% per year during the treatment period and for at least 30 days after the last dose of venetoclax or 18 months after the last dose of rituximab, whichever is longer. \nA woman is considered to be of childbearing potential if she is postmenarcheal, has not reached a postmenopausal state (< 12 continuous months of amenorrhea with no identified cause other than menopause), and has not undergone surgical sterilization (removal of ovaries and/or uterus). \nFor men: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures, and agreement to refrain from donating sperm, as defined below: \nWith female partners of childbearing potential, men must remain abstinent or use a condom plus an additional contraceptive method that together result in a failure rate of < 1% per year during the treatment period and for at least 6 months after the last dose of rituximab. Men must refrain from donating sperm during this same period. \nWith pregnant female partners, men must remain abstinent or use a condom during the treatment period and for at least 6 months after the last dose of rituximab to avoid exposing the embryo. \n" ], "offsets": [ [ 0, 3675 ] ] } ]

[ { "id": "NCT03064867_inc_T1", "type": "Procedure", "text": [ "Histological" ], "offsets": [ [ 0, 12 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T2", "type": "Value", "text": [ "confirmation" ], "offsets": [ [ 13, 25 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T3", "type": "Condition", "text": [ "B-cell lymphoma" ], "offsets": [ [ 63, 78 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T4", "type": "Qualifier", "text": [ "large" ], "offsets": [ [ 57, 62 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T5", "type": "Qualifier", "text": [ "diffuse" ], "offsets": [ [ 49, 56 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T7", "type": "Procedure", "text": [ "rituximab and anthracycline-containing systemic treatment regimen" ], "offsets": [ [ 91, 156 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T8", "type": "Drug", "text": [ "R-CHOP" ], "offsets": [ [ 165, 171 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T9", "type": "Drug", "text": [ "rituximab" ], "offsets": [ [ 173, 182 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T10", "type": "Drug", "text": [ "cyclophosphamide" ], "offsets": [ [ 184, 200 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T11", "type": "Drug", "text": [ "doxorubicin" ], "offsets": [ [ 202, 213 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T12", "type": "Drug", "text": [ "vincristine" ], "offsets": [ [ 215, 226 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T13", "type": "Drug", "text": [ "prednisone" ], "offsets": [ [ 232, 242 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T14", "type": "Scope", "text": [ "rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone" ], "offsets": [ [ 173, 242 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T15", "type": "Drug", "text": [ "R-EPOCH" ], "offsets": [ [ 245, 252 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T16", "type": "Drug", "text": [ "rituximab" ], "offsets": [ [ 254, 263 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T17", "type": "Drug", "text": [ "etoposide phosphate" ], "offsets": [ [ 265, 284 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T18", "type": "Drug", "text": [ "prednisone" ], "offsets": [ [ 286, 296 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T19", "type": "Drug", "text": [ "vincristine sulfate" ], "offsets": [ [ 298, 317 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T20", "type": "Drug", "text": [ "cyclophosphamide" ], "offsets": [ [ 319, 335 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T21", "type": "Drug", "text": [ "doxorubicin hydrochloride" ], "offsets": [ [ 337, 362 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T22", "type": "Scope", "text": [ "rituximab, etoposide phosphate, prednisone, vincristine sulfate, cyclophosphamide, doxorubicin hydrochloride" ], "offsets": [ [ 254, 362 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T23", "type": "Drug", "text": [ "R-HyperCVAD" ], "offsets": [ [ 365, 376 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T24", "type": "Drug", "text": [ "rituximab" ], "offsets": [ [ 378, 387 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T25", "type": "Drug", "text": [ "cyclophosphamide" ], "offsets": [ [ 389, 405 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T26", "type": "Drug", "text": [ "vincristine sulfate" ], "offsets": [ [ 407, 426 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T27", "type": "Drug", "text": [ "doxorubicin hydrochloride" ], "offsets": [ [ 428, 453 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T28", "type": "Drug", "text": [ "dexamethasone" ], "offsets": [ [ 455, 468 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T29", "type": "Scope", "text": [ "rituximab, cyclophosphamide, vincristine sulfate, doxorubicin hydrochloride, dexamethasone" ], "offsets": [ [ 378, 468 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T6", "type": "Drug", "text": [ "rituximab" ], "offsets": [ [ 91, 100 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T30", "type": "Drug", "text": [ "anthracycline" ], "offsets": [ [ 105, 118 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T31", "type": "Scope", "text": [ "R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone), R-EPOCH (rituximab, etoposide phosphate, prednisone, vincristine sulfate, cyclophosphamide, doxorubicin hydrochloride), R-HyperCVAD (rituximab, cyclophosphamide, vincristine sulfate, doxorubicin hydrochloride, dexamethasone) etc" ], "offsets": [ [ 165, 473 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T32", "type": "Temporal", "text": [ "after" ], "offsets": [ [ 79, 84 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T33", "type": "Reference_point", "text": [ "prior rituximab and anthracycline-containing systemic treatment regimen" ], "offsets": [ [ 85, 156 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T34", "type": "Multiplier", "text": [ "no more than 2" ], "offsets": [ [ 504, 518 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T35", "type": "Temporal", "text": [ "prior" ], "offsets": [ [ 519, 524 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T36", "type": "Procedure", "text": [ "systemic therapies for lymphoma" ], "offsets": [ [ 525, 556 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T37", "type": "Drug", "text": [ "rituximab" ], "offsets": [ [ 586, 595 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T38", "type": "Procedure", "text": [ "systemic", "monotherapy" ], "offsets": [ [ 577, 585 ], [ 596, 607 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T39", "type": "Temporal", "text": [ "Prior" ], "offsets": [ [ 558, 563 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T40", "type": "Procedure", "text": [ "conventional chemotherapy" ], "offsets": [ [ 611, 636 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T41", "type": "Drug", "text": [ "bendamustine" ], "offsets": [ [ 643, 655 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T42", "type": "Drug", "text": [ "CVP" ], "offsets": [ [ 657, 660 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T43", "type": "Drug", "text": [ "Cyclophosphamide" ], "offsets": [ [ 662, 678 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T44", "type": "Drug", "text": [ "Vincristine Sulfate" ], "offsets": [ [ 680, 699 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T45", "type": "Drug", "text": [ "Prednisone" ], "offsets": [ [ 701, 711 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T46", "type": "Scope", "text": [ "Cyclophosphamide, Vincristine Sulfate, Prednisone" ], "offsets": [ [ 662, 711 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T47", "type": "Drug", "text": [ "rituximab" ], "offsets": [ [ 725, 734 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T48", "type": "Condition", "text": [ "non-Hodgkin's lymphoma (NHL)" ], "offsets": [ [ 748, 776 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T49", "type": "Qualifier", "text": [ "indolent" ], "offsets": [ [ 739, 747 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T50", "type": "Drug", "text": [ "rituximab" ], "offsets": [ [ 804, 813 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T51", "type": "Scope", "text": [ "bendamustine, CVP (Cyclophosphamide, Vincristine Sulfate, Prednisone) or other" ], "offsets": [ [ 643, 721 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T52", "type": "Qualifier", "text": [ "maintenance" ], "offsets": [ [ 779, 790 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T53", "type": "Qualifier", "text": [ "extended-use" ], "offsets": [ [ 791, 803 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T54", "type": "Scope", "text": [ "maintenance/extended-use" ], "offsets": [ [ 779, 803 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T55", "type": "Measurement", "text": [ "Eastern Cooperative Oncology Group (ECOG) Performance status" ], "offsets": [ [ 857, 917 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T56", "type": "Value", "text": [ "≤ 2" ], "offsets": [ [ 918, 921 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T57", "type": "Condition", "text": [ "normal organ", "function" ], "offsets": [ [ 942, 954 ], [ 966, 974 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T58", "type": "Condition", "text": [ "normal", "marrow function" ], "offsets": [ [ 942, 948 ], [ 959, 974 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T59", "type": "Scope", "text": [ "Subjects must have normal organ and marrow function as defined below:" ], "offsets": [ [ 923, 992 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T60", "type": "Measurement", "text": [ "Hemoglobin" ], "offsets": [ [ 994, 1004 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T61", "type": "Value", "text": [ "≥ 8.0 g/dl" ], "offsets": [ [ 1005, 1015 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T62", "type": "Measurement", "text": [ "Absolute neutrophil count" ], "offsets": [ [ 1017, 1042 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T63", "type": "Value", "text": [ "≥ 1,000/mcL" ], "offsets": [ [ 1043, 1054 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T64", "type": "Measurement", "text": [ "Platelet count" ], "offsets": [ [ 1056, 1070 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T65", "type": "Value", "text": [ "≥ 75,000/mcL" ], "offsets": [ [ 1071, 1083 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T66", "type": "Measurement", "text": [ "Total bilirubin" ], "offsets": [ [ 1085, 1100 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T67", "type": "Value", "text": [ "≤ 1.5 X the upper limit of normal (ULN)" ], "offsets": [ [ 1101, 1140 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T68", "type": "Condition", "text": [ "impaired bilirubin conjugation" ], "offsets": [ [ 1167, 1197 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T69", "type": "Condition", "text": [ "Gilbert's" ], "offsets": [ [ 1206, 1215 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T70", "type": "Value", "text": [ "maximum", "2.5 ULN" ], "offsets": [ [ 1230, 1237 ], [ 1246, 1253 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T71", "type": "Scope", "text": [ "≤ 1.5 X the upper limit of normal (ULN) unless a known history of impaired bilirubin conjugation such as Gilbert's, for whom the maximum will be 2.5 ULN" ], "offsets": [ [ 1101, 1253 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T72", "type": "Measurement", "text": [ "Aspartate transaminase (AST) (SGOT)" ], "offsets": [ [ 1256, 1291 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T73", "type": "Value", "text": [ "≤ 2.5 X institutional ULN" ], "offsets": [ [ 1292, 1317 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T74", "type": "Measurement", "text": [ "Alanine transaminase (ALT) (SGPT)" ], "offsets": [ [ 1319, 1352 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T75", "type": "Value", "text": [ "≤ 2.5 X institutional ULN" ], "offsets": [ [ 1353, 1378 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T76", "type": "Measurement", "text": [ "International normalized ratio (INR)" ], "offsets": [ [ 1380, 1416 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T77", "type": "Value", "text": [ "> 1.5 ×ULN" ], "offsets": [ [ 1417, 1427 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T78", "type": "Measurement", "text": [ "serum creatinine clearance" ], "offsets": [ [ 1461, 1487 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T79", "type": "Value", "text": [ "> 50 mL/min" ], "offsets": [ [ 1488, 1499 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T80", "type": "Qualifier", "text": [ "Cockcroft-Gault calculation" ], "offsets": [ [ 1506, 1533 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T81", "type": "Qualifier", "text": [ "24-hour urine collection" ], "offsets": [ [ 1546, 1570 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T82", "type": "Temporal", "text": [ "within 7 days prior" ], "offsets": [ [ 1581, 1600 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T83", "type": "Reference_point", "text": [ "treatment" ], "offsets": [ [ 1604, 1613 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T84", "type": "Scope", "text": [ "Cockcroft-Gault calculation or based on 24-hour urine collection" ], "offsets": [ [ 1506, 1570 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T86", "type": "Measurement", "text": [ "HBsAg" ], "offsets": [ [ 1755, 1760 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T87", "type": "Value", "text": [ "negative" ], "offsets": [ [ 1761, 1769 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T88", "type": "Measurement", "text": [ "HBcAb" ], "offsets": [ [ 1771, 1776 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T89", "type": "Value", "text": [ "negative" ], "offsets": [ [ 1777, 1785 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T90", "type": "Measurement", "text": [ "HBsAb" ], "offsets": [ [ 1787, 1792 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T91", "type": "Value", "text": [ "positive" ], "offsets": [ [ 1793, 1801 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T92", "type": "Measurement", "text": [ "HBsAg" ], "offsets": [ [ 1857, 1862 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T93", "type": "Value", "text": [ "positive" ], "offsets": [ [ 1844, 1852 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T95", "type": "Measurement", "text": [ "HBsAg" ], "offsets": [ [ 1893, 1898 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T96", "type": "Value", "text": [ "negative" ], "offsets": [ [ 1899, 1907 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T97", "type": "Measurement", "text": [ "HBcAb" ], "offsets": [ [ 1913, 1918 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T98", "type": "Value", "text": [ "positive" ], "offsets": [ [ 1919, 1927 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T99", "type": "Procedure", "text": [ "HBV DNA testing" ], "offsets": [ [ 1971, 1986 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T101", "type": "Measurement", "text": [ "HBV DNA" ], "offsets": [ [ 2048, 2055 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T102", "type": "Value", "text": [ "positive" ], "offsets": [ [ 2059, 2067 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T104", "type": "Measurement", "text": [ "HBV DNA" ], "offsets": [ [ 2100, 2107 ] ], "normalized": [] }, { "id": "NCT03064867_inc_T105", "type": "Value", "text": [ "negative" ], "offsets": [ [ 2111, 2119 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03064867_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03064867_inc_T3", "arg2_id": "NCT03064867_inc_T4", "normalized": [] }, { "id": "NCT03064867_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03064867_inc_T3", "arg2_id": "NCT03064867_inc_T5", "normalized": [] }, { "id": "NCT03064867_inc_R3", "type": "Subsumes", "arg1_id": "NCT03064867_inc_T8", "arg2_id": "NCT03064867_inc_T14", "normalized": [] }, { "id": "NCT03064867_inc_R4", "type": "Subsumes", "arg1_id": "NCT03064867_inc_T15", "arg2_id": "NCT03064867_inc_T22", "normalized": [] }, { "id": "NCT03064867_inc_R5", "type": "Has_scope", "arg1_id": "NCT03064867_inc_T23", "arg2_id": "NCT03064867_inc_T29", "normalized": [] }, { "id": "NCT03064867_inc_R6", "type": "Has_value", "arg1_id": "NCT03064867_inc_T1", "arg2_id": "NCT03064867_inc_T2", "normalized": [] }, { "id": "NCT03064867_inc_R7", "type": "Subsumes", "arg1_id": "NCT03064867_inc_T7", "arg2_id": "NCT03064867_inc_T31", "normalized": [] }, { "id": "NCT03064867_inc_R8", "type": "Has_index", "arg1_id": "NCT03064867_inc_T32", "arg2_id": "NCT03064867_inc_T33", "normalized": [] }, { "id": "NCT03064867_inc_R9", "type": "Has_temporal", "arg1_id": "NCT03064867_inc_T1", "arg2_id": "NCT03064867_inc_T32", "normalized": [] }, { "id": "NCT03064867_inc_R10", "type": "AND", "arg1_id": "NCT03064867_inc_T1", "arg2_id": "NCT03064867_inc_T3", "normalized": [] }, { "id": "NCT03064867_inc_R11", "type": "Has_temporal", "arg1_id": "NCT03064867_inc_T36", "arg2_id": "NCT03064867_inc_T35", "normalized": [] }, { "id": "NCT03064867_inc_R12", "type": "Has_multiplier", "arg1_id": "NCT03064867_inc_T36", "arg2_id": "NCT03064867_inc_T34", "normalized": [] }, { "id": "NCT03064867_inc_R13", "type": "AND", "arg1_id": "NCT03064867_inc_T38", "arg2_id": "NCT03064867_inc_T37", "normalized": [] }, { "id": "NCT03064867_inc_R14", "type": "Subsumes", "arg1_id": "NCT03064867_inc_T42", "arg2_id": "NCT03064867_inc_T46", "normalized": [] }, { "id": "NCT03064867_inc_R15", "type": "Has_qualifier", "arg1_id": "NCT03064867_inc_T48", "arg2_id": "NCT03064867_inc_T49", "normalized": [] }, { "id": "NCT03064867_inc_R16", "type": "Subsumes", "arg1_id": "NCT03064867_inc_T40", "arg2_id": "NCT03064867_inc_T51", "normalized": [] }, { "id": "NCT03064867_inc_R17", "type": "AND", "arg1_id": "NCT03064867_inc_T47", "arg2_id": "NCT03064867_inc_T48", "normalized": [] }, { "id": "NCT03064867_inc_R18", "type": "Has_scope", "arg1_id": "NCT03064867_inc_T50", "arg2_id": "NCT03064867_inc_T54", "normalized": [] }, { "id": "NCT03064867_inc_R19", "type": "Has_value", "arg1_id": "NCT03064867_inc_T55", "arg2_id": "NCT03064867_inc_T56", "normalized": [] }, { "id": "NCT03064867_inc_R20", "type": "Has_value", "arg1_id": "NCT03064867_inc_T60", "arg2_id": "NCT03064867_inc_T61", "normalized": [] }, { "id": "NCT03064867_inc_R21", "type": "Has_value", "arg1_id": "NCT03064867_inc_T62", "arg2_id": "NCT03064867_inc_T63", "normalized": [] }, { "id": "NCT03064867_inc_R22", "type": "Has_value", "arg1_id": "NCT03064867_inc_T64", "arg2_id": "NCT03064867_inc_T65", "normalized": [] }, { "id": "NCT03064867_inc_R24", "type": "Subsumes", "arg1_id": "NCT03064867_inc_T68", "arg2_id": "NCT03064867_inc_T69", "normalized": [] }, { "id": "NCT03064867_inc_R23", "type": "AND", "arg1_id": "NCT03064867_inc_T70", "arg2_id": "NCT03064867_inc_T68", "normalized": [] }, { "id": "NCT03064867_inc_R25", "type": "Has_scope", "arg1_id": "NCT03064867_inc_T66", "arg2_id": "NCT03064867_inc_T71", "normalized": [] }, { "id": "NCT03064867_inc_R26", "type": "Has_value", "arg1_id": "NCT03064867_inc_T72", "arg2_id": "NCT03064867_inc_T73", "normalized": [] }, { "id": "NCT03064867_inc_R27", "type": "Has_value", "arg1_id": "NCT03064867_inc_T74", "arg2_id": "NCT03064867_inc_T75", "normalized": [] }, { "id": "NCT03064867_inc_R28", "type": "Has_value", "arg1_id": "NCT03064867_inc_T76", "arg2_id": "NCT03064867_inc_T77", "normalized": [] }, { "id": "NCT03064867_inc_R29", "type": "Has_value", "arg1_id": "NCT03064867_inc_T78", "arg2_id": "NCT03064867_inc_T79", "normalized": [] }, { "id": "NCT03064867_inc_R30", "type": "Has_index", "arg1_id": "NCT03064867_inc_T82", "arg2_id": "NCT03064867_inc_T83", "normalized": [] }, { "id": "NCT03064867_inc_R31", "type": "Has_scope", "arg1_id": "NCT03064867_inc_T78", "arg2_id": "NCT03064867_inc_T84", "normalized": [] }, { "id": "NCT03064867_inc_R32", "type": "Has_temporal", "arg1_id": "NCT03064867_inc_T78", "arg2_id": "NCT03064867_inc_T82", "normalized": [] }, { "id": "NCT03064867_inc_R33", "type": "Has_value", "arg1_id": "NCT03064867_inc_T86", "arg2_id": "NCT03064867_inc_T87", "normalized": [] }, { "id": "NCT03064867_inc_R34", "type": "Has_value", "arg1_id": "NCT03064867_inc_T88", "arg2_id": "NCT03064867_inc_T89", "normalized": [] }, { "id": "NCT03064867_inc_R35", "type": "Has_value", "arg1_id": "NCT03064867_inc_T90", "arg2_id": "NCT03064867_inc_T91", "normalized": [] }, { "id": "NCT03064867_inc_R36", "type": "Has_value", "arg1_id": "NCT03064867_inc_T92", "arg2_id": "NCT03064867_inc_T93", "normalized": [] }, { "id": "NCT03064867_inc_R37", "type": "Has_value", "arg1_id": "NCT03064867_inc_T95", "arg2_id": "NCT03064867_inc_T96", "normalized": [] }, { "id": "NCT03064867_inc_R38", "type": "Has_value", "arg1_id": "NCT03064867_inc_T97", "arg2_id": "NCT03064867_inc_T98", "normalized": [] }, { "id": "NCT03064867_inc_R39", "type": "Has_value", "arg1_id": "NCT03064867_inc_T101", "arg2_id": "NCT03064867_inc_T102", "normalized": [] }, { "id": "NCT03064867_inc_R40", "type": "Has_value", "arg1_id": "NCT03064867_inc_T104", "arg2_id": "NCT03064867_inc_T105", "normalized": [] } ]