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BigScience Biomedical Datasets 131

[ { "id": "NCT02920177_exc_text", "type": "exclusion", "text": [ "Established Osteoarthritis (Kellgren-Lawrence > 3)\nMinimum joint space > 2 mm as measured on AP radiograph\nHip dysplasia (center edge angle < 20° on AP radiograph)\nPatients with clinically significant cardiovascular, renal, hepatic, endocrine disease, cancer or diabetes\nPatients with ongoing infection including HIV and Hepatitis\nPatient with history of osteomyelitis/septic arthritis\nAnticoagulation therapy\nPatients who are pregnant or breast feeding\nPatients with systemic, rheumatic or inflammatory disease of the knee or chondrocalcinosis, hemochromatosis, inflammatory arthritis, arthropathy of the knee associated with juxta-articular Paget's disease of the femur or tibia, hemophilic arthropathy, infectious arthritis, Charcot's knee joint, villonodular synovitis, and synovial chondromatosis\nPatients taking immunosuppressant medication\nPatients with abnormal hematology or serum chemistry lab results\nPatients receiving injection to treatment knee within 2 months of study enrollment\nBMI greater than 35 or less than 20\n" ], "offsets": [ [ 0, 1031 ] ] } ]

[ { "id": "NCT02920177_exc_T1", "type": "Condition", "text": [ "Osteoarthritis" ], "offsets": [ [ 12, 26 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T2", "type": "Measurement", "text": [ "Kellgren-Lawrence" ], "offsets": [ [ 28, 45 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T3", "type": "Value", "text": [ "> 3" ], "offsets": [ [ 46, 49 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T4", "type": "Measurement", "text": [ "Minimum joint space" ], "offsets": [ [ 51, 70 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T5", "type": "Value", "text": [ "> 2 mm" ], "offsets": [ [ 71, 77 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T6", "type": "Procedure", "text": [ "AP radiograph" ], "offsets": [ [ 93, 106 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T7", "type": "Condition", "text": [ "Hip dysplasia" ], "offsets": [ [ 107, 120 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T8", "type": "Measurement", "text": [ "center edge angle" ], "offsets": [ [ 122, 139 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T9", "type": "Value", "text": [ "< 20°" ], "offsets": [ [ 140, 145 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T10", "type": "Procedure", "text": [ "AP radiograph" ], "offsets": [ [ 149, 162 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T11", "type": "Condition", "text": [ "diovascular, r", "ease, c" ], "offsets": [ [ 204, 218 ], [ 246, 253 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T12", "type": "Condition", "text": [ "al, h", "ease, c" ], "offsets": [ [ 220, 225 ], [ 246, 253 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T13", "type": "Condition", "text": [ "atic, e", "ease, c" ], "offsets": [ [ 227, 234 ], [ 246, 253 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T14", "type": "Condition", "text": [ "endocrine disease" ], "offsets": [ [ 233, 250 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T15", "type": "Condition", "text": [ "cancer" ], "offsets": [ [ 252, 258 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T16", "type": "Condition", "text": [ "diabetes" ], "offsets": [ [ 262, 270 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T17", "type": "Qualifier", "text": [ "significant" ], "offsets": [ [ 189, 200 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T18", "type": "Scope", "text": [ "cardiovascular, renal, hepatic, endocrine disease, cancer or diabetes" ], "offsets": [ [ 201, 270 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T19", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 293, 302 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T20", "type": "Qualifier", "text": [ "ongoing" ], "offsets": [ [ 285, 292 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T21", "type": "Condition", "text": [ "HIV" ], "offsets": [ [ 313, 316 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T22", "type": "Condition", "text": [ "Hepatitis" ], "offsets": [ [ 321, 330 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T24", "type": "Scope", "text": [ "HIV and Hepatitis" ], "offsets": [ [ 313, 330 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T25", "type": "Condition", "text": [ "septic arthritis" ], "offsets": [ [ 369, 385 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T26", "type": "Condition", "text": [ "osteomyelitis" ], "offsets": [ [ 355, 368 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T28", "type": "Procedure", "text": [ "Anticoagulation therapy" ], "offsets": [ [ 386, 409 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T30", "type": "Condition", "text": [ "chondrocalcinosis" ], "offsets": [ [ 527, 544 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T31", "type": "Condition", "text": [ "hemochromatosis" ], "offsets": [ [ 546, 561 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T32", "type": "Condition", "text": [ "inflammatory arthritis" ], "offsets": [ [ 563, 585 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T33", "type": "Condition", "text": [ "arthropathy of the knee" ], "offsets": [ [ 587, 610 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T34", "type": "Condition", "text": [ "Paget's disease" ], "offsets": [ [ 643, 658 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T35", "type": "Condition", "text": [ "hemophilic arthropathy" ], "offsets": [ [ 682, 704 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T36", "type": "Condition", "text": [ "infectious arthritis" ], "offsets": [ [ 706, 726 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T37", "type": "Condition", "text": [ "Charcot's knee joint" ], "offsets": [ [ 728, 748 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T38", "type": "Condition", "text": [ "villonodular synovitis" ], "offsets": [ [ 750, 772 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T39", "type": "Condition", "text": [ "synovial chondromatosis" ], "offsets": [ [ 778, 801 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T41", "type": "Qualifier", "text": [ "femur" ], "offsets": [ [ 666, 671 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T42", "type": "Qualifier", "text": [ "tibia" ], "offsets": [ [ 675, 680 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T43", "type": "Qualifier", "text": [ "juxta-articular" ], "offsets": [ [ 627, 642 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T44", "type": "Qualifier", "text": [ "knee" ], "offsets": [ [ 519, 523 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T45", "type": "Condition", "text": [ "inflammatory disease" ], "offsets": [ [ 491, 511 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T46", "type": "Condition", "text": [ "c or infl", "of the" ], "offsets": [ [ 486, 495 ], [ 512, 518 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T47", "type": "Condition", "text": [ ", rheuma", "of the" ], "offsets": [ [ 476, 484 ], [ 512, 518 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T48", "type": "Scope", "text": [ "systemic, rheumatic or inflammatory disease" ], "offsets": [ [ 468, 511 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T49", "type": "Scope", "text": [ "femur or tibia" ], "offsets": [ [ 666, 680 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T50", "type": "Scope", "text": [ "arthropathy of the knee associated with juxta-articular Paget's disease of the femur or tibia" ], "offsets": [ [ 587, 680 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T51", "type": "Procedure", "text": [ "immunosuppressant medication" ], "offsets": [ [ 818, 846 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T52", "type": "Measurement", "text": [ "serum chemistry lab" ], "offsets": [ [ 884, 903 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T53", "type": "Measurement", "text": [ " or seru", "s\nP" ], "offsets": [ [ 880, 888 ], [ 910, 913 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T54", "type": "Value", "text": [ "abnormal" ], "offsets": [ [ 861, 869 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T55", "type": "Scope", "text": [ "hematology or serum chemistry lab" ], "offsets": [ [ 870, 903 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T56", "type": "Procedure", "text": [ "injection" ], "offsets": [ [ 931, 940 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T57", "type": "Qualifier", "text": [ "knee" ], "offsets": [ [ 954, 958 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T58", "type": "Temporal", "text": [ "within 2 months of study enrollment" ], "offsets": [ [ 959, 994 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T59", "type": "Reference_point", "text": [ "study enrollment" ], "offsets": [ [ 978, 994 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T60", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 995, 998 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T61", "type": "Value", "text": [ "greater than 35" ], "offsets": [ [ 999, 1014 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T62", "type": "Value", "text": [ "less than 20" ], "offsets": [ [ 1018, 1030 ] ], "normalized": [] }, { "id": "NCT02920177_exc_T63", "type": "Scope", "text": [ "greater than 35 or less than 20" ], "offsets": [ [ 999, 1030 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02920177_exc_R1", "type": "Has_value", "arg1_id": "NCT02920177_exc_T2", "arg2_id": "NCT02920177_exc_T3", "normalized": [] }, { "id": "NCT02920177_exc_R2", "type": "Has_value", "arg1_id": "NCT02920177_exc_T4", "arg2_id": "NCT02920177_exc_T5", "normalized": [] }, { "id": "NCT02920177_exc_R3", "type": "Has_value", "arg1_id": "NCT02920177_exc_T8", "arg2_id": "NCT02920177_exc_T9", "normalized": [] }, { "id": "NCT02920177_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT02920177_exc_T18", "arg2_id": "NCT02920177_exc_T17", "normalized": [] }, { "id": "NCT02920177_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02920177_exc_T19", "arg2_id": "NCT02920177_exc_T20", "normalized": [] }, { "id": "NCT02920177_exc_R6", "type": "Subsumes", "arg1_id": "NCT02920177_exc_T19", "arg2_id": "NCT02920177_exc_T24", "normalized": [] }, { "id": "NCT02920177_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT02920177_exc_T48", "arg2_id": "NCT02920177_exc_T44", "normalized": [] }, { "id": "NCT02920177_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT02920177_exc_T34", "arg2_id": "NCT02920177_exc_T43", "normalized": [] }, { "id": "NCT02920177_exc_R9", "type": "Has_scope", "arg1_id": "NCT02920177_exc_T34", "arg2_id": "NCT02920177_exc_T49", "normalized": [] }, { "id": "NCT02920177_exc_R10", "type": "Has_value", "arg1_id": "NCT02920177_exc_T55", "arg2_id": "NCT02920177_exc_T54", "normalized": [] }, { "id": "NCT02920177_exc_R11", "type": "Has_index", "arg1_id": "NCT02920177_exc_T58", "arg2_id": "NCT02920177_exc_T59", "normalized": [] }, { "id": "NCT02920177_exc_R12", "type": "Has_qualifier", "arg1_id": "NCT02920177_exc_T56", "arg2_id": "NCT02920177_exc_T57", "normalized": [] }, { "id": "NCT02920177_exc_R13", "type": "Has_scope", "arg1_id": "NCT02920177_exc_T60", "arg2_id": "NCT02920177_exc_T63", "normalized": [] } ]

[ { "id": "NCT02920177_inc_text", "type": "inclusion", "text": [ "Patients with symptomatic FAI\nClinical and radiographic evidence of FAI\nPatients able to provide consent to study participation\nCompletion of 6 weeks of physical therapy program\n" ], "offsets": [ [ 0, 178 ] ] } ]

[ { "id": "NCT02920177_inc_T1", "type": "Condition", "text": [ "FAI" ], "offsets": [ [ 26, 29 ] ], "normalized": [] }, { "id": "NCT02920177_inc_T2", "type": "Qualifier", "text": [ "symptomatic" ], "offsets": [ [ 14, 25 ] ], "normalized": [] }, { "id": "NCT02920177_inc_T3", "type": "Condition", "text": [ "FAI" ], "offsets": [ [ 68, 71 ] ], "normalized": [] }, { "id": "NCT02920177_inc_T4", "type": "Qualifier", "text": [ "radiographic evidence" ], "offsets": [ [ 43, 64 ] ], "normalized": [] }, { "id": "NCT02920177_inc_T5", "type": "Qualifier", "text": [ "linical", "vidence" ], "offsets": [ [ 31, 38 ], [ 57, 64 ] ], "normalized": [] }, { "id": "NCT02920177_inc_T6", "type": "Scope", "text": [ "Clinical and radiographic evidence" ], "offsets": [ [ 30, 64 ] ], "normalized": [] }, { "id": "NCT02920177_inc_T8", "type": "Procedure", "text": [ "physical therapy program" ], "offsets": [ [ 153, 177 ] ], "normalized": [] }, { "id": "NCT02920177_inc_T9", "type": "Temporal", "text": [ "6 weeks" ], "offsets": [ [ 142, 149 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02920177_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT02920177_inc_T1", "arg2_id": "NCT02920177_inc_T2", "normalized": [] }, { "id": "NCT02920177_inc_R2", "type": "Has_scope", "arg1_id": "NCT02920177_inc_T3", "arg2_id": "NCT02920177_inc_T6", "normalized": [] }, { "id": "NCT02920177_inc_R3", "type": "Has_temporal", "arg1_id": "NCT02920177_inc_T8", "arg2_id": "NCT02920177_inc_T9", "normalized": [] } ]

[ { "id": "NCT02923700_exc_text", "type": "exclusion", "text": [ "age > 80 years;\nKellgren-Lawrence score at X-ray evaluation > 3;\nmajor axial deviation (varus >5° , valgus > 5°),\nsystemic disorders such as diabetes, rheumatoid arthritis, haematological diseases (coagulopathy), severe cardiovascular diseases, infections, immunodepression;\npatients in therapy with anticoagulants or antiaggregants;\nuse of NSAIDs in the 5 days before blood donation;\npatients with Hb values < 11 g/dl and platelet values < 150,000/mmc.\n" ], "offsets": [ [ 0, 454 ] ] } ]

[ { "id": "NCT02923700_exc_T1", "type": "Person", "text": [ "age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T2", "type": "Value", "text": [ "> 80 years" ], "offsets": [ [ 4, 14 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T3", "type": "Measurement", "text": [ "Kellgren-Lawrence score" ], "offsets": [ [ 16, 39 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T4", "type": "Procedure", "text": [ "X-ray evaluation" ], "offsets": [ [ 43, 59 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T5", "type": "Value", "text": [ "> 3" ], "offsets": [ [ 60, 63 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T6", "type": "Condition", "text": [ "major axial deviation" ], "offsets": [ [ 65, 86 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T7", "type": "Measurement", "text": [ "varus" ], "offsets": [ [ 88, 93 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T8", "type": "Measurement", "text": [ "valgus" ], "offsets": [ [ 100, 106 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T9", "type": "Value", "text": [ ">5°" ], "offsets": [ [ 94, 97 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T10", "type": "Value", "text": [ "> 5°" ], "offsets": [ [ 107, 111 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T11", "type": "Scope", "text": [ "varus >5° , valgus > 5°" ], "offsets": [ [ 88, 111 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T12", "type": "Condition", "text": [ "systemic disorders" ], "offsets": [ [ 114, 132 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T13", "type": "Condition", "text": [ "diabetes" ], "offsets": [ [ 141, 149 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T14", "type": "Condition", "text": [ "rheumatoid arthritis" ], "offsets": [ [ 151, 171 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T15", "type": "Condition", "text": [ "haematological diseases" ], "offsets": [ [ 173, 196 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T16", "type": "Condition", "text": [ "coagulopathy" ], "offsets": [ [ 198, 210 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T17", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 213, 219 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T18", "type": "Condition", "text": [ "cardiovascular diseases" ], "offsets": [ [ 220, 243 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T19", "type": "Condition", "text": [ "infections" ], "offsets": [ [ 245, 255 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T20", "type": "Condition", "text": [ "immunodepression" ], "offsets": [ [ 257, 273 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T21", "type": "Scope", "text": [ "diabetes, rheumatoid arthritis, haematological diseases (coagulopathy), severe cardiovascular diseases, infections, immunodepression" ], "offsets": [ [ 141, 273 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T22", "type": "Drug", "text": [ "anticoagulants" ], "offsets": [ [ 300, 314 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T23", "type": "Drug", "text": [ "antiaggregants" ], "offsets": [ [ 318, 332 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T24", "type": "Procedure", "text": [ "therapy" ], "offsets": [ [ 287, 294 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T25", "type": "Scope", "text": [ "anticoagulants or antiaggregants" ], "offsets": [ [ 300, 332 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T26", "type": "Drug", "text": [ "NSAIDs" ], "offsets": [ [ 341, 347 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T27", "type": "Temporal", "text": [ "in the 5 days before blood donation" ], "offsets": [ [ 348, 383 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T28", "type": "Measurement", "text": [ "Hb" ], "offsets": [ [ 399, 401 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T29", "type": "Value", "text": [ "< 11 g/dl" ], "offsets": [ [ 409, 418 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T30", "type": "Measurement", "text": [ "platelet" ], "offsets": [ [ 423, 431 ] ], "normalized": [] }, { "id": "NCT02923700_exc_T31", "type": "Value", "text": [ "< 150,000/mmc" ], "offsets": [ [ 439, 452 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02923700_exc_R1", "type": "Has_value", "arg1_id": "NCT02923700_exc_T1", "arg2_id": "NCT02923700_exc_T2", "normalized": [] }, { "id": "NCT02923700_exc_R2", "type": "AND", "arg1_id": "NCT02923700_exc_T4", "arg2_id": "NCT02923700_exc_T3", "normalized": [] }, { "id": "NCT02923700_exc_R3", "type": "Has_value", "arg1_id": "NCT02923700_exc_T3", "arg2_id": "NCT02923700_exc_T5", "normalized": [] }, { "id": "NCT02923700_exc_R4", "type": "Has_value", "arg1_id": "NCT02923700_exc_T8", "arg2_id": "NCT02923700_exc_T10", "normalized": [] }, { "id": "NCT02923700_exc_R5", "type": "Has_value", "arg1_id": "NCT02923700_exc_T7", "arg2_id": "NCT02923700_exc_T9", "normalized": [] }, { "id": "NCT02923700_exc_R6", "type": "Subsumes", "arg1_id": "NCT02923700_exc_T6", "arg2_id": "NCT02923700_exc_T11", "normalized": [] }, { "id": "NCT02923700_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT02923700_exc_T18", "arg2_id": "NCT02923700_exc_T17", "normalized": [] }, { "id": "NCT02923700_exc_R8", "type": "Subsumes", "arg1_id": "NCT02923700_exc_T15", "arg2_id": "NCT02923700_exc_T16", "normalized": [] }, { "id": "NCT02923700_exc_R9", "type": "Subsumes", "arg1_id": "NCT02923700_exc_T12", "arg2_id": "NCT02923700_exc_T21", "normalized": [] }, { "id": "NCT02923700_exc_R10", "type": "Has_scope", "arg1_id": "NCT02923700_exc_T24", "arg2_id": "NCT02923700_exc_T25", "normalized": [] }, { "id": "NCT02923700_exc_R11", "type": "Has_temporal", "arg1_id": "NCT02923700_exc_T26", "arg2_id": "NCT02923700_exc_T27", "normalized": [] }, { "id": "NCT02923700_exc_R12", "type": "Has_value", "arg1_id": "NCT02923700_exc_T28", "arg2_id": "NCT02923700_exc_T29", "normalized": [] }, { "id": "NCT02923700_exc_R13", "type": "Has_value", "arg1_id": "NCT02923700_exc_T30", "arg2_id": "NCT02923700_exc_T31", "normalized": [] } ]

[ { "id": "NCT02923700_inc_text", "type": "inclusion", "text": [ "patients affected by mono-lateral symptomatic knee articular degenerative pathology with history of chronic (for at least 4 months) pain or swelling;\nimaging findings of degenerative changes of the joint (osteoarthritis or chondropathy with Kellgren Lawrence Score from 0 to 3 at X-ray evaluation).\n" ], "offsets": [ [ 0, 299 ] ] } ]

[ { "id": "NCT02923700_inc_T1", "type": "Qualifier", "text": [ "mono-lateral" ], "offsets": [ [ 21, 33 ] ], "normalized": [] }, { "id": "NCT02923700_inc_T2", "type": "Qualifier", "text": [ "symptomatic" ], "offsets": [ [ 34, 45 ] ], "normalized": [] }, { "id": "NCT02923700_inc_T3", "type": "Condition", "text": [ "knee articular degenerative pathology" ], "offsets": [ [ 46, 83 ] ], "normalized": [] }, { "id": "NCT02923700_inc_T4", "type": "Condition", "text": [ "pain" ], "offsets": [ [ 132, 136 ] ], "normalized": [] }, { "id": "NCT02923700_inc_T5", "type": "Condition", "text": [ "swelling" ], "offsets": [ [ 140, 148 ] ], "normalized": [] }, { "id": "NCT02923700_inc_T6", "type": "Temporal", "text": [ "chronic" ], "offsets": [ [ 100, 107 ] ], "normalized": [] }, { "id": "NCT02923700_inc_T7", "type": "Temporal", "text": [ "for at least 4 months" ], "offsets": [ [ 109, 130 ] ], "normalized": [] }, { "id": "NCT02923700_inc_T8", "type": "Scope", "text": [ "pain or swelling" ], "offsets": [ [ 132, 148 ] ], "normalized": [] }, { "id": "NCT02923700_inc_T9", "type": "Procedure", "text": [ "imaging" ], "offsets": [ [ 150, 157 ] ], "normalized": [] }, { "id": "NCT02923700_inc_T10", "type": "Condition", "text": [ "degenerative changes" ], "offsets": [ [ 170, 190 ] ], "normalized": [] }, { "id": "NCT02923700_inc_T11", "type": "Condition", "text": [ "osteoarthritis" ], "offsets": [ [ 205, 219 ] ], "normalized": [] }, { "id": "NCT02923700_inc_T12", "type": "Condition", "text": [ "chondropathy" ], "offsets": [ [ 223, 235 ] ], "normalized": [] }, { "id": "NCT02923700_inc_T13", "type": "Measurement", "text": [ "Kellgren Lawrence Score" ], "offsets": [ [ 241, 264 ] ], "normalized": [] }, { "id": "NCT02923700_inc_T14", "type": "Value", "text": [ "from 0 to 3" ], "offsets": [ [ 265, 276 ] ], "normalized": [] }, { "id": "NCT02923700_inc_T15", "type": "Procedure", "text": [ "X-ray" ], "offsets": [ [ 280, 285 ] ], "normalized": [] }, { "id": "NCT02923700_inc_T16", "type": "Scope", "text": [ "osteoarthritis or chondropathy" ], "offsets": [ [ 205, 235 ] ], "normalized": [] }, { "id": "NCT02923700_inc_T17", "type": "Scope", "text": [ "osteoarthritis or chondropathy with Kellgren Lawrence Score from 0 to 3 at X-ray" ], "offsets": [ [ 205, 285 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02923700_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT02923700_inc_T3", "arg2_id": "NCT02923700_inc_T2", "normalized": [] }, { "id": "NCT02923700_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02923700_inc_T3", "arg2_id": "NCT02923700_inc_T1", "normalized": [] }, { "id": "NCT02923700_inc_R3", "type": "Subsumes", "arg1_id": "NCT02923700_inc_T6", "arg2_id": "NCT02923700_inc_T7", "normalized": [] }, { "id": "NCT02923700_inc_R4", "type": "Has_temporal", "arg1_id": "NCT02923700_inc_T8", "arg2_id": "NCT02923700_inc_T6", "normalized": [] }, { "id": "NCT02923700_inc_R5", "type": "Has_value", "arg1_id": "NCT02923700_inc_T13", "arg2_id": "NCT02923700_inc_T14", "normalized": [] }, { "id": "NCT02923700_inc_R6", "type": "AND", "arg1_id": "NCT02923700_inc_T15", "arg2_id": "NCT02923700_inc_T13", "normalized": [] }, { "id": "NCT02923700_inc_R7", "type": "Subsumes", "arg1_id": "NCT02923700_inc_T10", "arg2_id": "NCT02923700_inc_T17", "normalized": [] }, { "id": "NCT02923700_inc_R8", "type": "AND", "arg1_id": "NCT02923700_inc_T9", "arg2_id": "NCT02923700_inc_T10", "normalized": [] } ]

[ { "id": "NCT02924090_exc_text", "type": "exclusion", "text": [ "Relative contraindications to ECT therapy (recent MI or CVA, increased intracranial pressure, intracranial mass lesion, intracranial aneurysm, epilepsy, known cardiac arrhythmia, pheochromocytoma, pregnancy)\nContraindications to etomidate (sepsis, primary or secondary adrenal insufficiency, porphyria)\nDSM-V diagnosis of a lifetime history of psychotic spectrum disorder\nDrug or alcohol dependence, or abuse within the past 3 months, soy-bean oil allergy\n" ], "offsets": [ [ 0, 456 ] ] } ]

[ { "id": "NCT02924090_exc_T1", "type": "Condition", "text": [ "Relative contraindications" ], "offsets": [ [ 0, 26 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T2", "type": "Procedure", "text": [ "ECT therapy" ], "offsets": [ [ 30, 41 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T3", "type": "Temporal", "text": [ "recent" ], "offsets": [ [ 43, 49 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T4", "type": "Condition", "text": [ "MI" ], "offsets": [ [ 50, 52 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T5", "type": "Condition", "text": [ "CVA" ], "offsets": [ [ 56, 59 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T6", "type": "Scope", "text": [ "MI or CVA" ], "offsets": [ [ 50, 59 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T7", "type": "Value", "text": [ "increased" ], "offsets": [ [ 61, 70 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T8", "type": "Measurement", "text": [ "intracranial pressure" ], "offsets": [ [ 71, 92 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T9", "type": "Condition", "text": [ "intracranial mass lesion" ], "offsets": [ [ 94, 118 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T10", "type": "Condition", "text": [ "intracranial aneurysm" ], "offsets": [ [ 120, 141 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T11", "type": "Condition", "text": [ "epilepsy" ], "offsets": [ [ 143, 151 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T12", "type": "Condition", "text": [ "cardiac arrhythmia" ], "offsets": [ [ 159, 177 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T13", "type": "Condition", "text": [ "pheochromocytoma" ], "offsets": [ [ 179, 195 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T14", "type": "Condition", "text": [ "pregnancy" ], "offsets": [ [ 197, 206 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T15", "type": "Scope", "text": [ "recent MI or CVA, increased intracranial pressure, intracranial mass lesion, intracranial aneurysm, epilepsy, known cardiac arrhythmia, pheochromocytoma, pregnancy" ], "offsets": [ [ 43, 206 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T16", "type": "Scope", "text": [ "Relative contraindications to ECT therapy" ], "offsets": [ [ 0, 41 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T17", "type": "Condition", "text": [ "Contraindications" ], "offsets": [ [ 208, 225 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T18", "type": "Drug", "text": [ "etomidate" ], "offsets": [ [ 229, 238 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T19", "type": "Condition", "text": [ "sepsis" ], "offsets": [ [ 240, 246 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T20", "type": "Qualifier", "text": [ "primary" ], "offsets": [ [ 248, 255 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T21", "type": "Qualifier", "text": [ "secondary" ], "offsets": [ [ 259, 268 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T22", "type": "Condition", "text": [ "adrenal insufficiency" ], "offsets": [ [ 269, 290 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T23", "type": "Condition", "text": [ "porphyria" ], "offsets": [ [ 292, 301 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T24", "type": "Qualifier", "text": [ "DSM-V" ], "offsets": [ [ 303, 308 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T25", "type": "Observation", "text": [ "lifetime history" ], "offsets": [ [ 324, 340 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T26", "type": "Condition", "text": [ "psychotic spectrum disorder" ], "offsets": [ [ 344, 371 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T27", "type": "Condition", "text": [ "g or", "endence, o" ], "offsets": [ [ 375, 379 ], [ 391, 401 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T28", "type": "Condition", "text": [ "alcohol dependence" ], "offsets": [ [ 380, 398 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T29", "type": "Temporal", "text": [ "within the past 3 months" ], "offsets": [ [ 409, 433 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T30", "type": "Condition", "text": [ "g or", "se wi" ], "offsets": [ [ 375, 379 ], [ 406, 411 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T31", "type": "Condition", "text": [ "ohol de", "se wi" ], "offsets": [ [ 383, 390 ], [ 406, 411 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T32", "type": "Scope", "text": [ "Drug or alcohol dependence, or abuse" ], "offsets": [ [ 372, 408 ] ], "normalized": [] }, { "id": "NCT02924090_exc_T33", "type": "Condition", "text": [ "soy-bean oil allergy" ], "offsets": [ [ 435, 455 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02924090_exc_R1", "type": "AND", "arg1_id": "NCT02924090_exc_T1", "arg2_id": "NCT02924090_exc_T2", "normalized": [] }, { "id": "NCT02924090_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02924090_exc_T6", "arg2_id": "NCT02924090_exc_T3", "normalized": [] }, { "id": "NCT02924090_exc_R3", "type": "Has_value", "arg1_id": "NCT02924090_exc_T8", "arg2_id": "NCT02924090_exc_T7", "normalized": [] }, { "id": "NCT02924090_exc_R4", "type": "Subsumes", "arg1_id": "NCT02924090_exc_T16", "arg2_id": "NCT02924090_exc_T15", "normalized": [] }, { "id": "NCT02924090_exc_R5", "type": "AND", "arg1_id": "NCT02924090_exc_T17", "arg2_id": "NCT02924090_exc_T18", "normalized": [] }, { "id": "NCT02924090_exc_R6", "type": "Has_temporal", "arg1_id": "NCT02924090_exc_T26", "arg2_id": "NCT02924090_exc_T25", "normalized": [] }, { "id": "NCT02924090_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT02924090_exc_T26", "arg2_id": "NCT02924090_exc_T24", "normalized": [] }, { "id": "NCT02924090_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02924090_exc_T32", "arg2_id": "NCT02924090_exc_T29", "normalized": [] } ]

[ { "id": "NCT02924090_inc_text", "type": "inclusion", "text": [ "Adults patients aged 18 to 85 years\nDiagnosed with Major Depressive Disorder, unipolar or bipolar depression\nUndergoing ECT for treatment of their symptoms\nCurrently residing in Manitoba\n" ], "offsets": [ [ 0, 187 ] ] } ]

[ { "id": "NCT02924090_inc_T1", "type": "Person", "text": [ "Adults" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "NCT02924090_inc_T2", "type": "Person", "text": [ "aged" ], "offsets": [ [ 16, 20 ] ], "normalized": [] }, { "id": "NCT02924090_inc_T3", "type": "Value", "text": [ "18 to 85 years" ], "offsets": [ [ 21, 35 ] ], "normalized": [] }, { "id": "NCT02924090_inc_T4", "type": "Condition", "text": [ "Major Depressive Disorder" ], "offsets": [ [ 51, 76 ] ], "normalized": [] }, { "id": "NCT02924090_inc_T5", "type": "Condition", "text": [ "nipolar", "epression" ], "offsets": [ [ 79, 86 ], [ 99, 108 ] ], "normalized": [] }, { "id": "NCT02924090_inc_T6", "type": "Condition", "text": [ "bipolar depression" ], "offsets": [ [ 90, 108 ] ], "normalized": [] }, { "id": "NCT02924090_inc_T7", "type": "Procedure", "text": [ "ECT" ], "offsets": [ [ 120, 123 ] ], "normalized": [] }, { "id": "NCT02924090_inc_T8", "type": "Temporal", "text": [ "Undergoing" ], "offsets": [ [ 109, 119 ] ], "normalized": [] }, { "id": "NCT02924090_inc_T9", "type": "Visit", "text": [ "Manitoba" ], "offsets": [ [ 178, 186 ] ], "normalized": [] }, { "id": "NCT02924090_inc_T10", "type": "Observation", "text": [ "Currently residing" ], "offsets": [ [ 156, 174 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02924090_inc_R1", "type": "Has_value", "arg1_id": "NCT02924090_inc_T2", "arg2_id": "NCT02924090_inc_T3", "normalized": [] }, { "id": "NCT02924090_inc_R2", "type": "Has_temporal", "arg1_id": "NCT02924090_inc_T7", "arg2_id": "NCT02924090_inc_T8", "normalized": [] }, { "id": "NCT02924090_inc_R3", "type": "AND", "arg1_id": "NCT02924090_inc_T10", "arg2_id": "NCT02924090_inc_T9", "normalized": [] } ]

[ { "id": "NCT02924870_exc_text", "type": "exclusion", "text": [ "osteoarticular, neuromuscular or cognitive limitation that prevents ambulation\nprevious diagnosis of active neoplastic disease\ninstitutionalized patients; alcohol consumption >60 g/day\npatient belonging to another health sector in the Community of Madrid or other community\nparticipation in another study within 6 months prior.\n" ], "offsets": [ [ 0, 328 ] ] } ]

[ { "id": "NCT02924870_exc_T1", "type": "Observation", "text": [ "osteoarticular", "limitation" ], "offsets": [ [ 0, 14 ], [ 43, 53 ] ], "normalized": [] }, { "id": "NCT02924870_exc_T2", "type": "Observation", "text": [ "neuromuscular", "limitation" ], "offsets": [ [ 16, 29 ], [ 43, 53 ] ], "normalized": [] }, { "id": "NCT02924870_exc_T3", "type": "Observation", "text": [ "cognitive limitation" ], "offsets": [ [ 33, 53 ] ], "normalized": [] }, { "id": "NCT02924870_exc_T4", "type": "Negation", "text": [ "prevents" ], "offsets": [ [ 59, 67 ] ], "normalized": [] }, { "id": "NCT02924870_exc_T5", "type": "Observation", "text": [ "ambulation" ], "offsets": [ [ 68, 78 ] ], "normalized": [] }, { "id": "NCT02924870_exc_T6", "type": "Condition", "text": [ "neoplastic disease" ], "offsets": [ [ 108, 126 ] ], "normalized": [] }, { "id": "NCT02924870_exc_T7", "type": "Person", "text": [ "institutionalized" ], "offsets": [ [ 127, 144 ] ], "normalized": [] }, { "id": "NCT02924870_exc_T8", "type": "Observation", "text": [ "alcohol consumption" ], "offsets": [ [ 155, 174 ] ], "normalized": [] }, { "id": "NCT02924870_exc_T9", "type": "Multiplier", "text": [ ">60 g/day" ], "offsets": [ [ 175, 184 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02924870_exc_R1", "type": "Has_negation", "arg1_id": "NCT02924870_exc_T5", "arg2_id": "NCT02924870_exc_T4", "normalized": [] }, { "id": "NCT02924870_exc_R2", "type": "Has_multiplier", "arg1_id": "NCT02924870_exc_T8", "arg2_id": "NCT02924870_exc_T9", "normalized": [] } ]

[ { "id": "NCT02924870_inc_text", "type": "inclusion", "text": [ "subjects older than 35 years\ndiagnosis of moderate to very severe COPD (FEV1 <80% predicted), according to the GesEPOC criteria, established at least 3 months\ncurrent or former smoker with an accumulated consumption >10 packs x year\nhospital admission for COPD exacerbation\n" ], "offsets": [ [ 0, 274 ] ] } ]

[ { "id": "NCT02924870_inc_T1", "type": "Person", "text": [ "years" ], "offsets": [ [ 23, 28 ] ], "normalized": [] }, { "id": "NCT02924870_inc_T2", "type": "Value", "text": [ "older than 35" ], "offsets": [ [ 9, 22 ] ], "normalized": [] }, { "id": "NCT02924870_inc_T3", "type": "Condition", "text": [ "COPD" ], "offsets": [ [ 66, 70 ] ], "normalized": [] }, { "id": "NCT02924870_inc_T4", "type": "Qualifier", "text": [ "moderate" ], "offsets": [ [ 42, 50 ] ], "normalized": [] }, { "id": "NCT02924870_inc_T5", "type": "Qualifier", "text": [ "very severe" ], "offsets": [ [ 54, 65 ] ], "normalized": [] }, { "id": "NCT02924870_inc_T6", "type": "Measurement", "text": [ "FEV1" ], "offsets": [ [ 72, 76 ] ], "normalized": [] }, { "id": "NCT02924870_inc_T7", "type": "Value", "text": [ "<80% predicted" ], "offsets": [ [ 77, 91 ] ], "normalized": [] }, { "id": "NCT02924870_inc_T8", "type": "Measurement", "text": [ "GesEPOC criteria," ], "offsets": [ [ 111, 128 ] ], "normalized": [] }, { "id": "NCT02924870_inc_T9", "type": "Temporal", "text": [ "at least 3 months" ], "offsets": [ [ 141, 158 ] ], "normalized": [] }, { "id": "NCT02924870_inc_T10", "type": "Scope", "text": [ "moderate to very severe" ], "offsets": [ [ 42, 65 ] ], "normalized": [] }, { "id": "NCT02924870_inc_T11", "type": "Person", "text": [ "smoker" ], "offsets": [ [ 177, 183 ] ], "normalized": [] }, { "id": "NCT02924870_inc_T12", "type": "Observation", "text": [ "consumption" ], "offsets": [ [ 204, 215 ] ], "normalized": [] }, { "id": "NCT02924870_inc_T13", "type": "Multiplier", "text": [ ">10 packs x year" ], "offsets": [ [ 216, 232 ] ], "normalized": [] }, { "id": "NCT02924870_inc_T14", "type": "Visit", "text": [ "admission" ], "offsets": [ [ 242, 251 ] ], "normalized": [] }, { "id": "NCT02924870_inc_T15", "type": "Condition", "text": [ "COPD exacerbation" ], "offsets": [ [ 256, 273 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT02924870_inc_R1", "type": "Has_value", "arg1_id": "NCT02924870_inc_T1", "arg2_id": "NCT02924870_inc_T2", "normalized": [] }, { "id": "NCT02924870_inc_R2", "type": "Has_value", "arg1_id": "NCT02924870_inc_T6", "arg2_id": "NCT02924870_inc_T7", "normalized": [] }, { "id": "NCT02924870_inc_R3", "type": "Has_temporal", "arg1_id": "NCT02924870_inc_T3", "arg2_id": "NCT02924870_inc_T9", "normalized": [] }, { "id": "NCT02924870_inc_R4", "type": "Has_scope", "arg1_id": "NCT02924870_inc_T3", "arg2_id": "NCT02924870_inc_T10", "normalized": [] }, { "id": "NCT02924870_inc_R5", "type": "AND", "arg1_id": "NCT02924870_inc_T8", "arg2_id": "NCT02924870_inc_T3", "normalized": [] }, { "id": "NCT02924870_inc_R6", "type": "AND", "arg1_id": "NCT02924870_inc_T3", "arg2_id": "NCT02924870_inc_T6", "normalized": [] }, { "id": "NCT02924870_inc_R7", "type": "Has_multiplier", "arg1_id": "NCT02924870_inc_T12", "arg2_id": "NCT02924870_inc_T13", "normalized": [] }, { "id": "NCT02924870_inc_R8", "type": "AND", "arg1_id": "NCT02924870_inc_T14", "arg2_id": "NCT02924870_inc_T15", "normalized": [] } ]

[ { "id": "NCT02926235_exc_text", "type": "exclusion", "text": [ "All patients who were wheelchair bound preoperatively\nAll patients who cannot participate in an outpatient physical therapy program for 3 days per week after surgery\n" ], "offsets": [ [ 0, 166 ] ] } ]

[ { "id": "NCT02926235_exc_T1", "type": "Qualifier", "text": [ "preoperatively" ], "offsets": [ [ 39, 53 ] ], "normalized": [] }, { "id": "NCT02926235_exc_T2", "type": "Observation", "text": [ "wheelchair bound" ], "offsets": [ [ 22, 38 ] ], "normalized": [] }, { "id": "NCT02926235_exc_T3", "type": "Negation", "text": [ "cannot" ], "offsets": [ [ 71, 77 ] ], "normalized": [] }, { "id": "NCT02926235_exc_T4", "type": "Procedure", "text": [ "physical therapy" ], "offsets": [ [ 107, 123 ] ], "normalized": [] }, { "id": "NCT02926235_exc_T5", "type": "Visit", "text": [ "outpatient" ], "offsets": [ [ 96, 106 ] ], "normalized": [] }, { "id": "NCT02926235_exc_T6", "type": "Temporal", "text": [ "for 3 days per week after surgery" ], "offsets": [ [ 132, 165 ] ], "normalized": [] }, { "id": "NCT02926235_exc_T7", "type": "Reference_point", "text": [ "surgery" ], "offsets": [ [ 158, 165 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02926235_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02926235_exc_T2", "arg2_id": "NCT02926235_exc_T1", "normalized": [] }, { "id": "NCT02926235_exc_R2", "type": "Has_index", "arg1_id": "NCT02926235_exc_T6", "arg2_id": "NCT02926235_exc_T7", "normalized": [] }, { "id": "NCT02926235_exc_R3", "type": "AND", "arg1_id": "NCT02926235_exc_T4", "arg2_id": "NCT02926235_exc_T5", "normalized": [] }, { "id": "NCT02926235_exc_R4", "type": "Has_negation", "arg1_id": "NCT02926235_exc_T4", "arg2_id": "NCT02926235_exc_T3", "normalized": [] }, { "id": "NCT02926235_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02926235_exc_T4", "arg2_id": "NCT02926235_exc_T6", "normalized": [] } ]

[ { "id": "NCT02926235_inc_text", "type": "inclusion", "text": [ "All patients will be undergoing a primary unilateral total knee arthroplasty for a diagnosis of osteoarthritis\n" ], "offsets": [ [ 0, 111 ] ] } ]

[ { "id": "NCT02926235_inc_T1", "type": "Condition", "text": [ "osteoarthritis" ], "offsets": [ [ 96, 110 ] ], "normalized": [] }, { "id": "NCT02926235_inc_T2", "type": "Procedure", "text": [ "unilateral total knee arthroplasty" ], "offsets": [ [ 42, 76 ] ], "normalized": [] }, { "id": "NCT02926235_inc_T3", "type": "Qualifier", "text": [ "primary" ], "offsets": [ [ 34, 41 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02926235_inc_R1", "type": "AND", "arg1_id": "NCT02926235_inc_T2", "arg2_id": "NCT02926235_inc_T1", "normalized": [] }, { "id": "NCT02926235_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02926235_inc_T2", "arg2_id": "NCT02926235_inc_T3", "normalized": [] } ]

[ { "id": "NCT02926989_exc_text", "type": "exclusion", "text": [ "An initial plasma sodium concentration of lower than 130 mmol/L\nAn initial plasma sodium concentration of higher than 150 mmol/L\nAn initial plasma potassium concentration of lower than 3.0 mmol/L\nNeed for 10% glucose solution\nDiabetes\nDiabetes insipidus\nDiabetic ketoacidosis\nRenal disease that needs dialysis\nProtocol-determined chemotherapy hydration\nSevere liver disease\nInborn errors of metabolism that need protocol-determined fluid therapy\n" ], "offsets": [ [ 0, 446 ] ] } ]

[ { "id": "NCT02926989_exc_T1", "type": "Multiplier", "text": [ "initial" ], "offsets": [ [ 3, 10 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T2", "type": "Multiplier", "text": [ "initial" ], "offsets": [ [ 67, 74 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T3", "type": "Multiplier", "text": [ "initial" ], "offsets": [ [ 132, 139 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T4", "type": "Measurement", "text": [ "plasma sodium concentration" ], "offsets": [ [ 11, 38 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T5", "type": "Measurement", "text": [ "plasma sodium concentration" ], "offsets": [ [ 75, 102 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T6", "type": "Measurement", "text": [ "plasma potassium concentration" ], "offsets": [ [ 140, 170 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T7", "type": "Value", "text": [ "lower than 130 mmol/L" ], "offsets": [ [ 42, 63 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T8", "type": "Value", "text": [ "higher than 150 mmol/L" ], "offsets": [ [ 106, 128 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T9", "type": "Value", "text": [ "lower than 3.0 mmol/L" ], "offsets": [ [ 174, 195 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T10", "type": "Mood", "text": [ "Need for" ], "offsets": [ [ 196, 204 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T11", "type": "Drug", "text": [ "10% glucose solution" ], "offsets": [ [ 205, 225 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T12", "type": "Condition", "text": [ "Diabetes" ], "offsets": [ [ 226, 234 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T13", "type": "Condition", "text": [ "Diabetes insipidus" ], "offsets": [ [ 235, 253 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T14", "type": "Condition", "text": [ "Diabetic ketoacidosis" ], "offsets": [ [ 254, 275 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T15", "type": "Condition", "text": [ "Renal disease" ], "offsets": [ [ 276, 289 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T16", "type": "Mood", "text": [ "needs" ], "offsets": [ [ 295, 300 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T17", "type": "Procedure", "text": [ "dialysis" ], "offsets": [ [ 301, 309 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T18", "type": "Qualifier", "text": [ "Protocol-determined" ], "offsets": [ [ 310, 329 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T19", "type": "Procedure", "text": [ "chemotherapy hydration" ], "offsets": [ [ 330, 352 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T20", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 353, 359 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T21", "type": "Condition", "text": [ "liver disease" ], "offsets": [ [ 360, 373 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T22", "type": "Condition", "text": [ "Inborn errors of metabolism" ], "offsets": [ [ 374, 401 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T23", "type": "Mood", "text": [ "need" ], "offsets": [ [ 407, 411 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T24", "type": "Qualifier", "text": [ "protocol-determined" ], "offsets": [ [ 412, 431 ] ], "normalized": [] }, { "id": "NCT02926989_exc_T25", "type": "Procedure", "text": [ "fluid therapy" ], "offsets": [ [ 432, 445 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02926989_exc_R1", "type": "Has_value", "arg1_id": "NCT02926989_exc_T4", "arg2_id": "NCT02926989_exc_T7", "normalized": [] }, { "id": "NCT02926989_exc_R2", "type": "Has_value", "arg1_id": "NCT02926989_exc_T5", "arg2_id": "NCT02926989_exc_T8", "normalized": [] }, { "id": "NCT02926989_exc_R3", "type": "Has_value", "arg1_id": "NCT02926989_exc_T6", "arg2_id": "NCT02926989_exc_T9", "normalized": [] }, { "id": "NCT02926989_exc_R4", "type": "Has_multiplier", "arg1_id": "NCT02926989_exc_T4", "arg2_id": "NCT02926989_exc_T1", "normalized": [] }, { "id": "NCT02926989_exc_R5", "type": "Has_multiplier", "arg1_id": "NCT02926989_exc_T5", "arg2_id": "NCT02926989_exc_T2", "normalized": [] }, { "id": "NCT02926989_exc_R6", "type": "Has_multiplier", "arg1_id": "NCT02926989_exc_T6", "arg2_id": "NCT02926989_exc_T3", "normalized": [] }, { "id": "NCT02926989_exc_R7", "type": "Has_mood", "arg1_id": "NCT02926989_exc_T11", "arg2_id": "NCT02926989_exc_T10", "normalized": [] }, { "id": "NCT02926989_exc_R8", "type": "Has_mood", "arg1_id": "NCT02926989_exc_T17", "arg2_id": "NCT02926989_exc_T16", "normalized": [] }, { "id": "NCT02926989_exc_R9", "type": "AND", "arg1_id": "NCT02926989_exc_T15", "arg2_id": "NCT02926989_exc_T17", "normalized": [] }, { "id": "NCT02926989_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT02926989_exc_T19", "arg2_id": "NCT02926989_exc_T18", "normalized": [] }, { "id": "NCT02926989_exc_R11", "type": "Has_qualifier", "arg1_id": "NCT02926989_exc_T21", "arg2_id": "NCT02926989_exc_T20", "normalized": [] }, { "id": "NCT02926989_exc_R12", "type": "Has_qualifier", "arg1_id": "NCT02926989_exc_T25", "arg2_id": "NCT02926989_exc_T24", "normalized": [] }, { "id": "NCT02926989_exc_R13", "type": "Has_mood", "arg1_id": "NCT02926989_exc_T25", "arg2_id": "NCT02926989_exc_T23", "normalized": [] }, { "id": "NCT02926989_exc_R14", "type": "AND", "arg1_id": "NCT02926989_exc_T22", "arg2_id": "NCT02926989_exc_T25", "normalized": [] } ]

[ { "id": "NCT02926989_inc_text", "type": "inclusion", "text": [ "Acutely ill hospitalised children\nNeed for intravenous fluid therapy\n" ], "offsets": [ [ 0, 69 ] ] } ]

[ { "id": "NCT02926989_inc_T1", "type": "Condition", "text": [ "Acutely ill" ], "offsets": [ [ 0, 11 ] ], "normalized": [] }, { "id": "NCT02926989_inc_T2", "type": "Observation", "text": [ "hospitalised" ], "offsets": [ [ 12, 24 ] ], "normalized": [] }, { "id": "NCT02926989_inc_T3", "type": "Person", "text": [ "children" ], "offsets": [ [ 25, 33 ] ], "normalized": [] }, { "id": "NCT02926989_inc_T4", "type": "Mood", "text": [ "Need for" ], "offsets": [ [ 34, 42 ] ], "normalized": [] }, { "id": "NCT02926989_inc_T5", "type": "Procedure", "text": [ "intravenous fluid therapy" ], "offsets": [ [ 43, 68 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02926989_inc_R1", "type": "Has_mood", "arg1_id": "NCT02926989_inc_T5", "arg2_id": "NCT02926989_inc_T4", "normalized": [] } ]

[ { "id": "NCT02933671_exc_text", "type": "exclusion", "text": [ "ASA 4 or 5\nrevision hip arthroplasty\ndiagnosis of chronic pain\ndaily chronic opioid use (over 3 months of continuous opioid use)\ninability to communicate pain scores or need for analgesia\nacute hip fracture\nInfection at the site of block placement\nAge under 18 years old or greater than 75 years old\nPregnant women\nIntolerance/allergy to local anesthetics\nWeight <50 kg\nSuspected, or known addiction to or abuse of illicit drug(s), prescription medicine(s), or alcohol within the past 2 years.\nUncontrolled anxiety, schizophrenia, or other psychiatric disorder that, in the opinion of the investigator, may interfere with study assessments or compliance\nCurrent or historical evidence of any clinically significant disease or condition that, in the opinion of the investigator, may increase the risk of surgery or complicate the subject's postoperative course.\n" ], "offsets": [ [ 0, 861 ] ] } ]

[ { "id": "NCT02933671_exc_T1", "type": "Measurement", "text": [ "ASA" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T2", "type": "Value", "text": [ "4 or 5" ], "offsets": [ [ 4, 10 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T3", "type": "Procedure", "text": [ "revision hip arthroplasty" ], "offsets": [ [ 11, 36 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T4", "type": "Condition", "text": [ "chronic pain" ], "offsets": [ [ 50, 62 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T5", "type": "Drug", "text": [ "opioid" ], "offsets": [ [ 77, 83 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T6", "type": "Qualifier", "text": [ "chronic" ], "offsets": [ [ 69, 76 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T7", "type": "Temporal", "text": [ "over 3 months" ], "offsets": [ [ 89, 102 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T9", "type": "Condition", "text": [ "hip fracture" ], "offsets": [ [ 194, 206 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T10", "type": "Qualifier", "text": [ "acute" ], "offsets": [ [ 188, 193 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T11", "type": "Condition", "text": [ "Infection" ], "offsets": [ [ 207, 216 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T12", "type": "Qualifier", "text": [ "site of block placement" ], "offsets": [ [ 224, 247 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T13", "type": "Person", "text": [ "Age" ], "offsets": [ [ 248, 251 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T14", "type": "Value", "text": [ "under 18 years old or greater than 75 years old" ], "offsets": [ [ 252, 299 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T16", "type": "Condition", "text": [ "Intolerance" ], "offsets": [ [ 315, 326 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T17", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 327, 334 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T18", "type": "Drug", "text": [ "local anesthetics" ], "offsets": [ [ 338, 355 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T19", "type": "Scope", "text": [ "Intolerance/allergy" ], "offsets": [ [ 315, 334 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T20", "type": "Person", "text": [ "Weight" ], "offsets": [ [ 356, 362 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T21", "type": "Value", "text": [ "<50 kg" ], "offsets": [ [ 363, 369 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T22", "type": "Condition", "text": [ "abuse" ], "offsets": [ [ 406, 411 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T23", "type": "Condition", "text": [ "addiction" ], "offsets": [ [ 390, 399 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T24", "type": "Qualifier", "text": [ "prescription medicine" ], "offsets": [ [ 432, 453 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T25", "type": "Qualifier", "text": [ "alcohol" ], "offsets": [ [ 461, 468 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T26", "type": "Qualifier", "text": [ "illicit drug" ], "offsets": [ [ 415, 427 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T27", "type": "Scope", "text": [ "illicit drug(s), prescription medicine(s), or alcohol" ], "offsets": [ [ 415, 468 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T28", "type": "Scope", "text": [ "addiction to or abuse" ], "offsets": [ [ 390, 411 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T29", "type": "Temporal", "text": [ "past 2 years" ], "offsets": [ [ 480, 492 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T30", "type": "Condition", "text": [ "anxiety" ], "offsets": [ [ 507, 514 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T31", "type": "Condition", "text": [ "schizophrenia" ], "offsets": [ [ 516, 529 ] ], "normalized": [] }, { "id": "NCT02933671_exc_T32", "type": "Condition", "text": [ "psychiatric disorder" ], "offsets": [ [ 540, 560 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02933671_exc_R1", "type": "Has_value", "arg1_id": "NCT02933671_exc_T1", "arg2_id": "NCT02933671_exc_T2", "normalized": [] }, { "id": "NCT02933671_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02933671_exc_T5", "arg2_id": "NCT02933671_exc_T6", "normalized": [] }, { "id": "NCT02933671_exc_R3", "type": "Has_temporal", "arg1_id": "NCT02933671_exc_T5", "arg2_id": "NCT02933671_exc_T7", "normalized": [] }, { "id": "NCT02933671_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT02933671_exc_T9", "arg2_id": "NCT02933671_exc_T10", "normalized": [] }, { "id": "NCT02933671_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02933671_exc_T11", "arg2_id": "NCT02933671_exc_T12", "normalized": [] }, { "id": "NCT02933671_exc_R6", "type": "Has_value", "arg1_id": "NCT02933671_exc_T13", "arg2_id": "NCT02933671_exc_T14", "normalized": [] }, { "id": "NCT02933671_exc_R7", "type": "AND", "arg1_id": "NCT02933671_exc_T19", "arg2_id": "NCT02933671_exc_T18", "normalized": [] }, { "id": "NCT02933671_exc_R8", "type": "Has_value", "arg1_id": "NCT02933671_exc_T20", "arg2_id": "NCT02933671_exc_T21", "normalized": [] }, { "id": "NCT02933671_exc_R9", "type": "Has_temporal", "arg1_id": "NCT02933671_exc_T28", "arg2_id": "NCT02933671_exc_T29", "normalized": [] }, { "id": "NCT02933671_exc_R10", "type": "Has_scope", "arg1_id": "NCT02933671_exc_T28", "arg2_id": "NCT02933671_exc_T27", "normalized": [] } ]

[ { "id": "NCT02933671_inc_text", "type": "inclusion", "text": [ "English speaking\nbetween 18 and 75 years old\nAmerican Society of Anesthesiologists (ASA) 1-3 patients undergoing primary total hip arthroplasty\n" ], "offsets": [ [ 0, 144 ] ] } ]

[ { "id": "NCT02933671_inc_T2", "type": "Person", "text": [ "old" ], "offsets": [ [ 41, 44 ] ], "normalized": [] }, { "id": "NCT02933671_inc_T3", "type": "Value", "text": [ "between 18 and 75 years" ], "offsets": [ [ 17, 40 ] ], "normalized": [] }, { "id": "NCT02933671_inc_T4", "type": "Measurement", "text": [ "American Society of Anesthesiologists" ], "offsets": [ [ 45, 82 ] ], "normalized": [] }, { "id": "NCT02933671_inc_T5", "type": "Measurement", "text": [ "ASA" ], "offsets": [ [ 84, 87 ] ], "normalized": [] }, { "id": "NCT02933671_inc_T6", "type": "Value", "text": [ "1-3" ], "offsets": [ [ 89, 92 ] ], "normalized": [] }, { "id": "NCT02933671_inc_T7", "type": "Procedure", "text": [ "primary total hip arthroplasty" ], "offsets": [ [ 113, 143 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02933671_inc_R1", "type": "Has_value", "arg1_id": "NCT02933671_inc_T2", "arg2_id": "NCT02933671_inc_T3", "normalized": [] }, { "id": "NCT02933671_inc_R2", "type": "Subsumes", "arg1_id": "NCT02933671_inc_T4", "arg2_id": "NCT02933671_inc_T5", "normalized": [] }, { "id": "NCT02933671_inc_R3", "type": "Has_value", "arg1_id": "NCT02933671_inc_T4", "arg2_id": "NCT02933671_inc_T6", "normalized": [] } ]

[ { "id": "NCT02934269_exc_text", "type": "exclusion", "text": [ "Exposure/treatment to an investigational (new chemical entity) or marketed drug or biologic within 30 days preceding the first dose administration, or five half-lives of that investigational drug or biologic, if known (whichever is longer). \nDonation blood or serum within 8 weeks before the first dose administration to a blood bank or blood donation center. \nHistory of alcohol or drug abuse (as defined by the current version of the DSM) within 2 years before the first dose administration, or positive alcohol or drug screen. \nVaccination within 30 days prior to the first dose administration or has plans to receive a vaccination during the course of the study (including the follow phone call on Day 105). \n \n" ], "offsets": [ [ 0, 724 ] ] } ]

[ { "id": "NCT02934269_exc_T3", "type": "Procedure", "text": [ "Donation blood" ], "offsets": [ [ 242, 256 ] ], "normalized": [] }, { "id": "NCT02934269_exc_T5", "type": "Procedure", "text": [ "Donation", "serum" ], "offsets": [ [ 242, 250 ], [ 260, 265 ] ], "normalized": [] }, { "id": "NCT02934269_exc_T7", "type": "Temporal", "text": [ "within 8 weeks before" ], "offsets": [ [ 266, 287 ] ], "normalized": [] }, { "id": "NCT02934269_exc_T8", "type": "Reference_point", "text": [ "first dose administration" ], "offsets": [ [ 292, 317 ] ], "normalized": [] }, { "id": "NCT02934269_exc_T9", "type": "Condition", "text": [ "alcohol", "abuse" ], "offsets": [ [ 372, 379 ], [ 388, 393 ] ], "normalized": [] }, { "id": "NCT02934269_exc_T10", "type": "Condition", "text": [ "drug abuse" ], "offsets": [ [ 383, 393 ] ], "normalized": [] }, { "id": "NCT02934269_exc_T11", "type": "Observation", "text": [ "History" ], "offsets": [ [ 361, 368 ] ], "normalized": [] }, { "id": "NCT02934269_exc_T12", "type": "Procedure", "text": [ "current version of the DSM" ], "offsets": [ [ 413, 439 ] ], "normalized": [] }, { "id": "NCT02934269_exc_T13", "type": "Temporal", "text": [ "within 2 years before" ], "offsets": [ [ 441, 462 ] ], "normalized": [] }, { "id": "NCT02934269_exc_T14", "type": "Reference_point", "text": [ "the first dose administration" ], "offsets": [ [ 463, 492 ] ], "normalized": [] }, { "id": "NCT02934269_exc_T15", "type": "Measurement", "text": [ "alcohol", "screen" ], "offsets": [ [ 506, 513 ], [ 522, 528 ] ], "normalized": [] }, { "id": "NCT02934269_exc_T16", "type": "Measurement", "text": [ "drug screen" ], "offsets": [ [ 517, 528 ] ], "normalized": [] }, { "id": "NCT02934269_exc_T17", "type": "Value", "text": [ "positive" ], "offsets": [ [ 497, 505 ] ], "normalized": [] }, { "id": "NCT02934269_exc_T18", "type": "Scope", "text": [ "alcohol or drug abuse" ], "offsets": [ [ 372, 393 ] ], "normalized": [] }, { "id": "NCT02934269_exc_T19", "type": "Procedure", "text": [ "Vaccination" ], "offsets": [ [ 531, 542 ] ], "normalized": [] }, { "id": "NCT02934269_exc_T20", "type": "Temporal", "text": [ "within 30 days prior" ], "offsets": [ [ 543, 563 ] ], "normalized": [] }, { "id": "NCT02934269_exc_T21", "type": "Reference_point", "text": [ "the first dose administration" ], "offsets": [ [ 567, 596 ] ], "normalized": [] }, { "id": "NCT02934269_exc_T22", "type": "Observation", "text": [ "plans" ], "offsets": [ [ 604, 609 ] ], "normalized": [] }, { "id": "NCT02934269_exc_T24", "type": "Procedure", "text": [ "vaccination" ], "offsets": [ [ 623, 634 ] ], "normalized": [] }, { "id": "NCT02934269_exc_T25", "type": "Temporal", "text": [ "during the course" ], "offsets": [ [ 635, 652 ] ], "normalized": [] }, { "id": "NCT02934269_exc_T26", "type": "Reference_point", "text": [ "study" ], "offsets": [ [ 660, 665 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02934269_exc_R1", "type": "Has_index", "arg1_id": "NCT02934269_exc_T7", "arg2_id": "NCT02934269_exc_T8", "normalized": [] }, { "id": "NCT02934269_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02934269_exc_T5", "arg2_id": "NCT02934269_exc_T7", "normalized": [] }, { "id": "NCT02934269_exc_R3", "type": "Has_temporal", "arg1_id": "NCT02934269_exc_T3", "arg2_id": "NCT02934269_exc_T7", "normalized": [] }, { "id": "NCT02934269_exc_R6", "type": "AND", "arg1_id": "NCT02934269_exc_T10", "arg2_id": "NCT02934269_exc_T12", "normalized": [] }, { "id": "NCT02934269_exc_R7", "type": "AND", "arg1_id": "NCT02934269_exc_T9", "arg2_id": "NCT02934269_exc_T12", "normalized": [] }, { "id": "NCT02934269_exc_R8", "type": "Has_index", "arg1_id": "NCT02934269_exc_T13", "arg2_id": "NCT02934269_exc_T14", "normalized": [] }, { "id": "NCT02934269_exc_R9", "type": "Has_value", "arg1_id": "NCT02934269_exc_T15", "arg2_id": "NCT02934269_exc_T17", "normalized": [] }, { "id": "NCT02934269_exc_R10", "type": "Has_value", "arg1_id": "NCT02934269_exc_T16", "arg2_id": "NCT02934269_exc_T17", "normalized": [] }, { "id": "NCT02934269_exc_R4", "type": "Has_temporal", "arg1_id": "NCT02934269_exc_T18", "arg2_id": "NCT02934269_exc_T11", "normalized": [] }, { "id": "NCT02934269_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02934269_exc_T18", "arg2_id": "NCT02934269_exc_T13", "normalized": [] }, { "id": "NCT02934269_exc_R11", "type": "Has_index", "arg1_id": "NCT02934269_exc_T25", "arg2_id": "NCT02934269_exc_T26", "normalized": [] }, { "id": "NCT02934269_exc_R12", "type": "Has_index", "arg1_id": "NCT02934269_exc_T20", "arg2_id": "NCT02934269_exc_T21", "normalized": [] }, { "id": "NCT02934269_exc_R13", "type": "Has_temporal", "arg1_id": "NCT02934269_exc_T19", "arg2_id": "NCT02934269_exc_T20", "normalized": [] }, { "id": "NCT02934269_exc_R14", "type": "Has_mood", "arg1_id": "NCT02934269_exc_T24", "arg2_id": "NCT02934269_exc_T22", "normalized": [] }, { "id": "NCT02934269_exc_R15", "type": "Has_temporal", "arg1_id": "NCT02934269_exc_T24", "arg2_id": "NCT02934269_exc_T25", "normalized": [] } ]

[ { "id": "NCT02934269_inc_text", "type": "inclusion", "text": [ "Healthy male and/or female subjects between the ages of 18 and 55 years, and a body mass index (BMI) of ≥ 18 and ≤ 33 kg/m2 with body weight ≥ 50 and ≤ 90 kg at screening. \nFemales must have been surgically sterilized (hysterectomy, bilateral oophorectomy, or bilateral salpingo-oophorectomy; proper documentation required) at least 6 months before screening, or be postmenopausal (defined as 24 consecutive months without menses before screening, with a follicle-stimulating hormone [FSH] level of > 40 IU/L at screening). \n" ], "offsets": [ [ 0, 525 ] ] } ]

[ { "id": "NCT02934269_inc_T1", "type": "Person", "text": [ "male" ], "offsets": [ [ 8, 12 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T2", "type": "Condition", "text": [ "Healthy" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T3", "type": "Person", "text": [ "female" ], "offsets": [ [ 20, 26 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T4", "type": "Person", "text": [ "ages" ], "offsets": [ [ 48, 52 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T5", "type": "Value", "text": [ "between", "18 and 55 years" ], "offsets": [ [ 36, 43 ], [ 56, 71 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T6", "type": "Measurement", "text": [ "body mass index (BMI)" ], "offsets": [ [ 79, 100 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T7", "type": "Value", "text": [ "≥ 18 and ≤ 33 kg/m2" ], "offsets": [ [ 104, 123 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T8", "type": "Measurement", "text": [ "body weight" ], "offsets": [ [ 129, 140 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T9", "type": "Value", "text": [ "≥ 50 and ≤ 90 kg" ], "offsets": [ [ 141, 157 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T10", "type": "Temporal", "text": [ "at screening" ], "offsets": [ [ 158, 170 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T11", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 161, 170 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T12", "type": "Scope", "text": [ "body mass index (BMI) of ≥ 18 and ≤ 33 kg/m2 with body weight ≥ 50 and ≤ 90 kg" ], "offsets": [ [ 79, 157 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T13", "type": "Person", "text": [ "Females" ], "offsets": [ [ 173, 180 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T14", "type": "Condition", "text": [ "surgically sterilized" ], "offsets": [ [ 196, 217 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T15", "type": "Procedure", "text": [ "hysterectomy" ], "offsets": [ [ 219, 231 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T16", "type": "Procedure", "text": [ "bilateral oophorectomy" ], "offsets": [ [ 233, 255 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T17", "type": "Procedure", "text": [ "bilateral salpingo-oophorectomy" ], "offsets": [ [ 260, 291 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T18", "type": "Temporal", "text": [ "at least 6 months before" ], "offsets": [ [ 324, 348 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T19", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 349, 358 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T20", "type": "Scope", "text": [ "hysterectomy, bilateral oophorectomy, or bilateral salpingo-oophorectomy" ], "offsets": [ [ 219, 291 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T21", "type": "Condition", "text": [ "postmenopausal" ], "offsets": [ [ 366, 380 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T22", "type": "Temporal", "text": [ "24 consecutive months" ], "offsets": [ [ 393, 414 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T23", "type": "Condition", "text": [ "menses" ], "offsets": [ [ 423, 429 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T24", "type": "Negation", "text": [ "without" ], "offsets": [ [ 415, 422 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T25", "type": "Temporal", "text": [ "before screening" ], "offsets": [ [ 430, 446 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T26", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 437, 446 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T27", "type": "Measurement", "text": [ "follicle-stimulating hormone [FSH]" ], "offsets": [ [ 455, 489 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T28", "type": "Value", "text": [ "> 40 IU/L" ], "offsets": [ [ 499, 508 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T29", "type": "Temporal", "text": [ "at screening" ], "offsets": [ [ 509, 521 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T30", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 512, 521 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T31", "type": "Scope", "text": [ "24 consecutive months without menses before screening, with a follicle-stimulating hormone [FSH] level of > 40 IU/L at screening" ], "offsets": [ [ 393, 521 ] ], "normalized": [] }, { "id": "NCT02934269_inc_T32", "type": "Scope", "text": [ "surgically sterilized (hysterectomy, bilateral oophorectomy, or bilateral salpingo-oophorectomy; proper documentation required) at least 6 months before screening, or be postmenopausal (defined as 24 consecutive months without menses before screening, with a follicle-stimulating hormone [FSH] level of > 40 IU/L at screening)" ], "offsets": [ [ 196, 522 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT02934269_inc_R1", "type": "Has_value", "arg1_id": "NCT02934269_inc_T4", "arg2_id": "NCT02934269_inc_T5", "normalized": [] }, { "id": "NCT02934269_inc_R2", "type": "Has_value", "arg1_id": "NCT02934269_inc_T6", "arg2_id": "NCT02934269_inc_T7", "normalized": [] }, { "id": "NCT02934269_inc_R3", "type": "Has_value", "arg1_id": "NCT02934269_inc_T8", "arg2_id": "NCT02934269_inc_T9", "normalized": [] }, { "id": "NCT02934269_inc_R4", "type": "Has_index", "arg1_id": "NCT02934269_inc_T10", "arg2_id": "NCT02934269_inc_T11", "normalized": [] }, { "id": "NCT02934269_inc_R5", "type": "Has_temporal", "arg1_id": "NCT02934269_inc_T12", "arg2_id": "NCT02934269_inc_T10", "normalized": [] }, { "id": "NCT02934269_inc_R6", "type": "Has_index", "arg1_id": "NCT02934269_inc_T18", "arg2_id": "NCT02934269_inc_T19", "normalized": [] }, { "id": "NCT02934269_inc_R7", "type": "Subsumes", "arg1_id": "NCT02934269_inc_T14", "arg2_id": "NCT02934269_inc_T20", "normalized": [] }, { "id": "NCT02934269_inc_R8", "type": "Has_temporal", "arg1_id": "NCT02934269_inc_T14", "arg2_id": "NCT02934269_inc_T18", "normalized": [] }, { "id": "NCT02934269_inc_R9", "type": "Has_negation", "arg1_id": "NCT02934269_inc_T23", "arg2_id": "NCT02934269_inc_T24", "normalized": [] }, { "id": "NCT02934269_inc_R10", "type": "Has_temporal", "arg1_id": "NCT02934269_inc_T23", "arg2_id": "NCT02934269_inc_T22", "normalized": [] }, { "id": "NCT02934269_inc_R11", "type": "Has_index", "arg1_id": "NCT02934269_inc_T25", "arg2_id": "NCT02934269_inc_T26", "normalized": [] }, { "id": "NCT02934269_inc_R12", "type": "Has_index", "arg1_id": "NCT02934269_inc_T29", "arg2_id": "NCT02934269_inc_T30", "normalized": [] }, { "id": "NCT02934269_inc_R13", "type": "Has_temporal", "arg1_id": "NCT02934269_inc_T27", "arg2_id": "NCT02934269_inc_T29", "normalized": [] }, { "id": "NCT02934269_inc_R14", "type": "Has_value", "arg1_id": "NCT02934269_inc_T27", "arg2_id": "NCT02934269_inc_T28", "normalized": [] }, { "id": "NCT02934269_inc_R15", "type": "Has_temporal", "arg1_id": "NCT02934269_inc_T23", "arg2_id": "NCT02934269_inc_T25", "normalized": [] }, { "id": "NCT02934269_inc_R16", "type": "Subsumes", "arg1_id": "NCT02934269_inc_T21", "arg2_id": "NCT02934269_inc_T31", "normalized": [] }, { "id": "NCT02934269_inc_R17", "type": "Has_scope", "arg1_id": "NCT02934269_inc_T13", "arg2_id": "NCT02934269_inc_T32", "normalized": [] } ]

[ { "id": "NCT02935855_exc_text", "type": "exclusion", "text": [ "patients with cancer\npatients with chronic inflammation diseases\n" ], "offsets": [ [ 0, 65 ] ] } ]

[ { "id": "NCT02935855_exc_T1", "type": "Condition", "text": [ "cancer" ], "offsets": [ [ 14, 20 ] ], "normalized": [] }, { "id": "NCT02935855_exc_T2", "type": "Condition", "text": [ "chronic inflammation diseases" ], "offsets": [ [ 35, 64 ] ], "normalized": [] } ]

[]

[]

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[ { "id": "NCT02935855_inc_text", "type": "inclusion", "text": [ "non-valvular atrial fibrillation\nnondiabetic patients\ntype 1 and 2 diabetic patients\n" ], "offsets": [ [ 0, 85 ] ] } ]

[ { "id": "NCT02935855_inc_T1", "type": "Condition", "text": [ "atrial fibrillation" ], "offsets": [ [ 13, 32 ] ], "normalized": [] }, { "id": "NCT02935855_inc_T2", "type": "Qualifier", "text": [ "non-valvular" ], "offsets": [ [ 0, 12 ] ], "normalized": [] }, { "id": "NCT02935855_inc_T3", "type": "Condition", "text": [ "diabetic" ], "offsets": [ [ 36, 44 ] ], "normalized": [] }, { "id": "NCT02935855_inc_T4", "type": "Negation", "text": [ "non" ], "offsets": [ [ 33, 36 ] ], "normalized": [] }, { "id": "NCT02935855_inc_T5", "type": "Condition", "text": [ "diabetic" ], "offsets": [ [ 67, 75 ] ], "normalized": [] }, { "id": "NCT02935855_inc_T6", "type": "Qualifier", "text": [ "type 1" ], "offsets": [ [ 54, 60 ] ], "normalized": [] }, { "id": "NCT02935855_inc_T7", "type": "Qualifier", "text": [ "pe 1", "d" ], "offsets": [ [ 56, 60 ], [ 67, 68 ] ], "normalized": [] }, { "id": "NCT02935855_inc_T8", "type": "Scope", "text": [ "type 1 and 2" ], "offsets": [ [ 54, 66 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT02935855_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT02935855_inc_T1", "arg2_id": "NCT02935855_inc_T2", "normalized": [] }, { "id": "NCT02935855_inc_R2", "type": "Has_negation", "arg1_id": "NCT02935855_inc_T3", "arg2_id": "NCT02935855_inc_T4", "normalized": [] }, { "id": "NCT02935855_inc_R3", "type": "Has_scope", "arg1_id": "NCT02935855_inc_T5", "arg2_id": "NCT02935855_inc_T8", "normalized": [] } ]

[ { "id": "NCT02937779_exc_text", "type": "exclusion", "text": [ "Women refusing HBs Ag test\nHIV co-infection\nHCV co-infection\nHBV treatment ongoing at the day of inclusion\nCreatinine clearance < 30 mL/min\nSevere gravidic disease present at inclusion involving life threatening to the mother and/or the child\nEvidence of pre-existing fetal anomalies incompatible with the child's life\nImminent child's birth defined as cervix dilatation up to 7 centimeters\nIntention to deliver in a maternity not linked to the study\nAny concomitant medical condition that, according to the clinical site investigator would contraindicate participation in the study.\nConcurrent participation in any other clinical trial without written agreement of the two study teams\n" ], "offsets": [ [ 0, 686 ] ] } ]

[ { "id": "NCT02937779_exc_T1", "type": "Measurement", "text": [ "HBs Ag test" ], "offsets": [ [ 15, 26 ] ], "normalized": [] }, { "id": "NCT02937779_exc_T2", "type": "Negation", "text": [ "refusing" ], "offsets": [ [ 6, 14 ] ], "normalized": [] }, { "id": "NCT02937779_exc_T3", "type": "Condition", "text": [ "co-infection" ], "offsets": [ [ 31, 43 ] ], "normalized": [] }, { "id": "NCT02937779_exc_T4", "type": "Condition", "text": [ "co-infection" ], "offsets": [ [ 48, 60 ] ], "normalized": [] }, { "id": "NCT02937779_exc_T5", "type": "Qualifier", "text": [ "HIV" ], "offsets": [ [ 27, 30 ] ], "normalized": [] }, { "id": "NCT02937779_exc_T6", "type": "Qualifier", "text": [ "HCV" ], "offsets": [ [ 44, 47 ] ], "normalized": [] }, { "id": "NCT02937779_exc_T7", "type": "Procedure", "text": [ "HBV treatment" ], "offsets": [ [ 61, 74 ] ], "normalized": [] }, { "id": "NCT02937779_exc_T8", "type": "Measurement", "text": [ "Creatinine clearance" ], "offsets": [ [ 107, 127 ] ], "normalized": [] }, { "id": "NCT02937779_exc_T9", "type": "Value", "text": [ "< 30 mL/min" ], "offsets": [ [ 128, 139 ] ], "normalized": [] }, { "id": "NCT02937779_exc_T10", "type": "Condition", "text": [ "gravidic disease" ], "offsets": [ [ 147, 163 ] ], "normalized": [] }, { "id": "NCT02937779_exc_T11", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 140, 146 ] ], "normalized": [] }, { "id": "NCT02937779_exc_T12", "type": "Qualifier", "text": [ "life threatening" ], "offsets": [ [ 195, 211 ] ], "normalized": [] }, { "id": "NCT02937779_exc_T13", "type": "Condition", "text": [ "fetal anomalies" ], "offsets": [ [ 268, 283 ] ], "normalized": [] }, { "id": "NCT02937779_exc_T14", "type": "Condition", "text": [ "Imminent child's birth" ], "offsets": [ [ 319, 341 ] ], "normalized": [] }, { "id": "NCT02937779_exc_T15", "type": "Measurement", "text": [ "cervix dilatation" ], "offsets": [ [ 353, 370 ] ], "normalized": [] }, { "id": "NCT02937779_exc_T16", "type": "Value", "text": [ "7 centimeters" ], "offsets": [ [ 377, 390 ] ], "normalized": [] } ]

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[ { "id": "NCT02937779_exc_R1", "type": "Has_negation", "arg1_id": "NCT02937779_exc_T1", "arg2_id": "NCT02937779_exc_T2", "normalized": [] }, { "id": "NCT02937779_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02937779_exc_T3", "arg2_id": "NCT02937779_exc_T5", "normalized": [] }, { "id": "NCT02937779_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02937779_exc_T4", "arg2_id": "NCT02937779_exc_T6", "normalized": [] }, { "id": "NCT02937779_exc_R4", "type": "Has_value", "arg1_id": "NCT02937779_exc_T8", "arg2_id": "NCT02937779_exc_T9", "normalized": [] }, { "id": "NCT02937779_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02937779_exc_T10", "arg2_id": "NCT02937779_exc_T11", "normalized": [] }, { "id": "NCT02937779_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02937779_exc_T10", "arg2_id": "NCT02937779_exc_T12", "normalized": [] }, { "id": "NCT02937779_exc_R7", "type": "Has_value", "arg1_id": "NCT02937779_exc_T15", "arg2_id": "NCT02937779_exc_T16", "normalized": [] }, { "id": "NCT02937779_exc_R8", "type": "AND", "arg1_id": "NCT02937779_exc_T14", "arg2_id": "NCT02937779_exc_T15", "normalized": [] } ]

[ { "id": "NCT02937779_inc_text", "type": "inclusion", "text": [ ">= 18 years old the day of inclusion\nPregnancy\nPositive HBs Ag\nInformed consent obtained with information sheet given and explained and the consent form signed by the participant of the project investigator at the latest the day of the inclusion\n" ], "offsets": [ [ 0, 246 ] ] } ]

[ { "id": "NCT02937779_inc_T1", "type": "Person", "text": [ "old" ], "offsets": [ [ 12, 15 ] ], "normalized": [] }, { "id": "NCT02937779_inc_T2", "type": "Value", "text": [ ">= 18 years" ], "offsets": [ [ 0, 11 ] ], "normalized": [] }, { "id": "NCT02937779_inc_T3", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 37, 46 ] ], "normalized": [] }, { "id": "NCT02937779_inc_T4", "type": "Measurement", "text": [ "HBs Ag" ], "offsets": [ [ 56, 62 ] ], "normalized": [] }, { "id": "NCT02937779_inc_T5", "type": "Value", "text": [ "Positive" ], "offsets": [ [ 47, 55 ] ], "normalized": [] } ]

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[ { "id": "NCT02937779_inc_R1", "type": "Has_value", "arg1_id": "NCT02937779_inc_T1", "arg2_id": "NCT02937779_inc_T2", "normalized": [] }, { "id": "NCT02937779_inc_R2", "type": "Has_value", "arg1_id": "NCT02937779_inc_T4", "arg2_id": "NCT02937779_inc_T5", "normalized": [] } ]

[ { "id": "NCT02939209_exc_text", "type": "exclusion", "text": [ "Allergy, sensitivity, or absolute contraindications to any of the medications involved in the study\npreexisting CNS depression, or taking regularly medication that cause CNS depression\npreexisting cognitive deficits, dementia, or delirium\nsevere respiratory comorbidities (e.g. chronic obstructive pulmonary disease, pneumonia, respiratory failure)\nsleep disordered breathing (diagnosed OSA, obesity hypoventilation syndrome)\npregnancy and breast feeding\nhistory of chronic pain or regular (at least once daily) opioid use preoperatively\nrenal impairment - CrCl =60 mL/minute\nnot fluent in English to be able to participate in the study process, including consent and phone interview\nBody Mass Index >35\ninability to take oral medication.\n" ], "offsets": [ [ 0, 739 ] ] } ]

[ { "id": "NCT02939209_exc_T1", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T2", "type": "Condition", "text": [ "sensitivity" ], "offsets": [ [ 9, 20 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T3", "type": "Condition", "text": [ "contraindications" ], "offsets": [ [ 34, 51 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T4", "type": "Drug", "text": [ "medications" ], "offsets": [ [ 66, 77 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T5", "type": "Qualifier", "text": [ "study" ], "offsets": [ [ 94, 99 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T6", "type": "Scope", "text": [ "Allergy, sensitivity, or absolute contraindications" ], "offsets": [ [ 0, 51 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T7", "type": "Condition", "text": [ "CNS depression" ], "offsets": [ [ 112, 126 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T8", "type": "Drug", "text": [ "medication" ], "offsets": [ [ 148, 158 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T9", "type": "Condition", "text": [ "CNS depression" ], "offsets": [ [ 170, 184 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T10", "type": "Condition", "text": [ "cognitive deficits" ], "offsets": [ [ 197, 215 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T11", "type": "Condition", "text": [ "dementia" ], "offsets": [ [ 217, 225 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T12", "type": "Condition", "text": [ "delirium" ], "offsets": [ [ 230, 238 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T13", "type": "Condition", "text": [ "respiratory comorbidities" ], "offsets": [ [ 246, 271 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T14", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 239, 245 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T15", "type": "Condition", "text": [ "chronic obstructive pulmonary disease" ], "offsets": [ [ 278, 315 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T16", "type": "Condition", "text": [ "pneumonia" ], "offsets": [ [ 317, 326 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T17", "type": "Condition", "text": [ "respiratory failure" ], "offsets": [ [ 328, 347 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T18", "type": "Scope", "text": [ "chronic obstructive pulmonary disease, pneumonia, respiratory failure" ], "offsets": [ [ 278, 347 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T19", "type": "Condition", "text": [ "sleep disordered breathing" ], "offsets": [ [ 349, 375 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T20", "type": "Condition", "text": [ "OSA" ], "offsets": [ [ 387, 390 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T21", "type": "Condition", "text": [ "obesity hypoventilation syndrome" ], "offsets": [ [ 392, 424 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T22", "type": "Scope", "text": [ "OSA, obesity hypoventilation syndrome" ], "offsets": [ [ 387, 424 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T24", "type": "Condition", "text": [ "chronic pain" ], "offsets": [ [ 466, 478 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T25", "type": "Drug", "text": [ "opioid" ], "offsets": [ [ 512, 518 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T26", "type": "Multiplier", "text": [ "at least once daily" ], "offsets": [ [ 491, 510 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T27", "type": "Qualifier", "text": [ "preoperatively" ], "offsets": [ [ 523, 537 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T28", "type": "Condition", "text": [ "renal impairment" ], "offsets": [ [ 538, 554 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T29", "type": "Measurement", "text": [ "CrCl" ], "offsets": [ [ 557, 561 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T30", "type": "Value", "text": [ "=60 mL/minute" ], "offsets": [ [ 562, 575 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T32", "type": "Measurement", "text": [ "Body Mass Index" ], "offsets": [ [ 684, 699 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T33", "type": "Value", "text": [ ">35" ], "offsets": [ [ 700, 703 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T34", "type": "Mood", "text": [ "inability" ], "offsets": [ [ 704, 713 ] ], "normalized": [] }, { "id": "NCT02939209_exc_T35", "type": "Drug", "text": [ "oral medication" ], "offsets": [ [ 722, 737 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02939209_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02939209_exc_T4", "arg2_id": "NCT02939209_exc_T5", "normalized": [] }, { "id": "NCT02939209_exc_R2", "type": "AND", "arg1_id": "NCT02939209_exc_T6", "arg2_id": "NCT02939209_exc_T4", "normalized": [] }, { "id": "NCT02939209_exc_R3", "type": "AND", "arg1_id": "NCT02939209_exc_T9", "arg2_id": "NCT02939209_exc_T8", "normalized": [] }, { "id": "NCT02939209_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT02939209_exc_T13", "arg2_id": "NCT02939209_exc_T14", "normalized": [] }, { "id": "NCT02939209_exc_R5", "type": "Subsumes", "arg1_id": "NCT02939209_exc_T13", "arg2_id": "NCT02939209_exc_T18", "normalized": [] }, { "id": "NCT02939209_exc_R6", "type": "Subsumes", "arg1_id": "NCT02939209_exc_T19", "arg2_id": "NCT02939209_exc_T22", "normalized": [] }, { "id": "NCT02939209_exc_R7", "type": "Has_multiplier", "arg1_id": "NCT02939209_exc_T25", "arg2_id": "NCT02939209_exc_T26", "normalized": [] }, { "id": "NCT02939209_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT02939209_exc_T25", "arg2_id": "NCT02939209_exc_T27", "normalized": [] }, { "id": "NCT02939209_exc_R9", "type": "AND", "arg1_id": "NCT02939209_exc_T28", "arg2_id": "NCT02939209_exc_T29", "normalized": [] }, { "id": "NCT02939209_exc_R10", "type": "Has_value", "arg1_id": "NCT02939209_exc_T29", "arg2_id": "NCT02939209_exc_T30", "normalized": [] }, { "id": "NCT02939209_exc_R11", "type": "Has_value", "arg1_id": "NCT02939209_exc_T32", "arg2_id": "NCT02939209_exc_T33", "normalized": [] }, { "id": "NCT02939209_exc_R12", "type": "Has_mood", "arg1_id": "NCT02939209_exc_T35", "arg2_id": "NCT02939209_exc_T34", "normalized": [] } ]

[ { "id": "NCT02939209_inc_text", "type": "inclusion", "text": [ "Age 18-65\nscheduled to receive ISB and general anesthesia as a day surgery patient for rotator cuff repair and acromioplasty, as a part of planned routine care\n" ], "offsets": [ [ 0, 160 ] ] } ]

[ { "id": "NCT02939209_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02939209_inc_T2", "type": "Value", "text": [ "18-65" ], "offsets": [ [ 4, 9 ] ], "normalized": [] }, { "id": "NCT02939209_inc_T3", "type": "Procedure", "text": [ "rotator cuff repair" ], "offsets": [ [ 87, 106 ] ], "normalized": [] }, { "id": "NCT02939209_inc_T4", "type": "Procedure", "text": [ "acromioplasty" ], "offsets": [ [ 111, 124 ] ], "normalized": [] }, { "id": "NCT02939209_inc_T5", "type": "Qualifier", "text": [ "day surgery" ], "offsets": [ [ 63, 74 ] ], "normalized": [] }, { "id": "NCT02939209_inc_T6", "type": "Procedure", "text": [ "ISB" ], "offsets": [ [ 31, 34 ] ], "normalized": [] }, { "id": "NCT02939209_inc_T7", "type": "Procedure", "text": [ "general anesthesia" ], "offsets": [ [ 39, 57 ] ], "normalized": [] }, { "id": "NCT02939209_inc_T8", "type": "Scope", "text": [ "Age 18-65", "cheduled to receive ISB and general anesthesia" ], "offsets": [ [ 0, 9 ], [ 11, 57 ] ], "normalized": [] }, { "id": "NCT02939209_inc_T9", "type": "Scope", "text": [ "rotator cuff repair and acromioplasty" ], "offsets": [ [ 87, 124 ] ], "normalized": [] }, { "id": "NCT02939209_inc_T10", "type": "Scope", "text": [ "ISB and general anesthesia" ], "offsets": [ [ 31, 57 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02939209_inc_R1", "type": "Has_value", "arg1_id": "NCT02939209_inc_T1", "arg2_id": "NCT02939209_inc_T2", "normalized": [] }, { "id": "NCT02939209_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02939209_inc_T9", "arg2_id": "NCT02939209_inc_T5", "normalized": [] }, { "id": "NCT02939209_inc_R3", "type": "Has_scope", "arg1_id": "NCT02939209_inc_T9", "arg2_id": "NCT02939209_inc_T10", "normalized": [] } ]

[ { "id": "NCT02939872_exc_text", "type": "exclusion", "text": [ "Contraindication to antiplatelet therapy\nNeed to continue clopidogrel due to stroke, peripheral disease, significant carotid disease or recent acute coronary syndrome\nMajor bleeding history or bleeding diathesis\nPregnancy\n" ], "offsets": [ [ 0, 222 ] ] } ]

[ { "id": "NCT02939872_exc_T1", "type": "Condition", "text": [ "Contraindication" ], "offsets": [ [ 0, 16 ] ], "normalized": [] }, { "id": "NCT02939872_exc_T2", "type": "Drug", "text": [ "antiplatelet therapy" ], "offsets": [ [ 20, 40 ] ], "normalized": [] }, { "id": "NCT02939872_exc_T3", "type": "Multiplier", "text": [ "continue" ], "offsets": [ [ 49, 57 ] ], "normalized": [] }, { "id": "NCT02939872_exc_T4", "type": "Drug", "text": [ "clopidogrel" ], "offsets": [ [ 58, 69 ] ], "normalized": [] }, { "id": "NCT02939872_exc_T5", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 77, 83 ] ], "normalized": [] }, { "id": "NCT02939872_exc_T6", "type": "Condition", "text": [ "peripheral disease" ], "offsets": [ [ 85, 103 ] ], "normalized": [] }, { "id": "NCT02939872_exc_T7", "type": "Qualifier", "text": [ "significant" ], "offsets": [ [ 105, 116 ] ], "normalized": [] }, { "id": "NCT02939872_exc_T8", "type": "Condition", "text": [ "carotid disease" ], "offsets": [ [ 117, 132 ] ], "normalized": [] }, { "id": "NCT02939872_exc_T9", "type": "Temporal", "text": [ "recent" ], "offsets": [ [ 136, 142 ] ], "normalized": [] }, { "id": "NCT02939872_exc_T10", "type": "Condition", "text": [ "acute coronary syndrome" ], "offsets": [ [ 143, 166 ] ], "normalized": [] }, { "id": "NCT02939872_exc_T11", "type": "Mood", "text": [ "Need to" ], "offsets": [ [ 41, 48 ] ], "normalized": [] }, { "id": "NCT02939872_exc_T12", "type": "Scope", "text": [ "stroke, peripheral disease, significant carotid disease or recent acute coronary syndrome" ], "offsets": [ [ 77, 166 ] ], "normalized": [] }, { "id": "NCT02939872_exc_T13", "type": "Scope", "text": [ "Need to continue clopidogrel" ], "offsets": [ [ 41, 69 ] ], "normalized": [] }, { "id": "NCT02939872_exc_T14", "type": "Qualifier", "text": [ "Major" ], "offsets": [ [ 167, 172 ] ], "normalized": [] }, { "id": "NCT02939872_exc_T15", "type": "Observation", "text": [ "history" ], "offsets": [ [ 182, 189 ] ], "normalized": [] }, { "id": "NCT02939872_exc_T16", "type": "Condition", "text": [ "bleeding" ], "offsets": [ [ 173, 181 ] ], "normalized": [] }, { "id": "NCT02939872_exc_T17", "type": "Condition", "text": [ "bleeding diathesis" ], "offsets": [ [ 193, 211 ] ], "normalized": [] }, { "id": "NCT02939872_exc_T18", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 212, 221 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02939872_exc_R1", "type": "AND", "arg1_id": "NCT02939872_exc_T1", "arg2_id": "NCT02939872_exc_T2", "normalized": [] }, { "id": "NCT02939872_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02939872_exc_T10", "arg2_id": "NCT02939872_exc_T9", "normalized": [] }, { "id": "NCT02939872_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02939872_exc_T8", "arg2_id": "NCT02939872_exc_T7", "normalized": [] }, { "id": "NCT02939872_exc_R4", "type": "Has_mood", "arg1_id": "NCT02939872_exc_T3", "arg2_id": "NCT02939872_exc_T11", "normalized": [] }, { "id": "NCT02939872_exc_R5", "type": "Has_multiplier", "arg1_id": "NCT02939872_exc_T4", "arg2_id": "NCT02939872_exc_T3", "normalized": [] }, { "id": "NCT02939872_exc_R6", "type": "Has_scope", "arg1_id": "NCT02939872_exc_T13", "arg2_id": "NCT02939872_exc_T12", "normalized": [] }, { "id": "NCT02939872_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT02939872_exc_T16", "arg2_id": "NCT02939872_exc_T14", "normalized": [] }, { "id": "NCT02939872_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02939872_exc_T16", "arg2_id": "NCT02939872_exc_T15", "normalized": [] } ]

[ { "id": "NCT02939872_inc_text", "type": "inclusion", "text": [ "Age 19 and more\nOn dual or triple antiplatelet therapy and between 12months and 14months from Bioresorbable Vascular Scaffold implantation\nNo history of death, serious myocardial infarction, stroke, repeat revascularization, or major bleeding\n" ], "offsets": [ [ 0, 243 ] ] } ]

[ { "id": "NCT02939872_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02939872_inc_T2", "type": "Value", "text": [ "19 and more" ], "offsets": [ [ 4, 15 ] ], "normalized": [] }, { "id": "NCT02939872_inc_T3", "type": "Procedure", "text": [ "triple antiplatelet therapy" ], "offsets": [ [ 27, 54 ] ], "normalized": [] }, { "id": "NCT02939872_inc_T4", "type": "Procedure", "text": [ "ual", "ntiplatelet therapy" ], "offsets": [ [ 20, 23 ], [ 35, 54 ] ], "normalized": [] }, { "id": "NCT02939872_inc_T5", "type": "Temporal", "text": [ "between 12months and 14months from Bioresorbable Vascular Scaffold implantation" ], "offsets": [ [ 59, 138 ] ], "normalized": [] }, { "id": "NCT02939872_inc_T6", "type": "Device", "text": [ "Bioresorbable Vascular Scaffold" ], "offsets": [ [ 94, 125 ] ], "normalized": [] }, { "id": "NCT02939872_inc_T7", "type": "Procedure", "text": [ "implantation" ], "offsets": [ [ 126, 138 ] ], "normalized": [] }, { "id": "NCT02939872_inc_T8", "type": "Reference_point", "text": [ "Bioresorbable Vascular Scaffold implantation" ], "offsets": [ [ 94, 138 ] ], "normalized": [] }, { "id": "NCT02939872_inc_T9", "type": "Scope", "text": [ "dual or triple antiplatelet therapy" ], "offsets": [ [ 19, 54 ] ], "normalized": [] }, { "id": "NCT02939872_inc_T10", "type": "Negation", "text": [ "No" ], "offsets": [ [ 139, 141 ] ], "normalized": [] }, { "id": "NCT02939872_inc_T11", "type": "Observation", "text": [ "history" ], "offsets": [ [ 142, 149 ] ], "normalized": [] }, { "id": "NCT02939872_inc_T12", "type": "Condition", "text": [ "death" ], "offsets": [ [ 153, 158 ] ], "normalized": [] }, { "id": "NCT02939872_inc_T13", "type": "Qualifier", "text": [ "serious" ], "offsets": [ [ 160, 167 ] ], "normalized": [] }, { "id": "NCT02939872_inc_T14", "type": "Condition", "text": [ "myocardial infarction" ], "offsets": [ [ 168, 189 ] ], "normalized": [] }, { "id": "NCT02939872_inc_T15", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 191, 197 ] ], "normalized": [] }, { "id": "NCT02939872_inc_T16", "type": "Multiplier", "text": [ "repeat" ], "offsets": [ [ 199, 205 ] ], "normalized": [] }, { "id": "NCT02939872_inc_T17", "type": "Procedure", "text": [ "revascularization" ], "offsets": [ [ 206, 223 ] ], "normalized": [] }, { "id": "NCT02939872_inc_T18", "type": "Qualifier", "text": [ "major" ], "offsets": [ [ 228, 233 ] ], "normalized": [] }, { "id": "NCT02939872_inc_T19", "type": "Condition", "text": [ "bleeding" ], "offsets": [ [ 234, 242 ] ], "normalized": [] }, { "id": "NCT02939872_inc_T20", "type": "Scope", "text": [ "death, serious myocardial infarction, stroke, repeat revascularization, or major bleeding" ], "offsets": [ [ 153, 242 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02939872_inc_R1", "type": "Has_value", "arg1_id": "NCT02939872_inc_T1", "arg2_id": "NCT02939872_inc_T2", "normalized": [] }, { "id": "NCT02939872_inc_R2", "type": "AND", "arg1_id": "NCT02939872_inc_T7", "arg2_id": "NCT02939872_inc_T6", "normalized": [] }, { "id": "NCT02939872_inc_R4", "type": "Has_index", "arg1_id": "NCT02939872_inc_T5", "arg2_id": "NCT02939872_inc_T8", "normalized": [] }, { "id": "NCT02939872_inc_R5", "type": "Has_temporal", "arg1_id": "NCT02939872_inc_T9", "arg2_id": "NCT02939872_inc_T5", "normalized": [] }, { "id": "NCT02939872_inc_R6", "type": "Has_qualifier", "arg1_id": "NCT02939872_inc_T19", "arg2_id": "NCT02939872_inc_T18", "normalized": [] }, { "id": "NCT02939872_inc_R7", "type": "Has_multiplier", "arg1_id": "NCT02939872_inc_T17", "arg2_id": "NCT02939872_inc_T16", "normalized": [] }, { "id": "NCT02939872_inc_R8", "type": "Has_qualifier", "arg1_id": "NCT02939872_inc_T14", "arg2_id": "NCT02939872_inc_T13", "normalized": [] }, { "id": "NCT02939872_inc_R9", "type": "Has_negation", "arg1_id": "NCT02939872_inc_T20", "arg2_id": "NCT02939872_inc_T10", "normalized": [] }, { "id": "NCT02939872_inc_R10", "type": "Has_temporal", "arg1_id": "NCT02939872_inc_T20", "arg2_id": "NCT02939872_inc_T11", "normalized": [] } ]

[ { "id": "NCT02940912_exc_text", "type": "exclusion", "text": [ "Atypical Parkinsonian Syndromes\nParkinson's disease with hallucinations\nParkinson's disease with impulse Control disorder (ICD)\nParkinson's disease already treated with APOMORPHINE pump or justifying the use of the pump continuously day and night\nAnother obvious severe disease explaining insomnia\nExclusion for monitoring difficulties (mutation, insufficient motivation, priority associated pathology in care)\nPatient unwilling to accept a pump\nPatient not accepting polysomnography and multiple sleep latency test\nPatient with health problems or a skin disease precluding continuous subcutaneous infusion\nFemale parturient or nursing\nCardiac dysrhythmia precluding treatment with domperidone or apomorphine (increased QTc = 440 ms in men, QTc = 450 ms in women)\nantiemetic neuroleptics\nTetrabenazine\nExcessive alcohol consumption\nHypersensitivity to apomorphine or one of the excipients\nRespiratory Depression\nHepatic impairment\nIntellectual Disability\nDementia\n" ], "offsets": [ [ 0, 964 ] ] } ]

[ { "id": "NCT02940912_exc_T1", "type": "Qualifier", "text": [ "Atypical" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T2", "type": "Condition", "text": [ "Parkinsonian Syndromes" ], "offsets": [ [ 9, 31 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T3", "type": "Condition", "text": [ "Parkinson's disease" ], "offsets": [ [ 32, 51 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T4", "type": "Condition", "text": [ "hallucinations" ], "offsets": [ [ 57, 71 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T5", "type": "Condition", "text": [ "Parkinson's disease" ], "offsets": [ [ 72, 91 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T6", "type": "Condition", "text": [ "impulse Control disorder (ICD)" ], "offsets": [ [ 97, 127 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T7", "type": "Condition", "text": [ "Parkinson's disease" ], "offsets": [ [ 128, 147 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T8", "type": "Drug", "text": [ "APOMORPHINE" ], "offsets": [ [ 169, 180 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T10", "type": "Condition", "text": [ "severe disease" ], "offsets": [ [ 263, 277 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T11", "type": "Condition", "text": [ "insomnia" ], "offsets": [ [ 289, 297 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T13", "type": "Mood", "text": [ "unwilling to accept" ], "offsets": [ [ 419, 438 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T14", "type": "Negation", "text": [ "unwilling" ], "offsets": [ [ 419, 428 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T15", "type": "Device", "text": [ "pump" ], "offsets": [ [ 441, 445 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T16", "type": "Procedure", "text": [ "polysomnography" ], "offsets": [ [ 468, 483 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T17", "type": "Mood", "text": [ "not accepting" ], "offsets": [ [ 454, 467 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T18", "type": "Negation", "text": [ "not" ], "offsets": [ [ 454, 457 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T19", "type": "Procedure", "text": [ "multiple sleep latency test" ], "offsets": [ [ 488, 515 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T20", "type": "Condition", "text": [ "health problems" ], "offsets": [ [ 529, 544 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T21", "type": "Condition", "text": [ "skin disease" ], "offsets": [ [ 550, 562 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T22", "type": "Negation", "text": [ "precluding" ], "offsets": [ [ 563, 573 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T23", "type": "Procedure", "text": [ "continuous subcutaneous infusion" ], "offsets": [ [ 574, 606 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T24", "type": "Scope", "text": [ "health problems or a skin disease" ], "offsets": [ [ 529, 562 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T25", "type": "Person", "text": [ "Female" ], "offsets": [ [ 607, 613 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T26", "type": "Condition", "text": [ "parturient" ], "offsets": [ [ 614, 624 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T27", "type": "Condition", "text": [ "nursing" ], "offsets": [ [ 628, 635 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T28", "type": "Condition", "text": [ "Cardiac dysrhythmia" ], "offsets": [ [ 636, 655 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T29", "type": "Drug", "text": [ "domperidone" ], "offsets": [ [ 682, 693 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T30", "type": "Drug", "text": [ "apomorphine" ], "offsets": [ [ 697, 708 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T31", "type": "Negation", "text": [ "precluding" ], "offsets": [ [ 656, 666 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T32", "type": "Scope", "text": [ "domperidone or apomorphine" ], "offsets": [ [ 682, 708 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T33", "type": "Scope", "text": [ "precluding treatment with domperidone or apomorphine" ], "offsets": [ [ 656, 708 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T34", "type": "Measurement", "text": [ "QTc" ], "offsets": [ [ 720, 723 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T36", "type": "Value", "text": [ "= 440 ms" ], "offsets": [ [ 724, 732 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T37", "type": "Measurement", "text": [ "QTc" ], "offsets": [ [ 741, 744 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T38", "type": "Value", "text": [ "= 450 ms" ], "offsets": [ [ 745, 753 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T39", "type": "Person", "text": [ "women" ], "offsets": [ [ 757, 762 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T40", "type": "Person", "text": [ "men" ], "offsets": [ [ 736, 739 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T35", "type": "Scope", "text": [ "QTc = 440 ms in men, QTc = 450 ms in women" ], "offsets": [ [ 720, 762 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T41", "type": "Drug", "text": [ "antiemetic neuroleptics" ], "offsets": [ [ 764, 787 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T42", "type": "Drug", "text": [ "Tetrabenazine" ], "offsets": [ [ 788, 801 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T43", "type": "Condition", "text": [ "Excessive alcohol consumption" ], "offsets": [ [ 802, 831 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T44", "type": "Condition", "text": [ "Hypersensitivity" ], "offsets": [ [ 832, 848 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T45", "type": "Drug", "text": [ "apomorphine" ], "offsets": [ [ 852, 863 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T46", "type": "Drug", "text": [ "excipients" ], "offsets": [ [ 878, 888 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T47", "type": "Scope", "text": [ "apomorphine or one of the excipients" ], "offsets": [ [ 852, 888 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T48", "type": "Condition", "text": [ "Respiratory Depression" ], "offsets": [ [ 889, 911 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T49", "type": "Condition", "text": [ "Hepatic impairment" ], "offsets": [ [ 912, 930 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T50", "type": "Condition", "text": [ "Intellectual Disability" ], "offsets": [ [ 931, 954 ] ], "normalized": [] }, { "id": "NCT02940912_exc_T51", "type": "Condition", "text": [ "Dementia" ], "offsets": [ [ 955, 963 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02940912_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02940912_exc_T2", "arg2_id": "NCT02940912_exc_T1", "normalized": [] }, { "id": "NCT02940912_exc_R3", "type": "AND", "arg1_id": "NCT02940912_exc_T5", "arg2_id": "NCT02940912_exc_T6", "normalized": [] }, { "id": "NCT02940912_exc_R4", "type": "AND", "arg1_id": "NCT02940912_exc_T7", "arg2_id": "NCT02940912_exc_T8", "normalized": [] }, { "id": "NCT02940912_exc_R5", "type": "AND", "arg1_id": "NCT02940912_exc_T10", "arg2_id": "NCT02940912_exc_T11", "normalized": [] }, { "id": "NCT02940912_exc_R6", "type": "Has_mood", "arg1_id": "NCT02940912_exc_T15", "arg2_id": "NCT02940912_exc_T13", "normalized": [] }, { "id": "NCT02940912_exc_R7", "type": "Has_mood", "arg1_id": "NCT02940912_exc_T16", "arg2_id": "NCT02940912_exc_T17", "normalized": [] }, { "id": "NCT02940912_exc_R8", "type": "Has_mood", "arg1_id": "NCT02940912_exc_T19", "arg2_id": "NCT02940912_exc_T17", "normalized": [] }, { "id": "NCT02940912_exc_R9", "type": "Has_negation", "arg1_id": "NCT02940912_exc_T23", "arg2_id": "NCT02940912_exc_T22", "normalized": [] }, { "id": "NCT02940912_exc_R10", "type": "AND", "arg1_id": "NCT02940912_exc_T24", "arg2_id": "NCT02940912_exc_T23", "normalized": [] }, { "id": "NCT02940912_exc_R11", "type": "Has_negation", "arg1_id": "NCT02940912_exc_T32", "arg2_id": "NCT02940912_exc_T31", "normalized": [] }, { "id": "NCT02940912_exc_R12", "type": "Has_scope", "arg1_id": "NCT02940912_exc_T28", "arg2_id": "NCT02940912_exc_T33", "normalized": [] }, { "id": "NCT02940912_exc_R13", "type": "Has_value", "arg1_id": "NCT02940912_exc_T34", "arg2_id": "NCT02940912_exc_T36", "normalized": [] }, { "id": "NCT02940912_exc_R14", "type": "Has_value", "arg1_id": "NCT02940912_exc_T37", "arg2_id": "NCT02940912_exc_T38", "normalized": [] }, { "id": "NCT02940912_exc_R15", "type": "AND", "arg1_id": "NCT02940912_exc_T40", "arg2_id": "NCT02940912_exc_T34", "normalized": [] }, { "id": "NCT02940912_exc_R16", "type": "AND", "arg1_id": "NCT02940912_exc_T39", "arg2_id": "NCT02940912_exc_T37", "normalized": [] }, { "id": "NCT02940912_exc_R17", "type": "Subsumes", "arg1_id": "NCT02940912_exc_T28", "arg2_id": "NCT02940912_exc_T35", "normalized": [] }, { "id": "NCT02940912_exc_R18", "type": "Has_scope", "arg1_id": "NCT02940912_exc_T44", "arg2_id": "NCT02940912_exc_T47", "normalized": [] }, { "id": "NCT02940912_exc_R2", "type": "AND", "arg1_id": "NCT02940912_exc_T3", "arg2_id": "NCT02940912_exc_T4", "normalized": [] } ]

[ { "id": "NCT02940912_inc_text", "type": "inclusion", "text": [ "Idiopathic Parkinson's disease ( Hughes AJ et al. 2001)\nPatients with motor fluctuations\nChronic Insomnia disorder criteria according to the criteria of DMS- V ( American Psychiatric Association, 2013) and insomnia severity index > 15\nAble to use independently the device required for treatment by apomorphine\nCollection of written informed consent (legal obligation for any project under the public health law , bioethics laws and / or CNIL) .\nAffiliate to social security or beneficiary of such a regime\n" ], "offsets": [ [ 0, 506 ] ] } ]

[ { "id": "NCT02940912_inc_T1", "type": "Condition", "text": [ "Parkinson's disease" ], "offsets": [ [ 11, 30 ] ], "normalized": [] }, { "id": "NCT02940912_inc_T2", "type": "Qualifier", "text": [ "Idiopathic" ], "offsets": [ [ 0, 10 ] ], "normalized": [] }, { "id": "NCT02940912_inc_T3", "type": "Condition", "text": [ "motor fluctuations" ], "offsets": [ [ 70, 88 ] ], "normalized": [] }, { "id": "NCT02940912_inc_T4", "type": "Condition", "text": [ "Chronic Insomnia disorder" ], "offsets": [ [ 89, 114 ] ], "normalized": [] }, { "id": "NCT02940912_inc_T5", "type": "Qualifier", "text": [ "criteria of DMS- V" ], "offsets": [ [ 141, 159 ] ], "normalized": [] }, { "id": "NCT02940912_inc_T6", "type": "Measurement", "text": [ "insomnia severity index" ], "offsets": [ [ 206, 229 ] ], "normalized": [] }, { "id": "NCT02940912_inc_T7", "type": "Value", "text": [ "> 15" ], "offsets": [ [ 230, 234 ] ], "normalized": [] }, { "id": "NCT02940912_inc_T8", "type": "Drug", "text": [ "apomorphine" ], "offsets": [ [ 298, 309 ] ], "normalized": [] }, { "id": "NCT02940912_inc_T9", "type": "Device", "text": [ "device" ], "offsets": [ [ 265, 271 ] ], "normalized": [] }, { "id": "NCT02940912_inc_T11", "type": "Person", "text": [ "Affiliate to social security" ], "offsets": [ [ 445, 473 ] ], "normalized": [] }, { "id": "NCT02940912_inc_T12", "type": "Person", "text": [ "l security or b", "iciary of s" ], "offsets": [ [ 463, 478 ], [ 482, 493 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02940912_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT02940912_inc_T1", "arg2_id": "NCT02940912_inc_T2", "normalized": [] }, { "id": "NCT02940912_inc_R2", "type": "Has_value", "arg1_id": "NCT02940912_inc_T6", "arg2_id": "NCT02940912_inc_T7", "normalized": [] }, { "id": "NCT02940912_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT02940912_inc_T4", "arg2_id": "NCT02940912_inc_T5", "normalized": [] }, { "id": "NCT02940912_inc_R4", "type": "AND", "arg1_id": "NCT02940912_inc_T4", "arg2_id": "NCT02940912_inc_T6", "normalized": [] }, { "id": "NCT02940912_inc_R5", "type": "AND", "arg1_id": "NCT02940912_inc_T8", "arg2_id": "NCT02940912_inc_T9", "normalized": [] } ]

[ { "id": "NCT02942303_exc_text", "type": "exclusion", "text": [ "Patients with previous periorbital/forehead surgery\nPatients who plucked the upper eyebrow margin\nPatients with eyebrow tatoos\nPatients with upper face botulinum toxin injection in the past 12 months\nPatients with resorbable upper face fillers injection in the past 12 months\nPatients with previous permanent upper face fillers injection\nPregnant patients\nLactating patients\nPatients with preexisting neuromuscular conditions (myasthenia gravis, Eaton Lambert syndrome)\nPatients using medication that could potentiate the effect of botulinum (ex: aminoglycoside antibiotics)\nPatients with sensitivity to botulinum toxin or human albumin\n" ], "offsets": [ [ 0, 637 ] ] } ]

[ { "id": "NCT02942303_exc_T1", "type": "Procedure", "text": [ "forehead surgery" ], "offsets": [ [ 35, 51 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T2", "type": "Procedure", "text": [ "periorbital", "surgery" ], "offsets": [ [ 23, 34 ], [ 44, 51 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T3", "type": "Condition", "text": [ "plucked the upper eyebrow margin" ], "offsets": [ [ 65, 97 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T4", "type": "Observation", "text": [ "eyebrow tatoos" ], "offsets": [ [ 112, 126 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T5", "type": "Procedure", "text": [ "botulinum toxin injection" ], "offsets": [ [ 152, 177 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T6", "type": "Qualifier", "text": [ "upper face" ], "offsets": [ [ 141, 151 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T7", "type": "Temporal", "text": [ "in the past 12 months" ], "offsets": [ [ 178, 199 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T8", "type": "Temporal", "text": [ "in the past 12 months" ], "offsets": [ [ 254, 275 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T9", "type": "Procedure", "text": [ "rbable upp", "ers injection in" ], "offsets": [ [ 218, 228 ], [ 240, 256 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T10", "type": "Qualifier", "text": [ "upper face" ], "offsets": [ [ 225, 235 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T11", "type": "Procedure", "text": [ "nent uppe", "rs injection\nPreg" ], "offsets": [ [ 304, 313 ], [ 325, 342 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T12", "type": "Qualifier", "text": [ "upper face" ], "offsets": [ [ 309, 319 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T13", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 338, 346 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T14", "type": "Condition", "text": [ "Lactating" ], "offsets": [ [ 356, 365 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T15", "type": "Condition", "text": [ "neuromuscular conditions" ], "offsets": [ [ 401, 425 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T16", "type": "Condition", "text": [ "myasthenia gravis" ], "offsets": [ [ 427, 444 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T17", "type": "Condition", "text": [ "Eaton Lambert syndrome" ], "offsets": [ [ 446, 468 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T18", "type": "Scope", "text": [ "myasthenia gravis, Eaton Lambert syndrome" ], "offsets": [ [ 427, 468 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T19", "type": "Drug", "text": [ "botulinum" ], "offsets": [ [ 532, 541 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T20", "type": "Condition", "text": [ "potentiate the effect" ], "offsets": [ [ 507, 528 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T21", "type": "Drug", "text": [ "medication" ], "offsets": [ [ 485, 495 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T22", "type": "Drug", "text": [ "aminoglycoside antibiotics" ], "offsets": [ [ 547, 573 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T23", "type": "Scope", "text": [ "medication that could potentiate the effect of botulinum" ], "offsets": [ [ 485, 541 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T24", "type": "Drug", "text": [ "botulinum toxin" ], "offsets": [ [ 604, 619 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T25", "type": "Drug", "text": [ "human albumin" ], "offsets": [ [ 623, 636 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T26", "type": "Condition", "text": [ "sensitivity" ], "offsets": [ [ 589, 600 ] ], "normalized": [] }, { "id": "NCT02942303_exc_T27", "type": "Scope", "text": [ "botulinum toxin or human albumin" ], "offsets": [ [ 604, 636 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02942303_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02942303_exc_T5", "arg2_id": "NCT02942303_exc_T6", "normalized": [] }, { "id": "NCT02942303_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02942303_exc_T5", "arg2_id": "NCT02942303_exc_T7", "normalized": [] }, { "id": "NCT02942303_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02942303_exc_T9", "arg2_id": "NCT02942303_exc_T10", "normalized": [] }, { "id": "NCT02942303_exc_R4", "type": "Has_temporal", "arg1_id": "NCT02942303_exc_T9", "arg2_id": "NCT02942303_exc_T8", "normalized": [] }, { "id": "NCT02942303_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02942303_exc_T11", "arg2_id": "NCT02942303_exc_T12", "normalized": [] }, { "id": "NCT02942303_exc_R6", "type": "Subsumes", "arg1_id": "NCT02942303_exc_T15", "arg2_id": "NCT02942303_exc_T18", "normalized": [] }, { "id": "NCT02942303_exc_R7", "type": "AND", "arg1_id": "NCT02942303_exc_T21", "arg2_id": "NCT02942303_exc_T20", "normalized": [] }, { "id": "NCT02942303_exc_R8", "type": "AND", "arg1_id": "NCT02942303_exc_T20", "arg2_id": "NCT02942303_exc_T19", "normalized": [] }, { "id": "NCT02942303_exc_R9", "type": "Subsumes", "arg1_id": "NCT02942303_exc_T23", "arg2_id": "NCT02942303_exc_T22", "normalized": [] }, { "id": "NCT02942303_exc_R10", "type": "Has_scope", "arg1_id": "NCT02942303_exc_T26", "arg2_id": "NCT02942303_exc_T27", "normalized": [] } ]

[ { "id": "NCT02942303_inc_text", "type": "inclusion", "text": [ "Consecutive 30 female patients presenting to our clinic for brow lifting with botulinum toxin will be randomized to receive one of the two injection techniques\n" ], "offsets": [ [ 0, 160 ] ] } ]

[ { "id": "NCT02942303_inc_T1", "type": "Procedure", "text": [ "brow lifting" ], "offsets": [ [ 60, 72 ] ], "normalized": [] }, { "id": "NCT02942303_inc_T2", "type": "Drug", "text": [ "botulinum toxin" ], "offsets": [ [ 78, 93 ] ], "normalized": [] }, { "id": "NCT02942303_inc_T3", "type": "Person", "text": [ "female" ], "offsets": [ [ 15, 21 ] ], "normalized": [] }, { "id": "NCT02942303_inc_T4", "type": "Multiplier", "text": [ "30" ], "offsets": [ [ 12, 14 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02942303_inc_R1", "type": "AND", "arg1_id": "NCT02942303_inc_T1", "arg2_id": "NCT02942303_inc_T2", "normalized": [] }, { "id": "NCT02942303_inc_R2", "type": "Has_multiplier", "arg1_id": "NCT02942303_inc_T3", "arg2_id": "NCT02942303_inc_T4", "normalized": [] }, { "id": "NCT02942303_inc_R3", "type": "AND", "arg1_id": "NCT02942303_inc_T3", "arg2_id": "NCT02942303_inc_T1", "normalized": [] } ]

[ { "id": "NCT02944292_exc_text", "type": "exclusion", "text": [ "Contraindication for propofol administration\nContraindication for IAP measurement in supine position with head-of-bed at 0°\nOther intervention for reduction of IAP planned\nPrevious propofol infusion rate >4 mg/kg/h\n" ], "offsets": [ [ 0, 215 ] ] } ]

[ { "id": "NCT02944292_exc_T1", "type": "Condition", "text": [ "Contraindication" ], "offsets": [ [ 0, 16 ] ], "normalized": [] }, { "id": "NCT02944292_exc_T2", "type": "Drug", "text": [ "propofol" ], "offsets": [ [ 21, 29 ] ], "normalized": [] }, { "id": "NCT02944292_exc_T3", "type": "Condition", "text": [ "Contraindication" ], "offsets": [ [ 45, 61 ] ], "normalized": [] }, { "id": "NCT02944292_exc_T4", "type": "Procedure", "text": [ "IAP measurement" ], "offsets": [ [ 66, 81 ] ], "normalized": [] }, { "id": "NCT02944292_exc_T5", "type": "Qualifier", "text": [ "supine position" ], "offsets": [ [ 85, 100 ] ], "normalized": [] }, { "id": "NCT02944292_exc_T6", "type": "Qualifier", "text": [ "head-of-bed at 0°" ], "offsets": [ [ 106, 123 ] ], "normalized": [] }, { "id": "NCT02944292_exc_T7", "type": "Qualifier", "text": [ "Other" ], "offsets": [ [ 124, 129 ] ], "normalized": [] }, { "id": "NCT02944292_exc_T8", "type": "Procedure", "text": [ "intervention for reduction of IAP" ], "offsets": [ [ 130, 163 ] ], "normalized": [] }, { "id": "NCT02944292_exc_T9", "type": "Mood", "text": [ "planned" ], "offsets": [ [ 164, 171 ] ], "normalized": [] }, { "id": "NCT02944292_exc_T10", "type": "Temporal", "text": [ "Previous" ], "offsets": [ [ 172, 180 ] ], "normalized": [] }, { "id": "NCT02944292_exc_T11", "type": "Measurement", "text": [ "propofol infusion rate" ], "offsets": [ [ 181, 203 ] ], "normalized": [] }, { "id": "NCT02944292_exc_T12", "type": "Value", "text": [ ">4 mg/kg/h" ], "offsets": [ [ 204, 214 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02944292_exc_R1", "type": "AND", "arg1_id": "NCT02944292_exc_T1", "arg2_id": "NCT02944292_exc_T2", "normalized": [] }, { "id": "NCT02944292_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02944292_exc_T4", "arg2_id": "NCT02944292_exc_T5", "normalized": [] }, { "id": "NCT02944292_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02944292_exc_T4", "arg2_id": "NCT02944292_exc_T6", "normalized": [] }, { "id": "NCT02944292_exc_R4", "type": "AND", "arg1_id": "NCT02944292_exc_T3", "arg2_id": "NCT02944292_exc_T4", "normalized": [] }, { "id": "NCT02944292_exc_R5", "type": "Has_mood", "arg1_id": "NCT02944292_exc_T8", "arg2_id": "NCT02944292_exc_T9", "normalized": [] }, { "id": "NCT02944292_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02944292_exc_T8", "arg2_id": "NCT02944292_exc_T7", "normalized": [] }, { "id": "NCT02944292_exc_R7", "type": "Has_value", "arg1_id": "NCT02944292_exc_T11", "arg2_id": "NCT02944292_exc_T12", "normalized": [] }, { "id": "NCT02944292_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02944292_exc_T11", "arg2_id": "NCT02944292_exc_T10", "normalized": [] } ]

[ { "id": "NCT02944292_inc_text", "type": "inclusion", "text": [ "Age 18 years or older\nMechanical ventilation\nIAP between 12 and 20 mmHg in at least two consecutive measurements within 1-12 h\nSpontaneous breathing activity of at least 6 breaths/minute\nRASS score between 0 and -4\nPhysician-led sedation (if sedated; as opposed to nurse-led protocol)\n" ], "offsets": [ [ 0, 285 ] ] } ]

[ { "id": "NCT02944292_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02944292_inc_T2", "type": "Value", "text": [ "18 years or older" ], "offsets": [ [ 4, 21 ] ], "normalized": [] }, { "id": "NCT02944292_inc_T3", "type": "Procedure", "text": [ "Mechanical ventilation" ], "offsets": [ [ 22, 44 ] ], "normalized": [] }, { "id": "NCT02944292_inc_T4", "type": "Measurement", "text": [ "IAP" ], "offsets": [ [ 45, 48 ] ], "normalized": [] }, { "id": "NCT02944292_inc_T5", "type": "Value", "text": [ "between 12 and 20 mmHg" ], "offsets": [ [ 49, 71 ] ], "normalized": [] }, { "id": "NCT02944292_inc_T6", "type": "Multiplier", "text": [ "at least two consecutive measurements" ], "offsets": [ [ 75, 112 ] ], "normalized": [] }, { "id": "NCT02944292_inc_T7", "type": "Temporal", "text": [ "within 1-12 h" ], "offsets": [ [ 113, 126 ] ], "normalized": [] }, { "id": "NCT02944292_inc_T8", "type": "Measurement", "text": [ "Spontaneous breathing activity" ], "offsets": [ [ 127, 157 ] ], "normalized": [] }, { "id": "NCT02944292_inc_T9", "type": "Procedure", "text": [ "sedation" ], "offsets": [ [ 229, 237 ] ], "normalized": [] }, { "id": "NCT02944292_inc_T10", "type": "Qualifier", "text": [ "Physician-led" ], "offsets": [ [ 215, 228 ] ], "normalized": [] }, { "id": "NCT02944292_inc_T11", "type": "Measurement", "text": [ "RASS score" ], "offsets": [ [ 187, 197 ] ], "normalized": [] }, { "id": "NCT02944292_inc_T12", "type": "Value", "text": [ "between 0 and -4" ], "offsets": [ [ 198, 214 ] ], "normalized": [] }, { "id": "NCT02944292_inc_T13", "type": "Value", "text": [ "at least 6 breaths/minute" ], "offsets": [ [ 161, 186 ] ], "normalized": [] }, { "id": "NCT02944292_inc_T14", "type": "Negation", "text": [ "as opposed to" ], "offsets": [ [ 251, 264 ] ], "normalized": [] }, { "id": "NCT02944292_inc_T15", "type": "Qualifier", "text": [ "nurse-led protocol" ], "offsets": [ [ 265, 283 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02944292_inc_R1", "type": "Has_value", "arg1_id": "NCT02944292_inc_T1", "arg2_id": "NCT02944292_inc_T2", "normalized": [] }, { "id": "NCT02944292_inc_R2", "type": "Has_temporal", "arg1_id": "NCT02944292_inc_T6", "arg2_id": "NCT02944292_inc_T7", "normalized": [] }, { "id": "NCT02944292_inc_R3", "type": "Has_value", "arg1_id": "NCT02944292_inc_T4", "arg2_id": "NCT02944292_inc_T5", "normalized": [] }, { "id": "NCT02944292_inc_R4", "type": "Has_multiplier", "arg1_id": "NCT02944292_inc_T4", "arg2_id": "NCT02944292_inc_T6", "normalized": [] }, { "id": "NCT02944292_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT02944292_inc_T9", "arg2_id": "NCT02944292_inc_T10", "normalized": [] }, { "id": "NCT02944292_inc_R6", "type": "Has_value", "arg1_id": "NCT02944292_inc_T8", "arg2_id": "NCT02944292_inc_T13", "normalized": [] }, { "id": "NCT02944292_inc_R7", "type": "Has_qualifier", "arg1_id": "NCT02944292_inc_T10", "arg2_id": "NCT02944292_inc_T15", "normalized": [] }, { "id": "NCT02944292_inc_R8", "type": "Has_negation", "arg1_id": "NCT02944292_inc_T15", "arg2_id": "NCT02944292_inc_T14", "normalized": [] } ]

[ { "id": "NCT02944604_exc_text", "type": "exclusion", "text": [ "NA\n" ], "offsets": [ [ 0, 3 ] ] } ]

[]

[]

[]

[]

[ { "id": "NCT02944604_inc_text", "type": "inclusion", "text": [ "Severe or uncontrolled infection.\nSensitive to the product or other genetically engineered biological products from Escherichia coli strains.\nMental or nervous system disorders.\nSevere heart, lung and central nervous system disorders.\nPregnant or lactating women.\nTBIL(total bilirubin ), ALT(alanine aminotransferase),AST(glutamic-oxalacetic transaminase) > 2.5×ULN(upper limit of normal); if it were caused by liver metastases, TBIL, ALT,AST >5×ULN.\nCr(creatinine) >1.5×ULN.\n" ], "offsets": [ [ 0, 476 ] ] } ]

[ { "id": "NCT02944604_inc_T1", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T2", "type": "Qualifier", "text": [ "uncontrolled" ], "offsets": [ [ 10, 22 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T3", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 23, 32 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T4", "type": "Scope", "text": [ "Severe or uncontrolled" ], "offsets": [ [ 0, 22 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T5", "type": "Condition", "text": [ "Sensitive" ], "offsets": [ [ 34, 43 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T6", "type": "Drug", "text": [ "the product" ], "offsets": [ [ 47, 58 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T7", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 62, 67 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T8", "type": "Drug", "text": [ "genetically engineered biological products" ], "offsets": [ [ 68, 110 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T9", "type": "Qualifier", "text": [ "Escherichia coli strains" ], "offsets": [ [ 116, 140 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T10", "type": "Condition", "text": [ "ntal o", "sorders." ], "offsets": [ [ 144, 150 ], [ 169, 177 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T11", "type": "Condition", "text": [ "nervous system disorders" ], "offsets": [ [ 152, 176 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T12", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 178, 184 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T13", "type": "Condition", "text": [ "rt, l", "orders.\nP" ], "offsets": [ [ 188, 193 ], [ 227, 236 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T14", "type": "Condition", "text": [ "g an", "orders.\nP" ], "offsets": [ [ 195, 199 ], [ 227, 236 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T15", "type": "Condition", "text": [ "entral nervous system disorders" ], "offsets": [ [ 202, 233 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T16", "type": "Scope", "text": [ "heart, lung and central nervous system disorders" ], "offsets": [ [ 185, 233 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T17", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 235, 243 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T18", "type": "Condition", "text": [ "lactating" ], "offsets": [ [ 247, 256 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T19", "type": "Person", "text": [ "women" ], "offsets": [ [ 257, 262 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T20", "type": "Measurement", "text": [ "total bilirubin" ], "offsets": [ [ 269, 284 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T21", "type": "Measurement", "text": [ "TBIL" ], "offsets": [ [ 264, 268 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T22", "type": "Measurement", "text": [ "ALT" ], "offsets": [ [ 288, 291 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T23", "type": "Measurement", "text": [ "alanine aminotransferase" ], "offsets": [ [ 292, 316 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T24", "type": "Measurement", "text": [ "AST" ], "offsets": [ [ 318, 321 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T25", "type": "Measurement", "text": [ "glutamic-oxalacetic transaminase" ], "offsets": [ [ 322, 354 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T26", "type": "Value", "text": [ "> 2.5×ULN" ], "offsets": [ [ 356, 365 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T27", "type": "Condition", "text": [ "liver metastases" ], "offsets": [ [ 411, 427 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T28", "type": "Measurement", "text": [ "TBIL" ], "offsets": [ [ 429, 433 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T29", "type": "Measurement", "text": [ "ALT" ], "offsets": [ [ 435, 438 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T30", "type": "Measurement", "text": [ "AST" ], "offsets": [ [ 439, 442 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T31", "type": "Value", "text": [ ">5×ULN" ], "offsets": [ [ 443, 449 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T32", "type": "Measurement", "text": [ "Cr" ], "offsets": [ [ 451, 453 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T33", "type": "Measurement", "text": [ "creatinine" ], "offsets": [ [ 454, 464 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T34", "type": "Value", "text": [ ">1.5×ULN" ], "offsets": [ [ 466, 474 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T35", "type": "Scope", "text": [ "TBIL(total bilirubin ), ALT(alanine aminotransferase),AST(glutamic-oxalacetic transaminase) > 2.5×ULN" ], "offsets": [ [ 264, 365 ] ], "normalized": [] }, { "id": "NCT02944604_inc_T36", "type": "Scope", "text": [ "liver metastases, TBIL, ALT,AST >5×ULN" ], "offsets": [ [ 411, 449 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT02944604_inc_R1", "type": "Has_scope", "arg1_id": "NCT02944604_inc_T3", "arg2_id": "NCT02944604_inc_T4", "normalized": [] }, { "id": "NCT02944604_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02944604_inc_T8", "arg2_id": "NCT02944604_inc_T9", "normalized": [] }, { "id": "NCT02944604_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT02944604_inc_T16", "arg2_id": "NCT02944604_inc_T12", "normalized": [] }, { "id": "NCT02944604_inc_R4", "type": "Subsumes", "arg1_id": "NCT02944604_inc_T24", "arg2_id": "NCT02944604_inc_T25", "normalized": [] }, { "id": "NCT02944604_inc_R5", "type": "Subsumes", "arg1_id": "NCT02944604_inc_T22", "arg2_id": "NCT02944604_inc_T23", "normalized": [] }, { "id": "NCT02944604_inc_R6", "type": "Subsumes", "arg1_id": "NCT02944604_inc_T21", "arg2_id": "NCT02944604_inc_T20", "normalized": [] }, { "id": "NCT02944604_inc_R7", "type": "Has_value", "arg1_id": "NCT02944604_inc_T24", "arg2_id": "NCT02944604_inc_T26", "normalized": [] }, { "id": "NCT02944604_inc_R8", "type": "Has_value", "arg1_id": "NCT02944604_inc_T22", "arg2_id": "NCT02944604_inc_T26", "normalized": [] }, { "id": "NCT02944604_inc_R9", "type": "Has_value", "arg1_id": "NCT02944604_inc_T21", "arg2_id": "NCT02944604_inc_T26", "normalized": [] }, { "id": "NCT02944604_inc_R10", "type": "Has_value", "arg1_id": "NCT02944604_inc_T30", "arg2_id": "NCT02944604_inc_T31", "normalized": [] }, { "id": "NCT02944604_inc_R11", "type": "Has_value", "arg1_id": "NCT02944604_inc_T29", "arg2_id": "NCT02944604_inc_T31", "normalized": [] }, { "id": "NCT02944604_inc_R12", "type": "Has_value", "arg1_id": "NCT02944604_inc_T28", "arg2_id": "NCT02944604_inc_T31", "normalized": [] }, { "id": "NCT02944604_inc_R13", "type": "Subsumes", "arg1_id": "NCT02944604_inc_T32", "arg2_id": "NCT02944604_inc_T33", "normalized": [] }, { "id": "NCT02944604_inc_R14", "type": "Has_value", "arg1_id": "NCT02944604_inc_T32", "arg2_id": "NCT02944604_inc_T34", "normalized": [] } ]

[ { "id": "NCT02944929_exc_text", "type": "exclusion", "text": [ "Patients who are unwilling to participate in the study. For the one under guardianship, the refusal of the patient will be the final decision even if the guardian is willing to participate.\nSubjects who are unlikely to adhere to the study an/or poor adherence anticipated by the investigator.\nUn-controlled progressive pathology.\nOsteoarticular lesion which contraindicates part of the rehabilitation involved in the study.\nPatients with other interventions planned prior to the end of the study period (orthosis, surgery etc.).\nSurgery to the treated limb less than 6 months previously.\nPregnant woman.\n" ], "offsets": [ [ 0, 604 ] ] } ]

[ { "id": "NCT02944929_exc_T4", "type": "Condition", "text": [ "Osteoarticular lesion" ], "offsets": [ [ 330, 351 ] ], "normalized": [] }, { "id": "NCT02944929_exc_T7", "type": "Procedure", "text": [ "Surgery" ], "offsets": [ [ 529, 536 ] ], "normalized": [] }, { "id": "NCT02944929_exc_T8", "type": "Qualifier", "text": [ "treated limb" ], "offsets": [ [ 544, 556 ] ], "normalized": [] }, { "id": "NCT02944929_exc_T9", "type": "Temporal", "text": [ "less than 6 months" ], "offsets": [ [ 557, 575 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02944929_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02944929_exc_T7", "arg2_id": "NCT02944929_exc_T8", "normalized": [] }, { "id": "NCT02944929_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02944929_exc_T7", "arg2_id": "NCT02944929_exc_T9", "normalized": [] } ]

[ { "id": "NCT02944929_inc_text", "type": "inclusion", "text": [ "Males and females aged between 18 to 75 years.\nAdult patient under guardianship with consent obtained and the legal guardian's authorisation obtained.\nSingle stroke having occurred more than 6 months before (previous TIA is accepted).\nCapable of understanding instructions and participating in the definition of a therapeutic goal (Boston Diagnostic Aphasia Examination (BDAE) < 3).\nHaving previously undergone BTI. The last injection must have been performed at least 4 months prior to inclusion.\nAffiliation to the French social security regime or a similar regime.\nPatient (or the legal guardian if under guardian adult patient) has signed the informed consent form.\n" ], "offsets": [ [ 0, 670 ] ] } ]

[ { "id": "NCT02944929_inc_T1", "type": "Person", "text": [ "Males" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT02944929_inc_T2", "type": "Person", "text": [ "females" ], "offsets": [ [ 10, 17 ] ], "normalized": [] }, { "id": "NCT02944929_inc_T3", "type": "Person", "text": [ "aged" ], "offsets": [ [ 18, 22 ] ], "normalized": [] }, { "id": "NCT02944929_inc_T4", "type": "Value", "text": [ "between 18 to 75 years" ], "offsets": [ [ 23, 45 ] ], "normalized": [] }, { "id": "NCT02944929_inc_T6", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 158, 164 ] ], "normalized": [] }, { "id": "NCT02944929_inc_T7", "type": "Multiplier", "text": [ "Single" ], "offsets": [ [ 151, 157 ] ], "normalized": [] }, { "id": "NCT02944929_inc_T8", "type": "Temporal", "text": [ "more than 6 months" ], "offsets": [ [ 181, 199 ] ], "normalized": [] }, { "id": "NCT02944929_inc_T9", "type": "Condition", "text": [ "TIA" ], "offsets": [ [ 217, 220 ] ], "normalized": [] }, { "id": "NCT02944929_inc_T11", "type": "Measurement", "text": [ "Boston Diagnostic Aphasia Examination" ], "offsets": [ [ 332, 369 ] ], "normalized": [] }, { "id": "NCT02944929_inc_T12", "type": "Measurement", "text": [ "BDAE" ], "offsets": [ [ 371, 375 ] ], "normalized": [] }, { "id": "NCT02944929_inc_T13", "type": "Value", "text": [ "< 3" ], "offsets": [ [ 377, 380 ] ], "normalized": [] }, { "id": "NCT02944929_inc_T14", "type": "Procedure", "text": [ "BTI" ], "offsets": [ [ 411, 414 ] ], "normalized": [] }, { "id": "NCT02944929_inc_T15", "type": "Procedure", "text": [ "injection" ], "offsets": [ [ 425, 434 ] ], "normalized": [] }, { "id": "NCT02944929_inc_T16", "type": "Temporal", "text": [ "at least 4 months prior to inclusion" ], "offsets": [ [ 460, 496 ] ], "normalized": [] }, { "id": "NCT02944929_inc_T17", "type": "Reference_point", "text": [ "inclusion" ], "offsets": [ [ 487, 496 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02944929_inc_R1", "type": "Has_value", "arg1_id": "NCT02944929_inc_T3", "arg2_id": "NCT02944929_inc_T4", "normalized": [] }, { "id": "NCT02944929_inc_R2", "type": "Has_multiplier", "arg1_id": "NCT02944929_inc_T6", "arg2_id": "NCT02944929_inc_T7", "normalized": [] }, { "id": "NCT02944929_inc_R3", "type": "Has_temporal", "arg1_id": "NCT02944929_inc_T6", "arg2_id": "NCT02944929_inc_T8", "normalized": [] }, { "id": "NCT02944929_inc_R4", "type": "Subsumes", "arg1_id": "NCT02944929_inc_T6", "arg2_id": "NCT02944929_inc_T9", "normalized": [] }, { "id": "NCT02944929_inc_R5", "type": "Subsumes", "arg1_id": "NCT02944929_inc_T11", "arg2_id": "NCT02944929_inc_T12", "normalized": [] }, { "id": "NCT02944929_inc_R6", "type": "Has_value", "arg1_id": "NCT02944929_inc_T11", "arg2_id": "NCT02944929_inc_T13", "normalized": [] }, { "id": "NCT02944929_inc_R7", "type": "Has_temporal", "arg1_id": "NCT02944929_inc_T15", "arg2_id": "NCT02944929_inc_T16", "normalized": [] }, { "id": "NCT02944929_inc_R8", "type": "Has_index", "arg1_id": "NCT02944929_inc_T16", "arg2_id": "NCT02944929_inc_T17", "normalized": [] } ]

[ { "id": "NCT02946892_exc_text", "type": "exclusion", "text": [ "The use of beta blockers within 2 months of randomization\nPatients actively listed for transplantation at time of entry into the study or anticipated to undergo heart transplantation, interventional catheterization, or corrective cardiac surgery during the 7 months following entry into the study\nSustained or symptomatic ventricular dysrhythmias uncontrolled by drug therapy or the use of an implantable defibrillator, and/or significant cardiac conduction defects, e.g., 2nd degree or 3rd degree AV block, or sick sinus syndrome, unless a functioning pacemaker is in place\nUncorrected obstructive or severe regurgitant valve disease, nondilated cardiomyopathy, or significant systemic ventricular outflow obstruction\nKnown renovascular hypertension or evidence of pulmonary hypertension (pulmonary vascular resistance > 6 Wood units) unresponsive to vasodilator agents such as oxygen, nitroprusside, or nitric oxide\nHistory or current clinical evidence of moderate-to-severe fixed obstructive pulmonary disease or severe reactive airway diseases (e.g., asthma) requiring hospitalization within the past 2 years or patient currently using long-term inhaled bronchodilators\nRenal, hepatic, gastrointestinal, or biliary disorder that could impair absorption, metabolism or excretion of orally administered medication\nConcurrent terminal illness or other severe disease (e.g., active neoplasm) or other significant laboratory value(s) which, in the opinion of the investigator, could preclude participation or survival\nEndocrine disorders such as primary aldosteronism, pheochromocytoma, hyper- or hypothyroidism, insulin-dependent diabetes mellitus\nUnwillingness or inability to cooperate, or for the parents or guardians to give consent, or for the child to give assent, or any condition of sufficient severity to impair cooperation in the study\nPregnancy or possible pregnancy at time of randomization, or female of child bearing potential who are lactating, or sexually active and not taking adequate contraceptive precautions (e.g., intrauterine device or oral contraceptives for 3 months prior to entry into the study)\nUse of an investigational drug within 30 days of randomization, or within 5 half-lives of the investigational drug (the longer period will apply)\nHistory of drug sensitivity or allergic reaction to alpha-blockers or beta-blockers\nUse of any of the following medications within two weeks of randomization: MAO inhibitors, Calcium channel blockers, alpha blockers, beta blockers, disopyramide, flecainide, encainide, moricizine, propafenone, sotalol, or beta adrenergic agonists\nHospital admission for protein losing enteropathy or plastic bronchitis within 3 months of randomization\nActive and/or chronic protein losing enteropathy or plastic bronchitis (on inhaled medication to control the plastic bronchitis).\nHypoalbuminemia defined as serum albumin <2.0g/dL\nRenal dysfunction defined as serum creatinine >2.0mg/dL\nHepatic dysfunction defined as serum AST and/or ALT> 3 times upper limit of normal (approximately 120 IU/L however, will vary depending on age),\nSignificant anemia or polycythemia defined as hemoglobin >18gm/dL or hemoglobin <7gm/dL\nSeverely elevated serum BNP defined as BNP>300pg/ml\n" ], "offsets": [ [ 0, 3226 ] ] } ]

[ { "id": "NCT02946892_exc_T1", "type": "Drug", "text": [ "beta blockers" ], "offsets": [ [ 11, 24 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T2", "type": "Temporal", "text": [ "within 2 months of randomization" ], "offsets": [ [ 25, 57 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T3", "type": "Reference_point", "text": [ "randomization" ], "offsets": [ [ 44, 57 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T4", "type": "Observation", "text": [ "listed for transplantation" ], "offsets": [ [ 76, 102 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T5", "type": "Procedure", "text": [ "transplantation" ], "offsets": [ [ 87, 102 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T6", "type": "Temporal", "text": [ "at time of entry into the study" ], "offsets": [ [ 103, 134 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T7", "type": "Reference_point", "text": [ "entry into the study" ], "offsets": [ [ 114, 134 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T8", "type": "Mood", "text": [ "anticipated to undergo" ], "offsets": [ [ 138, 160 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T9", "type": "Procedure", "text": [ "heart transplantation" ], "offsets": [ [ 161, 182 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T10", "type": "Procedure", "text": [ "interventional catheterization" ], "offsets": [ [ 184, 214 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T11", "type": "Procedure", "text": [ "corrective cardiac surgery" ], "offsets": [ [ 219, 245 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T12", "type": "Temporal", "text": [ "during the 7 months following entry into the study" ], "offsets": [ [ 246, 296 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T13", "type": "Reference_point", "text": [ "entry into the study" ], "offsets": [ [ 276, 296 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T14", "type": "Scope", "text": [ "heart transplantation, interventional catheterization, or corrective cardiac surgery" ], "offsets": [ [ 161, 245 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T15", "type": "Qualifier", "text": [ "symptomatic" ], "offsets": [ [ 310, 321 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T16", "type": "Qualifier", "text": [ "Sustained" ], "offsets": [ [ 297, 306 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T17", "type": "Condition", "text": [ "ventricular dysrhythmias" ], "offsets": [ [ 322, 346 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T18", "type": "Qualifier", "text": [ "uncontrolled by drug therapy" ], "offsets": [ [ 347, 375 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T19", "type": "Procedure", "text": [ "drug therapy" ], "offsets": [ [ 363, 375 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T20", "type": "Drug", "text": [ "drug" ], "offsets": [ [ 363, 367 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T21", "type": "Scope", "text": [ "Sustained or symptomatic" ], "offsets": [ [ 297, 321 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T22", "type": "Device", "text": [ "implantable defibrillator" ], "offsets": [ [ 393, 418 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T23", "type": "Qualifier", "text": [ "controlled by d", "e use of an implantable defibrillator," ], "offsets": [ [ 349, 364 ], [ 381, 419 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T24", "type": "Scope", "text": [ "uncontrolled by drug therapy or the use of an implantable defibrillator" ], "offsets": [ [ 347, 418 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T25", "type": "Qualifier", "text": [ "significant" ], "offsets": [ [ 427, 438 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T26", "type": "Condition", "text": [ "cardiac conduction defects" ], "offsets": [ [ 439, 465 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T27", "type": "Condition", "text": [ "d degree o", " block" ], "offsets": [ [ 475, 485 ], [ 500, 506 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T28", "type": "Condition", "text": [ "3rd degree AV block" ], "offsets": [ [ 487, 506 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T29", "type": "Condition", "text": [ "sick sinus syndrome" ], "offsets": [ [ 511, 530 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T30", "type": "Scope", "text": [ "significant cardiac conduction defects" ], "offsets": [ [ 427, 465 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T31", "type": "Scope", "text": [ "2nd degree or 3rd degree AV block, or sick sinus syndrome" ], "offsets": [ [ 473, 530 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T32", "type": "Negation", "text": [ "unless" ], "offsets": [ [ 532, 538 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T33", "type": "Qualifier", "text": [ "functioning" ], "offsets": [ [ 541, 552 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T34", "type": "Device", "text": [ "pacemaker" ], "offsets": [ [ 553, 562 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T35", "type": "Qualifier", "text": [ "Uncorrected" ], "offsets": [ [ 575, 586 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T36", "type": "Condition", "text": [ "tructive or", "ve disease, n" ], "offsets": [ [ 590, 601 ], [ 624, 637 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T37", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 602, 608 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T38", "type": "Condition", "text": [ "regurgitant valve disease" ], "offsets": [ [ 609, 634 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T39", "type": "Condition", "text": [ "nondilated cardiomyopathy" ], "offsets": [ [ 636, 661 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T40", "type": "Qualifier", "text": [ "significant" ], "offsets": [ [ 666, 677 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T41", "type": "Condition", "text": [ "systemic ventricular outflow obstruction" ], "offsets": [ [ 678, 718 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T42", "type": "Condition", "text": [ "renovascular hypertension" ], "offsets": [ [ 725, 750 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T43", "type": "Condition", "text": [ "pulmonary hypertension" ], "offsets": [ [ 766, 788 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T44", "type": "Mood", "text": [ "evidence of" ], "offsets": [ [ 754, 765 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T45", "type": "Measurement", "text": [ "pulmonary vascular resistance" ], "offsets": [ [ 790, 819 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T46", "type": "Value", "text": [ "> 6 Wood units" ], "offsets": [ [ 820, 834 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T47", "type": "Scope", "text": [ "pulmonary vascular resistance > 6 Wood units" ], "offsets": [ [ 790, 834 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T48", "type": "Scope", "text": [ "evidence of pulmonary hypertension" ], "offsets": [ [ 754, 788 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T49", "type": "Qualifier", "text": [ "unresponsive to vasodilator agents" ], "offsets": [ [ 836, 870 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T50", "type": "Drug", "text": [ "vasodilator agents" ], "offsets": [ [ 852, 870 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T51", "type": "Drug", "text": [ "oxygen" ], "offsets": [ [ 879, 885 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T52", "type": "Drug", "text": [ "nitroprusside" ], "offsets": [ [ 887, 900 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T53", "type": "Drug", "text": [ "nitric oxide" ], "offsets": [ [ 905, 917 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T54", "type": "Scope", "text": [ "oxygen, nitroprusside, or nitric oxide" ], "offsets": [ [ 879, 917 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T55", "type": "Scope", "text": [ "renovascular hypertension or evidence of pulmonary hypertension (pulmonary vascular resistance > 6 Wood units)" ], "offsets": [ [ 725, 835 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T56", "type": "Observation", "text": [ "History" ], "offsets": [ [ 918, 925 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T57", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 929, 936 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T58", "type": "Mood", "text": [ "clinical evidence of" ], "offsets": [ [ 937, 957 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T59", "type": "Qualifier", "text": [ "moderate-to-severe" ], "offsets": [ [ 958, 976 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T60", "type": "Qualifier", "text": [ "fixed" ], "offsets": [ [ 977, 982 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T61", "type": "Condition", "text": [ "obstructive pulmonary disease" ], "offsets": [ [ 983, 1012 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T62", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 1016, 1022 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T63", "type": "Condition", "text": [ "reactive airway diseases" ], "offsets": [ [ 1023, 1047 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T64", "type": "Condition", "text": [ "asthma" ], "offsets": [ [ 1055, 1061 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T65", "type": "Scope", "text": [ "reactive airway diseases (e.g., asthma)" ], "offsets": [ [ 1023, 1062 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T66", "type": "Scope", "text": [ "moderate-to-severe fixed obstructive pulmonary disease or severe reactive airway diseases (e.g., asthma)" ], "offsets": [ [ 958, 1062 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T67", "type": "Scope", "text": [ "History or current" ], "offsets": [ [ 918, 936 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T68", "type": "Procedure", "text": [ "hospitalization" ], "offsets": [ [ 1073, 1088 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T69", "type": "Mood", "text": [ "requiring" ], "offsets": [ [ 1063, 1072 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T70", "type": "Temporal", "text": [ "within the past 2 years" ], "offsets": [ [ 1089, 1112 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T71", "type": "Temporal", "text": [ "currently" ], "offsets": [ [ 1124, 1133 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T72", "type": "Drug", "text": [ "long-term inhaled bronchodilators" ], "offsets": [ [ 1140, 1173 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T73", "type": "Reference_point", "text": [ "the past 2 years" ], "offsets": [ [ 1096, 1112 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T74", "type": "Scope", "text": [ "requiring hospitalization within the past 2 years or patient currently using long-term inhaled bronchodilators" ], "offsets": [ [ 1063, 1173 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T75", "type": "Qualifier", "text": [ "Renal" ], "offsets": [ [ 1174, 1179 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T76", "type": "Qualifier", "text": [ "hepatic" ], "offsets": [ [ 1181, 1188 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T77", "type": "Qualifier", "text": [ "gastrointestinal" ], "offsets": [ [ 1190, 1206 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T78", "type": "Qualifier", "text": [ "biliary" ], "offsets": [ [ 1211, 1218 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T79", "type": "Condition", "text": [ "disorder" ], "offsets": [ [ 1219, 1227 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T80", "type": "Scope", "text": [ "Renal, hepatic, gastrointestinal, or biliary" ], "offsets": [ [ 1174, 1218 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T81", "type": "Condition", "text": [ "impair absorption" ], "offsets": [ [ 1239, 1256 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T82", "type": "Condition", "text": [ " abso", "lism or ex" ], "offsets": [ [ 1245, 1250 ], [ 1264, 1274 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T83", "type": "Condition", "text": [ " abso", "ion of or" ], "offsets": [ [ 1245, 1250 ], [ 1278, 1287 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T84", "type": "Drug", "text": [ "orally administered medication" ], "offsets": [ [ 1285, 1315 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T85", "type": "Scope", "text": [ "impair absorption, metabolism or excretion" ], "offsets": [ [ 1239, 1281 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T86", "type": "Temporal", "text": [ "Concurrent" ], "offsets": [ [ 1316, 1326 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T87", "type": "Condition", "text": [ "terminal illness" ], "offsets": [ [ 1327, 1343 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T88", "type": "Condition", "text": [ "severe disease" ], "offsets": [ [ 1353, 1367 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T89", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 1347, 1352 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T90", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 1375, 1381 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T91", "type": "Condition", "text": [ "neoplasm" ], "offsets": [ [ 1382, 1390 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T92", "type": "Scope", "text": [ "active neoplasm" ], "offsets": [ [ 1375, 1390 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T94", "type": "Procedure", "text": [ "laboratory" ], "offsets": [ [ 1413, 1423 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T95", "type": "Condition", "text": [ "significant laboratory value(s)" ], "offsets": [ [ 1401, 1432 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T96", "type": "Measurement", "text": [ "laboratory" ], "offsets": [ [ 1413, 1423 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T97", "type": "Scope", "text": [ "terminal illness or other severe disease (e.g., active neoplasm) or other significant laboratory value(s)" ], "offsets": [ [ 1327, 1432 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T98", "type": "Condition", "text": [ "Endocrine disorders" ], "offsets": [ [ 1517, 1536 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T99", "type": "Condition", "text": [ "primary aldosteronism" ], "offsets": [ [ 1545, 1566 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T100", "type": "Condition", "text": [ "pheochromocytoma" ], "offsets": [ [ 1568, 1584 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T101", "type": "Condition", "text": [ "hypothyroidism" ], "offsets": [ [ 1596, 1610 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T102", "type": "Condition", "text": [ "r hyp", "sm, insuli" ], "offsets": [ [ 1594, 1599 ], [ 1608, 1618 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T103", "type": "Qualifier", "text": [ "insulin-dependent" ], "offsets": [ [ 1612, 1629 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T104", "type": "Condition", "text": [ "diabetes mellitus" ], "offsets": [ [ 1630, 1647 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T105", "type": "Scope", "text": [ "primary aldosteronism, pheochromocytoma, hyper- or hypothyroidism, insulin-dependent diabetes mellitus" ], "offsets": [ [ 1545, 1647 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T106", "type": "Observation", "text": [ "ness or inabi", "ate, or for" ], "offsets": [ [ 1657, 1670 ], [ 1684, 1695 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T107", "type": "Observation", "text": [ "inability to cooperate" ], "offsets": [ [ 1665, 1687 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T108", "type": "Observation", "text": [ "ness or inabi", "arents or guard", "onsent, or for" ], "offsets": [ [ 1657, 1670 ], [ 1701, 1716 ], [ 1730, 1744 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T109", "type": "Observation", "text": [ " to coop", "arents or guard", "onsent, or for" ], "offsets": [ [ 1674, 1682 ], [ 1701, 1716 ], [ 1730, 1744 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T110", "type": "Observation", "text": [ "ness or inabi", "arents", " to give consent, or fo" ], "offsets": [ [ 1657, 1670 ], [ 1701, 1707 ], [ 1720, 1743 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T111", "type": "Observation", "text": [ " to coop", "arents", " to give consent, or fo" ], "offsets": [ [ 1674, 1682 ], [ 1701, 1707 ], [ 1720, 1743 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T112", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 1846, 1855 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T113", "type": "Mood", "text": [ "possible" ], "offsets": [ [ 1859, 1867 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T114", "type": "Condition", "text": [ "pregnancy" ], "offsets": [ [ 1868, 1877 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T115", "type": "Temporal", "text": [ "at time of randomization" ], "offsets": [ [ 1878, 1902 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T116", "type": "Reference_point", "text": [ "time of randomization" ], "offsets": [ [ 1881, 1902 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T117", "type": "Person", "text": [ "female" ], "offsets": [ [ 1907, 1913 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T118", "type": "Observation", "text": [ "child bearing potential" ], "offsets": [ [ 1917, 1940 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T119", "type": "Observation", "text": [ "lactating" ], "offsets": [ [ 1949, 1958 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T120", "type": "Scope", "text": [ "female of child bearing potential who are lactating" ], "offsets": [ [ 1907, 1958 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T121", "type": "Observation", "text": [ "sexually active" ], "offsets": [ [ 1963, 1978 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T122", "type": "Negation", "text": [ "not" ], "offsets": [ [ 1983, 1986 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T123", "type": "Qualifier", "text": [ "adequate" ], "offsets": [ [ 1994, 2002 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T124", "type": "Observation", "text": [ "contraceptive precautions" ], "offsets": [ [ 2003, 2028 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T125", "type": "Device", "text": [ "intrauterine device" ], "offsets": [ [ 2036, 2055 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T126", "type": "Drug", "text": [ "oral contraceptives" ], "offsets": [ [ 2059, 2078 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T127", "type": "Temporal", "text": [ "for 3 months prior to entry into the study" ], "offsets": [ [ 2079, 2121 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T128", "type": "Reference_point", "text": [ "entry into the study" ], "offsets": [ [ 2101, 2121 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T129", "type": "Scope", "text": [ "intrauterine device or oral contraceptives for 3 months prior to entry into the study" ], "offsets": [ [ 2036, 2121 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T130", "type": "Scope", "text": [ "not taking adequate contraceptive precautions" ], "offsets": [ [ 1983, 2028 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T131", "type": "Scope", "text": [ "sexually active and not taking adequate contraceptive precautions (e.g., intrauterine device or oral contraceptives for 3 months prior to entry into the study)" ], "offsets": [ [ 1963, 2122 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T132", "type": "Drug", "text": [ "investigational drug" ], "offsets": [ [ 2133, 2153 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T133", "type": "Temporal", "text": [ "within 30 days of randomization" ], "offsets": [ [ 2154, 2185 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T134", "type": "Reference_point", "text": [ "randomization" ], "offsets": [ [ 2172, 2185 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T135", "type": "Temporal", "text": [ "within 5 half-lives of the investigational drug" ], "offsets": [ [ 2190, 2237 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T136", "type": "Drug", "text": [ "investigational drug" ], "offsets": [ [ 2217, 2237 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T137", "type": "Scope", "text": [ "within 30 days of randomization, or within 5 half-lives of the investigational drug" ], "offsets": [ [ 2154, 2237 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T138", "type": "Observation", "text": [ "History" ], "offsets": [ [ 2269, 2276 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T139", "type": "Condition", "text": [ "drug sensitivity" ], "offsets": [ [ 2280, 2296 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T140", "type": "Condition", "text": [ "allergic reaction" ], "offsets": [ [ 2300, 2317 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T141", "type": "Drug", "text": [ "alpha-blockers" ], "offsets": [ [ 2321, 2335 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T142", "type": "Drug", "text": [ "beta-blockers" ], "offsets": [ [ 2339, 2352 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T143", "type": "Scope", "text": [ "alpha-blockers or beta-blockers" ], "offsets": [ [ 2321, 2352 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T144", "type": "Scope", "text": [ "drug sensitivity or allergic reaction" ], "offsets": [ [ 2280, 2317 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T146", "type": "Temporal", "text": [ "within two weeks of randomization" ], "offsets": [ [ 2393, 2426 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T145", "type": "Drug", "text": [ "MAO inhibitors" ], "offsets": [ [ 2428, 2442 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T147", "type": "Drug", "text": [ "Calcium channel blockers" ], "offsets": [ [ 2444, 2468 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T148", "type": "Drug", "text": [ "alpha blockers" ], "offsets": [ [ 2470, 2484 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T149", "type": "Drug", "text": [ "beta blockers" ], "offsets": [ [ 2486, 2499 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T150", "type": "Drug", "text": [ "disopyramide" ], "offsets": [ [ 2501, 2513 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T151", "type": "Drug", "text": [ "flecainide" ], "offsets": [ [ 2515, 2525 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T152", "type": "Drug", "text": [ "encainide" ], "offsets": [ [ 2527, 2536 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T153", "type": "Drug", "text": [ "moricizine" ], "offsets": [ [ 2538, 2548 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T154", "type": "Drug", "text": [ "propafenone" ], "offsets": [ [ 2550, 2561 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T155", "type": "Drug", "text": [ "sotalol" ], "offsets": [ [ 2563, 2570 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T156", "type": "Drug", "text": [ "beta adrenergic agonists" ], "offsets": [ [ 2575, 2599 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T157", "type": "Scope", "text": [ "MAO inhibitors, Calcium channel blockers, alpha blockers, beta blockers, disopyramide, flecainide, encainide, moricizine, propafenone, sotalol, or beta adrenergic agonists" ], "offsets": [ [ 2428, 2599 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T158", "type": "Procedure", "text": [ "Hospital admission" ], "offsets": [ [ 2600, 2618 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T159", "type": "Condition", "text": [ "protein losing enteropathy" ], "offsets": [ [ 2623, 2649 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T160", "type": "Condition", "text": [ "plastic bronchitis" ], "offsets": [ [ 2653, 2671 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T161", "type": "Temporal", "text": [ "within 3 months of randomization" ], "offsets": [ [ 2672, 2704 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T162", "type": "Scope", "text": [ "protein losing enteropathy or plastic bronchitis" ], "offsets": [ [ 2623, 2671 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T163", "type": "Reference_point", "text": [ "randomization" ], "offsets": [ [ 2691, 2704 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T164", "type": "Qualifier", "text": [ "Active" ], "offsets": [ [ 2705, 2711 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T165", "type": "Qualifier", "text": [ "chronic" ], "offsets": [ [ 2719, 2726 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T166", "type": "Condition", "text": [ "protein losing enteropathy" ], "offsets": [ [ 2727, 2753 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T167", "type": "Condition", "text": [ "plastic bronchitis" ], "offsets": [ [ 2757, 2775 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T168", "type": "Drug", "text": [ "inhaled medication" ], "offsets": [ [ 2780, 2798 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T169", "type": "Scope", "text": [ "protein losing enteropathy or plastic bronchitis (on inhaled medication to control the plastic bronchitis)" ], "offsets": [ [ 2727, 2833 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T170", "type": "Scope", "text": [ "Active and/or chronic" ], "offsets": [ [ 2705, 2726 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T171", "type": "Condition", "text": [ "Hypoalbuminemia" ], "offsets": [ [ 2835, 2850 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T172", "type": "Measurement", "text": [ "serum albumin" ], "offsets": [ [ 2862, 2875 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T173", "type": "Value", "text": [ "<2.0g/dL" ], "offsets": [ [ 2876, 2884 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T174", "type": "Condition", "text": [ "Renal dysfunction" ], "offsets": [ [ 2885, 2902 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T175", "type": "Measurement", "text": [ "serum creatinine" ], "offsets": [ [ 2914, 2930 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T176", "type": "Value", "text": [ ">2.0mg/dL" ], "offsets": [ [ 2931, 2940 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T177", "type": "Condition", "text": [ "Hepatic dysfunction" ], "offsets": [ [ 2941, 2960 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T178", "type": "Measurement", "text": [ "serum AST" ], "offsets": [ [ 2972, 2981 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T179", "type": "Measurement", "text": [ "LT> 3", " l" ], "offsets": [ [ 2990, 2995 ], [ 3007, 3009 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T180", "type": "Value", "text": [ "> 3 times upper limit of normal" ], "offsets": [ [ 2992, 3023 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T181", "type": "Scope", "text": [ "serum AST and/or ALT" ], "offsets": [ [ 2972, 2992 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T182", "type": "Value", "text": [ "approximately 120 IU/L" ], "offsets": [ [ 3025, 3047 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T184", "type": "Scope", "text": [ "serum AST and/or ALT> 3 times upper limit of normal (approximately 120 IU/L however, will vary depending on age)" ], "offsets": [ [ 2972, 3084 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T185", "type": "Qualifier", "text": [ "Significant" ], "offsets": [ [ 3086, 3097 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T186", "type": "Condition", "text": [ "anemia" ], "offsets": [ [ 3098, 3104 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T187", "type": "Condition", "text": [ "polycythemia" ], "offsets": [ [ 3108, 3120 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T188", "type": "Measurement", "text": [ "hemoglobin" ], "offsets": [ [ 3155, 3165 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T189", "type": "Value", "text": [ ">18gm/dL" ], "offsets": [ [ 3143, 3151 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T190", "type": "Measurement", "text": [ "hemoglobin" ], "offsets": [ [ 3155, 3165 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T191", "type": "Value", "text": [ "<7gm/dL" ], "offsets": [ [ 3166, 3173 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T192", "type": "Scope", "text": [ "hemoglobin >18gm/dL or hemoglobin <7gm/dL" ], "offsets": [ [ 3132, 3173 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T193", "type": "Scope", "text": [ "Significant anemia or polycythemia" ], "offsets": [ [ 3086, 3120 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T194", "type": "Scope", "text": [ "anemia or polycythemia" ], "offsets": [ [ 3098, 3120 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T195", "type": "Value", "text": [ "Severely elevated" ], "offsets": [ [ 3174, 3191 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T196", "type": "Measurement", "text": [ "serum BNP" ], "offsets": [ [ 3192, 3201 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T197", "type": "Measurement", "text": [ "BNP" ], "offsets": [ [ 3213, 3216 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T198", "type": "Value", "text": [ ">300pg/ml" ], "offsets": [ [ 3216, 3225 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T199", "type": "Scope", "text": [ "Severely elevated serum BNP" ], "offsets": [ [ 3174, 3201 ] ], "normalized": [] }, { "id": "NCT02946892_exc_T200", "type": "Scope", "text": [ "BNP>300pg/ml" ], "offsets": [ [ 3213, 3225 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02946892_exc_R1", "type": "Has_index", "arg1_id": "NCT02946892_exc_T2", "arg2_id": "NCT02946892_exc_T3", "normalized": [] }, { "id": "NCT02946892_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02946892_exc_T1", "arg2_id": "NCT02946892_exc_T2", "normalized": [] }, { "id": "NCT02946892_exc_R4", "type": "Has_index", "arg1_id": "NCT02946892_exc_T6", "arg2_id": "NCT02946892_exc_T7", "normalized": [] }, { "id": "NCT02946892_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02946892_exc_T4", "arg2_id": "NCT02946892_exc_T6", "normalized": [] }, { "id": "NCT02946892_exc_R6", "type": "Has_index", "arg1_id": "NCT02946892_exc_T12", "arg2_id": "NCT02946892_exc_T13", "normalized": [] }, { "id": "NCT02946892_exc_R7", "type": "Has_mood", "arg1_id": "NCT02946892_exc_T14", "arg2_id": "NCT02946892_exc_T8", "normalized": [] }, { "id": "NCT02946892_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02946892_exc_T14", "arg2_id": "NCT02946892_exc_T12", "normalized": [] }, { "id": "NCT02946892_exc_R11", "type": "Has_scope", "arg1_id": "NCT02946892_exc_T17", "arg2_id": "NCT02946892_exc_T21", "normalized": [] }, { "id": "NCT02946892_exc_R13", "type": "Has_scope", "arg1_id": "NCT02946892_exc_T17", "arg2_id": "NCT02946892_exc_T24", "normalized": [] }, { "id": "NCT02946892_exc_R14", "type": "Has_qualifier", "arg1_id": "NCT02946892_exc_T26", "arg2_id": "NCT02946892_exc_T25", "normalized": [] }, { "id": "NCT02946892_exc_R15", "type": "Has_qualifier", "arg1_id": "NCT02946892_exc_T34", "arg2_id": "NCT02946892_exc_T33", "normalized": [] }, { "id": "NCT02946892_exc_R16", "type": "Has_negation", "arg1_id": "NCT02946892_exc_T34", "arg2_id": "NCT02946892_exc_T32", "normalized": [] }, { "id": "NCT02946892_exc_R17", "type": "AND", "arg1_id": "NCT02946892_exc_T31", "arg2_id": "NCT02946892_exc_T34", "normalized": [] }, { "id": "NCT02946892_exc_R18", "type": "Has_scope", "arg1_id": "NCT02946892_exc_T30", "arg2_id": "NCT02946892_exc_T31", "normalized": [] }, { "id": "NCT02946892_exc_R19", "type": "Has_qualifier", "arg1_id": "NCT02946892_exc_T36", "arg2_id": "NCT02946892_exc_T35", "normalized": [] }, { "id": "NCT02946892_exc_R20", "type": "Has_qualifier", "arg1_id": "NCT02946892_exc_T38", "arg2_id": "NCT02946892_exc_T37", "normalized": [] }, { "id": "NCT02946892_exc_R21", "type": "Has_qualifier", "arg1_id": "NCT02946892_exc_T41", "arg2_id": "NCT02946892_exc_T40", "normalized": [] }, { "id": "NCT02946892_exc_R22", "type": "Has_mood", "arg1_id": "NCT02946892_exc_T43", "arg2_id": "NCT02946892_exc_T44", "normalized": [] }, { "id": "NCT02946892_exc_R23", "type": "Has_value", "arg1_id": "NCT02946892_exc_T45", "arg2_id": "NCT02946892_exc_T46", "normalized": [] }, { "id": "NCT02946892_exc_R24", "type": "Subsumes", "arg1_id": "NCT02946892_exc_T48", "arg2_id": "NCT02946892_exc_T47", "normalized": [] }, { "id": "NCT02946892_exc_R26", "type": "Subsumes", "arg1_id": "NCT02946892_exc_T50", "arg2_id": "NCT02946892_exc_T54", "normalized": [] }, { "id": "NCT02946892_exc_R27", "type": "Has_qualifier", "arg1_id": "NCT02946892_exc_T55", "arg2_id": "NCT02946892_exc_T49", "normalized": [] }, { "id": "NCT02946892_exc_R28", "type": "Has_qualifier", "arg1_id": "NCT02946892_exc_T61", "arg2_id": "NCT02946892_exc_T60", "normalized": [] }, { "id": "NCT02946892_exc_R29", "type": "Has_qualifier", "arg1_id": "NCT02946892_exc_T61", "arg2_id": "NCT02946892_exc_T59", "normalized": [] }, { "id": "NCT02946892_exc_R30", "type": "Subsumes", "arg1_id": "NCT02946892_exc_T63", "arg2_id": "NCT02946892_exc_T64", "normalized": [] }, { "id": "NCT02946892_exc_R31", "type": "Has_qualifier", "arg1_id": "NCT02946892_exc_T65", "arg2_id": "NCT02946892_exc_T62", "normalized": [] }, { "id": "NCT02946892_exc_R32", "type": "Has_mood", "arg1_id": "NCT02946892_exc_T66", "arg2_id": "NCT02946892_exc_T58", "normalized": [] }, { "id": "NCT02946892_exc_R33", "type": "Has_scope", "arg1_id": "NCT02946892_exc_T66", "arg2_id": "NCT02946892_exc_T67", "normalized": [] }, { "id": "NCT02946892_exc_R34", "type": "Has_mood", "arg1_id": "NCT02946892_exc_T68", "arg2_id": "NCT02946892_exc_T69", "normalized": [] }, { "id": "NCT02946892_exc_R35", "type": "Has_temporal", "arg1_id": "NCT02946892_exc_T72", "arg2_id": "NCT02946892_exc_T71", "normalized": [] }, { "id": "NCT02946892_exc_R36", "type": "Has_temporal", "arg1_id": "NCT02946892_exc_T68", "arg2_id": "NCT02946892_exc_T70", "normalized": [] }, { "id": "NCT02946892_exc_R37", "type": "Has_index", "arg1_id": "NCT02946892_exc_T70", "arg2_id": "NCT02946892_exc_T73", "normalized": [] }, { "id": "NCT02946892_exc_R38", "type": "Has_scope", "arg1_id": "NCT02946892_exc_T66", "arg2_id": "NCT02946892_exc_T74", "normalized": [] }, { "id": "NCT02946892_exc_R39", "type": "Has_scope", "arg1_id": "NCT02946892_exc_T79", "arg2_id": "NCT02946892_exc_T80", "normalized": [] }, { "id": "NCT02946892_exc_R40", "type": "AND", "arg1_id": "NCT02946892_exc_T85", "arg2_id": "NCT02946892_exc_T84", "normalized": [] }, { "id": "NCT02946892_exc_R41", "type": "Has_scope", "arg1_id": "NCT02946892_exc_T79", "arg2_id": "NCT02946892_exc_T85", "normalized": [] }, { "id": "NCT02946892_exc_R42", "type": "Has_qualifier", "arg1_id": "NCT02946892_exc_T88", "arg2_id": "NCT02946892_exc_T89", "normalized": [] }, { "id": "NCT02946892_exc_R43", "type": "Has_qualifier", "arg1_id": "NCT02946892_exc_T91", "arg2_id": "NCT02946892_exc_T90", "normalized": [] }, { "id": "NCT02946892_exc_R44", "type": "Subsumes", "arg1_id": "NCT02946892_exc_T88", "arg2_id": "NCT02946892_exc_T92", "normalized": [] }, { "id": "NCT02946892_exc_R47", "type": "Has_temporal", "arg1_id": "NCT02946892_exc_T97", "arg2_id": "NCT02946892_exc_T86", "normalized": [] }, { "id": "NCT02946892_exc_R48", "type": "Has_qualifier", "arg1_id": "NCT02946892_exc_T104", "arg2_id": "NCT02946892_exc_T103", "normalized": [] }, { "id": "NCT02946892_exc_R49", "type": "Subsumes", "arg1_id": "NCT02946892_exc_T98", "arg2_id": "NCT02946892_exc_T105", "normalized": [] }, { "id": "NCT02946892_exc_R50", "type": "Has_mood", "arg1_id": "NCT02946892_exc_T114", "arg2_id": "NCT02946892_exc_T113", "normalized": [] }, { "id": "NCT02946892_exc_R51", "type": "Has_temporal", "arg1_id": "NCT02946892_exc_T114", "arg2_id": "NCT02946892_exc_T115", "normalized": [] }, { "id": "NCT02946892_exc_R52", "type": "Has_index", "arg1_id": "NCT02946892_exc_T115", "arg2_id": "NCT02946892_exc_T116", "normalized": [] }, { "id": "NCT02946892_exc_R53", "type": "Has_qualifier", "arg1_id": "NCT02946892_exc_T124", "arg2_id": "NCT02946892_exc_T123", "normalized": [] }, { "id": "NCT02946892_exc_R54", "type": "Has_negation", "arg1_id": "NCT02946892_exc_T124", "arg2_id": "NCT02946892_exc_T122", "normalized": [] }, { "id": "NCT02946892_exc_R55", "type": "Has_index", "arg1_id": "NCT02946892_exc_T127", "arg2_id": "NCT02946892_exc_T128", "normalized": [] }, { "id": "NCT02946892_exc_R56", "type": "Has_temporal", "arg1_id": "NCT02946892_exc_T126", "arg2_id": "NCT02946892_exc_T127", "normalized": [] }, { "id": "NCT02946892_exc_R57", "type": "Subsumes", "arg1_id": "NCT02946892_exc_T130", "arg2_id": "NCT02946892_exc_T129", "normalized": [] }, { "id": "NCT02946892_exc_R58", "type": "Has_index", "arg1_id": "NCT02946892_exc_T133", "arg2_id": "NCT02946892_exc_T134", "normalized": [] }, { "id": "NCT02946892_exc_R59", "type": "Has_scope", "arg1_id": "NCT02946892_exc_T132", "arg2_id": "NCT02946892_exc_T137", "normalized": [] }, { "id": "NCT02946892_exc_R61", "type": "Has_scope", "arg1_id": "NCT02946892_exc_T144", "arg2_id": "NCT02946892_exc_T143", "normalized": [] }, { "id": "NCT02946892_exc_R62", "type": "Has_temporal", "arg1_id": "NCT02946892_exc_T144", "arg2_id": "NCT02946892_exc_T138", "normalized": [] }, { "id": "NCT02946892_exc_R63", "type": "Has_temporal", "arg1_id": "NCT02946892_exc_T157", "arg2_id": "NCT02946892_exc_T146", "normalized": [] }, { "id": "NCT02946892_exc_R64", "type": "Has_scope", "arg1_id": "NCT02946892_exc_T158", "arg2_id": "NCT02946892_exc_T162", "normalized": [] }, { "id": "NCT02946892_exc_R65", "type": "Has_temporal", "arg1_id": "NCT02946892_exc_T158", "arg2_id": "NCT02946892_exc_T161", "normalized": [] }, { "id": "NCT02946892_exc_R66", "type": "Has_index", "arg1_id": "NCT02946892_exc_T161", "arg2_id": "NCT02946892_exc_T163", "normalized": [] }, { "id": "NCT02946892_exc_R68", "type": "AND", "arg1_id": "NCT02946892_exc_T167", "arg2_id": "NCT02946892_exc_T168", "normalized": [] }, { "id": "NCT02946892_exc_R67", "type": "Has_scope", "arg1_id": "NCT02946892_exc_T169", "arg2_id": "NCT02946892_exc_T170", "normalized": [] }, { "id": "NCT02946892_exc_R69", "type": "Has_value", "arg1_id": "NCT02946892_exc_T172", "arg2_id": "NCT02946892_exc_T173", "normalized": [] }, { "id": "NCT02946892_exc_R70", "type": "Subsumes", "arg1_id": "NCT02946892_exc_T171", "arg2_id": "NCT02946892_exc_T172", "normalized": [] }, { "id": "NCT02946892_exc_R71", "type": "AND", "arg1_id": "NCT02946892_exc_T174", "arg2_id": "NCT02946892_exc_T175", "normalized": [] }, { "id": "NCT02946892_exc_R72", "type": "Has_value", "arg1_id": "NCT02946892_exc_T175", "arg2_id": "NCT02946892_exc_T176", "normalized": [] }, { "id": "NCT02946892_exc_R73", "type": "Has_value", "arg1_id": "NCT02946892_exc_T181", "arg2_id": "NCT02946892_exc_T180", "normalized": [] }, { "id": "NCT02946892_exc_R74", "type": "Subsumes", "arg1_id": "NCT02946892_exc_T180", "arg2_id": "NCT02946892_exc_T182", "normalized": [] }, { "id": "NCT02946892_exc_R75", "type": "Subsumes", "arg1_id": "NCT02946892_exc_T177", "arg2_id": "NCT02946892_exc_T184", "normalized": [] }, { "id": "NCT02946892_exc_R77", "type": "Has_value", "arg1_id": "NCT02946892_exc_T190", "arg2_id": "NCT02946892_exc_T191", "normalized": [] }, { "id": "NCT02946892_exc_R78", "type": "Has_value", "arg1_id": "NCT02946892_exc_T188", "arg2_id": "NCT02946892_exc_T189", "normalized": [] }, { "id": "NCT02946892_exc_R76", "type": "Subsumes", "arg1_id": "NCT02946892_exc_T193", "arg2_id": "NCT02946892_exc_T192", "normalized": [] }, { "id": "NCT02946892_exc_R79", "type": "Has_qualifier", "arg1_id": "NCT02946892_exc_T194", "arg2_id": "NCT02946892_exc_T185", "normalized": [] }, { "id": "NCT02946892_exc_R80", "type": "Has_value", "arg1_id": "NCT02946892_exc_T196", "arg2_id": "NCT02946892_exc_T195", "normalized": [] }, { "id": "NCT02946892_exc_R81", "type": "Has_value", "arg1_id": "NCT02946892_exc_T197", "arg2_id": "NCT02946892_exc_T198", "normalized": [] }, { "id": "NCT02946892_exc_R82", "type": "Subsumes", "arg1_id": "NCT02946892_exc_T199", "arg2_id": "NCT02946892_exc_T200", "normalized": [] } ]

[ { "id": "NCT02946892_inc_text", "type": "inclusion", "text": [ "Informed consent of parent(s) or legal guardian; informed consent or assent of subject as applicable.\nMale or female children between the ages of 10 and 35 years with congenital heart disease that has been palliated with a Fontan circulation.\nAbility of perform a maximal exercise test as defined by a respiratory exchange ratio (RER) greater than 1.0 at the time of maximal exercise\n" ], "offsets": [ [ 0, 384 ] ] } ]

[ { "id": "NCT02946892_inc_T1", "type": "Observation", "text": [ "Informed consent of parent" ], "offsets": [ [ 0, 26 ] ], "normalized": [] }, { "id": "NCT02946892_inc_T2", "type": "Observation", "text": [ "Informed consent of", "legal guardian" ], "offsets": [ [ 0, 19 ], [ 33, 47 ] ], "normalized": [] }, { "id": "NCT02946892_inc_T3", "type": "Observation", "text": [ "informed consent", "of subject" ], "offsets": [ [ 49, 65 ], [ 76, 86 ] ], "normalized": [] }, { "id": "NCT02946892_inc_T4", "type": "Observation", "text": [ "informed", "assent of subject" ], "offsets": [ [ 49, 57 ], [ 69, 86 ] ], "normalized": [] }, { "id": "NCT02946892_inc_T5", "type": "Person", "text": [ "Male" ], "offsets": [ [ 102, 106 ] ], "normalized": [] }, { "id": "NCT02946892_inc_T6", "type": "Person", "text": [ "female" ], "offsets": [ [ 110, 116 ] ], "normalized": [] }, { "id": "NCT02946892_inc_T7", "type": "Person", "text": [ "children" ], "offsets": [ [ 117, 125 ] ], "normalized": [] }, { "id": "NCT02946892_inc_T8", "type": "Value", "text": [ "etween", "0 and 35 years" ], "offsets": [ [ 127, 133 ], [ 147, 161 ] ], "normalized": [] }, { "id": "NCT02946892_inc_T9", "type": "Person", "text": [ "ages" ], "offsets": [ [ 138, 142 ] ], "normalized": [] }, { "id": "NCT02946892_inc_T10", "type": "Condition", "text": [ "congenital heart disease" ], "offsets": [ [ 167, 191 ] ], "normalized": [] }, { "id": "NCT02946892_inc_T11", "type": "Procedure", "text": [ "Fontan circulation" ], "offsets": [ [ 223, 241 ] ], "normalized": [] }, { "id": "NCT02946892_inc_T12", "type": "Observation", "text": [ "Ability of perform" ], "offsets": [ [ 243, 261 ] ], "normalized": [] }, { "id": "NCT02946892_inc_T13", "type": "Procedure", "text": [ "maximal exercise test" ], "offsets": [ [ 264, 285 ] ], "normalized": [] }, { "id": "NCT02946892_inc_T14", "type": "Measurement", "text": [ "respiratory exchange ratio (RER)" ], "offsets": [ [ 302, 334 ] ], "normalized": [] }, { "id": "NCT02946892_inc_T15", "type": "Value", "text": [ "greater than 1.0" ], "offsets": [ [ 335, 351 ] ], "normalized": [] }, { "id": "NCT02946892_inc_T16", "type": "Qualifier", "text": [ "at the time of maximal exercise" ], "offsets": [ [ 352, 383 ] ], "normalized": [] }, { "id": "NCT02946892_inc_T17", "type": "Scope", "text": [ "Ability of perform a maximal exercise test" ], "offsets": [ [ 243, 285 ] ], "normalized": [] }, { "id": "NCT02946892_inc_T18", "type": "Scope", "text": [ "respiratory exchange ratio (RER) greater than 1.0 at the time of maximal exercise" ], "offsets": [ [ 302, 383 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02946892_inc_R1", "type": "Has_value", "arg1_id": "NCT02946892_inc_T9", "arg2_id": "NCT02946892_inc_T8", "normalized": [] }, { "id": "NCT02946892_inc_R2", "type": "AND", "arg1_id": "NCT02946892_inc_T10", "arg2_id": "NCT02946892_inc_T11", "normalized": [] }, { "id": "NCT02946892_inc_R3", "type": "AND", "arg1_id": "NCT02946892_inc_T12", "arg2_id": "NCT02946892_inc_T13", "normalized": [] }, { "id": "NCT02946892_inc_R4", "type": "Has_value", "arg1_id": "NCT02946892_inc_T14", "arg2_id": "NCT02946892_inc_T15", "normalized": [] }, { "id": "NCT02946892_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT02946892_inc_T14", "arg2_id": "NCT02946892_inc_T16", "normalized": [] }, { "id": "NCT02946892_inc_R6", "type": "Subsumes", "arg1_id": "NCT02946892_inc_T17", "arg2_id": "NCT02946892_inc_T18", "normalized": [] } ]

[ { "id": "NCT02946918_exc_text", "type": "exclusion", "text": [ "AJCC Stage III or greater\nUndifferentiated, Anaplastic or Medullary Thyroid Cancer\nPlanned postoperative TSH goal other than 0.1-0.5 mU/L\nHistory of gastrointestinal malabsorption or gastric bypass surgery\nPregnancy\nUse of medications that alter the absorption or metabolism of levothyroxine\nPrior use of levothyroxine\n" ], "offsets": [ [ 0, 319 ] ] } ]

[ { "id": "NCT02946918_exc_T1", "type": "Measurement", "text": [ "AJCC" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "NCT02946918_exc_T2", "type": "Value", "text": [ "Stage III or greater" ], "offsets": [ [ 5, 25 ] ], "normalized": [] }, { "id": "NCT02946918_exc_T3", "type": "Condition", "text": [ "Medullary Thyroid Cancer" ], "offsets": [ [ 58, 82 ] ], "normalized": [] }, { "id": "NCT02946918_exc_T4", "type": "Condition", "text": [ "naplastic", "hyroid Cancer" ], "offsets": [ [ 45, 54 ], [ 69, 82 ] ], "normalized": [] }, { "id": "NCT02946918_exc_T5", "type": "Condition", "text": [ "ndifferentiated,", "hyroid Cancer" ], "offsets": [ [ 27, 43 ], [ 69, 82 ] ], "normalized": [] }, { "id": "NCT02946918_exc_T6", "type": "Measurement", "text": [ "TSH" ], "offsets": [ [ 105, 108 ] ], "normalized": [] }, { "id": "NCT02946918_exc_T7", "type": "Qualifier", "text": [ "postoperative" ], "offsets": [ [ 91, 104 ] ], "normalized": [] }, { "id": "NCT02946918_exc_T8", "type": "Value", "text": [ "0.1-0.5 mU/L" ], "offsets": [ [ 125, 137 ] ], "normalized": [] }, { "id": "NCT02946918_exc_T9", "type": "Negation", "text": [ "other than" ], "offsets": [ [ 114, 124 ] ], "normalized": [] }, { "id": "NCT02946918_exc_T10", "type": "Condition", "text": [ "gastrointestinal malabsorption" ], "offsets": [ [ 149, 179 ] ], "normalized": [] }, { "id": "NCT02946918_exc_T11", "type": "Procedure", "text": [ "gastric bypass surgery" ], "offsets": [ [ 183, 205 ] ], "normalized": [] }, { "id": "NCT02946918_exc_T13", "type": "Drug", "text": [ "medications" ], "offsets": [ [ 223, 234 ] ], "normalized": [] }, { "id": "NCT02946918_exc_T14", "type": "Observation", "text": [ "metabolism of levothyroxine" ], "offsets": [ [ 264, 291 ] ], "normalized": [] }, { "id": "NCT02946918_exc_T15", "type": "Drug", "text": [ "levothyroxine" ], "offsets": [ [ 278, 291 ] ], "normalized": [] }, { "id": "NCT02946918_exc_T16", "type": "Drug", "text": [ "levothyroxine" ], "offsets": [ [ 305, 318 ] ], "normalized": [] }, { "id": "NCT02946918_exc_T17", "type": "Temporal", "text": [ "Prior" ], "offsets": [ [ 292, 297 ] ], "normalized": [] }, { "id": "NCT02946918_exc_T18", "type": "Observation", "text": [ "ption or m", "vothyroxine\nPrio" ], "offsets": [ [ 255, 265 ], [ 280, 296 ] ], "normalized": [] }, { "id": "NCT02946918_exc_T19", "type": "Scope", "text": [ "absorption or metabolism of levothyroxine" ], "offsets": [ [ 250, 291 ] ], "normalized": [] }, { "id": "NCT02946918_exc_T20", "type": "Negation", "text": [ "alter" ], "offsets": [ [ 240, 245 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02946918_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02946918_exc_T6", "arg2_id": "NCT02946918_exc_T7", "normalized": [] }, { "id": "NCT02946918_exc_R2", "type": "Has_negation", "arg1_id": "NCT02946918_exc_T8", "arg2_id": "NCT02946918_exc_T9", "normalized": [] }, { "id": "NCT02946918_exc_R3", "type": "Has_value", "arg1_id": "NCT02946918_exc_T6", "arg2_id": "NCT02946918_exc_T8", "normalized": [] }, { "id": "NCT02946918_exc_R4", "type": "Has_temporal", "arg1_id": "NCT02946918_exc_T16", "arg2_id": "NCT02946918_exc_T17", "normalized": [] }, { "id": "NCT02946918_exc_R7", "type": "Has_negation", "arg1_id": "NCT02946918_exc_T19", "arg2_id": "NCT02946918_exc_T20", "normalized": [] }, { "id": "NCT02946918_exc_R8", "type": "Has_scope", "arg1_id": "NCT02946918_exc_T13", "arg2_id": "NCT02946918_exc_T19", "normalized": [] } ]

[ { "id": "NCT02946918_inc_text", "type": "inclusion", "text": [ "Age > 18 years\nPresumed AJCC (American Joint Committee on Cancer) tumor Stage I or II\nPlanned total or near-total thyroidectomy\nPlanned goal TSH suppression 0.1-0.5 mU/L for at least 18 weeks postoperatively\nNormal serum TSH within 12 months preceding surgery\n" ], "offsets": [ [ 0, 260 ] ] } ]

[ { "id": "NCT02946918_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02946918_inc_T2", "type": "Value", "text": [ "> 18 years" ], "offsets": [ [ 4, 14 ] ], "normalized": [] }, { "id": "NCT02946918_inc_T3", "type": "Measurement", "text": [ "JCC", "umor Stage I" ], "offsets": [ [ 25, 28 ], [ 67, 79 ] ], "normalized": [] }, { "id": "NCT02946918_inc_T4", "type": "Measurement", "text": [ "American Joint Committee on Cancer" ], "offsets": [ [ 30, 64 ] ], "normalized": [] }, { "id": "NCT02946918_inc_T5", "type": "Value", "text": [ "I" ], "offsets": [ [ 78, 79 ] ], "normalized": [] }, { "id": "NCT02946918_inc_T6", "type": "Value", "text": [ "II" ], "offsets": [ [ 83, 85 ] ], "normalized": [] }, { "id": "NCT02946918_inc_T7", "type": "Scope", "text": [ "I or II" ], "offsets": [ [ 78, 85 ] ], "normalized": [] }, { "id": "NCT02946918_inc_T8", "type": "Procedure", "text": [ "thyroidectomy" ], "offsets": [ [ 114, 127 ] ], "normalized": [] }, { "id": "NCT02946918_inc_T9", "type": "Qualifier", "text": [ "total" ], "offsets": [ [ 94, 99 ] ], "normalized": [] }, { "id": "NCT02946918_inc_T10", "type": "Qualifier", "text": [ "near-total" ], "offsets": [ [ 103, 113 ] ], "normalized": [] }, { "id": "NCT02946918_inc_T11", "type": "Scope", "text": [ "total or near-total" ], "offsets": [ [ 94, 113 ] ], "normalized": [] }, { "id": "NCT02946918_inc_T12", "type": "Temporal", "text": [ "at least 18 weeks postoperatively" ], "offsets": [ [ 174, 207 ] ], "normalized": [] }, { "id": "NCT02946918_inc_T13", "type": "Reference_point", "text": [ "postoperatively" ], "offsets": [ [ 192, 207 ] ], "normalized": [] }, { "id": "NCT02946918_inc_T14", "type": "Condition", "text": [ "TSH suppression" ], "offsets": [ [ 141, 156 ] ], "normalized": [] }, { "id": "NCT02946918_inc_T15", "type": "Value", "text": [ "0.1-0.5 mU/L" ], "offsets": [ [ 157, 169 ] ], "normalized": [] }, { "id": "NCT02946918_inc_T16", "type": "Measurement", "text": [ "serum TSH" ], "offsets": [ [ 215, 224 ] ], "normalized": [] }, { "id": "NCT02946918_inc_T17", "type": "Value", "text": [ "Normal" ], "offsets": [ [ 208, 214 ] ], "normalized": [] }, { "id": "NCT02946918_inc_T18", "type": "Temporal", "text": [ "within 12 months preceding surgery" ], "offsets": [ [ 225, 259 ] ], "normalized": [] }, { "id": "NCT02946918_inc_T19", "type": "Reference_point", "text": [ "surgery" ], "offsets": [ [ 252, 259 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02946918_inc_R1", "type": "Subsumes", "arg1_id": "NCT02946918_inc_T3", "arg2_id": "NCT02946918_inc_T4", "normalized": [] }, { "id": "NCT02946918_inc_R2", "type": "Has_scope", "arg1_id": "NCT02946918_inc_T3", "arg2_id": "NCT02946918_inc_T7", "normalized": [] }, { "id": "NCT02946918_inc_R3", "type": "Has_scope", "arg1_id": "NCT02946918_inc_T8", "arg2_id": "NCT02946918_inc_T11", "normalized": [] }, { "id": "NCT02946918_inc_R4", "type": "Has_index", "arg1_id": "NCT02946918_inc_T12", "arg2_id": "NCT02946918_inc_T13", "normalized": [] }, { "id": "NCT02946918_inc_R5", "type": "Has_value", "arg1_id": "NCT02946918_inc_T14", "arg2_id": "NCT02946918_inc_T15", "normalized": [] }, { "id": "NCT02946918_inc_R6", "type": "Has_temporal", "arg1_id": "NCT02946918_inc_T14", "arg2_id": "NCT02946918_inc_T12", "normalized": [] }, { "id": "NCT02946918_inc_R7", "type": "Has_index", "arg1_id": "NCT02946918_inc_T18", "arg2_id": "NCT02946918_inc_T19", "normalized": [] }, { "id": "NCT02946918_inc_R8", "type": "Has_value", "arg1_id": "NCT02946918_inc_T16", "arg2_id": "NCT02946918_inc_T17", "normalized": [] }, { "id": "NCT02946918_inc_R9", "type": "Has_temporal", "arg1_id": "NCT02946918_inc_T16", "arg2_id": "NCT02946918_inc_T18", "normalized": [] } ]

[ { "id": "NCT02950558_exc_text", "type": "exclusion", "text": [ "Unable to give informed consent in English\nUnable to complete surveys in English\nUnable to understand instructions for using pump in English\nUnavailable for followup\nPolytrauma; undergoing other surgeries or having other orthopedic injuries related to the precipitating cause of the ankle fracture\nInfection\nPeripheral vascular disease\nDiabetes\nCurrently undergoing chemotherapy\nPregnancy\nCurrently lactating\nHeart disease or heart rhythm disorder or taking anti-arrhythmic drugs\nSevere renal impairment (Class 3 or worse kidney disease)\nLiver disease (cirrhosis or liver failure)\nPrior allergic reaction to any type of local anesthetic\nTaking therapeutic doses of anti-coagulants or anti-platelet therapy (prophylactic doses started because of hospital admission are not an exclusion)\nCurrently taking antidepressants or other psychiatric medications\nSingle shot local nerve block prior to surgery was ineffective\nSelected for neuraxial anesthesia rather than general anesthesia for the open reduction surgery\nAlready receiving chronic analgesic therapy for a separate chronic pain condition\n" ], "offsets": [ [ 0, 1093 ] ] } ]

[ { "id": "NCT02950558_exc_T5", "type": "Condition", "text": [ "Polytrauma" ], "offsets": [ [ 166, 176 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T6", "type": "Procedure", "text": [ "other surgeries" ], "offsets": [ [ 189, 204 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T7", "type": "Condition", "text": [ "other orthopedic injuries" ], "offsets": [ [ 215, 240 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T8", "type": "Condition", "text": [ "ankle fracture" ], "offsets": [ [ 283, 297 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T9", "type": "Condition", "text": [ "Infection" ], "offsets": [ [ 298, 307 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T10", "type": "Condition", "text": [ "Peripheral vascular disease" ], "offsets": [ [ 308, 335 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T11", "type": "Condition", "text": [ "Diabetes" ], "offsets": [ [ 336, 344 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T12", "type": "Procedure", "text": [ "chemotherapy" ], "offsets": [ [ 366, 378 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T13", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 379, 388 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T15", "type": "Condition", "text": [ "Heart disease" ], "offsets": [ [ 409, 422 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T16", "type": "Condition", "text": [ "heart rhythm disorder" ], "offsets": [ [ 426, 447 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T17", "type": "Drug", "text": [ "anti-arrhythmic drugs" ], "offsets": [ [ 458, 479 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T18", "type": "Condition", "text": [ "Severe renal impairment" ], "offsets": [ [ 480, 503 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T20", "type": "Condition", "text": [ "Liver disease" ], "offsets": [ [ 538, 551 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T21", "type": "Condition", "text": [ "liver failure" ], "offsets": [ [ 566, 579 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T22", "type": "Condition", "text": [ "cirrhosis" ], "offsets": [ [ 553, 562 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T23", "type": "Scope", "text": [ "cirrhosis or liver failure" ], "offsets": [ [ 553, 579 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T24", "type": "Condition", "text": [ "allergic reaction" ], "offsets": [ [ 587, 604 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T25", "type": "Drug", "text": [ "local anesthetic" ], "offsets": [ [ 620, 636 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T26", "type": "Drug", "text": [ "anti-coagulants" ], "offsets": [ [ 665, 680 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T27", "type": "Drug", "text": [ "anti-platelet therapy" ], "offsets": [ [ 684, 705 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T28", "type": "Qualifier", "text": [ "therapeutic" ], "offsets": [ [ 644, 655 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T29", "type": "Scope", "text": [ "anti-coagulants or anti-platelet therapy" ], "offsets": [ [ 665, 705 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T30", "type": "Qualifier", "text": [ "prophylactic" ], "offsets": [ [ 707, 719 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T31", "type": "Negation", "text": [ "not" ], "offsets": [ [ 768, 771 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T32", "type": "Drug", "text": [ "antidepressants" ], "offsets": [ [ 803, 818 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T33", "type": "Drug", "text": [ "psychiatric medications" ], "offsets": [ [ 828, 851 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T34", "type": "Multiplier", "text": [ "Single shot" ], "offsets": [ [ 852, 863 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T35", "type": "Procedure", "text": [ "local nerve block" ], "offsets": [ [ 864, 881 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T36", "type": "Temporal", "text": [ "prior to surgery" ], "offsets": [ [ 882, 898 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T37", "type": "Reference_point", "text": [ "surgery" ], "offsets": [ [ 891, 898 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T38", "type": "Procedure", "text": [ "neuraxial anesthesia" ], "offsets": [ [ 928, 948 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T39", "type": "Procedure", "text": [ "general anesthesia" ], "offsets": [ [ 961, 979 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T40", "type": "Negation", "text": [ "rather than" ], "offsets": [ [ 949, 960 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T41", "type": "Procedure", "text": [ "open reduction surgery" ], "offsets": [ [ 988, 1010 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T42", "type": "Scope", "text": [ "neuraxial anesthesia rather than general anesthesia" ], "offsets": [ [ 928, 979 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T43", "type": "Procedure", "text": [ "analgesic therapy" ], "offsets": [ [ 1037, 1054 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T44", "type": "Qualifier", "text": [ "chronic" ], "offsets": [ [ 1029, 1036 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T45", "type": "Condition", "text": [ "chronic pain" ], "offsets": [ [ 1070, 1082 ] ], "normalized": [] }, { "id": "NCT02950558_exc_T46", "type": "Qualifier", "text": [ "separate" ], "offsets": [ [ 1061, 1069 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02950558_exc_R1", "type": "AND", "arg1_id": "NCT02950558_exc_T7", "arg2_id": "NCT02950558_exc_T8", "normalized": [] }, { "id": "NCT02950558_exc_R2", "type": "Subsumes", "arg1_id": "NCT02950558_exc_T20", "arg2_id": "NCT02950558_exc_T23", "normalized": [] }, { "id": "NCT02950558_exc_R3", "type": "AND", "arg1_id": "NCT02950558_exc_T24", "arg2_id": "NCT02950558_exc_T25", "normalized": [] }, { "id": "NCT02950558_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT02950558_exc_T29", "arg2_id": "NCT02950558_exc_T28", "normalized": [] }, { "id": "NCT02950558_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02950558_exc_T29", "arg2_id": "NCT02950558_exc_T30", "normalized": [] }, { "id": "NCT02950558_exc_R6", "type": "Has_multiplier", "arg1_id": "NCT02950558_exc_T35", "arg2_id": "NCT02950558_exc_T34", "normalized": [] }, { "id": "NCT02950558_exc_R7", "type": "Has_index", "arg1_id": "NCT02950558_exc_T36", "arg2_id": "NCT02950558_exc_T37", "normalized": [] }, { "id": "NCT02950558_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02950558_exc_T35", "arg2_id": "NCT02950558_exc_T36", "normalized": [] }, { "id": "NCT02950558_exc_R9", "type": "AND", "arg1_id": "NCT02950558_exc_T42", "arg2_id": "NCT02950558_exc_T41", "normalized": [] }, { "id": "NCT02950558_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT02950558_exc_T43", "arg2_id": "NCT02950558_exc_T44", "normalized": [] }, { "id": "NCT02950558_exc_R11", "type": "Has_qualifier", "arg1_id": "NCT02950558_exc_T45", "arg2_id": "NCT02950558_exc_T46", "normalized": [] }, { "id": "NCT02950558_exc_R12", "type": "AND", "arg1_id": "NCT02950558_exc_T43", "arg2_id": "NCT02950558_exc_T45", "normalized": [] } ]

[ { "id": "NCT02950558_inc_text", "type": "inclusion", "text": [ "Referred for surgery for open reduction and internal fixation for ankle fracture\n" ], "offsets": [ [ 0, 81 ] ] } ]

[ { "id": "NCT02950558_inc_T1", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 13, 20 ] ], "normalized": [] }, { "id": "NCT02950558_inc_T2", "type": "Procedure", "text": [ "open reduction and internal fixation" ], "offsets": [ [ 25, 61 ] ], "normalized": [] }, { "id": "NCT02950558_inc_T3", "type": "Condition", "text": [ "ankle fracture" ], "offsets": [ [ 66, 80 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02950558_inc_R1", "type": "AND", "arg1_id": "NCT02950558_inc_T2", "arg2_id": "NCT02950558_inc_T3", "normalized": [] }, { "id": "NCT02950558_inc_R2", "type": "AND", "arg1_id": "NCT02950558_inc_T1", "arg2_id": "NCT02950558_inc_T2", "normalized": [] } ]

[ { "id": "NCT02951520_exc_text", "type": "exclusion", "text": [ "BMI > 30 kg.m-2,\nASA physical state >II\nAllergy to the used local anesthetics\nInfection at the injection site\nage <18y\n" ], "offsets": [ [ 0, 119 ] ] } ]

[ { "id": "NCT02951520_exc_T1", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02951520_exc_T2", "type": "Value", "text": [ "> 30 kg.m-2" ], "offsets": [ [ 4, 15 ] ], "normalized": [] }, { "id": "NCT02951520_exc_T3", "type": "Measurement", "text": [ "ASA physical state" ], "offsets": [ [ 17, 35 ] ], "normalized": [] }, { "id": "NCT02951520_exc_T4", "type": "Value", "text": [ ">II" ], "offsets": [ [ 36, 39 ] ], "normalized": [] }, { "id": "NCT02951520_exc_T5", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 40, 47 ] ], "normalized": [] }, { "id": "NCT02951520_exc_T6", "type": "Drug", "text": [ "local anesthetics" ], "offsets": [ [ 60, 77 ] ], "normalized": [] }, { "id": "NCT02951520_exc_T7", "type": "Condition", "text": [ "Infection" ], "offsets": [ [ 78, 87 ] ], "normalized": [] }, { "id": "NCT02951520_exc_T8", "type": "Qualifier", "text": [ "injection site" ], "offsets": [ [ 95, 109 ] ], "normalized": [] }, { "id": "NCT02951520_exc_T9", "type": "Person", "text": [ "age" ], "offsets": [ [ 110, 113 ] ], "normalized": [] }, { "id": "NCT02951520_exc_T10", "type": "Value", "text": [ "<18y" ], "offsets": [ [ 114, 118 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02951520_exc_R1", "type": "Has_value", "arg1_id": "NCT02951520_exc_T1", "arg2_id": "NCT02951520_exc_T2", "normalized": [] }, { "id": "NCT02951520_exc_R2", "type": "Has_value", "arg1_id": "NCT02951520_exc_T3", "arg2_id": "NCT02951520_exc_T4", "normalized": [] }, { "id": "NCT02951520_exc_R3", "type": "AND", "arg1_id": "NCT02951520_exc_T5", "arg2_id": "NCT02951520_exc_T6", "normalized": [] }, { "id": "NCT02951520_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT02951520_exc_T7", "arg2_id": "NCT02951520_exc_T8", "normalized": [] }, { "id": "NCT02951520_exc_R5", "type": "Has_value", "arg1_id": "NCT02951520_exc_T9", "arg2_id": "NCT02951520_exc_T10", "normalized": [] } ]

[ { "id": "NCT02951520_inc_text", "type": "inclusion", "text": [ "Adult patients scheduled for arthroscopic knee ligament reconstruction\n" ], "offsets": [ [ 0, 71 ] ] } ]

[ { "id": "NCT02951520_inc_T1", "type": "Person", "text": [ "Adult" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT02951520_inc_T2", "type": "Mood", "text": [ "scheduled" ], "offsets": [ [ 15, 24 ] ], "normalized": [] }, { "id": "NCT02951520_inc_T3", "type": "Procedure", "text": [ "arthroscopic knee ligament reconstruction" ], "offsets": [ [ 29, 70 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02951520_inc_R1", "type": "Has_mood", "arg1_id": "NCT02951520_inc_T3", "arg2_id": "NCT02951520_inc_T2", "normalized": [] } ]

[ { "id": "NCT02951754_exc_text", "type": "exclusion", "text": [ "Contraindication for IR-MPH use\nCurrent stimulant treatment\nEvidence of a clinically significant neurological disease that might affect cognition (e.g., delirium, dementia, epilepsy, head trauma, and multiple sclerosis)\nCurrent or past history of psychosis\nEstimated intelligence quotient score lower than 70\n" ], "offsets": [ [ 0, 309 ] ] } ]

[ { "id": "NCT02951754_exc_T1", "type": "Condition", "text": [ "Contraindication" ], "offsets": [ [ 0, 16 ] ], "normalized": [] }, { "id": "NCT02951754_exc_T2", "type": "Drug", "text": [ "IR-MPH" ], "offsets": [ [ 21, 27 ] ], "normalized": [] }, { "id": "NCT02951754_exc_T3", "type": "Temporal", "text": [ "Current" ], "offsets": [ [ 32, 39 ] ], "normalized": [] }, { "id": "NCT02951754_exc_T4", "type": "Procedure", "text": [ "stimulant treatment" ], "offsets": [ [ 40, 59 ] ], "normalized": [] }, { "id": "NCT02951754_exc_T5", "type": "Mood", "text": [ "Evidence" ], "offsets": [ [ 60, 68 ] ], "normalized": [] }, { "id": "NCT02951754_exc_T6", "type": "Qualifier", "text": [ "clinically significant" ], "offsets": [ [ 74, 96 ] ], "normalized": [] }, { "id": "NCT02951754_exc_T7", "type": "Condition", "text": [ "neurological disease" ], "offsets": [ [ 97, 117 ] ], "normalized": [] }, { "id": "NCT02951754_exc_T8", "type": "Qualifier", "text": [ "might affect cognition" ], "offsets": [ [ 123, 145 ] ], "normalized": [] }, { "id": "NCT02951754_exc_T9", "type": "Condition", "text": [ "delirium" ], "offsets": [ [ 153, 161 ] ], "normalized": [] }, { "id": "NCT02951754_exc_T10", "type": "Condition", "text": [ "dementia" ], "offsets": [ [ 163, 171 ] ], "normalized": [] }, { "id": "NCT02951754_exc_T11", "type": "Condition", "text": [ "epilepsy" ], "offsets": [ [ 173, 181 ] ], "normalized": [] }, { "id": "NCT02951754_exc_T12", "type": "Condition", "text": [ "head trauma" ], "offsets": [ [ 183, 194 ] ], "normalized": [] }, { "id": "NCT02951754_exc_T13", "type": "Condition", "text": [ "multiple sclerosis" ], "offsets": [ [ 200, 218 ] ], "normalized": [] }, { "id": "NCT02951754_exc_T14", "type": "Scope", "text": [ "delirium, dementia, epilepsy, head trauma, and multiple sclerosis" ], "offsets": [ [ 153, 218 ] ], "normalized": [] }, { "id": "NCT02951754_exc_T15", "type": "Scope", "text": [ "clinically significant neurological disease that might affect cognition" ], "offsets": [ [ 74, 145 ] ], "normalized": [] }, { "id": "NCT02951754_exc_T16", "type": "Temporal", "text": [ "Current" ], "offsets": [ [ 220, 227 ] ], "normalized": [] }, { "id": "NCT02951754_exc_T17", "type": "Temporal", "text": [ "past" ], "offsets": [ [ 231, 235 ] ], "normalized": [] }, { "id": "NCT02951754_exc_T18", "type": "Observation", "text": [ "history" ], "offsets": [ [ 236, 243 ] ], "normalized": [] }, { "id": "NCT02951754_exc_T19", "type": "Condition", "text": [ "psychosis" ], "offsets": [ [ 247, 256 ] ], "normalized": [] }, { "id": "NCT02951754_exc_T20", "type": "Scope", "text": [ "Current or past" ], "offsets": [ [ 220, 235 ] ], "normalized": [] }, { "id": "NCT02951754_exc_T21", "type": "Measurement", "text": [ "Estimated intelligence quotient score" ], "offsets": [ [ 257, 294 ] ], "normalized": [] }, { "id": "NCT02951754_exc_T22", "type": "Value", "text": [ "lower than 70" ], "offsets": [ [ 295, 308 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02951754_exc_R1", "type": "AND", "arg1_id": "NCT02951754_exc_T1", "arg2_id": "NCT02951754_exc_T2", "normalized": [] }, { "id": "NCT02951754_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02951754_exc_T4", "arg2_id": "NCT02951754_exc_T3", "normalized": [] }, { "id": "NCT02951754_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02951754_exc_T7", "arg2_id": "NCT02951754_exc_T8", "normalized": [] }, { "id": "NCT02951754_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT02951754_exc_T7", "arg2_id": "NCT02951754_exc_T6", "normalized": [] }, { "id": "NCT02951754_exc_R5", "type": "Has_scope", "arg1_id": "NCT02951754_exc_T15", "arg2_id": "NCT02951754_exc_T14", "normalized": [] }, { "id": "NCT02951754_exc_R6", "type": "Has_mood", "arg1_id": "NCT02951754_exc_T15", "arg2_id": "NCT02951754_exc_T5", "normalized": [] }, { "id": "NCT02951754_exc_R7", "type": "Has_temporal", "arg1_id": "NCT02951754_exc_T19", "arg2_id": "NCT02951754_exc_T18", "normalized": [] }, { "id": "NCT02951754_exc_R8", "type": "Has_scope", "arg1_id": "NCT02951754_exc_T19", "arg2_id": "NCT02951754_exc_T20", "normalized": [] }, { "id": "NCT02951754_exc_R9", "type": "Has_value", "arg1_id": "NCT02951754_exc_T21", "arg2_id": "NCT02951754_exc_T22", "normalized": [] } ]

[ { "id": "NCT02951754_inc_text", "type": "inclusion", "text": [ "White Brazilian of European descent\nFulfillment of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, (DSM-IV) diagnostic criteria for ADHD\nEligibility to immediate-release MPH (IR-MPH) treatment\n" ], "offsets": [ [ 0, 220 ] ] } ]

[ { "id": "NCT02951754_inc_T1", "type": "Person", "text": [ "White" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT02951754_inc_T2", "type": "Person", "text": [ "Brazilian" ], "offsets": [ [ 6, 15 ] ], "normalized": [] }, { "id": "NCT02951754_inc_T3", "type": "Person", "text": [ "European descent" ], "offsets": [ [ 19, 35 ] ], "normalized": [] }, { "id": "NCT02951754_inc_T4", "type": "Qualifier", "text": [ "Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, (DSM-IV) diagnostic criteria" ], "offsets": [ [ 55, 154 ] ], "normalized": [] }, { "id": "NCT02951754_inc_T5", "type": "Condition", "text": [ "ADHD" ], "offsets": [ [ 159, 163 ] ], "normalized": [] }, { "id": "NCT02951754_inc_T6", "type": "Mood", "text": [ "Eligibility" ], "offsets": [ [ 164, 175 ] ], "normalized": [] }, { "id": "NCT02951754_inc_T7", "type": "Drug", "text": [ "immediate-release MPH (IR-MPH)" ], "offsets": [ [ 179, 209 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02951754_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT02951754_inc_T5", "arg2_id": "NCT02951754_inc_T4", "normalized": [] }, { "id": "NCT02951754_inc_R2", "type": "Has_mood", "arg1_id": "NCT02951754_inc_T7", "arg2_id": "NCT02951754_inc_T6", "normalized": [] } ]

[ { "id": "NCT02951832_exc_text", "type": "exclusion", "text": [ "Having experienced severe allergies, trauma history and/or operation history within 3 months; \nWith a history of mental illness and/or family history of mental illness; \nLimb disabled; \nTaking medicine within one month; \nSuffering major events or having mood swings. \n \n" ], "offsets": [ [ 0, 279 ] ] } ]

[ { "id": "NCT02951832_exc_T1", "type": "Condition", "text": [ "severe allergies" ], "offsets": [ [ 19, 35 ] ], "normalized": [] }, { "id": "NCT02951832_exc_T2", "type": "Condition", "text": [ "trauma" ], "offsets": [ [ 37, 43 ] ], "normalized": [] }, { "id": "NCT02951832_exc_T3", "type": "Procedure", "text": [ "operation" ], "offsets": [ [ 59, 68 ] ], "normalized": [] }, { "id": "NCT02951832_exc_T4", "type": "Temporal", "text": [ "within 3 months" ], "offsets": [ [ 77, 92 ] ], "normalized": [] }, { "id": "NCT02951832_exc_T5", "type": "Condition", "text": [ "mental illness" ], "offsets": [ [ 113, 127 ] ], "normalized": [] }, { "id": "NCT02951832_exc_T6", "type": "Observation", "text": [ "family history" ], "offsets": [ [ 135, 149 ] ], "normalized": [] }, { "id": "NCT02951832_exc_T7", "type": "Condition", "text": [ "mental illness" ], "offsets": [ [ 153, 167 ] ], "normalized": [] }, { "id": "NCT02951832_exc_T8", "type": "Observation", "text": [ "history" ], "offsets": [ [ 102, 109 ] ], "normalized": [] }, { "id": "NCT02951832_exc_T9", "type": "Condition", "text": [ "Limb disabled" ], "offsets": [ [ 170, 183 ] ], "normalized": [] }, { "id": "NCT02951832_exc_T10", "type": "Drug", "text": [ "medicine" ], "offsets": [ [ 193, 201 ] ], "normalized": [] }, { "id": "NCT02951832_exc_T11", "type": "Temporal", "text": [ "within one month" ], "offsets": [ [ 202, 218 ] ], "normalized": [] }, { "id": "NCT02951832_exc_T13", "type": "Condition", "text": [ "major events" ], "offsets": [ [ 231, 243 ] ], "normalized": [] }, { "id": "NCT02951832_exc_T16", "type": "Condition", "text": [ "mood swings" ], "offsets": [ [ 254, 265 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02951832_exc_R1", "type": "Has_temporal", "arg1_id": "NCT02951832_exc_T3", "arg2_id": "NCT02951832_exc_T4", "normalized": [] }, { "id": "NCT02951832_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02951832_exc_T2", "arg2_id": "NCT02951832_exc_T4", "normalized": [] }, { "id": "NCT02951832_exc_R3", "type": "Has_temporal", "arg1_id": "NCT02951832_exc_T1", "arg2_id": "NCT02951832_exc_T4", "normalized": [] }, { "id": "NCT02951832_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02951832_exc_T5", "arg2_id": "NCT02951832_exc_T8", "normalized": [] }, { "id": "NCT02951832_exc_R6", "type": "Has_temporal", "arg1_id": "NCT02951832_exc_T10", "arg2_id": "NCT02951832_exc_T11", "normalized": [] } ]

[ { "id": "NCT02951832_inc_text", "type": "inclusion", "text": [ "Women aged 20-49; \nHaving a regular menstrual cycle of which the menstrual period is between day 3-7, and the period between day 25-35; \nExcluding internal and surgical disease (after having variety of physical examination such as electrocardiogram/hepatic and renal function/blood routine and urine routine). \n" ], "offsets": [ [ 0, 311 ] ] } ]

[ { "id": "NCT02951832_inc_T1", "type": "Person", "text": [ "Women" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT02951832_inc_T2", "type": "Person", "text": [ "aged" ], "offsets": [ [ 6, 10 ] ], "normalized": [] }, { "id": "NCT02951832_inc_T3", "type": "Value", "text": [ "20-49" ], "offsets": [ [ 11, 16 ] ], "normalized": [] }, { "id": "NCT02951832_inc_T4", "type": "Condition", "text": [ "regular menstrual cycle" ], "offsets": [ [ 28, 51 ] ], "normalized": [] }, { "id": "NCT02951832_inc_T5", "type": "Measurement", "text": [ "menstrual period" ], "offsets": [ [ 65, 81 ] ], "normalized": [] }, { "id": "NCT02951832_inc_T6", "type": "Value", "text": [ "between day 3-7" ], "offsets": [ [ 85, 100 ] ], "normalized": [] }, { "id": "NCT02951832_inc_T8", "type": "Value", "text": [ "between day 25-35" ], "offsets": [ [ 117, 134 ] ], "normalized": [] }, { "id": "NCT02951832_inc_T9", "type": "Scope", "text": [ "between day 3-7, and the period between day 25-35" ], "offsets": [ [ 85, 134 ] ], "normalized": [] }, { "id": "NCT02951832_inc_T10", "type": "Condition", "text": [ "internal", "disease" ], "offsets": [ [ 147, 155 ], [ 169, 176 ] ], "normalized": [] }, { "id": "NCT02951832_inc_T11", "type": "Condition", "text": [ "surgical disease" ], "offsets": [ [ 160, 176 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02951832_inc_R1", "type": "Has_value", "arg1_id": "NCT02951832_inc_T2", "arg2_id": "NCT02951832_inc_T3", "normalized": [] }, { "id": "NCT02951832_inc_R2", "type": "Has_scope", "arg1_id": "NCT02951832_inc_T5", "arg2_id": "NCT02951832_inc_T9", "normalized": [] } ]

[ { "id": "NCT02952365_exc_text", "type": "exclusion", "text": [ "Subjects under the age of 21.\nSubjects with excessively thin corneas.\nSubjects with topographic evidence of keratoconus.\nSubjects with ectatic eye disorders.\nSubjects with autoimmune diseases.\nSubjects who are pregnant or nursing.\n" ], "offsets": [ [ 0, 231 ] ] } ]

[ { "id": "NCT02952365_exc_T1", "type": "Value", "text": [ "under the age of 21" ], "offsets": [ [ 9, 28 ] ], "normalized": [] }, { "id": "NCT02952365_exc_T2", "type": "Person", "text": [ "age" ], "offsets": [ [ 19, 22 ] ], "normalized": [] }, { "id": "NCT02952365_exc_T3", "type": "Condition", "text": [ "excessively thin corneas" ], "offsets": [ [ 44, 68 ] ], "normalized": [] }, { "id": "NCT02952365_exc_T4", "type": "Condition", "text": [ "topographic evidence" ], "offsets": [ [ 84, 104 ] ], "normalized": [] }, { "id": "NCT02952365_exc_T5", "type": "Condition", "text": [ "keratoconus" ], "offsets": [ [ 108, 119 ] ], "normalized": [] }, { "id": "NCT02952365_exc_T6", "type": "Condition", "text": [ "ectatic eye disorders" ], "offsets": [ [ 135, 156 ] ], "normalized": [] }, { "id": "NCT02952365_exc_T7", "type": "Condition", "text": [ "autoimmune diseases" ], "offsets": [ [ 172, 191 ] ], "normalized": [] }, { "id": "NCT02952365_exc_T8", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 210, 218 ] ], "normalized": [] }, { "id": "NCT02952365_exc_T9", "type": "Condition", "text": [ "nursing" ], "offsets": [ [ 222, 229 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02952365_exc_R1", "type": "Has_value", "arg1_id": "NCT02952365_exc_T2", "arg2_id": "NCT02952365_exc_T1", "normalized": [] }, { "id": "NCT02952365_exc_R2", "type": "AND", "arg1_id": "NCT02952365_exc_T4", "arg2_id": "NCT02952365_exc_T5", "normalized": [] } ]

[ { "id": "NCT02952365_inc_text", "type": "inclusion", "text": [ "Subjects age 21 and older\nSubjects with healthy eyes\nSubjects who have previously undergone LASIK surgery\nSubjects with residual refractive error.\n" ], "offsets": [ [ 0, 147 ] ] } ]

[ { "id": "NCT02952365_inc_T1", "type": "Value", "text": [ "21 and older" ], "offsets": [ [ 13, 25 ] ], "normalized": [] }, { "id": "NCT02952365_inc_T2", "type": "Person", "text": [ "age" ], "offsets": [ [ 9, 12 ] ], "normalized": [] }, { "id": "NCT02952365_inc_T3", "type": "Condition", "text": [ "healthy eyes" ], "offsets": [ [ 40, 52 ] ], "normalized": [] }, { "id": "NCT02952365_inc_T4", "type": "Procedure", "text": [ "LASIK surgery" ], "offsets": [ [ 92, 105 ] ], "normalized": [] }, { "id": "NCT02952365_inc_T5", "type": "Temporal", "text": [ "previously" ], "offsets": [ [ 71, 81 ] ], "normalized": [] }, { "id": "NCT02952365_inc_T6", "type": "Condition", "text": [ "residual refractive error" ], "offsets": [ [ 120, 145 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02952365_inc_R1", "type": "AND", "arg1_id": "NCT02952365_inc_T1", "arg2_id": "NCT02952365_inc_T2", "normalized": [] }, { "id": "NCT02952365_inc_R2", "type": "Has_temporal", "arg1_id": "NCT02952365_inc_T4", "arg2_id": "NCT02952365_inc_T5", "normalized": [] } ]

[ { "id": "NCT02952378_exc_text", "type": "exclusion", "text": [ "Heart failure\nSigns of kidney injury/failure\nSevere allergies\n" ], "offsets": [ [ 0, 62 ] ] } ]

[ { "id": "NCT02952378_exc_T1", "type": "Condition", "text": [ "Heart failure" ], "offsets": [ [ 0, 13 ] ], "normalized": [] }, { "id": "NCT02952378_exc_T2", "type": "Condition", "text": [ "kidney injury" ], "offsets": [ [ 23, 36 ] ], "normalized": [] }, { "id": "NCT02952378_exc_T3", "type": "Condition", "text": [ "idney", "ailure" ], "offsets": [ [ 24, 29 ], [ 38, 44 ] ], "normalized": [] }, { "id": "NCT02952378_exc_T4", "type": "Mood", "text": [ "Signs of" ], "offsets": [ [ 14, 22 ] ], "normalized": [] }, { "id": "NCT02952378_exc_T5", "type": "Scope", "text": [ "kidney injury/failure" ], "offsets": [ [ 23, 44 ] ], "normalized": [] }, { "id": "NCT02952378_exc_T6", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 45, 51 ] ], "normalized": [] }, { "id": "NCT02952378_exc_T7", "type": "Condition", "text": [ "allergies" ], "offsets": [ [ 52, 61 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02952378_exc_R1", "type": "Has_mood", "arg1_id": "NCT02952378_exc_T5", "arg2_id": "NCT02952378_exc_T4", "normalized": [] }, { "id": "NCT02952378_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02952378_exc_T7", "arg2_id": "NCT02952378_exc_T6", "normalized": [] } ]

[ { "id": "NCT02952378_inc_text", "type": "inclusion", "text": [ "For healthy individuals: Healthy, without allergies and with the age of 18 years or above.\nFor patients: Burn injury exceeding 6-8 Total Burned Surface Area %\n" ], "offsets": [ [ 0, 159 ] ] } ]

[ { "id": "NCT02952378_inc_T1", "type": "Condition", "text": [ "Healthy" ], "offsets": [ [ 25, 32 ] ], "normalized": [] }, { "id": "NCT02952378_inc_T2", "type": "Condition", "text": [ "healthy" ], "offsets": [ [ 4, 11 ] ], "normalized": [] }, { "id": "NCT02952378_inc_T3", "type": "Person", "text": [ "patients" ], "offsets": [ [ 95, 103 ] ], "normalized": [] }, { "id": "NCT02952378_inc_T4", "type": "Negation", "text": [ "without" ], "offsets": [ [ 34, 41 ] ], "normalized": [] }, { "id": "NCT02952378_inc_T5", "type": "Condition", "text": [ "allergies" ], "offsets": [ [ 42, 51 ] ], "normalized": [] }, { "id": "NCT02952378_inc_T6", "type": "Value", "text": [ "18 years or above" ], "offsets": [ [ 72, 89 ] ], "normalized": [] }, { "id": "NCT02952378_inc_T7", "type": "Person", "text": [ "age" ], "offsets": [ [ 65, 68 ] ], "normalized": [] }, { "id": "NCT02952378_inc_T8", "type": "Scope", "text": [ "Healthy, without allergies and with the age of 18 years or above" ], "offsets": [ [ 25, 89 ] ], "normalized": [] }, { "id": "NCT02952378_inc_T9", "type": "Condition", "text": [ "Burn injury" ], "offsets": [ [ 105, 116 ] ], "normalized": [] }, { "id": "NCT02952378_inc_T10", "type": "Value", "text": [ "xceeding 6-8", "" ], "offsets": [ [ 118, 130 ], [ 158, 158 ] ], "normalized": [] }, { "id": "NCT02952378_inc_T11", "type": "Measurement", "text": [ "Total Burned Surface Area" ], "offsets": [ [ 131, 156 ] ], "normalized": [] }, { "id": "NCT02952378_inc_T12", "type": "Scope", "text": [ "Burn injury exceeding 6-8 Total Burned Surface Area %" ], "offsets": [ [ 105, 158 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02952378_inc_R1", "type": "Has_value", "arg1_id": "NCT02952378_inc_T7", "arg2_id": "NCT02952378_inc_T6", "normalized": [] }, { "id": "NCT02952378_inc_R2", "type": "Has_negation", "arg1_id": "NCT02952378_inc_T5", "arg2_id": "NCT02952378_inc_T4", "normalized": [] }, { "id": "NCT02952378_inc_R3", "type": "Has_scope", "arg1_id": "NCT02952378_inc_T2", "arg2_id": "NCT02952378_inc_T8", "normalized": [] }, { "id": "NCT02952378_inc_R4", "type": "Has_value", "arg1_id": "NCT02952378_inc_T11", "arg2_id": "NCT02952378_inc_T10", "normalized": [] }, { "id": "NCT02952378_inc_R5", "type": "Has_scope", "arg1_id": "NCT02952378_inc_T3", "arg2_id": "NCT02952378_inc_T12", "normalized": [] } ]

[ { "id": "NCT02952963_exc_text", "type": "exclusion", "text": [ "Fasting plasma glucose > 7,0 mM, HbA1c > 48 mmol/mol 3 months after RYGB\nDysregulated thyroid diseases, use of antithyroid treatment.\nLate diabetic complications as retinopathy, renal insufficiency, neuropathy or previous pancreatitis.\nComplications to RYGB. Documented reactive hypoglycaemia, severe dumping (vomiting, diarrhea, severe abdominal pain after food intake)\nCholecystectomy.\n" ], "offsets": [ [ 0, 388 ] ] } ]

[ { "id": "NCT02952963_exc_T1", "type": "Measurement", "text": [ "Fasting plasma glucose" ], "offsets": [ [ 0, 22 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T2", "type": "Value", "text": [ "> 7,0 mM" ], "offsets": [ [ 23, 31 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T3", "type": "Measurement", "text": [ "HbA1c" ], "offsets": [ [ 33, 38 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T4", "type": "Value", "text": [ "> 48 mmol/mol" ], "offsets": [ [ 39, 52 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T5", "type": "Temporal", "text": [ "3 months after RYGB" ], "offsets": [ [ 53, 72 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T6", "type": "Scope", "text": [ "Fasting plasma glucose > 7,0 mM, HbA1c > 48 mmol/mol" ], "offsets": [ [ 0, 52 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T7", "type": "Qualifier", "text": [ "Dysregulated" ], "offsets": [ [ 73, 85 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T8", "type": "Condition", "text": [ "thyroid diseases" ], "offsets": [ [ 86, 102 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T9", "type": "Procedure", "text": [ "antithyroid treatment" ], "offsets": [ [ 111, 132 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T10", "type": "Condition", "text": [ "Late diabetic complications" ], "offsets": [ [ 134, 161 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T11", "type": "Condition", "text": [ "retinopathy" ], "offsets": [ [ 165, 176 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T12", "type": "Condition", "text": [ "renal insufficiency" ], "offsets": [ [ 178, 197 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T13", "type": "Condition", "text": [ "neuropathy" ], "offsets": [ [ 199, 209 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T14", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 213, 221 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T15", "type": "Condition", "text": [ "pancreatitis" ], "offsets": [ [ 222, 234 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T16", "type": "Scope", "text": [ "retinopathy, renal insufficiency, neuropathy or previous pancreatitis" ], "offsets": [ [ 165, 234 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T17", "type": "Condition", "text": [ "Complications" ], "offsets": [ [ 236, 249 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T18", "type": "Procedure", "text": [ "RYGB" ], "offsets": [ [ 253, 257 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T19", "type": "Condition", "text": [ "reactive hypoglycaemia" ], "offsets": [ [ 270, 292 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T20", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 294, 300 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T21", "type": "Condition", "text": [ "dumping" ], "offsets": [ [ 301, 308 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T22", "type": "Condition", "text": [ "vomiting" ], "offsets": [ [ 310, 318 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T23", "type": "Condition", "text": [ "diarrhea" ], "offsets": [ [ 320, 328 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T24", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 330, 336 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T25", "type": "Condition", "text": [ "abdominal pain" ], "offsets": [ [ 337, 351 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T26", "type": "Temporal", "text": [ "after food intake" ], "offsets": [ [ 352, 369 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T27", "type": "Reference_point", "text": [ "food intake" ], "offsets": [ [ 358, 369 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T28", "type": "Scope", "text": [ "vomiting, diarrhea, severe abdominal pain after food intake" ], "offsets": [ [ 310, 369 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T29", "type": "Scope", "text": [ "severe dumping" ], "offsets": [ [ 294, 308 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T30", "type": "Scope", "text": [ "reactive hypoglycaemia, severe dumping (vomiting, diarrhea, severe abdominal pain after food intake)" ], "offsets": [ [ 270, 370 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T31", "type": "Scope", "text": [ "Complications to RYGB" ], "offsets": [ [ 236, 257 ] ], "normalized": [] }, { "id": "NCT02952963_exc_T32", "type": "Procedure", "text": [ "Cholecystectomy" ], "offsets": [ [ 371, 386 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02952963_exc_R1", "type": "Has_value", "arg1_id": "NCT02952963_exc_T1", "arg2_id": "NCT02952963_exc_T2", "normalized": [] }, { "id": "NCT02952963_exc_R2", "type": "Has_value", "arg1_id": "NCT02952963_exc_T3", "arg2_id": "NCT02952963_exc_T4", "normalized": [] }, { "id": "NCT02952963_exc_R3", "type": "Has_temporal", "arg1_id": "NCT02952963_exc_T6", "arg2_id": "NCT02952963_exc_T5", "normalized": [] }, { "id": "NCT02952963_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT02952963_exc_T8", "arg2_id": "NCT02952963_exc_T7", "normalized": [] }, { "id": "NCT02952963_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02952963_exc_T15", "arg2_id": "NCT02952963_exc_T14", "normalized": [] }, { "id": "NCT02952963_exc_R6", "type": "Subsumes", "arg1_id": "NCT02952963_exc_T10", "arg2_id": "NCT02952963_exc_T16", "normalized": [] }, { "id": "NCT02952963_exc_R7", "type": "AND", "arg1_id": "NCT02952963_exc_T17", "arg2_id": "NCT02952963_exc_T18", "normalized": [] }, { "id": "NCT02952963_exc_R8", "type": "Has_index", "arg1_id": "NCT02952963_exc_T26", "arg2_id": "NCT02952963_exc_T27", "normalized": [] }, { "id": "NCT02952963_exc_R9", "type": "Has_temporal", "arg1_id": "NCT02952963_exc_T25", "arg2_id": "NCT02952963_exc_T26", "normalized": [] }, { "id": "NCT02952963_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT02952963_exc_T25", "arg2_id": "NCT02952963_exc_T24", "normalized": [] }, { "id": "NCT02952963_exc_R11", "type": "Has_qualifier", "arg1_id": "NCT02952963_exc_T21", "arg2_id": "NCT02952963_exc_T20", "normalized": [] }, { "id": "NCT02952963_exc_R12", "type": "Subsumes", "arg1_id": "NCT02952963_exc_T29", "arg2_id": "NCT02952963_exc_T28", "normalized": [] }, { "id": "NCT02952963_exc_R13", "type": "Subsumes", "arg1_id": "NCT02952963_exc_T31", "arg2_id": "NCT02952963_exc_T30", "normalized": [] } ]

[ { "id": "NCT02952963_inc_text", "type": "inclusion", "text": [ "Uncomplicated RYGB performed minimum 3 months prior to the study.\nFasting glucose < 7,0 mM, HbA1c < 48 mmol/mol 3 months after RYGB\n" ], "offsets": [ [ 0, 132 ] ] } ]

[ { "id": "NCT02952963_inc_T1", "type": "Qualifier", "text": [ "Uncomplicated" ], "offsets": [ [ 0, 13 ] ], "normalized": [] }, { "id": "NCT02952963_inc_T2", "type": "Procedure", "text": [ "RYGB" ], "offsets": [ [ 14, 18 ] ], "normalized": [] }, { "id": "NCT02952963_inc_T3", "type": "Temporal", "text": [ "minimum 3 months prior to the study" ], "offsets": [ [ 29, 64 ] ], "normalized": [] }, { "id": "NCT02952963_inc_T4", "type": "Reference_point", "text": [ "the study" ], "offsets": [ [ 55, 64 ] ], "normalized": [] }, { "id": "NCT02952963_inc_T5", "type": "Measurement", "text": [ "Fasting glucose" ], "offsets": [ [ 66, 81 ] ], "normalized": [] }, { "id": "NCT02952963_inc_T6", "type": "Value", "text": [ "< 7,0 mM" ], "offsets": [ [ 82, 90 ] ], "normalized": [] }, { "id": "NCT02952963_inc_T7", "type": "Measurement", "text": [ "HbA1c" ], "offsets": [ [ 92, 97 ] ], "normalized": [] }, { "id": "NCT02952963_inc_T8", "type": "Value", "text": [ "< 48 mmol/mol" ], "offsets": [ [ 98, 111 ] ], "normalized": [] }, { "id": "NCT02952963_inc_T9", "type": "Temporal", "text": [ "3 months after RYGB" ], "offsets": [ [ 112, 131 ] ], "normalized": [] }, { "id": "NCT02952963_inc_T10", "type": "Reference_point", "text": [ "RYGB" ], "offsets": [ [ 127, 131 ] ], "normalized": [] }, { "id": "NCT02952963_inc_T11", "type": "Procedure", "text": [ "RYGB" ], "offsets": [ [ 127, 131 ] ], "normalized": [] }, { "id": "NCT02952963_inc_T12", "type": "Scope", "text": [ "Fasting glucose < 7,0 mM, HbA1c < 48 mmol/mol" ], "offsets": [ [ 66, 111 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02952963_inc_R1", "type": "Has_index", "arg1_id": "NCT02952963_inc_T3", "arg2_id": "NCT02952963_inc_T4", "normalized": [] }, { "id": "NCT02952963_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02952963_inc_T2", "arg2_id": "NCT02952963_inc_T1", "normalized": [] }, { "id": "NCT02952963_inc_R3", "type": "Has_temporal", "arg1_id": "NCT02952963_inc_T2", "arg2_id": "NCT02952963_inc_T3", "normalized": [] }, { "id": "NCT02952963_inc_R5", "type": "Has_index", "arg1_id": "NCT02952963_inc_T9", "arg2_id": "NCT02952963_inc_T10", "normalized": [] }, { "id": "NCT02952963_inc_R6", "type": "Has_value", "arg1_id": "NCT02952963_inc_T7", "arg2_id": "NCT02952963_inc_T8", "normalized": [] }, { "id": "NCT02952963_inc_R7", "type": "Has_value", "arg1_id": "NCT02952963_inc_T5", "arg2_id": "NCT02952963_inc_T6", "normalized": [] }, { "id": "NCT02952963_inc_R8", "type": "Has_temporal", "arg1_id": "NCT02952963_inc_T12", "arg2_id": "NCT02952963_inc_T9", "normalized": [] } ]

[ { "id": "NCT02953873_exc_text", "type": "exclusion", "text": [ "NA\n\n" ], "offsets": [ [ 0, 4 ] ] } ]

[]

[]

[]

[]

[ { "id": "NCT02953873_inc_text", "type": "inclusion", "text": [ "At least 18 years of age\nSigned informed consent\nAfrican American race\nHistory of a solitary renal transplant\nStable tacrolimus dose for at least 2 weeks prior to randomization\n" ], "offsets": [ [ 0, 177 ] ] } ]

[ { "id": "NCT02953873_inc_T1", "type": "Person", "text": [ "age" ], "offsets": [ [ 21, 24 ] ], "normalized": [] }, { "id": "NCT02953873_inc_T2", "type": "Value", "text": [ "At least 18 years" ], "offsets": [ [ 0, 17 ] ], "normalized": [] }, { "id": "NCT02953873_inc_T4", "type": "Person", "text": [ "race" ], "offsets": [ [ 66, 70 ] ], "normalized": [] }, { "id": "NCT02953873_inc_T5", "type": "Value", "text": [ "African American" ], "offsets": [ [ 49, 65 ] ], "normalized": [] }, { "id": "NCT02953873_inc_T6", "type": "Procedure", "text": [ "renal transplant" ], "offsets": [ [ 93, 109 ] ], "normalized": [] }, { "id": "NCT02953873_inc_T7", "type": "Qualifier", "text": [ "solitary" ], "offsets": [ [ 84, 92 ] ], "normalized": [] }, { "id": "NCT02953873_inc_T8", "type": "Drug", "text": [ "tacrolimus" ], "offsets": [ [ 117, 127 ] ], "normalized": [] }, { "id": "NCT02953873_inc_T9", "type": "Temporal", "text": [ "for at least 2 weeks prior to randomization" ], "offsets": [ [ 133, 176 ] ], "normalized": [] }, { "id": "NCT02953873_inc_T10", "type": "Reference_point", "text": [ "randomization" ], "offsets": [ [ 163, 176 ] ], "normalized": [] }, { "id": "NCT02953873_inc_T11", "type": "Qualifier", "text": [ "le tac", " fo" ], "offsets": [ [ 114, 120 ], [ 132, 135 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02953873_inc_R1", "type": "Has_value", "arg1_id": "NCT02953873_inc_T1", "arg2_id": "NCT02953873_inc_T2", "normalized": [] }, { "id": "NCT02953873_inc_R2", "type": "Has_value", "arg1_id": "NCT02953873_inc_T4", "arg2_id": "NCT02953873_inc_T5", "normalized": [] }, { "id": "NCT02953873_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT02953873_inc_T6", "arg2_id": "NCT02953873_inc_T7", "normalized": [] }, { "id": "NCT02953873_inc_R4", "type": "Has_index", "arg1_id": "NCT02953873_inc_T9", "arg2_id": "NCT02953873_inc_T10", "normalized": [] }, { "id": "NCT02953873_inc_R5", "type": "Has_temporal", "arg1_id": "NCT02953873_inc_T8", "arg2_id": "NCT02953873_inc_T9", "normalized": [] }, { "id": "NCT02953873_inc_R6", "type": "Has_qualifier", "arg1_id": "NCT02953873_inc_T8", "arg2_id": "NCT02953873_inc_T11", "normalized": [] } ]

[ { "id": "NCT02954029_exc_text", "type": "exclusion", "text": [ "congenital or acquired bleeding tendency\nplatelet count <50,000/ µL\nhypersensitivity to shrimps, lobsters or beetles\n" ], "offsets": [ [ 0, 117 ] ] } ]

[ { "id": "NCT02954029_exc_T1", "type": "Qualifier", "text": [ "acquired" ], "offsets": [ [ 14, 22 ] ], "normalized": [] }, { "id": "NCT02954029_exc_T2", "type": "Qualifier", "text": [ "congenital" ], "offsets": [ [ 0, 10 ] ], "normalized": [] }, { "id": "NCT02954029_exc_T3", "type": "Condition", "text": [ "bleeding tendency" ], "offsets": [ [ 23, 40 ] ], "normalized": [] }, { "id": "NCT02954029_exc_T4", "type": "Scope", "text": [ "congenital or acquired" ], "offsets": [ [ 0, 22 ] ], "normalized": [] }, { "id": "NCT02954029_exc_T5", "type": "Measurement", "text": [ "platelet count" ], "offsets": [ [ 41, 55 ] ], "normalized": [] }, { "id": "NCT02954029_exc_T6", "type": "Value", "text": [ "<50,000/ µL" ], "offsets": [ [ 56, 67 ] ], "normalized": [] }, { "id": "NCT02954029_exc_T7", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 68, 84 ] ], "normalized": [] }, { "id": "NCT02954029_exc_T8", "type": "Qualifier", "text": [ "shrimps" ], "offsets": [ [ 88, 95 ] ], "normalized": [] }, { "id": "NCT02954029_exc_T9", "type": "Qualifier", "text": [ "lobsters" ], "offsets": [ [ 97, 105 ] ], "normalized": [] }, { "id": "NCT02954029_exc_T10", "type": "Qualifier", "text": [ "beetles" ], "offsets": [ [ 109, 116 ] ], "normalized": [] }, { "id": "NCT02954029_exc_T11", "type": "Scope", "text": [ "shrimps, lobsters or beetles" ], "offsets": [ [ 88, 116 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02954029_exc_R1", "type": "Has_scope", "arg1_id": "NCT02954029_exc_T3", "arg2_id": "NCT02954029_exc_T4", "normalized": [] }, { "id": "NCT02954029_exc_R2", "type": "Has_value", "arg1_id": "NCT02954029_exc_T5", "arg2_id": "NCT02954029_exc_T6", "normalized": [] }, { "id": "NCT02954029_exc_R3", "type": "Has_scope", "arg1_id": "NCT02954029_exc_T7", "arg2_id": "NCT02954029_exc_T11", "normalized": [] } ]

[ { "id": "NCT02954029_inc_text", "type": "inclusion", "text": [ "age 18 years or older\npatients undergoing invasive procedures via the radial or femoral arteries\n" ], "offsets": [ [ 0, 97 ] ] } ]

[ { "id": "NCT02954029_inc_T1", "type": "Person", "text": [ "age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02954029_inc_T2", "type": "Value", "text": [ "18 years or older" ], "offsets": [ [ 4, 21 ] ], "normalized": [] }, { "id": "NCT02954029_inc_T3", "type": "Procedure", "text": [ "invasive procedures" ], "offsets": [ [ 42, 61 ] ], "normalized": [] }, { "id": "NCT02954029_inc_T4", "type": "Temporal", "text": [ "undergoing" ], "offsets": [ [ 31, 41 ] ], "normalized": [] }, { "id": "NCT02954029_inc_T5", "type": "Qualifier", "text": [ "adial", "rteries" ], "offsets": [ [ 71, 76 ], [ 89, 96 ] ], "normalized": [] }, { "id": "NCT02954029_inc_T6", "type": "Qualifier", "text": [ "femoral arteries" ], "offsets": [ [ 80, 96 ] ], "normalized": [] }, { "id": "NCT02954029_inc_T7", "type": "Scope", "text": [ "radial or femoral arteries" ], "offsets": [ [ 70, 96 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02954029_inc_R1", "type": "Has_value", "arg1_id": "NCT02954029_inc_T1", "arg2_id": "NCT02954029_inc_T2", "normalized": [] }, { "id": "NCT02954029_inc_R2", "type": "Has_temporal", "arg1_id": "NCT02954029_inc_T3", "arg2_id": "NCT02954029_inc_T4", "normalized": [] }, { "id": "NCT02954029_inc_R3", "type": "Has_scope", "arg1_id": "NCT02954029_inc_T3", "arg2_id": "NCT02954029_inc_T7", "normalized": [] } ]

[ { "id": "NCT02957305_exc_text", "type": "exclusion", "text": [ "patients who do not wish to participate in the project;\npatients with ectopic pregnancy;\npatients with comorbidities (heart failure congestive, chronic obstructive pulmonary disease);\npatients with hypovolemic shock;\npatients with cervical incompetence;\npatients with infected miscarriage/abortion (presence of fever, pus from the cervix, leukocytosis [> 14000]);\npatients with twin pregnancy;\npatients with Marfan syndrome;\npatients allergic to misoprostol;\npatients with coagulopathy;\npatients with opening of cervical internal os (4 mm of dilatation at the time of consultation);\npatients with previous surgery of the cervix (conization);\npatients with concomitant use of IUDs.\n" ], "offsets": [ [ 0, 681 ] ] } ]

[ { "id": "NCT02957305_exc_T2", "type": "Condition", "text": [ "ectopic pregnancy" ], "offsets": [ [ 70, 87 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T3", "type": "Condition", "text": [ "comorbidities" ], "offsets": [ [ 103, 116 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T4", "type": "Condition", "text": [ "heart failure congestive" ], "offsets": [ [ 118, 142 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T5", "type": "Condition", "text": [ "chronic obstructive pulmonary disease" ], "offsets": [ [ 144, 181 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T6", "type": "Scope", "text": [ "heart failure congestive, chronic obstructive pulmonary disease" ], "offsets": [ [ 118, 181 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T7", "type": "Condition", "text": [ "hypovolemic shock" ], "offsets": [ [ 198, 215 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T8", "type": "Condition", "text": [ "cervical incompetence" ], "offsets": [ [ 231, 252 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T9", "type": "Qualifier", "text": [ "infected" ], "offsets": [ [ 268, 276 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T10", "type": "Condition", "text": [ "abortion" ], "offsets": [ [ 289, 297 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T11", "type": "Condition", "text": [ "miscarriage" ], "offsets": [ [ 277, 288 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T12", "type": "Scope", "text": [ "miscarriage/abortion" ], "offsets": [ [ 277, 297 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T13", "type": "Condition", "text": [ "fever" ], "offsets": [ [ 311, 316 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T14", "type": "Condition", "text": [ "pus from the cervix" ], "offsets": [ [ 318, 337 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T15", "type": "Measurement", "text": [ "leukocytosis" ], "offsets": [ [ 339, 351 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T16", "type": "Temporal", "text": [ "> 14000" ], "offsets": [ [ 353, 360 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T17", "type": "Scope", "text": [ "fever, pus from the cervix, leukocytosis [> 14000]" ], "offsets": [ [ 311, 361 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T18", "type": "Qualifier", "text": [ "twin" ], "offsets": [ [ 378, 382 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T19", "type": "Condition", "text": [ "pregnancy" ], "offsets": [ [ 383, 392 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T20", "type": "Condition", "text": [ "Marfan syndrome" ], "offsets": [ [ 408, 423 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T21", "type": "Condition", "text": [ "allergic" ], "offsets": [ [ 434, 442 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T22", "type": "Drug", "text": [ "misoprostol" ], "offsets": [ [ 446, 457 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T23", "type": "Condition", "text": [ "coagulopathy" ], "offsets": [ [ 473, 485 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T24", "type": "Observation", "text": [ "opening of cervical internal os" ], "offsets": [ [ 501, 532 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T25", "type": "Value", "text": [ "4 mm of dilatation" ], "offsets": [ [ 534, 552 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T26", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 606, 613 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T27", "type": "Qualifier", "text": [ "cervix" ], "offsets": [ [ 621, 627 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T28", "type": "Procedure", "text": [ "conization" ], "offsets": [ [ 629, 639 ] ], "normalized": [] }, { "id": "NCT02957305_exc_T29", "type": "Drug", "text": [ "IUDs" ], "offsets": [ [ 675, 679 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02957305_exc_R1", "type": "Subsumes", "arg1_id": "NCT02957305_exc_T3", "arg2_id": "NCT02957305_exc_T6", "normalized": [] }, { "id": "NCT02957305_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02957305_exc_T12", "arg2_id": "NCT02957305_exc_T9", "normalized": [] }, { "id": "NCT02957305_exc_R3", "type": "Has_temporal", "arg1_id": "NCT02957305_exc_T15", "arg2_id": "NCT02957305_exc_T16", "normalized": [] }, { "id": "NCT02957305_exc_R4", "type": "Has_scope", "arg1_id": "NCT02957305_exc_T12", "arg2_id": "NCT02957305_exc_T17", "normalized": [] }, { "id": "NCT02957305_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02957305_exc_T19", "arg2_id": "NCT02957305_exc_T18", "normalized": [] }, { "id": "NCT02957305_exc_R6", "type": "AND", "arg1_id": "NCT02957305_exc_T21", "arg2_id": "NCT02957305_exc_T22", "normalized": [] }, { "id": "NCT02957305_exc_R7", "type": "Has_value", "arg1_id": "NCT02957305_exc_T24", "arg2_id": "NCT02957305_exc_T25", "normalized": [] }, { "id": "NCT02957305_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT02957305_exc_T26", "arg2_id": "NCT02957305_exc_T27", "normalized": [] }, { "id": "NCT02957305_exc_R9", "type": "Subsumes", "arg1_id": "NCT02957305_exc_T26", "arg2_id": "NCT02957305_exc_T28", "normalized": [] } ]

[ { "id": "NCT02957305_inc_text", "type": "inclusion", "text": [ "All patients admitted at the Gynecological emergency Unit at Hospital de Clínicas de Porto Alegre scheduled for uterine evacuation with <12 weeks of gestation.\n" ], "offsets": [ [ 0, 160 ] ] } ]

[ { "id": "NCT02957305_inc_T1", "type": "Visit", "text": [ "Gynecological emergency Unit at Hospital de Clínicas de Porto Alegre" ], "offsets": [ [ 29, 97 ] ], "normalized": [] }, { "id": "NCT02957305_inc_T2", "type": "Procedure", "text": [ "uterine evacuation" ], "offsets": [ [ 112, 130 ] ], "normalized": [] }, { "id": "NCT02957305_inc_T3", "type": "Condition", "text": [ "gestation" ], "offsets": [ [ 149, 158 ] ], "normalized": [] }, { "id": "NCT02957305_inc_T4", "type": "Multiplier", "text": [ "<12 weeks" ], "offsets": [ [ 136, 145 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02957305_inc_R1", "type": "Has_multiplier", "arg1_id": "NCT02957305_inc_T3", "arg2_id": "NCT02957305_inc_T4", "normalized": [] }, { "id": "NCT02957305_inc_R2", "type": "AND", "arg1_id": "NCT02957305_inc_T2", "arg2_id": "NCT02957305_inc_T3", "normalized": [] } ]

[ { "id": "NCT02957877_exc_text", "type": "exclusion", "text": [ "History of intolerance to LMWHs during HD\nReceiving warfarin or other oral anticoagulant\nPregnant patients\n" ], "offsets": [ [ 0, 107 ] ] } ]

[ { "id": "NCT02957877_exc_T1", "type": "Condition", "text": [ "intolerance" ], "offsets": [ [ 11, 22 ] ], "normalized": [] }, { "id": "NCT02957877_exc_T2", "type": "Drug", "text": [ "LMWHs" ], "offsets": [ [ 26, 31 ] ], "normalized": [] }, { "id": "NCT02957877_exc_T3", "type": "Procedure", "text": [ "HD" ], "offsets": [ [ 39, 41 ] ], "normalized": [] }, { "id": "NCT02957877_exc_T4", "type": "Temporal", "text": [ "during HD" ], "offsets": [ [ 32, 41 ] ], "normalized": [] }, { "id": "NCT02957877_exc_T5", "type": "Drug", "text": [ "warfarin" ], "offsets": [ [ 52, 60 ] ], "normalized": [] }, { "id": "NCT02957877_exc_T6", "type": "Condition", "text": [ "oral anticoagulant" ], "offsets": [ [ 70, 88 ] ], "normalized": [] }, { "id": "NCT02957877_exc_T7", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 64, 69 ] ], "normalized": [] }, { "id": "NCT02957877_exc_T8", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 89, 97 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02957877_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02957877_exc_T2", "arg2_id": "NCT02957877_exc_T4", "normalized": [] }, { "id": "NCT02957877_exc_R3", "type": "AND", "arg1_id": "NCT02957877_exc_T1", "arg2_id": "NCT02957877_exc_T2", "normalized": [] }, { "id": "NCT02957877_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT02957877_exc_T6", "arg2_id": "NCT02957877_exc_T7", "normalized": [] } ]

[ { "id": "NCT02957877_inc_text", "type": "inclusion", "text": [ "Prevalent NHHD patients who have received >1 year dialysis with unfractionated heparin as anticoagulant\nAge >= 18\nInformed consent available\n" ], "offsets": [ [ 0, 141 ] ] } ]

[ { "id": "NCT02957877_inc_T1", "type": "Condition", "text": [ "NHHD" ], "offsets": [ [ 10, 14 ] ], "normalized": [] }, { "id": "NCT02957877_inc_T2", "type": "Temporal", "text": [ ">1 year" ], "offsets": [ [ 42, 49 ] ], "normalized": [] }, { "id": "NCT02957877_inc_T3", "type": "Procedure", "text": [ "dialysis" ], "offsets": [ [ 50, 58 ] ], "normalized": [] }, { "id": "NCT02957877_inc_T4", "type": "Drug", "text": [ "unfractionated heparin" ], "offsets": [ [ 64, 86 ] ], "normalized": [] }, { "id": "NCT02957877_inc_T5", "type": "Drug", "text": [ "anticoagulant" ], "offsets": [ [ 90, 103 ] ], "normalized": [] }, { "id": "NCT02957877_inc_T6", "type": "Person", "text": [ "Age" ], "offsets": [ [ 104, 107 ] ], "normalized": [] }, { "id": "NCT02957877_inc_T7", "type": "Value", "text": [ ">= 18" ], "offsets": [ [ 108, 113 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02957877_inc_R1", "type": "Subsumes", "arg1_id": "NCT02957877_inc_T4", "arg2_id": "NCT02957877_inc_T5", "normalized": [] }, { "id": "NCT02957877_inc_R2", "type": "AND", "arg1_id": "NCT02957877_inc_T3", "arg2_id": "NCT02957877_inc_T4", "normalized": [] }, { "id": "NCT02957877_inc_R3", "type": "Has_temporal", "arg1_id": "NCT02957877_inc_T3", "arg2_id": "NCT02957877_inc_T2", "normalized": [] }, { "id": "NCT02957877_inc_R4", "type": "Has_value", "arg1_id": "NCT02957877_inc_T6", "arg2_id": "NCT02957877_inc_T7", "normalized": [] } ]

[ { "id": "NCT02958072_exc_text", "type": "exclusion", "text": [ "Hemoglobin concentration under 6.5 mmol/l screening \nHBA1c more than 108 mmol/l \nNon-compliant with blood-letting \nClinically infected ulcer \nPatient planned for or has had a revascularization procedure in the affected leg within the last 8 weeks \nThe ulcer have been treated with growth factors in the last 8 weeks \nHistory of deep venous insufficiency, chronic venous leg ulcer or stasis dermatitis \nBreast-feeding women or fertile women not agreeing to use an effective method of contraception \nParticipation in another clinical ulcer-healing study within the last 4 weeks \nPatient has previously been randomized in this study \nJudgement by the investigator that the patient is not able to participate in the study \n \n" ], "offsets": [ [ 0, 730 ] ] } ]

[ { "id": "NCT02958072_exc_T1", "type": "Measurement", "text": [ "Hemoglobin concentration" ], "offsets": [ [ 0, 24 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T2", "type": "Value", "text": [ "under 6.5 mmol/l" ], "offsets": [ [ 25, 41 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T3", "type": "Measurement", "text": [ "HBA1c" ], "offsets": [ [ 53, 58 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T4", "type": "Value", "text": [ "more than 108 mmol/l" ], "offsets": [ [ 59, 79 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T5", "type": "Condition", "text": [ "Non-compliant" ], "offsets": [ [ 81, 94 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T6", "type": "Procedure", "text": [ "blood-letting" ], "offsets": [ [ 100, 113 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T8", "type": "Condition", "text": [ "infected ulcer" ], "offsets": [ [ 126, 140 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T9", "type": "Procedure", "text": [ "revascularization procedure" ], "offsets": [ [ 175, 202 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T10", "type": "Reference_point", "text": [ "affected leg" ], "offsets": [ [ 210, 222 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T11", "type": "Temporal", "text": [ "within the last 8 weeks" ], "offsets": [ [ 223, 246 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T12", "type": "Observation", "text": [ "planned" ], "offsets": [ [ 150, 157 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T13", "type": "Observation", "text": [ "has had" ], "offsets": [ [ 165, 172 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T14", "type": "Scope", "text": [ "planned for or has had" ], "offsets": [ [ 150, 172 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T15", "type": "Condition", "text": [ "ulcer" ], "offsets": [ [ 252, 257 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T16", "type": "Procedure", "text": [ "treated" ], "offsets": [ [ 268, 275 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T17", "type": "Drug", "text": [ "growth factors" ], "offsets": [ [ 281, 295 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T18", "type": "Temporal", "text": [ "in the last 8 weeks" ], "offsets": [ [ 296, 315 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T19", "type": "Condition", "text": [ "deep venous insufficiency" ], "offsets": [ [ 328, 353 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T20", "type": "Condition", "text": [ "chronic venous leg ulcer" ], "offsets": [ [ 355, 379 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T21", "type": "Condition", "text": [ "stasis dermatitis" ], "offsets": [ [ 383, 400 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T22", "type": "Scope", "text": [ "deep venous insufficiency, chronic venous leg ulcer or stasis dermatitis" ], "offsets": [ [ 328, 400 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T23", "type": "Observation", "text": [ "History" ], "offsets": [ [ 317, 324 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T24", "type": "Condition", "text": [ "Breast-feeding" ], "offsets": [ [ 402, 416 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T25", "type": "Person", "text": [ "women" ], "offsets": [ [ 417, 422 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T26", "type": "Condition", "text": [ "fertile" ], "offsets": [ [ 426, 433 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T27", "type": "Person", "text": [ "women" ], "offsets": [ [ 434, 439 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T28", "type": "Observation", "text": [ "agreeing to use an effective method of contraception" ], "offsets": [ [ 444, 496 ] ], "normalized": [] }, { "id": "NCT02958072_exc_T29", "type": "Negation", "text": [ "not" ], "offsets": [ [ 440, 443 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02958072_exc_R1", "type": "Has_value", "arg1_id": "NCT02958072_exc_T1", "arg2_id": "NCT02958072_exc_T2", "normalized": [] }, { "id": "NCT02958072_exc_R2", "type": "Has_value", "arg1_id": "NCT02958072_exc_T3", "arg2_id": "NCT02958072_exc_T4", "normalized": [] }, { "id": "NCT02958072_exc_R3", "type": "AND", "arg1_id": "NCT02958072_exc_T5", "arg2_id": "NCT02958072_exc_T6", "normalized": [] }, { "id": "NCT02958072_exc_R4", "type": "Has_temporal", "arg1_id": "NCT02958072_exc_T9", "arg2_id": "NCT02958072_exc_T11", "normalized": [] }, { "id": "NCT02958072_exc_R5", "type": "Has_index", "arg1_id": "NCT02958072_exc_T9", "arg2_id": "NCT02958072_exc_T10", "normalized": [] }, { "id": "NCT02958072_exc_R6", "type": "Has_scope", "arg1_id": "NCT02958072_exc_T9", "arg2_id": "NCT02958072_exc_T14", "normalized": [] }, { "id": "NCT02958072_exc_R7", "type": "Has_temporal", "arg1_id": "NCT02958072_exc_T16", "arg2_id": "NCT02958072_exc_T18", "normalized": [] }, { "id": "NCT02958072_exc_R8", "type": "AND", "arg1_id": "NCT02958072_exc_T15", "arg2_id": "NCT02958072_exc_T16", "normalized": [] }, { "id": "NCT02958072_exc_R9", "type": "AND", "arg1_id": "NCT02958072_exc_T16", "arg2_id": "NCT02958072_exc_T17", "normalized": [] }, { "id": "NCT02958072_exc_R10", "type": "Has_temporal", "arg1_id": "NCT02958072_exc_T22", "arg2_id": "NCT02958072_exc_T23", "normalized": [] }, { "id": "NCT02958072_exc_R11", "type": "Has_negation", "arg1_id": "NCT02958072_exc_T28", "arg2_id": "NCT02958072_exc_T29", "normalized": [] }, { "id": "NCT02958072_exc_R12", "type": "AND", "arg1_id": "NCT02958072_exc_T25", "arg2_id": "NCT02958072_exc_T24", "normalized": [] }, { "id": "NCT02958072_exc_R13", "type": "AND", "arg1_id": "NCT02958072_exc_T27", "arg2_id": "NCT02958072_exc_T26", "normalized": [] } ]

[ { "id": "NCT02958072_inc_text", "type": "inclusion", "text": [ "Diabetes mellitus \nFoot ulcer at the malleoli area between 0,25 cm² and 5,0 cm² \nFoot ulcer duration more than 6 weeks \nAnkle-brachial index above 0,40 or presence of palpable pulses in arteria dorsalis pedes and/or arteria tibialis posterior \ninformed consent \n" ], "offsets": [ [ 0, 262 ] ] } ]

[ { "id": "NCT02958072_inc_T1", "type": "Condition", "text": [ "Diabetes mellitus" ], "offsets": [ [ 0, 17 ] ], "normalized": [] }, { "id": "NCT02958072_inc_T2", "type": "Condition", "text": [ "Foot ulcer" ], "offsets": [ [ 19, 29 ] ], "normalized": [] }, { "id": "NCT02958072_inc_T3", "type": "Qualifier", "text": [ "malleoli area" ], "offsets": [ [ 37, 50 ] ], "normalized": [] }, { "id": "NCT02958072_inc_T4", "type": "Value", "text": [ "between 0,25 cm² and 5,0 cm²" ], "offsets": [ [ 51, 79 ] ], "normalized": [] }, { "id": "NCT02958072_inc_T5", "type": "Condition", "text": [ "Foot ulcer" ], "offsets": [ [ 81, 91 ] ], "normalized": [] }, { "id": "NCT02958072_inc_T6", "type": "Temporal", "text": [ "more than 6 weeks" ], "offsets": [ [ 101, 118 ] ], "normalized": [] }, { "id": "NCT02958072_inc_T7", "type": "Measurement", "text": [ "Ankle-brachial index" ], "offsets": [ [ 120, 140 ] ], "normalized": [] }, { "id": "NCT02958072_inc_T8", "type": "Value", "text": [ "above 0,40" ], "offsets": [ [ 141, 151 ] ], "normalized": [] }, { "id": "NCT02958072_inc_T9", "type": "Condition", "text": [ "palpable pulses" ], "offsets": [ [ 167, 182 ] ], "normalized": [] }, { "id": "NCT02958072_inc_T10", "type": "Reference_point", "text": [ "arteria dorsalis pedes" ], "offsets": [ [ 186, 208 ] ], "normalized": [] }, { "id": "NCT02958072_inc_T11", "type": "Reference_point", "text": [ "arteria tibialis posterior" ], "offsets": [ [ 216, 242 ] ], "normalized": [] }, { "id": "NCT02958072_inc_T12", "type": "Scope", "text": [ "arteria dorsalis pedes and/or arteria tibialis posterior" ], "offsets": [ [ 186, 242 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02958072_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT02958072_inc_T2", "arg2_id": "NCT02958072_inc_T3", "normalized": [] }, { "id": "NCT02958072_inc_R2", "type": "Has_value", "arg1_id": "NCT02958072_inc_T2", "arg2_id": "NCT02958072_inc_T4", "normalized": [] }, { "id": "NCT02958072_inc_R3", "type": "Has_temporal", "arg1_id": "NCT02958072_inc_T5", "arg2_id": "NCT02958072_inc_T6", "normalized": [] }, { "id": "NCT02958072_inc_R4", "type": "Has_value", "arg1_id": "NCT02958072_inc_T7", "arg2_id": "NCT02958072_inc_T8", "normalized": [] }, { "id": "NCT02958072_inc_R5", "type": "Has_scope", "arg1_id": "NCT02958072_inc_T9", "arg2_id": "NCT02958072_inc_T12", "normalized": [] } ]

[ { "id": "NCT02958566_exc_text", "type": "exclusion", "text": [ "History of constipation\nPre-existing use of narcotics or opioids\nPre-existing renal or hepatic failure\nMental illness, mental retardation, or inability to participate in informed consent due to mental status\nPre-existing dementia\nAllergy to any protocol medication\nEmergency operation\nSubjects who are incarcerated or wards of the state\nMinors\nSubjects with inflammatory bowel disease, active colitis, or pre-existing intra-abdominal inflammation. Diverticulitis without active infection/inflammation will not be excluded.\n" ], "offsets": [ [ 0, 523 ] ] } ]

[ { "id": "NCT02958566_exc_T1", "type": "Condition", "text": [ "constipation" ], "offsets": [ [ 11, 23 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T2", "type": "Drug", "text": [ "narcotics" ], "offsets": [ [ 44, 53 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T3", "type": "Drug", "text": [ "opioids" ], "offsets": [ [ 57, 64 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T4", "type": "Temporal", "text": [ "Pre-existing" ], "offsets": [ [ 24, 36 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T5", "type": "Scope", "text": [ "narcotics or opioids" ], "offsets": [ [ 44, 64 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T6", "type": "Condition", "text": [ "hepatic failure" ], "offsets": [ [ 87, 102 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T7", "type": "Temporal", "text": [ "Pre-existing" ], "offsets": [ [ 65, 77 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T8", "type": "Condition", "text": [ "nal o", "ilure\nM" ], "offsets": [ [ 80, 85 ], [ 97, 104 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T9", "type": "Scope", "text": [ "renal or hepatic failure" ], "offsets": [ [ 78, 102 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T10", "type": "Condition", "text": [ "Mental illness" ], "offsets": [ [ 103, 117 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T11", "type": "Condition", "text": [ "mental retardation" ], "offsets": [ [ 119, 137 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T12", "type": "Condition", "text": [ "inability to participate in informed consent" ], "offsets": [ [ 142, 186 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T13", "type": "Condition", "text": [ "mental status" ], "offsets": [ [ 194, 207 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T14", "type": "Condition", "text": [ "dementia" ], "offsets": [ [ 221, 229 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T15", "type": "Temporal", "text": [ "Pre-existing" ], "offsets": [ [ 208, 220 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T16", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 230, 237 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T17", "type": "Procedure", "text": [ "operation" ], "offsets": [ [ 275, 284 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T18", "type": "Qualifier", "text": [ "Emergency" ], "offsets": [ [ 265, 274 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T20", "type": "Person", "text": [ "Minors" ], "offsets": [ [ 337, 343 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T21", "type": "Condition", "text": [ "inflammatory bowel disease" ], "offsets": [ [ 358, 384 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T22", "type": "Condition", "text": [ "colitis" ], "offsets": [ [ 393, 400 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T23", "type": "Temporal", "text": [ "active" ], "offsets": [ [ 386, 392 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T24", "type": "Condition", "text": [ "intra-abdominal inflammation" ], "offsets": [ [ 418, 446 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T25", "type": "Temporal", "text": [ "pre-existing" ], "offsets": [ [ 405, 417 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T26", "type": "Condition", "text": [ "Diverticulitis" ], "offsets": [ [ 448, 462 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T27", "type": "Temporal", "text": [ "active" ], "offsets": [ [ 471, 477 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T28", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 478, 487 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T29", "type": "Condition", "text": [ "inflammation" ], "offsets": [ [ 488, 500 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T30", "type": "Negation", "text": [ "not be excluded" ], "offsets": [ [ 506, 521 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T31", "type": "Scope", "text": [ "infection/inflammation" ], "offsets": [ [ 478, 500 ] ], "normalized": [] }, { "id": "NCT02958566_exc_T32", "type": "Negation", "text": [ "without" ], "offsets": [ [ 463, 470 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02958566_exc_R1", "type": "Has_temporal", "arg1_id": "NCT02958566_exc_T5", "arg2_id": "NCT02958566_exc_T4", "normalized": [] }, { "id": "NCT02958566_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02958566_exc_T9", "arg2_id": "NCT02958566_exc_T7", "normalized": [] }, { "id": "NCT02958566_exc_R3", "type": "AND", "arg1_id": "NCT02958566_exc_T12", "arg2_id": "NCT02958566_exc_T13", "normalized": [] }, { "id": "NCT02958566_exc_R4", "type": "Has_temporal", "arg1_id": "NCT02958566_exc_T14", "arg2_id": "NCT02958566_exc_T15", "normalized": [] }, { "id": "NCT02958566_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02958566_exc_T17", "arg2_id": "NCT02958566_exc_T18", "normalized": [] }, { "id": "NCT02958566_exc_R6", "type": "Has_temporal", "arg1_id": "NCT02958566_exc_T22", "arg2_id": "NCT02958566_exc_T23", "normalized": [] }, { "id": "NCT02958566_exc_R7", "type": "Has_temporal", "arg1_id": "NCT02958566_exc_T24", "arg2_id": "NCT02958566_exc_T25", "normalized": [] }, { "id": "NCT02958566_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02958566_exc_T31", "arg2_id": "NCT02958566_exc_T27", "normalized": [] }, { "id": "NCT02958566_exc_R9", "type": "Has_scope", "arg1_id": "NCT02958566_exc_T26", "arg2_id": "NCT02958566_exc_T31", "normalized": [] }, { "id": "NCT02958566_exc_R10", "type": "Has_negation", "arg1_id": "NCT02958566_exc_T31", "arg2_id": "NCT02958566_exc_T32", "normalized": [] }, { "id": "NCT02958566_exc_R11", "type": "Has_negation", "arg1_id": "NCT02958566_exc_T26", "arg2_id": "NCT02958566_exc_T30", "normalized": [] } ]

[ { "id": "NCT02958566_inc_text", "type": "inclusion", "text": [ "Males or females above the age of 18\nPatients undergoing laparoscopic or robotic colorectal resections\n" ], "offsets": [ [ 0, 103 ] ] } ]

[ { "id": "NCT02958566_inc_T1", "type": "Person", "text": [ "Males" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT02958566_inc_T2", "type": "Person", "text": [ "females" ], "offsets": [ [ 9, 16 ] ], "normalized": [] }, { "id": "NCT02958566_inc_T3", "type": "Value", "text": [ "above the age of 18" ], "offsets": [ [ 17, 36 ] ], "normalized": [] }, { "id": "NCT02958566_inc_T4", "type": "Person", "text": [ "age" ], "offsets": [ [ 27, 30 ] ], "normalized": [] }, { "id": "NCT02958566_inc_T5", "type": "Qualifier", "text": [ "laparoscopic" ], "offsets": [ [ 57, 69 ] ], "normalized": [] }, { "id": "NCT02958566_inc_T6", "type": "Qualifier", "text": [ "robotic" ], "offsets": [ [ 73, 80 ] ], "normalized": [] }, { "id": "NCT02958566_inc_T7", "type": "Procedure", "text": [ "colorectal resections" ], "offsets": [ [ 81, 102 ] ], "normalized": [] }, { "id": "NCT02958566_inc_T8", "type": "Scope", "text": [ "laparoscopic or robotic" ], "offsets": [ [ 57, 80 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02958566_inc_R1", "type": "Has_value", "arg1_id": "NCT02958566_inc_T4", "arg2_id": "NCT02958566_inc_T3", "normalized": [] }, { "id": "NCT02958566_inc_R2", "type": "Has_scope", "arg1_id": "NCT02958566_inc_T7", "arg2_id": "NCT02958566_inc_T8", "normalized": [] } ]

[ { "id": "NCT02959580_exc_text", "type": "exclusion", "text": [ "Breast Carcinoma\n" ], "offsets": [ [ 0, 17 ] ] } ]

[ { "id": "NCT02959580_exc_T1", "type": "Condition", "text": [ "Breast Carcinoma" ], "offsets": [ [ 0, 16 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "NCT02959580_inc_text", "type": "inclusion", "text": [ "Idiopathic Granulomatous Mastitis\n" ], "offsets": [ [ 0, 34 ] ] } ]

[ { "id": "NCT02959580_inc_T1", "type": "Condition", "text": [ "Idiopathic Granulomatous Mastitis" ], "offsets": [ [ 0, 33 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "NCT02959801_exc_text", "type": "exclusion", "text": [ "presence of subacute or chronic DVT more than 21 days in duration, inability to lie in the prone position required for intervention, terminal systemic disease requiring palliative treatment, active bleeding (from a gastric/duodenal ulcer or the cerebrovascular system), a haemorrhagic stroke within the previous year, an impaired bleeding-clotting profile, and any haemophilic disorder, or pregnancy.\n" ], "offsets": [ [ 0, 401 ] ] } ]

[ { "id": "NCT02959801_exc_T1", "type": "Qualifier", "text": [ "subacute" ], "offsets": [ [ 12, 20 ] ], "normalized": [] }, { "id": "NCT02959801_exc_T2", "type": "Qualifier", "text": [ "chronic" ], "offsets": [ [ 24, 31 ] ], "normalized": [] }, { "id": "NCT02959801_exc_T3", "type": "Condition", "text": [ "DVT" ], "offsets": [ [ 32, 35 ] ], "normalized": [] }, { "id": "NCT02959801_exc_T4", "type": "Scope", "text": [ "subacute or chronic" ], "offsets": [ [ 12, 31 ] ], "normalized": [] }, { "id": "NCT02959801_exc_T5", "type": "Multiplier", "text": [ "more than 21 days in duration" ], "offsets": [ [ 36, 65 ] ], "normalized": [] }, { "id": "NCT02959801_exc_T6", "type": "Condition", "text": [ "inability to lie in the prone position" ], "offsets": [ [ 67, 105 ] ], "normalized": [] }, { "id": "NCT02959801_exc_T8", "type": "Condition", "text": [ "terminal systemic disease" ], "offsets": [ [ 133, 158 ] ], "normalized": [] }, { "id": "NCT02959801_exc_T9", "type": "Procedure", "text": [ "palliative treatment" ], "offsets": [ [ 169, 189 ] ], "normalized": [] }, { "id": "NCT02959801_exc_T10", "type": "Mood", "text": [ "requiring" ], "offsets": [ [ 159, 168 ] ], "normalized": [] }, { "id": "NCT02959801_exc_T11", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 191, 197 ] ], "normalized": [] }, { "id": "NCT02959801_exc_T12", "type": "Condition", "text": [ "bleeding" ], "offsets": [ [ 198, 206 ] ], "normalized": [] }, { "id": "NCT02959801_exc_T13", "type": "Condition", "text": [ "duodenal ulcer" ], "offsets": [ [ 223, 237 ] ], "normalized": [] }, { "id": "NCT02959801_exc_T14", "type": "Condition", "text": [ "gastric", "ulcer" ], "offsets": [ [ 215, 222 ], [ 232, 237 ] ], "normalized": [] }, { "id": "NCT02959801_exc_T15", "type": "Qualifier", "text": [ "cerebrovascular system" ], "offsets": [ [ 245, 267 ] ], "normalized": [] }, { "id": "NCT02959801_exc_T16", "type": "Scope", "text": [ "gastric/duodenal ulcer or the cerebrovascular system" ], "offsets": [ [ 215, 267 ] ], "normalized": [] }, { "id": "NCT02959801_exc_T17", "type": "Condition", "text": [ "haemorrhagic stroke" ], "offsets": [ [ 272, 291 ] ], "normalized": [] }, { "id": "NCT02959801_exc_T18", "type": "Temporal", "text": [ "within the previous year" ], "offsets": [ [ 292, 316 ] ], "normalized": [] }, { "id": "NCT02959801_exc_T19", "type": "Condition", "text": [ "impaired bleeding-clotting profile" ], "offsets": [ [ 321, 355 ] ], "normalized": [] }, { "id": "NCT02959801_exc_T20", "type": "Condition", "text": [ "haemophilic disorder" ], "offsets": [ [ 365, 385 ] ], "normalized": [] }, { "id": "NCT02959801_exc_T21", "type": "Condition", "text": [ "pregnancy" ], "offsets": [ [ 390, 399 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02959801_exc_R1", "type": "Has_scope", "arg1_id": "NCT02959801_exc_T3", "arg2_id": "NCT02959801_exc_T4", "normalized": [] }, { "id": "NCT02959801_exc_R2", "type": "Has_multiplier", "arg1_id": "NCT02959801_exc_T3", "arg2_id": "NCT02959801_exc_T5", "normalized": [] }, { "id": "NCT02959801_exc_R3", "type": "Has_mood", "arg1_id": "NCT02959801_exc_T9", "arg2_id": "NCT02959801_exc_T10", "normalized": [] }, { "id": "NCT02959801_exc_R4", "type": "AND", "arg1_id": "NCT02959801_exc_T8", "arg2_id": "NCT02959801_exc_T9", "normalized": [] }, { "id": "NCT02959801_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02959801_exc_T12", "arg2_id": "NCT02959801_exc_T11", "normalized": [] }, { "id": "NCT02959801_exc_R6", "type": "Has_scope", "arg1_id": "NCT02959801_exc_T12", "arg2_id": "NCT02959801_exc_T16", "normalized": [] }, { "id": "NCT02959801_exc_R7", "type": "Has_temporal", "arg1_id": "NCT02959801_exc_T17", "arg2_id": "NCT02959801_exc_T18", "normalized": [] } ]

[ { "id": "NCT02959801_inc_text", "type": "inclusion", "text": [ "proven acute deep venous thrombosis, less than 21 days and who were referred to the interventional radiology department.\n" ], "offsets": [ [ 0, 121 ] ] } ]

[ { "id": "NCT02959801_inc_T1", "type": "Qualifier", "text": [ "acute" ], "offsets": [ [ 7, 12 ] ], "normalized": [] }, { "id": "NCT02959801_inc_T2", "type": "Condition", "text": [ "deep venous thrombosis" ], "offsets": [ [ 13, 35 ] ], "normalized": [] }, { "id": "NCT02959801_inc_T3", "type": "Qualifier", "text": [ "proven" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "NCT02959801_inc_T4", "type": "Multiplier", "text": [ "less than 21 days" ], "offsets": [ [ 37, 54 ] ], "normalized": [] }, { "id": "NCT02959801_inc_T5", "type": "Visit", "text": [ "interventional radiology department" ], "offsets": [ [ 84, 119 ] ], "normalized": [] }, { "id": "NCT02959801_inc_T6", "type": "Mood", "text": [ "referred to" ], "offsets": [ [ 68, 79 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02959801_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT02959801_inc_T2", "arg2_id": "NCT02959801_inc_T1", "normalized": [] }, { "id": "NCT02959801_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02959801_inc_T2", "arg2_id": "NCT02959801_inc_T3", "normalized": [] }, { "id": "NCT02959801_inc_R3", "type": "Has_multiplier", "arg1_id": "NCT02959801_inc_T2", "arg2_id": "NCT02959801_inc_T4", "normalized": [] }, { "id": "NCT02959801_inc_R4", "type": "Has_mood", "arg1_id": "NCT02959801_inc_T5", "arg2_id": "NCT02959801_inc_T6", "normalized": [] } ]

[ { "id": "NCT02961582_exc_text", "type": "exclusion", "text": [ "Obstructed outlet syndrome (objectified by defeacography)\nIrritable bowel syndrome (Rome-IV criteria for irritable bowel syndrome)\nCongenital or organic bowel pathology\nRectal prolapse\nAnatomical limitations preventing placement of an electrode\nSkin and perineal disease with risk of infection\nPrevious large bowel/rectal surgery\nStoma\nCoexisting neurological disease\nSignificant psychological co-morbidity as assessed subjectively by the investigator\nBeing or attempting to become pregnant during study follow-up\n" ], "offsets": [ [ 0, 514 ] ] } ]

[ { "id": "NCT02961582_exc_T1", "type": "Condition", "text": [ "Obstructed outlet syndrome" ], "offsets": [ [ 0, 26 ] ], "normalized": [] }, { "id": "NCT02961582_exc_T2", "type": "Procedure", "text": [ "defeacography" ], "offsets": [ [ 43, 56 ] ], "normalized": [] }, { "id": "NCT02961582_exc_T3", "type": "Condition", "text": [ "Irritable bowel syndrome" ], "offsets": [ [ 58, 82 ] ], "normalized": [] }, { "id": "NCT02961582_exc_T4", "type": "Measurement", "text": [ "Rome-IV criteria" ], "offsets": [ [ 84, 100 ] ], "normalized": [] }, { "id": "NCT02961582_exc_T5", "type": "Condition", "text": [ "irritable bowel syndrome" ], "offsets": [ [ 105, 129 ] ], "normalized": [] }, { "id": "NCT02961582_exc_T6", "type": "Condition", "text": [ "organic bowel pathology" ], "offsets": [ [ 145, 168 ] ], "normalized": [] }, { "id": "NCT02961582_exc_T7", "type": "Condition", "text": [ "ngenital o", "wel pathology\nR" ], "offsets": [ [ 133, 143 ], [ 155, 170 ] ], "normalized": [] }, { "id": "NCT02961582_exc_T8", "type": "Condition", "text": [ "Rectal prolapse" ], "offsets": [ [ 169, 184 ] ], "normalized": [] }, { "id": "NCT02961582_exc_T9", "type": "Observation", "text": [ "Anatomical limitations" ], "offsets": [ [ 185, 207 ] ], "normalized": [] }, { "id": "NCT02961582_exc_T10", "type": "Procedure", "text": [ "placement of an electrode" ], "offsets": [ [ 219, 244 ] ], "normalized": [] }, { "id": "NCT02961582_exc_T11", "type": "Negation", "text": [ "preventing" ], "offsets": [ [ 208, 218 ] ], "normalized": [] }, { "id": "NCT02961582_exc_T13", "type": "Condition", "text": [ "perineal disease" ], "offsets": [ [ 254, 270 ] ], "normalized": [] }, { "id": "NCT02961582_exc_T14", "type": "Condition", "text": [ "and", "se with" ], "offsets": [ [ 250, 253 ], [ 268, 275 ] ], "normalized": [] }, { "id": "NCT02961582_exc_T15", "type": "Observation", "text": [ "risk of infection" ], "offsets": [ [ 276, 293 ] ], "normalized": [] }, { "id": "NCT02961582_exc_T17", "type": "Procedure", "text": [ "rectal surgery" ], "offsets": [ [ 315, 329 ] ], "normalized": [] }, { "id": "NCT02961582_exc_T18", "type": "Procedure", "text": [ "bowel/recta", "y\nStoma" ], "offsets": [ [ 309, 320 ], [ 328, 335 ] ], "normalized": [] }, { "id": "NCT02961582_exc_T20", "type": "Condition", "text": [ "Stoma" ], "offsets": [ [ 330, 335 ] ], "normalized": [] }, { "id": "NCT02961582_exc_T21", "type": "Condition", "text": [ "neurological disease" ], "offsets": [ [ 347, 367 ] ], "normalized": [] }, { "id": "NCT02961582_exc_T22", "type": "Condition", "text": [ "psychological co-morbidity" ], "offsets": [ [ 380, 406 ] ], "normalized": [] }, { "id": "NCT02961582_exc_T23", "type": "Qualifier", "text": [ "Significant" ], "offsets": [ [ 368, 379 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02961582_exc_R1", "type": "AND", "arg1_id": "NCT02961582_exc_T2", "arg2_id": "NCT02961582_exc_T1", "normalized": [] }, { "id": "NCT02961582_exc_R2", "type": "AND", "arg1_id": "NCT02961582_exc_T4", "arg2_id": "NCT02961582_exc_T5", "normalized": [] }, { "id": "NCT02961582_exc_R3", "type": "Has_negation", "arg1_id": "NCT02961582_exc_T10", "arg2_id": "NCT02961582_exc_T11", "normalized": [] }, { "id": "NCT02961582_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT02961582_exc_T22", "arg2_id": "NCT02961582_exc_T23", "normalized": [] } ]

[ { "id": "NCT02961582_inc_text", "type": "inclusion", "text": [ "An average defecation frequency (DF) of <3 per week based on a 3-week defecation diary (patient-reported)\nMeet at least one other criterion of the Rome-IV criteria for idiopathic constipation based on the 3-week defecation diary (1)\nRefractory to conservative treatment\nAge: 14-80 years\nStraining during =25% of defecations\nLumpy or hard stools in =25% of defecations\nSensation of incomplete evacuation for =25% of defecations\nSensation of anorectal obstruction/blockage for =25% of defecations\nManual manoeuvres to facilitate =25% of defecations\n" ], "offsets": [ [ 0, 547 ] ] } ]

[ { "id": "NCT02961582_inc_T1", "type": "Measurement", "text": [ "average defecation frequency" ], "offsets": [ [ 3, 31 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T2", "type": "Measurement", "text": [ "DF" ], "offsets": [ [ 33, 35 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T3", "type": "Value", "text": [ "<3 per week" ], "offsets": [ [ 40, 51 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T4", "type": "Procedure", "text": [ "3-week defecation diary" ], "offsets": [ [ 63, 86 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T7", "type": "Multiplier", "text": [ "at least one" ], "offsets": [ [ 111, 123 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T8", "type": "Measurement", "text": [ "Rome-IV criteria for idiopathic constipation" ], "offsets": [ [ 147, 191 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T9", "type": "Condition", "text": [ "idiopathic constipation" ], "offsets": [ [ 168, 191 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T10", "type": "Procedure", "text": [ "3-week defecation diary" ], "offsets": [ [ 205, 228 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T13", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 124, 129 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T14", "type": "Procedure", "text": [ "conservative treatment" ], "offsets": [ [ 247, 269 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T15", "type": "Qualifier", "text": [ "Refractory" ], "offsets": [ [ 233, 243 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T16", "type": "Person", "text": [ "Age" ], "offsets": [ [ 270, 273 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T17", "type": "Value", "text": [ "14-80 years" ], "offsets": [ [ 275, 286 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T18", "type": "Condition", "text": [ "Straining" ], "offsets": [ [ 287, 296 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T21", "type": "Multiplier", "text": [ "=25%" ], "offsets": [ [ 304, 308 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T22", "type": "Condition", "text": [ "defecations" ], "offsets": [ [ 312, 323 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T23", "type": "Observation", "text": [ "hard stools" ], "offsets": [ [ 333, 344 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T24", "type": "Observation", "text": [ " or ", "s in =" ], "offsets": [ [ 329, 333 ], [ 343, 349 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T25", "type": "Condition", "text": [ "defecations" ], "offsets": [ [ 356, 367 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T26", "type": "Multiplier", "text": [ "=25%" ], "offsets": [ [ 348, 352 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T29", "type": "Condition", "text": [ "Sensation of incomplete evacuation" ], "offsets": [ [ 368, 402 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T30", "type": "Multiplier", "text": [ "=25%" ], "offsets": [ [ 407, 411 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T31", "type": "Condition", "text": [ "defecations" ], "offsets": [ [ 415, 426 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T27", "type": "Condition", "text": [ "defecations" ], "offsets": [ [ 483, 494 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T28", "type": "Multiplier", "text": [ "=25%" ], "offsets": [ [ 475, 479 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T32", "type": "Condition", "text": [ "Sensation of anorectal obstruction" ], "offsets": [ [ 427, 461 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T33", "type": "Condition", "text": [ "on of anorectal obstru", "e for =2" ], "offsets": [ [ 434, 456 ], [ 469, 477 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T35", "type": "Condition", "text": [ "defecations" ], "offsets": [ [ 535, 546 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T36", "type": "Multiplier", "text": [ "=25%" ], "offsets": [ [ 527, 531 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T37", "type": "Procedure", "text": [ "Manual manoeuvres" ], "offsets": [ [ 495, 512 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T11", "type": "Condition", "text": [ "criterion" ], "offsets": [ [ 130, 139 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T12", "type": "Scope", "text": [ "Sensation of anorectal obstruction/blockage" ], "offsets": [ [ 427, 470 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T34", "type": "Scope", "text": [ "Lumpy or hard stools" ], "offsets": [ [ 324, 344 ] ], "normalized": [] }, { "id": "NCT02961582_inc_T5", "type": "Qualifier", "text": [ "patient-reported" ], "offsets": [ [ 88, 104 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02961582_inc_R1", "type": "Subsumes", "arg1_id": "NCT02961582_inc_T1", "arg2_id": "NCT02961582_inc_T2", "normalized": [] }, { "id": "NCT02961582_inc_R2", "type": "Has_value", "arg1_id": "NCT02961582_inc_T1", "arg2_id": "NCT02961582_inc_T3", "normalized": [] }, { "id": "NCT02961582_inc_R3", "type": "AND", "arg1_id": "NCT02961582_inc_T1", "arg2_id": "NCT02961582_inc_T4", "normalized": [] }, { "id": "NCT02961582_inc_R12", "type": "Has_qualifier", "arg1_id": "NCT02961582_inc_T14", "arg2_id": "NCT02961582_inc_T15", "normalized": [] }, { "id": "NCT02961582_inc_R13", "type": "Has_value", "arg1_id": "NCT02961582_inc_T16", "arg2_id": "NCT02961582_inc_T17", "normalized": [] }, { "id": "NCT02961582_inc_R19", "type": "Has_multiplier", "arg1_id": "NCT02961582_inc_T25", "arg2_id": "NCT02961582_inc_T26", "normalized": [] }, { "id": "NCT02961582_inc_R21", "type": "Has_multiplier", "arg1_id": "NCT02961582_inc_T31", "arg2_id": "NCT02961582_inc_T30", "normalized": [] }, { "id": "NCT02961582_inc_R20", "type": "Has_multiplier", "arg1_id": "NCT02961582_inc_T27", "arg2_id": "NCT02961582_inc_T28", "normalized": [] }, { "id": "NCT02961582_inc_R22", "type": "Has_multiplier", "arg1_id": "NCT02961582_inc_T35", "arg2_id": "NCT02961582_inc_T36", "normalized": [] }, { "id": "NCT02961582_inc_R8", "type": "AND", "arg1_id": "NCT02961582_inc_T11", "arg2_id": "NCT02961582_inc_T8", "normalized": [] }, { "id": "NCT02961582_inc_R10", "type": "Has_qualifier", "arg1_id": "NCT02961582_inc_T11", "arg2_id": "NCT02961582_inc_T13", "normalized": [] }, { "id": "NCT02961582_inc_R9", "type": "Has_multiplier", "arg1_id": "NCT02961582_inc_T11", "arg2_id": "NCT02961582_inc_T7", "normalized": [] }, { "id": "NCT02961582_inc_R6", "type": "AND", "arg1_id": "NCT02961582_inc_T8", "arg2_id": "NCT02961582_inc_T10", "normalized": [] }, { "id": "NCT02961582_inc_R4", "type": "AND", "arg1_id": "NCT02961582_inc_T29", "arg2_id": "NCT02961582_inc_T31", "normalized": [] }, { "id": "NCT02961582_inc_R11", "type": "AND", "arg1_id": "NCT02961582_inc_T12", "arg2_id": "NCT02961582_inc_T27", "normalized": [] }, { "id": "NCT02961582_inc_R23", "type": "AND", "arg1_id": "NCT02961582_inc_T37", "arg2_id": "NCT02961582_inc_T35", "normalized": [] }, { "id": "NCT02961582_inc_R24", "type": "AND", "arg1_id": "NCT02961582_inc_T34", "arg2_id": "NCT02961582_inc_T25", "normalized": [] }, { "id": "NCT02961582_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT02961582_inc_T4", "arg2_id": "NCT02961582_inc_T5", "normalized": [] }, { "id": "NCT02961582_inc_R14", "type": "AND", "arg1_id": "NCT02961582_inc_T18", "arg2_id": "NCT02961582_inc_T22", "normalized": [] }, { "id": "NCT02961582_inc_R15", "type": "Has_multiplier", "arg1_id": "NCT02961582_inc_T22", "arg2_id": "NCT02961582_inc_T21", "normalized": [] } ]

[ { "id": "NCT02961764_exc_text", "type": "exclusion", "text": [ "Known or suspected gram-negative infections, anaerobic infections, or fungemia\nKnown or suspected infections that are severe, life threatening or are not included in the ABSSSI Food and Drug Administration (FDA) guidance\nInjection drug users with a fever\nSevere neurological disorder leading to immobility or confined to a wheelchair\nBilateral Lower extremity involvement of the suspected infection.\n" ], "offsets": [ [ 0, 400 ] ] } ]

[ { "id": "NCT02961764_exc_T1", "type": "Qualifier", "text": [ "gram-negative" ], "offsets": [ [ 19, 32 ] ], "normalized": [] }, { "id": "NCT02961764_exc_T2", "type": "Condition", "text": [ "infections" ], "offsets": [ [ 33, 43 ] ], "normalized": [] }, { "id": "NCT02961764_exc_T3", "type": "Condition", "text": [ "infections" ], "offsets": [ [ 55, 65 ] ], "normalized": [] }, { "id": "NCT02961764_exc_T4", "type": "Qualifier", "text": [ "anaerobic" ], "offsets": [ [ 45, 54 ] ], "normalized": [] }, { "id": "NCT02961764_exc_T5", "type": "Condition", "text": [ "fungemia" ], "offsets": [ [ 70, 78 ] ], "normalized": [] }, { "id": "NCT02961764_exc_T6", "type": "Condition", "text": [ "infections" ], "offsets": [ [ 98, 108 ] ], "normalized": [] }, { "id": "NCT02961764_exc_T7", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 118, 124 ] ], "normalized": [] }, { "id": "NCT02961764_exc_T8", "type": "Qualifier", "text": [ "life threatening" ], "offsets": [ [ 126, 142 ] ], "normalized": [] }, { "id": "NCT02961764_exc_T9", "type": "Person", "text": [ "drug users" ], "offsets": [ [ 231, 241 ] ], "normalized": [] }, { "id": "NCT02961764_exc_T10", "type": "Condition", "text": [ "fever" ], "offsets": [ [ 249, 254 ] ], "normalized": [] }, { "id": "NCT02961764_exc_T11", "type": "Condition", "text": [ "neurological disorder" ], "offsets": [ [ 262, 283 ] ], "normalized": [] }, { "id": "NCT02961764_exc_T12", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 255, 261 ] ], "normalized": [] }, { "id": "NCT02961764_exc_T13", "type": "Observation", "text": [ "immobility" ], "offsets": [ [ 295, 305 ] ], "normalized": [] }, { "id": "NCT02961764_exc_T14", "type": "Device", "text": [ "wheelchair" ], "offsets": [ [ 323, 333 ] ], "normalized": [] }, { "id": "NCT02961764_exc_T15", "type": "Scope", "text": [ "immobility or confined to a wheelchair" ], "offsets": [ [ 295, 333 ] ], "normalized": [] }, { "id": "NCT02961764_exc_T16", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 389, 398 ] ], "normalized": [] }, { "id": "NCT02961764_exc_T17", "type": "Qualifier", "text": [ "Bilateral Lower extremity" ], "offsets": [ [ 334, 359 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02961764_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02961764_exc_T2", "arg2_id": "NCT02961764_exc_T1", "normalized": [] }, { "id": "NCT02961764_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02961764_exc_T3", "arg2_id": "NCT02961764_exc_T4", "normalized": [] }, { "id": "NCT02961764_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02961764_exc_T6", "arg2_id": "NCT02961764_exc_T7", "normalized": [] }, { "id": "NCT02961764_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT02961764_exc_T6", "arg2_id": "NCT02961764_exc_T8", "normalized": [] }, { "id": "NCT02961764_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02961764_exc_T11", "arg2_id": "NCT02961764_exc_T12", "normalized": [] }, { "id": "NCT02961764_exc_R6", "type": "AND", "arg1_id": "NCT02961764_exc_T15", "arg2_id": "NCT02961764_exc_T11", "normalized": [] }, { "id": "NCT02961764_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT02961764_exc_T16", "arg2_id": "NCT02961764_exc_T17", "normalized": [] } ]

[ { "id": "NCT02961764_inc_text", "type": "inclusion", "text": [ "Presents to the Emergency Department (ED) and meets the clinical definition for Acute Bacterial Skin and Skin Structure Infections (ABSSSI)\nKnown or suspected gram-positive infection.\n" ], "offsets": [ [ 0, 184 ] ] } ]

[ { "id": "NCT02961764_inc_T1", "type": "Visit", "text": [ "Emergency Department (ED)" ], "offsets": [ [ 16, 41 ] ], "normalized": [] }, { "id": "NCT02961764_inc_T2", "type": "Measurement", "text": [ "Acute Bacterial Skin and Skin Structure Infections" ], "offsets": [ [ 80, 130 ] ], "normalized": [] }, { "id": "NCT02961764_inc_T3", "type": "Measurement", "text": [ "ABSSSI" ], "offsets": [ [ 132, 138 ] ], "normalized": [] }, { "id": "NCT02961764_inc_T4", "type": "Qualifier", "text": [ "gram-positive" ], "offsets": [ [ 159, 172 ] ], "normalized": [] }, { "id": "NCT02961764_inc_T5", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 173, 182 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02961764_inc_R1", "type": "Subsumes", "arg1_id": "NCT02961764_inc_T2", "arg2_id": "NCT02961764_inc_T3", "normalized": [] }, { "id": "NCT02961764_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02961764_inc_T5", "arg2_id": "NCT02961764_inc_T4", "normalized": [] } ]

[ { "id": "NCT02964416_exc_text", "type": "exclusion", "text": [ "Patients with a history of allergy or hypersensitivity to tramadol.\nHistory of epilepsy or convulsions due to any reason.\nChronic usage of analgesic drugs.\nPatients using monoamine oxidase inhibitors.\nPatients with clinical signs of raised ICP.\nObesity (women with a body mass index >35 kg/m2 or men with a body mass index >42 kg/m2)\nLanguage barrier.\nPatients taking B-blockers or Ca channel blockers.\nPatients above 65 years of age ( Physiology difference)\n" ], "offsets": [ [ 0, 459 ] ] } ]

[ { "id": "NCT02964416_exc_T1", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 27, 34 ] ], "normalized": [] }, { "id": "NCT02964416_exc_T2", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 38, 54 ] ], "normalized": [] }, { "id": "NCT02964416_exc_T3", "type": "Drug", "text": [ "tramadol" ], "offsets": [ [ 58, 66 ] ], "normalized": [] }, { "id": "NCT02964416_exc_T4", "type": "Scope", "text": [ "allergy or hypersensitivity" ], "offsets": [ [ 27, 54 ] ], "normalized": [] }, { "id": "NCT02964416_exc_T5", "type": "Condition", "text": [ "epilepsy" ], "offsets": [ [ 79, 87 ] ], "normalized": [] }, { "id": "NCT02964416_exc_T6", "type": "Condition", "text": [ "convulsions" ], "offsets": [ [ 91, 102 ] ], "normalized": [] }, { "id": "NCT02964416_exc_T7", "type": "Drug", "text": [ "analgesic drugs" ], "offsets": [ [ 139, 154 ] ], "normalized": [] }, { "id": "NCT02964416_exc_T8", "type": "Drug", "text": [ "monoamine oxidase inhibitors" ], "offsets": [ [ 171, 199 ] ], "normalized": [] }, { "id": "NCT02964416_exc_T9", "type": "Measurement", "text": [ "ICP" ], "offsets": [ [ 240, 243 ] ], "normalized": [] }, { "id": "NCT02964416_exc_T10", "type": "Value", "text": [ "raised" ], "offsets": [ [ 233, 239 ] ], "normalized": [] }, { "id": "NCT02964416_exc_T11", "type": "Condition", "text": [ "Obesity" ], "offsets": [ [ 245, 252 ] ], "normalized": [] }, { "id": "NCT02964416_exc_T12", "type": "Person", "text": [ "women" ], "offsets": [ [ 254, 259 ] ], "normalized": [] }, { "id": "NCT02964416_exc_T13", "type": "Measurement", "text": [ "body mass index" ], "offsets": [ [ 267, 282 ] ], "normalized": [] }, { "id": "NCT02964416_exc_T14", "type": "Value", "text": [ ">35 kg/m2" ], "offsets": [ [ 283, 292 ] ], "normalized": [] }, { "id": "NCT02964416_exc_T15", "type": "Person", "text": [ "men" ], "offsets": [ [ 296, 299 ] ], "normalized": [] }, { "id": "NCT02964416_exc_T16", "type": "Measurement", "text": [ "body mass index" ], "offsets": [ [ 307, 322 ] ], "normalized": [] }, { "id": "NCT02964416_exc_T17", "type": "Value", "text": [ ">42 kg/m2" ], "offsets": [ [ 323, 332 ] ], "normalized": [] }, { "id": "NCT02964416_exc_T18", "type": "Scope", "text": [ "women with a body mass index >35 kg/m2 or men with a body mass index >42 kg/m2" ], "offsets": [ [ 254, 332 ] ], "normalized": [] }, { "id": "NCT02964416_exc_T20", "type": "Drug", "text": [ "Ca channel blockers" ], "offsets": [ [ 382, 401 ] ], "normalized": [] }, { "id": "NCT02964416_exc_T21", "type": "Drug", "text": [ "B-blockers" ], "offsets": [ [ 368, 378 ] ], "normalized": [] }, { "id": "NCT02964416_exc_T22", "type": "Person", "text": [ "age" ], "offsets": [ [ 430, 433 ] ], "normalized": [] }, { "id": "NCT02964416_exc_T23", "type": "Value", "text": [ "above 65 years" ], "offsets": [ [ 412, 426 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02964416_exc_R1", "type": "AND", "arg1_id": "NCT02964416_exc_T4", "arg2_id": "NCT02964416_exc_T3", "normalized": [] }, { "id": "NCT02964416_exc_R2", "type": "Has_value", "arg1_id": "NCT02964416_exc_T9", "arg2_id": "NCT02964416_exc_T10", "normalized": [] }, { "id": "NCT02964416_exc_R3", "type": "AND", "arg1_id": "NCT02964416_exc_T13", "arg2_id": "NCT02964416_exc_T12", "normalized": [] }, { "id": "NCT02964416_exc_R4", "type": "Has_value", "arg1_id": "NCT02964416_exc_T13", "arg2_id": "NCT02964416_exc_T14", "normalized": [] }, { "id": "NCT02964416_exc_R5", "type": "AND", "arg1_id": "NCT02964416_exc_T16", "arg2_id": "NCT02964416_exc_T15", "normalized": [] }, { "id": "NCT02964416_exc_R6", "type": "Has_value", "arg1_id": "NCT02964416_exc_T16", "arg2_id": "NCT02964416_exc_T17", "normalized": [] }, { "id": "NCT02964416_exc_R7", "type": "Has_scope", "arg1_id": "NCT02964416_exc_T11", "arg2_id": "NCT02964416_exc_T18", "normalized": [] }, { "id": "NCT02964416_exc_R8", "type": "Has_value", "arg1_id": "NCT02964416_exc_T22", "arg2_id": "NCT02964416_exc_T23", "normalized": [] } ]

[ { "id": "NCT02964416_inc_text", "type": "inclusion", "text": [ "Patients with craniotomy for supratentorial tumors under general anesthesia\nAmerican Society of Anaesthesiologists (ASA) 2 and stable ASA 3 patients\nElective surgery\nPatients with Glasgow Coma Scale (GCS) 15/15\n" ], "offsets": [ [ 0, 211 ] ] } ]

[ { "id": "NCT02964416_inc_T1", "type": "Procedure", "text": [ "craniotomy" ], "offsets": [ [ 14, 24 ] ], "normalized": [] }, { "id": "NCT02964416_inc_T2", "type": "Condition", "text": [ "supratentorial tumors" ], "offsets": [ [ 29, 50 ] ], "normalized": [] }, { "id": "NCT02964416_inc_T3", "type": "Procedure", "text": [ "general anesthesia" ], "offsets": [ [ 57, 75 ] ], "normalized": [] }, { "id": "NCT02964416_inc_T4", "type": "Measurement", "text": [ "American Society of Anaesthesiologists" ], "offsets": [ [ 76, 114 ] ], "normalized": [] }, { "id": "NCT02964416_inc_T5", "type": "Measurement", "text": [ "ASA" ], "offsets": [ [ 116, 119 ] ], "normalized": [] }, { "id": "NCT02964416_inc_T6", "type": "Value", "text": [ "2" ], "offsets": [ [ 121, 122 ] ], "normalized": [] }, { "id": "NCT02964416_inc_T7", "type": "Measurement", "text": [ "ASA" ], "offsets": [ [ 134, 137 ] ], "normalized": [] }, { "id": "NCT02964416_inc_T8", "type": "Value", "text": [ "3" ], "offsets": [ [ 138, 139 ] ], "normalized": [] }, { "id": "NCT02964416_inc_T9", "type": "Qualifier", "text": [ "stable" ], "offsets": [ [ 127, 133 ] ], "normalized": [] }, { "id": "NCT02964416_inc_T10", "type": "Procedure", "text": [ "Elective surgery" ], "offsets": [ [ 149, 165 ] ], "normalized": [] }, { "id": "NCT02964416_inc_T11", "type": "Measurement", "text": [ "Glasgow Coma Scale" ], "offsets": [ [ 180, 198 ] ], "normalized": [] }, { "id": "NCT02964416_inc_T12", "type": "Measurement", "text": [ "GCS" ], "offsets": [ [ 200, 203 ] ], "normalized": [] }, { "id": "NCT02964416_inc_T13", "type": "Value", "text": [ "15/15" ], "offsets": [ [ 205, 210 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02964416_inc_R1", "type": "AND", "arg1_id": "NCT02964416_inc_T1", "arg2_id": "NCT02964416_inc_T2", "normalized": [] }, { "id": "NCT02964416_inc_R2", "type": "AND", "arg1_id": "NCT02964416_inc_T1", "arg2_id": "NCT02964416_inc_T3", "normalized": [] }, { "id": "NCT02964416_inc_R3", "type": "Subsumes", "arg1_id": "NCT02964416_inc_T4", "arg2_id": "NCT02964416_inc_T5", "normalized": [] }, { "id": "NCT02964416_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT02964416_inc_T7", "arg2_id": "NCT02964416_inc_T9", "normalized": [] }, { "id": "NCT02964416_inc_R5", "type": "Has_value", "arg1_id": "NCT02964416_inc_T7", "arg2_id": "NCT02964416_inc_T8", "normalized": [] }, { "id": "NCT02964416_inc_R6", "type": "Has_value", "arg1_id": "NCT02964416_inc_T4", "arg2_id": "NCT02964416_inc_T6", "normalized": [] }, { "id": "NCT02964416_inc_R7", "type": "Subsumes", "arg1_id": "NCT02964416_inc_T11", "arg2_id": "NCT02964416_inc_T12", "normalized": [] }, { "id": "NCT02964416_inc_R8", "type": "Has_value", "arg1_id": "NCT02964416_inc_T11", "arg2_id": "NCT02964416_inc_T13", "normalized": [] } ]

[ { "id": "NCT02964715_exc_text", "type": "exclusion", "text": [ "eGFR <45 ml/min\nstructural and functional urogenital abnormalities, that predispose for urogenital infections\nInvestigational product use in the last 6 months\nSGLT2 inhibitor, TZD, DPP4 inhibitor and GLP1 RA use within the past 6 months\nDKA(Diabetic Ketoacidosis) or HHS(Hyperosmoloar Hyperglycaemic Syndrome) within the last 6 months\nPregnancy\nPresence of major contraindications to magnetic resonance imaging (cardiac pacemakers, claustrophobia, foreign bodies and implanted medical devices with ferromagnetic properties).\nLiver cirrhosis\nType 1 diabetes\nSevere uncorrected insulin insufficiency\nSignificant alcohol intake\nHIV infection\nUse of Traditional Chinese Medication or alternative therapies\nCoexisting causes of chronic liver disease - chronic viral hepatitis(B & C), autoimmune liver disease, hemochromatosis, Wilson's etc.\nUse of medications associated with steatosis eg. Methotrexate, anticonvulsants, antiretroviral therapy etc.\nh/o stroke\nSteroid therapy\nEndogenous Cushing's\nFamilial hypertriglyceridemia\n" ], "offsets": [ [ 0, 1022 ] ] } ]

[ { "id": "NCT02964715_exc_T1", "type": "Measurement", "text": [ "eGFR" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T2", "type": "Value", "text": [ "<45 ml/min" ], "offsets": [ [ 5, 15 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T3", "type": "Condition", "text": [ "urogenital abnormalities" ], "offsets": [ [ 42, 66 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T4", "type": "Qualifier", "text": [ "structural" ], "offsets": [ [ 16, 26 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T5", "type": "Qualifier", "text": [ "functional" ], "offsets": [ [ 31, 41 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T7", "type": "Scope", "text": [ "structural and functional" ], "offsets": [ [ 16, 41 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T8", "type": "Observation", "text": [ "predispose for urogenital infections" ], "offsets": [ [ 73, 109 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T9", "type": "Condition", "text": [ "urogenital infections" ], "offsets": [ [ 88, 109 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T10", "type": "Procedure", "text": [ "Investigational product use" ], "offsets": [ [ 110, 137 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T11", "type": "Temporal", "text": [ "in the last 6 months" ], "offsets": [ [ 138, 158 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T12", "type": "Drug", "text": [ "SGLT2 inhibitor" ], "offsets": [ [ 159, 174 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T13", "type": "Drug", "text": [ "TZD" ], "offsets": [ [ 176, 179 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T14", "type": "Drug", "text": [ "DPP4 inhibitor" ], "offsets": [ [ 181, 195 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T15", "type": "Drug", "text": [ "GLP1 RA" ], "offsets": [ [ 200, 207 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T16", "type": "Temporal", "text": [ "within the past 6 months" ], "offsets": [ [ 212, 236 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T17", "type": "Scope", "text": [ "SGLT2 inhibitor, TZD, DPP4 inhibitor and GLP1 RA" ], "offsets": [ [ 159, 207 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T18", "type": "Condition", "text": [ "DKA" ], "offsets": [ [ 237, 240 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T19", "type": "Condition", "text": [ "Diabetic Ketoacidosis" ], "offsets": [ [ 241, 262 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T20", "type": "Condition", "text": [ "HHS" ], "offsets": [ [ 267, 270 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T21", "type": "Condition", "text": [ "Hyperosmoloar Hyperglycaemic Syndrome" ], "offsets": [ [ 271, 308 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T22", "type": "Temporal", "text": [ "within the last 6 months" ], "offsets": [ [ 310, 334 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T23", "type": "Scope", "text": [ "DKA(Diabetic Ketoacidosis) or HHS(Hyperosmoloar Hyperglycaemic Syndrome)" ], "offsets": [ [ 237, 309 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T25", "type": "Procedure", "text": [ "magnetic resonance imaging" ], "offsets": [ [ 384, 410 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T26", "type": "Observation", "text": [ "major contraindications" ], "offsets": [ [ 357, 380 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T27", "type": "Device", "text": [ "cardiac pacemakers" ], "offsets": [ [ 412, 430 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T28", "type": "Condition", "text": [ "claustrophobia" ], "offsets": [ [ 432, 446 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T29", "type": "Observation", "text": [ "foreign bodies" ], "offsets": [ [ 448, 462 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T30", "type": "Device", "text": [ "implanted medical devices" ], "offsets": [ [ 467, 492 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T31", "type": "Qualifier", "text": [ "ferromagnetic properties" ], "offsets": [ [ 498, 522 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T32", "type": "Condition", "text": [ "Liver cirrhosis" ], "offsets": [ [ 525, 540 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T33", "type": "Condition", "text": [ "Type 1 diabetes" ], "offsets": [ [ 541, 556 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T34", "type": "Condition", "text": [ "insulin insufficiency" ], "offsets": [ [ 576, 597 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T35", "type": "Qualifier", "text": [ "uncorrected" ], "offsets": [ [ 564, 575 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T36", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 557, 563 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T37", "type": "Scope", "text": [ "Severe uncorrected" ], "offsets": [ [ 557, 575 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T38", "type": "Observation", "text": [ "alcohol intake" ], "offsets": [ [ 610, 624 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T39", "type": "Qualifier", "text": [ "Significant" ], "offsets": [ [ 598, 609 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T40", "type": "Condition", "text": [ "HIV infection" ], "offsets": [ [ 625, 638 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T41", "type": "Procedure", "text": [ "Traditional Chinese Medication" ], "offsets": [ [ 646, 676 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T42", "type": "Procedure", "text": [ "alternative therapies" ], "offsets": [ [ 680, 701 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T43", "type": "Condition", "text": [ "chronic liver disease" ], "offsets": [ [ 723, 744 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T44", "type": "Condition", "text": [ " hepatitis(B & C), aut", "m" ], "offsets": [ [ 760, 782 ], [ 784, 785 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T45", "type": "Condition", "text": [ " hepatitis(B & C), aut", "e" ], "offsets": [ [ 760, 782 ], [ 788, 789 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T47", "type": "Condition", "text": [ "autoimmune liver disease" ], "offsets": [ [ 779, 803 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T48", "type": "Condition", "text": [ "hemochromatosis" ], "offsets": [ [ 805, 820 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T49", "type": "Condition", "text": [ "Wilson's" ], "offsets": [ [ 822, 830 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T50", "type": "Scope", "text": [ "chronic viral hepatitis(B & C), autoimmune liver disease, hemochromatosis, Wilson's" ], "offsets": [ [ 747, 830 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T51", "type": "Drug", "text": [ "medications" ], "offsets": [ [ 843, 854 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T52", "type": "Condition", "text": [ "steatosis" ], "offsets": [ [ 871, 880 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T53", "type": "Drug", "text": [ "Methotrexate" ], "offsets": [ [ 885, 897 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T54", "type": "Drug", "text": [ "anticonvulsants" ], "offsets": [ [ 899, 914 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T55", "type": "Drug", "text": [ "antiretroviral therapy" ], "offsets": [ [ 916, 938 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T56", "type": "Scope", "text": [ "Methotrexate, anticonvulsants, antiretroviral therapy" ], "offsets": [ [ 885, 938 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T57", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 948, 954 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T58", "type": "Drug", "text": [ "Steroid therapy" ], "offsets": [ [ 955, 970 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T59", "type": "Condition", "text": [ "Cushing's" ], "offsets": [ [ 982, 991 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T60", "type": "Qualifier", "text": [ "Endogenous" ], "offsets": [ [ 971, 981 ] ], "normalized": [] }, { "id": "NCT02964715_exc_T61", "type": "Condition", "text": [ "Familial hypertriglyceridemi" ], "offsets": [ [ 992, 1020 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02964715_exc_R1", "type": "Has_value", "arg1_id": "NCT02964715_exc_T1", "arg2_id": "NCT02964715_exc_T2", "normalized": [] }, { "id": "NCT02964715_exc_R2", "type": "Has_scope", "arg1_id": "NCT02964715_exc_T3", "arg2_id": "NCT02964715_exc_T7", "normalized": [] }, { "id": "NCT02964715_exc_R4", "type": "Has_temporal", "arg1_id": "NCT02964715_exc_T10", "arg2_id": "NCT02964715_exc_T11", "normalized": [] }, { "id": "NCT02964715_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02964715_exc_T17", "arg2_id": "NCT02964715_exc_T16", "normalized": [] }, { "id": "NCT02964715_exc_R6", "type": "Subsumes", "arg1_id": "NCT02964715_exc_T18", "arg2_id": "NCT02964715_exc_T19", "normalized": [] }, { "id": "NCT02964715_exc_R7", "type": "Subsumes", "arg1_id": "NCT02964715_exc_T20", "arg2_id": "NCT02964715_exc_T21", "normalized": [] }, { "id": "NCT02964715_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02964715_exc_T23", "arg2_id": "NCT02964715_exc_T22", "normalized": [] }, { "id": "NCT02964715_exc_R9", "type": "AND", "arg1_id": "NCT02964715_exc_T26", "arg2_id": "NCT02964715_exc_T25", "normalized": [] }, { "id": "NCT02964715_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT02964715_exc_T30", "arg2_id": "NCT02964715_exc_T31", "normalized": [] }, { "id": "NCT02964715_exc_R11", "type": "Has_scope", "arg1_id": "NCT02964715_exc_T34", "arg2_id": "NCT02964715_exc_T37", "normalized": [] }, { "id": "NCT02964715_exc_R12", "type": "Has_qualifier", "arg1_id": "NCT02964715_exc_T38", "arg2_id": "NCT02964715_exc_T39", "normalized": [] }, { "id": "NCT02964715_exc_R13", "type": "Subsumes", "arg1_id": "NCT02964715_exc_T43", "arg2_id": "NCT02964715_exc_T50", "normalized": [] }, { "id": "NCT02964715_exc_R14", "type": "AND", "arg1_id": "NCT02964715_exc_T51", "arg2_id": "NCT02964715_exc_T52", "normalized": [] }, { "id": "NCT02964715_exc_R15", "type": "Subsumes", "arg1_id": "NCT02964715_exc_T51", "arg2_id": "NCT02964715_exc_T56", "normalized": [] }, { "id": "NCT02964715_exc_R16", "type": "Has_qualifier", "arg1_id": "NCT02964715_exc_T59", "arg2_id": "NCT02964715_exc_T60", "normalized": [] } ]

[ { "id": "NCT02964715_inc_text", "type": "inclusion", "text": [ "biopsy proven NASH\nType 2 DM\nHbA1c :>6.5%\nBMI < 45kg/m2\nAny anti-diabetic agent except SGLT2 inhibitors, TZDs(thiazolidinediones), DPP4(Dipeptidyl peptidase4) inhibitors and GLP1 RAs(Glucagon-like Peptide 1-Receptor Agonists)\n" ], "offsets": [ [ 0, 226 ] ] } ]

[ { "id": "NCT02964715_inc_T1", "type": "Condition", "text": [ "NASH" ], "offsets": [ [ 14, 18 ] ], "normalized": [] }, { "id": "NCT02964715_inc_T2", "type": "Procedure", "text": [ "biopsy" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "NCT02964715_inc_T3", "type": "Condition", "text": [ "Type 2 DM" ], "offsets": [ [ 19, 28 ] ], "normalized": [] }, { "id": "NCT02964715_inc_T4", "type": "Measurement", "text": [ "HbA1c" ], "offsets": [ [ 29, 34 ] ], "normalized": [] }, { "id": "NCT02964715_inc_T5", "type": "Value", "text": [ ">6.5%" ], "offsets": [ [ 36, 41 ] ], "normalized": [] }, { "id": "NCT02964715_inc_T6", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 42, 45 ] ], "normalized": [] }, { "id": "NCT02964715_inc_T7", "type": "Value", "text": [ "< 45kg/m2" ], "offsets": [ [ 46, 55 ] ], "normalized": [] }, { "id": "NCT02964715_inc_T8", "type": "Drug", "text": [ "anti-diabetic agent" ], "offsets": [ [ 60, 79 ] ], "normalized": [] }, { "id": "NCT02964715_inc_T9", "type": "Negation", "text": [ "except" ], "offsets": [ [ 80, 86 ] ], "normalized": [] }, { "id": "NCT02964715_inc_T10", "type": "Drug", "text": [ "SGLT2 inhibitors" ], "offsets": [ [ 87, 103 ] ], "normalized": [] }, { "id": "NCT02964715_inc_T11", "type": "Drug", "text": [ "TZDs" ], "offsets": [ [ 105, 109 ] ], "normalized": [] }, { "id": "NCT02964715_inc_T12", "type": "Drug", "text": [ "thiazolidinediones" ], "offsets": [ [ 110, 128 ] ], "normalized": [] }, { "id": "NCT02964715_inc_T13", "type": "Drug", "text": [ "(Dip", "bitors and" ], "offsets": [ [ 135, 139 ], [ 163, 173 ] ], "normalized": [] }, { "id": "NCT02964715_inc_T14", "type": "Drug", "text": [ "ptidyl peptidase4) in", "bitors and" ], "offsets": [ [ 140, 161 ], [ 163, 173 ] ], "normalized": [] }, { "id": "NCT02964715_inc_T15", "type": "Drug", "text": [ "GLP1 RAs" ], "offsets": [ [ 174, 182 ] ], "normalized": [] }, { "id": "NCT02964715_inc_T16", "type": "Drug", "text": [ "Glucagon-like Peptide 1-Receptor Agonists" ], "offsets": [ [ 183, 224 ] ], "normalized": [] }, { "id": "NCT02964715_inc_T17", "type": "Scope", "text": [ "SGLT2 inhibitors, TZDs(thiazolidinediones), DPP4(Dipeptidyl peptidase4) inhibitors and GLP1 RAs(Glucagon-like Peptide 1-Receptor Agonists" ], "offsets": [ [ 87, 224 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02964715_inc_R1", "type": "AND", "arg1_id": "NCT02964715_inc_T2", "arg2_id": "NCT02964715_inc_T1", "normalized": [] }, { "id": "NCT02964715_inc_R2", "type": "Has_value", "arg1_id": "NCT02964715_inc_T4", "arg2_id": "NCT02964715_inc_T5", "normalized": [] }, { "id": "NCT02964715_inc_R3", "type": "Has_value", "arg1_id": "NCT02964715_inc_T6", "arg2_id": "NCT02964715_inc_T7", "normalized": [] }, { "id": "NCT02964715_inc_R4", "type": "Subsumes", "arg1_id": "NCT02964715_inc_T15", "arg2_id": "NCT02964715_inc_T16", "normalized": [] }, { "id": "NCT02964715_inc_R5", "type": "Subsumes", "arg1_id": "NCT02964715_inc_T13", "arg2_id": "NCT02964715_inc_T14", "normalized": [] }, { "id": "NCT02964715_inc_R6", "type": "Subsumes", "arg1_id": "NCT02964715_inc_T11", "arg2_id": "NCT02964715_inc_T12", "normalized": [] }, { "id": "NCT02964715_inc_R7", "type": "Has_negation", "arg1_id": "NCT02964715_inc_T17", "arg2_id": "NCT02964715_inc_T9", "normalized": [] } ]

[ { "id": "NCT02965027_exc_text", "type": "exclusion", "text": [ "Participation in other interventional research.\nHistory of penetrating head injury\nHistory of TBI more severe than mild by DVBIC criteria\nDiagnosis of a primary or secondary HA disorder other than PTHA\nLifetime history of 5 or more migraine or probable migraine headaches pre-dating mTBI\nHAs of any kind of moderate or severe intensity on an average of more than 2 days per month preceding the concussive trauma\nContinuous HAs of any kind (i.e., persistent daily HAs with no HA-free period less than 8 hours between attacks)\nAcute or serious medical illness or unstable chronic medical illness (e.g., unstable angina, myocardial infarction within 6 months, congestive heart failure, clinically significant or concerning cardiac arrhythmias; preexisting hypotension [systolic blood pressure<110] or orthostatic hypotension [systolic drop >20 mm Hg after 2 min standing accompanied by lightheadedness], chronic renal or hepatic failure, acute pancreatitis, Meniere's disease, or diagnosed but untreated sleep apnea). The eligibility of potential participants having acute serious and/or chronic medical illnesses other than those listed will be evaluated on a case-by-case basis by a study physician, PA-C, or ARNP.\nUse of prazosin or other alpha-1 antagonist (including but not limited to alfuzosin, doxazosin, silodosin, tamsulosin, terazosin) for any purpose in the 2 weeks prior to initial screen (P1) visit and prohibited throughout the study\nAllergy or previous adverse reaction to prazosin or other alpha-1 antagonist\nActive psychosis or psychotic disorder, severe depression (as determined per clinician prescriber judgment), severe psychiatric instability or severe situational life crisis (including evidence of being actively suicidal or homicidal).\nMeets Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria for any Substance Use Disorder except caffeine-related disorders, or tobacco-related disorders.\nHistory of delirium within the prior 3 months, epilepsy, stroke, dementia, psychotic disorder, or bipolar disorder\nStructural brain abnormalities on any prior imaging with associated clinically evident manifestations\nCurrent participation in transcranial magnetic stimulation studies\nWomen of childbearing potential must not be pregnant, planning to become pregnant during the study period, or nursing.\nParticipation in a HA support group or other activity such as meditation or yoga intended to mitigate HA or other chronic pain must be stable at least 4 weeks prior to beginning the initial screen (P1) visit and may not be started during the study\nFailure to record HA data for at least 80% of days during the Screening Period\nNot suitable for study per clinician judgement.\nThe use of HA rescue or symptom-relieving medications will be allowed during the study. This includes triptans, ergotamines, opioids, simple analgesics (e.g. acetaminophen, aspirin, or non-steroidal anti-inflammatories [NSAIDS], and combination analgesics. Their use will be recorded on the concurrent medication CRF during the Preliminary Screening Period (P1) and throughout the remainder of the study. Randomization of participants will be stratified based on whether their use of HA medications meets ICHD-3 beta criteria for overuse of these medications, as described in section 5.5 below.\nOpioid Medications: Use of opioids for treatment of HA or non-HA-related pain or for any other purpose is allowed during the study. Any opioid use would ideally be excluded due to potential confounding effects on interpretation of response to treatment. However, in this population, particularly in Veterans with chronic pain or undergoing minor orthopedic or dental procedures, opioid use is common. Use of opioids, including frequency and dose, will be recorded on the concurrent medication CRF.\nOther Medications: Participants who are taking other medications on a routine basis must be on a stable dose for at least 4 weeks prior to the Preliminary Screening Period (P1), and must intend to continue the medication at the same regimen for the duration of the trial unless lack of efficacy, safety, or tolerability dictates otherwise. The following medications are not excluded:\nPsychoactive drugs (for example, anticonvulsants, benzodiazepines, antidepressants, sedative/hypnotics),\nAntihypertensive medications (including beta-blockers, calcium channel blockers, angiotensin converting enzyme [ACE] inhibitors, and angiotensin receptor blockers),\nThe use of magnesium in any dose that is prescribed for the purpose of HA prevention or treatment must be stable for at least 4 weeks. The incidental use of magnesium in multi-vitamins, laxatives, etc. is permissible but must be documented.\nHormones (for example, testosterone, estrogen, or progesterone) in any form.\nThe \"as-needed\" (prn) use of psychoactive and other drugs such as antibiotics is not excluded; however, such use must be discussed with a clinician prescriber and documented.\nThe use of butalbital in any form within 4 weeks of beginning the Preliminary Screening Period (P1) through the end of the participant's study involvement is exclusionary.\nParticipants who have been taking trazodone will undergo a 2-week washout period before the Preliminary Screening Period (P1 visit). Combining prazosin and trazodone may increase the risk of priapism. We have decided to begin the washout period before the Preliminary Screening Period in order to remove any confounding variables while on the headache log and actigraphy.\nSildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra), and avanafil (Stendra) will not be permitted during the study drug dose Titration Period, because of increased risk of hypotension in combination with alpha-1 blockers, but will be allowed at half the usual starting dose following the study drug dose Titration Period, per VA prescribing guidelines.\nUse of supplements containing nitrates and supplements containing stimulants (such as ephedra) are exclusionary in the two weeks prior to initial screen (P1) visit and prohibited throughout the study. Participants who take these supplements will be asked to discontinue them for a minimum of two weeks before the Preliminary Screening Period (P1 visit)..\nUse of prescribed stimulants (such as amphetamine or dextroamphetamine containing medications) is exclusionary in the 2 weeks prior to the initial screen (P1) visit and prohibited throughout the study. Participants who take these medications will be asked to discontinue them for a minimum of 2 weeks before the Preliminary Screening Period.\n" ], "offsets": [ [ 0, 6567 ] ] } ]

[ { "id": "NCT02965027_exc_T2", "type": "Condition", "text": [ "penetrating head injury" ], "offsets": [ [ 59, 82 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T3", "type": "Condition", "text": [ "TBI" ], "offsets": [ [ 94, 97 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T4", "type": "Value", "text": [ "more severe than mild" ], "offsets": [ [ 98, 119 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T5", "type": "Measurement", "text": [ "DVBIC criteria" ], "offsets": [ [ 123, 137 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T6", "type": "Qualifier", "text": [ "primary" ], "offsets": [ [ 153, 160 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T7", "type": "Qualifier", "text": [ "secondary" ], "offsets": [ [ 164, 173 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T8", "type": "Condition", "text": [ "HA disorder" ], "offsets": [ [ 174, 185 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T9", "type": "Condition", "text": [ "PTHA" ], "offsets": [ [ 197, 201 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T10", "type": "Negation", "text": [ "other than" ], "offsets": [ [ 186, 196 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T11", "type": "Scope", "text": [ "primary or secondary" ], "offsets": [ [ 153, 173 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T12", "type": "Observation", "text": [ "Lifetime history" ], "offsets": [ [ 202, 218 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T13", "type": "Multiplier", "text": [ "5 or more" ], "offsets": [ [ 222, 231 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T14", "type": "Condition", "text": [ "migraine" ], "offsets": [ [ 232, 240 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T15", "type": "Qualifier", "text": [ "probable" ], "offsets": [ [ 244, 252 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T16", "type": "Condition", "text": [ "migraine" ], "offsets": [ [ 253, 261 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T17", "type": "Temporal", "text": [ "pre-dating mTBI" ], "offsets": [ [ 272, 287 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T18", "type": "Procedure", "text": [ "mTBI" ], "offsets": [ [ 283, 287 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T19", "type": "Reference_point", "text": [ "mTBI" ], "offsets": [ [ 283, 287 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T20", "type": "Scope", "text": [ "migraine or probable migraine" ], "offsets": [ [ 232, 261 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T21", "type": "Condition", "text": [ "HAs" ], "offsets": [ [ 288, 291 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T22", "type": "Qualifier", "text": [ "moderate or severe intensity" ], "offsets": [ [ 307, 335 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T23", "type": "Multiplier", "text": [ "average of more than 2 days per month" ], "offsets": [ [ 342, 379 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T24", "type": "Temporal", "text": [ "preceding the concussive trauma" ], "offsets": [ [ 380, 411 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T25", "type": "Condition", "text": [ "HAs" ], "offsets": [ [ 423, 426 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T26", "type": "Qualifier", "text": [ "Continuous" ], "offsets": [ [ 412, 422 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T27", "type": "Qualifier", "text": [ "persistent" ], "offsets": [ [ 446, 456 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T28", "type": "Multiplier", "text": [ "daily" ], "offsets": [ [ 457, 462 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T29", "type": "Measurement", "text": [ "e period less", "n attacks)\nAcut" ], "offsets": [ [ 481, 494 ], [ 514, 529 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T30", "type": "Value", "text": [ "less than 8 hours" ], "offsets": [ [ 490, 507 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T31", "type": "Negation", "text": [ "no" ], "offsets": [ [ 472, 474 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T32", "type": "Condition", "text": [ "HAs" ], "offsets": [ [ 463, 466 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T33", "type": "Qualifier", "text": [ "Acute" ], "offsets": [ [ 525, 530 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T34", "type": "Qualifier", "text": [ "serious" ], "offsets": [ [ 534, 541 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T35", "type": "Condition", "text": [ "medical illness" ], "offsets": [ [ 542, 557 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T36", "type": "Qualifier", "text": [ "unstable" ], "offsets": [ [ 561, 569 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T37", "type": "Condition", "text": [ "chronic medical illness" ], "offsets": [ [ 570, 593 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T38", "type": "Condition", "text": [ "unstable angina" ], "offsets": [ [ 601, 616 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T39", "type": "Condition", "text": [ "myocardial infarction" ], "offsets": [ [ 618, 639 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T40", "type": "Temporal", "text": [ "within 6 months" ], "offsets": [ [ 640, 655 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T41", "type": "Condition", "text": [ "congestive heart failure" ], "offsets": [ [ 657, 681 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T42", "type": "Qualifier", "text": [ "clinically significant" ], "offsets": [ [ 683, 705 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T43", "type": "Qualifier", "text": [ "concerning" ], "offsets": [ [ 709, 719 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T44", "type": "Condition", "text": [ "cardiac arrhythmias" ], "offsets": [ [ 720, 739 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T45", "type": "Temporal", "text": [ "preexisting" ], "offsets": [ [ 741, 752 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T46", "type": "Condition", "text": [ "hypotension" ], "offsets": [ [ 753, 764 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T47", "type": "Measurement", "text": [ "systolic blood pressure" ], "offsets": [ [ 766, 789 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T48", "type": "Value", "text": [ "<110" ], "offsets": [ [ 789, 793 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T49", "type": "Condition", "text": [ "orthostatic hypotension" ], "offsets": [ [ 798, 821 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T50", "type": "Measurement", "text": [ "systolic drop" ], "offsets": [ [ 823, 836 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T51", "type": "Value", "text": [ ">20 mm Hg" ], "offsets": [ [ 837, 846 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T52", "type": "Temporal", "text": [ "after 2 min standing" ], "offsets": [ [ 847, 867 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T53", "type": "Condition", "text": [ "lightheadedness" ], "offsets": [ [ 883, 898 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T54", "type": "Condition", "text": [ " renal or he", ", acute" ], "offsets": [ [ 908, 920 ], [ 933, 940 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T55", "type": "Condition", "text": [ "hepatic failure" ], "offsets": [ [ 918, 933 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T56", "type": "Condition", "text": [ "acute pancreatitis" ], "offsets": [ [ 935, 953 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T57", "type": "Condition", "text": [ "Meniere's disease" ], "offsets": [ [ 955, 972 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T58", "type": "Condition", "text": [ "sleep apnea" ], "offsets": [ [ 1001, 1012 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T59", "type": "Qualifier", "text": [ "untreated" ], "offsets": [ [ 991, 1000 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T61", "type": "Scope", "text": [ "Acute or serious" ], "offsets": [ [ 525, 541 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T62", "type": "Scope", "text": [ "clinically significant or concerning" ], "offsets": [ [ 683, 719 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T63", "type": "Scope", "text": [ "systolic drop >20 mm Hg after 2 min standing accompanied by lightheadedness" ], "offsets": [ [ 823, 898 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T64", "type": "Scope", "text": [ "unstable angina, myocardial infarction within 6 months, congestive heart failure, clinically significant or concerning cardiac arrhythmias; preexisting hypotension [systolic blood pressure<110] or orthostatic hypotension [systolic drop >20 mm Hg after 2 min standing accompanied by lightheadedness], chronic renal or hepatic failure, acute pancreatitis, Meniere's disease, or diagnosed but untreated sleep apnea" ], "offsets": [ [ 601, 1012 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T65", "type": "Scope", "text": [ "Acute or serious medical illness or unstable chronic medical illness" ], "offsets": [ [ 525, 593 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T66", "type": "Drug", "text": [ "prazosin" ], "offsets": [ [ 1221, 1229 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T67", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 1233, 1238 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T68", "type": "Drug", "text": [ "alpha-1 antagonist" ], "offsets": [ [ 1239, 1257 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T69", "type": "Drug", "text": [ "alfuzosin" ], "offsets": [ [ 1288, 1297 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T70", "type": "Drug", "text": [ "doxazosin" ], "offsets": [ [ 1299, 1308 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T71", "type": "Drug", "text": [ "silodosin" ], "offsets": [ [ 1310, 1319 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T72", "type": "Drug", "text": [ "tamsulosin" ], "offsets": [ [ 1321, 1331 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T73", "type": "Drug", "text": [ "terazosin" ], "offsets": [ [ 1333, 1342 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T74", "type": "Temporal", "text": [ "in the 2 weeks prior to initial screen (P1) visit" ], "offsets": [ [ 1360, 1409 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T75", "type": "Reference_point", "text": [ "initial screen (P1) visit" ], "offsets": [ [ 1384, 1409 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T76", "type": "Scope", "text": [ "prazosin or other alpha-1 antagonist" ], "offsets": [ [ 1221, 1257 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T77", "type": "Scope", "text": [ "alfuzosin, doxazosin, silodosin, tamsulosin, terazosin" ], "offsets": [ [ 1288, 1342 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T78", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 1446, 1453 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T79", "type": "Condition", "text": [ "adverse reaction" ], "offsets": [ [ 1466, 1482 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T80", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 1457, 1465 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T81", "type": "Drug", "text": [ "prazosin" ], "offsets": [ [ 1486, 1494 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T82", "type": "Drug", "text": [ "alpha-1 antagonist" ], "offsets": [ [ 1504, 1522 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T83", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 1498, 1503 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T84", "type": "Scope", "text": [ "prazosin or other alpha-1 antagonist" ], "offsets": [ [ 1486, 1522 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T85", "type": "Scope", "text": [ "Allergy or previous adverse reaction" ], "offsets": [ [ 1446, 1482 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T86", "type": "Condition", "text": [ "psychotic disorder" ], "offsets": [ [ 1543, 1561 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T87", "type": "Condition", "text": [ "psychosis" ], "offsets": [ [ 1530, 1539 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T88", "type": "Qualifier", "text": [ "Active" ], "offsets": [ [ 1523, 1529 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T89", "type": "Condition", "text": [ "severe depression" ], "offsets": [ [ 1563, 1580 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T90", "type": "Condition", "text": [ "psychiatric instability" ], "offsets": [ [ 1639, 1662 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T91", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 1632, 1638 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T92", "type": "Condition", "text": [ "situational life crisis" ], "offsets": [ [ 1673, 1696 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T93", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 1666, 1672 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T94", "type": "Condition", "text": [ "suicidal" ], "offsets": [ [ 1735, 1743 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T95", "type": "Condition", "text": [ "homicidal" ], "offsets": [ [ 1747, 1756 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T96", "type": "Scope", "text": [ "suicidal or homicidal" ], "offsets": [ [ 1735, 1756 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T97", "type": "Condition", "text": [ "Substance Use Disorder" ], "offsets": [ [ 1857, 1879 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T98", "type": "Condition", "text": [ "caffeine-related disorders" ], "offsets": [ [ 1887, 1913 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T99", "type": "Negation", "text": [ "except" ], "offsets": [ [ 1880, 1886 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T100", "type": "Condition", "text": [ "tobacco-related disorders" ], "offsets": [ [ 1918, 1943 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T101", "type": "Scope", "text": [ "caffeine-related disorders, or tobacco-related disorders" ], "offsets": [ [ 1887, 1943 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T102", "type": "Measurement", "text": [ "Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria" ], "offsets": [ [ 1765, 1848 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T103", "type": "Value", "text": [ "Meets" ], "offsets": [ [ 1759, 1764 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T104", "type": "Condition", "text": [ "delirium" ], "offsets": [ [ 1956, 1964 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T105", "type": "Temporal", "text": [ "within the prior 3 months" ], "offsets": [ [ 1965, 1990 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T106", "type": "Condition", "text": [ "epilepsy" ], "offsets": [ [ 1992, 2000 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T107", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 2002, 2008 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T108", "type": "Condition", "text": [ "dementia" ], "offsets": [ [ 2010, 2018 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T109", "type": "Condition", "text": [ "psychotic disorder" ], "offsets": [ [ 2020, 2038 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T110", "type": "Condition", "text": [ "bipolar disorder" ], "offsets": [ [ 2043, 2059 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T111", "type": "Condition", "text": [ "Structural brain abnormalities" ], "offsets": [ [ 2060, 2090 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T112", "type": "Procedure", "text": [ "imaging" ], "offsets": [ [ 2104, 2111 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T113", "type": "Temporal", "text": [ "prior" ], "offsets": [ [ 2098, 2103 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T114", "type": "Qualifier", "text": [ "any" ], "offsets": [ [ 2094, 2097 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T115", "type": "Qualifier", "text": [ "clinically evident" ], "offsets": [ [ 2128, 2146 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T116", "type": "Condition", "text": [ "manifestations" ], "offsets": [ [ 2147, 2161 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T117", "type": "Procedure", "text": [ "transcranial magnetic stimulation studies" ], "offsets": [ [ 2187, 2228 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T118", "type": "Temporal", "text": [ "Current" ], "offsets": [ [ 2162, 2169 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T119", "type": "Condition", "text": [ "childbearing potential" ], "offsets": [ [ 2238, 2260 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T120", "type": "Person", "text": [ "Women" ], "offsets": [ [ 2229, 2234 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T121", "type": "Negation", "text": [ "not be" ], "offsets": [ [ 2266, 2272 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T122", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 2302, 2310 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T123", "type": "Mood", "text": [ "planning to become" ], "offsets": [ [ 2283, 2301 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T124", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 2302, 2310 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T125", "type": "Temporal", "text": [ "during the study period" ], "offsets": [ [ 2311, 2334 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T126", "type": "Condition", "text": [ "nursing" ], "offsets": [ [ 2339, 2346 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T127", "type": "Scope", "text": [ "pregnant, planning to become pregnant during the study period, or nursing" ], "offsets": [ [ 2273, 2346 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T128", "type": "Scope", "text": [ "Women of childbearing potential" ], "offsets": [ [ 2229, 2260 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T129", "type": "Procedure", "text": [ "Participation in a HA support group" ], "offsets": [ [ 2348, 2383 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T130", "type": "Procedure", "text": [ "meditation" ], "offsets": [ [ 2410, 2420 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T131", "type": "Procedure", "text": [ "yoga" ], "offsets": [ [ 2424, 2428 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T133", "type": "Observation", "text": [ "Failure to record HA data" ], "offsets": [ [ 2596, 2621 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T134", "type": "Multiplier", "text": [ "for at least 80% of days" ], "offsets": [ [ 2622, 2646 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T135", "type": "Temporal", "text": [ "during the Screening Period" ], "offsets": [ [ 2647, 2674 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T139", "type": "Drug", "text": [ "medications" ], "offsets": [ [ 3869, 3880 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T140", "type": "Multiplier", "text": [ "on a routine basis" ], "offsets": [ [ 3881, 3899 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T141", "type": "Qualifier", "text": [ "stable dose" ], "offsets": [ [ 3913, 3924 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T142", "type": "Temporal", "text": [ "for at least 4 weeks prior to the Preliminary Screening Period (P1)" ], "offsets": [ [ 3925, 3992 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T143", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 3863, 3868 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T144", "type": "Scope", "text": [ "other medications on a routine basis" ], "offsets": [ [ 3863, 3899 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T151", "type": "Drug", "text": [ "butalbital" ], "offsets": [ [ 4974, 4984 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T152", "type": "Temporal", "text": [ "within 4 weeks of beginning the Preliminary Screening Period (P1)" ], "offsets": [ [ 4997, 5062 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T154", "type": "Drug", "text": [ "Sildenafil" ], "offsets": [ [ 5507, 5517 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T155", "type": "Drug", "text": [ "Viagra" ], "offsets": [ [ 5519, 5525 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T156", "type": "Drug", "text": [ "tadalafil" ], "offsets": [ [ 5528, 5537 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T157", "type": "Drug", "text": [ "Cialis" ], "offsets": [ [ 5539, 5545 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T158", "type": "Drug", "text": [ "vardenafil" ], "offsets": [ [ 5548, 5558 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T159", "type": "Drug", "text": [ "Levitra" ], "offsets": [ [ 5560, 5567 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T160", "type": "Drug", "text": [ "avanafil" ], "offsets": [ [ 5574, 5582 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T161", "type": "Drug", "text": [ "Stendra" ], "offsets": [ [ 5584, 5591 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T162", "type": "Temporal", "text": [ "during the study drug dose Titration Period" ], "offsets": [ [ 5615, 5658 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T163", "type": "Scope", "text": [ "Sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra), and avanafil (Stendra)" ], "offsets": [ [ 5507, 5592 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T164", "type": "Drug", "text": [ "nitrates" ], "offsets": [ [ 5900, 5908 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T165", "type": "Drug", "text": [ "stimulants" ], "offsets": [ [ 5936, 5946 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T166", "type": "Drug", "text": [ "ephedra" ], "offsets": [ [ 5956, 5963 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T167", "type": "Temporal", "text": [ "in the two weeks prior to initial screen (P1) visit" ], "offsets": [ [ 5982, 6033 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T168", "type": "Scope", "text": [ "nitrates and supplements containing stimulants (such as ephedra)" ], "offsets": [ [ 5900, 5964 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T169", "type": "Drug", "text": [ "prescribed stimulants" ], "offsets": [ [ 6232, 6253 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T170", "type": "Drug", "text": [ "amphetamine" ], "offsets": [ [ 6284, 6295 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T171", "type": "Drug", "text": [ "dextroamphetamine" ], "offsets": [ [ 6278, 6295 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T172", "type": "Scope", "text": [ "amphetamine or dextroamphetamine" ], "offsets": [ [ 6263, 6295 ] ], "normalized": [] }, { "id": "NCT02965027_exc_T173", "type": "Temporal", "text": [ "in the 2 weeks prior to the initial screen (P1) visit" ], "offsets": [ [ 6336, 6389 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02965027_exc_R1", "type": "Has_value", "arg1_id": "NCT02965027_exc_T5", "arg2_id": "NCT02965027_exc_T4", "normalized": [] }, { "id": "NCT02965027_exc_R2", "type": "AND", "arg1_id": "NCT02965027_exc_T3", "arg2_id": "NCT02965027_exc_T5", "normalized": [] }, { "id": "NCT02965027_exc_R3", "type": "Has_negation", "arg1_id": "NCT02965027_exc_T9", "arg2_id": "NCT02965027_exc_T10", "normalized": [] }, { "id": "NCT02965027_exc_R4", "type": "AND", "arg1_id": "NCT02965027_exc_T8", "arg2_id": "NCT02965027_exc_T9", "normalized": [] }, { "id": "NCT02965027_exc_R5", "type": "Has_scope", "arg1_id": "NCT02965027_exc_T8", "arg2_id": "NCT02965027_exc_T11", "normalized": [] }, { "id": "NCT02965027_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02965027_exc_T16", "arg2_id": "NCT02965027_exc_T15", "normalized": [] }, { "id": "NCT02965027_exc_R7", "type": "Has_index", "arg1_id": "NCT02965027_exc_T17", "arg2_id": "NCT02965027_exc_T19", "normalized": [] }, { "id": "NCT02965027_exc_R9", "type": "Has_multiplier", "arg1_id": "NCT02965027_exc_T20", "arg2_id": "NCT02965027_exc_T13", "normalized": [] }, { "id": "NCT02965027_exc_R10", "type": "Has_temporal", "arg1_id": "NCT02965027_exc_T20", "arg2_id": "NCT02965027_exc_T12", "normalized": [] }, { "id": "NCT02965027_exc_R11", "type": "Has_temporal", "arg1_id": "NCT02965027_exc_T20", "arg2_id": "NCT02965027_exc_T17", "normalized": [] }, { "id": "NCT02965027_exc_R12", "type": "Has_multiplier", "arg1_id": "NCT02965027_exc_T21", "arg2_id": "NCT02965027_exc_T23", "normalized": [] }, { "id": "NCT02965027_exc_R13", "type": "Has_temporal", "arg1_id": "NCT02965027_exc_T21", "arg2_id": "NCT02965027_exc_T24", "normalized": [] }, { "id": "NCT02965027_exc_R14", "type": "Has_qualifier", "arg1_id": "NCT02965027_exc_T21", "arg2_id": "NCT02965027_exc_T22", "normalized": [] }, { "id": "NCT02965027_exc_R15", "type": "Has_qualifier", "arg1_id": "NCT02965027_exc_T25", "arg2_id": "NCT02965027_exc_T26", "normalized": [] }, { "id": "NCT02965027_exc_R16", "type": "Has_value", "arg1_id": "NCT02965027_exc_T29", "arg2_id": "NCT02965027_exc_T30", "normalized": [] }, { "id": "NCT02965027_exc_R17", "type": "Has_negation", "arg1_id": "NCT02965027_exc_T29", "arg2_id": "NCT02965027_exc_T31", "normalized": [] }, { "id": "NCT02965027_exc_R18", "type": "Has_multiplier", "arg1_id": "NCT02965027_exc_T32", "arg2_id": "NCT02965027_exc_T28", "normalized": [] }, { "id": "NCT02965027_exc_R19", "type": "Has_qualifier", "arg1_id": "NCT02965027_exc_T32", "arg2_id": "NCT02965027_exc_T27", "normalized": [] }, { "id": "NCT02965027_exc_R20", "type": "AND", "arg1_id": "NCT02965027_exc_T32", "arg2_id": "NCT02965027_exc_T29", "normalized": [] }, { "id": "NCT02965027_exc_R21", "type": "Subsumes", "arg1_id": "NCT02965027_exc_T25", "arg2_id": "NCT02965027_exc_T32", "normalized": [] }, { "id": "NCT02965027_exc_R22", "type": "Has_temporal", "arg1_id": "NCT02965027_exc_T39", "arg2_id": "NCT02965027_exc_T40", "normalized": [] }, { "id": "NCT02965027_exc_R23", "type": "Has_scope", "arg1_id": "NCT02965027_exc_T35", "arg2_id": "NCT02965027_exc_T61", "normalized": [] }, { "id": "NCT02965027_exc_R24", "type": "Has_qualifier", "arg1_id": "NCT02965027_exc_T37", "arg2_id": "NCT02965027_exc_T36", "normalized": [] }, { "id": "NCT02965027_exc_R25", "type": "Has_scope", "arg1_id": "NCT02965027_exc_T44", "arg2_id": "NCT02965027_exc_T62", "normalized": [] }, { "id": "NCT02965027_exc_R26", "type": "Has_temporal", "arg1_id": "NCT02965027_exc_T46", "arg2_id": "NCT02965027_exc_T45", "normalized": [] }, { "id": "NCT02965027_exc_R27", "type": "Has_value", "arg1_id": "NCT02965027_exc_T47", "arg2_id": "NCT02965027_exc_T48", "normalized": [] }, { "id": "NCT02965027_exc_R28", "type": "Has_value", "arg1_id": "NCT02965027_exc_T50", "arg2_id": "NCT02965027_exc_T51", "normalized": [] }, { "id": "NCT02965027_exc_R29", "type": "Has_temporal", "arg1_id": "NCT02965027_exc_T50", "arg2_id": "NCT02965027_exc_T52", "normalized": [] }, { "id": "NCT02965027_exc_R30", "type": "Subsumes", "arg1_id": "NCT02965027_exc_T49", "arg2_id": "NCT02965027_exc_T63", "normalized": [] }, { "id": "NCT02965027_exc_R31", "type": "Has_qualifier", "arg1_id": "NCT02965027_exc_T58", "arg2_id": "NCT02965027_exc_T59", "normalized": [] }, { "id": "NCT02965027_exc_R32", "type": "Subsumes", "arg1_id": "NCT02965027_exc_T46", "arg2_id": "NCT02965027_exc_T47", "normalized": [] }, { "id": "NCT02965027_exc_R33", "type": "Subsumes", "arg1_id": "NCT02965027_exc_T65", "arg2_id": "NCT02965027_exc_T64", "normalized": [] }, { "id": "NCT02965027_exc_R34", "type": "Has_index", "arg1_id": "NCT02965027_exc_T74", "arg2_id": "NCT02965027_exc_T75", "normalized": [] }, { "id": "NCT02965027_exc_R35", "type": "Has_qualifier", "arg1_id": "NCT02965027_exc_T68", "arg2_id": "NCT02965027_exc_T67", "normalized": [] }, { "id": "NCT02965027_exc_R36", "type": "Subsumes", "arg1_id": "NCT02965027_exc_T76", "arg2_id": "NCT02965027_exc_T77", "normalized": [] }, { "id": "NCT02965027_exc_R37", "type": "Has_temporal", "arg1_id": "NCT02965027_exc_T76", "arg2_id": "NCT02965027_exc_T74", "normalized": [] }, { "id": "NCT02965027_exc_R38", "type": "Has_temporal", "arg1_id": "NCT02965027_exc_T79", "arg2_id": "NCT02965027_exc_T80", "normalized": [] }, { "id": "NCT02965027_exc_R39", "type": "Has_qualifier", "arg1_id": "NCT02965027_exc_T82", "arg2_id": "NCT02965027_exc_T83", "normalized": [] }, { "id": "NCT02965027_exc_R40", "type": "Has_scope", "arg1_id": "NCT02965027_exc_T85", "arg2_id": "NCT02965027_exc_T84", "normalized": [] }, { "id": "NCT02965027_exc_R41", "type": "Has_qualifier", "arg1_id": "NCT02965027_exc_T90", "arg2_id": "NCT02965027_exc_T91", "normalized": [] }, { "id": "NCT02965027_exc_R42", "type": "Has_qualifier", "arg1_id": "NCT02965027_exc_T92", "arg2_id": "NCT02965027_exc_T93", "normalized": [] }, { "id": "NCT02965027_exc_R43", "type": "Subsumes", "arg1_id": "NCT02965027_exc_T92", "arg2_id": "NCT02965027_exc_T96", "normalized": [] }, { "id": "NCT02965027_exc_R44", "type": "Has_qualifier", "arg1_id": "NCT02965027_exc_T87", "arg2_id": "NCT02965027_exc_T88", "normalized": [] }, { "id": "NCT02965027_exc_R45", "type": "Has_negation", "arg1_id": "NCT02965027_exc_T101", "arg2_id": "NCT02965027_exc_T99", "normalized": [] }, { "id": "NCT02965027_exc_R46", "type": "Has_scope", "arg1_id": "NCT02965027_exc_T97", "arg2_id": "NCT02965027_exc_T101", "normalized": [] }, { "id": "NCT02965027_exc_R47", "type": "Has_value", "arg1_id": "NCT02965027_exc_T102", "arg2_id": "NCT02965027_exc_T103", "normalized": [] }, { "id": "NCT02965027_exc_R48", "type": "AND", "arg1_id": "NCT02965027_exc_T97", "arg2_id": "NCT02965027_exc_T102", "normalized": [] }, { "id": "NCT02965027_exc_R49", "type": "Has_temporal", "arg1_id": "NCT02965027_exc_T104", "arg2_id": "NCT02965027_exc_T105", "normalized": [] }, { "id": "NCT02965027_exc_R50", "type": "Has_qualifier", "arg1_id": "NCT02965027_exc_T112", "arg2_id": "NCT02965027_exc_T114", "normalized": [] }, { "id": "NCT02965027_exc_R51", "type": "Has_temporal", "arg1_id": "NCT02965027_exc_T112", "arg2_id": "NCT02965027_exc_T113", "normalized": [] }, { "id": "NCT02965027_exc_R52", "type": "AND", "arg1_id": "NCT02965027_exc_T111", "arg2_id": "NCT02965027_exc_T112", "normalized": [] }, { "id": "NCT02965027_exc_R53", "type": "Has_qualifier", "arg1_id": "NCT02965027_exc_T116", "arg2_id": "NCT02965027_exc_T115", "normalized": [] }, { "id": "NCT02965027_exc_R54", "type": "AND", "arg1_id": "NCT02965027_exc_T111", "arg2_id": "NCT02965027_exc_T116", "normalized": [] }, { "id": "NCT02965027_exc_R55", "type": "Has_temporal", "arg1_id": "NCT02965027_exc_T117", "arg2_id": "NCT02965027_exc_T118", "normalized": [] }, { "id": "NCT02965027_exc_R56", "type": "Has_temporal", "arg1_id": "NCT02965027_exc_T126", "arg2_id": "NCT02965027_exc_T125", "normalized": [] }, { "id": "NCT02965027_exc_R57", "type": "Has_mood", "arg1_id": "NCT02965027_exc_T124", "arg2_id": "NCT02965027_exc_T123", "normalized": [] }, { "id": "NCT02965027_exc_R58", "type": "Has_negation", "arg1_id": "NCT02965027_exc_T127", "arg2_id": "NCT02965027_exc_T121", "normalized": [] }, { "id": "NCT02965027_exc_R59", "type": "Has_scope", "arg1_id": "NCT02965027_exc_T128", "arg2_id": "NCT02965027_exc_T127", "normalized": [] }, { "id": "NCT02965027_exc_R60", "type": "Has_multiplier", "arg1_id": "NCT02965027_exc_T133", "arg2_id": "NCT02965027_exc_T134", "normalized": [] }, { "id": "NCT02965027_exc_R61", "type": "Has_temporal", "arg1_id": "NCT02965027_exc_T133", "arg2_id": "NCT02965027_exc_T135", "normalized": [] }, { "id": "NCT02965027_exc_R62", "type": "Has_temporal", "arg1_id": "NCT02965027_exc_T141", "arg2_id": "NCT02965027_exc_T142", "normalized": [] }, { "id": "NCT02965027_exc_R63", "type": "Has_qualifier", "arg1_id": "NCT02965027_exc_T139", "arg2_id": "NCT02965027_exc_T143", "normalized": [] }, { "id": "NCT02965027_exc_R64", "type": "Has_multiplier", "arg1_id": "NCT02965027_exc_T139", "arg2_id": "NCT02965027_exc_T140", "normalized": [] }, { "id": "NCT02965027_exc_R65", "type": "Has_qualifier", "arg1_id": "NCT02965027_exc_T144", "arg2_id": "NCT02965027_exc_T141", "normalized": [] }, { "id": "NCT02965027_exc_R66", "type": "Has_temporal", "arg1_id": "NCT02965027_exc_T151", "arg2_id": "NCT02965027_exc_T152", "normalized": [] }, { "id": "NCT02965027_exc_R67", "type": "Subsumes", "arg1_id": "NCT02965027_exc_T154", "arg2_id": "NCT02965027_exc_T155", "normalized": [] }, { "id": "NCT02965027_exc_R68", "type": "Subsumes", "arg1_id": "NCT02965027_exc_T156", "arg2_id": "NCT02965027_exc_T157", "normalized": [] }, { "id": "NCT02965027_exc_R69", "type": "Subsumes", "arg1_id": "NCT02965027_exc_T158", "arg2_id": "NCT02965027_exc_T159", "normalized": [] }, { "id": "NCT02965027_exc_R70", "type": "Subsumes", "arg1_id": "NCT02965027_exc_T160", "arg2_id": "NCT02965027_exc_T161", "normalized": [] }, { "id": "NCT02965027_exc_R71", "type": "Has_temporal", "arg1_id": "NCT02965027_exc_T163", "arg2_id": "NCT02965027_exc_T162", "normalized": [] }, { "id": "NCT02965027_exc_R72", "type": "Subsumes", "arg1_id": "NCT02965027_exc_T165", "arg2_id": "NCT02965027_exc_T166", "normalized": [] }, { "id": "NCT02965027_exc_R73", "type": "Has_temporal", "arg1_id": "NCT02965027_exc_T168", "arg2_id": "NCT02965027_exc_T167", "normalized": [] }, { "id": "NCT02965027_exc_R74", "type": "Subsumes", "arg1_id": "NCT02965027_exc_T169", "arg2_id": "NCT02965027_exc_T172", "normalized": [] }, { "id": "NCT02965027_exc_R75", "type": "Has_temporal", "arg1_id": "NCT02965027_exc_T169", "arg2_id": "NCT02965027_exc_T173", "normalized": [] } ]

[ { "id": "NCT02965027_inc_text", "type": "inclusion", "text": [ "Male and female Active-duty SMs or Veterans aged 18 or older who are in good general health.\nHistory of blast and/or impact head trauma mTBI meeting Defense and Veterans Brain Injury Center (DVBIC) mTBI criteria, which define mTBI as an injury to the head causing at least one of the following: alteration in consciousness (for up to 24 hours after the injury), loss of consciousness 0-30 minutes, and/or post-traumatic amnesia up to 1 day post-injury. If available, the Glasgow Coma Scale score must be 13-15, and head imaging findings (if imaging was performed) must be negative.\nFrequent HAs that started within 3months after a head injury. The HAs either 1) must last 4 or more hours a day and reach a moderate to severe intensity at any point during the headache, or 2) may be of any severity or duration if the participant takes a triptan or ergotamine. HAs meeting these criteria must have been present on average at least 8 days per 4-week period, starting within 30 days after head injury and occurring by self-report for at least 3 months prior to the Initial Screening Visit. The 4-week HA frequency/severity criteria must be confirmed during the Preliminary Screening Period.\nWomen of childbearing potential must agree to abstain from sexual relations that could result in pregnancy or use an effective method of birth control acceptable to both participant and the clinician prescriber during the study. Men are not required to use contraception during the study.\nParticipants must have English fluency sufficient to complete study measures.\n" ], "offsets": [ [ 0, 1555 ] ] } ]

[ { "id": "NCT02965027_inc_T1", "type": "Person", "text": [ "Male" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T2", "type": "Person", "text": [ "female" ], "offsets": [ [ 9, 15 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T3", "type": "Person", "text": [ "Active-duty SMs" ], "offsets": [ [ 16, 31 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T4", "type": "Person", "text": [ "Veterans" ], "offsets": [ [ 35, 43 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T5", "type": "Value", "text": [ "18 or older" ], "offsets": [ [ 49, 60 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T6", "type": "Person", "text": [ "aged" ], "offsets": [ [ 44, 48 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T7", "type": "Condition", "text": [ "good general health" ], "offsets": [ [ 72, 91 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T8", "type": "Observation", "text": [ "blast" ], "offsets": [ [ 104, 109 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T9", "type": "Observation", "text": [ "History of" ], "offsets": [ [ 93, 103 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T10", "type": "Condition", "text": [ "impact head trauma" ], "offsets": [ [ 117, 135 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T11", "type": "Measurement", "text": [ "Defense and Veterans Brain Injury Center (DVBIC) mTBI criteria" ], "offsets": [ [ 149, 211 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T12", "type": "Value", "text": [ "meeting" ], "offsets": [ [ 141, 148 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T13", "type": "Condition", "text": [ "alteration in consciousness" ], "offsets": [ [ 295, 322 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T14", "type": "Temporal", "text": [ "for up to 24 hours after the injury" ], "offsets": [ [ 324, 359 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T15", "type": "Reference_point", "text": [ "the injury" ], "offsets": [ [ 349, 359 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T16", "type": "Condition", "text": [ "loss of consciousness" ], "offsets": [ [ 362, 383 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T17", "type": "Temporal", "text": [ "0-30 minutes" ], "offsets": [ [ 384, 396 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T18", "type": "Condition", "text": [ "post-traumatic amnesia" ], "offsets": [ [ 405, 427 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T19", "type": "Temporal", "text": [ "up to 1 day post-injury" ], "offsets": [ [ 428, 451 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T20", "type": "Measurement", "text": [ "Glasgow Coma Scale" ], "offsets": [ [ 471, 489 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T21", "type": "Value", "text": [ "13-15" ], "offsets": [ [ 504, 509 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T22", "type": "Procedure", "text": [ "head imaging" ], "offsets": [ [ 515, 527 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T23", "type": "Condition", "text": [ "findings" ], "offsets": [ [ 528, 536 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T24", "type": "Negation", "text": [ "negative" ], "offsets": [ [ 572, 580 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T25", "type": "Scope", "text": [ "alteration in consciousness (for up to 24 hours after the injury), loss of consciousness 0-30 minutes, and/or post-traumatic amnesia up to 1 day post-injury" ], "offsets": [ [ 295, 451 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T26", "type": "Condition", "text": [ "HAs" ], "offsets": [ [ 591, 594 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T27", "type": "Qualifier", "text": [ "Frequent" ], "offsets": [ [ 582, 590 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T28", "type": "Temporal", "text": [ "within 3months after a head injury" ], "offsets": [ [ 608, 642 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T29", "type": "Reference_point", "text": [ "a head injury" ], "offsets": [ [ 629, 642 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T30", "type": "Condition", "text": [ "HAs" ], "offsets": [ [ 648, 651 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T31", "type": "Multiplier", "text": [ "last 4 or more hours a day" ], "offsets": [ [ 667, 693 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T32", "type": "Qualifier", "text": [ "moderate to severe intensity" ], "offsets": [ [ 706, 734 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T33", "type": "Drug", "text": [ "triptan" ], "offsets": [ [ 837, 844 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T34", "type": "Drug", "text": [ "ergotamine" ], "offsets": [ [ 848, 858 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T35", "type": "Multiplier", "text": [ "at least 8 days per 4-week period" ], "offsets": [ [ 921, 954 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T36", "type": "Temporal", "text": [ "within 30 days after head injury" ], "offsets": [ [ 965, 997 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T37", "type": "Temporal", "text": [ "at least 3 months prior to the Initial Screening Visit" ], "offsets": [ [ 1031, 1085 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T38", "type": "Reference_point", "text": [ "the Initial Screening Visit" ], "offsets": [ [ 1058, 1085 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T39", "type": "Scope", "text": [ "last 4 or more hours a day and reach a moderate to severe intensity" ], "offsets": [ [ 667, 734 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T40", "type": "Scope", "text": [ "triptan or ergotamine" ], "offsets": [ [ 837, 858 ] ], "normalized": [] }, { "id": "NCT02965027_inc_T41", "type": "Scope", "text": [ "last 4 or more hours a day and reach a moderate to severe intensity at any point during the headache, or 2) may be of any severity or duration if the participant takes a triptan or ergotamine" ], "offsets": [ [ 667, 858 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02965027_inc_R1", "type": "Has_value", "arg1_id": "NCT02965027_inc_T6", "arg2_id": "NCT02965027_inc_T5", "normalized": [] }, { "id": "NCT02965027_inc_R3", "type": "Has_temporal", "arg1_id": "NCT02965027_inc_T10", "arg2_id": "NCT02965027_inc_T9", "normalized": [] }, { "id": "NCT02965027_inc_R4", "type": "Has_value", "arg1_id": "NCT02965027_inc_T11", "arg2_id": "NCT02965027_inc_T12", "normalized": [] }, { "id": "NCT02965027_inc_R5", "type": "AND", "arg1_id": "NCT02965027_inc_T10", "arg2_id": "NCT02965027_inc_T11", "normalized": [] }, { "id": "NCT02965027_inc_R6", "type": "Has_index", "arg1_id": "NCT02965027_inc_T14", "arg2_id": "NCT02965027_inc_T15", "normalized": [] }, { "id": "NCT02965027_inc_R7", "type": "Has_temporal", "arg1_id": "NCT02965027_inc_T16", "arg2_id": "NCT02965027_inc_T17", "normalized": [] }, { "id": "NCT02965027_inc_R8", "type": "Has_temporal", "arg1_id": "NCT02965027_inc_T13", "arg2_id": "NCT02965027_inc_T14", "normalized": [] }, { "id": "NCT02965027_inc_R9", "type": "Has_temporal", "arg1_id": "NCT02965027_inc_T18", "arg2_id": "NCT02965027_inc_T19", "normalized": [] }, { "id": "NCT02965027_inc_R10", "type": "Has_negation", "arg1_id": "NCT02965027_inc_T23", "arg2_id": "NCT02965027_inc_T24", "normalized": [] }, { "id": "NCT02965027_inc_R11", "type": "AND", "arg1_id": "NCT02965027_inc_T22", "arg2_id": "NCT02965027_inc_T23", "normalized": [] }, { "id": "NCT02965027_inc_R12", "type": "Has_value", "arg1_id": "NCT02965027_inc_T20", "arg2_id": "NCT02965027_inc_T21", "normalized": [] }, { "id": "NCT02965027_inc_R13", "type": "Subsumes", "arg1_id": "NCT02965027_inc_T11", "arg2_id": "NCT02965027_inc_T25", "normalized": [] }, { "id": "NCT02965027_inc_R14", "type": "Has_qualifier", "arg1_id": "NCT02965027_inc_T26", "arg2_id": "NCT02965027_inc_T27", "normalized": [] }, { "id": "NCT02965027_inc_R15", "type": "Has_index", "arg1_id": "NCT02965027_inc_T28", "arg2_id": "NCT02965027_inc_T29", "normalized": [] }, { "id": "NCT02965027_inc_R16", "type": "Has_temporal", "arg1_id": "NCT02965027_inc_T26", "arg2_id": "NCT02965027_inc_T28", "normalized": [] }, { "id": "NCT02965027_inc_R17", "type": "Has_index", "arg1_id": "NCT02965027_inc_T37", "arg2_id": "NCT02965027_inc_T38", "normalized": [] }, { "id": "NCT02965027_inc_R18", "type": "Has_scope", "arg1_id": "NCT02965027_inc_T30", "arg2_id": "NCT02965027_inc_T41", "normalized": [] }, { "id": "NCT02965027_inc_R19", "type": "Has_multiplier", "arg1_id": "NCT02965027_inc_T30", "arg2_id": "NCT02965027_inc_T35", "normalized": [] }, { "id": "NCT02965027_inc_R20", "type": "Has_temporal", "arg1_id": "NCT02965027_inc_T30", "arg2_id": "NCT02965027_inc_T36", "normalized": [] }, { "id": "NCT02965027_inc_R21", "type": "Has_temporal", "arg1_id": "NCT02965027_inc_T30", "arg2_id": "NCT02965027_inc_T37", "normalized": [] } ]

[ { "id": "NCT02965443_exc_text", "type": "exclusion", "text": [ "Use of any oral antidiabetic treatment except for metformin (i.e., sulphonylureas, DPP-IV inhibitors, thiazolidinediones, SGLT-2 inhibitors (Sodium dependent glucose transporter) or GLP-1 analogues (glucagone like peptide) within the last three months prior to Screening\nRepeated episodes of severe hypoglycaemia within the last six months prior to Screening\nHistory of diabetic ketoacidosis, precoma diabetica, or diabetic coma\nTreatment with any other investigational drug within the last three months before Screening\nAcute infections within the last four weeks prior to Screening\nRecurrent urogenital infections\nHistory of pancreatitis\nAnamnestic history of hypersensitivity to the study drugs or to drugs with similar chemical structures\nHistory of severe or multiple allergies\nConcomitant participation in other clinical trials\nType 1 diabetes\nCardiovascular disease Clinically relevant ventricular tachycardia or ventricular fibrillation, 3rd degree AV block or Torsades de Pointes or treatment with antiarrhythmic drugs. Percutaneous coronary intervention within the past 6 months. Any of the following within the past 6 months: myocardial infarction (MI), coronary artery bypass surgery; unstable angina; or stroke.\nMalignancy including leukemia and lymphoma within the last 5y.\nLiver disease such as cirrhosis or chronic active hepatitis.\nSignificant renal dysfunction (see also exclusion criteria laboratory abnormalities).\nState after kidney transplantation\nEndocrine disease:\nSystolic blood pressure outside the range of 100-160 mmHg or diastolic blood pressure above 95 mmHg at Screening\nHistory of active substance abuse (including alcohol > 40g/day) within the past 2 years.\nPregnancy or childbearing potential without adequate contraception\nPresent therapy with systemic steroids\nPresence of psychiatric disorder or intake of anti-depressive or anti-psychotic agents with the exception of benzodiazepines and SSRIs/SNRI's (selective serotonin reuptake inhibitor)\nPotentially unreliable subjects, and those judged by the investigator to be unsuitable for the study.\nContraindications for Magnetic resonance (MR) scanning such as persons with cardiac pacemaker and implants out of metal or claustrophobia\n" ], "offsets": [ [ 0, 2220 ] ] } ]

[ { "id": "NCT02965443_exc_T1", "type": "Procedure", "text": [ "oral antidiabetic treatment" ], "offsets": [ [ 11, 38 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T2", "type": "Drug", "text": [ "oral antidiabetic" ], "offsets": [ [ 11, 28 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T3", "type": "Negation", "text": [ "except for" ], "offsets": [ [ 39, 49 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T4", "type": "Drug", "text": [ "metformin" ], "offsets": [ [ 50, 59 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T5", "type": "Drug", "text": [ "sulphonylureas" ], "offsets": [ [ 67, 81 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T6", "type": "Drug", "text": [ "DPP-IV inhibitors" ], "offsets": [ [ 83, 100 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T7", "type": "Drug", "text": [ "thiazolidinediones" ], "offsets": [ [ 102, 120 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T8", "type": "Drug", "text": [ "SGLT-2 inhibitors" ], "offsets": [ [ 122, 139 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T9", "type": "Drug", "text": [ "GLP-1 analogues" ], "offsets": [ [ 182, 197 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T10", "type": "Temporal", "text": [ "within the last three months prior to Screening" ], "offsets": [ [ 223, 270 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T11", "type": "Reference_point", "text": [ "Screening" ], "offsets": [ [ 261, 270 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T12", "type": "Scope", "text": [ "sulphonylureas, DPP-IV inhibitors, thiazolidinediones, SGLT-2 inhibitors (Sodium dependent glucose transporter) or GLP-1 analogues (glucagone like peptide)" ], "offsets": [ [ 67, 222 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T13", "type": "Scope", "text": [ "oral antidiabetic treatment except for metformin" ], "offsets": [ [ 11, 59 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T14", "type": "Multiplier", "text": [ "Repeated" ], "offsets": [ [ 271, 279 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T15", "type": "Condition", "text": [ "severe hypoglycaemia" ], "offsets": [ [ 292, 312 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T16", "type": "Temporal", "text": [ "within the last six months prior to Screening" ], "offsets": [ [ 313, 358 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T17", "type": "Reference_point", "text": [ "Screening" ], "offsets": [ [ 349, 358 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T18", "type": "Condition", "text": [ "diabetic ketoacidosis" ], "offsets": [ [ 370, 391 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T19", "type": "Observation", "text": [ "History" ], "offsets": [ [ 359, 366 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T20", "type": "Condition", "text": [ "precoma diabetica" ], "offsets": [ [ 393, 410 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T21", "type": "Condition", "text": [ "diabetic coma" ], "offsets": [ [ 415, 428 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T22", "type": "Scope", "text": [ "diabetic ketoacidosis, precoma diabetica, or diabetic coma" ], "offsets": [ [ 370, 428 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T23", "type": "Drug", "text": [ "investigational drug" ], "offsets": [ [ 454, 474 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T24", "type": "Procedure", "text": [ "Treatment" ], "offsets": [ [ 429, 438 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T25", "type": "Temporal", "text": [ "within the last three months before Screening" ], "offsets": [ [ 475, 520 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T26", "type": "Reference_point", "text": [ "Screening" ], "offsets": [ [ 511, 520 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T27", "type": "Condition", "text": [ "Acute infections" ], "offsets": [ [ 521, 537 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T28", "type": "Temporal", "text": [ "within the last four weeks prior to Screening" ], "offsets": [ [ 538, 583 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T29", "type": "Reference_point", "text": [ "Screening" ], "offsets": [ [ 574, 583 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T30", "type": "Multiplier", "text": [ "Recurrent" ], "offsets": [ [ 584, 593 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T31", "type": "Condition", "text": [ "urogenital infections" ], "offsets": [ [ 594, 615 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T32", "type": "Observation", "text": [ "History" ], "offsets": [ [ 616, 623 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T33", "type": "Condition", "text": [ "pancreatitis" ], "offsets": [ [ 627, 639 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T34", "type": "Observation", "text": [ "Anamnestic history" ], "offsets": [ [ 640, 658 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T35", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 662, 678 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T36", "type": "Drug", "text": [ "study drugs" ], "offsets": [ [ 686, 697 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T37", "type": "Drug", "text": [ "drugs with similar chemical structures" ], "offsets": [ [ 704, 742 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T38", "type": "Scope", "text": [ "study drugs or to drugs with similar chemical structures" ], "offsets": [ [ 686, 742 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T39", "type": "Condition", "text": [ "allergies" ], "offsets": [ [ 773, 782 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T40", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 754, 760 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T41", "type": "Qualifier", "text": [ "multiple" ], "offsets": [ [ 764, 772 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T42", "type": "Scope", "text": [ "severe or multiple" ], "offsets": [ [ 754, 772 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T43", "type": "Observation", "text": [ "History" ], "offsets": [ [ 743, 750 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T44", "type": "Temporal", "text": [ "Concomitant" ], "offsets": [ [ 783, 794 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T45", "type": "Observation", "text": [ "participation in other clinical trials" ], "offsets": [ [ 795, 833 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T46", "type": "Condition", "text": [ "Type 1 diabetes" ], "offsets": [ [ 834, 849 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T47", "type": "Condition", "text": [ "Cardiovascular disease" ], "offsets": [ [ 850, 872 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T48", "type": "Qualifier", "text": [ "Clinically relevant" ], "offsets": [ [ 873, 892 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T49", "type": "Condition", "text": [ "ventricular tachycardia" ], "offsets": [ [ 893, 916 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T50", "type": "Condition", "text": [ "ventricular fibrillation" ], "offsets": [ [ 920, 944 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T51", "type": "Condition", "text": [ "3rd degree AV block" ], "offsets": [ [ 946, 965 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T52", "type": "Condition", "text": [ "Torsades de Pointes" ], "offsets": [ [ 969, 988 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T53", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 992, 1001 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T54", "type": "Drug", "text": [ "antiarrhythmic drugs" ], "offsets": [ [ 1007, 1027 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T55", "type": "Procedure", "text": [ "Percutaneous coronary intervention" ], "offsets": [ [ 1029, 1063 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T56", "type": "Temporal", "text": [ "within the past 6 months" ], "offsets": [ [ 1064, 1088 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T57", "type": "Scope", "text": [ "ventricular tachycardia or ventricular fibrillation, 3rd degree AV block or Torsades de Pointes or treatment with antiarrhythmic drugs" ], "offsets": [ [ 893, 1027 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T58", "type": "Temporal", "text": [ "within the past 6 months" ], "offsets": [ [ 1111, 1135 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T59", "type": "Condition", "text": [ "myocardial infarction (MI)" ], "offsets": [ [ 1137, 1163 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T60", "type": "Procedure", "text": [ "coronary artery bypass surgery" ], "offsets": [ [ 1165, 1195 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T61", "type": "Condition", "text": [ "unstable angina" ], "offsets": [ [ 1197, 1212 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T62", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 1217, 1223 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T63", "type": "Scope", "text": [ "myocardial infarction (MI), coronary artery bypass surgery; unstable angina; or stroke" ], "offsets": [ [ 1137, 1223 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T64", "type": "Scope", "text": [ "Clinically relevant ventricular tachycardia or ventricular fibrillation, 3rd degree AV block or Torsades de Pointes or treatment with antiarrhythmic drugs. Percutaneous coronary intervention within the past 6 months. Any of the following within the past 6 months: myocardial infarction (MI), coronary artery bypass surgery; unstable angina; or stroke" ], "offsets": [ [ 873, 1223 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T65", "type": "Condition", "text": [ "Malignancy" ], "offsets": [ [ 1225, 1235 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T66", "type": "Condition", "text": [ "leukemia" ], "offsets": [ [ 1246, 1254 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T67", "type": "Condition", "text": [ "lymphoma" ], "offsets": [ [ 1259, 1267 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T68", "type": "Temporal", "text": [ "within the last 5y" ], "offsets": [ [ 1268, 1286 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T69", "type": "Scope", "text": [ "leukemia and lymphoma" ], "offsets": [ [ 1246, 1267 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T70", "type": "Condition", "text": [ "Liver disease" ], "offsets": [ [ 1288, 1301 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T71", "type": "Condition", "text": [ "cirrhosis" ], "offsets": [ [ 1310, 1319 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T72", "type": "Condition", "text": [ "chronic active hepatitis" ], "offsets": [ [ 1323, 1347 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T73", "type": "Scope", "text": [ "cirrhosis or chronic active hepatitis" ], "offsets": [ [ 1310, 1347 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T74", "type": "Qualifier", "text": [ "Significant" ], "offsets": [ [ 1349, 1360 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T75", "type": "Condition", "text": [ "renal dysfunction" ], "offsets": [ [ 1361, 1378 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T77", "type": "Condition", "text": [ "State after kidney transplantation" ], "offsets": [ [ 1435, 1469 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T78", "type": "Procedure", "text": [ "kidney transplantation" ], "offsets": [ [ 1447, 1469 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T79", "type": "Condition", "text": [ "Endocrine disease" ], "offsets": [ [ 1470, 1487 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T80", "type": "Measurement", "text": [ "Systolic blood pressure" ], "offsets": [ [ 1489, 1512 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T81", "type": "Value", "text": [ "outside the range of 100-160 mmHg" ], "offsets": [ [ 1513, 1546 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T82", "type": "Measurement", "text": [ "diastolic blood pressure" ], "offsets": [ [ 1550, 1574 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T83", "type": "Value", "text": [ "above 95 mmHg" ], "offsets": [ [ 1575, 1588 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T84", "type": "Temporal", "text": [ "at Screening" ], "offsets": [ [ 1589, 1601 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T85", "type": "Scope", "text": [ "Systolic blood pressure outside the range of 100-160 mmHg or diastolic blood pressure above 95 mmHg" ], "offsets": [ [ 1489, 1588 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T87", "type": "Observation", "text": [ "History" ], "offsets": [ [ 1602, 1609 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T88", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 1613, 1619 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T89", "type": "Condition", "text": [ "substance abuse" ], "offsets": [ [ 1620, 1635 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T90", "type": "Measurement", "text": [ "alcohol" ], "offsets": [ [ 1647, 1654 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T91", "type": "Value", "text": [ "> 40g/day" ], "offsets": [ [ 1655, 1664 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T92", "type": "Scope", "text": [ "alcohol > 40g/day" ], "offsets": [ [ 1647, 1664 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T93", "type": "Temporal", "text": [ "within the past 2 years" ], "offsets": [ [ 1666, 1689 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T94", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 1691, 1700 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T95", "type": "Observation", "text": [ "childbearing potential" ], "offsets": [ [ 1704, 1726 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T96", "type": "Negation", "text": [ "without" ], "offsets": [ [ 1727, 1734 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T97", "type": "Qualifier", "text": [ "adequate" ], "offsets": [ [ 1735, 1743 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T98", "type": "Procedure", "text": [ "contraception" ], "offsets": [ [ 1744, 1757 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T99", "type": "Procedure", "text": [ "therapy" ], "offsets": [ [ 1766, 1773 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T100", "type": "Temporal", "text": [ "Present" ], "offsets": [ [ 1758, 1765 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T101", "type": "Drug", "text": [ "systemic steroids" ], "offsets": [ [ 1779, 1796 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T102", "type": "Condition", "text": [ "psychiatric disorder" ], "offsets": [ [ 1809, 1829 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T103", "type": "Drug", "text": [ "ti-psychotic ag", "tion o" ], "offsets": [ [ 1864, 1879 ], [ 1898, 1904 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T104", "type": "Drug", "text": [ "anti-psychotic agents" ], "offsets": [ [ 1862, 1883 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T105", "type": "Negation", "text": [ "with the exception of" ], "offsets": [ [ 1884, 1905 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T106", "type": "Drug", "text": [ "benzodiazepines" ], "offsets": [ [ 1906, 1921 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T107", "type": "Drug", "text": [ "SSRIs" ], "offsets": [ [ 1926, 1931 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T108", "type": "Drug", "text": [ "SNRI's" ], "offsets": [ [ 1932, 1938 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T109", "type": "Scope", "text": [ "benzodiazepines and SSRIs/SNRI's" ], "offsets": [ [ 1906, 1938 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T110", "type": "Scope", "text": [ "anti-depressive or anti-psychotic agents" ], "offsets": [ [ 1843, 1883 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T111", "type": "Scope", "text": [ "anti-depressive or anti-psychotic agents with the exception of benzodiazepines and SSRIs/SNRI's" ], "offsets": [ [ 1843, 1938 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T112", "type": "Observation", "text": [ "unreliable subjects" ], "offsets": [ [ 1992, 2011 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T114", "type": "Observation", "text": [ "unsuitable for the study" ], "offsets": [ [ 2056, 2080 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T116", "type": "Condition", "text": [ "Contraindications" ], "offsets": [ [ 2082, 2099 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T117", "type": "Procedure", "text": [ "Magnetic resonance (MR) scanning" ], "offsets": [ [ 2104, 2136 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T118", "type": "Device", "text": [ "cardiac pacemaker" ], "offsets": [ [ 2158, 2175 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T119", "type": "Device", "text": [ "implants out of metal" ], "offsets": [ [ 2180, 2201 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T120", "type": "Condition", "text": [ "claustrophobia" ], "offsets": [ [ 2205, 2219 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T121", "type": "Scope", "text": [ "Contraindications for Magnetic resonance (MR) scanning" ], "offsets": [ [ 2082, 2136 ] ], "normalized": [] }, { "id": "NCT02965443_exc_T122", "type": "Scope", "text": [ "cardiac pacemaker and implants out of metal or claustrophobia" ], "offsets": [ [ 2158, 2219 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02965443_exc_R2", "type": "Has_negation", "arg1_id": "NCT02965443_exc_T4", "arg2_id": "NCT02965443_exc_T3", "normalized": [] }, { "id": "NCT02965443_exc_R3", "type": "AND", "arg1_id": "NCT02965443_exc_T1", "arg2_id": "NCT02965443_exc_T4", "normalized": [] }, { "id": "NCT02965443_exc_R4", "type": "Has_index", "arg1_id": "NCT02965443_exc_T10", "arg2_id": "NCT02965443_exc_T11", "normalized": [] }, { "id": "NCT02965443_exc_R5", "type": "Subsumes", "arg1_id": "NCT02965443_exc_T13", "arg2_id": "NCT02965443_exc_T12", "normalized": [] }, { "id": "NCT02965443_exc_R6", "type": "Has_temporal", "arg1_id": "NCT02965443_exc_T13", "arg2_id": "NCT02965443_exc_T10", "normalized": [] }, { "id": "NCT02965443_exc_R7", "type": "Has_index", "arg1_id": "NCT02965443_exc_T16", "arg2_id": "NCT02965443_exc_T17", "normalized": [] }, { "id": "NCT02965443_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02965443_exc_T15", "arg2_id": "NCT02965443_exc_T16", "normalized": [] }, { "id": "NCT02965443_exc_R9", "type": "Has_multiplier", "arg1_id": "NCT02965443_exc_T15", "arg2_id": "NCT02965443_exc_T14", "normalized": [] }, { "id": "NCT02965443_exc_R10", "type": "Has_temporal", "arg1_id": "NCT02965443_exc_T22", "arg2_id": "NCT02965443_exc_T19", "normalized": [] }, { "id": "NCT02965443_exc_R11", "type": "AND", "arg1_id": "NCT02965443_exc_T24", "arg2_id": "NCT02965443_exc_T23", "normalized": [] }, { "id": "NCT02965443_exc_R12", "type": "Has_index", "arg1_id": "NCT02965443_exc_T25", "arg2_id": "NCT02965443_exc_T26", "normalized": [] }, { "id": "NCT02965443_exc_R13", "type": "Has_temporal", "arg1_id": "NCT02965443_exc_T24", "arg2_id": "NCT02965443_exc_T25", "normalized": [] }, { "id": "NCT02965443_exc_R14", "type": "Has_index", "arg1_id": "NCT02965443_exc_T28", "arg2_id": "NCT02965443_exc_T29", "normalized": [] }, { "id": "NCT02965443_exc_R15", "type": "Has_temporal", "arg1_id": "NCT02965443_exc_T27", "arg2_id": "NCT02965443_exc_T28", "normalized": [] }, { "id": "NCT02965443_exc_R16", "type": "Has_multiplier", "arg1_id": "NCT02965443_exc_T31", "arg2_id": "NCT02965443_exc_T30", "normalized": [] }, { "id": "NCT02965443_exc_R17", "type": "Has_temporal", "arg1_id": "NCT02965443_exc_T33", "arg2_id": "NCT02965443_exc_T32", "normalized": [] }, { "id": "NCT02965443_exc_R18", "type": "Has_scope", "arg1_id": "NCT02965443_exc_T35", "arg2_id": "NCT02965443_exc_T38", "normalized": [] }, { "id": "NCT02965443_exc_R19", "type": "Has_temporal", "arg1_id": "NCT02965443_exc_T35", "arg2_id": "NCT02965443_exc_T34", "normalized": [] }, { "id": "NCT02965443_exc_R20", "type": "Has_scope", "arg1_id": "NCT02965443_exc_T39", "arg2_id": "NCT02965443_exc_T42", "normalized": [] }, { "id": "NCT02965443_exc_R21", "type": "Has_temporal", "arg1_id": "NCT02965443_exc_T39", "arg2_id": "NCT02965443_exc_T43", "normalized": [] }, { "id": "NCT02965443_exc_R22", "type": "Has_temporal", "arg1_id": "NCT02965443_exc_T45", "arg2_id": "NCT02965443_exc_T44", "normalized": [] }, { "id": "NCT02965443_exc_R23", "type": "AND", "arg1_id": "NCT02965443_exc_T53", "arg2_id": "NCT02965443_exc_T54", "normalized": [] }, { "id": "NCT02965443_exc_R24", "type": "Has_temporal", "arg1_id": "NCT02965443_exc_T55", "arg2_id": "NCT02965443_exc_T56", "normalized": [] }, { "id": "NCT02965443_exc_R25", "type": "Has_qualifier", "arg1_id": "NCT02965443_exc_T57", "arg2_id": "NCT02965443_exc_T48", "normalized": [] }, { "id": "NCT02965443_exc_R26", "type": "Has_temporal", "arg1_id": "NCT02965443_exc_T63", "arg2_id": "NCT02965443_exc_T58", "normalized": [] }, { "id": "NCT02965443_exc_R27", "type": "Subsumes", "arg1_id": "NCT02965443_exc_T47", "arg2_id": "NCT02965443_exc_T64", "normalized": [] }, { "id": "NCT02965443_exc_R28", "type": "Subsumes", "arg1_id": "NCT02965443_exc_T65", "arg2_id": "NCT02965443_exc_T69", "normalized": [] }, { "id": "NCT02965443_exc_R29", "type": "Has_temporal", "arg1_id": "NCT02965443_exc_T65", "arg2_id": "NCT02965443_exc_T68", "normalized": [] }, { "id": "NCT02965443_exc_R30", "type": "Subsumes", "arg1_id": "NCT02965443_exc_T70", "arg2_id": "NCT02965443_exc_T73", "normalized": [] }, { "id": "NCT02965443_exc_R31", "type": "Has_qualifier", "arg1_id": "NCT02965443_exc_T75", "arg2_id": "NCT02965443_exc_T74", "normalized": [] }, { "id": "NCT02965443_exc_R33", "type": "Has_value", "arg1_id": "NCT02965443_exc_T80", "arg2_id": "NCT02965443_exc_T81", "normalized": [] }, { "id": "NCT02965443_exc_R34", "type": "Has_value", "arg1_id": "NCT02965443_exc_T82", "arg2_id": "NCT02965443_exc_T83", "normalized": [] }, { "id": "NCT02965443_exc_R35", "type": "Has_temporal", "arg1_id": "NCT02965443_exc_T85", "arg2_id": "NCT02965443_exc_T84", "normalized": [] }, { "id": "NCT02965443_exc_R36", "type": "Has_qualifier", "arg1_id": "NCT02965443_exc_T89", "arg2_id": "NCT02965443_exc_T88", "normalized": [] }, { "id": "NCT02965443_exc_R37", "type": "Has_temporal", "arg1_id": "NCT02965443_exc_T89", "arg2_id": "NCT02965443_exc_T87", "normalized": [] }, { "id": "NCT02965443_exc_R38", "type": "Has_value", "arg1_id": "NCT02965443_exc_T90", "arg2_id": "NCT02965443_exc_T91", "normalized": [] }, { "id": "NCT02965443_exc_R39", "type": "Subsumes", "arg1_id": "NCT02965443_exc_T89", "arg2_id": "NCT02965443_exc_T92", "normalized": [] }, { "id": "NCT02965443_exc_R40", "type": "Has_temporal", "arg1_id": "NCT02965443_exc_T89", "arg2_id": "NCT02965443_exc_T93", "normalized": [] }, { "id": "NCT02965443_exc_R41", "type": "Has_qualifier", "arg1_id": "NCT02965443_exc_T98", "arg2_id": "NCT02965443_exc_T97", "normalized": [] }, { "id": "NCT02965443_exc_R42", "type": "Has_negation", "arg1_id": "NCT02965443_exc_T98", "arg2_id": "NCT02965443_exc_T96", "normalized": [] }, { "id": "NCT02965443_exc_R43", "type": "Has_temporal", "arg1_id": "NCT02965443_exc_T99", "arg2_id": "NCT02965443_exc_T100", "normalized": [] }, { "id": "NCT02965443_exc_R44", "type": "AND", "arg1_id": "NCT02965443_exc_T99", "arg2_id": "NCT02965443_exc_T101", "normalized": [] }, { "id": "NCT02965443_exc_R45", "type": "Has_negation", "arg1_id": "NCT02965443_exc_T109", "arg2_id": "NCT02965443_exc_T105", "normalized": [] }, { "id": "NCT02965443_exc_R46", "type": "Has_scope", "arg1_id": "NCT02965443_exc_T110", "arg2_id": "NCT02965443_exc_T109", "normalized": [] }, { "id": "NCT02965443_exc_R47", "type": "Has_scope", "arg1_id": "NCT02965443_exc_T102", "arg2_id": "NCT02965443_exc_T111", "normalized": [] }, { "id": "NCT02965443_exc_R48", "type": "AND", "arg1_id": "NCT02965443_exc_T116", "arg2_id": "NCT02965443_exc_T117", "normalized": [] }, { "id": "NCT02965443_exc_R49", "type": "Subsumes", "arg1_id": "NCT02965443_exc_T121", "arg2_id": "NCT02965443_exc_T122", "normalized": [] } ]

[ { "id": "NCT02965443_inc_text", "type": "inclusion", "text": [ "Type 2 diabetes\nAge 18 - 75 years\nAnti-GAD antibodies negative (Glutamic Acid Decarboxylase)\nC-peptide levels = 1.5 ng/mL\nFasting blood glucose > 126 mg/dl\nHbA1c 8.0 - 10.5 %\nBMI 25.0 - 45.0 kg/m2\nPrevious therapy with BBIT (basal insulin and at least once daily bolus insulin)\n" ], "offsets": [ [ 0, 278 ] ] } ]

[ { "id": "NCT02965443_inc_T1", "type": "Condition", "text": [ "Type 2 diabetes" ], "offsets": [ [ 0, 15 ] ], "normalized": [] }, { "id": "NCT02965443_inc_T2", "type": "Person", "text": [ "Age" ], "offsets": [ [ 16, 19 ] ], "normalized": [] }, { "id": "NCT02965443_inc_T3", "type": "Value", "text": [ "18 - 75 years" ], "offsets": [ [ 20, 33 ] ], "normalized": [] }, { "id": "NCT02965443_inc_T4", "type": "Measurement", "text": [ "ti-GAD antibodies n", "lutamic Acid Decarboxylase)\nC" ], "offsets": [ [ 36, 55 ], [ 65, 94 ] ], "normalized": [] }, { "id": "NCT02965443_inc_T5", "type": "Value", "text": [ "negative" ], "offsets": [ [ 54, 62 ] ], "normalized": [] }, { "id": "NCT02965443_inc_T6", "type": "Measurement", "text": [ "C-peptide levels" ], "offsets": [ [ 93, 109 ] ], "normalized": [] }, { "id": "NCT02965443_inc_T7", "type": "Value", "text": [ "= 1.5 ng/mL" ], "offsets": [ [ 110, 121 ] ], "normalized": [] }, { "id": "NCT02965443_inc_T8", "type": "Measurement", "text": [ "Fasting blood glucose" ], "offsets": [ [ 122, 143 ] ], "normalized": [] }, { "id": "NCT02965443_inc_T9", "type": "Value", "text": [ "> 126 mg/dl" ], "offsets": [ [ 144, 155 ] ], "normalized": [] }, { "id": "NCT02965443_inc_T10", "type": "Measurement", "text": [ "HbA1c" ], "offsets": [ [ 156, 161 ] ], "normalized": [] }, { "id": "NCT02965443_inc_T11", "type": "Value", "text": [ "8.0 - 10.5 %" ], "offsets": [ [ 162, 174 ] ], "normalized": [] }, { "id": "NCT02965443_inc_T12", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 175, 178 ] ], "normalized": [] }, { "id": "NCT02965443_inc_T13", "type": "Temporal", "text": [ "Previous" ], "offsets": [ [ 197, 205 ] ], "normalized": [] }, { "id": "NCT02965443_inc_T14", "type": "Procedure", "text": [ "therapy" ], "offsets": [ [ 206, 213 ] ], "normalized": [] }, { "id": "NCT02965443_inc_T15", "type": "Drug", "text": [ "BBIT" ], "offsets": [ [ 219, 223 ] ], "normalized": [] }, { "id": "NCT02965443_inc_T16", "type": "Drug", "text": [ "basal insulin and at least once daily bolus insulin" ], "offsets": [ [ 225, 276 ] ], "normalized": [] }, { "id": "NCT02965443_inc_T17", "type": "Value", "text": [ "25.0 - 45.0 kg/m2" ], "offsets": [ [ 179, 196 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02965443_inc_R1", "type": "Has_value", "arg1_id": "NCT02965443_inc_T2", "arg2_id": "NCT02965443_inc_T3", "normalized": [] }, { "id": "NCT02965443_inc_R2", "type": "Has_value", "arg1_id": "NCT02965443_inc_T4", "arg2_id": "NCT02965443_inc_T5", "normalized": [] }, { "id": "NCT02965443_inc_R3", "type": "Has_value", "arg1_id": "NCT02965443_inc_T6", "arg2_id": "NCT02965443_inc_T7", "normalized": [] }, { "id": "NCT02965443_inc_R4", "type": "Has_value", "arg1_id": "NCT02965443_inc_T8", "arg2_id": "NCT02965443_inc_T9", "normalized": [] }, { "id": "NCT02965443_inc_R5", "type": "Has_value", "arg1_id": "NCT02965443_inc_T10", "arg2_id": "NCT02965443_inc_T11", "normalized": [] }, { "id": "NCT02965443_inc_R6", "type": "Subsumes", "arg1_id": "NCT02965443_inc_T15", "arg2_id": "NCT02965443_inc_T16", "normalized": [] }, { "id": "NCT02965443_inc_R7", "type": "AND", "arg1_id": "NCT02965443_inc_T14", "arg2_id": "NCT02965443_inc_T15", "normalized": [] }, { "id": "NCT02965443_inc_R8", "type": "Has_temporal", "arg1_id": "NCT02965443_inc_T14", "arg2_id": "NCT02965443_inc_T13", "normalized": [] }, { "id": "NCT02965443_inc_R9", "type": "Has_value", "arg1_id": "NCT02965443_inc_T12", "arg2_id": "NCT02965443_inc_T17", "normalized": [] } ]

[ { "id": "NCT02966236_exc_text", "type": "exclusion", "text": [ "Coronary artery disease - stent\nSevere chronic renal failure\nCongenital or acquired thrombophilia/thrombosis event\nKnown or suspected allergy\n" ], "offsets": [ [ 0, 142 ] ] } ]

[ { "id": "NCT02966236_exc_T1", "type": "Condition", "text": [ "Coronary artery disease" ], "offsets": [ [ 0, 23 ] ], "normalized": [] }, { "id": "NCT02966236_exc_T2", "type": "Device", "text": [ "stent" ], "offsets": [ [ 26, 31 ] ], "normalized": [] }, { "id": "NCT02966236_exc_T3", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 32, 38 ] ], "normalized": [] }, { "id": "NCT02966236_exc_T4", "type": "Qualifier", "text": [ "chronic" ], "offsets": [ [ 39, 46 ] ], "normalized": [] }, { "id": "NCT02966236_exc_T5", "type": "Condition", "text": [ "renal failure" ], "offsets": [ [ 47, 60 ] ], "normalized": [] }, { "id": "NCT02966236_exc_T6", "type": "Qualifier", "text": [ "Congenital" ], "offsets": [ [ 61, 71 ] ], "normalized": [] }, { "id": "NCT02966236_exc_T7", "type": "Qualifier", "text": [ "acquired" ], "offsets": [ [ 75, 83 ] ], "normalized": [] }, { "id": "NCT02966236_exc_T8", "type": "Condition", "text": [ "thrombophilia" ], "offsets": [ [ 84, 97 ] ], "normalized": [] }, { "id": "NCT02966236_exc_T9", "type": "Condition", "text": [ "thrombosis event" ], "offsets": [ [ 98, 114 ] ], "normalized": [] }, { "id": "NCT02966236_exc_T10", "type": "Scope", "text": [ "thrombophilia/thrombosis event" ], "offsets": [ [ 84, 114 ] ], "normalized": [] }, { "id": "NCT02966236_exc_T11", "type": "Scope", "text": [ "Congenital or acquired" ], "offsets": [ [ 61, 83 ] ], "normalized": [] }, { "id": "NCT02966236_exc_T12", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 134, 141 ] ], "normalized": [] }, { "id": "NCT02966236_exc_T13", "type": "Mood", "text": [ "Known" ], "offsets": [ [ 115, 120 ] ], "normalized": [] }, { "id": "NCT02966236_exc_T14", "type": "Mood", "text": [ "suspected" ], "offsets": [ [ 124, 133 ] ], "normalized": [] }, { "id": "NCT02966236_exc_T15", "type": "Scope", "text": [ "Known or suspected" ], "offsets": [ [ 115, 133 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02966236_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02966236_exc_T5", "arg2_id": "NCT02966236_exc_T4", "normalized": [] }, { "id": "NCT02966236_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02966236_exc_T5", "arg2_id": "NCT02966236_exc_T3", "normalized": [] }, { "id": "NCT02966236_exc_R3", "type": "Has_scope", "arg1_id": "NCT02966236_exc_T10", "arg2_id": "NCT02966236_exc_T11", "normalized": [] }, { "id": "NCT02966236_exc_R4", "type": "Has_scope", "arg1_id": "NCT02966236_exc_T12", "arg2_id": "NCT02966236_exc_T15", "normalized": [] } ]

[ { "id": "NCT02966236_inc_text", "type": "inclusion", "text": [ "Complex kidney stone (staghorn calculi GUYS III and IV)\n" ], "offsets": [ [ 0, 56 ] ] } ]

[ { "id": "NCT02966236_inc_T1", "type": "Condition", "text": [ "Complex kidney stone" ], "offsets": [ [ 0, 20 ] ], "normalized": [] }, { "id": "NCT02966236_inc_T2", "type": "Condition", "text": [ "staghorn calculi" ], "offsets": [ [ 22, 38 ] ], "normalized": [] }, { "id": "NCT02966236_inc_T3", "type": "Measurement", "text": [ "GUYS" ], "offsets": [ [ 39, 43 ] ], "normalized": [] }, { "id": "NCT02966236_inc_T4", "type": "Value", "text": [ "III and IV" ], "offsets": [ [ 44, 54 ] ], "normalized": [] }, { "id": "NCT02966236_inc_T5", "type": "Scope", "text": [ "staghorn calculi GUYS III and IV" ], "offsets": [ [ 22, 54 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02966236_inc_R1", "type": "Has_value", "arg1_id": "NCT02966236_inc_T3", "arg2_id": "NCT02966236_inc_T4", "normalized": [] }, { "id": "NCT02966236_inc_R2", "type": "AND", "arg1_id": "NCT02966236_inc_T2", "arg2_id": "NCT02966236_inc_T3", "normalized": [] }, { "id": "NCT02966236_inc_R3", "type": "Has_scope", "arg1_id": "NCT02966236_inc_T1", "arg2_id": "NCT02966236_inc_T5", "normalized": [] } ]

[ { "id": "NCT02968342_exc_text", "type": "exclusion", "text": [ "Medical history of chronic psychiatric disease\nMedical conditions associated with female sexual dysfunction; cardiovascular disease, uncontrolled chronic HT (hypertension) ,DM (diabetes mellitus), History of gynecologic surgery, female gynecological cancer ( breast, ovarian, uterine, cervical)\nMedications associated with female sexual dysfunction; Antidepressants opiates, beta blockers, Antiepileptics ( gabapentin, topiramate,phenytoin) benzodiazepines\n" ], "offsets": [ [ 0, 457 ] ] } ]

[ { "id": "NCT02968342_exc_T1", "type": "Observation", "text": [ "history" ], "offsets": [ [ 8, 15 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T2", "type": "Condition", "text": [ "chronic psychiatric disease" ], "offsets": [ [ 19, 46 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T3", "type": "Condition", "text": [ "female sexual dysfunction" ], "offsets": [ [ 82, 107 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T4", "type": "Condition", "text": [ "Medical conditions" ], "offsets": [ [ 47, 65 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T5", "type": "Qualifier", "text": [ "associated with female sexual dysfunction" ], "offsets": [ [ 66, 107 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T6", "type": "Condition", "text": [ "cardiovascular disease" ], "offsets": [ [ 109, 131 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T7", "type": "Qualifier", "text": [ "uncontrolled" ], "offsets": [ [ 133, 145 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T8", "type": "Qualifier", "text": [ "chronic" ], "offsets": [ [ 146, 153 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T9", "type": "Condition", "text": [ "HT" ], "offsets": [ [ 154, 156 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T10", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 158, 170 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T11", "type": "Condition", "text": [ "DM" ], "offsets": [ [ 173, 175 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T12", "type": "Condition", "text": [ "diabetes mellitus" ], "offsets": [ [ 177, 194 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T13", "type": "Procedure", "text": [ "gynecologic surgery" ], "offsets": [ [ 208, 227 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T14", "type": "Condition", "text": [ "female gynecological cancer" ], "offsets": [ [ 229, 256 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T15", "type": "Condition", "text": [ "breast" ], "offsets": [ [ 259, 265 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T16", "type": "Condition", "text": [ "ovarian" ], "offsets": [ [ 267, 274 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T17", "type": "Condition", "text": [ "uterine" ], "offsets": [ [ 276, 283 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T18", "type": "Condition", "text": [ "cervical" ], "offsets": [ [ 285, 293 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T19", "type": "Scope", "text": [ "breast, ovarian, uterine, cervical" ], "offsets": [ [ 259, 293 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T20", "type": "Observation", "text": [ "History" ], "offsets": [ [ 197, 204 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T21", "type": "Condition", "text": [ "female sexual dysfunction" ], "offsets": [ [ 323, 348 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T22", "type": "Drug", "text": [ "Medications" ], "offsets": [ [ 295, 306 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T23", "type": "Qualifier", "text": [ "associated with female sexual dysfunction" ], "offsets": [ [ 307, 348 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T24", "type": "Scope", "text": [ "cardiovascular disease, uncontrolled chronic HT (hypertension) ,DM (diabetes mellitus), History of gynecologic surgery, female gynecological cancer ( breast, ovarian, uterine, cervical)" ], "offsets": [ [ 109, 294 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T25", "type": "Scope", "text": [ "Medical conditions associated with female sexual dysfunction" ], "offsets": [ [ 47, 107 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T26", "type": "Drug", "text": [ "Antidepressants" ], "offsets": [ [ 350, 365 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T27", "type": "Drug", "text": [ "opiates" ], "offsets": [ [ 366, 373 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T28", "type": "Drug", "text": [ "beta blockers" ], "offsets": [ [ 375, 388 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T29", "type": "Drug", "text": [ "Antiepileptics" ], "offsets": [ [ 390, 404 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T30", "type": "Drug", "text": [ "gabapentin" ], "offsets": [ [ 407, 417 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T31", "type": "Drug", "text": [ "topiramate" ], "offsets": [ [ 419, 429 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T32", "type": "Drug", "text": [ "phenytoin" ], "offsets": [ [ 430, 439 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T33", "type": "Drug", "text": [ "benzodiazepines" ], "offsets": [ [ 441, 456 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T34", "type": "Scope", "text": [ "gabapentin, topiramate,phenytoin" ], "offsets": [ [ 407, 439 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T35", "type": "Scope", "text": [ "Antidepressants opiates, beta blockers, Antiepileptics ( gabapentin, topiramate,phenytoin) benzodiazepines" ], "offsets": [ [ 350, 456 ] ], "normalized": [] }, { "id": "NCT02968342_exc_T36", "type": "Scope", "text": [ "Medications associated with female sexual dysfunction" ], "offsets": [ [ 295, 348 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02968342_exc_R1", "type": "Has_temporal", "arg1_id": "NCT02968342_exc_T2", "arg2_id": "NCT02968342_exc_T1", "normalized": [] }, { "id": "NCT02968342_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02968342_exc_T4", "arg2_id": "NCT02968342_exc_T5", "normalized": [] }, { "id": "NCT02968342_exc_R4", "type": "Subsumes", "arg1_id": "NCT02968342_exc_T9", "arg2_id": "NCT02968342_exc_T10", "normalized": [] }, { "id": "NCT02968342_exc_R5", "type": "Subsumes", "arg1_id": "NCT02968342_exc_T11", "arg2_id": "NCT02968342_exc_T12", "normalized": [] }, { "id": "NCT02968342_exc_R6", "type": "Subsumes", "arg1_id": "NCT02968342_exc_T14", "arg2_id": "NCT02968342_exc_T19", "normalized": [] }, { "id": "NCT02968342_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT02968342_exc_T9", "arg2_id": "NCT02968342_exc_T8", "normalized": [] }, { "id": "NCT02968342_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT02968342_exc_T9", "arg2_id": "NCT02968342_exc_T7", "normalized": [] }, { "id": "NCT02968342_exc_R9", "type": "Has_temporal", "arg1_id": "NCT02968342_exc_T13", "arg2_id": "NCT02968342_exc_T20", "normalized": [] }, { "id": "NCT02968342_exc_R10", "type": "Subsumes", "arg1_id": "NCT02968342_exc_T25", "arg2_id": "NCT02968342_exc_T24", "normalized": [] }, { "id": "NCT02968342_exc_R11", "type": "Has_qualifier", "arg1_id": "NCT02968342_exc_T22", "arg2_id": "NCT02968342_exc_T23", "normalized": [] }, { "id": "NCT02968342_exc_R12", "type": "Subsumes", "arg1_id": "NCT02968342_exc_T29", "arg2_id": "NCT02968342_exc_T34", "normalized": [] }, { "id": "NCT02968342_exc_R13", "type": "Subsumes", "arg1_id": "NCT02968342_exc_T36", "arg2_id": "NCT02968342_exc_T35", "normalized": [] } ]

[ { "id": "NCT02968342_inc_text", "type": "inclusion", "text": [ "Menopausal status\nSexually active\n" ], "offsets": [ [ 0, 34 ] ] } ]

[ { "id": "NCT02968342_inc_T1", "type": "Condition", "text": [ "Menopausal" ], "offsets": [ [ 0, 10 ] ], "normalized": [] }, { "id": "NCT02968342_inc_T2", "type": "Observation", "text": [ "Sexually active" ], "offsets": [ [ 18, 33 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "NCT02968602_exc_text", "type": "exclusion", "text": [ "History of organic brain disease\nDSM-IV diagnosis of Alcohol or Substance Dependence within the last six months (except nicotine) or DSM-5 diagnosis of Substance Use Disorder in the last six months (except nicotine)\nDSM-IV diagnosis of Alcohol or Substance Abuse within the last one month (except nicotine) or DSM-5 diagnosis of Substance Use Disorder in the last six months (except nicotine)\nPregnancy or lactation\nSevere liver dysfunction (LFT 3X upper limit of normal)\nPrevious known hypersensitivity to tetracyclines\nCurrent treatment with tetracycline or derivative\nTreatment with oral contraceptives (unless a second form of birth control is used and documented)\nTreatment with cholestyramine or colestipol\nTreatment with Urinary alkalinizers (e.g., sodium lactate, potassium citrate)\nTreatment with warfarin\nTreatment with bupropion, varenicline, or nicotine replacement products in the month prior to study inclusion\nLess than two months treatment of adjunctive medications AND less than one month on same dose: beta blockers, antidepressants, mood stabilizers, antianxiety medications.\nMedical condition whose pathology or treatment would significantly increase the risk associated with the proposed protocol.\nHistory of head injury, seizures, or stroke\nPositive urine toxicology screen for substances of non-therapeutic use prior to craving assessments\n" ], "offsets": [ [ 0, 1363 ] ] } ]

[ { "id": "NCT02968602_exc_T1", "type": "Condition", "text": [ "organic brain disease" ], "offsets": [ [ 11, 32 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T2", "type": "Observation", "text": [ "History of" ], "offsets": [ [ 0, 10 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T3", "type": "Qualifier", "text": [ "DSM-IV" ], "offsets": [ [ 33, 39 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T4", "type": "Condition", "text": [ "lcohol", "ependence" ], "offsets": [ [ 54, 60 ], [ 75, 84 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T5", "type": "Condition", "text": [ "Substance Dependence" ], "offsets": [ [ 64, 84 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T6", "type": "Scope", "text": [ "Alcohol or Substance Dependence" ], "offsets": [ [ 53, 84 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T7", "type": "Temporal", "text": [ "within the last six months" ], "offsets": [ [ 85, 111 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T8", "type": "Drug", "text": [ "nicotine" ], "offsets": [ [ 120, 128 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T9", "type": "Negation", "text": [ "except" ], "offsets": [ [ 113, 119 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T10", "type": "Qualifier", "text": [ "DSM-5" ], "offsets": [ [ 133, 138 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T11", "type": "Condition", "text": [ "Substance Use Disorder" ], "offsets": [ [ 152, 174 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T12", "type": "Temporal", "text": [ "in the last six months" ], "offsets": [ [ 175, 197 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T13", "type": "Drug", "text": [ "nicotine" ], "offsets": [ [ 206, 214 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T14", "type": "Negation", "text": [ "except" ], "offsets": [ [ 199, 205 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T15", "type": "Qualifier", "text": [ "DSM-IV" ], "offsets": [ [ 216, 222 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T16", "type": "Condition", "text": [ "cohol o", "use w" ], "offsets": [ [ 238, 245 ], [ 259, 264 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T17", "type": "Condition", "text": [ "Substance Abuse" ], "offsets": [ [ 247, 262 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T18", "type": "Scope", "text": [ "Alcohol or Substance Abuse" ], "offsets": [ [ 236, 262 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T19", "type": "Temporal", "text": [ "within the last one month" ], "offsets": [ [ 263, 288 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T20", "type": "Drug", "text": [ "nicotine" ], "offsets": [ [ 297, 305 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T21", "type": "Negation", "text": [ "except" ], "offsets": [ [ 290, 296 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T22", "type": "Qualifier", "text": [ "DSM-5" ], "offsets": [ [ 310, 315 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T23", "type": "Condition", "text": [ "Substance Use Disorder" ], "offsets": [ [ 329, 351 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T24", "type": "Temporal", "text": [ "in the last six months" ], "offsets": [ [ 352, 374 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T25", "type": "Drug", "text": [ "nicotine" ], "offsets": [ [ 383, 391 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T26", "type": "Negation", "text": [ "except" ], "offsets": [ [ 376, 382 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T27", "type": "Scope", "text": [ "DSM-5 diagnosis of Substance Use Disorder in the last six months (except nicotine)" ], "offsets": [ [ 310, 392 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T28", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 393, 402 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T29", "type": "Condition", "text": [ "lactation" ], "offsets": [ [ 406, 415 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T30", "type": "Condition", "text": [ "liver dysfunction" ], "offsets": [ [ 423, 440 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T31", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 416, 422 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T32", "type": "Measurement", "text": [ "LFT" ], "offsets": [ [ 442, 445 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T33", "type": "Value", "text": [ "3X upper limit of normal" ], "offsets": [ [ 446, 470 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T34", "type": "Scope", "text": [ "LFT 3X upper limit of normal" ], "offsets": [ [ 442, 470 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T35", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 487, 503 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T36", "type": "Drug", "text": [ "tetracyclines" ], "offsets": [ [ 507, 520 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T37", "type": "Temporal", "text": [ "Previous" ], "offsets": [ [ 472, 480 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T38", "type": "Temporal", "text": [ "Current" ], "offsets": [ [ 521, 528 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T39", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 529, 538 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T40", "type": "Drug", "text": [ "tetracycline" ], "offsets": [ [ 544, 556 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T41", "type": "Drug", "text": [ "ycline or de", "tive\nTreat" ], "offsets": [ [ 550, 562 ], [ 566, 576 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T42", "type": "Scope", "text": [ "tetracycline or derivative" ], "offsets": [ [ 544, 570 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T43", "type": "Drug", "text": [ "oral contraceptives" ], "offsets": [ [ 586, 605 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T44", "type": "Procedure", "text": [ "Treatment" ], "offsets": [ [ 571, 580 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T45", "type": "Observation", "text": [ "birth control" ], "offsets": [ [ 631, 644 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T46", "type": "Qualifier", "text": [ "second form" ], "offsets": [ [ 616, 627 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T47", "type": "Negation", "text": [ "unless" ], "offsets": [ [ 607, 613 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T48", "type": "Drug", "text": [ "cholestyramine" ], "offsets": [ [ 684, 698 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T49", "type": "Drug", "text": [ "colestipol" ], "offsets": [ [ 702, 712 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T50", "type": "Procedure", "text": [ "Treatment" ], "offsets": [ [ 669, 678 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T51", "type": "Scope", "text": [ "cholestyramine or colestipol" ], "offsets": [ [ 684, 712 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T52", "type": "Procedure", "text": [ "Treatment" ], "offsets": [ [ 713, 722 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T53", "type": "Drug", "text": [ "Urinary alkalinizers" ], "offsets": [ [ 728, 748 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T54", "type": "Drug", "text": [ "sodium lactate" ], "offsets": [ [ 756, 770 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T55", "type": "Drug", "text": [ "potassium citrate" ], "offsets": [ [ 772, 789 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T56", "type": "Scope", "text": [ "sodium lactate, potassium citrate" ], "offsets": [ [ 756, 789 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T57", "type": "Drug", "text": [ "warfarin" ], "offsets": [ [ 806, 814 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T58", "type": "Procedure", "text": [ "Treatment" ], "offsets": [ [ 791, 800 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T59", "type": "Drug", "text": [ "bupropion" ], "offsets": [ [ 830, 839 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T60", "type": "Drug", "text": [ "varenicline" ], "offsets": [ [ 841, 852 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T61", "type": "Drug", "text": [ "nicotine replacement products" ], "offsets": [ [ 857, 886 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T62", "type": "Scope", "text": [ "bupropion, varenicline, or nicotine replacement products" ], "offsets": [ [ 830, 886 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T63", "type": "Temporal", "text": [ "in the month prior to study inclusion" ], "offsets": [ [ 887, 924 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T64", "type": "Reference_point", "text": [ "study inclusion" ], "offsets": [ [ 909, 924 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T65", "type": "Procedure", "text": [ "Treatment" ], "offsets": [ [ 815, 824 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T66", "type": "Multiplier", "text": [ "Less than two months" ], "offsets": [ [ 925, 945 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T67", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 946, 955 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T68", "type": "Drug", "text": [ "adjunctive medications" ], "offsets": [ [ 959, 981 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T69", "type": "Multiplier", "text": [ "less than one month" ], "offsets": [ [ 986, 1005 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T70", "type": "Multiplier", "text": [ "same dose" ], "offsets": [ [ 1009, 1018 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T71", "type": "Drug", "text": [ "beta blockers" ], "offsets": [ [ 1020, 1033 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T72", "type": "Drug", "text": [ "antidepressants" ], "offsets": [ [ 1035, 1050 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T73", "type": "Drug", "text": [ "mood stabilizers" ], "offsets": [ [ 1052, 1068 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T74", "type": "Drug", "text": [ "antianxiety medications" ], "offsets": [ [ 1070, 1093 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T75", "type": "Scope", "text": [ "beta blockers, antidepressants, mood stabilizers, antianxiety medications" ], "offsets": [ [ 1020, 1093 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T76", "type": "Condition", "text": [ "Medical condition" ], "offsets": [ [ 1095, 1112 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T77", "type": "Qualifier", "text": [ "would significantly increase the risk associated with the proposed protocol" ], "offsets": [ [ 1142, 1217 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T78", "type": "Condition", "text": [ "head injury" ], "offsets": [ [ 1230, 1241 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T79", "type": "Condition", "text": [ "seizures" ], "offsets": [ [ 1243, 1251 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T80", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 1256, 1262 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T81", "type": "Observation", "text": [ "History" ], "offsets": [ [ 1219, 1226 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T82", "type": "Scope", "text": [ "head injury, seizures, or stroke" ], "offsets": [ [ 1230, 1262 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T83", "type": "Measurement", "text": [ "urine toxicology screen" ], "offsets": [ [ 1272, 1295 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T84", "type": "Qualifier", "text": [ "substances of non-therapeutic use" ], "offsets": [ [ 1300, 1333 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T85", "type": "Value", "text": [ "Positive" ], "offsets": [ [ 1263, 1271 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T86", "type": "Temporal", "text": [ "prior to craving assessments" ], "offsets": [ [ 1334, 1362 ] ], "normalized": [] }, { "id": "NCT02968602_exc_T87", "type": "Reference_point", "text": [ "craving assessments" ], "offsets": [ [ 1343, 1362 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02968602_exc_R1", "type": "Has_temporal", "arg1_id": "NCT02968602_exc_T1", "arg2_id": "NCT02968602_exc_T2", "normalized": [] }, { "id": "NCT02968602_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02968602_exc_T6", "arg2_id": "NCT02968602_exc_T3", "normalized": [] }, { "id": "NCT02968602_exc_R3", "type": "Has_temporal", "arg1_id": "NCT02968602_exc_T6", "arg2_id": "NCT02968602_exc_T7", "normalized": [] }, { "id": "NCT02968602_exc_R4", "type": "Has_negation", "arg1_id": "NCT02968602_exc_T8", "arg2_id": "NCT02968602_exc_T9", "normalized": [] }, { "id": "NCT02968602_exc_R5", "type": "AND", "arg1_id": "NCT02968602_exc_T6", "arg2_id": "NCT02968602_exc_T8", "normalized": [] }, { "id": "NCT02968602_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02968602_exc_T11", "arg2_id": "NCT02968602_exc_T10", "normalized": [] }, { "id": "NCT02968602_exc_R7", "type": "Has_negation", "arg1_id": "NCT02968602_exc_T13", "arg2_id": "NCT02968602_exc_T14", "normalized": [] }, { "id": "NCT02968602_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02968602_exc_T11", "arg2_id": "NCT02968602_exc_T12", "normalized": [] }, { "id": "NCT02968602_exc_R9", "type": "Has_negation", "arg1_id": "NCT02968602_exc_T11", "arg2_id": "NCT02968602_exc_T14", "normalized": [] }, { "id": "NCT02968602_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT02968602_exc_T18", "arg2_id": "NCT02968602_exc_T15", "normalized": [] }, { "id": "NCT02968602_exc_R11", "type": "Has_negation", "arg1_id": "NCT02968602_exc_T20", "arg2_id": "NCT02968602_exc_T21", "normalized": [] }, { "id": "NCT02968602_exc_R12", "type": "Has_temporal", "arg1_id": "NCT02968602_exc_T18", "arg2_id": "NCT02968602_exc_T19", "normalized": [] }, { "id": "NCT02968602_exc_R13", "type": "AND", "arg1_id": "NCT02968602_exc_T18", "arg2_id": "NCT02968602_exc_T20", "normalized": [] }, { "id": "NCT02968602_exc_R14", "type": "Has_temporal", "arg1_id": "NCT02968602_exc_T23", "arg2_id": "NCT02968602_exc_T24", "normalized": [] }, { "id": "NCT02968602_exc_R15", "type": "Has_qualifier", "arg1_id": "NCT02968602_exc_T23", "arg2_id": "NCT02968602_exc_T22", "normalized": [] }, { "id": "NCT02968602_exc_R16", "type": "Has_negation", "arg1_id": "NCT02968602_exc_T25", "arg2_id": "NCT02968602_exc_T26", "normalized": [] }, { "id": "NCT02968602_exc_R17", "type": "AND", "arg1_id": "NCT02968602_exc_T23", "arg2_id": "NCT02968602_exc_T25", "normalized": [] }, { "id": "NCT02968602_exc_R18", "type": "Has_qualifier", "arg1_id": "NCT02968602_exc_T30", "arg2_id": "NCT02968602_exc_T31", "normalized": [] }, { "id": "NCT02968602_exc_R19", "type": "Has_value", "arg1_id": "NCT02968602_exc_T32", "arg2_id": "NCT02968602_exc_T33", "normalized": [] }, { "id": "NCT02968602_exc_R20", "type": "Has_scope", "arg1_id": "NCT02968602_exc_T30", "arg2_id": "NCT02968602_exc_T34", "normalized": [] }, { "id": "NCT02968602_exc_R21", "type": "AND", "arg1_id": "NCT02968602_exc_T35", "arg2_id": "NCT02968602_exc_T36", "normalized": [] }, { "id": "NCT02968602_exc_R22", "type": "Has_temporal", "arg1_id": "NCT02968602_exc_T35", "arg2_id": "NCT02968602_exc_T37", "normalized": [] }, { "id": "NCT02968602_exc_R23", "type": "Has_temporal", "arg1_id": "NCT02968602_exc_T39", "arg2_id": "NCT02968602_exc_T38", "normalized": [] }, { "id": "NCT02968602_exc_R24", "type": "Has_scope", "arg1_id": "NCT02968602_exc_T39", "arg2_id": "NCT02968602_exc_T42", "normalized": [] }, { "id": "NCT02968602_exc_R25", "type": "AND", "arg1_id": "NCT02968602_exc_T44", "arg2_id": "NCT02968602_exc_T43", "normalized": [] }, { "id": "NCT02968602_exc_R26", "type": "Has_qualifier", "arg1_id": "NCT02968602_exc_T45", "arg2_id": "NCT02968602_exc_T46", "normalized": [] }, { "id": "NCT02968602_exc_R27", "type": "Has_negation", "arg1_id": "NCT02968602_exc_T45", "arg2_id": "NCT02968602_exc_T47", "normalized": [] }, { "id": "NCT02968602_exc_R29", "type": "Has_scope", "arg1_id": "NCT02968602_exc_T50", "arg2_id": "NCT02968602_exc_T51", "normalized": [] }, { "id": "NCT02968602_exc_R30", "type": "Subsumes", "arg1_id": "NCT02968602_exc_T53", "arg2_id": "NCT02968602_exc_T56", "normalized": [] }, { "id": "NCT02968602_exc_R31", "type": "AND", "arg1_id": "NCT02968602_exc_T52", "arg2_id": "NCT02968602_exc_T53", "normalized": [] }, { "id": "NCT02968602_exc_R32", "type": "AND", "arg1_id": "NCT02968602_exc_T58", "arg2_id": "NCT02968602_exc_T57", "normalized": [] }, { "id": "NCT02968602_exc_R33", "type": "Has_index", "arg1_id": "NCT02968602_exc_T63", "arg2_id": "NCT02968602_exc_T64", "normalized": [] }, { "id": "NCT02968602_exc_R34", "type": "Has_scope", "arg1_id": "NCT02968602_exc_T65", "arg2_id": "NCT02968602_exc_T62", "normalized": [] }, { "id": "NCT02968602_exc_R35", "type": "Has_temporal", "arg1_id": "NCT02968602_exc_T62", "arg2_id": "NCT02968602_exc_T63", "normalized": [] }, { "id": "NCT02968602_exc_R36", "type": "AND", "arg1_id": "NCT02968602_exc_T67", "arg2_id": "NCT02968602_exc_T68", "normalized": [] }, { "id": "NCT02968602_exc_R37", "type": "Has_multiplier", "arg1_id": "NCT02968602_exc_T67", "arg2_id": "NCT02968602_exc_T66", "normalized": [] }, { "id": "NCT02968602_exc_R38", "type": "Has_multiplier", "arg1_id": "NCT02968602_exc_T70", "arg2_id": "NCT02968602_exc_T69", "normalized": [] }, { "id": "NCT02968602_exc_R39", "type": "Has_multiplier", "arg1_id": "NCT02968602_exc_T67", "arg2_id": "NCT02968602_exc_T70", "normalized": [] }, { "id": "NCT02968602_exc_R40", "type": "Subsumes", "arg1_id": "NCT02968602_exc_T68", "arg2_id": "NCT02968602_exc_T75", "normalized": [] }, { "id": "NCT02968602_exc_R41", "type": "Has_qualifier", "arg1_id": "NCT02968602_exc_T76", "arg2_id": "NCT02968602_exc_T77", "normalized": [] }, { "id": "NCT02968602_exc_R42", "type": "Has_temporal", "arg1_id": "NCT02968602_exc_T82", "arg2_id": "NCT02968602_exc_T81", "normalized": [] }, { "id": "NCT02968602_exc_R43", "type": "Has_qualifier", "arg1_id": "NCT02968602_exc_T83", "arg2_id": "NCT02968602_exc_T84", "normalized": [] }, { "id": "NCT02968602_exc_R44", "type": "Has_value", "arg1_id": "NCT02968602_exc_T83", "arg2_id": "NCT02968602_exc_T85", "normalized": [] }, { "id": "NCT02968602_exc_R45", "type": "Has_index", "arg1_id": "NCT02968602_exc_T86", "arg2_id": "NCT02968602_exc_T87", "normalized": [] }, { "id": "NCT02968602_exc_R46", "type": "Has_temporal", "arg1_id": "NCT02968602_exc_T83", "arg2_id": "NCT02968602_exc_T86", "normalized": [] } ]

[ { "id": "NCT02968602_inc_text", "type": "inclusion", "text": [ "DSM-IV or DSM-5 diagnosis of schizophrenia or schizoaffective disorder\nMale or Female\nAge: 18 to 65 years\nCaucasian or Non-Caucasian\nSmoke at least 10 cigarettes daily\nUrine cotinine level ? 100 ng/ml (NicAlert(r) reading ? 3)\nAgrees to wear a head mounted display (HMD) for up to 45 minutes\nAble to complete the Evaluation to Sign Consent (ESC) with minimum score of 80%\n" ], "offsets": [ [ 0, 372 ] ] } ]

[ { "id": "NCT02968602_inc_T1", "type": "Qualifier", "text": [ "DSM-IV" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T2", "type": "Qualifier", "text": [ "DSM-5" ], "offsets": [ [ 10, 15 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T3", "type": "Condition", "text": [ "schizophrenia" ], "offsets": [ [ 29, 42 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T4", "type": "Condition", "text": [ "schizoaffective disorder" ], "offsets": [ [ 46, 70 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T5", "type": "Scope", "text": [ "schizophrenia or schizoaffective disorder" ], "offsets": [ [ 29, 70 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T6", "type": "Scope", "text": [ "DSM-IV or DSM-5" ], "offsets": [ [ 0, 15 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T7", "type": "Person", "text": [ "Male" ], "offsets": [ [ 71, 75 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T8", "type": "Person", "text": [ "Female" ], "offsets": [ [ 79, 85 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T9", "type": "Person", "text": [ "Age" ], "offsets": [ [ 86, 89 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T10", "type": "Value", "text": [ "18 to 65 years" ], "offsets": [ [ 91, 105 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T11", "type": "Person", "text": [ "Caucasian" ], "offsets": [ [ 106, 115 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T12", "type": "Person", "text": [ "Non-Caucasian" ], "offsets": [ [ 119, 132 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T13", "type": "Observation", "text": [ "Smoke" ], "offsets": [ [ 133, 138 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T14", "type": "Value", "text": [ "at least 10 cigarettes daily" ], "offsets": [ [ 139, 167 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T15", "type": "Measurement", "text": [ "Urine cotinine level" ], "offsets": [ [ 168, 188 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T16", "type": "Value", "text": [ "? 100 ng/ml" ], "offsets": [ [ 189, 200 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T17", "type": "Measurement", "text": [ "NicAlert(r)" ], "offsets": [ [ 202, 213 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T18", "type": "Value", "text": [ "? 3" ], "offsets": [ [ 222, 225 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T19", "type": "Scope", "text": [ "NicAlert(r) reading ? 3" ], "offsets": [ [ 202, 225 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T20", "type": "Scope", "text": [ "Urine cotinine level ? 100 ng/ml" ], "offsets": [ [ 168, 200 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T21", "type": "Observation", "text": [ "Agrees to wear" ], "offsets": [ [ 227, 241 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T22", "type": "Device", "text": [ "head mounted display (HMD)" ], "offsets": [ [ 244, 270 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T23", "type": "Temporal", "text": [ "for up to 45 minutes" ], "offsets": [ [ 271, 291 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T24", "type": "Observation", "text": [ "Able to complete" ], "offsets": [ [ 292, 308 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T25", "type": "Procedure", "text": [ "Evaluation to Sign Consent (ESC)" ], "offsets": [ [ 313, 345 ] ], "normalized": [] }, { "id": "NCT02968602_inc_T26", "type": "Value", "text": [ "minimum score of 80%" ], "offsets": [ [ 351, 371 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02968602_inc_R1", "type": "Has_scope", "arg1_id": "NCT02968602_inc_T5", "arg2_id": "NCT02968602_inc_T6", "normalized": [] }, { "id": "NCT02968602_inc_R2", "type": "Has_value", "arg1_id": "NCT02968602_inc_T9", "arg2_id": "NCT02968602_inc_T10", "normalized": [] }, { "id": "NCT02968602_inc_R3", "type": "Has_value", "arg1_id": "NCT02968602_inc_T13", "arg2_id": "NCT02968602_inc_T14", "normalized": [] }, { "id": "NCT02968602_inc_R4", "type": "Has_value", "arg1_id": "NCT02968602_inc_T15", "arg2_id": "NCT02968602_inc_T16", "normalized": [] }, { "id": "NCT02968602_inc_R5", "type": "Has_value", "arg1_id": "NCT02968602_inc_T17", "arg2_id": "NCT02968602_inc_T18", "normalized": [] }, { "id": "NCT02968602_inc_R6", "type": "Subsumes", "arg1_id": "NCT02968602_inc_T20", "arg2_id": "NCT02968602_inc_T19", "normalized": [] }, { "id": "NCT02968602_inc_R7", "type": "AND", "arg1_id": "NCT02968602_inc_T21", "arg2_id": "NCT02968602_inc_T22", "normalized": [] }, { "id": "NCT02968602_inc_R8", "type": "Has_temporal", "arg1_id": "NCT02968602_inc_T21", "arg2_id": "NCT02968602_inc_T23", "normalized": [] }, { "id": "NCT02968602_inc_R9", "type": "Has_value", "arg1_id": "NCT02968602_inc_T25", "arg2_id": "NCT02968602_inc_T26", "normalized": [] } ]

[ { "id": "NCT02969187_exc_text", "type": "exclusion", "text": [ "BMI <35 and > 60 kg/m2\nInability to walk (bed-bound or wheelchair dependence)\nopen abdominal surgeries except simple appendectomy and common OB/GYN procedures in the pelvis (hysterectomy, C-section, and oophorectomy, tubal ligation)\nlaparoscopic bowel or solid organ resection except laparoscopic cholecystectomy\nventral hernia repair with mesh\nPreoperative chronic opiate use for chronic pain defined as opiate usage at least 60 mg/day of morphine equivalent for = 3 months (as defined by International Association for the Study of Pain22) in the one year period prior to the bariatric surgery\nThe American Society of Anesthesiologists (ASA) score > 3\nHistory of hypersensitivity or adverse reaction to bupivacaine or narcotics\nInability to speak English\nventral hernia repair\nCholecystectomy\nhiatal hernia repair with posterior cruroplasty\nextensive lysis of adhesions\nother procedures that mandate addition of \"trocar(s)\" or \"feeding tube\"\nAddition of trocar(s) or conversion of surgery to hand-assisted or open\n" ], "offsets": [ [ 0, 1015 ] ] } ]

[ { "id": "NCT02969187_exc_T1", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T2", "type": "Value", "text": [ "<35 and > 60 kg/m2" ], "offsets": [ [ 4, 22 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T3", "type": "Condition", "text": [ "Inability to walk" ], "offsets": [ [ 23, 40 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T4", "type": "Condition", "text": [ "wheelchair dependence" ], "offsets": [ [ 55, 76 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T5", "type": "Condition", "text": [ "bed-bound" ], "offsets": [ [ 42, 51 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T6", "type": "Scope", "text": [ "bed-bound or wheelchair dependence" ], "offsets": [ [ 42, 76 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T7", "type": "Procedure", "text": [ "open abdominal surgeries" ], "offsets": [ [ 78, 102 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T8", "type": "Procedure", "text": [ "simple appendectomy" ], "offsets": [ [ 110, 129 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T9", "type": "Procedure", "text": [ "common OB/GYN procedures" ], "offsets": [ [ 134, 158 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T10", "type": "Qualifier", "text": [ "pelvis" ], "offsets": [ [ 166, 172 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T11", "type": "Procedure", "text": [ "hysterectomy" ], "offsets": [ [ 174, 186 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T12", "type": "Procedure", "text": [ "C-section" ], "offsets": [ [ 188, 197 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T13", "type": "Procedure", "text": [ "oophorectomy" ], "offsets": [ [ 203, 215 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T14", "type": "Procedure", "text": [ "tubal ligation" ], "offsets": [ [ 217, 231 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T15", "type": "Scope", "text": [ "hysterectomy, C-section, and oophorectomy, tubal ligation" ], "offsets": [ [ 174, 231 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T16", "type": "Scope", "text": [ "common OB/GYN procedures in the pelvis" ], "offsets": [ [ 134, 172 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T17", "type": "Negation", "text": [ "except" ], "offsets": [ [ 103, 109 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T18", "type": "Scope", "text": [ "simple appendectomy and common OB/GYN procedures in the pelvis (hysterectomy, C-section, and oophorectomy, tubal ligation)" ], "offsets": [ [ 110, 232 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T19", "type": "Procedure", "text": [ "aroscopic bowel or", "ection ex" ], "offsets": [ [ 236, 254 ], [ 270, 279 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T20", "type": "Procedure", "text": [ "solid organ resection" ], "offsets": [ [ 255, 276 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T21", "type": "Procedure", "text": [ "laparoscopic cholecystectomy" ], "offsets": [ [ 284, 312 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T22", "type": "Negation", "text": [ "except" ], "offsets": [ [ 277, 283 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T23", "type": "Scope", "text": [ "laparoscopic bowel or solid organ resection" ], "offsets": [ [ 233, 276 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T24", "type": "Condition", "text": [ "ventral hernia" ], "offsets": [ [ 313, 327 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T25", "type": "Procedure", "text": [ "repair with mesh" ], "offsets": [ [ 328, 344 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T26", "type": "Temporal", "text": [ "Preoperative" ], "offsets": [ [ 345, 357 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T28", "type": "Condition", "text": [ "chronic pain" ], "offsets": [ [ 381, 393 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T29", "type": "Drug", "text": [ "opiate" ], "offsets": [ [ 366, 372 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T27", "type": "Multiplier", "text": [ "chronic" ], "offsets": [ [ 358, 365 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T30", "type": "Drug", "text": [ "opiate" ], "offsets": [ [ 405, 411 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T31", "type": "Multiplier", "text": [ "at least 60 mg/day of morphine equivalent" ], "offsets": [ [ 418, 459 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T32", "type": "Multiplier", "text": [ "for = 3 months" ], "offsets": [ [ 460, 474 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T33", "type": "Temporal", "text": [ "in the one year period prior to the bariatric surgery" ], "offsets": [ [ 541, 594 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T34", "type": "Reference_point", "text": [ "the bariatric surgery" ], "offsets": [ [ 573, 594 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T35", "type": "Procedure", "text": [ "bariatric surgery" ], "offsets": [ [ 577, 594 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T36", "type": "Scope", "text": [ "opiate usage at least 60 mg/day of morphine equivalent for = 3 months" ], "offsets": [ [ 405, 474 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T37", "type": "Scope", "text": [ "chronic opiate use for chronic pain" ], "offsets": [ [ 358, 393 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T38", "type": "Measurement", "text": [ "American Society of Anesthesiologists (ASA) score" ], "offsets": [ [ 599, 648 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T39", "type": "Value", "text": [ "> 3" ], "offsets": [ [ 649, 652 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T40", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 664, 680 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T41", "type": "Condition", "text": [ "adverse reaction" ], "offsets": [ [ 684, 700 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T42", "type": "Drug", "text": [ "bupivacaine" ], "offsets": [ [ 704, 715 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T43", "type": "Drug", "text": [ "narcotics" ], "offsets": [ [ 719, 728 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T44", "type": "Scope", "text": [ "hypersensitivity or adverse reaction" ], "offsets": [ [ 664, 700 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T45", "type": "Scope", "text": [ "bupivacaine or narcotics" ], "offsets": [ [ 704, 728 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T47", "type": "Condition", "text": [ "ventral hernia" ], "offsets": [ [ 756, 770 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T48", "type": "Procedure", "text": [ "repair" ], "offsets": [ [ 771, 777 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T49", "type": "Procedure", "text": [ "Cholecystectomy" ], "offsets": [ [ 778, 793 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T50", "type": "Condition", "text": [ "hiatal hernia" ], "offsets": [ [ 794, 807 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T51", "type": "Procedure", "text": [ "repair" ], "offsets": [ [ 808, 814 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T52", "type": "Procedure", "text": [ "posterior cruroplasty" ], "offsets": [ [ 820, 841 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T53", "type": "Condition", "text": [ "lysis of adhesions" ], "offsets": [ [ 852, 870 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T54", "type": "Qualifier", "text": [ "extensive" ], "offsets": [ [ 842, 851 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T56", "type": "Drug", "text": [ "trocar" ], "offsets": [ [ 955, 961 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T57", "type": "Observation", "text": [ "conversion of surgery" ], "offsets": [ [ 968, 989 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T58", "type": "Procedure", "text": [ "hand-assisted" ], "offsets": [ [ 993, 1006 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T59", "type": "Procedure", "text": [ "open" ], "offsets": [ [ 1010, 1014 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T60", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 982, 989 ] ], "normalized": [] }, { "id": "NCT02969187_exc_T61", "type": "Mood", "text": [ "Addition of" ], "offsets": [ [ 943, 954 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT02969187_exc_R1", "type": "Has_value", "arg1_id": "NCT02969187_exc_T1", "arg2_id": "NCT02969187_exc_T2", "normalized": [] }, { "id": "NCT02969187_exc_R2", "type": "Subsumes", "arg1_id": "NCT02969187_exc_T3", "arg2_id": "NCT02969187_exc_T6", "normalized": [] }, { "id": "NCT02969187_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02969187_exc_T9", "arg2_id": "NCT02969187_exc_T10", "normalized": [] }, { "id": "NCT02969187_exc_R4", "type": "Subsumes", "arg1_id": "NCT02969187_exc_T16", "arg2_id": "NCT02969187_exc_T15", "normalized": [] }, { "id": "NCT02969187_exc_R5", "type": "Has_negation", "arg1_id": "NCT02969187_exc_T18", "arg2_id": "NCT02969187_exc_T17", "normalized": [] }, { "id": "NCT02969187_exc_R6", "type": "Has_scope", "arg1_id": "NCT02969187_exc_T7", "arg2_id": "NCT02969187_exc_T18", "normalized": [] }, { "id": "NCT02969187_exc_R7", "type": "Has_negation", "arg1_id": "NCT02969187_exc_T21", "arg2_id": "NCT02969187_exc_T22", "normalized": [] }, { "id": "NCT02969187_exc_R8", "type": "AND", "arg1_id": "NCT02969187_exc_T23", "arg2_id": "NCT02969187_exc_T21", "normalized": [] }, { "id": "NCT02969187_exc_R9", "type": "AND", "arg1_id": "NCT02969187_exc_T25", "arg2_id": "NCT02969187_exc_T24", "normalized": [] }, { "id": "NCT02969187_exc_R10", "type": "Has_multiplier", "arg1_id": "NCT02969187_exc_T29", "arg2_id": "NCT02969187_exc_T27", "normalized": [] }, { "id": "NCT02969187_exc_R11", "type": "AND", "arg1_id": "NCT02969187_exc_T29", "arg2_id": "NCT02969187_exc_T28", "normalized": [] }, { "id": "NCT02969187_exc_R12", "type": "Has_temporal", "arg1_id": "NCT02969187_exc_T29", "arg2_id": "NCT02969187_exc_T26", "normalized": [] }, { "id": "NCT02969187_exc_R13", "type": "Has_multiplier", "arg1_id": "NCT02969187_exc_T30", "arg2_id": "NCT02969187_exc_T31", "normalized": [] }, { "id": "NCT02969187_exc_R14", "type": "Has_multiplier", "arg1_id": "NCT02969187_exc_T30", "arg2_id": "NCT02969187_exc_T32", "normalized": [] }, { "id": "NCT02969187_exc_R16", "type": "AND", "arg1_id": "NCT02969187_exc_T33", "arg2_id": "NCT02969187_exc_T35", "normalized": [] }, { "id": "NCT02969187_exc_R17", "type": "Has_temporal", "arg1_id": "NCT02969187_exc_T30", "arg2_id": "NCT02969187_exc_T33", "normalized": [] }, { "id": "NCT02969187_exc_R18", "type": "Subsumes", "arg1_id": "NCT02969187_exc_T37", "arg2_id": "NCT02969187_exc_T36", "normalized": [] }, { "id": "NCT02969187_exc_R19", "type": "Has_value", "arg1_id": "NCT02969187_exc_T38", "arg2_id": "NCT02969187_exc_T39", "normalized": [] }, { "id": "NCT02969187_exc_R20", "type": "Has_scope", "arg1_id": "NCT02969187_exc_T44", "arg2_id": "NCT02969187_exc_T45", "normalized": [] }, { "id": "NCT02969187_exc_R21", "type": "AND", "arg1_id": "NCT02969187_exc_T48", "arg2_id": "NCT02969187_exc_T47", "normalized": [] }, { "id": "NCT02969187_exc_R22", "type": "AND", "arg1_id": "NCT02969187_exc_T51", "arg2_id": "NCT02969187_exc_T50", "normalized": [] }, { "id": "NCT02969187_exc_R23", "type": "AND", "arg1_id": "NCT02969187_exc_T51", "arg2_id": "NCT02969187_exc_T52", "normalized": [] }, { "id": "NCT02969187_exc_R24", "type": "Has_qualifier", "arg1_id": "NCT02969187_exc_T53", "arg2_id": "NCT02969187_exc_T54", "normalized": [] }, { "id": "NCT02969187_exc_R26", "type": "Has_mood", "arg1_id": "NCT02969187_exc_T56", "arg2_id": "NCT02969187_exc_T61", "normalized": [] }, { "id": "NCT02969187_exc_R27", "type": "AND", "arg1_id": "NCT02969187_exc_T57", "arg2_id": "NCT02969187_exc_T58", "normalized": [] } ]

[ { "id": "NCT02969187_inc_text", "type": "inclusion", "text": [ "Fulfills NIH criteria for bariatric surgery\nPlanned operation of laparoscopic Roux-en Y gastric bypass (LRYGB) or laparoscopic sleeve gastrectomy (LSG) as primary bariatric procedure\n" ], "offsets": [ [ 0, 183 ] ] } ]

[ { "id": "NCT02969187_inc_T1", "type": "Measurement", "text": [ "NIH criteria" ], "offsets": [ [ 9, 21 ] ], "normalized": [] }, { "id": "NCT02969187_inc_T2", "type": "Condition", "text": [ "bariatric surgery" ], "offsets": [ [ 26, 43 ] ], "normalized": [] }, { "id": "NCT02969187_inc_T3", "type": "Value", "text": [ "Fulfills" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT02969187_inc_T4", "type": "Procedure", "text": [ "laparoscopic Roux-en Y gastric bypass (LRYGB)" ], "offsets": [ [ 65, 110 ] ], "normalized": [] }, { "id": "NCT02969187_inc_T5", "type": "Procedure", "text": [ "laparoscopic sleeve gastrectomy (LSG)" ], "offsets": [ [ 114, 151 ] ], "normalized": [] }, { "id": "NCT02969187_inc_T6", "type": "Qualifier", "text": [ "primary" ], "offsets": [ [ 155, 162 ] ], "normalized": [] }, { "id": "NCT02969187_inc_T7", "type": "Scope", "text": [ "laparoscopic Roux-en Y gastric bypass (LRYGB) or laparoscopic sleeve gastrectomy (LSG)" ], "offsets": [ [ 65, 151 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02969187_inc_R1", "type": "Has_value", "arg1_id": "NCT02969187_inc_T1", "arg2_id": "NCT02969187_inc_T3", "normalized": [] }, { "id": "NCT02969187_inc_R2", "type": "AND", "arg1_id": "NCT02969187_inc_T2", "arg2_id": "NCT02969187_inc_T1", "normalized": [] }, { "id": "NCT02969187_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT02969187_inc_T7", "arg2_id": "NCT02969187_inc_T6", "normalized": [] } ]

[ { "id": "NCT02969876_exc_text", "type": "exclusion", "text": [ "NA\n\n" ], "offsets": [ [ 0, 4 ] ] } ]

[]

[]

[]

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[ { "id": "NCT02969876_inc_text", "type": "inclusion", "text": [ "Meets Diagnostic and Statistical Manual of Mental Disorders (Versions 4 and 5) criteria for and Major Depressive Disorder.\nHamilton Depression Rating Scale-17 score greater than 18.\nMen and women between ages >=18 and 65.\n" ], "offsets": [ [ 0, 222 ] ] } ]

[ { "id": "NCT02969876_inc_T1", "type": "Measurement", "text": [ "Diagnostic and Statistical Manual of Mental Disorders", "criteria" ], "offsets": [ [ 6, 59 ], [ 79, 87 ] ], "normalized": [] }, { "id": "NCT02969876_inc_T2", "type": "Qualifier", "text": [ "Versions 4" ], "offsets": [ [ 61, 71 ] ], "normalized": [] }, { "id": "NCT02969876_inc_T3", "type": "Qualifier", "text": [ "Versions", "5" ], "offsets": [ [ 61, 69 ], [ 76, 77 ] ], "normalized": [] }, { "id": "NCT02969876_inc_T5", "type": "Scope", "text": [ "Versions 4 and 5" ], "offsets": [ [ 61, 77 ] ], "normalized": [] }, { "id": "NCT02969876_inc_T6", "type": "Condition", "text": [ "Major Depressive Disorder" ], "offsets": [ [ 96, 121 ] ], "normalized": [] }, { "id": "NCT02969876_inc_T8", "type": "Measurement", "text": [ "Hamilton Depression Rating Scale" ], "offsets": [ [ 123, 155 ] ], "normalized": [] }, { "id": "NCT02969876_inc_T9", "type": "Value", "text": [ "greater than 18" ], "offsets": [ [ 165, 180 ] ], "normalized": [] }, { "id": "NCT02969876_inc_T10", "type": "Person", "text": [ "Men" ], "offsets": [ [ 182, 185 ] ], "normalized": [] }, { "id": "NCT02969876_inc_T11", "type": "Person", "text": [ "women" ], "offsets": [ [ 190, 195 ] ], "normalized": [] }, { "id": "NCT02969876_inc_T13", "type": "Person", "text": [ "ages" ], "offsets": [ [ 204, 208 ] ], "normalized": [] }, { "id": "NCT02969876_inc_T14", "type": "Value", "text": [ "tween a", " and 65" ], "offsets": [ [ 198, 205 ], [ 213, 220 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT02969876_inc_R1", "type": "Has_scope", "arg1_id": "NCT02969876_inc_T1", "arg2_id": "NCT02969876_inc_T5", "normalized": [] }, { "id": "NCT02969876_inc_R2", "type": "AND", "arg1_id": "NCT02969876_inc_T1", "arg2_id": "NCT02969876_inc_T6", "normalized": [] }, { "id": "NCT02969876_inc_R3", "type": "Has_value", "arg1_id": "NCT02969876_inc_T8", "arg2_id": "NCT02969876_inc_T9", "normalized": [] }, { "id": "NCT02969876_inc_R4", "type": "Has_value", "arg1_id": "NCT02969876_inc_T13", "arg2_id": "NCT02969876_inc_T14", "normalized": [] } ]

[ { "id": "NCT02970773_exc_text", "type": "exclusion", "text": [ "Any anti-coagulation therapy (apart from rivaroxaban for second objective)\nHypersensitivity or allergy to factor Xa inhibitors\nAcute bacterial endocarditis\nBleeding disorder\nClinically relevant active bleeding\nGastrointestinal ulcer or tumor\nHepatic dysfunction with increased bleeding risk\nRenal failure / patients undergoing dialysis\nPregnancy and breast feeding\nGastrectomy, biliopancreatic diversion, resection or re-routing of small intestines\nFeeding tube\nRecent blood donation\nAbnormalities of laboratory values: alanine-aminotransferase (ALAT), aspartate-aminotransferase (ASAT), gamma-glutamyl transferase (gammaGT), alkalic phosphatase (AP), bilirubin, amylase, lipase, cystatin C, creatinine, white blood cell count, haemoglobin, platelet count, prothrombin time, aPTT, fibrinogen, thrombin time, factors II,V,VII and X\nUse of therapeutic or recreational drugs influencing plasmatic coagulation\n" ], "offsets": [ [ 0, 906 ] ] } ]

[ { "id": "NCT02970773_exc_T1", "type": "Procedure", "text": [ "anti-coagulation therapy" ], "offsets": [ [ 4, 28 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T2", "type": "Drug", "text": [ "rivaroxaban" ], "offsets": [ [ 41, 52 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T3", "type": "Negation", "text": [ "apart from" ], "offsets": [ [ 30, 40 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T4", "type": "Condition", "text": [ "Hypersensitivity" ], "offsets": [ [ 75, 91 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T5", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 95, 102 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T6", "type": "Drug", "text": [ "factor Xa inhibitors" ], "offsets": [ [ 106, 126 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T7", "type": "Scope", "text": [ "Hypersensitivity or allergy" ], "offsets": [ [ 75, 102 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T8", "type": "Condition", "text": [ "Acute bacterial endocarditis" ], "offsets": [ [ 127, 155 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T9", "type": "Condition", "text": [ "Bleeding disorder" ], "offsets": [ [ 156, 173 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T10", "type": "Condition", "text": [ "active bleeding" ], "offsets": [ [ 194, 209 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T11", "type": "Condition", "text": [ "Gastrointestinal ulcer" ], "offsets": [ [ 210, 232 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T12", "type": "Condition", "text": [ "ointestinal ulce", "\nHep" ], "offsets": [ [ 215, 231 ], [ 241, 245 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T13", "type": "Condition", "text": [ "Hepatic dysfunction" ], "offsets": [ [ 242, 261 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T14", "type": "Observation", "text": [ "bleeding risk" ], "offsets": [ [ 277, 290 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T15", "type": "Qualifier", "text": [ "increased" ], "offsets": [ [ 267, 276 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T16", "type": "Condition", "text": [ "Renal failure" ], "offsets": [ [ 291, 304 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T17", "type": "Procedure", "text": [ "dialysis" ], "offsets": [ [ 327, 335 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T19", "type": "Procedure", "text": [ "Gastrectomy" ], "offsets": [ [ 365, 376 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T20", "type": "Procedure", "text": [ "biliopancreatic diversion" ], "offsets": [ [ 378, 403 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T21", "type": "Procedure", "text": [ "re-routing" ], "offsets": [ [ 418, 428 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T22", "type": "Procedure", "text": [ "resection" ], "offsets": [ [ 405, 414 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T23", "type": "Qualifier", "text": [ "small intestines" ], "offsets": [ [ 432, 448 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T24", "type": "Scope", "text": [ "resection or re-routing" ], "offsets": [ [ 405, 428 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T25", "type": "Device", "text": [ "Feeding tube" ], "offsets": [ [ 449, 461 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T26", "type": "Observation", "text": [ "blood donation" ], "offsets": [ [ 469, 483 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T27", "type": "Measurement", "text": [ "alanine-aminotransferase" ], "offsets": [ [ 520, 544 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T28", "type": "Measurement", "text": [ "ALAT" ], "offsets": [ [ 546, 550 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T29", "type": "Measurement", "text": [ "aspartate-aminotransferase" ], "offsets": [ [ 553, 579 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T30", "type": "Measurement", "text": [ "ASAT" ], "offsets": [ [ 581, 585 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T31", "type": "Measurement", "text": [ "gamma-glutamyl transferase" ], "offsets": [ [ 588, 614 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T32", "type": "Measurement", "text": [ "gammaGT" ], "offsets": [ [ 616, 623 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T33", "type": "Measurement", "text": [ "alkalic phosphatase" ], "offsets": [ [ 626, 645 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T34", "type": "Measurement", "text": [ "AP" ], "offsets": [ [ 647, 649 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T35", "type": "Measurement", "text": [ "bilirubin" ], "offsets": [ [ 652, 661 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T36", "type": "Measurement", "text": [ "amylase" ], "offsets": [ [ 663, 670 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T37", "type": "Measurement", "text": [ "lipase" ], "offsets": [ [ 672, 678 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T38", "type": "Measurement", "text": [ "cystatin C" ], "offsets": [ [ 680, 690 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T39", "type": "Measurement", "text": [ "creatinine" ], "offsets": [ [ 692, 702 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T40", "type": "Measurement", "text": [ "white blood cell count" ], "offsets": [ [ 704, 726 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T41", "type": "Measurement", "text": [ "haemoglobin" ], "offsets": [ [ 728, 739 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T42", "type": "Measurement", "text": [ "platelet count" ], "offsets": [ [ 741, 755 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T43", "type": "Measurement", "text": [ "prothrombin time," ], "offsets": [ [ 757, 774 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T44", "type": "Measurement", "text": [ "aPTT" ], "offsets": [ [ 775, 779 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T45", "type": "Measurement", "text": [ "fibrinogen" ], "offsets": [ [ 781, 791 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T46", "type": "Measurement", "text": [ "thrombin time" ], "offsets": [ [ 793, 806 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T47", "type": "Measurement", "text": [ "factors II" ], "offsets": [ [ 808, 818 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T48", "type": "Measurement", "text": [ ",VII an", "U" ], "offsets": [ [ 820, 827 ], [ 831, 832 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T49", "type": "Measurement", "text": [ ",VII an", "e o" ], "offsets": [ [ 820, 827 ], [ 833, 836 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T50", "type": "Measurement", "text": [ ",VII an", "r" ], "offsets": [ [ 820, 827 ], [ 841, 842 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T51", "type": "Scope", "text": [ "alanine-aminotransferase (ALAT), aspartate-aminotransferase (ASAT), gamma-glutamyl transferase (gammaGT), alkalic phosphatase (AP), bilirubin, amylase, lipase, cystatin C, creatinine, white blood cell count, haemoglobin, platelet count, prothrombin time, aPTT, fibrinogen, thrombin time, factors II,V,VII and X" ], "offsets": [ [ 520, 830 ] ], "normalized": [] }, { "id": "NCT02970773_exc_T52", "type": "Value", "text": [ "Abnormalities" ], "offsets": [ [ 484, 497 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02970773_exc_R1", "type": "Has_negation", "arg1_id": "NCT02970773_exc_T2", "arg2_id": "NCT02970773_exc_T3", "normalized": [] }, { "id": "NCT02970773_exc_R2", "type": "AND", "arg1_id": "NCT02970773_exc_T7", "arg2_id": "NCT02970773_exc_T6", "normalized": [] }, { "id": "NCT02970773_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02970773_exc_T14", "arg2_id": "NCT02970773_exc_T15", "normalized": [] }, { "id": "NCT02970773_exc_R4", "type": "AND", "arg1_id": "NCT02970773_exc_T14", "arg2_id": "NCT02970773_exc_T13", "normalized": [] }, { "id": "NCT02970773_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02970773_exc_T24", "arg2_id": "NCT02970773_exc_T23", "normalized": [] }, { "id": "NCT02970773_exc_R6", "type": "Subsumes", "arg1_id": "NCT02970773_exc_T27", "arg2_id": "NCT02970773_exc_T28", "normalized": [] }, { "id": "NCT02970773_exc_R7", "type": "Subsumes", "arg1_id": "NCT02970773_exc_T29", "arg2_id": "NCT02970773_exc_T30", "normalized": [] }, { "id": "NCT02970773_exc_R8", "type": "Subsumes", "arg1_id": "NCT02970773_exc_T31", "arg2_id": "NCT02970773_exc_T32", "normalized": [] }, { "id": "NCT02970773_exc_R9", "type": "Subsumes", "arg1_id": "NCT02970773_exc_T33", "arg2_id": "NCT02970773_exc_T34", "normalized": [] }, { "id": "NCT02970773_exc_R10", "type": "Has_value", "arg1_id": "NCT02970773_exc_T51", "arg2_id": "NCT02970773_exc_T52", "normalized": [] } ]

[ { "id": "NCT02970773_inc_text", "type": "inclusion", "text": [ "Motor complete tetraplegia for at least 3 months\nAge from 18 to 74 years\nBody mass index (BMI) from 18 to 35kg/m2\nInformed consent as documented by signature\n" ], "offsets": [ [ 0, 158 ] ] } ]

[ { "id": "NCT02970773_inc_T1", "type": "Condition", "text": [ "tetraplegia" ], "offsets": [ [ 15, 26 ] ], "normalized": [] }, { "id": "NCT02970773_inc_T2", "type": "Qualifier", "text": [ "complete" ], "offsets": [ [ 6, 14 ] ], "normalized": [] }, { "id": "NCT02970773_inc_T3", "type": "Temporal", "text": [ "at least 3 months" ], "offsets": [ [ 31, 48 ] ], "normalized": [] }, { "id": "NCT02970773_inc_T4", "type": "Person", "text": [ "Age" ], "offsets": [ [ 49, 52 ] ], "normalized": [] }, { "id": "NCT02970773_inc_T5", "type": "Value", "text": [ "from 18 to 74 years" ], "offsets": [ [ 53, 72 ] ], "normalized": [] }, { "id": "NCT02970773_inc_T6", "type": "Measurement", "text": [ "Body mass index" ], "offsets": [ [ 73, 88 ] ], "normalized": [] }, { "id": "NCT02970773_inc_T7", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 90, 93 ] ], "normalized": [] }, { "id": "NCT02970773_inc_T8", "type": "Value", "text": [ "from 18 to 35kg/m2" ], "offsets": [ [ 95, 113 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02970773_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT02970773_inc_T1", "arg2_id": "NCT02970773_inc_T2", "normalized": [] }, { "id": "NCT02970773_inc_R2", "type": "Has_temporal", "arg1_id": "NCT02970773_inc_T1", "arg2_id": "NCT02970773_inc_T3", "normalized": [] }, { "id": "NCT02970773_inc_R3", "type": "Has_value", "arg1_id": "NCT02970773_inc_T4", "arg2_id": "NCT02970773_inc_T5", "normalized": [] }, { "id": "NCT02970773_inc_R4", "type": "Subsumes", "arg1_id": "NCT02970773_inc_T6", "arg2_id": "NCT02970773_inc_T7", "normalized": [] }, { "id": "NCT02970773_inc_R5", "type": "Has_value", "arg1_id": "NCT02970773_inc_T6", "arg2_id": "NCT02970773_inc_T8", "normalized": [] } ]

[ { "id": "NCT02973035_exc_text", "type": "exclusion", "text": [ "Unwillingness or inability to comply with the procedures described in this protocol\nPlanned cardiac surgery or planned major non-cardiac surgery within the study period.\nStroke or coronary revascularization in the past 6 months.\nClinically significant pulmonary disease.\nUntreated hyperthyroidism, or hypothyroidism.\nA diagnosis of cancer (other than superficial squamous or basal cell skin cancer) in the past 3 years or current treatment for the active cancer.\nFemale of child-bearing potential who do not use adequate contraception and women who are pregnant or breast-feeding\nAny clinically significant abnormality identified at the screening visit, physical examination, laboratory tests, or electrocardiogram which, in the judgment of the Investigator, would preclude safe completion of the study.\nLV ejection fraction < 50%.\nSignificant renal disease manifested by serum creatinine > 2.5 mg/dL\nHepatic disease or biliary tract obstruction, or significant hepatic enzyme elevation (ALT or AST > 3 times upper limit of normal).\nHistory of intolerance to ARB or amlodipine.\nHypertrophic or restrictive cardiomyopathy.\nModerate or severe valvular disease.\nConstrictive pericarditis\nAtrial fibrillation with a heart rate > 120/min.\nSitting systolic BP < 100 mmHg\n" ], "offsets": [ [ 0, 1265 ] ] } ]

[ { "id": "NCT02973035_exc_T2", "type": "Temporal", "text": [ "within the study period" ], "offsets": [ [ 145, 168 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T3", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 137, 144 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T4", "type": "Qualifier", "text": [ "cardiac" ], "offsets": [ [ 129, 136 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T5", "type": "Negation", "text": [ "non" ], "offsets": [ [ 125, 128 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T6", "type": "Qualifier", "text": [ "major" ], "offsets": [ [ 119, 124 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T7", "type": "Mood", "text": [ "planned" ], "offsets": [ [ 111, 118 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T8", "type": "Procedure", "text": [ "cardiac surgery" ], "offsets": [ [ 92, 107 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T9", "type": "Mood", "text": [ "Planned" ], "offsets": [ [ 84, 91 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T10", "type": "Scope", "text": [ "Planned cardiac surgery or planned major non-cardiac surgery" ], "offsets": [ [ 84, 144 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T11", "type": "Reference_point", "text": [ "study period" ], "offsets": [ [ 156, 168 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T12", "type": "Procedure", "text": [ "coronary revascularization" ], "offsets": [ [ 180, 206 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T13", "type": "Procedure", "text": [ "roke o", "vascularization i" ], "offsets": [ [ 172, 178 ], [ 191, 208 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T14", "type": "Temporal", "text": [ "in the past 6 months" ], "offsets": [ [ 207, 227 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T15", "type": "Scope", "text": [ "Stroke or coronary revascularization" ], "offsets": [ [ 170, 206 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T16", "type": "Condition", "text": [ "pulmonary disease" ], "offsets": [ [ 252, 269 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T17", "type": "Qualifier", "text": [ "nically si", "nificant pu" ], "offsets": [ [ 232, 242 ], [ 243, 254 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T18", "type": "Condition", "text": [ "hyperthyroidism" ], "offsets": [ [ 281, 296 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T19", "type": "Condition", "text": [ "hypothyroidism" ], "offsets": [ [ 301, 315 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T20", "type": "Qualifier", "text": [ "Untreated" ], "offsets": [ [ 271, 280 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T21", "type": "Scope", "text": [ "hyperthyroidism, or hypothyroidism" ], "offsets": [ [ 281, 315 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T22", "type": "Condition", "text": [ "cancer" ], "offsets": [ [ 332, 338 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T23", "type": "Negation", "text": [ "other than" ], "offsets": [ [ 340, 350 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T24", "type": "Condition", "text": [ "ficial squamous or b", "cancer) in" ], "offsets": [ [ 356, 376 ], [ 391, 401 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T25", "type": "Condition", "text": [ "basal cell skin cancer" ], "offsets": [ [ 375, 397 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T26", "type": "Scope", "text": [ "superficial squamous or basal cell skin cancer" ], "offsets": [ [ 351, 397 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T27", "type": "Temporal", "text": [ "in the past 3 years" ], "offsets": [ [ 399, 418 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T28", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 430, 439 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T29", "type": "Condition", "text": [ "cancer" ], "offsets": [ [ 455, 461 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T30", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 448, 454 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T31", "type": "Scope", "text": [ "cancer (other than superficial squamous or basal cell skin cancer)" ], "offsets": [ [ 332, 398 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T34", "type": "Measurement", "text": [ "LV ejection fraction" ], "offsets": [ [ 804, 824 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T35", "type": "Value", "text": [ "< 50%" ], "offsets": [ [ 825, 830 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T36", "type": "Condition", "text": [ "renal disease" ], "offsets": [ [ 844, 857 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T37", "type": "Qualifier", "text": [ "Significant" ], "offsets": [ [ 832, 843 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T38", "type": "Measurement", "text": [ "serum creatinine" ], "offsets": [ [ 872, 888 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T39", "type": "Value", "text": [ "> 2.5 mg/dL" ], "offsets": [ [ 889, 900 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T40", "type": "Condition", "text": [ "Hepatic disease" ], "offsets": [ [ 901, 916 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T41", "type": "Condition", "text": [ "biliary tract obstruction" ], "offsets": [ [ 920, 945 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T42", "type": "Condition", "text": [ "hepatic enzyme elevation" ], "offsets": [ [ 962, 986 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T43", "type": "Qualifier", "text": [ "significant" ], "offsets": [ [ 950, 961 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T44", "type": "Measurement", "text": [ "ALT" ], "offsets": [ [ 988, 991 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T45", "type": "Measurement", "text": [ "AST" ], "offsets": [ [ 995, 998 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T46", "type": "Value", "text": [ "> 3 times upper limit of normal" ], "offsets": [ [ 999, 1030 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T47", "type": "Scope", "text": [ "ALT or AST" ], "offsets": [ [ 988, 998 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T48", "type": "Condition", "text": [ "intolerance" ], "offsets": [ [ 1044, 1055 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T49", "type": "Drug", "text": [ "ARB" ], "offsets": [ [ 1059, 1062 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T50", "type": "Drug", "text": [ "amlodipine" ], "offsets": [ [ 1066, 1076 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T51", "type": "Scope", "text": [ "ARB or amlodipine" ], "offsets": [ [ 1059, 1076 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T52", "type": "Condition", "text": [ "restrictive cardiomyopathy" ], "offsets": [ [ 1094, 1120 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T53", "type": "Condition", "text": [ " or restric", "hy.\nModerate o" ], "offsets": [ [ 1090, 1101 ], [ 1118, 1132 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T54", "type": "Condition", "text": [ "valvular disease" ], "offsets": [ [ 1141, 1157 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T55", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 1134, 1140 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T56", "type": "Qualifier", "text": [ "Moderate" ], "offsets": [ [ 1122, 1130 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T57", "type": "Scope", "text": [ "Moderate or severe" ], "offsets": [ [ 1122, 1140 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T58", "type": "Condition", "text": [ "Constrictive pericarditis" ], "offsets": [ [ 1159, 1184 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T59", "type": "Condition", "text": [ "Atrial fibrillation" ], "offsets": [ [ 1185, 1204 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T60", "type": "Measurement", "text": [ "heart rate" ], "offsets": [ [ 1212, 1222 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T61", "type": "Value", "text": [ "> 120/min" ], "offsets": [ [ 1223, 1232 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T62", "type": "Condition", "text": [ "systolic BP" ], "offsets": [ [ 1242, 1253 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T63", "type": "Qualifier", "text": [ "Sitting" ], "offsets": [ [ 1234, 1241 ] ], "normalized": [] }, { "id": "NCT02973035_exc_T64", "type": "Value", "text": [ "< 100 mmHg" ], "offsets": [ [ 1254, 1264 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02973035_exc_R1", "type": "Has_negation", "arg1_id": "NCT02973035_exc_T4", "arg2_id": "NCT02973035_exc_T5", "normalized": [] }, { "id": "NCT02973035_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02973035_exc_T3", "arg2_id": "NCT02973035_exc_T4", "normalized": [] }, { "id": "NCT02973035_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02973035_exc_T3", "arg2_id": "NCT02973035_exc_T6", "normalized": [] }, { "id": "NCT02973035_exc_R4", "type": "Has_mood", "arg1_id": "NCT02973035_exc_T3", "arg2_id": "NCT02973035_exc_T7", "normalized": [] }, { "id": "NCT02973035_exc_R5", "type": "Has_mood", "arg1_id": "NCT02973035_exc_T8", "arg2_id": "NCT02973035_exc_T9", "normalized": [] }, { "id": "NCT02973035_exc_R6", "type": "Has_temporal", "arg1_id": "NCT02973035_exc_T7", "arg2_id": "NCT02973035_exc_T2", "normalized": [] }, { "id": "NCT02973035_exc_R7", "type": "Has_index", "arg1_id": "NCT02973035_exc_T2", "arg2_id": "NCT02973035_exc_T11", "normalized": [] }, { "id": "NCT02973035_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02973035_exc_T15", "arg2_id": "NCT02973035_exc_T14", "normalized": [] }, { "id": "NCT02973035_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT02973035_exc_T16", "arg2_id": "NCT02973035_exc_T17", "normalized": [] }, { "id": "NCT02973035_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT02973035_exc_T21", "arg2_id": "NCT02973035_exc_T20", "normalized": [] }, { "id": "NCT02973035_exc_R11", "type": "Has_negation", "arg1_id": "NCT02973035_exc_T26", "arg2_id": "NCT02973035_exc_T23", "normalized": [] }, { "id": "NCT02973035_exc_R12", "type": "Has_qualifier", "arg1_id": "NCT02973035_exc_T29", "arg2_id": "NCT02973035_exc_T30", "normalized": [] }, { "id": "NCT02973035_exc_R13", "type": "AND", "arg1_id": "NCT02973035_exc_T28", "arg2_id": "NCT02973035_exc_T29", "normalized": [] }, { "id": "NCT02973035_exc_R14", "type": "Has_temporal", "arg1_id": "NCT02973035_exc_T31", "arg2_id": "NCT02973035_exc_T27", "normalized": [] }, { "id": "NCT02973035_exc_R15", "type": "Has_value", "arg1_id": "NCT02973035_exc_T34", "arg2_id": "NCT02973035_exc_T35", "normalized": [] }, { "id": "NCT02973035_exc_R16", "type": "Has_qualifier", "arg1_id": "NCT02973035_exc_T36", "arg2_id": "NCT02973035_exc_T37", "normalized": [] }, { "id": "NCT02973035_exc_R17", "type": "Has_value", "arg1_id": "NCT02973035_exc_T38", "arg2_id": "NCT02973035_exc_T39", "normalized": [] }, { "id": "NCT02973035_exc_R18", "type": "AND", "arg1_id": "NCT02973035_exc_T36", "arg2_id": "NCT02973035_exc_T38", "normalized": [] }, { "id": "NCT02973035_exc_R19", "type": "Has_qualifier", "arg1_id": "NCT02973035_exc_T42", "arg2_id": "NCT02973035_exc_T43", "normalized": [] }, { "id": "NCT02973035_exc_R20", "type": "Has_value", "arg1_id": "NCT02973035_exc_T47", "arg2_id": "NCT02973035_exc_T46", "normalized": [] }, { "id": "NCT02973035_exc_R21", "type": "Has_scope", "arg1_id": "NCT02973035_exc_T42", "arg2_id": "NCT02973035_exc_T47", "normalized": [] }, { "id": "NCT02973035_exc_R22", "type": "Has_scope", "arg1_id": "NCT02973035_exc_T48", "arg2_id": "NCT02973035_exc_T51", "normalized": [] }, { "id": "NCT02973035_exc_R23", "type": "Has_scope", "arg1_id": "NCT02973035_exc_T54", "arg2_id": "NCT02973035_exc_T57", "normalized": [] }, { "id": "NCT02973035_exc_R24", "type": "Has_value", "arg1_id": "NCT02973035_exc_T60", "arg2_id": "NCT02973035_exc_T61", "normalized": [] }, { "id": "NCT02973035_exc_R25", "type": "AND", "arg1_id": "NCT02973035_exc_T59", "arg2_id": "NCT02973035_exc_T60", "normalized": [] }, { "id": "NCT02973035_exc_R26", "type": "Has_qualifier", "arg1_id": "NCT02973035_exc_T62", "arg2_id": "NCT02973035_exc_T63", "normalized": [] }, { "id": "NCT02973035_exc_R27", "type": "Has_value", "arg1_id": "NCT02973035_exc_T62", "arg2_id": "NCT02973035_exc_T64", "normalized": [] } ]

[ { "id": "NCT02973035_inc_text", "type": "inclusion", "text": [ "Controlled hypertension: systolic BP < 150 and diastolic BP < 90 mmHg in persons aged 60 years or older, systolic BP < 140 and diastolic BP < 90 mmHg in persons 40 through 59 years according to the JNC 8th guideline\nEvidence of diastolic dysfunction showing E/E' > 10\nThe patient agrees to the study protocol and the schedule of clinical and echocardiographic follow-up, and provides informed, written consent, as approved by the appropriate Institutional Review Board/Ethical Committee of the respective clinical site\n" ], "offsets": [ [ 0, 519 ] ] } ]

[ { "id": "NCT02973035_inc_T1", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 11, 23 ] ], "normalized": [] }, { "id": "NCT02973035_inc_T2", "type": "Qualifier", "text": [ "Controlled" ], "offsets": [ [ 0, 10 ] ], "normalized": [] }, { "id": "NCT02973035_inc_T3", "type": "Measurement", "text": [ "systolic BP" ], "offsets": [ [ 25, 36 ] ], "normalized": [] }, { "id": "NCT02973035_inc_T4", "type": "Value", "text": [ "< 150" ], "offsets": [ [ 37, 42 ] ], "normalized": [] }, { "id": "NCT02973035_inc_T5", "type": "Measurement", "text": [ "diastolic BP" ], "offsets": [ [ 47, 59 ] ], "normalized": [] }, { "id": "NCT02973035_inc_T6", "type": "Value", "text": [ "< 90 mmHg" ], "offsets": [ [ 60, 69 ] ], "normalized": [] }, { "id": "NCT02973035_inc_T7", "type": "Person", "text": [ "aged" ], "offsets": [ [ 81, 85 ] ], "normalized": [] }, { "id": "NCT02973035_inc_T8", "type": "Value", "text": [ "60 years or older" ], "offsets": [ [ 86, 103 ] ], "normalized": [] }, { "id": "NCT02973035_inc_T9", "type": "Measurement", "text": [ "systolic BP" ], "offsets": [ [ 105, 116 ] ], "normalized": [] }, { "id": "NCT02973035_inc_T10", "type": "Value", "text": [ "< 140" ], "offsets": [ [ 117, 122 ] ], "normalized": [] }, { "id": "NCT02973035_inc_T11", "type": "Measurement", "text": [ "diastolic BP" ], "offsets": [ [ 127, 139 ] ], "normalized": [] }, { "id": "NCT02973035_inc_T12", "type": "Value", "text": [ "< 90 mmHg" ], "offsets": [ [ 140, 149 ] ], "normalized": [] }, { "id": "NCT02973035_inc_T13", "type": "Person", "text": [ "years" ], "offsets": [ [ 175, 180 ] ], "normalized": [] }, { "id": "NCT02973035_inc_T14", "type": "Value", "text": [ "40 through 59" ], "offsets": [ [ 161, 174 ] ], "normalized": [] }, { "id": "NCT02973035_inc_T15", "type": "Qualifier", "text": [ "JNC 8th guideline" ], "offsets": [ [ 198, 215 ] ], "normalized": [] }, { "id": "NCT02973035_inc_T16", "type": "Scope", "text": [ "systolic BP < 150 and diastolic BP < 90 mmHg in persons aged 60 years or older, systolic BP < 140 and diastolic BP < 90 mmHg in persons 40 through 59 years" ], "offsets": [ [ 25, 180 ] ], "normalized": [] }, { "id": "NCT02973035_inc_T17", "type": "Scope", "text": [ "systolic BP < 150 and diastolic BP < 90 mmHg" ], "offsets": [ [ 25, 69 ] ], "normalized": [] }, { "id": "NCT02973035_inc_T18", "type": "Scope", "text": [ "systolic BP < 140 and diastolic BP < 90 mmHg" ], "offsets": [ [ 105, 149 ] ], "normalized": [] }, { "id": "NCT02973035_inc_T19", "type": "Condition", "text": [ "diastolic dysfunction" ], "offsets": [ [ 228, 249 ] ], "normalized": [] }, { "id": "NCT02973035_inc_T20", "type": "Measurement", "text": [ "E/E'" ], "offsets": [ [ 258, 262 ] ], "normalized": [] }, { "id": "NCT02973035_inc_T21", "type": "Value", "text": [ "> 10" ], "offsets": [ [ 263, 267 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02973035_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT02973035_inc_T1", "arg2_id": "NCT02973035_inc_T2", "normalized": [] }, { "id": "NCT02973035_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02973035_inc_T1", "arg2_id": "NCT02973035_inc_T15", "normalized": [] }, { "id": "NCT02973035_inc_R3", "type": "Has_value", "arg1_id": "NCT02973035_inc_T3", "arg2_id": "NCT02973035_inc_T4", "normalized": [] }, { "id": "NCT02973035_inc_R4", "type": "Has_value", "arg1_id": "NCT02973035_inc_T5", "arg2_id": "NCT02973035_inc_T6", "normalized": [] }, { "id": "NCT02973035_inc_R5", "type": "Has_value", "arg1_id": "NCT02973035_inc_T7", "arg2_id": "NCT02973035_inc_T8", "normalized": [] }, { "id": "NCT02973035_inc_R6", "type": "Has_value", "arg1_id": "NCT02973035_inc_T9", "arg2_id": "NCT02973035_inc_T10", "normalized": [] }, { "id": "NCT02973035_inc_R7", "type": "Has_value", "arg1_id": "NCT02973035_inc_T11", "arg2_id": "NCT02973035_inc_T12", "normalized": [] }, { "id": "NCT02973035_inc_R8", "type": "AND", "arg1_id": "NCT02973035_inc_T14", "arg2_id": "NCT02973035_inc_T13", "normalized": [] }, { "id": "NCT02973035_inc_R9", "type": "Has_scope", "arg1_id": "NCT02973035_inc_T1", "arg2_id": "NCT02973035_inc_T16", "normalized": [] }, { "id": "NCT02973035_inc_R10", "type": "AND", "arg1_id": "NCT02973035_inc_T17", "arg2_id": "NCT02973035_inc_T7", "normalized": [] }, { "id": "NCT02973035_inc_R11", "type": "AND", "arg1_id": "NCT02973035_inc_T18", "arg2_id": "NCT02973035_inc_T13", "normalized": [] }, { "id": "NCT02973035_inc_R12", "type": "Has_value", "arg1_id": "NCT02973035_inc_T20", "arg2_id": "NCT02973035_inc_T21", "normalized": [] }, { "id": "NCT02973035_inc_R13", "type": "AND", "arg1_id": "NCT02973035_inc_T19", "arg2_id": "NCT02973035_inc_T20", "normalized": [] } ]

[ { "id": "NCT02974660_exc_text", "type": "exclusion", "text": [ "no consent\nperiprocedural complications requiring continuation of heparin or administration of protamine sulfate\nalergy to fish, protamine, protamine derivates, history of Humulin N, Novolin N, Novolin NPH, Gensulin N, SciLin N, NPH Iletin II and isophane insulin intake\n" ], "offsets": [ [ 0, 271 ] ] } ]

[ { "id": "NCT02974660_exc_T2", "type": "Condition", "text": [ "periprocedural complications" ], "offsets": [ [ 11, 39 ] ], "normalized": [] }, { "id": "NCT02974660_exc_T3", "type": "Drug", "text": [ "heparin" ], "offsets": [ [ 66, 73 ] ], "normalized": [] }, { "id": "NCT02974660_exc_T4", "type": "Drug", "text": [ "protamine sulfate" ], "offsets": [ [ 95, 112 ] ], "normalized": [] }, { "id": "NCT02974660_exc_T5", "type": "Mood", "text": [ "requiring" ], "offsets": [ [ 40, 49 ] ], "normalized": [] }, { "id": "NCT02974660_exc_T6", "type": "Scope", "text": [ "heparin or administration of protamine sulfate" ], "offsets": [ [ 66, 112 ] ], "normalized": [] }, { "id": "NCT02974660_exc_T7", "type": "Condition", "text": [ "alergy" ], "offsets": [ [ 113, 119 ] ], "normalized": [] }, { "id": "NCT02974660_exc_T8", "type": "Drug", "text": [ "fish" ], "offsets": [ [ 123, 127 ] ], "normalized": [] }, { "id": "NCT02974660_exc_T9", "type": "Drug", "text": [ "protamine" ], "offsets": [ [ 129, 138 ] ], "normalized": [] }, { "id": "NCT02974660_exc_T10", "type": "Drug", "text": [ "protamine derivates" ], "offsets": [ [ 140, 159 ] ], "normalized": [] }, { "id": "NCT02974660_exc_T11", "type": "Drug", "text": [ "Humulin N" ], "offsets": [ [ 172, 181 ] ], "normalized": [] }, { "id": "NCT02974660_exc_T12", "type": "Drug", "text": [ "Novolin N" ], "offsets": [ [ 183, 192 ] ], "normalized": [] }, { "id": "NCT02974660_exc_T13", "type": "Drug", "text": [ "Novolin NPH" ], "offsets": [ [ 194, 205 ] ], "normalized": [] }, { "id": "NCT02974660_exc_T14", "type": "Drug", "text": [ "Gensulin N" ], "offsets": [ [ 207, 217 ] ], "normalized": [] }, { "id": "NCT02974660_exc_T15", "type": "Drug", "text": [ "SciLin N" ], "offsets": [ [ 219, 227 ] ], "normalized": [] }, { "id": "NCT02974660_exc_T16", "type": "Drug", "text": [ "NPH Iletin II" ], "offsets": [ [ 229, 242 ] ], "normalized": [] }, { "id": "NCT02974660_exc_T17", "type": "Drug", "text": [ "isophane insulin" ], "offsets": [ [ 247, 263 ] ], "normalized": [] }, { "id": "NCT02974660_exc_T18", "type": "Scope", "text": [ "Humulin N, Novolin N, Novolin NPH, Gensulin N, SciLin N, NPH Iletin II and isophane insulin" ], "offsets": [ [ 172, 263 ] ], "normalized": [] }, { "id": "NCT02974660_exc_T19", "type": "Observation", "text": [ "history" ], "offsets": [ [ 161, 168 ] ], "normalized": [] }, { "id": "NCT02974660_exc_T20", "type": "Scope", "text": [ "fish, protamine, protamine derivates" ], "offsets": [ [ 123, 159 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02974660_exc_R1", "type": "Has_mood", "arg1_id": "NCT02974660_exc_T6", "arg2_id": "NCT02974660_exc_T5", "normalized": [] }, { "id": "NCT02974660_exc_R2", "type": "Has_scope", "arg1_id": "NCT02974660_exc_T2", "arg2_id": "NCT02974660_exc_T6", "normalized": [] }, { "id": "NCT02974660_exc_R3", "type": "Has_temporal", "arg1_id": "NCT02974660_exc_T18", "arg2_id": "NCT02974660_exc_T19", "normalized": [] }, { "id": "NCT02974660_exc_R4", "type": "Has_scope", "arg1_id": "NCT02974660_exc_T7", "arg2_id": "NCT02974660_exc_T20", "normalized": [] } ]

[ { "id": "NCT02974660_inc_text", "type": "inclusion", "text": [ "patients who underwent successful TAVI\nwith any approved TAVI device\nvia transfemoral access\nwith use of any of the approved vascular closure devices\nprovided written informed consent\n" ], "offsets": [ [ 0, 184 ] ] } ]

[ { "id": "NCT02974660_inc_T1", "type": "Procedure", "text": [ "TAVI" ], "offsets": [ [ 34, 38 ] ], "normalized": [] }, { "id": "NCT02974660_inc_T2", "type": "Qualifier", "text": [ "successful" ], "offsets": [ [ 23, 33 ] ], "normalized": [] }, { "id": "NCT02974660_inc_T3", "type": "Device", "text": [ "TAVI device" ], "offsets": [ [ 57, 68 ] ], "normalized": [] }, { "id": "NCT02974660_inc_T4", "type": "Procedure", "text": [ "transfemoral access" ], "offsets": [ [ 73, 92 ] ], "normalized": [] }, { "id": "NCT02974660_inc_T5", "type": "Device", "text": [ "vascular closure devices" ], "offsets": [ [ 125, 149 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02974660_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT02974660_inc_T1", "arg2_id": "NCT02974660_inc_T2", "normalized": [] } ]

[ { "id": "NCT02974686_exc_text", "type": "exclusion", "text": [ "Dual organ or kidney after another solid organ transplant\nPresence of a preexisting significant GI condition that does not have a presumed causal relationship with MPA\nEvidence of any GI disorder induced by an infection, underlying medical condition, or concomitant medication other than MPA\neGFR<40 ml/min at time of possible conversion\nProteinuria >1 gram/day at time of possible conversion\nHemoglobin <10 g/dL\nWBC <3 K/cumm\nPlatelets <100 K/cumm\nWound healing issues at time of possible conversion (eg, wound dehiscence, wound infection, incisional hernia, lymphocele, seroma)\nElevated total cholesterol (>350 mg/dL) and/or triglycerides (>500 ng/dL) at time of possible conversion\nHypersensitivity to everolimus, sirolimus, or other rapamycin deriviatives\n" ], "offsets": [ [ 0, 760 ] ] } ]

[ { "id": "NCT02974686_exc_T1", "type": "Procedure", "text": [ "solid organ transplant" ], "offsets": [ [ 35, 57 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T2", "type": "Condition", "text": [ "Dual organ" ], "offsets": [ [ 0, 10 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T3", "type": "Condition", "text": [ "Dual", "kidney" ], "offsets": [ [ 0, 4 ], [ 14, 20 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T4", "type": "Scope", "text": [ "Dual organ or kidney" ], "offsets": [ [ 0, 20 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T5", "type": "Condition", "text": [ "GI condition" ], "offsets": [ [ 96, 108 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T6", "type": "Temporal", "text": [ "preexisting" ], "offsets": [ [ 72, 83 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T7", "type": "Qualifier", "text": [ "significant" ], "offsets": [ [ 84, 95 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T8", "type": "Condition", "text": [ "GI disorder" ], "offsets": [ [ 184, 195 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T9", "type": "Qualifier", "text": [ "induced by an infection" ], "offsets": [ [ 196, 219 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T10", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 210, 219 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T11", "type": "Condition", "text": [ "underlying medical condition" ], "offsets": [ [ 221, 249 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T12", "type": "Drug", "text": [ "medication" ], "offsets": [ [ 266, 276 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T13", "type": "Drug", "text": [ "MPA" ], "offsets": [ [ 288, 291 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T14", "type": "Negation", "text": [ "other than" ], "offsets": [ [ 277, 287 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T15", "type": "Measurement", "text": [ "eGFR" ], "offsets": [ [ 292, 296 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T16", "type": "Value", "text": [ "<40 ml/min" ], "offsets": [ [ 296, 306 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T17", "type": "Temporal", "text": [ "at time of possible conversion" ], "offsets": [ [ 307, 337 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T18", "type": "Measurement", "text": [ "Proteinuria" ], "offsets": [ [ 338, 349 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T19", "type": "Value", "text": [ ">1 gram/day" ], "offsets": [ [ 350, 361 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T20", "type": "Temporal", "text": [ "at time of possible conversion" ], "offsets": [ [ 362, 392 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T21", "type": "Measurement", "text": [ "Hemoglobin" ], "offsets": [ [ 393, 403 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T22", "type": "Value", "text": [ "<10 g/dL" ], "offsets": [ [ 404, 412 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T23", "type": "Measurement", "text": [ "WBC" ], "offsets": [ [ 413, 416 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T24", "type": "Value", "text": [ "<3 K/cumm" ], "offsets": [ [ 417, 426 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T25", "type": "Measurement", "text": [ "Platelets" ], "offsets": [ [ 427, 436 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T26", "type": "Value", "text": [ "<100 K/cumm" ], "offsets": [ [ 437, 448 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T27", "type": "Condition", "text": [ "Wound healing issues" ], "offsets": [ [ 449, 469 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T28", "type": "Temporal", "text": [ "at time of possible conversion" ], "offsets": [ [ 470, 500 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T29", "type": "Condition", "text": [ "wound dehiscence" ], "offsets": [ [ 506, 522 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T30", "type": "Condition", "text": [ "wound infection" ], "offsets": [ [ 524, 539 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T31", "type": "Condition", "text": [ "incisional hernia" ], "offsets": [ [ 541, 558 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T32", "type": "Condition", "text": [ "lymphocele" ], "offsets": [ [ 560, 570 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T33", "type": "Condition", "text": [ "seroma" ], "offsets": [ [ 572, 578 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T34", "type": "Scope", "text": [ "wound dehiscence, wound infection, incisional hernia, lymphocele, seroma" ], "offsets": [ [ 506, 578 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T35", "type": "Measurement", "text": [ "total cholesterol" ], "offsets": [ [ 589, 606 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T36", "type": "Value", "text": [ "Elevated" ], "offsets": [ [ 580, 588 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T37", "type": "Value", "text": [ ">350 mg/dL" ], "offsets": [ [ 608, 618 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T38", "type": "Measurement", "text": [ "triglycerides" ], "offsets": [ [ 627, 640 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T39", "type": "Value", "text": [ ">500 ng/dL" ], "offsets": [ [ 642, 652 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T40", "type": "Temporal", "text": [ "at time of possible conversion" ], "offsets": [ [ 654, 684 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T41", "type": "Condition", "text": [ "Hypersensitivity" ], "offsets": [ [ 685, 701 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T42", "type": "Drug", "text": [ "everolimus" ], "offsets": [ [ 705, 715 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T43", "type": "Drug", "text": [ "sirolimus" ], "offsets": [ [ 717, 726 ] ], "normalized": [] }, { "id": "NCT02974686_exc_T44", "type": "Drug", "text": [ "rapamycin" ], "offsets": [ [ 737, 746 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02974686_exc_R1", "type": "AND", "arg1_id": "NCT02974686_exc_T4", "arg2_id": "NCT02974686_exc_T1", "normalized": [] }, { "id": "NCT02974686_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02974686_exc_T5", "arg2_id": "NCT02974686_exc_T7", "normalized": [] }, { "id": "NCT02974686_exc_R3", "type": "Has_temporal", "arg1_id": "NCT02974686_exc_T5", "arg2_id": "NCT02974686_exc_T6", "normalized": [] }, { "id": "NCT02974686_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02974686_exc_T8", "arg2_id": "NCT02974686_exc_T9", "normalized": [] }, { "id": "NCT02974686_exc_R6", "type": "Has_negation", "arg1_id": "NCT02974686_exc_T13", "arg2_id": "NCT02974686_exc_T14", "normalized": [] }, { "id": "NCT02974686_exc_R7", "type": "AND", "arg1_id": "NCT02974686_exc_T12", "arg2_id": "NCT02974686_exc_T13", "normalized": [] }, { "id": "NCT02974686_exc_R8", "type": "Has_value", "arg1_id": "NCT02974686_exc_T15", "arg2_id": "NCT02974686_exc_T16", "normalized": [] }, { "id": "NCT02974686_exc_R9", "type": "Has_temporal", "arg1_id": "NCT02974686_exc_T15", "arg2_id": "NCT02974686_exc_T17", "normalized": [] }, { "id": "NCT02974686_exc_R10", "type": "Has_value", "arg1_id": "NCT02974686_exc_T18", "arg2_id": "NCT02974686_exc_T19", "normalized": [] }, { "id": "NCT02974686_exc_R11", "type": "Has_temporal", "arg1_id": "NCT02974686_exc_T18", "arg2_id": "NCT02974686_exc_T20", "normalized": [] }, { "id": "NCT02974686_exc_R12", "type": "Has_value", "arg1_id": "NCT02974686_exc_T21", "arg2_id": "NCT02974686_exc_T22", "normalized": [] }, { "id": "NCT02974686_exc_R13", "type": "Has_value", "arg1_id": "NCT02974686_exc_T23", "arg2_id": "NCT02974686_exc_T24", "normalized": [] }, { "id": "NCT02974686_exc_R14", "type": "Has_value", "arg1_id": "NCT02974686_exc_T25", "arg2_id": "NCT02974686_exc_T26", "normalized": [] }, { "id": "NCT02974686_exc_R15", "type": "Has_temporal", "arg1_id": "NCT02974686_exc_T27", "arg2_id": "NCT02974686_exc_T28", "normalized": [] }, { "id": "NCT02974686_exc_R16", "type": "Has_scope", "arg1_id": "NCT02974686_exc_T27", "arg2_id": "NCT02974686_exc_T34", "normalized": [] }, { "id": "NCT02974686_exc_R17", "type": "Has_value", "arg1_id": "NCT02974686_exc_T35", "arg2_id": "NCT02974686_exc_T36", "normalized": [] }, { "id": "NCT02974686_exc_R18", "type": "Subsumes", "arg1_id": "NCT02974686_exc_T36", "arg2_id": "NCT02974686_exc_T37", "normalized": [] }, { "id": "NCT02974686_exc_R19", "type": "Has_value", "arg1_id": "NCT02974686_exc_T38", "arg2_id": "NCT02974686_exc_T39", "normalized": [] }, { "id": "NCT02974686_exc_R20", "type": "Has_temporal", "arg1_id": "NCT02974686_exc_T38", "arg2_id": "NCT02974686_exc_T40", "normalized": [] } ]

[ { "id": "NCT02974686_inc_text", "type": "inclusion", "text": [ "Kidney transplant recipients at Washington University/Barnes-Jewish Hospital\nExperiencing GI toxicity from MPA as determined by the treating physician within 12 months post-renal transplant\nOn standard immunosuppression with tacrolimus and prednisone\n" ], "offsets": [ [ 0, 251 ] ] } ]

[ { "id": "NCT02974686_inc_T1", "type": "Procedure", "text": [ "Kidney transplant" ], "offsets": [ [ 0, 17 ] ], "normalized": [] }, { "id": "NCT02974686_inc_T2", "type": "Visit", "text": [ "Washington University/Barnes-Jewish Hospital" ], "offsets": [ [ 32, 76 ] ], "normalized": [] }, { "id": "NCT02974686_inc_T3", "type": "Procedure", "text": [ "GI toxicity" ], "offsets": [ [ 90, 101 ] ], "normalized": [] }, { "id": "NCT02974686_inc_T4", "type": "Drug", "text": [ "MPA" ], "offsets": [ [ 107, 110 ] ], "normalized": [] }, { "id": "NCT02974686_inc_T5", "type": "Procedure", "text": [ "standard immunosuppression" ], "offsets": [ [ 193, 219 ] ], "normalized": [] }, { "id": "NCT02974686_inc_T6", "type": "Drug", "text": [ "tacrolimus" ], "offsets": [ [ 225, 235 ] ], "normalized": [] }, { "id": "NCT02974686_inc_T7", "type": "Drug", "text": [ "prednison" ], "offsets": [ [ 240, 249 ] ], "normalized": [] }, { "id": "NCT02974686_inc_T8", "type": "Scope", "text": [ "tacrolimus and prednison" ], "offsets": [ [ 225, 249 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02974686_inc_R1", "type": "AND", "arg1_id": "NCT02974686_inc_T1", "arg2_id": "NCT02974686_inc_T2", "normalized": [] }, { "id": "NCT02974686_inc_R2", "type": "AND", "arg1_id": "NCT02974686_inc_T3", "arg2_id": "NCT02974686_inc_T4", "normalized": [] }, { "id": "NCT02974686_inc_R3", "type": "Has_scope", "arg1_id": "NCT02974686_inc_T5", "arg2_id": "NCT02974686_inc_T8", "normalized": [] } ]

[ { "id": "NCT02979561_exc_text", "type": "exclusion", "text": [ "Signs of hemodynamic instability (i.e. systolic blood pressure <100 mm Hg.St. or episode of systolic blood pressure fall for =40 mm Hg. / or heart rate > 110 lasting more than 15 min) or need for ventilatory support within 12 hours prior to randomisation.\nThe indication for oral anticoagulation, associated with others disease.\nmalignant neoplasm of any location\nContraindications to warfarin or pradaxa according to Russian Instructions for medical use of these drugs\nIndications for concomitant treatment with antiplatelet agents\nAny stroke within 6 months before randomization\nIntracranial hemorrhage in anamnesis\nActive bleeding, bleeding diathesis.\nClinically significant bleeding within the last 30 days.\nTrauma or extensive surgery within 1 month before randomization or surgery planned in the next 6 months after randomization.\nIntracranial pathology: tumor, arteriovenous fistula or aneurysm.\nGastrointestinal bleeding in the previous 3 months.\nGastric ulcer or duodenal ulcer with clinical manifestations or endoscopically identified acute ulcer without signs of scarring during previous 30 days.\nUncontrolled hypertension (systolic blood pressure> 180 mm Hg. and / or diastolic blood pressure> 100 mm.hg in patients receiving antihypertensive drugs).\nPregnancy, lactation.\nLife expectancy <6 months.\nClinically significant liver disease.\nCreatinine clearance (estimated by Cockcroft-Gault) <30 ml / min.\nhemoglobin level <90 g/l), thrombocytopenia <100x10^9 / L.\nPatients who, in the opinion of the researcher, are not suitable for inclusion in the study, for example, due to the low likelihood of doctor's recommendations following.\nLong-term use of NSAIDs\nCurrent participation in another clinical study.\nAllergic to contrast substance or radioisotope drugs used in procedures to assess endpoints of the study, which according to researchers, may be a contraindication to the implementation of these research methods.\n" ], "offsets": [ [ 0, 1932 ] ] } ]

[ { "id": "NCT02979561_exc_T1", "type": "Condition", "text": [ "hemodynamic instability" ], "offsets": [ [ 9, 32 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T2", "type": "Measurement", "text": [ "systolic blood pressure" ], "offsets": [ [ 39, 62 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T3", "type": "Value", "text": [ "<100 mm Hg.St." ], "offsets": [ [ 63, 77 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T4", "type": "Measurement", "text": [ "systolic blood pressure fall" ], "offsets": [ [ 92, 120 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T5", "type": "Value", "text": [ "=40 mm Hg" ], "offsets": [ [ 125, 134 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T6", "type": "Measurement", "text": [ "heart rate" ], "offsets": [ [ 141, 151 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T7", "type": "Value", "text": [ "> 110" ], "offsets": [ [ 152, 157 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T8", "type": "Multiplier", "text": [ "lasting more than 15 min" ], "offsets": [ [ 158, 182 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T9", "type": "Procedure", "text": [ "ventilatory support" ], "offsets": [ [ 196, 215 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T10", "type": "Mood", "text": [ "need for" ], "offsets": [ [ 187, 195 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T11", "type": "Temporal", "text": [ "within 12 hours prior to randomisation" ], "offsets": [ [ 216, 254 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T12", "type": "Scope", "text": [ "systolic blood pressure <100 mm Hg.St. or episode of systolic blood pressure fall for =40 mm Hg. / or heart rate > 110 lasting more than 15 min" ], "offsets": [ [ 39, 182 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T13", "type": "Procedure", "text": [ "oral anticoagulation" ], "offsets": [ [ 275, 295 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T14", "type": "Mood", "text": [ "indication for" ], "offsets": [ [ 260, 274 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T15", "type": "Qualifier", "text": [ "malignant" ], "offsets": [ [ 329, 338 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T16", "type": "Condition", "text": [ "neoplasm" ], "offsets": [ [ 339, 347 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T17", "type": "Condition", "text": [ "Contraindications" ], "offsets": [ [ 364, 381 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T18", "type": "Drug", "text": [ "warfarin" ], "offsets": [ [ 385, 393 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T19", "type": "Drug", "text": [ "pradaxa" ], "offsets": [ [ 397, 404 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T20", "type": "Scope", "text": [ "warfarin or pradaxa" ], "offsets": [ [ 385, 404 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T21", "type": "Qualifier", "text": [ "Russian Instructions for medical use" ], "offsets": [ [ 418, 454 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T22", "type": "Drug", "text": [ "antiplatelet agents" ], "offsets": [ [ 513, 532 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T23", "type": "Temporal", "text": [ "concomitant" ], "offsets": [ [ 486, 497 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T24", "type": "Mood", "text": [ "Indications" ], "offsets": [ [ 470, 481 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T25", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 537, 543 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T26", "type": "Temporal", "text": [ "within 6 months before randomization" ], "offsets": [ [ 544, 580 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T27", "type": "Condition", "text": [ "Intracranial hemorrhage" ], "offsets": [ [ 581, 604 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T28", "type": "Procedure", "text": [ "anamnesis" ], "offsets": [ [ 608, 617 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T29", "type": "Condition", "text": [ "bleeding" ], "offsets": [ [ 635, 643 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T30", "type": "Condition", "text": [ "bleeding diathesis" ], "offsets": [ [ 635, 653 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T31", "type": "Qualifier", "text": [ "Clinically significant" ], "offsets": [ [ 655, 677 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T32", "type": "Condition", "text": [ "bleeding" ], "offsets": [ [ 678, 686 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T33", "type": "Temporal", "text": [ "within the last 30 days" ], "offsets": [ [ 687, 710 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T34", "type": "Condition", "text": [ "Trauma" ], "offsets": [ [ 712, 718 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T35", "type": "Procedure", "text": [ "extensive surgery" ], "offsets": [ [ 722, 739 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T36", "type": "Temporal", "text": [ "within 1 month before randomization" ], "offsets": [ [ 740, 775 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T37", "type": "Scope", "text": [ "Trauma or extensive surgery" ], "offsets": [ [ 712, 739 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T38", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 779, 786 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T39", "type": "Mood", "text": [ "planned" ], "offsets": [ [ 787, 794 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T40", "type": "Temporal", "text": [ "in the next 6 months after randomization" ], "offsets": [ [ 795, 835 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T41", "type": "Condition", "text": [ "Intracranial pathology" ], "offsets": [ [ 837, 859 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T42", "type": "Condition", "text": [ "tumor" ], "offsets": [ [ 861, 866 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T43", "type": "Condition", "text": [ "arteriovenous fistula" ], "offsets": [ [ 868, 889 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T44", "type": "Condition", "text": [ "aneurysm" ], "offsets": [ [ 893, 901 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T45", "type": "Scope", "text": [ "tumor, arteriovenous fistula or aneurysm" ], "offsets": [ [ 861, 901 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T46", "type": "Condition", "text": [ "Gastrointestinal bleeding" ], "offsets": [ [ 903, 928 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T47", "type": "Temporal", "text": [ "in the previous 3 months" ], "offsets": [ [ 929, 953 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T48", "type": "Condition", "text": [ "Gastric ulcer" ], "offsets": [ [ 955, 968 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T49", "type": "Condition", "text": [ "duodenal ulcer" ], "offsets": [ [ 972, 986 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T50", "type": "Condition", "text": [ "clinical manifestations" ], "offsets": [ [ 992, 1015 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T51", "type": "Qualifier", "text": [ "endoscopically identified" ], "offsets": [ [ 1019, 1044 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T52", "type": "Procedure", "text": [ "endoscopically" ], "offsets": [ [ 1019, 1033 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T53", "type": "Condition", "text": [ "acute ulcer" ], "offsets": [ [ 1045, 1056 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T54", "type": "Negation", "text": [ "without" ], "offsets": [ [ 1057, 1064 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T55", "type": "Condition", "text": [ "signs of scarring" ], "offsets": [ [ 1065, 1082 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T56", "type": "Temporal", "text": [ "during previous 30 days" ], "offsets": [ [ 1083, 1106 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T57", "type": "Qualifier", "text": [ "Uncontrolled" ], "offsets": [ [ 1108, 1120 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T58", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 1121, 1133 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T59", "type": "Measurement", "text": [ "systolic blood pressure" ], "offsets": [ [ 1135, 1158 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T60", "type": "Value", "text": [ "> 180 mm Hg" ], "offsets": [ [ 1158, 1169 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T61", "type": "Measurement", "text": [ "diastolic blood pressure" ], "offsets": [ [ 1180, 1204 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T62", "type": "Value", "text": [ "> 100 mm.hg" ], "offsets": [ [ 1204, 1215 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T63", "type": "Drug", "text": [ "antihypertensive drugs" ], "offsets": [ [ 1238, 1260 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T64", "type": "Scope", "text": [ "systolic blood pressure> 180 mm Hg. and / or diastolic blood pressure> 100 mm.hg in patients receiving antihypertensive drugs" ], "offsets": [ [ 1135, 1260 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T65", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 1263, 1272 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T66", "type": "Condition", "text": [ "lactation" ], "offsets": [ [ 1274, 1283 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T67", "type": "Observation", "text": [ "Life expectancy" ], "offsets": [ [ 1285, 1300 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T68", "type": "Value", "text": [ "<6 months" ], "offsets": [ [ 1301, 1310 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T69", "type": "Qualifier", "text": [ "Clinically significant" ], "offsets": [ [ 1312, 1334 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T70", "type": "Condition", "text": [ "liver disease" ], "offsets": [ [ 1335, 1348 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T71", "type": "Measurement", "text": [ "Creatinine clearance" ], "offsets": [ [ 1350, 1370 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T72", "type": "Qualifier", "text": [ "Cockcroft-Gault" ], "offsets": [ [ 1385, 1400 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T73", "type": "Value", "text": [ "<30 ml / min" ], "offsets": [ [ 1402, 1414 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T74", "type": "Measurement", "text": [ "hemoglobin level" ], "offsets": [ [ 1416, 1432 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T75", "type": "Value", "text": [ "<90 g/l" ], "offsets": [ [ 1433, 1440 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T76", "type": "Condition", "text": [ "thrombocytopenia" ], "offsets": [ [ 1443, 1459 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T77", "type": "Value", "text": [ "<100x10^9 / L" ], "offsets": [ [ 1460, 1473 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T79", "type": "Drug", "text": [ "NSAIDs" ], "offsets": [ [ 1663, 1669 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T80", "type": "Multiplier", "text": [ "Long-term use" ], "offsets": [ [ 1646, 1659 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T82", "type": "Condition", "text": [ "Allergic" ], "offsets": [ [ 1719, 1727 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T83", "type": "Drug", "text": [ "contrast substance" ], "offsets": [ [ 1731, 1749 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T84", "type": "Drug", "text": [ "radioisotope drugs" ], "offsets": [ [ 1753, 1771 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T85", "type": "Scope", "text": [ "contrast substance or radioisotope drugs" ], "offsets": [ [ 1731, 1771 ] ], "normalized": [] }, { "id": "NCT02979561_exc_T86", "type": "Qualifier", "text": [ "Active" ], "offsets": [ [ 618, 624 ] ], "normalized": [] } ]

[]

[]

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"type": "Has_mood", "arg1_id": "NCT02979561_exc_T13", "arg2_id": "NCT02979561_exc_T14", "normalized": [] }, { "id": "NCT02979561_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT02979561_exc_T16", "arg2_id": "NCT02979561_exc_T15", "normalized": [] }, { "id": "NCT02979561_exc_R10", "type": "Has_scope", "arg1_id": "NCT02979561_exc_T17", "arg2_id": "NCT02979561_exc_T20", "normalized": [] }, { "id": "NCT02979561_exc_R11", "type": "Has_qualifier", "arg1_id": "NCT02979561_exc_T17", "arg2_id": "NCT02979561_exc_T21", "normalized": [] }, { "id": "NCT02979561_exc_R12", "type": "Has_mood", "arg1_id": "NCT02979561_exc_T22", "arg2_id": "NCT02979561_exc_T24", "normalized": [] }, { "id": "NCT02979561_exc_R13", "type": "Has_temporal", "arg1_id": "NCT02979561_exc_T22", "arg2_id": "NCT02979561_exc_T23", "normalized": [] }, { "id": "NCT02979561_exc_R14", "type": "Has_temporal", "arg1_id": "NCT02979561_exc_T25", "arg2_id": "NCT02979561_exc_T26", "normalized": [] }, { "id": "NCT02979561_exc_R15", "type": "AND", "arg1_id": "NCT02979561_exc_T28", "arg2_id": "NCT02979561_exc_T27", "normalized": [] }, { "id": "NCT02979561_exc_R16", "type": "Has_qualifier", "arg1_id": "NCT02979561_exc_T32", "arg2_id": "NCT02979561_exc_T31", "normalized": [] }, { "id": "NCT02979561_exc_R17", "type": "Has_temporal", "arg1_id": "NCT02979561_exc_T32", "arg2_id": "NCT02979561_exc_T33", "normalized": [] }, { "id": "NCT02979561_exc_R18", "type": "Has_temporal", "arg1_id": "NCT02979561_exc_T37", "arg2_id": "NCT02979561_exc_T36", "normalized": [] }, { "id": "NCT02979561_exc_R19", "type": "Has_temporal", "arg1_id": "NCT02979561_exc_T38", "arg2_id": "NCT02979561_exc_T40", "normalized": [] }, { "id": "NCT02979561_exc_R20", "type": "Has_mood", "arg1_id": "NCT02979561_exc_T38", "arg2_id": "NCT02979561_exc_T39", "normalized": [] }, { "id": "NCT02979561_exc_R21", "type": "Subsumes", "arg1_id": "NCT02979561_exc_T41", "arg2_id": "NCT02979561_exc_T45", "normalized": [] }, { "id": "NCT02979561_exc_R22", "type": "Has_temporal", "arg1_id": "NCT02979561_exc_T46", "arg2_id": "NCT02979561_exc_T47", "normalized": [] }, { "id": "NCT02979561_exc_R23", "type": "AND", "arg1_id": "NCT02979561_exc_T49", "arg2_id": "NCT02979561_exc_T50", "normalized": [] }, { "id": "NCT02979561_exc_R24", "type": "Has_negation", "arg1_id": "NCT02979561_exc_T55", "arg2_id": "NCT02979561_exc_T54", "normalized": [] }, { "id": "NCT02979561_exc_R25", "type": "Has_qualifier", "arg1_id": "NCT02979561_exc_T53", "arg2_id": "NCT02979561_exc_T51", "normalized": [] }, { "id": "NCT02979561_exc_R27", "type": "AND", "arg1_id": "NCT02979561_exc_T53", "arg2_id": "NCT02979561_exc_T55", "normalized": [] }, { "id": "NCT02979561_exc_R28", "type": "Has_temporal", "arg1_id": "NCT02979561_exc_T53", "arg2_id": "NCT02979561_exc_T56", "normalized": [] }, { "id": "NCT02979561_exc_R29", "type": "Has_value", "arg1_id": "NCT02979561_exc_T59", "arg2_id": "NCT02979561_exc_T60", "normalized": [] }, { "id": "NCT02979561_exc_R30", "type": "Has_value", "arg1_id": "NCT02979561_exc_T61", "arg2_id": "NCT02979561_exc_T62", "normalized": [] }, { "id": "NCT02979561_exc_R31", "type": "Has_qualifier", "arg1_id": "NCT02979561_exc_T58", "arg2_id": "NCT02979561_exc_T57", "normalized": [] }, { "id": "NCT02979561_exc_R32", "type": "Subsumes", "arg1_id": "NCT02979561_exc_T58", "arg2_id": "NCT02979561_exc_T64", "normalized": [] }, { "id": "NCT02979561_exc_R33", "type": "Has_value", "arg1_id": "NCT02979561_exc_T67", "arg2_id": "NCT02979561_exc_T68", "normalized": [] }, { "id": "NCT02979561_exc_R34", "type": "Has_qualifier", "arg1_id": "NCT02979561_exc_T70", "arg2_id": "NCT02979561_exc_T69", "normalized": [] }, { "id": "NCT02979561_exc_R35", "type": "Has_qualifier", "arg1_id": "NCT02979561_exc_T71", "arg2_id": "NCT02979561_exc_T72", "normalized": [] }, { "id": "NCT02979561_exc_R36", "type": "Has_value", "arg1_id": "NCT02979561_exc_T71", "arg2_id": "NCT02979561_exc_T73", "normalized": [] }, { "id": "NCT02979561_exc_R37", "type": "Has_value", "arg1_id": "NCT02979561_exc_T74", "arg2_id": "NCT02979561_exc_T75", "normalized": [] }, { "id": "NCT02979561_exc_R38", "type": "Has_value", "arg1_id": "NCT02979561_exc_T76", "arg2_id": "NCT02979561_exc_T77", "normalized": [] }, { "id": "NCT02979561_exc_R39", "type": "Has_multiplier", "arg1_id": "NCT02979561_exc_T79", "arg2_id": "NCT02979561_exc_T80", "normalized": [] }, { "id": "NCT02979561_exc_R40", "type": "Has_scope", "arg1_id": "NCT02979561_exc_T82", "arg2_id": "NCT02979561_exc_T85", "normalized": [] }, { "id": "NCT02979561_exc_R41", "type": "Has_qualifier", "arg1_id": "NCT02979561_exc_T29", "arg2_id": "NCT02979561_exc_T86", "normalized": [] } ]

[ { "id": "NCT02979561_inc_text", "type": "inclusion", "text": [ "Men and women aged > 18 years\nAngiographically confirmed acute massive pulmonary embolism with involvement of Central pulmonary arteries.\nendovascular mechanical thrombus fragmentation + thrombolytic therapy (using recombinant tissue activator of plasminogen), performed for treatment of the above-mentioned pulmonary embolism in less than 48 hours before randomization. The patient should be randomized no earlier than 24 hours after procedures endovascular mechanical thrombus fragmentation + thrombolytic therapy\nWritten informed consent signed by patient.\n" ], "offsets": [ [ 0, 560 ] ] } ]

[ { "id": "NCT02979561_inc_T1", "type": "Person", "text": [ "Men" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02979561_inc_T2", "type": "Person", "text": [ "women" ], "offsets": [ [ 8, 13 ] ], "normalized": [] }, { "id": "NCT02979561_inc_T3", "type": "Person", "text": [ "aged" ], "offsets": [ [ 14, 18 ] ], "normalized": [] }, { "id": "NCT02979561_inc_T4", "type": "Value", "text": [ "> 18 years" ], "offsets": [ [ 19, 29 ] ], "normalized": [] }, { "id": "NCT02979561_inc_T5", "type": "Procedure", "text": [ "Angiographically" ], "offsets": [ [ 30, 46 ] ], "normalized": [] }, { "id": "NCT02979561_inc_T6", "type": "Qualifier", "text": [ "Angiographically confirmed" ], "offsets": [ [ 30, 56 ] ], "normalized": [] }, { "id": "NCT02979561_inc_T7", "type": "Qualifier", "text": [ "acute" ], "offsets": [ [ 57, 62 ] ], "normalized": [] }, { "id": "NCT02979561_inc_T8", "type": "Qualifier", "text": [ "massive" ], "offsets": [ [ 63, 70 ] ], "normalized": [] }, { "id": "NCT02979561_inc_T9", "type": "Condition", "text": [ "pulmonary embolism" ], "offsets": [ [ 71, 89 ] ], "normalized": [] }, { "id": "NCT02979561_inc_T10", "type": "Condition", "text": [ "involvement of Central pulmonary arteries" ], "offsets": [ [ 95, 136 ] ], "normalized": [] }, { "id": "NCT02979561_inc_T11", "type": "Condition", "text": [ "endovascular mechanical thrombus fragmentation" ], "offsets": [ [ 138, 184 ] ], "normalized": [] }, { "id": "NCT02979561_inc_T12", "type": "Procedure", "text": [ "thrombolytic therapy" ], "offsets": [ [ 187, 207 ] ], "normalized": [] }, { "id": "NCT02979561_inc_T13", "type": "Drug", "text": [ "recombinant tissue activator of plasminogen" ], "offsets": [ [ 215, 258 ] ], "normalized": [] }, { "id": "NCT02979561_inc_T14", "type": "Temporal", "text": [ "in less than 48 hours before randomization" ], "offsets": [ [ 327, 369 ] ], "normalized": [] }, { "id": "NCT02979561_inc_T15", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 275, 284 ] ], "normalized": [] }, { "id": "NCT02979561_inc_T16", "type": "Condition", "text": [ "pulmonary embolism" ], "offsets": [ [ 308, 326 ] ], "normalized": [] }, { "id": "NCT02979561_inc_T17", "type": "Scope", "text": [ "endovascular mechanical thrombus fragmentation + thrombolytic therapy (using recombinant tissue activator of plasminogen)" ], "offsets": [ [ 138, 259 ] ], "normalized": [] } ]

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