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BigScience Biomedical Datasets 131

[ { "id": "NCT02748330_exc_text", "type": "exclusion", "text": [ "NA\n\n" ], "offsets": [ [ 0, 4 ] ] } ]

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[ { "id": "NCT02748330_inc_text", "type": "inclusion", "text": [ "Provision of written informed consent (by patient or appropriate designee according to local regulations) prior to any study specific procedures.\nAged 18 years or older, male or female.\nHistory of stable angina pectoris with angiographic evidence of CAD (diameter stenosis = 50%) in major, i.e., left main, left anterior descending, left circumflex, and right coronary arteries.\nHistory of previous myocardial infarction (MI)\nHistory of coronary revascularization, i.e., percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG), not including the elective PCI during the index hospitalization\nDocumented history of type 2 diabetes mellitus.\nPost-procedural residual diameter stenosis of the treated lesions < 20% in patients with stent implantation or < 50% in those with balloon angioplasty\nPost-procedural thrombolysis in myocardial infarction (TIMI) grade 3 flow in treated vessels\nNegative cardiac troponin test before the index elective PCI.\nTaking Clopidogrel 75 mg daily dose for at least 7 days or taking Clopidogrel 75 mg daily dose for less than 7 days but with 300 to 600 mg Clopidogrel loading dose before PCI.\nTaking acetylsalicylic acid (ASA) 100 mg daily treatment for at least 7 days or taking ASA 100 mg daily dose for less than 7 days but with 300 mg ASA loading dose before PCI.\nhave a negative urine or blood pregnancy test at enrolment and prior to randomization;\ncurrently be using a hormonal contraceptive and agree to continue its use in addition to using double-barrier local contraception (i.e., intra-uterine device plus spermicidal and condom for male partner) from screening through study completion.\n" ], "offsets": [ [ 0, 1653 ] ] } ]

[ { "id": "NCT02748330_inc_T2", "type": "Person", "text": [ "Aged" ], "offsets": [ [ 146, 150 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T3", "type": "Value", "text": [ "18 years or older" ], "offsets": [ [ 151, 168 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T4", "type": "Person", "text": [ "male" ], "offsets": [ [ 170, 174 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T5", "type": "Person", "text": [ "female" ], "offsets": [ [ 178, 184 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T6", "type": "Condition", "text": [ "stable angina pectoris" ], "offsets": [ [ 197, 219 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T7", "type": "Qualifier", "text": [ "angiographic evidence" ], "offsets": [ [ 225, 246 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T8", "type": "Condition", "text": [ "CAD" ], "offsets": [ [ 250, 253 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T9", "type": "Observation", "text": [ "diameter stenosis" ], "offsets": [ [ 255, 272 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T10", "type": "Multiplier", "text": [ "= 50%" ], "offsets": [ [ 273, 278 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T11", "type": "Qualifier", "text": [ "right coronary arteries" ], "offsets": [ [ 354, 377 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T12", "type": "Qualifier", "text": [ "ft circumflex,", "ronary arteries." ], "offsets": [ [ 335, 349 ], [ 362, 378 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T13", "type": "Qualifier", "text": [ "ft anterior descending,", "ronary arteries." ], "offsets": [ [ 309, 332 ], [ 362, 378 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T14", "type": "Qualifier", "text": [ "ft main,", "ronary arteries." ], "offsets": [ [ 298, 306 ], [ 362, 378 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T16", "type": "Scope", "text": [ "left main, left anterior descending, left circumflex, and right coronary arteries" ], "offsets": [ [ 296, 377 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T17", "type": "Qualifier", "text": [ "jor,", "ronary arteries." ], "offsets": [ [ 285, 289 ], [ 362, 378 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T18", "type": "Condition", "text": [ "myocardial infarction" ], "offsets": [ [ 399, 420 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T19", "type": "Condition", "text": [ "MI" ], "offsets": [ [ 422, 424 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T20", "type": "Procedure", "text": [ "coronary revascularization" ], "offsets": [ [ 437, 463 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T21", "type": "Procedure", "text": [ "percutaneous coronary intervention" ], "offsets": [ [ 471, 505 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T22", "type": "Procedure", "text": [ "PCI" ], "offsets": [ [ 507, 510 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T23", "type": "Procedure", "text": [ "coronary artery bypass graft" ], "offsets": [ [ 515, 543 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T24", "type": "Procedure", "text": [ "CABG" ], "offsets": [ [ 545, 549 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T25", "type": "Negation", "text": [ "not" ], "offsets": [ [ 552, 555 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T26", "type": "Procedure", "text": [ "PCI" ], "offsets": [ [ 579, 582 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T27", "type": "Qualifier", "text": [ "elective" ], "offsets": [ [ 570, 578 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T28", "type": "Temporal", "text": [ "during the index hospitalization" ], "offsets": [ [ 583, 615 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T29", "type": "Reference_point", "text": [ "index hospitalization" ], "offsets": [ [ 594, 615 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T30", "type": "Scope", "text": [ "percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG), not including the elective PC" ], "offsets": [ [ 471, 581 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T31", "type": "Condition", "text": [ "type 2 diabetes mellitus" ], "offsets": [ [ 638, 662 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T32", "type": "Observation", "text": [ "Post-procedural residual diameter stenosis" ], "offsets": [ [ 664, 706 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T33", "type": "Condition", "text": [ "lesions" ], "offsets": [ [ 722, 729 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T34", "type": "Qualifier", "text": [ "treated" ], "offsets": [ [ 714, 721 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T35", "type": "Value", "text": [ "< 20%" ], "offsets": [ [ 730, 735 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T36", "type": "Procedure", "text": [ "stent implantation" ], "offsets": [ [ 753, 771 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T37", "type": "Procedure", "text": [ "balloon angioplasty" ], "offsets": [ [ 795, 814 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T38", "type": "Value", "text": [ "< 50%" ], "offsets": [ [ 775, 780 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T39", "type": "Condition", "text": [ "lesions" ], "offsets": [ [ 722, 729 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T40", "type": "Observation", "text": [ "Post-procedural residual diameter stenosis" ], "offsets": [ [ 664, 706 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T41", "type": "Condition", "text": [ "Post-procedural thrombolysis" ], "offsets": [ [ 815, 843 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T42", "type": "Condition", "text": [ "myocardial infarction" ], "offsets": [ [ 847, 868 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T43", "type": "Measurement", "text": [ "ial infarction (TIMI)", " flo" ], "offsets": [ [ 854, 875 ], [ 883, 887 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T44", "type": "Value", "text": [ "3" ], "offsets": [ [ 882, 883 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T45", "type": "Qualifier", "text": [ "treated vessels" ], "offsets": [ [ 892, 907 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T47", "type": "Measurement", "text": [ "cardiac troponin test" ], "offsets": [ [ 917, 938 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T48", "type": "Value", "text": [ "Negative" ], "offsets": [ [ 908, 916 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T49", "type": "Temporal", "text": [ "before the index elective PCI." ], "offsets": [ [ 939, 969 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T50", "type": "Reference_point", "text": [ "index elective PCI" ], "offsets": [ [ 950, 968 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T51", "type": "Procedure", "text": [ "PCI" ], "offsets": [ [ 965, 968 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T46", "type": "Measurement", "text": [ "TIMI" ], "offsets": [ [ 870, 874 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T52", "type": "Drug", "text": [ "Clopidogrel" ], "offsets": [ [ 977, 988 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T53", "type": "Multiplier", "text": [ "75 mg" ], "offsets": [ [ 989, 994 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T54", "type": "Multiplier", "text": [ "daily" ], "offsets": [ [ 995, 1000 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T55", "type": "Temporal", "text": [ "for at least 7 days" ], "offsets": [ [ 1006, 1025 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T56", "type": "Drug", "text": [ "Clopidogrel" ], "offsets": [ [ 1036, 1047 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T57", "type": "Multiplier", "text": [ "75 mg" ], "offsets": [ [ 1048, 1053 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T58", "type": "Multiplier", "text": [ "daily" ], "offsets": [ [ 1054, 1059 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T59", "type": "Temporal", "text": [ "for less than 7 days" ], "offsets": [ [ 1065, 1085 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T60", "type": "Drug", "text": [ "Clopidogrel" ], "offsets": [ [ 1109, 1120 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T61", "type": "Multiplier", "text": [ "300 to 600 mg" ], "offsets": [ [ 1095, 1108 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T62", "type": "Temporal", "text": [ "before PCI" ], "offsets": [ [ 1134, 1144 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T63", "type": "Reference_point", "text": [ "PCI" ], "offsets": [ [ 1141, 1144 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T64", "type": "Procedure", "text": [ "PCI" ], "offsets": [ [ 1141, 1144 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T65", "type": "Scope", "text": [ "Clopidogrel 75 mg daily dose for less than 7 days but with 300 to 600 mg Clopidogrel loading dose before PCI." ], "offsets": [ [ 1036, 1145 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T66", "type": "Drug", "text": [ "acetylsalicylic acid" ], "offsets": [ [ 1153, 1173 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T67", "type": "Drug", "text": [ "ASA" ], "offsets": [ [ 1175, 1178 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T68", "type": "Multiplier", "text": [ "100 mg" ], "offsets": [ [ 1180, 1186 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T69", "type": "Multiplier", "text": [ "daily" ], "offsets": [ [ 1187, 1192 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T70", "type": "Temporal", "text": [ "for at least 7 days" ], "offsets": [ [ 1203, 1222 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T71", "type": "Drug", "text": [ "ASA" ], "offsets": [ [ 1233, 1236 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T72", "type": "Multiplier", "text": [ "100 mg" ], "offsets": [ [ 1237, 1243 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T73", "type": "Multiplier", "text": [ "daily" ], "offsets": [ [ 1244, 1249 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T74", "type": "Temporal", "text": [ "for less than 7 days" ], "offsets": [ [ 1255, 1275 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T75", "type": "Drug", "text": [ "ASA" ], "offsets": [ [ 1292, 1295 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T76", "type": "Multiplier", "text": [ "300 mg" ], "offsets": [ [ 1285, 1291 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T77", "type": "Temporal", "text": [ "before PCI" ], "offsets": [ [ 1309, 1319 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T78", "type": "Reference_point", "text": [ "PCI" ], "offsets": [ [ 1316, 1319 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T79", "type": "Procedure", "text": [ "PCI" ], "offsets": [ [ 1316, 1319 ] ], "normalized": [] }, { "id": "NCT02748330_inc_T80", "type": "Scope", "text": [ "ASA 100 mg daily dose for less than 7 days but with 300 mg ASA loading dose before PCI" ], "offsets": [ [ 1233, 1319 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02748330_inc_R1", "type": "Has_value", "arg1_id": "NCT02748330_inc_T2", "arg2_id": "NCT02748330_inc_T3", "normalized": [] }, { "id": "NCT02748330_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02748330_inc_T8", "arg2_id": "NCT02748330_inc_T7", "normalized": [] }, { "id": "NCT02748330_inc_R3", "type": "Has_multiplier", "arg1_id": "NCT02748330_inc_T9", "arg2_id": "NCT02748330_inc_T10", "normalized": [] }, { "id": "NCT02748330_inc_R4", "type": "Subsumes", "arg1_id": "NCT02748330_inc_T17", "arg2_id": "NCT02748330_inc_T16", "normalized": [] }, { "id": "NCT02748330_inc_R6", "type": "Has_qualifier", "arg1_id": "NCT02748330_inc_T8", "arg2_id": "NCT02748330_inc_T17", "normalized": [] }, { "id": "NCT02748330_inc_R7", "type": "Subsumes", "arg1_id": "NCT02748330_inc_T18", "arg2_id": "NCT02748330_inc_T19", "normalized": [] }, { "id": "NCT02748330_inc_R8", "type": "Has_index", "arg1_id": "NCT02748330_inc_T28", "arg2_id": "NCT02748330_inc_T29", "normalized": [] }, { "id": "NCT02748330_inc_R9", "type": "Has_qualifier", "arg1_id": "NCT02748330_inc_T26", "arg2_id": "NCT02748330_inc_T27", "normalized": [] }, { "id": "NCT02748330_inc_R10", "type": "Has_negation", "arg1_id": "NCT02748330_inc_T26", "arg2_id": "NCT02748330_inc_T25", "normalized": [] }, { "id": "NCT02748330_inc_R11", "type": "Subsumes", "arg1_id": "NCT02748330_inc_T23", "arg2_id": "NCT02748330_inc_T24", "normalized": [] }, { "id": "NCT02748330_inc_R12", "type": "Subsumes", "arg1_id": "NCT02748330_inc_T21", "arg2_id": "NCT02748330_inc_T22", "normalized": [] }, { "id": "NCT02748330_inc_R13", "type": "Subsumes", "arg1_id": "NCT02748330_inc_T20", "arg2_id": "NCT02748330_inc_T30", "normalized": [] }, { "id": "NCT02748330_inc_R14", "type": "Has_temporal", "arg1_id": "NCT02748330_inc_T20", "arg2_id": "NCT02748330_inc_T28", "normalized": [] }, { "id": "NCT02748330_inc_R15", "type": "Has_qualifier", "arg1_id": "NCT02748330_inc_T33", "arg2_id": "NCT02748330_inc_T34", "normalized": [] }, { "id": "NCT02748330_inc_R17", "type": "Has_value", "arg1_id": "NCT02748330_inc_T32", "arg2_id": "NCT02748330_inc_T35", "normalized": [] }, { "id": "NCT02748330_inc_R18", "type": "AND", "arg1_id": "NCT02748330_inc_T33", "arg2_id": "NCT02748330_inc_T36", "normalized": [] }, { "id": "NCT02748330_inc_R19", "type": "Has_qualifier", "arg1_id": "NCT02748330_inc_T39", "arg2_id": "NCT02748330_inc_T34", "normalized": [] }, { "id": "NCT02748330_inc_R21", "type": "Has_value", "arg1_id": "NCT02748330_inc_T40", "arg2_id": "NCT02748330_inc_T38", "normalized": [] }, { "id": "NCT02748330_inc_R22", "type": "AND", "arg1_id": "NCT02748330_inc_T39", "arg2_id": "NCT02748330_inc_T37", "normalized": [] }, { "id": "NCT02748330_inc_R24", "type": "Has_value", "arg1_id": "NCT02748330_inc_T43", "arg2_id": "NCT02748330_inc_T44", "normalized": [] }, { "id": "NCT02748330_inc_R27", "type": "Has_index", "arg1_id": "NCT02748330_inc_T49", "arg2_id": "NCT02748330_inc_T50", "normalized": [] }, { "id": "NCT02748330_inc_R23", "type": "Subsumes", "arg1_id": "NCT02748330_inc_T43", "arg2_id": "NCT02748330_inc_T46", "normalized": [] }, { "id": "NCT02748330_inc_R26", "type": "Has_qualifier", "arg1_id": "NCT02748330_inc_T41", "arg2_id": "NCT02748330_inc_T45", "normalized": [] }, { "id": "NCT02748330_inc_R29", "type": "Has_temporal", "arg1_id": "NCT02748330_inc_T47", "arg2_id": "NCT02748330_inc_T49", "normalized": [] }, { "id": "NCT02748330_inc_R30", "type": "Has_value", "arg1_id": "NCT02748330_inc_T47", "arg2_id": "NCT02748330_inc_T48", "normalized": [] }, { "id": "NCT02748330_inc_R32", "type": "Has_index", "arg1_id": "NCT02748330_inc_T62", "arg2_id": "NCT02748330_inc_T63", "normalized": [] }, { "id": "NCT02748330_inc_R33", "type": "Has_multiplier", "arg1_id": "NCT02748330_inc_T60", "arg2_id": "NCT02748330_inc_T61", "normalized": [] }, { "id": "NCT02748330_inc_R34", "type": "Has_temporal", "arg1_id": "NCT02748330_inc_T60", "arg2_id": "NCT02748330_inc_T62", "normalized": [] }, { "id": "NCT02748330_inc_R35", "type": "Has_multiplier", "arg1_id": "NCT02748330_inc_T56", "arg2_id": "NCT02748330_inc_T57", "normalized": [] }, { "id": "NCT02748330_inc_R36", "type": "Has_multiplier", "arg1_id": "NCT02748330_inc_T56", "arg2_id": "NCT02748330_inc_T58", "normalized": [] }, { "id": "NCT02748330_inc_R37", "type": "Has_temporal", "arg1_id": "NCT02748330_inc_T56", "arg2_id": "NCT02748330_inc_T59", "normalized": [] }, { "id": "NCT02748330_inc_R38", "type": "Has_multiplier", "arg1_id": "NCT02748330_inc_T52", "arg2_id": "NCT02748330_inc_T53", "normalized": [] }, { "id": "NCT02748330_inc_R39", "type": "Has_multiplier", "arg1_id": "NCT02748330_inc_T52", "arg2_id": "NCT02748330_inc_T54", "normalized": [] }, { "id": "NCT02748330_inc_R40", "type": "Has_temporal", "arg1_id": "NCT02748330_inc_T52", "arg2_id": "NCT02748330_inc_T55", "normalized": [] }, { "id": "NCT02748330_inc_R41", "type": "Subsumes", "arg1_id": "NCT02748330_inc_T66", "arg2_id": "NCT02748330_inc_T67", "normalized": [] }, { "id": "NCT02748330_inc_R43", "type": "Has_index", "arg1_id": "NCT02748330_inc_T77", "arg2_id": "NCT02748330_inc_T78", "normalized": [] }, { "id": "NCT02748330_inc_R44", "type": "Has_multiplier", "arg1_id": "NCT02748330_inc_T75", "arg2_id": "NCT02748330_inc_T76", "normalized": [] }, { "id": "NCT02748330_inc_R45", "type": "Has_temporal", "arg1_id": "NCT02748330_inc_T75", "arg2_id": "NCT02748330_inc_T77", "normalized": [] }, { "id": "NCT02748330_inc_R46", "type": "Has_multiplier", "arg1_id": "NCT02748330_inc_T71", "arg2_id": "NCT02748330_inc_T72", "normalized": [] }, { "id": "NCT02748330_inc_R47", "type": "Has_multiplier", "arg1_id": "NCT02748330_inc_T71", "arg2_id": "NCT02748330_inc_T73", "normalized": [] }, { "id": "NCT02748330_inc_R48", "type": "Has_temporal", "arg1_id": "NCT02748330_inc_T71", "arg2_id": "NCT02748330_inc_T74", "normalized": [] }, { "id": "NCT02748330_inc_R49", "type": "Has_multiplier", "arg1_id": "NCT02748330_inc_T66", "arg2_id": "NCT02748330_inc_T68", "normalized": [] }, { "id": "NCT02748330_inc_R50", "type": "Has_multiplier", "arg1_id": "NCT02748330_inc_T66", "arg2_id": "NCT02748330_inc_T69", "normalized": [] }, { "id": "NCT02748330_inc_R51", "type": "Has_temporal", "arg1_id": "NCT02748330_inc_T66", "arg2_id": "NCT02748330_inc_T70", "normalized": [] } ]

[ { "id": "NCT02749617_exc_text", "type": "exclusion", "text": [ "Concomitant antiplatelet or anticoagulant use \nCalculated creatinine clearance < 30 mL/min by Cockcroft-Gault formula \nAlanine aminotransferase (ALT) or aspartate aminotransferase (AST) > 3 times upper limit of normal (ULN) \nTotal bilirubin > 2 x ULN \nThrombocytopenia < 50 x 10 gigalitres (Gl) \nHigh bleeding risk or spontaneously prolonged prothrombin time or activated partial thromboplastin time > 1.5 x ULN \nBody weight <50 or >120 kg \nConcomitant use of CYP3A4 or p-glycoprotein inducers or inhibitors \nUse of Ginkgo biloba or St. John's Wort within 14 days before first dose of study drug \nDexamethasone use within last 3 months \nWomen of Childbearing potential without proper contraceptive measures, pregnancy or breast feeding \nLife expectancy less than 3 months \nInability to swallow or issues with malabsorption \nAny other medical, social, logistical, geographical or psychological factors, which in the opinion of the investigator, would prohibit follow-up, compliance and study completion \n \n" ], "offsets": [ [ 0, 1014 ] ] } ]

[ { "id": "NCT02749617_exc_T1", "type": "Drug", "text": [ "antiplatelet" ], "offsets": [ [ 12, 24 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T2", "type": "Drug", "text": [ "anticoagulant" ], "offsets": [ [ 28, 41 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T3", "type": "Temporal", "text": [ "Concomitant" ], "offsets": [ [ 0, 11 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T4", "type": "Measurement", "text": [ "Calculated creatinine clearance" ], "offsets": [ [ 47, 78 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T5", "type": "Value", "text": [ "< 30 mL/min" ], "offsets": [ [ 79, 90 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T6", "type": "Measurement", "text": [ "Cockcroft-Gault formula" ], "offsets": [ [ 94, 117 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T7", "type": "Measurement", "text": [ "Alanine aminotransferase (ALT)" ], "offsets": [ [ 119, 149 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T8", "type": "Measurement", "text": [ "aspartate aminotransferase (AST)" ], "offsets": [ [ 153, 185 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T9", "type": "Value", "text": [ "> 3 times upper limit of normal (ULN)" ], "offsets": [ [ 186, 223 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T10", "type": "Measurement", "text": [ "Total bilirubin" ], "offsets": [ [ 225, 240 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T11", "type": "Value", "text": [ "> 2 x ULN" ], "offsets": [ [ 241, 250 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T12", "type": "Measurement", "text": [ "Thrombocytopenia" ], "offsets": [ [ 252, 268 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T13", "type": "Value", "text": [ "< 50 x 10 gigalitres (Gl)" ], "offsets": [ [ 269, 294 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T14", "type": "Condition", "text": [ "High bleeding risk" ], "offsets": [ [ 296, 314 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T15", "type": "Condition", "text": [ "prolonged prothrombin time" ], "offsets": [ [ 332, 358 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T16", "type": "Qualifier", "text": [ "spontaneously" ], "offsets": [ [ 318, 331 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T17", "type": "Measurement", "text": [ "activated partial thromboplastin time" ], "offsets": [ [ 362, 399 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T18", "type": "Value", "text": [ "> 1.5 x ULN" ], "offsets": [ [ 400, 411 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T19", "type": "Condition", "text": [ "Body weight" ], "offsets": [ [ 413, 424 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T20", "type": "Value", "text": [ "<50", "kg" ], "offsets": [ [ 425, 428 ], [ 437, 439 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T21", "type": "Value", "text": [ ">120 kg" ], "offsets": [ [ 432, 439 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T22", "type": "Scope", "text": [ "<50 or >120 kg" ], "offsets": [ [ 425, 439 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T23", "type": "Drug", "text": [ "CYP3A4" ], "offsets": [ [ 460, 466 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T24", "type": "Drug", "text": [ "p-glycoprotein inducers" ], "offsets": [ [ 470, 493 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T25", "type": "Drug", "text": [ "p-glycoprotein", "inhibitors" ], "offsets": [ [ 470, 484 ], [ 497, 507 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T26", "type": "Temporal", "text": [ "Concomitant" ], "offsets": [ [ 441, 452 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T27", "type": "Drug", "text": [ "Ginkgo biloba" ], "offsets": [ [ 516, 529 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T30", "type": "Drug", "text": [ "Dexamethasone" ], "offsets": [ [ 597, 610 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T31", "type": "Temporal", "text": [ "within last 3 months" ], "offsets": [ [ 615, 635 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T32", "type": "Person", "text": [ "Women" ], "offsets": [ [ 637, 642 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T33", "type": "Condition", "text": [ "Childbearing potential" ], "offsets": [ [ 646, 668 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T34", "type": "Procedure", "text": [ "contraceptive measures" ], "offsets": [ [ 684, 706 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T35", "type": "Negation", "text": [ "without" ], "offsets": [ [ 669, 676 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T36", "type": "Condition", "text": [ "pregnancy" ], "offsets": [ [ 708, 717 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T37", "type": "Observation", "text": [ "breast feeding" ], "offsets": [ [ 721, 735 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T38", "type": "Observation", "text": [ "Life expectancy" ], "offsets": [ [ 737, 752 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T39", "type": "Value", "text": [ "less than 3 months" ], "offsets": [ [ 753, 771 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T40", "type": "Condition", "text": [ "Inability to swallow" ], "offsets": [ [ 773, 793 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T41", "type": "Condition", "text": [ "issues with malabsorption" ], "offsets": [ [ 797, 822 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T28", "type": "Drug", "text": [ "St. John's Wort" ], "offsets": [ [ 533, 548 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T29", "type": "Temporal", "text": [ "within 14 days before first dose of study drug" ], "offsets": [ [ 549, 595 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T44", "type": "Reference_point", "text": [ "first dose of study drug" ], "offsets": [ [ 571, 595 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T46", "type": "Multiplier", "text": [ "first dose" ], "offsets": [ [ 571, 581 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T47", "type": "Drug", "text": [ "study drug" ], "offsets": [ [ 585, 595 ] ], "normalized": [] }, { "id": "NCT02749617_exc_T48", "type": "Scope", "text": [ "Ginkgo biloba or St. John's Wort" ], "offsets": [ [ 516, 548 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02749617_exc_R1", "type": "Has_temporal", "arg1_id": "NCT02749617_exc_T1", "arg2_id": "NCT02749617_exc_T3", "normalized": [] }, { "id": "NCT02749617_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02749617_exc_T2", "arg2_id": "NCT02749617_exc_T3", "normalized": [] }, { "id": "NCT02749617_exc_R3", "type": "AND", "arg1_id": "NCT02749617_exc_T4", "arg2_id": "NCT02749617_exc_T6", "normalized": [] }, { "id": "NCT02749617_exc_R4", "type": "Has_value", "arg1_id": "NCT02749617_exc_T4", "arg2_id": "NCT02749617_exc_T5", "normalized": [] }, { "id": "NCT02749617_exc_R5", "type": "Has_value", "arg1_id": "NCT02749617_exc_T8", "arg2_id": "NCT02749617_exc_T9", "normalized": [] }, { "id": "NCT02749617_exc_R6", "type": "Has_value", "arg1_id": "NCT02749617_exc_T7", "arg2_id": "NCT02749617_exc_T9", "normalized": [] }, { "id": "NCT02749617_exc_R7", "type": "Has_value", "arg1_id": "NCT02749617_exc_T10", "arg2_id": "NCT02749617_exc_T11", "normalized": [] }, { "id": "NCT02749617_exc_R8", "type": "Has_value", "arg1_id": "NCT02749617_exc_T12", "arg2_id": "NCT02749617_exc_T13", "normalized": [] }, { "id": "NCT02749617_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT02749617_exc_T15", "arg2_id": "NCT02749617_exc_T16", "normalized": [] }, { "id": "NCT02749617_exc_R10", "type": "Has_value", "arg1_id": "NCT02749617_exc_T17", "arg2_id": "NCT02749617_exc_T18", "normalized": [] }, { "id": "NCT02749617_exc_R11", "type": "Has_scope", "arg1_id": "NCT02749617_exc_T19", "arg2_id": "NCT02749617_exc_T22", "normalized": [] }, { "id": "NCT02749617_exc_R12", "type": "Has_temporal", "arg1_id": "NCT02749617_exc_T23", "arg2_id": "NCT02749617_exc_T26", "normalized": [] }, { "id": "NCT02749617_exc_R13", "type": "Has_temporal", "arg1_id": "NCT02749617_exc_T25", "arg2_id": "NCT02749617_exc_T26", "normalized": [] }, { "id": "NCT02749617_exc_R14", "type": "Has_temporal", "arg1_id": "NCT02749617_exc_T24", "arg2_id": "NCT02749617_exc_T26", "normalized": [] }, { "id": "NCT02749617_exc_R15", "type": "Has_temporal", "arg1_id": "NCT02749617_exc_T30", "arg2_id": "NCT02749617_exc_T31", "normalized": [] }, { "id": "NCT02749617_exc_R16", "type": "Has_negation", "arg1_id": "NCT02749617_exc_T34", "arg2_id": "NCT02749617_exc_T35", "normalized": [] }, { "id": "NCT02749617_exc_R17", "type": "AND", "arg1_id": "NCT02749617_exc_T33", "arg2_id": "NCT02749617_exc_T34", "normalized": [] }, { "id": "NCT02749617_exc_R18", "type": "Has_value", "arg1_id": "NCT02749617_exc_T38", "arg2_id": "NCT02749617_exc_T39", "normalized": [] }, { "id": "NCT02749617_exc_R19", "type": "Has_multiplier", "arg1_id": "NCT02749617_exc_T47", "arg2_id": "NCT02749617_exc_T46", "normalized": [] }, { "id": "NCT02749617_exc_R21", "type": "Has_index", "arg1_id": "NCT02749617_exc_T29", "arg2_id": "NCT02749617_exc_T44", "normalized": [] }, { "id": "NCT02749617_exc_R22", "type": "Has_temporal", "arg1_id": "NCT02749617_exc_T48", "arg2_id": "NCT02749617_exc_T29", "normalized": [] } ]

[ { "id": "NCT02749617_inc_text", "type": "inclusion", "text": [ "Patients with diagnosis of multiple myeloma according to criteria of the International Myeloma Working Group \nPatients in whom a LEN-DEX-based treatment regimen is indicated \nAdult patients ≥ 19 years of age who are able to freely provide informed consent \n" ], "offsets": [ [ 0, 257 ] ] } ]

[ { "id": "NCT02749617_inc_T1", "type": "Condition", "text": [ "multiple myeloma" ], "offsets": [ [ 27, 43 ] ], "normalized": [] }, { "id": "NCT02749617_inc_T2", "type": "Measurement", "text": [ "criteria of the International Myeloma Working Group" ], "offsets": [ [ 57, 108 ] ], "normalized": [] }, { "id": "NCT02749617_inc_T6", "type": "Drug", "text": [ "DEX" ], "offsets": [ [ 133, 136 ] ], "normalized": [] }, { "id": "NCT02749617_inc_T7", "type": "Drug", "text": [ "LEN" ], "offsets": [ [ 129, 132 ] ], "normalized": [] }, { "id": "NCT02749617_inc_T8", "type": "Qualifier", "text": [ "LEN-DEX-based" ], "offsets": [ [ 129, 142 ] ], "normalized": [] }, { "id": "NCT02749617_inc_T9", "type": "Procedure", "text": [ "treatment regimen" ], "offsets": [ [ 143, 160 ] ], "normalized": [] }, { "id": "NCT02749617_inc_T10", "type": "Mood", "text": [ "is indicated" ], "offsets": [ [ 161, 173 ] ], "normalized": [] }, { "id": "NCT02749617_inc_T11", "type": "Person", "text": [ "Adult" ], "offsets": [ [ 175, 180 ] ], "normalized": [] }, { "id": "NCT02749617_inc_T12", "type": "Value", "text": [ "≥ 19 years" ], "offsets": [ [ 190, 200 ] ], "normalized": [] }, { "id": "NCT02749617_inc_T13", "type": "Person", "text": [ "age" ], "offsets": [ [ 204, 207 ] ], "normalized": [] }, { "id": "NCT02749617_inc_T14", "type": "Observation", "text": [ "able to freely provide informed consent" ], "offsets": [ [ 216, 255 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02749617_inc_R1", "type": "AND", "arg1_id": "NCT02749617_inc_T1", "arg2_id": "NCT02749617_inc_T2", "normalized": [] }, { "id": "NCT02749617_inc_R2", "type": "AND", "arg1_id": "NCT02749617_inc_T8", "arg2_id": "NCT02749617_inc_T7", "normalized": [] }, { "id": "NCT02749617_inc_R3", "type": "AND", "arg1_id": "NCT02749617_inc_T8", "arg2_id": "NCT02749617_inc_T6", "normalized": [] }, { "id": "NCT02749617_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT02749617_inc_T9", "arg2_id": "NCT02749617_inc_T8", "normalized": [] }, { "id": "NCT02749617_inc_R5", "type": "Has_mood", "arg1_id": "NCT02749617_inc_T9", "arg2_id": "NCT02749617_inc_T10", "normalized": [] }, { "id": "NCT02749617_inc_R6", "type": "Has_value", "arg1_id": "NCT02749617_inc_T13", "arg2_id": "NCT02749617_inc_T12", "normalized": [] } ]

[ { "id": "NCT02754583_exc_text", "type": "exclusion", "text": [ "School districts that are too difficult to reach (more than a 3-hour walk from the farthest place reachable by a four-wheel drive vehicle)\nSchool districts in the 2 urban regions of the study area\nRefusal of village chief\nAll residents residing near to the well sites that are randomly selected for this study.\nRefusal of participant [or parent/guardian]\n" ], "offsets": [ [ 0, 355 ] ] } ]

[ { "id": "NCT02754583_exc_T1", "type": "Visit", "text": [ "School districts that are too difficult to reach" ], "offsets": [ [ 0, 48 ] ], "normalized": [] }, { "id": "NCT02754583_exc_T2", "type": "Measurement", "text": [ "walk from the farthest place reachable by a four-wheel drive vehicle" ], "offsets": [ [ 69, 137 ] ], "normalized": [] }, { "id": "NCT02754583_exc_T3", "type": "Value", "text": [ "more than a 3-hour" ], "offsets": [ [ 50, 68 ] ], "normalized": [] }, { "id": "NCT02754583_exc_T4", "type": "Visit", "text": [ "School districts in the 2 urban regions of the study area" ], "offsets": [ [ 139, 196 ] ], "normalized": [] }, { "id": "NCT02754583_exc_T6", "type": "Observation", "text": [ "residing" ], "offsets": [ [ 236, 244 ] ], "normalized": [] }, { "id": "NCT02754583_exc_T7", "type": "Visit", "text": [ "near to the well sites" ], "offsets": [ [ 245, 267 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02754583_exc_R1", "type": "Has_value", "arg1_id": "NCT02754583_exc_T2", "arg2_id": "NCT02754583_exc_T3", "normalized": [] }, { "id": "NCT02754583_exc_R2", "type": "AND", "arg1_id": "NCT02754583_exc_T6", "arg2_id": "NCT02754583_exc_T7", "normalized": [] } ]

[ { "id": "NCT02754583_inc_text", "type": "inclusion", "text": [ "Community in a school district that is within the study area\nArea within each school district that is in need of a well\n" ], "offsets": [ [ 0, 120 ] ] } ]

[ { "id": "NCT02754583_inc_T1", "type": "Visit", "text": [ "school district that is within the study area" ], "offsets": [ [ 15, 60 ] ], "normalized": [] }, { "id": "NCT02754583_inc_T2", "type": "Visit", "text": [ "school district that is in need of a well" ], "offsets": [ [ 78, 119 ] ], "normalized": [] } ]

[]

[]

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[ { "id": "NCT02755701_exc_text", "type": "exclusion", "text": [ "Child-Pugh score > 12\nHaving been diagnosed as HCC within the past 5 years\nSerum creatinine > 1.5mg/dl\nSerum bilirubin > 5.0mg/dl\nPresence of such complications as SBP, or hepatic encephalopathy(West Haven grade = 3)\nPatients who experienced organ failure by acute exacerbation of liver cirrhosis within the past 1 month\nPresence of serious cardiac or respiratory disease\nContraindicated to either diuretics or BCAA\nHaving commenced anti-viral treatment against hepatitis C, B within the past 1 month\nPregnant or lactating women\nChronic alcohol taker\nWoman patients who do not agree to the contraception from baseline to 12 month\nUnsuitable patients judged by investigator\nPatients participating in another clinical trial within 1 month\n" ], "offsets": [ [ 0, 737 ] ] } ]

[ { "id": "NCT02755701_exc_T1", "type": "Measurement", "text": [ "Child-Pugh score" ], "offsets": [ [ 0, 16 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T2", "type": "Value", "text": [ "> 12" ], "offsets": [ [ 17, 21 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T3", "type": "Condition", "text": [ "HCC" ], "offsets": [ [ 47, 50 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T4", "type": "Temporal", "text": [ "past 5 years" ], "offsets": [ [ 62, 74 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T5", "type": "Measurement", "text": [ "Serum creatinine" ], "offsets": [ [ 75, 91 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T6", "type": "Value", "text": [ "> 1.5mg/dl" ], "offsets": [ [ 92, 102 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T7", "type": "Measurement", "text": [ "Serum bilirubin" ], "offsets": [ [ 103, 118 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T8", "type": "Value", "text": [ "> 5.0mg/d" ], "offsets": [ [ 119, 128 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T9", "type": "Condition", "text": [ "complications" ], "offsets": [ [ 147, 160 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T10", "type": "Condition", "text": [ "SBP" ], "offsets": [ [ 164, 167 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T11", "type": "Condition", "text": [ "hepatic encephalopathy" ], "offsets": [ [ 172, 194 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T12", "type": "Measurement", "text": [ "West Haven grade" ], "offsets": [ [ 195, 211 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T13", "type": "Value", "text": [ "= 3" ], "offsets": [ [ 212, 215 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T14", "type": "Scope", "text": [ "SBP, or hepatic encephalopathy(West Haven grade = 3)" ], "offsets": [ [ 164, 216 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T15", "type": "Condition", "text": [ "organ failure" ], "offsets": [ [ 242, 255 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T16", "type": "Condition", "text": [ "acute exacerbation of liver cirrhosis" ], "offsets": [ [ 259, 296 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T17", "type": "Temporal", "text": [ "past 1 month" ], "offsets": [ [ 308, 320 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T18", "type": "Condition", "text": [ "respiratory disease" ], "offsets": [ [ 352, 371 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T19", "type": "Condition", "text": [ "c or re", "e\nContr" ], "offsets": [ [ 347, 354 ], [ 370, 377 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T20", "type": "Scope", "text": [ "cardiac or respiratory disease" ], "offsets": [ [ 341, 371 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T21", "type": "Qualifier", "text": [ "serious" ], "offsets": [ [ 333, 340 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T22", "type": "Condition", "text": [ "Contraindicated" ], "offsets": [ [ 372, 387 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T23", "type": "Drug", "text": [ "diuretics" ], "offsets": [ [ 398, 407 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T24", "type": "Drug", "text": [ "BCAA" ], "offsets": [ [ 411, 415 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T25", "type": "Scope", "text": [ "diuretics or BCAA" ], "offsets": [ [ 398, 415 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T26", "type": "Procedure", "text": [ "anti-viral treatment" ], "offsets": [ [ 433, 453 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T27", "type": "Condition", "text": [ "hepatitis C" ], "offsets": [ [ 462, 473 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T28", "type": "Condition", "text": [ "s C, B wi", "" ], "offsets": [ [ 470, 479 ], [ 483, 483 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T29", "type": "Scope", "text": [ "hepatitis C, B" ], "offsets": [ [ 462, 476 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T30", "type": "Temporal", "text": [ "past 1 month" ], "offsets": [ [ 488, 500 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T32", "type": "Qualifier", "text": [ "Chronic" ], "offsets": [ [ 529, 536 ] ], "normalized": [] }, { "id": "NCT02755701_exc_T33", "type": "Person", "text": [ "alcohol taker" ], "offsets": [ [ 537, 550 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02755701_exc_R1", "type": "Has_value", "arg1_id": "NCT02755701_exc_T1", "arg2_id": "NCT02755701_exc_T2", "normalized": [] }, { "id": "NCT02755701_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02755701_exc_T3", "arg2_id": "NCT02755701_exc_T4", "normalized": [] }, { "id": "NCT02755701_exc_R3", "type": "Has_value", "arg1_id": "NCT02755701_exc_T5", "arg2_id": "NCT02755701_exc_T6", "normalized": [] }, { "id": "NCT02755701_exc_R4", "type": "Has_value", "arg1_id": "NCT02755701_exc_T7", "arg2_id": "NCT02755701_exc_T8", "normalized": [] }, { "id": "NCT02755701_exc_R5", "type": "Has_value", "arg1_id": "NCT02755701_exc_T12", "arg2_id": "NCT02755701_exc_T13", "normalized": [] }, { "id": "NCT02755701_exc_R6", "type": "AND", "arg1_id": "NCT02755701_exc_T11", "arg2_id": "NCT02755701_exc_T12", "normalized": [] }, { "id": "NCT02755701_exc_R7", "type": "Subsumes", "arg1_id": "NCT02755701_exc_T9", "arg2_id": "NCT02755701_exc_T14", "normalized": [] }, { "id": "NCT02755701_exc_R8", "type": "AND", "arg1_id": "NCT02755701_exc_T15", "arg2_id": "NCT02755701_exc_T16", "normalized": [] }, { "id": "NCT02755701_exc_R9", "type": "Has_temporal", "arg1_id": "NCT02755701_exc_T16", "arg2_id": "NCT02755701_exc_T17", "normalized": [] }, { "id": "NCT02755701_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT02755701_exc_T20", "arg2_id": "NCT02755701_exc_T21", "normalized": [] }, { "id": "NCT02755701_exc_R11", "type": "Has_scope", "arg1_id": "NCT02755701_exc_T22", "arg2_id": "NCT02755701_exc_T25", "normalized": [] }, { "id": "NCT02755701_exc_R12", "type": "Has_scope", "arg1_id": "NCT02755701_exc_T26", "arg2_id": "NCT02755701_exc_T29", "normalized": [] }, { "id": "NCT02755701_exc_R13", "type": "Has_temporal", "arg1_id": "NCT02755701_exc_T26", "arg2_id": "NCT02755701_exc_T30", "normalized": [] }, { "id": "NCT02755701_exc_R14", "type": "Has_qualifier", "arg1_id": "NCT02755701_exc_T33", "arg2_id": "NCT02755701_exc_T32", "normalized": [] } ]

[ { "id": "NCT02755701_inc_text", "type": "inclusion", "text": [ "Age = 19 and = 70 years;\nPresence of liver cirrhosis\nSerum albumin level = 3.5g/dl, ultrasound or CT scan confirmed ascites (=Grade 1)\nNo administration of diuretics and BCAA within the past 1 week\nVoluntary consent to take part in this trial\n" ], "offsets": [ [ 0, 243 ] ] } ]

[ { "id": "NCT02755701_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02755701_inc_T2", "type": "Value", "text": [ "= 19 and = 70 years" ], "offsets": [ [ 4, 23 ] ], "normalized": [] }, { "id": "NCT02755701_inc_T3", "type": "Condition", "text": [ "liver cirrhosis" ], "offsets": [ [ 37, 52 ] ], "normalized": [] }, { "id": "NCT02755701_inc_T4", "type": "Measurement", "text": [ "Serum albumin" ], "offsets": [ [ 53, 66 ] ], "normalized": [] }, { "id": "NCT02755701_inc_T5", "type": "Value", "text": [ "= 3.5g/dl" ], "offsets": [ [ 73, 82 ] ], "normalized": [] }, { "id": "NCT02755701_inc_T6", "type": "Procedure", "text": [ "ultrasound" ], "offsets": [ [ 84, 94 ] ], "normalized": [] }, { "id": "NCT02755701_inc_T7", "type": "Procedure", "text": [ "CT scan" ], "offsets": [ [ 98, 105 ] ], "normalized": [] }, { "id": "NCT02755701_inc_T8", "type": "Condition", "text": [ "ascites" ], "offsets": [ [ 116, 123 ] ], "normalized": [] }, { "id": "NCT02755701_inc_T9", "type": "Qualifier", "text": [ "Grade 1" ], "offsets": [ [ 126, 133 ] ], "normalized": [] }, { "id": "NCT02755701_inc_T10", "type": "Scope", "text": [ "ultrasound or CT scan" ], "offsets": [ [ 84, 105 ] ], "normalized": [] }, { "id": "NCT02755701_inc_T11", "type": "Negation", "text": [ "No" ], "offsets": [ [ 135, 137 ] ], "normalized": [] }, { "id": "NCT02755701_inc_T12", "type": "Drug", "text": [ "diuretics" ], "offsets": [ [ 156, 165 ] ], "normalized": [] }, { "id": "NCT02755701_inc_T13", "type": "Drug", "text": [ "BCAA" ], "offsets": [ [ 170, 174 ] ], "normalized": [] }, { "id": "NCT02755701_inc_T14", "type": "Scope", "text": [ "diuretics and BCAA" ], "offsets": [ [ 156, 174 ] ], "normalized": [] }, { "id": "NCT02755701_inc_T15", "type": "Temporal", "text": [ "past 1 week" ], "offsets": [ [ 186, 197 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02755701_inc_R1", "type": "Has_value", "arg1_id": "NCT02755701_inc_T1", "arg2_id": "NCT02755701_inc_T2", "normalized": [] }, { "id": "NCT02755701_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02755701_inc_T8", "arg2_id": "NCT02755701_inc_T9", "normalized": [] }, { "id": "NCT02755701_inc_R3", "type": "AND", "arg1_id": "NCT02755701_inc_T10", "arg2_id": "NCT02755701_inc_T8", "normalized": [] }, { "id": "NCT02755701_inc_R4", "type": "Has_value", "arg1_id": "NCT02755701_inc_T4", "arg2_id": "NCT02755701_inc_T5", "normalized": [] }, { "id": "NCT02755701_inc_R5", "type": "Has_negation", "arg1_id": "NCT02755701_inc_T14", "arg2_id": "NCT02755701_inc_T11", "normalized": [] }, { "id": "NCT02755701_inc_R6", "type": "Has_temporal", "arg1_id": "NCT02755701_inc_T14", "arg2_id": "NCT02755701_inc_T15", "normalized": [] } ]

[ { "id": "NCT02759861_exc_text", "type": "exclusion", "text": [ "Pregnant women and nursing mothers are ineligible due to the possible risk of adverse effects in the newborn. Eligible patients of reproductive potential should use adequate contraception if sexually active.\nSerious concurrent medical illness which would jeopardize the ability of the subject to receive the therapy as outlined in this protocol with reasonable safety.\nMalignancy diagnosed or treated within 5 years (recent localized treatment of squamous or non-invasive basal cell skin cancers is permitted; cervical carcinoma in situ is allowed if appropriately treated prior to screening); subjects under evaluation for a malignancy are not eligible.\nInfection with hepatitis B virus (HBV) or human immunodeficiency virus (HIV)\nUse of any prohibited concomitant medications within 30 days of the Baseline/Day 1 visit.\nKnown hypersensitivity to LDV/SOF\n" ], "offsets": [ [ 0, 856 ] ] } ]

[ { "id": "NCT02759861_exc_T3", "type": "Condition", "text": [ "Malignancy" ], "offsets": [ [ 369, 379 ] ], "normalized": [] }, { "id": "NCT02759861_exc_T4", "type": "Temporal", "text": [ "within 5 years" ], "offsets": [ [ 401, 415 ] ], "normalized": [] }, { "id": "NCT02759861_exc_T5", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 434, 443 ] ], "normalized": [] }, { "id": "NCT02759861_exc_T6", "type": "Qualifier", "text": [ "localized" ], "offsets": [ [ 424, 433 ] ], "normalized": [] }, { "id": "NCT02759861_exc_T7", "type": "Temporal", "text": [ "recent" ], "offsets": [ [ 417, 423 ] ], "normalized": [] }, { "id": "NCT02759861_exc_T8", "type": "Condition", "text": [ "uamous o", "ll skin cancers" ], "offsets": [ [ 449, 457 ], [ 480, 495 ] ], "normalized": [] }, { "id": "NCT02759861_exc_T9", "type": "Condition", "text": [ "non-invasive basal cell skin cancer" ], "offsets": [ [ 459, 494 ] ], "normalized": [] }, { "id": "NCT02759861_exc_T10", "type": "Negation", "text": [ "permitted" ], "offsets": [ [ 499, 508 ] ], "normalized": [] }, { "id": "NCT02759861_exc_T11", "type": "Scope", "text": [ "squamous or non-invasive basal cell skin cancer" ], "offsets": [ [ 447, 494 ] ], "normalized": [] }, { "id": "NCT02759861_exc_T12", "type": "Condition", "text": [ "cervical carcinoma in situ" ], "offsets": [ [ 510, 536 ] ], "normalized": [] }, { "id": "NCT02759861_exc_T13", "type": "Negation", "text": [ "allowed" ], "offsets": [ [ 540, 547 ] ], "normalized": [] }, { "id": "NCT02759861_exc_T14", "type": "Procedure", "text": [ "treated" ], "offsets": [ [ 565, 572 ] ], "normalized": [] }, { "id": "NCT02759861_exc_T15", "type": "Qualifier", "text": [ "appropriately" ], "offsets": [ [ 551, 564 ] ], "normalized": [] }, { "id": "NCT02759861_exc_T16", "type": "Temporal", "text": [ "prior to screening" ], "offsets": [ [ 573, 591 ] ], "normalized": [] }, { "id": "NCT02759861_exc_T18", "type": "Condition", "text": [ "hepatitis B virus (HBV)" ], "offsets": [ [ 670, 693 ] ], "normalized": [] }, { "id": "NCT02759861_exc_T19", "type": "Condition", "text": [ "human immunodeficiency virus (HIV)" ], "offsets": [ [ 697, 731 ] ], "normalized": [] }, { "id": "NCT02759861_exc_T21", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 828, 844 ] ], "normalized": [] }, { "id": "NCT02759861_exc_T22", "type": "Drug", "text": [ "LDV" ], "offsets": [ [ 848, 851 ] ], "normalized": [] }, { "id": "NCT02759861_exc_T23", "type": "Drug", "text": [ "SOF" ], "offsets": [ [ 852, 855 ] ], "normalized": [] }, { "id": "NCT02759861_exc_T24", "type": "Scope", "text": [ "LDV/SOF" ], "offsets": [ [ 848, 855 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02759861_exc_R1", "type": "Has_temporal", "arg1_id": "NCT02759861_exc_T3", "arg2_id": "NCT02759861_exc_T4", "normalized": [] }, { "id": "NCT02759861_exc_R2", "type": "Has_scope", "arg1_id": "NCT02759861_exc_T5", "arg2_id": "NCT02759861_exc_T11", "normalized": [] }, { "id": "NCT02759861_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02759861_exc_T5", "arg2_id": "NCT02759861_exc_T6", "normalized": [] }, { "id": "NCT02759861_exc_R4", "type": "Has_negation", "arg1_id": "NCT02759861_exc_T5", "arg2_id": "NCT02759861_exc_T10", "normalized": [] }, { "id": "NCT02759861_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02759861_exc_T14", "arg2_id": "NCT02759861_exc_T15", "normalized": [] }, { "id": "NCT02759861_exc_R6", "type": "Has_temporal", "arg1_id": "NCT02759861_exc_T14", "arg2_id": "NCT02759861_exc_T16", "normalized": [] }, { "id": "NCT02759861_exc_R7", "type": "AND", "arg1_id": "NCT02759861_exc_T12", "arg2_id": "NCT02759861_exc_T14", "normalized": [] }, { "id": "NCT02759861_exc_R8", "type": "Has_negation", "arg1_id": "NCT02759861_exc_T12", "arg2_id": "NCT02759861_exc_T13", "normalized": [] }, { "id": "NCT02759861_exc_R9", "type": "Has_scope", "arg1_id": "NCT02759861_exc_T21", "arg2_id": "NCT02759861_exc_T24", "normalized": [] } ]

[ { "id": "NCT02759861_inc_text", "type": "inclusion", "text": [ "The subject must be willingly and able to provide written informed consent\nAge 19 years of age or older (The age of consent in Nebraska)\nHCV treatment-naïve, as defined as no prior exposure to any Interferon (IFN), RBV, or other FDA approved or experimental HCV-specific direct-acting antiviral agent\nHCV RNA level at most 6 months prior to the Baseline/Day 1 visit.\nHCV genotyping 1a, 1b, or mixed 1a/ab. Any non-definitive results will exclude the subject from study participation.\nAlcohol misuse as defined by the Alcohol Use Disorders Identification Test (AUDIT) score subjects must score > 8 (associated with harmful or hazardous drinking)\nHistory of a liver biopsy showing cirrhosis (e.g. Metavir score = 4 or Ishak score > 5)\nFibroscan showing cirrhosis or results > 12.5 kPa\nFIBRO Spect II index consistent with F3 or F4 AND an AST : platelet ration index (APRI) of > 2 during Screening\nLiver biopsy within 2 years of Screening showing absence of cirrhosis\nFibroscan within 6 months of Baseline/Day1 with a result of = 12.5 kPa\nFIBRO Spect II Index consistent with F0- F2 AND APRI of = 1 during Screening\nLiver imaging within 6 months of Baseline/Day 1 to exclude hepatocellular carcinoma HCC) is required\nALT < 10 x the upper limit of normal (ULN)\nAST < 10 x ULN\nDirect bilirubin < 2.0 x ULN\nPlatelets > 50,000\nHbA1c < 8.5%\nCreatinine clearance (CLcr) = 60 mL /min, as calculated by the Cockcroft-Gault equation\nHemoglobin = 11 g/dL for female subjects; = 12 g/dL for male subjects.\nAlbumin = 2.5 g/dL\nINR = 1.5 x ULN unless subject has known hemophilia or is stable on an anticoagulant regimen affecting INR.\nSubject has not been treated with any investigational drug or device within 30 days of the screening visit.\n" ], "offsets": [ [ 0, 1727 ] ] } ]

[ { "id": "NCT02759861_inc_T2", "type": "Value", "text": [ "19 years of age or older" ], "offsets": [ [ 79, 103 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T3", "type": "Person", "text": [ "Age" ], "offsets": [ [ 75, 78 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T5", "type": "Negation", "text": [ "naïve" ], "offsets": [ [ 151, 156 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T6", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 141, 150 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T7", "type": "Condition", "text": [ "HCV" ], "offsets": [ [ 137, 140 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T9", "type": "Drug", "text": [ "Interferon (IFN)" ], "offsets": [ [ 197, 213 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T8", "type": "Drug", "text": [ "RBV" ], "offsets": [ [ 215, 218 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T11", "type": "Negation", "text": [ "no" ], "offsets": [ [ 172, 174 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T12", "type": "Temporal", "text": [ "prior" ], "offsets": [ [ 175, 180 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T13", "type": "Scope", "text": [ "Interferon (IFN), RBV" ], "offsets": [ [ 197, 218 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T14", "type": "Scope", "text": [ "HCV treatment-naïve" ], "offsets": [ [ 137, 156 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T15", "type": "Scope", "text": [ "no prior exposure to any Interferon (IFN), RBV, or other FDA approved or experimental HCV-specific direct-acting antiviral agent" ], "offsets": [ [ 172, 300 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T16", "type": "Measurement", "text": [ "HCV RNA level" ], "offsets": [ [ 301, 314 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T17", "type": "Temporal", "text": [ "at most 6 months prior to the Baseline/Day 1 visit" ], "offsets": [ [ 315, 365 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T18", "type": "Reference_point", "text": [ "the Baseline/Day 1 visit" ], "offsets": [ [ 341, 365 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T19", "type": "Measurement", "text": [ "HCV genotyping" ], "offsets": [ [ 367, 381 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T20", "type": "Value", "text": [ "1a, 1b, or mixed 1a/ab" ], "offsets": [ [ 382, 404 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T22", "type": "Condition", "text": [ "Alcohol misuse" ], "offsets": [ [ 484, 498 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T23", "type": "Measurement", "text": [ "Alcohol Use Disorders Identification Test (AUDIT) score" ], "offsets": [ [ 517, 572 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T24", "type": "Value", "text": [ "> 8" ], "offsets": [ [ 593, 596 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T25", "type": "Procedure", "text": [ "liver biopsy" ], "offsets": [ [ 658, 670 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T26", "type": "Condition", "text": [ "cirrhosis" ], "offsets": [ [ 679, 688 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T27", "type": "Measurement", "text": [ "Metavir score" ], "offsets": [ [ 695, 708 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T28", "type": "Measurement", "text": [ "Ishak score" ], "offsets": [ [ 716, 727 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T29", "type": "Value", "text": [ "= 4" ], "offsets": [ [ 709, 712 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T30", "type": "Value", "text": [ "> 5" ], "offsets": [ [ 728, 731 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T31", "type": "Scope", "text": [ "Metavir score = 4 or Ishak score > 5" ], "offsets": [ [ 695, 731 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T32", "type": "Procedure", "text": [ "Fibroscan" ], "offsets": [ [ 733, 742 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T33", "type": "Condition", "text": [ "cirrhosis" ], "offsets": [ [ 751, 760 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T34", "type": "Value", "text": [ "> 12.5 kPa" ], "offsets": [ [ 772, 782 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T35", "type": "Scope", "text": [ "cirrhosis or results > 12.5 kPa" ], "offsets": [ [ 751, 782 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T36", "type": "Measurement", "text": [ "FIBRO Spect II index" ], "offsets": [ [ 783, 803 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T37", "type": "Measurement", "text": [ "platelet ration index (APRI)" ], "offsets": [ [ 842, 870 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T38", "type": "Value", "text": [ "> 2" ], "offsets": [ [ 874, 877 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T39", "type": "Temporal", "text": [ "during Screening" ], "offsets": [ [ 878, 894 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T40", "type": "Value", "text": [ "F3 or F4" ], "offsets": [ [ 820, 828 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T41", "type": "Value", "text": [ "AST" ], "offsets": [ [ 836, 839 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T42", "type": "Procedure", "text": [ "Liver biopsy" ], "offsets": [ [ 895, 907 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T43", "type": "Temporal", "text": [ "within 2 years of Screening" ], "offsets": [ [ 908, 935 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T44", "type": "Condition", "text": [ "cirrhosis" ], "offsets": [ [ 955, 964 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T45", "type": "Negation", "text": [ "absence" ], "offsets": [ [ 944, 951 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T46", "type": "Procedure", "text": [ "Fibroscan" ], "offsets": [ [ 965, 974 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T47", "type": "Temporal", "text": [ "within 6 months of Baseline/Day1" ], "offsets": [ [ 975, 1007 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T48", "type": "Value", "text": [ "= 12.5 kPa" ], "offsets": [ [ 1025, 1035 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T49", "type": "Measurement", "text": [ "FIBRO Spect II Index" ], "offsets": [ [ 1036, 1056 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T50", "type": "Value", "text": [ "F0- F2" ], "offsets": [ [ 1073, 1079 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T51", "type": "Measurement", "text": [ "APRI" ], "offsets": [ [ 1084, 1088 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T52", "type": "Value", "text": [ "= 1" ], "offsets": [ [ 1092, 1095 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T53", "type": "Temporal", "text": [ "during Screening" ], "offsets": [ [ 1096, 1112 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T54", "type": "Procedure", "text": [ "Liver imaging" ], "offsets": [ [ 1113, 1126 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T55", "type": "Temporal", "text": [ "within 6 months of Baseline/Day 1" ], "offsets": [ [ 1127, 1160 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T56", "type": "Condition", "text": [ "hepatocellular carcinoma HCC)" ], "offsets": [ [ 1172, 1201 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T57", "type": "Negation", "text": [ "exclude" ], "offsets": [ [ 1164, 1171 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T58", "type": "Measurement", "text": [ "ALT" ], "offsets": [ [ 1214, 1217 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T59", "type": "Measurement", "text": [ "AST" ], "offsets": [ [ 1257, 1260 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T60", "type": "Value", "text": [ "< 10 x the upper limit of normal (ULN)" ], "offsets": [ [ 1218, 1256 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T61", "type": "Value", "text": [ "< 10 x ULN" ], "offsets": [ [ 1261, 1271 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T62", "type": "Measurement", "text": [ "Direct bilirubin" ], "offsets": [ [ 1272, 1288 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T63", "type": "Value", "text": [ "< 2.0 x ULN" ], "offsets": [ [ 1289, 1300 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T64", "type": "Measurement", "text": [ "Platelets" ], "offsets": [ [ 1301, 1310 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T65", "type": "Value", "text": [ "> 50,000" ], "offsets": [ [ 1311, 1319 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T66", "type": "Measurement", "text": [ "HbA1c" ], "offsets": [ [ 1320, 1325 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T67", "type": "Value", "text": [ "< 8.5%" ], "offsets": [ [ 1326, 1332 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T68", "type": "Measurement", "text": [ "Creatinine clearance (CLcr)" ], "offsets": [ [ 1333, 1360 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T69", "type": "Value", "text": [ "= 60 mL /min" ], "offsets": [ [ 1361, 1373 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T70", "type": "Qualifier", "text": [ "Cockcroft-Gault equation" ], "offsets": [ [ 1396, 1420 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T71", "type": "Measurement", "text": [ "Hemoglobin" ], "offsets": [ [ 1421, 1431 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T72", "type": "Value", "text": [ "= 11 g/dL" ], "offsets": [ [ 1432, 1441 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T73", "type": "Person", "text": [ "female" ], "offsets": [ [ 1446, 1452 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T74", "type": "Value", "text": [ "= 12 g/dL" ], "offsets": [ [ 1463, 1472 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T75", "type": "Person", "text": [ "male" ], "offsets": [ [ 1477, 1481 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T76", "type": "Scope", "text": [ "= 11 g/dL for female subjects; = 12 g/dL for male" ], "offsets": [ [ 1432, 1481 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T77", "type": "Measurement", "text": [ "Albumin" ], "offsets": [ [ 1492, 1499 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T78", "type": "Value", "text": [ "= 2.5 g/dL" ], "offsets": [ [ 1500, 1510 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T79", "type": "Measurement", "text": [ "INR" ], "offsets": [ [ 1511, 1514 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T80", "type": "Value", "text": [ "= 1.5 x ULN" ], "offsets": [ [ 1515, 1526 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T81", "type": "Condition", "text": [ "hemophilia" ], "offsets": [ [ 1552, 1562 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T82", "type": "Condition", "text": [ "stable on an anticoagulant regimen affecting INR" ], "offsets": [ [ 1569, 1617 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T83", "type": "Negation", "text": [ "unless" ], "offsets": [ [ 1527, 1533 ] ], "normalized": [] }, { "id": "NCT02759861_inc_T84", "type": "Scope", "text": [ "hemophilia or is stable on an anticoagulant regimen affecting INR" ], "offsets": [ [ 1552, 1617 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02759861_inc_R1", "type": "Has_value", "arg1_id": "NCT02759861_inc_T3", "arg2_id": "NCT02759861_inc_T2", "normalized": [] }, { "id": "NCT02759861_inc_R2", "type": "Has_negation", "arg1_id": "NCT02759861_inc_T6", "arg2_id": "NCT02759861_inc_T5", "normalized": [] }, { "id": "NCT02759861_inc_R3", "type": "AND", "arg1_id": "NCT02759861_inc_T6", "arg2_id": "NCT02759861_inc_T7", "normalized": [] }, { "id": "NCT02759861_inc_R4", "type": "Has_temporal", "arg1_id": "NCT02759861_inc_T13", "arg2_id": "NCT02759861_inc_T12", "normalized": [] }, { "id": "NCT02759861_inc_R5", "type": "Has_negation", "arg1_id": "NCT02759861_inc_T13", "arg2_id": "NCT02759861_inc_T11", "normalized": [] }, { "id": "NCT02759861_inc_R6", "type": "Subsumes", "arg1_id": "NCT02759861_inc_T14", "arg2_id": "NCT02759861_inc_T15", "normalized": [] }, { "id": "NCT02759861_inc_R7", "type": "Has_temporal", "arg1_id": "NCT02759861_inc_T16", "arg2_id": "NCT02759861_inc_T17", "normalized": [] }, { "id": "NCT02759861_inc_R8", "type": "Has_index", "arg1_id": "NCT02759861_inc_T17", "arg2_id": "NCT02759861_inc_T18", "normalized": [] }, { "id": "NCT02759861_inc_R9", "type": "Has_value", "arg1_id": "NCT02759861_inc_T19", "arg2_id": "NCT02759861_inc_T20", "normalized": [] }, { "id": "NCT02759861_inc_R10", "type": "Has_value", "arg1_id": "NCT02759861_inc_T23", "arg2_id": "NCT02759861_inc_T24", "normalized": [] }, { "id": "NCT02759861_inc_R11", "type": "Subsumes", "arg1_id": "NCT02759861_inc_T22", "arg2_id": "NCT02759861_inc_T23", "normalized": [] }, { "id": "NCT02759861_inc_R12", "type": "Has_value", "arg1_id": "NCT02759861_inc_T27", "arg2_id": "NCT02759861_inc_T29", "normalized": [] }, { "id": "NCT02759861_inc_R13", "type": "Has_value", "arg1_id": "NCT02759861_inc_T28", "arg2_id": "NCT02759861_inc_T30", "normalized": [] }, { "id": "NCT02759861_inc_R14", "type": "Subsumes", "arg1_id": "NCT02759861_inc_T26", "arg2_id": "NCT02759861_inc_T31", "normalized": [] }, { "id": "NCT02759861_inc_R15", "type": "AND", "arg1_id": "NCT02759861_inc_T25", "arg2_id": "NCT02759861_inc_T26", "normalized": [] }, { "id": "NCT02759861_inc_R16", "type": "Has_scope", "arg1_id": "NCT02759861_inc_T32", "arg2_id": "NCT02759861_inc_T35", "normalized": [] }, { "id": "NCT02759861_inc_R17", "type": "Has_value", "arg1_id": "NCT02759861_inc_T37", "arg2_id": "NCT02759861_inc_T38", "normalized": [] }, { "id": "NCT02759861_inc_R18", "type": "Has_value", "arg1_id": "NCT02759861_inc_T36", "arg2_id": "NCT02759861_inc_T40", "normalized": [] }, { "id": "NCT02759861_inc_R19", "type": "Has_value", "arg1_id": "NCT02759861_inc_T36", "arg2_id": "NCT02759861_inc_T41", "normalized": [] }, { "id": "NCT02759861_inc_R20", "type": "Has_negation", "arg1_id": "NCT02759861_inc_T44", "arg2_id": "NCT02759861_inc_T45", "normalized": [] }, { "id": "NCT02759861_inc_R21", "type": "Has_temporal", "arg1_id": "NCT02759861_inc_T42", "arg2_id": "NCT02759861_inc_T43", "normalized": [] }, { "id": "NCT02759861_inc_R22", "type": "AND", "arg1_id": "NCT02759861_inc_T42", "arg2_id": "NCT02759861_inc_T44", "normalized": [] }, { "id": "NCT02759861_inc_R23", "type": "Has_value", "arg1_id": "NCT02759861_inc_T46", "arg2_id": "NCT02759861_inc_T48", "normalized": [] }, { "id": "NCT02759861_inc_R24", "type": "Has_temporal", "arg1_id": "NCT02759861_inc_T46", "arg2_id": "NCT02759861_inc_T47", "normalized": [] }, { "id": "NCT02759861_inc_R25", "type": "Has_value", "arg1_id": "NCT02759861_inc_T51", "arg2_id": "NCT02759861_inc_T52", "normalized": [] }, { "id": "NCT02759861_inc_R27", "type": "AND", "arg1_id": "NCT02759861_inc_T36", "arg2_id": "NCT02759861_inc_T37", "normalized": [] }, { "id": "NCT02759861_inc_R28", "type": "Has_value", "arg1_id": "NCT02759861_inc_T49", "arg2_id": "NCT02759861_inc_T50", "normalized": [] }, { "id": "NCT02759861_inc_R29", "type": "AND", "arg1_id": "NCT02759861_inc_T49", "arg2_id": "NCT02759861_inc_T51", "normalized": [] }, { "id": "NCT02759861_inc_R30", "type": "Has_temporal", "arg1_id": "NCT02759861_inc_T49", "arg2_id": "NCT02759861_inc_T53", "normalized": [] }, { "id": "NCT02759861_inc_R26", "type": "Has_temporal", "arg1_id": "NCT02759861_inc_T36", "arg2_id": "NCT02759861_inc_T39", "normalized": [] }, { "id": "NCT02759861_inc_R31", "type": "Has_temporal", "arg1_id": "NCT02759861_inc_T54", "arg2_id": "NCT02759861_inc_T55", "normalized": [] }, { "id": "NCT02759861_inc_R32", "type": "Has_negation", "arg1_id": "NCT02759861_inc_T56", "arg2_id": "NCT02759861_inc_T57", "normalized": [] }, { "id": "NCT02759861_inc_R33", "type": "AND", "arg1_id": "NCT02759861_inc_T54", "arg2_id": "NCT02759861_inc_T56", "normalized": [] }, { "id": "NCT02759861_inc_R34", "type": "Has_value", "arg1_id": "NCT02759861_inc_T58", "arg2_id": "NCT02759861_inc_T60", "normalized": [] }, { "id": "NCT02759861_inc_R35", "type": "Has_value", "arg1_id": "NCT02759861_inc_T59", "arg2_id": "NCT02759861_inc_T61", "normalized": [] }, { "id": "NCT02759861_inc_R36", "type": "Has_value", "arg1_id": "NCT02759861_inc_T64", "arg2_id": "NCT02759861_inc_T65", "normalized": [] }, { "id": "NCT02759861_inc_R37", "type": "Has_value", "arg1_id": "NCT02759861_inc_T62", "arg2_id": "NCT02759861_inc_T63", "normalized": [] }, { "id": "NCT02759861_inc_R38", "type": "Has_value", "arg1_id": "NCT02759861_inc_T66", "arg2_id": "NCT02759861_inc_T67", "normalized": [] }, { "id": "NCT02759861_inc_R39", "type": "Has_value", "arg1_id": "NCT02759861_inc_T68", "arg2_id": "NCT02759861_inc_T69", "normalized": [] }, { "id": "NCT02759861_inc_R40", "type": "Has_qualifier", "arg1_id": "NCT02759861_inc_T68", "arg2_id": "NCT02759861_inc_T70", "normalized": [] }, { "id": "NCT02759861_inc_R41", "type": "Has_value", "arg1_id": "NCT02759861_inc_T75", "arg2_id": "NCT02759861_inc_T74", "normalized": [] }, { "id": "NCT02759861_inc_R42", "type": "Has_value", "arg1_id": "NCT02759861_inc_T73", "arg2_id": "NCT02759861_inc_T72", "normalized": [] }, { "id": "NCT02759861_inc_R43", "type": "Has_scope", "arg1_id": "NCT02759861_inc_T71", "arg2_id": "NCT02759861_inc_T76", "normalized": [] }, { "id": "NCT02759861_inc_R44", "type": "Has_value", "arg1_id": "NCT02759861_inc_T77", "arg2_id": "NCT02759861_inc_T78", "normalized": [] }, { "id": "NCT02759861_inc_R45", "type": "Has_value", "arg1_id": "NCT02759861_inc_T79", "arg2_id": "NCT02759861_inc_T80", "normalized": [] }, { "id": "NCT02759861_inc_R46", "type": "Has_negation", "arg1_id": "NCT02759861_inc_T84", "arg2_id": "NCT02759861_inc_T83", "normalized": [] }, { "id": "NCT02759861_inc_R47", "type": "Has_scope", "arg1_id": "NCT02759861_inc_T79", "arg2_id": "NCT02759861_inc_T84", "normalized": [] } ]

[ { "id": "NCT02760251_exc_text", "type": "exclusion", "text": [ "Adults older than 45 and children younger than 18 years\nPlatelet count higher than 30x109/l at time of screening\nSuspicion of secondary ITP\nPositive family history for ITP\nPresence or history of autoimmune disease as judged by the investigator\nHepatosplenomegaly\nPresence or history of relevant hepatic disease as judged by the investigator\nPresence or history of thromboembolic disease as judged by the investigator\nPatients with splenectomy\nWomen who are pregnant or breast feeding\nIntention to become pregnant during the course of the study\nLack of safe double contraception (see 7.1)\nAny vaccination 2 weeks prior start of the study\nDrugs with a known impact on the immune system or on platelet function must be recorded and an exclusion of the study should be discussed with the study center\nKnown or suspected non-compliance, drug or alcohol abuse\nInability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia of the study subject\nParticipation in another study with investigational drug within the 30 days preceding and during the present study\nPrevious enrolment into the current study\nPrevious treatment with romiplostim or eltrombopag\nHypersensitivity to the active substance or to any of the excipients or to E. coli derived proteins\nEnrolment of the investigator, his/her family members, employees and other dependent persons\n" ], "offsets": [ [ 0, 1390 ] ] } ]

[ { "id": "NCT02760251_exc_T1", "type": "Person", "text": [ "Adults" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T2", "type": "Value", "text": [ "older than 45" ], "offsets": [ [ 7, 20 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T3", "type": "Person", "text": [ "children" ], "offsets": [ [ 25, 33 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T4", "type": "Value", "text": [ "younger than 18 years" ], "offsets": [ [ 34, 55 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T5", "type": "Measurement", "text": [ "Platelet count" ], "offsets": [ [ 56, 70 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T6", "type": "Value", "text": [ "higher than 30x109/l" ], "offsets": [ [ 71, 91 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T7", "type": "Temporal", "text": [ "at time of screening" ], "offsets": [ [ 92, 112 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T8", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 103, 112 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T9", "type": "Condition", "text": [ "secondary ITP" ], "offsets": [ [ 126, 139 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T10", "type": "Observation", "text": [ "family history for ITP" ], "offsets": [ [ 149, 171 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T12", "type": "Condition", "text": [ "autoimmune disease" ], "offsets": [ [ 195, 213 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T17", "type": "Condition", "text": [ "hepatic disease" ], "offsets": [ [ 295, 310 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T18", "type": "Qualifier", "text": [ "relevant" ], "offsets": [ [ 286, 294 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T21", "type": "Condition", "text": [ "thromboembolic disease" ], "offsets": [ [ 364, 386 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T22", "type": "Procedure", "text": [ "splenectomy" ], "offsets": [ [ 431, 442 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T26", "type": "Procedure", "text": [ "vaccination" ], "offsets": [ [ 592, 603 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T27", "type": "Temporal", "text": [ "2 weeks prior start of the study" ], "offsets": [ [ 604, 636 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T28", "type": "Reference_point", "text": [ "start of the study" ], "offsets": [ [ 618, 636 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T30", "type": "Condition", "text": [ "alcohol abuse" ], "offsets": [ [ 840, 853 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T31", "type": "Condition", "text": [ "l ab", "y to" ], "offsets": [ [ 846, 850 ], [ 862, 866 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T32", "type": "Qualifier", "text": [ "non-compliance" ], "offsets": [ [ 816, 830 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T33", "type": "Scope", "text": [ "drug or alcohol abuse" ], "offsets": [ [ 832, 853 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T37", "type": "Drug", "text": [ "romiplostim" ], "offsets": [ [ 1170, 1181 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T38", "type": "Drug", "text": [ "eltrombopag" ], "offsets": [ [ 1185, 1196 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T39", "type": "Condition", "text": [ "Hypersensitivity" ], "offsets": [ [ 1197, 1213 ] ], "normalized": [] }, { "id": "NCT02760251_exc_T42", "type": "Condition", "text": [ "Hepatosplenomegaly" ], "offsets": [ [ 244, 262 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02760251_exc_R1", "type": "Has_value", "arg1_id": "NCT02760251_exc_T3", "arg2_id": "NCT02760251_exc_T4", "normalized": [] }, { "id": "NCT02760251_exc_R2", "type": "Has_value", "arg1_id": "NCT02760251_exc_T1", "arg2_id": "NCT02760251_exc_T2", "normalized": [] }, { "id": "NCT02760251_exc_R3", "type": "Has_index", "arg1_id": "NCT02760251_exc_T7", "arg2_id": "NCT02760251_exc_T8", "normalized": [] }, { "id": "NCT02760251_exc_R4", "type": "Has_value", "arg1_id": "NCT02760251_exc_T5", "arg2_id": "NCT02760251_exc_T6", "normalized": [] }, { "id": "NCT02760251_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02760251_exc_T5", "arg2_id": "NCT02760251_exc_T7", "normalized": [] }, { "id": "NCT02760251_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02760251_exc_T17", "arg2_id": "NCT02760251_exc_T18", "normalized": [] }, { "id": "NCT02760251_exc_R7", "type": "Has_index", "arg1_id": "NCT02760251_exc_T27", "arg2_id": "NCT02760251_exc_T28", "normalized": [] }, { "id": "NCT02760251_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02760251_exc_T26", "arg2_id": "NCT02760251_exc_T27", "normalized": [] }, { "id": "NCT02760251_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT02760251_exc_T33", "arg2_id": "NCT02760251_exc_T32", "normalized": [] } ]

[ { "id": "NCT02760251_inc_text", "type": "inclusion", "text": [ "Informed consent as documented by signature (see informed consent form)\nPrimary ITP according to the definition of Rodeghiero et al. (52) and a platelet count of <30x109/l\nAge range: 18-45 years\nPreviously treated patients, with failure or intolerance to first-line therapy, or relapse after first-line therapy, i.e. corticosteroids, intravenous immunoglobulin (IVIG), or anti-D immunoglobulins\n" ], "offsets": [ [ 0, 395 ] ] } ]

[ { "id": "NCT02760251_inc_T2", "type": "Condition", "text": [ "Primary ITP" ], "offsets": [ [ 72, 83 ] ], "normalized": [] }, { "id": "NCT02760251_inc_T3", "type": "Measurement", "text": [ "definition of Rodeghiero" ], "offsets": [ [ 101, 125 ] ], "normalized": [] }, { "id": "NCT02760251_inc_T4", "type": "Measurement", "text": [ "platelet count" ], "offsets": [ [ 144, 158 ] ], "normalized": [] }, { "id": "NCT02760251_inc_T5", "type": "Value", "text": [ "<30x109/l" ], "offsets": [ [ 162, 171 ] ], "normalized": [] }, { "id": "NCT02760251_inc_T6", "type": "Scope", "text": [ "definition of Rodeghiero et al. (52) and a platelet count of <30x109/l" ], "offsets": [ [ 101, 171 ] ], "normalized": [] }, { "id": "NCT02760251_inc_T7", "type": "Person", "text": [ "Age" ], "offsets": [ [ 172, 175 ] ], "normalized": [] }, { "id": "NCT02760251_inc_T8", "type": "Value", "text": [ "18-45 years" ], "offsets": [ [ 183, 194 ] ], "normalized": [] }, { "id": "NCT02760251_inc_T9", "type": "Observation", "text": [ "Previously treated" ], "offsets": [ [ 195, 213 ] ], "normalized": [] }, { "id": "NCT02760251_inc_T10", "type": "Procedure", "text": [ "first-line therapy" ], "offsets": [ [ 255, 273 ] ], "normalized": [] }, { "id": "NCT02760251_inc_T11", "type": "Qualifier", "text": [ "failure" ], "offsets": [ [ 229, 236 ] ], "normalized": [] }, { "id": "NCT02760251_inc_T12", "type": "Qualifier", "text": [ "intolerance" ], "offsets": [ [ 240, 251 ] ], "normalized": [] }, { "id": "NCT02760251_inc_T13", "type": "Condition", "text": [ "relapse" ], "offsets": [ [ 278, 285 ] ], "normalized": [] }, { "id": "NCT02760251_inc_T14", "type": "Temporal", "text": [ "after first-line therapy" ], "offsets": [ [ 286, 310 ] ], "normalized": [] }, { "id": "NCT02760251_inc_T15", "type": "Reference_point", "text": [ "first-line therapy" ], "offsets": [ [ 292, 310 ] ], "normalized": [] }, { "id": "NCT02760251_inc_T16", "type": "Procedure", "text": [ "first-line therapy" ], "offsets": [ [ 292, 310 ] ], "normalized": [] }, { "id": "NCT02760251_inc_T17", "type": "Drug", "text": [ "corticosteroids" ], "offsets": [ [ 317, 332 ] ], "normalized": [] }, { "id": "NCT02760251_inc_T18", "type": "Drug", "text": [ "intravenous immunoglobulin" ], "offsets": [ [ 334, 360 ] ], "normalized": [] }, { "id": "NCT02760251_inc_T19", "type": "Drug", "text": [ "anti-D immunoglobulins" ], "offsets": [ [ 372, 394 ] ], "normalized": [] }, { "id": "NCT02760251_inc_T20", "type": "Drug", "text": [ "IVIG" ], "offsets": [ [ 362, 366 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02760251_inc_R1", "type": "Has_value", "arg1_id": "NCT02760251_inc_T4", "arg2_id": "NCT02760251_inc_T5", "normalized": [] }, { "id": "NCT02760251_inc_R2", "type": "AND", "arg1_id": "NCT02760251_inc_T6", "arg2_id": "NCT02760251_inc_T2", "normalized": [] }, { "id": "NCT02760251_inc_R3", "type": "Has_value", "arg1_id": "NCT02760251_inc_T7", "arg2_id": "NCT02760251_inc_T8", "normalized": [] }, { "id": "NCT02760251_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT02760251_inc_T10", "arg2_id": "NCT02760251_inc_T12", "normalized": [] }, { "id": "NCT02760251_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT02760251_inc_T10", "arg2_id": "NCT02760251_inc_T11", "normalized": [] }, { "id": "NCT02760251_inc_R7", "type": "Has_index", "arg1_id": "NCT02760251_inc_T14", "arg2_id": "NCT02760251_inc_T15", "normalized": [] }, { "id": "NCT02760251_inc_R8", "type": "Has_temporal", "arg1_id": "NCT02760251_inc_T13", "arg2_id": "NCT02760251_inc_T14", "normalized": [] }, { "id": "NCT02760251_inc_R9", "type": "Subsumes", "arg1_id": "NCT02760251_inc_T18", "arg2_id": "NCT02760251_inc_T20", "normalized": [] } ]

[ { "id": "NCT02760459_exc_text", "type": "exclusion", "text": [ "History of active rheumatic diseases\nHistory of previous musculoskeletal injury of the same knee for excluding patients with secondary knee osteoarthritis\nHistory of previous surgery on the same knee\nHistory of adverse effects from medications to be used in this study\nContraindication to spinal anesthesia\nHistory of psychiatric disorders or cognitive impairment\nContraindication to corticosteroid agents\nPoorly controlled diabetes mellitus (HbA1C > 7.5)\nPoorly controlled hypertension\nHistory of ischemic heart disease or peripheral arterial disease or cerebrovascular disease\nHepatic insufficiency (Child-Pugh score > 5)\nRenal insufficiency (Creatinine clearance < 30 mL/min)\nHistory of cataracts or glaucoma or ocular hypertension\nHistory of steroid or immunosuppressive drug use within 6 months of surgery\n" ], "offsets": [ [ 0, 811 ] ] } ]

[ { "id": "NCT02760459_exc_T1", "type": "Condition", "text": [ "rheumatic diseases" ], "offsets": [ [ 18, 36 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T2", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 11, 17 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T3", "type": "Condition", "text": [ "musculoskeletal injury" ], "offsets": [ [ 57, 79 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T4", "type": "Qualifier", "text": [ "knee" ], "offsets": [ [ 92, 96 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T5", "type": "Condition", "text": [ "secondary knee osteoarthritis" ], "offsets": [ [ 125, 154 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T6", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 175, 182 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T7", "type": "Qualifier", "text": [ "knee" ], "offsets": [ [ 195, 199 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T9", "type": "Condition", "text": [ "Contraindication" ], "offsets": [ [ 269, 285 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T10", "type": "Procedure", "text": [ "spinal anesthesia" ], "offsets": [ [ 289, 306 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T11", "type": "Condition", "text": [ "psychiatric disorders" ], "offsets": [ [ 318, 339 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T12", "type": "Condition", "text": [ "cognitive impairment" ], "offsets": [ [ 343, 363 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T13", "type": "Condition", "text": [ "Contraindication" ], "offsets": [ [ 364, 380 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T14", "type": "Drug", "text": [ "corticosteroid" ], "offsets": [ [ 384, 398 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T15", "type": "Condition", "text": [ "diabetes mellitus" ], "offsets": [ [ 424, 441 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T16", "type": "Qualifier", "text": [ "Poorly controlled" ], "offsets": [ [ 406, 423 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T17", "type": "Measurement", "text": [ "HbA1C" ], "offsets": [ [ 443, 448 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T18", "type": "Value", "text": [ "> 7.5" ], "offsets": [ [ 449, 454 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T19", "type": "Qualifier", "text": [ "Poorly controlled" ], "offsets": [ [ 456, 473 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T20", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 474, 486 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T21", "type": "Condition", "text": [ "ischemic heart disease" ], "offsets": [ [ 498, 520 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T22", "type": "Condition", "text": [ "peripheral arterial disease" ], "offsets": [ [ 524, 551 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T23", "type": "Condition", "text": [ "cerebrovascular disease" ], "offsets": [ [ 555, 578 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T24", "type": "Condition", "text": [ "Hepatic insufficiency" ], "offsets": [ [ 579, 600 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T25", "type": "Measurement", "text": [ "Child-Pugh score" ], "offsets": [ [ 602, 618 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T26", "type": "Value", "text": [ "> 5" ], "offsets": [ [ 619, 622 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T27", "type": "Condition", "text": [ "Renal insufficiency" ], "offsets": [ [ 624, 643 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T28", "type": "Measurement", "text": [ "Creatinine clearance" ], "offsets": [ [ 645, 665 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T29", "type": "Value", "text": [ "< 30 mL/min" ], "offsets": [ [ 666, 677 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T30", "type": "Condition", "text": [ "cataracts" ], "offsets": [ [ 690, 699 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T31", "type": "Condition", "text": [ "glaucoma" ], "offsets": [ [ 703, 711 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T32", "type": "Condition", "text": [ "ocular hypertension" ], "offsets": [ [ 715, 734 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T33", "type": "Drug", "text": [ "steroid" ], "offsets": [ [ 746, 753 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T34", "type": "Drug", "text": [ "immunosuppressive drug" ], "offsets": [ [ 757, 779 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T35", "type": "Temporal", "text": [ "within 6 months of surgery" ], "offsets": [ [ 784, 810 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T36", "type": "Reference_point", "text": [ "surgery" ], "offsets": [ [ 803, 810 ] ], "normalized": [] }, { "id": "NCT02760459_exc_T37", "type": "Scope", "text": [ "steroid or immunosuppressive drug" ], "offsets": [ [ 746, 779 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02760459_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02760459_exc_T1", "arg2_id": "NCT02760459_exc_T2", "normalized": [] }, { "id": "NCT02760459_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02760459_exc_T3", "arg2_id": "NCT02760459_exc_T4", "normalized": [] }, { "id": "NCT02760459_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02760459_exc_T6", "arg2_id": "NCT02760459_exc_T7", "normalized": [] }, { "id": "NCT02760459_exc_R4", "type": "AND", "arg1_id": "NCT02760459_exc_T9", "arg2_id": "NCT02760459_exc_T10", "normalized": [] }, { "id": "NCT02760459_exc_R5", "type": "AND", "arg1_id": "NCT02760459_exc_T13", "arg2_id": "NCT02760459_exc_T14", "normalized": [] }, { "id": "NCT02760459_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02760459_exc_T15", "arg2_id": "NCT02760459_exc_T16", "normalized": [] }, { "id": "NCT02760459_exc_R7", "type": "Has_value", "arg1_id": "NCT02760459_exc_T17", "arg2_id": "NCT02760459_exc_T18", "normalized": [] }, { "id": "NCT02760459_exc_R8", "type": "AND", "arg1_id": "NCT02760459_exc_T15", "arg2_id": "NCT02760459_exc_T17", "normalized": [] }, { "id": "NCT02760459_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT02760459_exc_T20", "arg2_id": "NCT02760459_exc_T19", "normalized": [] }, { "id": "NCT02760459_exc_R10", "type": "Has_value", "arg1_id": "NCT02760459_exc_T25", "arg2_id": "NCT02760459_exc_T26", "normalized": [] }, { "id": "NCT02760459_exc_R11", "type": "AND", "arg1_id": "NCT02760459_exc_T24", "arg2_id": "NCT02760459_exc_T25", "normalized": [] }, { "id": "NCT02760459_exc_R12", "type": "AND", "arg1_id": "NCT02760459_exc_T27", "arg2_id": "NCT02760459_exc_T28", "normalized": [] }, { "id": "NCT02760459_exc_R13", "type": "Has_value", "arg1_id": "NCT02760459_exc_T28", "arg2_id": "NCT02760459_exc_T29", "normalized": [] }, { "id": "NCT02760459_exc_R14", "type": "Has_index", "arg1_id": "NCT02760459_exc_T35", "arg2_id": "NCT02760459_exc_T36", "normalized": [] }, { "id": "NCT02760459_exc_R15", "type": "Has_temporal", "arg1_id": "NCT02760459_exc_T37", "arg2_id": "NCT02760459_exc_T35", "normalized": [] } ]

[ { "id": "NCT02760459_inc_text", "type": "inclusion", "text": [ "Age > 40 years (45)\nPrimary knee osteoarthritis diagnosed using the American College of Rheumatology criteria (46)\nUndergoing elective, primary and unilateral total knee arthroplasty\nAmerican Society of Anesthesiology (ASA) physical status class 1-3\nBMI < 40 kg/m2\n" ], "offsets": [ [ 0, 265 ] ] } ]

[ { "id": "NCT02760459_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02760459_inc_T2", "type": "Value", "text": [ "> 40 years" ], "offsets": [ [ 4, 14 ] ], "normalized": [] }, { "id": "NCT02760459_inc_T3", "type": "Condition", "text": [ "Primary knee osteoarthritis" ], "offsets": [ [ 20, 47 ] ], "normalized": [] }, { "id": "NCT02760459_inc_T4", "type": "Qualifier", "text": [ "American College of Rheumatology criteria" ], "offsets": [ [ 68, 109 ] ], "normalized": [] }, { "id": "NCT02760459_inc_T5", "type": "Procedure", "text": [ "total knee arthroplasty" ], "offsets": [ [ 159, 182 ] ], "normalized": [] }, { "id": "NCT02760459_inc_T6", "type": "Qualifier", "text": [ "unilateral" ], "offsets": [ [ 148, 158 ] ], "normalized": [] }, { "id": "NCT02760459_inc_T7", "type": "Qualifier", "text": [ "primary" ], "offsets": [ [ 136, 143 ] ], "normalized": [] }, { "id": "NCT02760459_inc_T8", "type": "Qualifier", "text": [ "elective" ], "offsets": [ [ 126, 134 ] ], "normalized": [] }, { "id": "NCT02760459_inc_T9", "type": "Measurement", "text": [ "rican Society of Anesthesiology (A", "sical status class 1-" ], "offsets": [ [ 186, 220 ], [ 227, 248 ] ], "normalized": [] }, { "id": "NCT02760459_inc_T10", "type": "Value", "text": [ "1-3" ], "offsets": [ [ 246, 249 ] ], "normalized": [] }, { "id": "NCT02760459_inc_T11", "type": "Measurement", "text": [ "ASA" ], "offsets": [ [ 219, 222 ] ], "normalized": [] }, { "id": "NCT02760459_inc_T12", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 250, 253 ] ], "normalized": [] }, { "id": "NCT02760459_inc_T13", "type": "Value", "text": [ "< 40 kg/m2" ], "offsets": [ [ 254, 264 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02760459_inc_R1", "type": "Has_value", "arg1_id": "NCT02760459_inc_T1", "arg2_id": "NCT02760459_inc_T2", "normalized": [] }, { "id": "NCT02760459_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02760459_inc_T3", "arg2_id": "NCT02760459_inc_T4", "normalized": [] }, { "id": "NCT02760459_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT02760459_inc_T5", "arg2_id": "NCT02760459_inc_T6", "normalized": [] }, { "id": "NCT02760459_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT02760459_inc_T5", "arg2_id": "NCT02760459_inc_T7", "normalized": [] }, { "id": "NCT02760459_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT02760459_inc_T5", "arg2_id": "NCT02760459_inc_T8", "normalized": [] }, { "id": "NCT02760459_inc_R6", "type": "Subsumes", "arg1_id": "NCT02760459_inc_T9", "arg2_id": "NCT02760459_inc_T11", "normalized": [] }, { "id": "NCT02760459_inc_R7", "type": "Has_value", "arg1_id": "NCT02760459_inc_T9", "arg2_id": "NCT02760459_inc_T10", "normalized": [] }, { "id": "NCT02760459_inc_R8", "type": "Has_value", "arg1_id": "NCT02760459_inc_T12", "arg2_id": "NCT02760459_inc_T13", "normalized": [] } ]

[ { "id": "NCT02762851_exc_text", "type": "exclusion", "text": [ "Anaphylactic reaction to a previous dose of TIV(trivalent influenza vaccine)\nKnown IgE( Immunoglobulin E)-mediated hypersensitivity to eggs manifested as hives, swelling of the mouth and throat, difficulty in breathing, hypotension, or shock\nGuillain-Barré syndrome within eight weeks of a previous influenza vaccine\nAnaphylactic reaction to neomycin\nPatients who have had influenza vaccine in two of the three previous years\n" ], "offsets": [ [ 0, 426 ] ] } ]

[ { "id": "NCT02762851_exc_T1", "type": "Condition", "text": [ "Anaphylactic reaction" ], "offsets": [ [ 0, 21 ] ], "normalized": [] }, { "id": "NCT02762851_exc_T2", "type": "Drug", "text": [ "trivalent influenza vaccine" ], "offsets": [ [ 48, 75 ] ], "normalized": [] }, { "id": "NCT02762851_exc_T3", "type": "Drug", "text": [ "TIV" ], "offsets": [ [ 44, 47 ] ], "normalized": [] }, { "id": "NCT02762851_exc_T4", "type": "Condition", "text": [ "IgE( Immunoglobulin E)-mediated hypersensitivity" ], "offsets": [ [ 83, 131 ] ], "normalized": [] }, { "id": "NCT02762851_exc_T5", "type": "Drug", "text": [ "eggs" ], "offsets": [ [ 135, 139 ] ], "normalized": [] }, { "id": "NCT02762851_exc_T6", "type": "Condition", "text": [ "hives" ], "offsets": [ [ 154, 159 ] ], "normalized": [] }, { "id": "NCT02762851_exc_T7", "type": "Condition", "text": [ "swelling of the mouth and throat" ], "offsets": [ [ 161, 193 ] ], "normalized": [] }, { "id": "NCT02762851_exc_T8", "type": "Condition", "text": [ "difficulty in breathing" ], "offsets": [ [ 195, 218 ] ], "normalized": [] }, { "id": "NCT02762851_exc_T9", "type": "Condition", "text": [ "hypotension" ], "offsets": [ [ 220, 231 ] ], "normalized": [] }, { "id": "NCT02762851_exc_T10", "type": "Condition", "text": [ "shock" ], "offsets": [ [ 236, 241 ] ], "normalized": [] }, { "id": "NCT02762851_exc_T11", "type": "Scope", "text": [ "hives, swelling of the mouth and throat, difficulty in breathing, hypotension, or shock" ], "offsets": [ [ 154, 241 ] ], "normalized": [] }, { "id": "NCT02762851_exc_T12", "type": "Condition", "text": [ "Guillain-Barré syndrome" ], "offsets": [ [ 242, 265 ] ], "normalized": [] }, { "id": "NCT02762851_exc_T13", "type": "Temporal", "text": [ "within eight weeks of a previous influenza vaccine" ], "offsets": [ [ 266, 316 ] ], "normalized": [] }, { "id": "NCT02762851_exc_T14", "type": "Reference_point", "text": [ "a previous influenza vaccine" ], "offsets": [ [ 288, 316 ] ], "normalized": [] }, { "id": "NCT02762851_exc_T15", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 290, 298 ] ], "normalized": [] }, { "id": "NCT02762851_exc_T16", "type": "Drug", "text": [ "influenza vaccine" ], "offsets": [ [ 299, 316 ] ], "normalized": [] }, { "id": "NCT02762851_exc_T17", "type": "Condition", "text": [ "Anaphylactic reaction" ], "offsets": [ [ 317, 338 ] ], "normalized": [] }, { "id": "NCT02762851_exc_T18", "type": "Drug", "text": [ "neomycin" ], "offsets": [ [ 342, 350 ] ], "normalized": [] }, { "id": "NCT02762851_exc_T19", "type": "Drug", "text": [ "influenza vaccine" ], "offsets": [ [ 373, 390 ] ], "normalized": [] }, { "id": "NCT02762851_exc_T20", "type": "Temporal", "text": [ "in two of the three previous years" ], "offsets": [ [ 391, 425 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02762851_exc_R1", "type": "Subsumes", "arg1_id": "NCT02762851_exc_T3", "arg2_id": "NCT02762851_exc_T2", "normalized": [] }, { "id": "NCT02762851_exc_R2", "type": "AND", "arg1_id": "NCT02762851_exc_T1", "arg2_id": "NCT02762851_exc_T3", "normalized": [] }, { "id": "NCT02762851_exc_R3", "type": "AND", "arg1_id": "NCT02762851_exc_T4", "arg2_id": "NCT02762851_exc_T5", "normalized": [] }, { "id": "NCT02762851_exc_R4", "type": "Has_scope", "arg1_id": "NCT02762851_exc_T4", "arg2_id": "NCT02762851_exc_T11", "normalized": [] }, { "id": "NCT02762851_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02762851_exc_T16", "arg2_id": "NCT02762851_exc_T15", "normalized": [] }, { "id": "NCT02762851_exc_R6", "type": "AND", "arg1_id": "NCT02762851_exc_T14", "arg2_id": "NCT02762851_exc_T16", "normalized": [] }, { "id": "NCT02762851_exc_R7", "type": "Has_index", "arg1_id": "NCT02762851_exc_T13", "arg2_id": "NCT02762851_exc_T14", "normalized": [] }, { "id": "NCT02762851_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02762851_exc_T12", "arg2_id": "NCT02762851_exc_T13", "normalized": [] }, { "id": "NCT02762851_exc_R9", "type": "AND", "arg1_id": "NCT02762851_exc_T17", "arg2_id": "NCT02762851_exc_T18", "normalized": [] }, { "id": "NCT02762851_exc_R10", "type": "Has_temporal", "arg1_id": "NCT02762851_exc_T19", "arg2_id": "NCT02762851_exc_T20", "normalized": [] } ]

[ { "id": "NCT02762851_inc_text", "type": "inclusion", "text": [ "Age = 18 years and NYHA (New York Heart Association) functional class II, III and IV\n" ], "offsets": [ [ 0, 85 ] ] } ]

[ { "id": "NCT02762851_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02762851_inc_T2", "type": "Value", "text": [ "= 18 years" ], "offsets": [ [ 4, 14 ] ], "normalized": [] }, { "id": "NCT02762851_inc_T3", "type": "Measurement", "text": [ "NYHA (New York Heart Association) functional class" ], "offsets": [ [ 19, 69 ] ], "normalized": [] }, { "id": "NCT02762851_inc_T4", "type": "Value", "text": [ "II, III and IV" ], "offsets": [ [ 70, 84 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02762851_inc_R1", "type": "Has_value", "arg1_id": "NCT02762851_inc_T1", "arg2_id": "NCT02762851_inc_T2", "normalized": [] }, { "id": "NCT02762851_inc_R2", "type": "Has_value", "arg1_id": "NCT02762851_inc_T3", "arg2_id": "NCT02762851_inc_T4", "normalized": [] } ]

[ { "id": "NCT02763007_exc_text", "type": "exclusion", "text": [ "eGFR(Epidermal growth factor receptor) < 50mL/min\nAST(aspartate aminotransferase)/ALT(alanine aminotransaminase) >2.5 upper limit of normal\nPregnant or lactating women\nSubject who the investigator deems inappropriate to participate in this study\nPatients with a history of bladder cancer or patients with active bladder cancer\nPatients with uninvestigated macroscopic hematuria\nPatients with cardiac failure or a history of cardiac failure (New York Heart Association [NYHA] Stages 3 to 4)\nPatients with genetic problems such as galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption, since this study drug contains lactose\n" ], "offsets": [ [ 0, 651 ] ] } ]

[ { "id": "NCT02763007_exc_T1", "type": "Measurement", "text": [ "eGFR" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T2", "type": "Measurement", "text": [ "Epidermal growth factor receptor" ], "offsets": [ [ 5, 37 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T3", "type": "Value", "text": [ "< 50mL/min" ], "offsets": [ [ 39, 49 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T4", "type": "Measurement", "text": [ "AST" ], "offsets": [ [ 50, 53 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T5", "type": "Measurement", "text": [ "aspartate aminotransferase" ], "offsets": [ [ 54, 80 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T6", "type": "Measurement", "text": [ "ALT" ], "offsets": [ [ 82, 85 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T7", "type": "Measurement", "text": [ "alanine aminotransaminase" ], "offsets": [ [ 86, 111 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T8", "type": "Value", "text": [ ">2.5 upper limit of normal" ], "offsets": [ [ 113, 139 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T9", "type": "Scope", "text": [ "AST(aspartate aminotransferase)/ALT(alanine aminotransaminase" ], "offsets": [ [ 50, 111 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T12", "type": "Condition", "text": [ "bladder cancer" ], "offsets": [ [ 273, 287 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T13", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 305, 311 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T14", "type": "Condition", "text": [ "bladder cancer" ], "offsets": [ [ 312, 326 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T15", "type": "Condition", "text": [ "macroscopic hematuria" ], "offsets": [ [ 356, 377 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T16", "type": "Qualifier", "text": [ "uninvestigated" ], "offsets": [ [ 341, 355 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T17", "type": "Condition", "text": [ "cardiac failure" ], "offsets": [ [ 392, 407 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T18", "type": "Observation", "text": [ "history of cardiac failure" ], "offsets": [ [ 413, 439 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T19", "type": "Measurement", "text": [ "rk Heart Association [NYHA", " 3 t" ], "offsets": [ [ 447, 473 ], [ 481, 485 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T20", "type": "Value", "text": [ "3 to 4" ], "offsets": [ [ 482, 488 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T21", "type": "Measurement", "text": [ "NYHA" ], "offsets": [ [ 469, 473 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T22", "type": "Scope", "text": [ "cardiac failure or a history of cardiac failure" ], "offsets": [ [ 392, 439 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T23", "type": "Condition", "text": [ "genetic problems" ], "offsets": [ [ 504, 520 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T24", "type": "Condition", "text": [ "galactose intolerance" ], "offsets": [ [ 529, 550 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T25", "type": "Condition", "text": [ "Lapp lactase deficiency" ], "offsets": [ [ 552, 575 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T26", "type": "Condition", "text": [ "glucose-galactose malabsorption" ], "offsets": [ [ 579, 610 ] ], "normalized": [] }, { "id": "NCT02763007_exc_T27", "type": "Scope", "text": [ "galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption" ], "offsets": [ [ 529, 610 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02763007_exc_R1", "type": "Subsumes", "arg1_id": "NCT02763007_exc_T1", "arg2_id": "NCT02763007_exc_T2", "normalized": [] }, { "id": "NCT02763007_exc_R2", "type": "Has_value", "arg1_id": "NCT02763007_exc_T1", "arg2_id": "NCT02763007_exc_T3", "normalized": [] }, { "id": "NCT02763007_exc_R3", "type": "Subsumes", "arg1_id": "NCT02763007_exc_T4", "arg2_id": "NCT02763007_exc_T5", "normalized": [] }, { "id": "NCT02763007_exc_R4", "type": "Subsumes", "arg1_id": "NCT02763007_exc_T6", "arg2_id": "NCT02763007_exc_T7", "normalized": [] }, { "id": "NCT02763007_exc_R5", "type": "Has_value", "arg1_id": "NCT02763007_exc_T9", "arg2_id": "NCT02763007_exc_T8", "normalized": [] }, { "id": "NCT02763007_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02763007_exc_T14", "arg2_id": "NCT02763007_exc_T13", "normalized": [] }, { "id": "NCT02763007_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT02763007_exc_T15", "arg2_id": "NCT02763007_exc_T16", "normalized": [] }, { "id": "NCT02763007_exc_R8", "type": "Subsumes", "arg1_id": "NCT02763007_exc_T19", "arg2_id": "NCT02763007_exc_T21", "normalized": [] }, { "id": "NCT02763007_exc_R9", "type": "Has_value", "arg1_id": "NCT02763007_exc_T19", "arg2_id": "NCT02763007_exc_T20", "normalized": [] }, { "id": "NCT02763007_exc_R10", "type": "AND", "arg1_id": "NCT02763007_exc_T22", "arg2_id": "NCT02763007_exc_T19", "normalized": [] }, { "id": "NCT02763007_exc_R11", "type": "Subsumes", "arg1_id": "NCT02763007_exc_T23", "arg2_id": "NCT02763007_exc_T27", "normalized": [] } ]

[ { "id": "NCT02763007_inc_text", "type": "inclusion", "text": [ "Completed \"ALO-IIT-012(PEAK study)\", without major protocol deviations.\nMale, or female, 19 years to 75 years.\nFemale with childbearing potential who has a negative urine pregnancy test result at study start and willing to continue practice appropriate birth control during the entire duration of study\nSubjects completed PEAK can be included within 30 days after End Of the Study\nSubjects completed PEAK can be included if their treatment is the same as randomized even after 30 days of End Of the Study.\n" ], "offsets": [ [ 0, 506 ] ] } ]

[ { "id": "NCT02763007_inc_T2", "type": "Person", "text": [ "Male" ], "offsets": [ [ 72, 76 ] ], "normalized": [] }, { "id": "NCT02763007_inc_T3", "type": "Person", "text": [ "female" ], "offsets": [ [ 81, 87 ] ], "normalized": [] }, { "id": "NCT02763007_inc_T4", "type": "Person", "text": [ "years" ], "offsets": [ [ 104, 109 ] ], "normalized": [] }, { "id": "NCT02763007_inc_T5", "type": "Value", "text": [ "19 years to 75" ], "offsets": [ [ 89, 103 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02763007_inc_R1", "type": "Has_value", "arg1_id": "NCT02763007_inc_T4", "arg2_id": "NCT02763007_inc_T5", "normalized": [] } ]

[ { "id": "NCT02764476_exc_text", "type": "exclusion", "text": [ "Nonfluency or inability to communicate in English spoken language \nInability to participate or attend biweekly 30 minute session over 14 weeks \nFrank psychosis \nActive self harm urges \nSerious medical illness \nActive substance or alcohol use or dependence that could interfere with participation \nDiagnoses of mental retardation, dementia or delirium \nPregnant women \n \n" ], "offsets": [ [ 0, 379 ] ] } ]

[ { "id": "NCT02764476_exc_T3", "type": "Condition", "text": [ "psychosis" ], "offsets": [ [ 150, 159 ] ], "normalized": [] }, { "id": "NCT02764476_exc_T4", "type": "Qualifier", "text": [ "Frank" ], "offsets": [ [ 144, 149 ] ], "normalized": [] }, { "id": "NCT02764476_exc_T5", "type": "Condition", "text": [ "self harm urges" ], "offsets": [ [ 168, 183 ] ], "normalized": [] }, { "id": "NCT02764476_exc_T6", "type": "Temporal", "text": [ "Active" ], "offsets": [ [ 161, 167 ] ], "normalized": [] }, { "id": "NCT02764476_exc_T7", "type": "Condition", "text": [ "medical illness" ], "offsets": [ [ 193, 208 ] ], "normalized": [] }, { "id": "NCT02764476_exc_T8", "type": "Qualifier", "text": [ "Serious" ], "offsets": [ [ 185, 192 ] ], "normalized": [] }, { "id": "NCT02764476_exc_T12", "type": "Condition", "text": [ "substance", "use or dependence" ], "offsets": [ [ 217, 226 ], [ 238, 255 ] ], "normalized": [] }, { "id": "NCT02764476_exc_T13", "type": "Condition", "text": [ "alcohol use or dependence" ], "offsets": [ [ 230, 255 ] ], "normalized": [] }, { "id": "NCT02764476_exc_T16", "type": "Condition", "text": [ "mental retardation" ], "offsets": [ [ 310, 328 ] ], "normalized": [] }, { "id": "NCT02764476_exc_T17", "type": "Condition", "text": [ "dementia" ], "offsets": [ [ 330, 338 ] ], "normalized": [] }, { "id": "NCT02764476_exc_T18", "type": "Condition", "text": [ "delirium" ], "offsets": [ [ 342, 350 ] ], "normalized": [] }, { "id": "NCT02764476_exc_T19", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 352, 360 ] ], "normalized": [] }, { "id": "NCT02764476_exc_T20", "type": "Person", "text": [ "women" ], "offsets": [ [ 361, 366 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02764476_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02764476_exc_T3", "arg2_id": "NCT02764476_exc_T4", "normalized": [] }, { "id": "NCT02764476_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02764476_exc_T7", "arg2_id": "NCT02764476_exc_T8", "normalized": [] }, { "id": "NCT02764476_exc_R5", "type": "AND", "arg1_id": "NCT02764476_exc_T20", "arg2_id": "NCT02764476_exc_T19", "normalized": [] } ]

[ { "id": "NCT02764476_inc_text", "type": "inclusion", "text": [ "Adults 18-65 years, who are diagnosed with functional neurologic symptom or conversion disorder. If diagnosis of seizure type then video EEG with diagnosis confirmed by board-certified neurologist with subspecialty training in epilepsy and clinical neurophysiology using the criteria of the International Classification of the Epilepsies is required. If diagnosis of motor type, documented and clinically established levels of diagnostic certainty (Williams,1995) confirmed by 2 neurologists is required. \nParticipants must have at least one symptom per month in the month prior to enrollment \nFluency in English spoken language \n" ], "offsets": [ [ 0, 630 ] ] } ]

[ { "id": "NCT02764476_inc_T1", "type": "Value", "text": [ "18-65 years" ], "offsets": [ [ 7, 18 ] ], "normalized": [] }, { "id": "NCT02764476_inc_T2", "type": "Person", "text": [ "Adults" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "NCT02764476_inc_T3", "type": "Person", "text": [ "18-65 years" ], "offsets": [ [ 7, 18 ] ], "normalized": [] }, { "id": "NCT02764476_inc_T4", "type": "Condition", "text": [ "functional neurologic symptom" ], "offsets": [ [ 43, 72 ] ], "normalized": [] }, { "id": "NCT02764476_inc_T5", "type": "Condition", "text": [ "conversion disorder" ], "offsets": [ [ 76, 95 ] ], "normalized": [] }, { "id": "NCT02764476_inc_T6", "type": "Condition", "text": [ "seizure type" ], "offsets": [ [ 113, 125 ] ], "normalized": [] }, { "id": "NCT02764476_inc_T7", "type": "Procedure", "text": [ "video EEG" ], "offsets": [ [ 131, 140 ] ], "normalized": [] }, { "id": "NCT02764476_inc_T8", "type": "Measurement", "text": [ "criteria of the International Classification of the Epilepsies" ], "offsets": [ [ 275, 337 ] ], "normalized": [] }, { "id": "NCT02764476_inc_T9", "type": "Condition", "text": [ "motor type" ], "offsets": [ [ 367, 377 ] ], "normalized": [] }, { "id": "NCT02764476_inc_T11", "type": "Condition", "text": [ "symptom" ], "offsets": [ [ 542, 549 ] ], "normalized": [] }, { "id": "NCT02764476_inc_T12", "type": "Multiplier", "text": [ "at least one", "per month" ], "offsets": [ [ 529, 541 ], [ 550, 559 ] ], "normalized": [] }, { "id": "NCT02764476_inc_T13", "type": "Temporal", "text": [ "in the month prior to enrollment" ], "offsets": [ [ 560, 592 ] ], "normalized": [] }, { "id": "NCT02764476_inc_T14", "type": "Reference_point", "text": [ "to enrollment" ], "offsets": [ [ 579, 592 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02764476_inc_R1", "type": "Has_value", "arg1_id": "NCT02764476_inc_T3", "arg2_id": "NCT02764476_inc_T1", "normalized": [] }, { "id": "NCT02764476_inc_R2", "type": "AND", "arg1_id": "NCT02764476_inc_T7", "arg2_id": "NCT02764476_inc_T8", "normalized": [] }, { "id": "NCT02764476_inc_R3", "type": "AND", "arg1_id": "NCT02764476_inc_T6", "arg2_id": "NCT02764476_inc_T7", "normalized": [] }, { "id": "NCT02764476_inc_R4", "type": "Has_multiplier", "arg1_id": "NCT02764476_inc_T11", "arg2_id": "NCT02764476_inc_T12", "normalized": [] }, { "id": "NCT02764476_inc_R5", "type": "Has_index", "arg1_id": "NCT02764476_inc_T13", "arg2_id": "NCT02764476_inc_T14", "normalized": [] } ]

[ { "id": "NCT02765035_exc_text", "type": "exclusion", "text": [ "Person is under 18 years of age.\nPerson who weighs more than 136kg.\nPerson who weighs less than 50kg.\nPerson who is pregnant.\nPerson has a history of chronic skin breakdown on the residual limb.\nPerson has conditions that would prevent participation and pose increased risk (e.g. unstable cardiovascular conditions that preclude physical activity such as walking).\nPerson falls = once a week due to the reasons that could not be corrected by the new prosthesis (for ex. problems with vestibular system).\nPerson is using under arm axillary crutches or walker.\nPerson in an emergency, life threatening situation.\nPerson is unwilling/unable to follow instructions.\nPerson who is not available to follow the entire study protocol.\nPerson who is participating in another study or intends to participate in another study during this study duration.\nPerson who cannot personally provide their consent.\nPerson who is not wearing prosthesis 8hours/day on average.\nPerson who has a score on 10m walk test less than 3km/h (~0.8m/s) (based on 10m walk test conducted during recruiting).\nPerson who walks on average less than 1km per day.\nPerson who is not able to walk on level ground in a step over step manner.\n" ], "offsets": [ [ 0, 1201 ] ] } ]

[ { "id": "NCT02765035_exc_T1", "type": "Person", "text": [ "age" ], "offsets": [ [ 28, 31 ] ], "normalized": [] }, { "id": "NCT02765035_exc_T2", "type": "Value", "text": [ "under 18 years" ], "offsets": [ [ 10, 24 ] ], "normalized": [] }, { "id": "NCT02765035_exc_T3", "type": "Person", "text": [ "weighs" ], "offsets": [ [ 44, 50 ] ], "normalized": [] }, { "id": "NCT02765035_exc_T4", "type": "Value", "text": [ "more than 136kg" ], "offsets": [ [ 51, 66 ] ], "normalized": [] }, { "id": "NCT02765035_exc_T5", "type": "Person", "text": [ "weighs" ], "offsets": [ [ 79, 85 ] ], "normalized": [] }, { "id": "NCT02765035_exc_T6", "type": "Value", "text": [ "less than 50kg" ], "offsets": [ [ 86, 100 ] ], "normalized": [] }, { "id": "NCT02765035_exc_T7", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 116, 124 ] ], "normalized": [] }, { "id": "NCT02765035_exc_T8", "type": "Condition", "text": [ "skin breakdown" ], "offsets": [ [ 158, 172 ] ], "normalized": [] }, { "id": "NCT02765035_exc_T9", "type": "Qualifier", "text": [ "chronic" ], "offsets": [ [ 150, 157 ] ], "normalized": [] }, { "id": "NCT02765035_exc_T10", "type": "Qualifier", "text": [ "residual limb" ], "offsets": [ [ 180, 193 ] ], "normalized": [] }, { "id": "NCT02765035_exc_T12", "type": "Observation", "text": [ "falls" ], "offsets": [ [ 372, 377 ] ], "normalized": [] }, { "id": "NCT02765035_exc_T13", "type": "Multiplier", "text": [ "once a week" ], "offsets": [ [ 380, 391 ] ], "normalized": [] }, { "id": "NCT02765035_exc_T15", "type": "Device", "text": [ "under arm axillary crutches" ], "offsets": [ [ 520, 547 ] ], "normalized": [] }, { "id": "NCT02765035_exc_T16", "type": "Device", "text": [ "walker" ], "offsets": [ [ 551, 557 ] ], "normalized": [] }, { "id": "NCT02765035_exc_T17", "type": "Observation", "text": [ "life threatening situation" ], "offsets": [ [ 583, 609 ] ], "normalized": [] }, { "id": "NCT02765035_exc_T18", "type": "Observation", "text": [ "y, life t", "n.\nPerson" ], "offsets": [ [ 580, 589 ], [ 608, 617 ] ], "normalized": [] }, { "id": "NCT02765035_exc_T23", "type": "Negation", "text": [ "not" ], "offsets": [ [ 909, 912 ] ], "normalized": [] }, { "id": "NCT02765035_exc_T24", "type": "Device", "text": [ "prosthesis" ], "offsets": [ [ 921, 931 ] ], "normalized": [] }, { "id": "NCT02765035_exc_T25", "type": "Multiplier", "text": [ "8hours/day" ], "offsets": [ [ 932, 942 ] ], "normalized": [] }, { "id": "NCT02765035_exc_T26", "type": "Measurement", "text": [ "10m walk test" ], "offsets": [ [ 981, 994 ] ], "normalized": [] }, { "id": "NCT02765035_exc_T27", "type": "Value", "text": [ "less than 3km/h" ], "offsets": [ [ 995, 1010 ] ], "normalized": [] }, { "id": "NCT02765035_exc_T28", "type": "Value", "text": [ "0.8m/s)" ], "offsets": [ [ 1013, 1020 ] ], "normalized": [] }, { "id": "NCT02765035_exc_T29", "type": "Observation", "text": [ "walks" ], "offsets": [ [ 1086, 1091 ] ], "normalized": [] }, { "id": "NCT02765035_exc_T30", "type": "Multiplier", "text": [ "ess than 1km per day" ], "offsets": [ [ 1104, 1124 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02765035_exc_R1", "type": "Has_value", "arg1_id": "NCT02765035_exc_T1", "arg2_id": "NCT02765035_exc_T2", "normalized": [] }, { "id": "NCT02765035_exc_R2", "type": "Has_value", "arg1_id": "NCT02765035_exc_T3", "arg2_id": "NCT02765035_exc_T4", "normalized": [] }, { "id": "NCT02765035_exc_R3", "type": "Has_value", "arg1_id": "NCT02765035_exc_T5", "arg2_id": "NCT02765035_exc_T6", "normalized": [] }, { "id": "NCT02765035_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT02765035_exc_T8", "arg2_id": "NCT02765035_exc_T9", "normalized": [] }, { "id": "NCT02765035_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02765035_exc_T8", "arg2_id": "NCT02765035_exc_T10", "normalized": [] }, { "id": "NCT02765035_exc_R6", "type": "Has_multiplier", "arg1_id": "NCT02765035_exc_T12", "arg2_id": "NCT02765035_exc_T13", "normalized": [] }, { "id": "NCT02765035_exc_R7", "type": "Has_negation", "arg1_id": "NCT02765035_exc_T24", "arg2_id": "NCT02765035_exc_T23", "normalized": [] }, { "id": "NCT02765035_exc_R8", "type": "Has_multiplier", "arg1_id": "NCT02765035_exc_T24", "arg2_id": "NCT02765035_exc_T25", "normalized": [] }, { "id": "NCT02765035_exc_R9", "type": "Subsumes", "arg1_id": "NCT02765035_exc_T27", "arg2_id": "NCT02765035_exc_T28", "normalized": [] }, { "id": "NCT02765035_exc_R10", "type": "Has_value", "arg1_id": "NCT02765035_exc_T26", "arg2_id": "NCT02765035_exc_T27", "normalized": [] }, { "id": "NCT02765035_exc_R11", "type": "Has_multiplier", "arg1_id": "NCT02765035_exc_T29", "arg2_id": "NCT02765035_exc_T30", "normalized": [] } ]

[ { "id": "NCT02765035_inc_text", "type": "inclusion", "text": [ "Person is >18 years old.\nPerson is a unilateral transfemoral or knee-disarticulation amputee with stabilized residual limb.\nPerson is a K2, K3 or K4 ambulator based on Medicare Functional Classification Level (MFCL).\nPerson is currently fitted with a prosthesis using a non-microprocessor controlled prosthetic knee for at least 6 months.\nPerson was never fitted with microprocessor controlled prosthetic knee joint.\nPerson is willing and able to independently provide informed consent.\nPerson is willing to comply with study procedures.\nPerson wears prosthesis daily and = 8 hours/day.\nPerson is walking on average 1km/day.\nPerson is walking not slower than 3km/h (~0.8m/s) (based on 10m walk test conducted during recruiting).\nPerson is walking on level ground in a step over step manner.\n" ], "offsets": [ [ 0, 791 ] ] } ]

[ { "id": "NCT02765035_inc_T1", "type": "Person", "text": [ "old" ], "offsets": [ [ 20, 23 ] ], "normalized": [] }, { "id": "NCT02765035_inc_T2", "type": "Value", "text": [ ">18 years" ], "offsets": [ [ 10, 19 ] ], "normalized": [] }, { "id": "NCT02765035_inc_T4", "type": "Measurement", "text": [ "Medicare Functional Classification Level" ], "offsets": [ [ 168, 208 ] ], "normalized": [] }, { "id": "NCT02765035_inc_T5", "type": "Measurement", "text": [ "MFCL" ], "offsets": [ [ 210, 214 ] ], "normalized": [] }, { "id": "NCT02765035_inc_T6", "type": "Value", "text": [ "K2, K3 or K4" ], "offsets": [ [ 136, 148 ] ], "normalized": [] }, { "id": "NCT02765035_inc_T7", "type": "Device", "text": [ "prosthesis" ], "offsets": [ [ 251, 261 ] ], "normalized": [] }, { "id": "NCT02765035_inc_T8", "type": "Device", "text": [ "prosthetic knee" ], "offsets": [ [ 300, 315 ] ], "normalized": [] }, { "id": "NCT02765035_inc_T9", "type": "Qualifier", "text": [ "non-microprocessor controlled" ], "offsets": [ [ 270, 299 ] ], "normalized": [] }, { "id": "NCT02765035_inc_T10", "type": "Temporal", "text": [ "at least 6 months" ], "offsets": [ [ 320, 337 ] ], "normalized": [] }, { "id": "NCT02765035_inc_T11", "type": "Negation", "text": [ "never" ], "offsets": [ [ 350, 355 ] ], "normalized": [] }, { "id": "NCT02765035_inc_T12", "type": "Device", "text": [ "prosthetic knee joint" ], "offsets": [ [ 394, 415 ] ], "normalized": [] }, { "id": "NCT02765035_inc_T13", "type": "Qualifier", "text": [ "microprocessor controlled" ], "offsets": [ [ 368, 393 ] ], "normalized": [] }, { "id": "NCT02765035_inc_T16", "type": "Device", "text": [ "prosthesis" ], "offsets": [ [ 551, 561 ] ], "normalized": [] }, { "id": "NCT02765035_inc_T17", "type": "Multiplier", "text": [ "daily and = 8 hours/day" ], "offsets": [ [ 562, 585 ] ], "normalized": [] }, { "id": "NCT02765035_inc_T18", "type": "Observation", "text": [ "walking" ], "offsets": [ [ 597, 604 ] ], "normalized": [] }, { "id": "NCT02765035_inc_T19", "type": "Multiplier", "text": [ "1km/day" ], "offsets": [ [ 616, 623 ] ], "normalized": [] }, { "id": "NCT02765035_inc_T20", "type": "Observation", "text": [ "walking" ], "offsets": [ [ 635, 642 ] ], "normalized": [] }, { "id": "NCT02765035_inc_T21", "type": "Multiplier", "text": [ "not slower than 3km/h" ], "offsets": [ [ 643, 664 ] ], "normalized": [] }, { "id": "NCT02765035_inc_T22", "type": "Observation", "text": [ "walking" ], "offsets": [ [ 739, 746 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02765035_inc_R1", "type": "Has_value", "arg1_id": "NCT02765035_inc_T1", "arg2_id": "NCT02765035_inc_T2", "normalized": [] }, { "id": "NCT02765035_inc_R2", "type": "Subsumes", "arg1_id": "NCT02765035_inc_T4", "arg2_id": "NCT02765035_inc_T5", "normalized": [] }, { "id": "NCT02765035_inc_R3", "type": "Has_value", "arg1_id": "NCT02765035_inc_T4", "arg2_id": "NCT02765035_inc_T6", "normalized": [] }, { "id": "NCT02765035_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT02765035_inc_T8", "arg2_id": "NCT02765035_inc_T9", "normalized": [] }, { "id": "NCT02765035_inc_R5", "type": "AND", "arg1_id": "NCT02765035_inc_T7", "arg2_id": "NCT02765035_inc_T8", "normalized": [] }, { "id": "NCT02765035_inc_R6", "type": "Has_temporal", "arg1_id": "NCT02765035_inc_T8", "arg2_id": "NCT02765035_inc_T10", "normalized": [] }, { "id": "NCT02765035_inc_R7", "type": "Has_qualifier", "arg1_id": "NCT02765035_inc_T12", "arg2_id": "NCT02765035_inc_T13", "normalized": [] }, { "id": "NCT02765035_inc_R8", "type": "Has_negation", "arg1_id": "NCT02765035_inc_T12", "arg2_id": "NCT02765035_inc_T11", "normalized": [] }, { "id": "NCT02765035_inc_R9", "type": "Has_multiplier", "arg1_id": "NCT02765035_inc_T16", "arg2_id": "NCT02765035_inc_T17", "normalized": [] }, { "id": "NCT02765035_inc_R10", "type": "Has_multiplier", "arg1_id": "NCT02765035_inc_T18", "arg2_id": "NCT02765035_inc_T19", "normalized": [] }, { "id": "NCT02765035_inc_R11", "type": "Has_multiplier", "arg1_id": "NCT02765035_inc_T20", "arg2_id": "NCT02765035_inc_T21", "normalized": [] } ]

[ { "id": "NCT02765217_exc_text", "type": "exclusion", "text": [ "Receiving antibiotic and/or probiotic, 8 weeks before the study\nChronic gastrointestinal system disorders\nCongenital anomalies\nChronic diseases\nChemotherapy and radiotherapy\nPregnancy\n" ], "offsets": [ [ 0, 184 ] ] } ]

[ { "id": "NCT02765217_exc_T1", "type": "Drug", "text": [ "antibiotic" ], "offsets": [ [ 10, 20 ] ], "normalized": [] }, { "id": "NCT02765217_exc_T2", "type": "Drug", "text": [ "probiotic" ], "offsets": [ [ 28, 37 ] ], "normalized": [] }, { "id": "NCT02765217_exc_T3", "type": "Temporal", "text": [ "8 weeks before the study" ], "offsets": [ [ 39, 63 ] ], "normalized": [] }, { "id": "NCT02765217_exc_T4", "type": "Reference_point", "text": [ "the study" ], "offsets": [ [ 54, 63 ] ], "normalized": [] }, { "id": "NCT02765217_exc_T5", "type": "Scope", "text": [ "antibiotic and/or probiotic" ], "offsets": [ [ 10, 37 ] ], "normalized": [] }, { "id": "NCT02765217_exc_T6", "type": "Condition", "text": [ "Chronic gastrointestinal system disorders" ], "offsets": [ [ 64, 105 ] ], "normalized": [] }, { "id": "NCT02765217_exc_T7", "type": "Condition", "text": [ "Congenital anomalies" ], "offsets": [ [ 106, 126 ] ], "normalized": [] }, { "id": "NCT02765217_exc_T8", "type": "Condition", "text": [ "Chronic diseases" ], "offsets": [ [ 127, 143 ] ], "normalized": [] }, { "id": "NCT02765217_exc_T9", "type": "Procedure", "text": [ "Chemotherapy" ], "offsets": [ [ 144, 156 ] ], "normalized": [] }, { "id": "NCT02765217_exc_T10", "type": "Procedure", "text": [ "radiotherapy" ], "offsets": [ [ 161, 173 ] ], "normalized": [] }, { "id": "NCT02765217_exc_T11", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 174, 183 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02765217_exc_R1", "type": "Has_index", "arg1_id": "NCT02765217_exc_T3", "arg2_id": "NCT02765217_exc_T4", "normalized": [] }, { "id": "NCT02765217_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02765217_exc_T5", "arg2_id": "NCT02765217_exc_T3", "normalized": [] } ]

[ { "id": "NCT02765217_inc_text", "type": "inclusion", "text": [ "Children receiving amoxicilline-clavulanic acid (50-90 mg/kg/day, twice daily) due to acute otitis media or acute sinusitis\n" ], "offsets": [ [ 0, 124 ] ] } ]

[ { "id": "NCT02765217_inc_T1", "type": "Drug", "text": [ "amoxicilline-clavulanic acid" ], "offsets": [ [ 19, 47 ] ], "normalized": [] }, { "id": "NCT02765217_inc_T2", "type": "Person", "text": [ "Children" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT02765217_inc_T3", "type": "Value", "text": [ "50-90 mg/kg/day" ], "offsets": [ [ 49, 64 ] ], "normalized": [] }, { "id": "NCT02765217_inc_T4", "type": "Multiplier", "text": [ "twice daily" ], "offsets": [ [ 66, 77 ] ], "normalized": [] }, { "id": "NCT02765217_inc_T5", "type": "Condition", "text": [ "acute otitis media" ], "offsets": [ [ 86, 104 ] ], "normalized": [] }, { "id": "NCT02765217_inc_T6", "type": "Condition", "text": [ "acute sinusitis" ], "offsets": [ [ 108, 123 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02765217_inc_R1", "type": "Has_value", "arg1_id": "NCT02765217_inc_T1", "arg2_id": "NCT02765217_inc_T3", "normalized": [] }, { "id": "NCT02765217_inc_R2", "type": "Has_multiplier", "arg1_id": "NCT02765217_inc_T1", "arg2_id": "NCT02765217_inc_T4", "normalized": [] } ]

[ { "id": "NCT02766530_exc_text", "type": "exclusion", "text": [ "Estimated GFR (eGFR) < 60 mL/min/1.73 m2 and blood glucose > 135 mg/dl; Past or present history of acute renal failure, renal dialysis, diabetes mellitus.\nWomen who received metallic fixation, coronary artery stent in recent 3 months; or women who received mechanical valve replacement that is not compatible with MR magnet; or women with aneurysmal clips, pacemakers.\nPast history of claustrophobia.\nWomen who are pregnant or who are planning to be pregnant, or who are lactating (though the possibility in our target population should be very low)\nPast history of breast cancer within recent 5 years before the currently diagnosed breast cancer.\nWomen who received chemotherapy for other disease entity in recent 1 year.\nWomen who cannot cooperate with the examinations.\n" ], "offsets": [ [ 0, 773 ] ] } ]

[ { "id": "NCT02766530_exc_T1", "type": "Measurement", "text": [ "Estimated GFR" ], "offsets": [ [ 0, 13 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T2", "type": "Measurement", "text": [ "eGFR" ], "offsets": [ [ 15, 19 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T3", "type": "Value", "text": [ "< 60 mL/min/1.73 m2" ], "offsets": [ [ 21, 40 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T4", "type": "Measurement", "text": [ "blood glucose" ], "offsets": [ [ 45, 58 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T5", "type": "Value", "text": [ "> 135 mg/dl" ], "offsets": [ [ 59, 70 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T6", "type": "Condition", "text": [ "acute renal failure" ], "offsets": [ [ 99, 118 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T7", "type": "Procedure", "text": [ "renal dialysis" ], "offsets": [ [ 120, 134 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T8", "type": "Condition", "text": [ "diabetes mellitus" ], "offsets": [ [ 136, 153 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T9", "type": "Person", "text": [ "Women" ], "offsets": [ [ 155, 160 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T10", "type": "Procedure", "text": [ "metallic fixation" ], "offsets": [ [ 174, 191 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T11", "type": "Device", "text": [ "coronary artery stent" ], "offsets": [ [ 193, 214 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T12", "type": "Temporal", "text": [ "recent 3 months" ], "offsets": [ [ 218, 233 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T13", "type": "Person", "text": [ "women" ], "offsets": [ [ 238, 243 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T14", "type": "Device", "text": [ "mechanical valve replacement" ], "offsets": [ [ 257, 285 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T15", "type": "Person", "text": [ "women" ], "offsets": [ [ 328, 333 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T16", "type": "Device", "text": [ "aneurysmal clips" ], "offsets": [ [ 339, 355 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T17", "type": "Device", "text": [ "pacemakers" ], "offsets": [ [ 357, 367 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T18", "type": "Scope", "text": [ "aneurysmal clips, pacemakers" ], "offsets": [ [ 339, 367 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T19", "type": "Scope", "text": [ "metallic fixation, coronary artery stent" ], "offsets": [ [ 174, 214 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T20", "type": "Condition", "text": [ "claustrophobia" ], "offsets": [ [ 385, 399 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T22", "type": "Condition", "text": [ "breast cancer" ], "offsets": [ [ 566, 579 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T23", "type": "Temporal", "text": [ "recent 5 years before the currently diagnosed breast cancer" ], "offsets": [ [ 587, 646 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T24", "type": "Reference_point", "text": [ "currently diagnosed breast cancer." ], "offsets": [ [ 613, 647 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T25", "type": "Procedure", "text": [ "chemotherapy" ], "offsets": [ [ 667, 679 ] ], "normalized": [] }, { "id": "NCT02766530_exc_T26", "type": "Temporal", "text": [ "recent 1 year" ], "offsets": [ [ 708, 721 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02766530_exc_R1", "type": "Subsumes", "arg1_id": "NCT02766530_exc_T1", "arg2_id": "NCT02766530_exc_T2", "normalized": [] }, { "id": "NCT02766530_exc_R2", "type": "Has_value", "arg1_id": "NCT02766530_exc_T1", "arg2_id": "NCT02766530_exc_T3", "normalized": [] }, { "id": "NCT02766530_exc_R3", "type": "Has_value", "arg1_id": "NCT02766530_exc_T4", "arg2_id": "NCT02766530_exc_T5", "normalized": [] }, { "id": "NCT02766530_exc_R4", "type": "Has_scope", "arg1_id": "NCT02766530_exc_T15", "arg2_id": "NCT02766530_exc_T18", "normalized": [] }, { "id": "NCT02766530_exc_R5", "type": "AND", "arg1_id": "NCT02766530_exc_T13", "arg2_id": "NCT02766530_exc_T14", "normalized": [] }, { "id": "NCT02766530_exc_R6", "type": "Has_temporal", "arg1_id": "NCT02766530_exc_T19", "arg2_id": "NCT02766530_exc_T12", "normalized": [] }, { "id": "NCT02766530_exc_R7", "type": "Has_scope", "arg1_id": "NCT02766530_exc_T9", "arg2_id": "NCT02766530_exc_T19", "normalized": [] }, { "id": "NCT02766530_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02766530_exc_T22", "arg2_id": "NCT02766530_exc_T23", "normalized": [] }, { "id": "NCT02766530_exc_R9", "type": "Has_index", "arg1_id": "NCT02766530_exc_T23", "arg2_id": "NCT02766530_exc_T24", "normalized": [] }, { "id": "NCT02766530_exc_R10", "type": "Has_temporal", "arg1_id": "NCT02766530_exc_T25", "arg2_id": "NCT02766530_exc_T26", "normalized": [] } ]

[ { "id": "NCT02766530_inc_text", "type": "inclusion", "text": [ "Women aged 25-75 years old.\nWomen with recently diagnosed breast cancer and who will receive NAC to reduce tumor burden before surgery. (including locally advanced breast cancer (LABC) according to clinical assessment; or tumor size > 2cm, that is, at least T2 in TNM staging).\n" ], "offsets": [ [ 0, 278 ] ] } ]

[ { "id": "NCT02766530_inc_T1", "type": "Person", "text": [ "Women" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT02766530_inc_T2", "type": "Person", "text": [ "aged" ], "offsets": [ [ 6, 10 ] ], "normalized": [] }, { "id": "NCT02766530_inc_T3", "type": "Value", "text": [ "25-75 years old" ], "offsets": [ [ 11, 26 ] ], "normalized": [] }, { "id": "NCT02766530_inc_T4", "type": "Person", "text": [ "Women" ], "offsets": [ [ 28, 33 ] ], "normalized": [] }, { "id": "NCT02766530_inc_T5", "type": "Condition", "text": [ "breast cancer" ], "offsets": [ [ 58, 71 ] ], "normalized": [] }, { "id": "NCT02766530_inc_T6", "type": "Procedure", "text": [ "NAC" ], "offsets": [ [ 93, 96 ] ], "normalized": [] }, { "id": "NCT02766530_inc_T7", "type": "Qualifier", "text": [ "reduce tumor burden" ], "offsets": [ [ 100, 119 ] ], "normalized": [] }, { "id": "NCT02766530_inc_T8", "type": "Temporal", "text": [ "before surgery" ], "offsets": [ [ 120, 134 ] ], "normalized": [] }, { "id": "NCT02766530_inc_T9", "type": "Reference_point", "text": [ "surgery" ], "offsets": [ [ 127, 134 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02766530_inc_R1", "type": "Has_value", "arg1_id": "NCT02766530_inc_T2", "arg2_id": "NCT02766530_inc_T3", "normalized": [] }, { "id": "NCT02766530_inc_R2", "type": "Has_index", "arg1_id": "NCT02766530_inc_T8", "arg2_id": "NCT02766530_inc_T9", "normalized": [] }, { "id": "NCT02766530_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT02766530_inc_T6", "arg2_id": "NCT02766530_inc_T7", "normalized": [] }, { "id": "NCT02766530_inc_R4", "type": "AND", "arg1_id": "NCT02766530_inc_T5", "arg2_id": "NCT02766530_inc_T6", "normalized": [] }, { "id": "NCT02766530_inc_R5", "type": "Has_temporal", "arg1_id": "NCT02766530_inc_T6", "arg2_id": "NCT02766530_inc_T8", "normalized": [] } ]

[ { "id": "NCT02773173_exc_text", "type": "exclusion", "text": [ "Emergency surgery\nPregnancy or lactation\nImmune disorders\nKidney or liver disease or advanced-stage cardiopulmonary\nPatient refusal to participate in the study\nPatients under 18 years or inability to consent\nAssociated neuromuscular disorders, contraindication for the use of rocuronium/ sugammadex, allergy or hypersensitivity to rocuronium / sugammadex\n" ], "offsets": [ [ 0, 355 ] ] } ]

[ { "id": "NCT02773173_exc_T1", "type": "Procedure", "text": [ "Emergency surgery" ], "offsets": [ [ 0, 17 ] ], "normalized": [] }, { "id": "NCT02773173_exc_T2", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 18, 27 ] ], "normalized": [] }, { "id": "NCT02773173_exc_T3", "type": "Condition", "text": [ "lactation" ], "offsets": [ [ 31, 40 ] ], "normalized": [] }, { "id": "NCT02773173_exc_T4", "type": "Condition", "text": [ "Immune disorders" ], "offsets": [ [ 41, 57 ] ], "normalized": [] }, { "id": "NCT02773173_exc_T5", "type": "Condition", "text": [ "liver disease" ], "offsets": [ [ 68, 81 ] ], "normalized": [] }, { "id": "NCT02773173_exc_T6", "type": "Condition", "text": [ "ney or", "ease or" ], "offsets": [ [ 61, 67 ], [ 77, 84 ] ], "normalized": [] }, { "id": "NCT02773173_exc_T7", "type": "Condition", "text": [ "advanced-stage cardiopulmonary" ], "offsets": [ [ 85, 115 ] ], "normalized": [] }, { "id": "NCT02773173_exc_T9", "type": "Person", "text": [ "years" ], "offsets": [ [ 178, 183 ] ], "normalized": [] }, { "id": "NCT02773173_exc_T10", "type": "Value", "text": [ "under 18" ], "offsets": [ [ 169, 177 ] ], "normalized": [] }, { "id": "NCT02773173_exc_T11", "type": "Condition", "text": [ "inability to consent" ], "offsets": [ [ 187, 207 ] ], "normalized": [] }, { "id": "NCT02773173_exc_T13", "type": "Condition", "text": [ "neuromuscular disorders" ], "offsets": [ [ 219, 242 ] ], "normalized": [] }, { "id": "NCT02773173_exc_T14", "type": "Condition", "text": [ "contraindication" ], "offsets": [ [ 244, 260 ] ], "normalized": [] }, { "id": "NCT02773173_exc_T15", "type": "Drug", "text": [ "rocuronium" ], "offsets": [ [ 276, 286 ] ], "normalized": [] }, { "id": "NCT02773173_exc_T16", "type": "Drug", "text": [ "sugammadex" ], "offsets": [ [ 288, 298 ] ], "normalized": [] }, { "id": "NCT02773173_exc_T17", "type": "Scope", "text": [ "rocuronium/ sugammadex" ], "offsets": [ [ 276, 298 ] ], "normalized": [] }, { "id": "NCT02773173_exc_T18", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 300, 307 ] ], "normalized": [] }, { "id": "NCT02773173_exc_T19", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 311, 327 ] ], "normalized": [] }, { "id": "NCT02773173_exc_T20", "type": "Drug", "text": [ "rocuronium" ], "offsets": [ [ 331, 341 ] ], "normalized": [] }, { "id": "NCT02773173_exc_T21", "type": "Drug", "text": [ "sugammadex" ], "offsets": [ [ 344, 354 ] ], "normalized": [] }, { "id": "NCT02773173_exc_T22", "type": "Scope", "text": [ "rocuronium / sugammadex" ], "offsets": [ [ 331, 354 ] ], "normalized": [] }, { "id": "NCT02773173_exc_T23", "type": "Scope", "text": [ "allergy or hypersensitivity" ], "offsets": [ [ 300, 327 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02773173_exc_R1", "type": "Has_value", "arg1_id": "NCT02773173_exc_T9", "arg2_id": "NCT02773173_exc_T10", "normalized": [] }, { "id": "NCT02773173_exc_R3", "type": "Has_scope", "arg1_id": "NCT02773173_exc_T14", "arg2_id": "NCT02773173_exc_T17", "normalized": [] }, { "id": "NCT02773173_exc_R4", "type": "Has_scope", "arg1_id": "NCT02773173_exc_T23", "arg2_id": "NCT02773173_exc_T22", "normalized": [] } ]

[ { "id": "NCT02773173_inc_text", "type": "inclusion", "text": [ "Patients older than 18 years\nClassification of the American Society of Anesthesiologists (ASA I-III)\nNo cognitive deficits\nSigned informed consent prior to surgery\n" ], "offsets": [ [ 0, 164 ] ] } ]

[ { "id": "NCT02773173_inc_T1", "type": "Value", "text": [ "older than 18" ], "offsets": [ [ 9, 22 ] ], "normalized": [] }, { "id": "NCT02773173_inc_T2", "type": "Person", "text": [ "years" ], "offsets": [ [ 23, 28 ] ], "normalized": [] }, { "id": "NCT02773173_inc_T3", "type": "Measurement", "text": [ "Classification of the American Society of Anesthesiologists" ], "offsets": [ [ 29, 88 ] ], "normalized": [] }, { "id": "NCT02773173_inc_T4", "type": "Measurement", "text": [ "ASA" ], "offsets": [ [ 90, 93 ] ], "normalized": [] }, { "id": "NCT02773173_inc_T5", "type": "Value", "text": [ "I-III" ], "offsets": [ [ 94, 99 ] ], "normalized": [] }, { "id": "NCT02773173_inc_T6", "type": "Negation", "text": [ "No" ], "offsets": [ [ 101, 103 ] ], "normalized": [] }, { "id": "NCT02773173_inc_T7", "type": "Condition", "text": [ "cognitive deficits" ], "offsets": [ [ 104, 122 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02773173_inc_R1", "type": "Has_value", "arg1_id": "NCT02773173_inc_T2", "arg2_id": "NCT02773173_inc_T1", "normalized": [] }, { "id": "NCT02773173_inc_R2", "type": "Has_value", "arg1_id": "NCT02773173_inc_T4", "arg2_id": "NCT02773173_inc_T5", "normalized": [] }, { "id": "NCT02773173_inc_R3", "type": "Subsumes", "arg1_id": "NCT02773173_inc_T3", "arg2_id": "NCT02773173_inc_T4", "normalized": [] }, { "id": "NCT02773173_inc_R4", "type": "Has_negation", "arg1_id": "NCT02773173_inc_T7", "arg2_id": "NCT02773173_inc_T6", "normalized": [] } ]

[ { "id": "NCT02774317_exc_text", "type": "exclusion", "text": [ "Patients who are being prepared for surgery, or during or after surgery.\nPatients with congenital anomalies, chromosomal anomalies, or heart defects.\nPatients whose parents refuse to consent.\n" ], "offsets": [ [ 0, 192 ] ] } ]

[ { "id": "NCT02774317_exc_T1", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 36, 43 ] ], "normalized": [] }, { "id": "NCT02774317_exc_T2", "type": "Mood", "text": [ "being prepared for" ], "offsets": [ [ 17, 35 ] ], "normalized": [] }, { "id": "NCT02774317_exc_T3", "type": "Temporal", "text": [ "during", "surgery" ], "offsets": [ [ 48, 54 ], [ 64, 71 ] ], "normalized": [] }, { "id": "NCT02774317_exc_T4", "type": "Temporal", "text": [ "after surgery" ], "offsets": [ [ 58, 71 ] ], "normalized": [] }, { "id": "NCT02774317_exc_T5", "type": "Condition", "text": [ "congenital anomalies" ], "offsets": [ [ 87, 107 ] ], "normalized": [] }, { "id": "NCT02774317_exc_T6", "type": "Condition", "text": [ "chromosomal anomalies" ], "offsets": [ [ 109, 130 ] ], "normalized": [] }, { "id": "NCT02774317_exc_T7", "type": "Condition", "text": [ "heart defects" ], "offsets": [ [ 135, 148 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02774317_exc_R1", "type": "Has_mood", "arg1_id": "NCT02774317_exc_T1", "arg2_id": "NCT02774317_exc_T2", "normalized": [] } ]

[ { "id": "NCT02774317_inc_text", "type": "inclusion", "text": [ "Nonsurgical neonates and babies up to age 6 months with INR 1.5 or more who are deemed clinically to need plasma infusion.\n" ], "offsets": [ [ 0, 123 ] ] } ]

[ { "id": "NCT02774317_inc_T1", "type": "Person", "text": [ "neonates" ], "offsets": [ [ 12, 20 ] ], "normalized": [] }, { "id": "NCT02774317_inc_T2", "type": "Condition", "text": [ "Nonsurgical" ], "offsets": [ [ 0, 11 ] ], "normalized": [] }, { "id": "NCT02774317_inc_T3", "type": "Person", "text": [ "babies" ], "offsets": [ [ 25, 31 ] ], "normalized": [] }, { "id": "NCT02774317_inc_T4", "type": "Value", "text": [ "up to age 6 months" ], "offsets": [ [ 32, 50 ] ], "normalized": [] }, { "id": "NCT02774317_inc_T5", "type": "Person", "text": [ "age" ], "offsets": [ [ 38, 41 ] ], "normalized": [] }, { "id": "NCT02774317_inc_T6", "type": "Measurement", "text": [ "INR" ], "offsets": [ [ 56, 59 ] ], "normalized": [] }, { "id": "NCT02774317_inc_T7", "type": "Value", "text": [ "1.5 or more" ], "offsets": [ [ 60, 71 ] ], "normalized": [] }, { "id": "NCT02774317_inc_T8", "type": "Procedure", "text": [ "plasma infusion" ], "offsets": [ [ 106, 121 ] ], "normalized": [] }, { "id": "NCT02774317_inc_T9", "type": "Condition", "text": [ "need" ], "offsets": [ [ 101, 105 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02774317_inc_R1", "type": "Has_value", "arg1_id": "NCT02774317_inc_T5", "arg2_id": "NCT02774317_inc_T4", "normalized": [] }, { "id": "NCT02774317_inc_R2", "type": "Has_value", "arg1_id": "NCT02774317_inc_T6", "arg2_id": "NCT02774317_inc_T7", "normalized": [] }, { "id": "NCT02774317_inc_R3", "type": "AND", "arg1_id": "NCT02774317_inc_T9", "arg2_id": "NCT02774317_inc_T8", "normalized": [] }, { "id": "NCT02774317_inc_R4", "type": "AND", "arg1_id": "NCT02774317_inc_T1", "arg2_id": "NCT02774317_inc_T2", "normalized": [] }, { "id": "NCT02774317_inc_R5", "type": "AND", "arg1_id": "NCT02774317_inc_T3", "arg2_id": "NCT02774317_inc_T5", "normalized": [] } ]

[ { "id": "NCT02777424_exc_text", "type": "exclusion", "text": [ "Concomitant use with oral anticoagulant drugs\nAcquired deficiency of coagulation factors whose treatment is established\nHypersensitivity to a PCC\nHistory of thrombocytopenia induced by heparin\nDisseminated intravascular coagulation\nExtracranial active bleeding\nHypersensitivity to vitamin K\n" ], "offsets": [ [ 0, 291 ] ] } ]

[ { "id": "NCT02777424_exc_T1", "type": "Temporal", "text": [ "Concomitant" ], "offsets": [ [ 0, 11 ] ], "normalized": [] }, { "id": "NCT02777424_exc_T2", "type": "Drug", "text": [ "oral anticoagulant drugs" ], "offsets": [ [ 21, 45 ] ], "normalized": [] }, { "id": "NCT02777424_exc_T3", "type": "Condition", "text": [ "Acquired deficiency of coagulation factors" ], "offsets": [ [ 46, 88 ] ], "normalized": [] }, { "id": "NCT02777424_exc_T4", "type": "Qualifier", "text": [ "whose treatment is established" ], "offsets": [ [ 89, 119 ] ], "normalized": [] }, { "id": "NCT02777424_exc_T5", "type": "Condition", "text": [ "Hypersensitivity" ], "offsets": [ [ 120, 136 ] ], "normalized": [] }, { "id": "NCT02777424_exc_T6", "type": "Drug", "text": [ "PCC" ], "offsets": [ [ 142, 145 ] ], "normalized": [] }, { "id": "NCT02777424_exc_T7", "type": "Condition", "text": [ "thrombocytopenia" ], "offsets": [ [ 157, 173 ] ], "normalized": [] }, { "id": "NCT02777424_exc_T8", "type": "Drug", "text": [ "heparin" ], "offsets": [ [ 185, 192 ] ], "normalized": [] }, { "id": "NCT02777424_exc_T9", "type": "Condition", "text": [ "Disseminated intravascular coagulation" ], "offsets": [ [ 193, 231 ] ], "normalized": [] }, { "id": "NCT02777424_exc_T10", "type": "Condition", "text": [ "cranial acti", "ing\nHype" ], "offsets": [ [ 237, 249 ], [ 257, 265 ] ], "normalized": [] }, { "id": "NCT02777424_exc_T11", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 245, 251 ] ], "normalized": [] }, { "id": "NCT02777424_exc_T12", "type": "Condition", "text": [ "Hypersensitivity" ], "offsets": [ [ 261, 277 ] ], "normalized": [] }, { "id": "NCT02777424_exc_T13", "type": "Drug", "text": [ "vitamin K" ], "offsets": [ [ 281, 290 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02777424_exc_R1", "type": "Has_temporal", "arg1_id": "NCT02777424_exc_T2", "arg2_id": "NCT02777424_exc_T1", "normalized": [] }, { "id": "NCT02777424_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02777424_exc_T3", "arg2_id": "NCT02777424_exc_T4", "normalized": [] }, { "id": "NCT02777424_exc_R3", "type": "AND", "arg1_id": "NCT02777424_exc_T5", "arg2_id": "NCT02777424_exc_T6", "normalized": [] }, { "id": "NCT02777424_exc_R4", "type": "AND", "arg1_id": "NCT02777424_exc_T7", "arg2_id": "NCT02777424_exc_T8", "normalized": [] }, { "id": "NCT02777424_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02777424_exc_T10", "arg2_id": "NCT02777424_exc_T11", "normalized": [] }, { "id": "NCT02777424_exc_R6", "type": "AND", "arg1_id": "NCT02777424_exc_T12", "arg2_id": "NCT02777424_exc_T13", "normalized": [] } ]

[ { "id": "NCT02777424_inc_text", "type": "inclusion", "text": [ "Patient with spontaneous intracranial hemorrhage or traumatic intracranial hemorrhage or patient requiring neurological surgery\nCoagulation disorder defined by PT less than 60%\n" ], "offsets": [ [ 0, 177 ] ] } ]

[ { "id": "NCT02777424_inc_T1", "type": "Condition", "text": [ "spontaneous intracranial hemorrhage" ], "offsets": [ [ 13, 48 ] ], "normalized": [] }, { "id": "NCT02777424_inc_T2", "type": "Condition", "text": [ "traumatic intracranial hemorrhage" ], "offsets": [ [ 52, 85 ] ], "normalized": [] }, { "id": "NCT02777424_inc_T3", "type": "Mood", "text": [ "requiring" ], "offsets": [ [ 97, 106 ] ], "normalized": [] }, { "id": "NCT02777424_inc_T4", "type": "Procedure", "text": [ "neurological surgery" ], "offsets": [ [ 107, 127 ] ], "normalized": [] }, { "id": "NCT02777424_inc_T5", "type": "Condition", "text": [ "Coagulation disorder" ], "offsets": [ [ 128, 148 ] ], "normalized": [] }, { "id": "NCT02777424_inc_T6", "type": "Measurement", "text": [ "PT" ], "offsets": [ [ 160, 162 ] ], "normalized": [] }, { "id": "NCT02777424_inc_T7", "type": "Value", "text": [ "less than 60%" ], "offsets": [ [ 163, 176 ] ], "normalized": [] }, { "id": "NCT02777424_inc_T8", "type": "Scope", "text": [ "PT less than 60%" ], "offsets": [ [ 160, 176 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02777424_inc_R1", "type": "Has_mood", "arg1_id": "NCT02777424_inc_T4", "arg2_id": "NCT02777424_inc_T3", "normalized": [] }, { "id": "NCT02777424_inc_R2", "type": "Has_value", "arg1_id": "NCT02777424_inc_T6", "arg2_id": "NCT02777424_inc_T7", "normalized": [] }, { "id": "NCT02777424_inc_R3", "type": "Subsumes", "arg1_id": "NCT02777424_inc_T5", "arg2_id": "NCT02777424_inc_T8", "normalized": [] } ]

[ { "id": "NCT02777580_exc_text", "type": "exclusion", "text": [ "1. Expected performance of PCI < 60 minutes from diagnosis (qualifying ECG) or inability to arrive at the catheterisation laboratory within 3 hours\nPrevious CABG\nLeft bundle branch block or ventricular pacing\nPatients with cardiogenic shock - Killip Class 4\nPatients with a body weight < 55 kg (known or estimated)\nUncontrolled hypertension, defined as sustained blood pressure = 180/110 mm Hg (systolic BP = 180 mm Hg and/or diastolic BP = 110 mm Hg) prior to randomisation\nKnown prior stroke or TIA\nRecent administration of any i.v. or s.c. anticoagulation within 12 hours, including unfractionated heparin, enoxaparin, and/or bivalirudin or current use of oral anticoagulation (i.e. warfarin or a NOACs)\nActive bleeding or known bleeding disorder/diathesis\nKnown history of central nervous system damage (i.e. neoplasm, aneurysm, intracranial or spinal surgery) or recent trauma to the head or cranium (i.e. < 3 months)\nMajor surgery, biopsy of a parenchymal organ, or significant trauma within the past 2 months (this includes any trauma associated with the current myocardial infarction)\nClinical diagnosis associated with increased risk of bleeding including known active peptic ulceration and/or neoplasm with increased bleeding risk\nProlonged cardiopulmonary resuscitation (> 2 minutes) within the past 2 weeks\nKnown acute pericarditis and/or subacute bacterial endocarditis\nKnown acute pancreatitis or known severe hepatic dysfunction, including hepatic failure, cirrhosis, portal hypertension (oesophageal varices) and active hepatitis\nDementia\nKnown severe renal insufficiency\nPrevious enrolment in this study or treatment with an investigational drug or device under another study protocol in the past 7 days\nKnown allergic reactions to tenecteplase, clopidogrel, enoxaparin and aspirin\nInability to follow the protocol and comply with follow-up requirements or any other reason that the investigator feels would place the patient at increased risk if the investigational therapy is initiated.\n" ], "offsets": [ [ 0, 2006 ] ] } ]

[ { "id": "NCT02777580_exc_T1", "type": "Device", "text": [ "PCI" ], "offsets": [ [ 27, 30 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T2", "type": "Temporal", "text": [ "< 60 minutes from diagnosis" ], "offsets": [ [ 31, 58 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T3", "type": "Reference_point", "text": [ "diagnosis" ], "offsets": [ [ 49, 58 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T5", "type": "Procedure", "text": [ "CABG" ], "offsets": [ [ 157, 161 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T6", "type": "Condition", "text": [ "Left bundle branch block" ], "offsets": [ [ 162, 186 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T7", "type": "Condition", "text": [ "ventricular pacing" ], "offsets": [ [ 190, 208 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T8", "type": "Condition", "text": [ "cardiogenic shock" ], "offsets": [ [ 223, 240 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T9", "type": "Measurement", "text": [ "Killip Class" ], "offsets": [ [ 243, 255 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T10", "type": "Value", "text": [ "4" ], "offsets": [ [ 256, 257 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T11", "type": "Measurement", "text": [ "body weight" ], "offsets": [ [ 274, 285 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T12", "type": "Value", "text": [ "< 55 kg" ], "offsets": [ [ 286, 293 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T13", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 328, 340 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T14", "type": "Qualifier", "text": [ "Uncontrolled" ], "offsets": [ [ 315, 327 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T15", "type": "Measurement", "text": [ "blood pressure" ], "offsets": [ [ 363, 377 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T16", "type": "Value", "text": [ "= 180/110 mm Hg" ], "offsets": [ [ 378, 393 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T17", "type": "Measurement", "text": [ "systolic BP" ], "offsets": [ [ 395, 406 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T18", "type": "Value", "text": [ "= 180 mm Hg" ], "offsets": [ [ 407, 418 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T19", "type": "Measurement", "text": [ "diastolic BP" ], "offsets": [ [ 426, 438 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T20", "type": "Value", "text": [ "= 110 mm Hg" ], "offsets": [ [ 439, 450 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T21", "type": "Scope", "text": [ "systolic BP = 180 mm Hg and/or diastolic BP = 110 mm Hg" ], "offsets": [ [ 395, 450 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T22", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 487, 493 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T23", "type": "Condition", "text": [ "TIA" ], "offsets": [ [ 497, 500 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T24", "type": "Drug", "text": [ "anticoagulation" ], "offsets": [ [ 543, 558 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T25", "type": "Temporal", "text": [ "within 12 hours" ], "offsets": [ [ 559, 574 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T26", "type": "Drug", "text": [ "unfractionated heparin" ], "offsets": [ [ 586, 608 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T27", "type": "Drug", "text": [ "enoxaparin" ], "offsets": [ [ 610, 620 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T28", "type": "Drug", "text": [ "bivalirudin" ], "offsets": [ [ 629, 640 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T29", "type": "Drug", "text": [ "oral anticoagulation" ], "offsets": [ [ 659, 679 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T30", "type": "Drug", "text": [ "warfarin" ], "offsets": [ [ 686, 694 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T31", "type": "Drug", "text": [ "NOACs" ], "offsets": [ [ 700, 705 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T32", "type": "Scope", "text": [ "unfractionated heparin, enoxaparin, and/or bivalirudin or current use of oral anticoagulation (i.e. warfarin or a NOACs)" ], "offsets": [ [ 586, 706 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T33", "type": "Scope", "text": [ "warfarin or a NOACs" ], "offsets": [ [ 686, 705 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T34", "type": "Condition", "text": [ "Active bleeding" ], "offsets": [ [ 707, 722 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T35", "type": "Condition", "text": [ "bleeding disorder" ], "offsets": [ [ 732, 749 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T36", "type": "Condition", "text": [ "diathesis" ], "offsets": [ [ 750, 759 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T37", "type": "Condition", "text": [ "central nervous system damage" ], "offsets": [ [ 777, 806 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T38", "type": "Condition", "text": [ "neoplasm" ], "offsets": [ [ 813, 821 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T39", "type": "Condition", "text": [ "aneurysm" ], "offsets": [ [ 823, 831 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T40", "type": "Procedure", "text": [ "ial or spina", "or rece" ], "offsets": [ [ 842, 854 ], [ 865, 872 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T41", "type": "Procedure", "text": [ "spinal surgery" ], "offsets": [ [ 849, 863 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T42", "type": "Scope", "text": [ "neoplasm, aneurysm, intracranial or spinal surgery" ], "offsets": [ [ 813, 863 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T43", "type": "Condition", "text": [ "trauma" ], "offsets": [ [ 875, 881 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T44", "type": "Qualifier", "text": [ "head" ], "offsets": [ [ 889, 893 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T45", "type": "Qualifier", "text": [ "cranium" ], "offsets": [ [ 897, 904 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T46", "type": "Temporal", "text": [ "< 3 months" ], "offsets": [ [ 911, 921 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T47", "type": "Scope", "text": [ "head or cranium" ], "offsets": [ [ 889, 904 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T48", "type": "Procedure", "text": [ "Major surgery" ], "offsets": [ [ 923, 936 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T49", "type": "Procedure", "text": [ "biopsy" ], "offsets": [ [ 938, 944 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T50", "type": "Qualifier", "text": [ "parenchymal organ" ], "offsets": [ [ 950, 967 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T51", "type": "Condition", "text": [ "trauma" ], "offsets": [ [ 984, 990 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T52", "type": "Qualifier", "text": [ "significant" ], "offsets": [ [ 972, 983 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T53", "type": "Temporal", "text": [ "past 2 months" ], "offsets": [ [ 1002, 1015 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T54", "type": "Scope", "text": [ "Major surgery, biopsy of a parenchymal organ, or significant trauma" ], "offsets": [ [ 923, 990 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T55", "type": "Condition", "text": [ "myocardial infarction" ], "offsets": [ [ 1070, 1091 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T56", "type": "Observation", "text": [ "risk of bleeding" ], "offsets": [ [ 1138, 1154 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T57", "type": "Qualifier", "text": [ "increased" ], "offsets": [ [ 1128, 1137 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T58", "type": "Condition", "text": [ "peptic ulceration" ], "offsets": [ [ 1178, 1195 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T59", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 1171, 1177 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T60", "type": "Condition", "text": [ "neoplasm" ], "offsets": [ [ 1203, 1211 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T61", "type": "Scope", "text": [ "active peptic ulceration and/or neoplasm" ], "offsets": [ [ 1171, 1211 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T62", "type": "Condition", "text": [ "cardiopulmonary resuscitation" ], "offsets": [ [ 1251, 1280 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T63", "type": "Qualifier", "text": [ "Prolonged" ], "offsets": [ [ 1241, 1250 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T64", "type": "Temporal", "text": [ "past 2 weeks" ], "offsets": [ [ 1306, 1318 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T65", "type": "Condition", "text": [ "acute pericarditis" ], "offsets": [ [ 1325, 1343 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T66", "type": "Condition", "text": [ "subacute bacterial endocarditis" ], "offsets": [ [ 1351, 1382 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T67", "type": "Condition", "text": [ "acute pancreatitis" ], "offsets": [ [ 1389, 1407 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T68", "type": "Condition", "text": [ "hepatic dysfunction" ], "offsets": [ [ 1424, 1443 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T69", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 1417, 1423 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T70", "type": "Condition", "text": [ "hepatic failure" ], "offsets": [ [ 1455, 1470 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T71", "type": "Condition", "text": [ "cirrhosis" ], "offsets": [ [ 1472, 1481 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T72", "type": "Condition", "text": [ "portal hypertension" ], "offsets": [ [ 1483, 1502 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T73", "type": "Condition", "text": [ "active hepatitis" ], "offsets": [ [ 1529, 1545 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T74", "type": "Condition", "text": [ "oesophageal varices" ], "offsets": [ [ 1504, 1523 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T75", "type": "Scope", "text": [ "hepatic failure, cirrhosis, portal hypertension (oesophageal varices) and active hepatitis" ], "offsets": [ [ 1455, 1545 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T76", "type": "Condition", "text": [ "Dementia" ], "offsets": [ [ 1546, 1554 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T77", "type": "Condition", "text": [ "renal insufficiency" ], "offsets": [ [ 1568, 1587 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T78", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 1561, 1567 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T80", "type": "Condition", "text": [ "allergic reactions" ], "offsets": [ [ 1727, 1745 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T81", "type": "Drug", "text": [ "tenecteplase" ], "offsets": [ [ 1749, 1761 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T82", "type": "Drug", "text": [ "clopidogrel" ], "offsets": [ [ 1763, 1774 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T83", "type": "Drug", "text": [ "enoxaparin" ], "offsets": [ [ 1776, 1786 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T84", "type": "Drug", "text": [ "aspirin" ], "offsets": [ [ 1791, 1798 ] ], "normalized": [] }, { "id": "NCT02777580_exc_T85", "type": "Scope", "text": [ "tenecteplase, clopidogrel, enoxaparin and aspirin" ], "offsets": [ [ 1749, 1798 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02777580_exc_R1", "type": "Has_index", "arg1_id": "NCT02777580_exc_T2", "arg2_id": "NCT02777580_exc_T3", "normalized": [] }, { "id": "NCT02777580_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02777580_exc_T1", "arg2_id": "NCT02777580_exc_T2", "normalized": [] }, { "id": "NCT02777580_exc_R3", "type": "Has_value", "arg1_id": "NCT02777580_exc_T9", "arg2_id": "NCT02777580_exc_T10", "normalized": [] }, { "id": "NCT02777580_exc_R4", "type": "AND", "arg1_id": "NCT02777580_exc_T8", "arg2_id": "NCT02777580_exc_T9", "normalized": [] }, { "id": "NCT02777580_exc_R5", "type": "Has_value", "arg1_id": "NCT02777580_exc_T11", "arg2_id": "NCT02777580_exc_T12", "normalized": [] }, { "id": "NCT02777580_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02777580_exc_T13", "arg2_id": "NCT02777580_exc_T14", "normalized": [] }, { "id": "NCT02777580_exc_R7", "type": "Has_value", "arg1_id": "NCT02777580_exc_T17", "arg2_id": "NCT02777580_exc_T18", "normalized": [] }, { "id": "NCT02777580_exc_R8", "type": "Has_value", "arg1_id": "NCT02777580_exc_T19", "arg2_id": "NCT02777580_exc_T20", "normalized": [] }, { "id": "NCT02777580_exc_R9", "type": "Has_value", "arg1_id": "NCT02777580_exc_T15", "arg2_id": "NCT02777580_exc_T16", "normalized": [] }, { "id": "NCT02777580_exc_R10", "type": "Subsumes", "arg1_id": "NCT02777580_exc_T15", "arg2_id": "NCT02777580_exc_T21", "normalized": [] }, { "id": "NCT02777580_exc_R11", "type": "AND", "arg1_id": "NCT02777580_exc_T13", "arg2_id": "NCT02777580_exc_T15", "normalized": [] }, { "id": "NCT02777580_exc_R12", "type": "Has_temporal", "arg1_id": "NCT02777580_exc_T24", "arg2_id": "NCT02777580_exc_T25", "normalized": [] }, { "id": "NCT02777580_exc_R13", "type": "Subsumes", "arg1_id": "NCT02777580_exc_T29", "arg2_id": "NCT02777580_exc_T33", "normalized": [] }, { "id": "NCT02777580_exc_R14", "type": "Subsumes", "arg1_id": "NCT02777580_exc_T24", "arg2_id": "NCT02777580_exc_T32", "normalized": [] }, { "id": "NCT02777580_exc_R15", "type": "Subsumes", "arg1_id": "NCT02777580_exc_T37", "arg2_id": "NCT02777580_exc_T42", "normalized": [] }, { "id": "NCT02777580_exc_R16", "type": "Has_scope", "arg1_id": "NCT02777580_exc_T43", "arg2_id": "NCT02777580_exc_T47", "normalized": [] }, { "id": "NCT02777580_exc_R17", "type": "Has_temporal", "arg1_id": "NCT02777580_exc_T43", "arg2_id": "NCT02777580_exc_T46", "normalized": [] }, { "id": "NCT02777580_exc_R18", "type": "Has_qualifier", "arg1_id": "NCT02777580_exc_T51", "arg2_id": "NCT02777580_exc_T52", "normalized": [] }, { "id": "NCT02777580_exc_R19", "type": "Has_qualifier", "arg1_id": "NCT02777580_exc_T49", "arg2_id": "NCT02777580_exc_T50", "normalized": [] }, { "id": "NCT02777580_exc_R20", "type": "Has_temporal", "arg1_id": "NCT02777580_exc_T54", "arg2_id": "NCT02777580_exc_T53", "normalized": [] }, { "id": "NCT02777580_exc_R21", "type": "Subsumes", "arg1_id": "NCT02777580_exc_T51", "arg2_id": "NCT02777580_exc_T55", "normalized": [] }, { "id": "NCT02777580_exc_R22", "type": "Has_qualifier", "arg1_id": "NCT02777580_exc_T56", "arg2_id": "NCT02777580_exc_T57", "normalized": [] }, { "id": "NCT02777580_exc_R23", "type": "Has_qualifier", "arg1_id": "NCT02777580_exc_T58", "arg2_id": "NCT02777580_exc_T59", "normalized": [] }, { "id": "NCT02777580_exc_R24", "type": "Subsumes", "arg1_id": "NCT02777580_exc_T56", "arg2_id": "NCT02777580_exc_T61", "normalized": [] }, { "id": "NCT02777580_exc_R25", "type": "Has_qualifier", "arg1_id": "NCT02777580_exc_T62", "arg2_id": "NCT02777580_exc_T63", "normalized": [] }, { "id": "NCT02777580_exc_R26", "type": "Has_temporal", "arg1_id": "NCT02777580_exc_T62", "arg2_id": "NCT02777580_exc_T64", "normalized": [] }, { "id": "NCT02777580_exc_R27", "type": "Has_qualifier", "arg1_id": "NCT02777580_exc_T68", "arg2_id": "NCT02777580_exc_T69", "normalized": [] }, { "id": "NCT02777580_exc_R28", "type": "Subsumes", "arg1_id": "NCT02777580_exc_T72", "arg2_id": "NCT02777580_exc_T74", "normalized": [] }, { "id": "NCT02777580_exc_R29", "type": "Subsumes", "arg1_id": "NCT02777580_exc_T68", "arg2_id": "NCT02777580_exc_T75", "normalized": [] }, { "id": "NCT02777580_exc_R30", "type": "Has_qualifier", "arg1_id": "NCT02777580_exc_T77", "arg2_id": "NCT02777580_exc_T78", "normalized": [] }, { "id": "NCT02777580_exc_R31", "type": "Has_scope", "arg1_id": "NCT02777580_exc_T80", "arg2_id": "NCT02777580_exc_T85", "normalized": [] } ]

[ { "id": "NCT02777580_inc_text", "type": "inclusion", "text": [ "Age equal or greater than 70 years\nOnset of symptoms < 3 hours prior to randomisation\n= 2 mm ST-elevation across 2 contiguous precordial leads (V1-V6) or leads I and aVL for a minimum combined total of = 4 mm ST-elevation or\n= 2 mm ST-elevation in 2 contiguous inferior leads (II, III, aVF) for a minimum combined total of = 4 mm ST-elevation\nInformed consent received\n" ], "offsets": [ [ 0, 369 ] ] } ]

[ { "id": "NCT02777580_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02777580_inc_T2", "type": "Value", "text": [ "equal or greater than 70 years" ], "offsets": [ [ 4, 34 ] ], "normalized": [] }, { "id": "NCT02777580_inc_T3", "type": "Observation", "text": [ "Onset of symptoms" ], "offsets": [ [ 35, 52 ] ], "normalized": [] }, { "id": "NCT02777580_inc_T4", "type": "Temporal", "text": [ "< 3 hours prior to randomisation" ], "offsets": [ [ 53, 85 ] ], "normalized": [] }, { "id": "NCT02777580_inc_T5", "type": "Reference_point", "text": [ "randomisation" ], "offsets": [ [ 72, 85 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02777580_inc_R1", "type": "Has_value", "arg1_id": "NCT02777580_inc_T1", "arg2_id": "NCT02777580_inc_T2", "normalized": [] }, { "id": "NCT02777580_inc_R2", "type": "Has_index", "arg1_id": "NCT02777580_inc_T4", "arg2_id": "NCT02777580_inc_T5", "normalized": [] }, { "id": "NCT02777580_inc_R3", "type": "Has_temporal", "arg1_id": "NCT02777580_inc_T3", "arg2_id": "NCT02777580_inc_T4", "normalized": [] } ]

[ { "id": "NCT02779374_exc_text", "type": "exclusion", "text": [ "Abnormal karyotype \nPrevious pelvic or abdominal radiotherapy \nPrevious surgical management of ovarian pathology \nChronic disease: renal, liver, cardiac, malignancy \n \n" ], "offsets": [ [ 0, 177 ] ] } ]

[ { "id": "NCT02779374_exc_T1", "type": "Condition", "text": [ "Abnormal karyotype" ], "offsets": [ [ 0, 18 ] ], "normalized": [] }, { "id": "NCT02779374_exc_T2", "type": "Procedure", "text": [ "pelvic", "radiotherapy" ], "offsets": [ [ 29, 35 ], [ 49, 61 ] ], "normalized": [] }, { "id": "NCT02779374_exc_T3", "type": "Procedure", "text": [ "abdominal radiotherapy" ], "offsets": [ [ 39, 61 ] ], "normalized": [] }, { "id": "NCT02779374_exc_T4", "type": "Temporal", "text": [ "Previous" ], "offsets": [ [ 20, 28 ] ], "normalized": [] }, { "id": "NCT02779374_exc_T5", "type": "Scope", "text": [ "pelvic or abdominal radiotherapy" ], "offsets": [ [ 29, 61 ] ], "normalized": [] }, { "id": "NCT02779374_exc_T6", "type": "Procedure", "text": [ "surgical management" ], "offsets": [ [ 72, 91 ] ], "normalized": [] }, { "id": "NCT02779374_exc_T7", "type": "Condition", "text": [ "ovarian pathology" ], "offsets": [ [ 95, 112 ] ], "normalized": [] }, { "id": "NCT02779374_exc_T8", "type": "Temporal", "text": [ "Previous" ], "offsets": [ [ 63, 71 ] ], "normalized": [] }, { "id": "NCT02779374_exc_T9", "type": "Condition", "text": [ "renal", "malignancy" ], "offsets": [ [ 131, 136 ], [ 154, 164 ] ], "normalized": [] }, { "id": "NCT02779374_exc_T10", "type": "Condition", "text": [ "cardiac", "malignancy" ], "offsets": [ [ 145, 152 ], [ 154, 164 ] ], "normalized": [] }, { "id": "NCT02779374_exc_T11", "type": "Condition", "text": [ "liver", "malignancy" ], "offsets": [ [ 138, 143 ], [ 154, 164 ] ], "normalized": [] }, { "id": "NCT02779374_exc_T12", "type": "Condition", "text": [ "Chronic disease" ], "offsets": [ [ 114, 129 ] ], "normalized": [] }, { "id": "NCT02779374_exc_T14", "type": "Scope", "text": [ "renal, liver, cardiac, malignancy" ], "offsets": [ [ 131, 164 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02779374_exc_R1", "type": "Has_temporal", "arg1_id": "NCT02779374_exc_T5", "arg2_id": "NCT02779374_exc_T4", "normalized": [] }, { "id": "NCT02779374_exc_R2", "type": "AND", "arg1_id": "NCT02779374_exc_T6", "arg2_id": "NCT02779374_exc_T7", "normalized": [] }, { "id": "NCT02779374_exc_R3", "type": "Has_temporal", "arg1_id": "NCT02779374_exc_T6", "arg2_id": "NCT02779374_exc_T8", "normalized": [] }, { "id": "NCT02779374_exc_R4", "type": "Subsumes", "arg1_id": "NCT02779374_exc_T12", "arg2_id": "NCT02779374_exc_T14", "normalized": [] } ]

[ { "id": "NCT02779374_inc_text", "type": "inclusion", "text": [ "Women with POI: For the purpose of the research women is considered to have POI if she is aged less than 40 years and has amenorrhea of at least 4 month with FSH level above 25 IU/L (repeated twice >4 weeks apart). \n" ], "offsets": [ [ 0, 216 ] ] } ]

[ { "id": "NCT02779374_inc_T1", "type": "Person", "text": [ "Women" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT02779374_inc_T2", "type": "Condition", "text": [ "POI" ], "offsets": [ [ 11, 14 ] ], "normalized": [] }, { "id": "NCT02779374_inc_T3", "type": "Person", "text": [ "aged" ], "offsets": [ [ 90, 94 ] ], "normalized": [] }, { "id": "NCT02779374_inc_T4", "type": "Value", "text": [ "less than 40 years" ], "offsets": [ [ 95, 113 ] ], "normalized": [] }, { "id": "NCT02779374_inc_T5", "type": "Condition", "text": [ "amenorrhea" ], "offsets": [ [ 122, 132 ] ], "normalized": [] }, { "id": "NCT02779374_inc_T6", "type": "Temporal", "text": [ "at least 4 month" ], "offsets": [ [ 136, 152 ] ], "normalized": [] }, { "id": "NCT02779374_inc_T7", "type": "Measurement", "text": [ "FSH level" ], "offsets": [ [ 158, 167 ] ], "normalized": [] }, { "id": "NCT02779374_inc_T8", "type": "Value", "text": [ "above 25 IU/L" ], "offsets": [ [ 168, 181 ] ], "normalized": [] }, { "id": "NCT02779374_inc_T9", "type": "Multiplier", "text": [ "repeated twice" ], "offsets": [ [ 183, 197 ] ], "normalized": [] }, { "id": "NCT02779374_inc_T10", "type": "Temporal", "text": [ ">4 weeks apart" ], "offsets": [ [ 198, 212 ] ], "normalized": [] }, { "id": "NCT02779374_inc_T11", "type": "Scope", "text": [ "aged less than 40 years and has amenorrhea of at least 4 month with FSH level above 25 IU/L (repeated twice >4 weeks apart)" ], "offsets": [ [ 90, 213 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02779374_inc_R1", "type": "AND", "arg1_id": "NCT02779374_inc_T1", "arg2_id": "NCT02779374_inc_T2", "normalized": [] }, { "id": "NCT02779374_inc_R2", "type": "Has_value", "arg1_id": "NCT02779374_inc_T3", "arg2_id": "NCT02779374_inc_T4", "normalized": [] }, { "id": "NCT02779374_inc_R3", "type": "Has_temporal", "arg1_id": "NCT02779374_inc_T9", "arg2_id": "NCT02779374_inc_T10", "normalized": [] }, { "id": "NCT02779374_inc_R4", "type": "Has_value", "arg1_id": "NCT02779374_inc_T7", "arg2_id": "NCT02779374_inc_T8", "normalized": [] }, { "id": "NCT02779374_inc_R5", "type": "Has_multiplier", "arg1_id": "NCT02779374_inc_T7", "arg2_id": "NCT02779374_inc_T9", "normalized": [] }, { "id": "NCT02779374_inc_R6", "type": "Has_temporal", "arg1_id": "NCT02779374_inc_T5", "arg2_id": "NCT02779374_inc_T6", "normalized": [] }, { "id": "NCT02779374_inc_R7", "type": "AND", "arg1_id": "NCT02779374_inc_T5", "arg2_id": "NCT02779374_inc_T7", "normalized": [] }, { "id": "NCT02779374_inc_R8", "type": "Has_scope", "arg1_id": "NCT02779374_inc_T2", "arg2_id": "NCT02779374_inc_T11", "normalized": [] } ]

[ { "id": "NCT02780427_exc_text", "type": "exclusion", "text": [ "Known allergy or hypersensitive reaction to dexmedetomidine\nOrgan dysfunction, and significant developmental delays or behavior problems\nCardiac arrhythmia\nKnown. acyanotic congenital heart disease or children after cardiac interventional procedures for follow-up examination.\n" ], "offsets": [ [ 0, 277 ] ] } ]

[ { "id": "NCT02780427_exc_T1", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 6, 13 ] ], "normalized": [] }, { "id": "NCT02780427_exc_T2", "type": "Condition", "text": [ "hypersensitive" ], "offsets": [ [ 17, 31 ] ], "normalized": [] }, { "id": "NCT02780427_exc_T3", "type": "Drug", "text": [ "dexmedetomidine" ], "offsets": [ [ 44, 59 ] ], "normalized": [] }, { "id": "NCT02780427_exc_T4", "type": "Scope", "text": [ "allergy or hypersensitive" ], "offsets": [ [ 6, 31 ] ], "normalized": [] }, { "id": "NCT02780427_exc_T5", "type": "Condition", "text": [ "Organ dysfunction" ], "offsets": [ [ 60, 77 ] ], "normalized": [] }, { "id": "NCT02780427_exc_T6", "type": "Condition", "text": [ "developmental delays" ], "offsets": [ [ 95, 115 ] ], "normalized": [] }, { "id": "NCT02780427_exc_T7", "type": "Qualifier", "text": [ "significant" ], "offsets": [ [ 83, 94 ] ], "normalized": [] }, { "id": "NCT02780427_exc_T8", "type": "Condition", "text": [ "behavior problems" ], "offsets": [ [ 119, 136 ] ], "normalized": [] }, { "id": "NCT02780427_exc_T9", "type": "Condition", "text": [ "Cardiac arrhythmia" ], "offsets": [ [ 137, 155 ] ], "normalized": [] }, { "id": "NCT02780427_exc_T10", "type": "Condition", "text": [ "acyanotic congenital heart disease" ], "offsets": [ [ 163, 197 ] ], "normalized": [] }, { "id": "NCT02780427_exc_T11", "type": "Person", "text": [ "children" ], "offsets": [ [ 201, 209 ] ], "normalized": [] }, { "id": "NCT02780427_exc_T12", "type": "Temporal", "text": [ "after cardiac interventional procedures" ], "offsets": [ [ 210, 249 ] ], "normalized": [] }, { "id": "NCT02780427_exc_T13", "type": "Reference_point", "text": [ "cardiac interventional procedures" ], "offsets": [ [ 216, 249 ] ], "normalized": [] }, { "id": "NCT02780427_exc_T14", "type": "Procedure", "text": [ "cardiac interventional procedures" ], "offsets": [ [ 216, 249 ] ], "normalized": [] }, { "id": "NCT02780427_exc_T15", "type": "Procedure", "text": [ "follow-up examination" ], "offsets": [ [ 254, 275 ] ], "normalized": [] }, { "id": "NCT02780427_exc_T16", "type": "Qualifier", "text": [ "for follow-up examination" ], "offsets": [ [ 250, 275 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02780427_exc_R1", "type": "AND", "arg1_id": "NCT02780427_exc_T4", "arg2_id": "NCT02780427_exc_T3", "normalized": [] }, { "id": "NCT02780427_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02780427_exc_T6", "arg2_id": "NCT02780427_exc_T7", "normalized": [] }, { "id": "NCT02780427_exc_R4", "type": "AND", "arg1_id": "NCT02780427_exc_T12", "arg2_id": "NCT02780427_exc_T14", "normalized": [] }, { "id": "NCT02780427_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02780427_exc_T14", "arg2_id": "NCT02780427_exc_T16", "normalized": [] } ]

[ { "id": "NCT02780427_inc_text", "type": "inclusion", "text": [ "Children, aged between one and 24 months. classified as (American Society of Anesthesiologists) ASA physical status I or II, undergoing TEE were enrolled in the study.\n" ], "offsets": [ [ 0, 168 ] ] } ]

[ { "id": "NCT02780427_inc_T1", "type": "Person", "text": [ "Children" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT02780427_inc_T2", "type": "Person", "text": [ "aged" ], "offsets": [ [ 10, 14 ] ], "normalized": [] }, { "id": "NCT02780427_inc_T3", "type": "Value", "text": [ "between one and 24 months" ], "offsets": [ [ 15, 40 ] ], "normalized": [] }, { "id": "NCT02780427_inc_T4", "type": "Measurement", "text": [ "American Society of Anesthesiologists" ], "offsets": [ [ 57, 94 ] ], "normalized": [] }, { "id": "NCT02780427_inc_T5", "type": "Measurement", "text": [ "ASA physical status" ], "offsets": [ [ 96, 115 ] ], "normalized": [] }, { "id": "NCT02780427_inc_T6", "type": "Value", "text": [ "I or II" ], "offsets": [ [ 116, 123 ] ], "normalized": [] }, { "id": "NCT02780427_inc_T7", "type": "Procedure", "text": [ "TEE" ], "offsets": [ [ 136, 139 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02780427_inc_R1", "type": "Has_value", "arg1_id": "NCT02780427_inc_T2", "arg2_id": "NCT02780427_inc_T3", "normalized": [] }, { "id": "NCT02780427_inc_R2", "type": "Subsumes", "arg1_id": "NCT02780427_inc_T5", "arg2_id": "NCT02780427_inc_T4", "normalized": [] }, { "id": "NCT02780427_inc_R3", "type": "Has_value", "arg1_id": "NCT02780427_inc_T5", "arg2_id": "NCT02780427_inc_T6", "normalized": [] } ]

[ { "id": "NCT02781610_exc_text", "type": "exclusion", "text": [ "Previous randomization in this study\nTreatment with IV antibiotics in the 6 weeks prior to Visit 1\nAdmission to the intensive care unit for current pulmonary exacerbation in the two weeks prior to Visit 2, unless admission was due to a desensitization protocol\nPneumothorax in the two weeks prior to Visit 2\nPrimary diagnosis for current hospitalization is unrelated to worsening lower respiratory symptoms (e.g., pulmonary clean out, distal intestinal obstruction syndrome (DIOS), sinusitis)\nMassive hemoptysis defined as > 250 cc in a 24 hour period or 100 cc/day over 4 consecutive days occurring in the two weeks prior to Visit 2\nCurrent pulmonary exacerbation thought to be due to allergic bronchopulmonary aspergillosis (ABPA)\nAt Visit 1, receiving ongoing treatment with a duration of more than 2 weeks with prednisone equivalent to >10mg/day\nHistory of solid organ transplantation\nReceiving antimicrobial therapy to treat non-tuberculous mycobacterium (e.g., M. abscessus, M. avium complex) in the two weeks prior to Visit 2\n" ], "offsets": [ [ 0, 1033 ] ] } ]

[ { "id": "NCT02781610_exc_T2", "type": "Drug", "text": [ "IV antibiotics" ], "offsets": [ [ 52, 66 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T3", "type": "Temporal", "text": [ "in the 6 weeks prior to Visit 1" ], "offsets": [ [ 67, 98 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T4", "type": "Reference_point", "text": [ "Visit 1" ], "offsets": [ [ 91, 98 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T5", "type": "Observation", "text": [ "Admission to the intensive care unit" ], "offsets": [ [ 99, 135 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T6", "type": "Visit", "text": [ "intensive care unit" ], "offsets": [ [ 116, 135 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T7", "type": "Condition", "text": [ "pulmonary exacerbation" ], "offsets": [ [ 148, 170 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T8", "type": "Temporal", "text": [ "in the two weeks prior to Visit 2" ], "offsets": [ [ 171, 204 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T9", "type": "Reference_point", "text": [ "Visit 2" ], "offsets": [ [ 197, 204 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T11", "type": "Procedure", "text": [ "desensitization protocol" ], "offsets": [ [ 236, 260 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T10", "type": "Negation", "text": [ "unless" ], "offsets": [ [ 206, 212 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T12", "type": "Condition", "text": [ "Pneumothorax" ], "offsets": [ [ 261, 273 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T13", "type": "Temporal", "text": [ "in the two weeks prior to Visit 2" ], "offsets": [ [ 274, 307 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T14", "type": "Reference_point", "text": [ "Visit 2" ], "offsets": [ [ 300, 307 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T15", "type": "Condition", "text": [ "Primary diagnosis" ], "offsets": [ [ 308, 325 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T16", "type": "Observation", "text": [ "current hospitalization" ], "offsets": [ [ 330, 353 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T17", "type": "Negation", "text": [ "unrelated" ], "offsets": [ [ 357, 366 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T18", "type": "Condition", "text": [ "lower respiratory symptoms" ], "offsets": [ [ 380, 406 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T19", "type": "Qualifier", "text": [ "worsening" ], "offsets": [ [ 370, 379 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T20", "type": "Condition", "text": [ "pulmonary clean out" ], "offsets": [ [ 414, 433 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T21", "type": "Condition", "text": [ "distal intestinal obstruction syndrome" ], "offsets": [ [ 435, 473 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T22", "type": "Condition", "text": [ "DIOS" ], "offsets": [ [ 475, 479 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T23", "type": "Condition", "text": [ "sinusitis" ], "offsets": [ [ 482, 491 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T24", "type": "Scope", "text": [ "(e.g., pulmonary clean out, distal intestinal obstruction syndrome (DIOS), sinusitis)" ], "offsets": [ [ 407, 492 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T25", "type": "Condition", "text": [ "hemoptysis" ], "offsets": [ [ 501, 511 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T26", "type": "Qualifier", "text": [ "Massive" ], "offsets": [ [ 493, 500 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T27", "type": "Multiplier", "text": [ "> 250 cc" ], "offsets": [ [ 523, 531 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T28", "type": "Temporal", "text": [ "in a 24 hour period" ], "offsets": [ [ 532, 551 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T29", "type": "Multiplier", "text": [ "100 cc/day" ], "offsets": [ [ 555, 565 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T30", "type": "Temporal", "text": [ "over 4 consecutive days" ], "offsets": [ [ 566, 589 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T31", "type": "Temporal", "text": [ "in the two weeks prior to Visit 2" ], "offsets": [ [ 600, 633 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T32", "type": "Reference_point", "text": [ "Visit 2" ], "offsets": [ [ 626, 633 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T33", "type": "Scope", "text": [ "> 250 cc in a 24 hour period or 100 cc/day over 4 consecutive days" ], "offsets": [ [ 523, 589 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T34", "type": "Condition", "text": [ "pulmonary exacerbation" ], "offsets": [ [ 642, 664 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T35", "type": "Condition", "text": [ "allergic bronchopulmonary aspergillosis" ], "offsets": [ [ 686, 725 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T36", "type": "Condition", "text": [ "ABPA" ], "offsets": [ [ 727, 731 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T38", "type": "Temporal", "text": [ "t 1, recei", "an 2 weeks with p" ], "offsets": [ [ 740, 750 ], [ 799, 816 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T37", "type": "Drug", "text": [ "prednisone" ], "offsets": [ [ 815, 825 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T39", "type": "Multiplier", "text": [ ">10mg/day" ], "offsets": [ [ 840, 849 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T40", "type": "Reference_point", "text": [ "Visit 1" ], "offsets": [ [ 736, 743 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T41", "type": "Condition", "text": [ "solid organ transplantation" ], "offsets": [ [ 861, 888 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T42", "type": "Drug", "text": [ "antimicrobial therapy" ], "offsets": [ [ 899, 920 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T43", "type": "Qualifier", "text": [ "non-tuberculous mycobacterium" ], "offsets": [ [ 930, 959 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T44", "type": "Qualifier", "text": [ "M. abscessus" ], "offsets": [ [ 967, 979 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T45", "type": "Qualifier", "text": [ "M. avium complex" ], "offsets": [ [ 981, 997 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T46", "type": "Temporal", "text": [ "in the two weeks prior to Visit 2" ], "offsets": [ [ 999, 1032 ] ], "normalized": [] }, { "id": "NCT02781610_exc_T47", "type": "Reference_point", "text": [ "Visit 2" ], "offsets": [ [ 1025, 1032 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02781610_exc_R1", "type": "Has_index", "arg1_id": "NCT02781610_exc_T3", "arg2_id": "NCT02781610_exc_T4", "normalized": [] }, { "id": "NCT02781610_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02781610_exc_T2", "arg2_id": "NCT02781610_exc_T3", "normalized": [] }, { "id": "NCT02781610_exc_R4", "type": "AND", "arg1_id": "NCT02781610_exc_T5", "arg2_id": "NCT02781610_exc_T7", "normalized": [] }, { "id": "NCT02781610_exc_R5", "type": "Has_index", "arg1_id": "NCT02781610_exc_T8", "arg2_id": "NCT02781610_exc_T9", "normalized": [] }, { "id": "NCT02781610_exc_R6", "type": "Subsumes", "arg1_id": "NCT02781610_exc_T7", "arg2_id": "NCT02781610_exc_T8", "normalized": [] }, { "id": "NCT02781610_exc_R7", "type": "Has_negation", "arg1_id": "NCT02781610_exc_T11", "arg2_id": "NCT02781610_exc_T10", "normalized": [] }, { "id": "NCT02781610_exc_R8", "type": "Has_index", "arg1_id": "NCT02781610_exc_T13", "arg2_id": "NCT02781610_exc_T14", "normalized": [] }, { "id": "NCT02781610_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT02781610_exc_T18", "arg2_id": "NCT02781610_exc_T19", "normalized": [] }, { "id": "NCT02781610_exc_R11", "type": "Subsumes", "arg1_id": "NCT02781610_exc_T21", "arg2_id": "NCT02781610_exc_T22", "normalized": [] }, { "id": "NCT02781610_exc_R12", "type": "Subsumes", "arg1_id": "NCT02781610_exc_T18", "arg2_id": "NCT02781610_exc_T24", "normalized": [] }, { "id": "NCT02781610_exc_R13", "type": "Has_index", "arg1_id": "NCT02781610_exc_T31", "arg2_id": "NCT02781610_exc_T32", "normalized": [] }, { "id": "NCT02781610_exc_R14", "type": "Has_qualifier", "arg1_id": "NCT02781610_exc_T25", "arg2_id": "NCT02781610_exc_T26", "normalized": [] }, { "id": "NCT02781610_exc_R15", "type": "Has_scope", "arg1_id": "NCT02781610_exc_T25", "arg2_id": "NCT02781610_exc_T33", "normalized": [] }, { "id": "NCT02781610_exc_R16", "type": "Has_temporal", "arg1_id": "NCT02781610_exc_T25", "arg2_id": "NCT02781610_exc_T31", "normalized": [] }, { "id": "NCT02781610_exc_R17", "type": "Subsumes", "arg1_id": "NCT02781610_exc_T35", "arg2_id": "NCT02781610_exc_T36", "normalized": [] }, { "id": "NCT02781610_exc_R18", "type": "AND", "arg1_id": "NCT02781610_exc_T34", "arg2_id": "NCT02781610_exc_T35", "normalized": [] }, { "id": "NCT02781610_exc_R19", "type": "Has_multiplier", "arg1_id": "NCT02781610_exc_T37", "arg2_id": "NCT02781610_exc_T39", "normalized": [] }, { "id": "NCT02781610_exc_R20", "type": "Has_temporal", "arg1_id": "NCT02781610_exc_T37", "arg2_id": "NCT02781610_exc_T38", "normalized": [] }, { "id": "NCT02781610_exc_R21", "type": "Has_index", "arg1_id": "NCT02781610_exc_T38", "arg2_id": "NCT02781610_exc_T40", "normalized": [] }, { "id": "NCT02781610_exc_R22", "type": "Has_qualifier", "arg1_id": "NCT02781610_exc_T42", "arg2_id": "NCT02781610_exc_T43", "normalized": [] }, { "id": "NCT02781610_exc_R23", "type": "Subsumes", "arg1_id": "NCT02781610_exc_T43", "arg2_id": "NCT02781610_exc_T44", "normalized": [] }, { "id": "NCT02781610_exc_R24", "type": "Subsumes", "arg1_id": "NCT02781610_exc_T43", "arg2_id": "NCT02781610_exc_T45", "normalized": [] }, { "id": "NCT02781610_exc_R25", "type": "Has_index", "arg1_id": "NCT02781610_exc_T46", "arg2_id": "NCT02781610_exc_T47", "normalized": [] }, { "id": "NCT02781610_exc_R26", "type": "Has_temporal", "arg1_id": "NCT02781610_exc_T42", "arg2_id": "NCT02781610_exc_T46", "normalized": [] } ]

[ { "id": "NCT02781610_inc_text", "type": "inclusion", "text": [ "Male or female =18 years of age at Visit 1\nDocumentation of a CF diagnosis\nEnrolled in the Cystic Fibrosis Foundation National Patient Registry (CFFNPR) prior to Visit 1 (US sites only)\nAt the time of Visit 1, there is a plan to initiate IV antibiotics for a pulmonary exacerbation\nPerformed spirometry at Visit 1 and Visit 2 and willing to perform spirometry at Visit 3\nCompleted the CRISS questionnaire at Visit 1 and Visit 2 and willing to complete the Cystic Fibrosis Respiratory Symptoms Diary (CFRSD) questionnaire at Visit 3\nWilling to adhere to a specific treatment duration determined by initial response to treatment and subsequent randomization\nWilling to return for follow up Visit 3\nWritten informed consent obtained from the subject or subject's legal representative\n" ], "offsets": [ [ 0, 781 ] ] } ]

[ { "id": "NCT02781610_inc_T1", "type": "Person", "text": [ "Male" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T2", "type": "Person", "text": [ "female" ], "offsets": [ [ 8, 14 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T3", "type": "Person", "text": [ "age" ], "offsets": [ [ 28, 31 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T4", "type": "Value", "text": [ "=18 years" ], "offsets": [ [ 15, 24 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T5", "type": "Temporal", "text": [ "at Visit 1" ], "offsets": [ [ 32, 42 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T6", "type": "Reference_point", "text": [ "Visit 1" ], "offsets": [ [ 35, 42 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T7", "type": "Condition", "text": [ "CF" ], "offsets": [ [ 62, 64 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T10", "type": "Drug", "text": [ "IV antibiotics" ], "offsets": [ [ 238, 252 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T11", "type": "Condition", "text": [ "pulmonary exacerbation" ], "offsets": [ [ 259, 281 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T12", "type": "Temporal", "text": [ "At the time of Visit 1" ], "offsets": [ [ 186, 208 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T13", "type": "Reference_point", "text": [ "Visit 1" ], "offsets": [ [ 201, 208 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T14", "type": "Procedure", "text": [ "spirometry" ], "offsets": [ [ 292, 302 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T15", "type": "Temporal", "text": [ "at Visit 1" ], "offsets": [ [ 303, 313 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T16", "type": "Temporal", "text": [ "is", "t 2 and" ], "offsets": [ [ 307, 309 ], [ 322, 329 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T17", "type": "Temporal", "text": [ "at Visit 3" ], "offsets": [ [ 360, 370 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T18", "type": "Scope", "text": [ "at Visit 1 and Visit 2" ], "offsets": [ [ 303, 325 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T8", "type": "Mood", "text": [ "willing to perform" ], "offsets": [ [ 330, 348 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T9", "type": "Procedure", "text": [ "spirometry" ], "offsets": [ [ 349, 359 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T23", "type": "Reference_point", "text": [ "Visit 1" ], "offsets": [ [ 306, 313 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T24", "type": "Reference_point", "text": [ "Visit 2" ], "offsets": [ [ 318, 325 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T25", "type": "Reference_point", "text": [ "Visit 3" ], "offsets": [ [ 363, 370 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T19", "type": "Procedure", "text": [ "CRISS questionnaire" ], "offsets": [ [ 385, 404 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T26", "type": "Temporal", "text": [ "at Visit 1" ], "offsets": [ [ 405, 415 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T27", "type": "Temporal", "text": [ "si", " 2 an" ], "offsets": [ [ 410, 412 ], [ 425, 430 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T28", "type": "Reference_point", "text": [ "Visit 1" ], "offsets": [ [ 408, 415 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T29", "type": "Reference_point", "text": [ "Visit 2" ], "offsets": [ [ 420, 427 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T30", "type": "Scope", "text": [ "at Visit 1 and Visit 2" ], "offsets": [ [ 405, 427 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T31", "type": "Mood", "text": [ "willing to complete" ], "offsets": [ [ 432, 451 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T32", "type": "Procedure", "text": [ "Cystic Fibrosis Respiratory Symptoms Diary (CFRSD) questionnaire" ], "offsets": [ [ 456, 520 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T33", "type": "Temporal", "text": [ "at Visit 3" ], "offsets": [ [ 521, 531 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T34", "type": "Reference_point", "text": [ "Visit 3" ], "offsets": [ [ 524, 531 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T35", "type": "Observation", "text": [ "Enrolled in the Cystic Fibrosis Foundation National Patient Registry (CFFNPR)" ], "offsets": [ [ 75, 152 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T36", "type": "Temporal", "text": [ "prior to Visit 1" ], "offsets": [ [ 153, 169 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T37", "type": "Reference_point", "text": [ "Visit 1" ], "offsets": [ [ 162, 169 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T38", "type": "Visit", "text": [ "US sites" ], "offsets": [ [ 171, 179 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T20", "type": "Mood", "text": [ "Willing to" ], "offsets": [ [ 532, 542 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T21", "type": "Mood", "text": [ "Willing to" ], "offsets": [ [ 656, 666 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T41", "type": "Procedure", "text": [ "follow up Visit 3" ], "offsets": [ [ 678, 695 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T22", "type": "Observation", "text": [ "Written informed consent" ], "offsets": [ [ 696, 720 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T40", "type": "Qualifier", "text": [ "from the subject" ], "offsets": [ [ 730, 746 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T42", "type": "Qualifier", "text": [ " subjec", "s legal representative" ], "offsets": [ [ 738, 745 ], [ 758, 780 ] ], "normalized": [] }, { "id": "NCT02781610_inc_T43", "type": "Scope", "text": [ "from the subject or subject's legal representative" ], "offsets": [ [ 730, 780 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02781610_inc_R1", "type": "Has_value", "arg1_id": "NCT02781610_inc_T3", "arg2_id": "NCT02781610_inc_T4", "normalized": [] }, { "id": "NCT02781610_inc_R2", "type": "Has_index", "arg1_id": "NCT02781610_inc_T5", "arg2_id": "NCT02781610_inc_T6", "normalized": [] }, { "id": "NCT02781610_inc_R3", "type": "Has_temporal", "arg1_id": "NCT02781610_inc_T3", "arg2_id": "NCT02781610_inc_T5", "normalized": [] }, { "id": "NCT02781610_inc_R4", "type": "AND", "arg1_id": "NCT02781610_inc_T10", "arg2_id": "NCT02781610_inc_T11", "normalized": [] }, { "id": "NCT02781610_inc_R5", "type": "Has_index", "arg1_id": "NCT02781610_inc_T12", "arg2_id": "NCT02781610_inc_T13", "normalized": [] }, { "id": "NCT02781610_inc_R6", "type": "Has_temporal", "arg1_id": "NCT02781610_inc_T10", "arg2_id": "NCT02781610_inc_T12", "normalized": [] }, { "id": "NCT02781610_inc_R7", "type": "Has_scope", "arg1_id": "NCT02781610_inc_T14", "arg2_id": "NCT02781610_inc_T18", "normalized": [] }, { "id": "NCT02781610_inc_R8", "type": "Has_temporal", "arg1_id": "NCT02781610_inc_T9", "arg2_id": "NCT02781610_inc_T17", "normalized": [] }, { "id": "NCT02781610_inc_R9", "type": "Has_mood", "arg1_id": "NCT02781610_inc_T9", "arg2_id": "NCT02781610_inc_T8", "normalized": [] }, { "id": "NCT02781610_inc_R10", "type": "Has_index", "arg1_id": "NCT02781610_inc_T15", "arg2_id": "NCT02781610_inc_T23", "normalized": [] }, { "id": "NCT02781610_inc_R11", "type": "Has_index", "arg1_id": "NCT02781610_inc_T16", "arg2_id": "NCT02781610_inc_T24", "normalized": [] }, { "id": "NCT02781610_inc_R12", "type": "Has_index", "arg1_id": "NCT02781610_inc_T17", "arg2_id": "NCT02781610_inc_T25", "normalized": [] }, { "id": "NCT02781610_inc_R13", "type": "Has_index", "arg1_id": "NCT02781610_inc_T26", "arg2_id": "NCT02781610_inc_T28", "normalized": [] }, { "id": "NCT02781610_inc_R14", "type": "Has_scope", "arg1_id": "NCT02781610_inc_T19", "arg2_id": "NCT02781610_inc_T30", "normalized": [] }, { "id": "NCT02781610_inc_R15", "type": "Has_mood", "arg1_id": "NCT02781610_inc_T32", "arg2_id": "NCT02781610_inc_T31", "normalized": [] }, { "id": "NCT02781610_inc_R16", "type": "Has_index", "arg1_id": "NCT02781610_inc_T33", "arg2_id": "NCT02781610_inc_T34", "normalized": [] }, { "id": "NCT02781610_inc_R17", "type": "Has_temporal", "arg1_id": "NCT02781610_inc_T32", "arg2_id": "NCT02781610_inc_T33", "normalized": [] }, { "id": "NCT02781610_inc_R18", "type": "Has_index", "arg1_id": "NCT02781610_inc_T36", "arg2_id": "NCT02781610_inc_T37", "normalized": [] }, { "id": "NCT02781610_inc_R19", "type": "Has_temporal", "arg1_id": "NCT02781610_inc_T35", "arg2_id": "NCT02781610_inc_T36", "normalized": [] }, { "id": "NCT02781610_inc_R21", "type": "Has_mood", "arg1_id": "NCT02781610_inc_T41", "arg2_id": "NCT02781610_inc_T21", "normalized": [] }, { "id": "NCT02781610_inc_R22", "type": "Has_scope", "arg1_id": "NCT02781610_inc_T22", "arg2_id": "NCT02781610_inc_T43", "normalized": [] } ]

[ { "id": "NCT02782702_exc_text", "type": "exclusion", "text": [ "Hypersensibility to toxin or excipients \nMyastheny \nDeglutition's problems \nPast medical history of dysphagia or aspiration pneumonia \nPregnancy (positive B-HCG test performed a maxima 72h before) or breastfeeding \nMental , physical incapacity to fill in the questionnaires \nGuardianship patients \nSkin infections at the inclusion visit \nApplication in the last 7 days at the site of injection of local treatments (apart emollients or antiseptics) or injections of botulism toxin or dynamic phototherapy or laser in the last 6 months. \nSystemic treatment with aminosides in the last 15 days \nInclusion in another study in the last 2 months. \n \n" ], "offsets": [ [ 0, 653 ] ] } ]

[ { "id": "NCT02782702_exc_T1", "type": "Condition", "text": [ "Hypersensibility" ], "offsets": [ [ 0, 16 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T2", "type": "Drug", "text": [ "toxin" ], "offsets": [ [ 20, 25 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T3", "type": "Drug", "text": [ "excipients" ], "offsets": [ [ 29, 39 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T4", "type": "Scope", "text": [ "toxin or excipients" ], "offsets": [ [ 20, 39 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T6", "type": "Condition", "text": [ "Myastheny" ], "offsets": [ [ 41, 50 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T7", "type": "Condition", "text": [ "Deglutition's problems" ], "offsets": [ [ 52, 74 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T8", "type": "Condition", "text": [ "dysphagia" ], "offsets": [ [ 100, 109 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T9", "type": "Observation", "text": [ "Past medical history" ], "offsets": [ [ 76, 96 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T10", "type": "Condition", "text": [ "aspiration pneumonia" ], "offsets": [ [ 113, 133 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T11", "type": "Scope", "text": [ "dysphagia or aspiration pneumonia" ], "offsets": [ [ 100, 133 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T12", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 135, 144 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T13", "type": "Measurement", "text": [ "B-HCG test" ], "offsets": [ [ 155, 165 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T14", "type": "Value", "text": [ "positive" ], "offsets": [ [ 146, 154 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T15", "type": "Observation", "text": [ "breastfeeding" ], "offsets": [ [ 200, 213 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T16", "type": "Temporal", "text": [ "a maxima 72h before" ], "offsets": [ [ 176, 195 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T20", "type": "Condition", "text": [ "Skin infections" ], "offsets": [ [ 298, 313 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T21", "type": "Temporal", "text": [ "at the inclusion visit" ], "offsets": [ [ 314, 336 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T22", "type": "Visit", "text": [ "inclusion visit" ], "offsets": [ [ 321, 336 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T23", "type": "Temporal", "text": [ "in the last 7 days" ], "offsets": [ [ 350, 368 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T24", "type": "Procedure", "text": [ "Application", "of local treatments" ], "offsets": [ [ 338, 349 ], [ 394, 413 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T25", "type": "Drug", "text": [ "emollients" ], "offsets": [ [ 421, 431 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T26", "type": "Drug", "text": [ "antiseptics" ], "offsets": [ [ 435, 446 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T27", "type": "Negation", "text": [ "apart" ], "offsets": [ [ 415, 420 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T28", "type": "Scope", "text": [ "emollients or antiseptics" ], "offsets": [ [ 421, 446 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T29", "type": "Drug", "text": [ "botulism toxin" ], "offsets": [ [ 465, 479 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T30", "type": "Procedure", "text": [ "injections" ], "offsets": [ [ 451, 461 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T31", "type": "Procedure", "text": [ "dynamic phototherapy" ], "offsets": [ [ 483, 503 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T32", "type": "Procedure", "text": [ "laser" ], "offsets": [ [ 507, 512 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T33", "type": "Temporal", "text": [ "in the last 6 months" ], "offsets": [ [ 513, 533 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T34", "type": "Scope", "text": [ "injections of botulism toxin or dynamic phototherapy or laser" ], "offsets": [ [ 451, 512 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T35", "type": "Procedure", "text": [ "Systemic treatment" ], "offsets": [ [ 536, 554 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T36", "type": "Drug", "text": [ "aminosides" ], "offsets": [ [ 560, 570 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T37", "type": "Temporal", "text": [ "in the last 15 days" ], "offsets": [ [ 571, 590 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T41", "type": "Temporal", "text": [ "in the last 2 months" ], "offsets": [ [ 619, 639 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T42", "type": "Procedure", "text": [ "Inclusion in another study" ], "offsets": [ [ 592, 618 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T5", "type": "Condition", "text": [ "physical incapacity" ], "offsets": [ [ 224, 243 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T17", "type": "Condition", "text": [ "Mental", "incapacity" ], "offsets": [ [ 215, 221 ], [ 233, 243 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T18", "type": "Procedure", "text": [ "fill in the questionnaires" ], "offsets": [ [ 247, 273 ] ], "normalized": [] }, { "id": "NCT02782702_exc_T43", "type": "Scope", "text": [ "Mental , physical incapacity" ], "offsets": [ [ 215, 243 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02782702_exc_R1", "type": "Has_scope", "arg1_id": "NCT02782702_exc_T1", "arg2_id": "NCT02782702_exc_T4", "normalized": [] }, { "id": "NCT02782702_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02782702_exc_T11", "arg2_id": "NCT02782702_exc_T9", "normalized": [] }, { "id": "NCT02782702_exc_R3", "type": "Has_value", "arg1_id": "NCT02782702_exc_T13", "arg2_id": "NCT02782702_exc_T14", "normalized": [] }, { "id": "NCT02782702_exc_R4", "type": "AND", "arg1_id": "NCT02782702_exc_T12", "arg2_id": "NCT02782702_exc_T13", "normalized": [] }, { "id": "NCT02782702_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02782702_exc_T13", "arg2_id": "NCT02782702_exc_T16", "normalized": [] }, { "id": "NCT02782702_exc_R6", "type": "AND", "arg1_id": "NCT02782702_exc_T21", "arg2_id": "NCT02782702_exc_T22", "normalized": [] }, { "id": "NCT02782702_exc_R7", "type": "Has_temporal", "arg1_id": "NCT02782702_exc_T20", "arg2_id": "NCT02782702_exc_T21", "normalized": [] }, { "id": "NCT02782702_exc_R8", "type": "Has_negation", "arg1_id": "NCT02782702_exc_T28", "arg2_id": "NCT02782702_exc_T27", "normalized": [] }, { "id": "NCT02782702_exc_R9", "type": "Has_scope", "arg1_id": "NCT02782702_exc_T24", "arg2_id": "NCT02782702_exc_T28", "normalized": [] }, { "id": "NCT02782702_exc_R10", "type": "Has_temporal", "arg1_id": "NCT02782702_exc_T24", "arg2_id": "NCT02782702_exc_T23", "normalized": [] }, { "id": "NCT02782702_exc_R11", "type": "AND", "arg1_id": "NCT02782702_exc_T30", "arg2_id": "NCT02782702_exc_T29", "normalized": [] }, { "id": "NCT02782702_exc_R12", "type": "Has_temporal", "arg1_id": "NCT02782702_exc_T34", "arg2_id": "NCT02782702_exc_T33", "normalized": [] }, { "id": "NCT02782702_exc_R13", "type": "AND", "arg1_id": "NCT02782702_exc_T35", "arg2_id": "NCT02782702_exc_T36", "normalized": [] }, { "id": "NCT02782702_exc_R14", "type": "Has_temporal", "arg1_id": "NCT02782702_exc_T35", "arg2_id": "NCT02782702_exc_T37", "normalized": [] }, { "id": "NCT02782702_exc_R15", "type": "Has_temporal", "arg1_id": "NCT02782702_exc_T42", "arg2_id": "NCT02782702_exc_T41", "normalized": [] }, { "id": "NCT02782702_exc_R16", "type": "AND", "arg1_id": "NCT02782702_exc_T43", "arg2_id": "NCT02782702_exc_T18", "normalized": [] } ]

[ { "id": "NCT02782702_inc_text", "type": "inclusion", "text": [ "Confirmed diagnosis (clinical and histological features) of Hailey Hailey or Darier diseases. \nModerate to very severe lesions located in large folds \nPatient aged 18 ans or more \nPatient with health coverage \nPatient who have signed the consent form \nPatient proficient into filling out the questionnaires. \n" ], "offsets": [ [ 0, 309 ] ] } ]

[ { "id": "NCT02782702_inc_T1", "type": "Condition", "text": [ "Hailey Hailey", "disease" ], "offsets": [ [ 60, 73 ], [ 84, 91 ] ], "normalized": [] }, { "id": "NCT02782702_inc_T2", "type": "Condition", "text": [ "Darier disease" ], "offsets": [ [ 77, 91 ] ], "normalized": [] }, { "id": "NCT02782702_inc_T3", "type": "Procedure", "text": [ "histological" ], "offsets": [ [ 34, 46 ] ], "normalized": [] }, { "id": "NCT02782702_inc_T4", "type": "Scope", "text": [ "Hailey Hailey or Darier diseases" ], "offsets": [ [ 60, 92 ] ], "normalized": [] }, { "id": "NCT02782702_inc_T5", "type": "Condition", "text": [ "lesions" ], "offsets": [ [ 119, 126 ] ], "normalized": [] }, { "id": "NCT02782702_inc_T7", "type": "Qualifier", "text": [ "very severe" ], "offsets": [ [ 107, 118 ] ], "normalized": [] }, { "id": "NCT02782702_inc_T10", "type": "Person", "text": [ "aged" ], "offsets": [ [ 159, 163 ] ], "normalized": [] }, { "id": "NCT02782702_inc_T11", "type": "Value", "text": [ "18 ans or more" ], "offsets": [ [ 164, 178 ] ], "normalized": [] }, { "id": "NCT02782702_inc_T12", "type": "Observation", "text": [ "health coverage" ], "offsets": [ [ 193, 208 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02782702_inc_R1", "type": "AND", "arg1_id": "NCT02782702_inc_T4", "arg2_id": "NCT02782702_inc_T3", "normalized": [] }, { "id": "NCT02782702_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02782702_inc_T5", "arg2_id": "NCT02782702_inc_T7", "normalized": [] }, { "id": "NCT02782702_inc_R3", "type": "Has_value", "arg1_id": "NCT02782702_inc_T10", "arg2_id": "NCT02782702_inc_T11", "normalized": [] } ]

[ { "id": "NCT02783859_exc_text", "type": "exclusion", "text": [ "Current wheeze\nUnderlying chronic illness other than asthma (e.g. bronchiectasis, cyanotic congenital heart disease or cardiac failure, neuromuscular disorders, immunodeficiency) that could potentially influence the current illness\nSevere malnutrition (weight-for-height Z-score <-3)\nComplicated (effusion, empyema or abscess) pneumonia, including tuberculosis\nExtra-pulmonary infection requiring antibiotic therapy (e.g. meningitis)\nBeta-lactam allergy\nPreviously enrolled\nLack a mobile phone and/or unable to return for follow-up clinic visits during the next 24 months\n" ], "offsets": [ [ 0, 572 ] ] } ]

[ { "id": "NCT02783859_exc_T1", "type": "Condition", "text": [ "wheeze" ], "offsets": [ [ 8, 14 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T2", "type": "Condition", "text": [ "chronic illness" ], "offsets": [ [ 26, 41 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T3", "type": "Negation", "text": [ "other" ], "offsets": [ [ 42, 47 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T4", "type": "Condition", "text": [ "asthma" ], "offsets": [ [ 53, 59 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T5", "type": "Condition", "text": [ "bronchiectasis" ], "offsets": [ [ 66, 80 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T6", "type": "Condition", "text": [ "cyanotic congenital heart disease" ], "offsets": [ [ 82, 115 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T7", "type": "Condition", "text": [ "cardiac failure" ], "offsets": [ [ 119, 134 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T8", "type": "Condition", "text": [ "neuromuscular disorders" ], "offsets": [ [ 136, 159 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T9", "type": "Condition", "text": [ "immunodeficiency" ], "offsets": [ [ 161, 177 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T10", "type": "Scope", "text": [ "bronchiectasis, cyanotic congenital heart disease or cardiac failure, neuromuscular disorders, immunodeficiency" ], "offsets": [ [ 66, 177 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T11", "type": "Condition", "text": [ "malnutrition" ], "offsets": [ [ 239, 251 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T12", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 232, 238 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T13", "type": "Measurement", "text": [ "weight-for-height Z-score" ], "offsets": [ [ 253, 278 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T14", "type": "Value", "text": [ "<-3" ], "offsets": [ [ 279, 282 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T15", "type": "Condition", "text": [ "plicated (e", "umonia, i" ], "offsets": [ [ 287, 298 ], [ 330, 339 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T16", "type": "Condition", "text": [ "tuberculosis" ], "offsets": [ [ 348, 360 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T17", "type": "Condition", "text": [ "effusion" ], "offsets": [ [ 297, 305 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T18", "type": "Condition", "text": [ "empyema" ], "offsets": [ [ 307, 314 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T19", "type": "Condition", "text": [ "abscess" ], "offsets": [ [ 318, 325 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T20", "type": "Scope", "text": [ "ffusion, empyema or abscess" ], "offsets": [ [ 298, 325 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T21", "type": "Qualifier", "text": [ "Extra-pulmonary" ], "offsets": [ [ 361, 376 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T22", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 377, 386 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T23", "type": "Procedure", "text": [ "antibiotic therapy" ], "offsets": [ [ 397, 415 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T24", "type": "Condition", "text": [ "meningitis" ], "offsets": [ [ 422, 432 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T25", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 446, 453 ] ], "normalized": [] }, { "id": "NCT02783859_exc_T26", "type": "Drug", "text": [ "Beta-lactam" ], "offsets": [ [ 434, 445 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02783859_exc_R1", "type": "Has_negation", "arg1_id": "NCT02783859_exc_T4", "arg2_id": "NCT02783859_exc_T3", "normalized": [] }, { "id": "NCT02783859_exc_R2", "type": "Subsumes", "arg1_id": "NCT02783859_exc_T2", "arg2_id": "NCT02783859_exc_T10", "normalized": [] }, { "id": "NCT02783859_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02783859_exc_T11", "arg2_id": "NCT02783859_exc_T12", "normalized": [] }, { "id": "NCT02783859_exc_R4", "type": "Has_value", "arg1_id": "NCT02783859_exc_T13", "arg2_id": "NCT02783859_exc_T14", "normalized": [] }, { "id": "NCT02783859_exc_R5", "type": "AND", "arg1_id": "NCT02783859_exc_T11", "arg2_id": "NCT02783859_exc_T13", "normalized": [] }, { "id": "NCT02783859_exc_R6", "type": "Subsumes", "arg1_id": "NCT02783859_exc_T15", "arg2_id": "NCT02783859_exc_T16", "normalized": [] }, { "id": "NCT02783859_exc_R7", "type": "Subsumes", "arg1_id": "NCT02783859_exc_T15", "arg2_id": "NCT02783859_exc_T20", "normalized": [] }, { "id": "NCT02783859_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT02783859_exc_T22", "arg2_id": "NCT02783859_exc_T21", "normalized": [] }, { "id": "NCT02783859_exc_R9", "type": "Subsumes", "arg1_id": "NCT02783859_exc_T22", "arg2_id": "NCT02783859_exc_T24", "normalized": [] }, { "id": "NCT02783859_exc_R10", "type": "AND", "arg1_id": "NCT02783859_exc_T22", "arg2_id": "NCT02783859_exc_T23", "normalized": [] }, { "id": "NCT02783859_exc_R11", "type": "AND", "arg1_id": "NCT02783859_exc_T25", "arg2_id": "NCT02783859_exc_T26", "normalized": [] } ]

[ { "id": "NCT02783859_inc_text", "type": "inclusion", "text": [ "Hospitalised children aged 3-mo to 5-yrs (in Darwin, children have to be Indigenous)\nHave features of severe pneumonia on admission (temperature >37.5 celsius or a history of fever at home or observed at the referring clinic, age-adjusted tachypnoea [respiratory rate>50 if <12-months; respiratory rate>40 if >12-months] with chest wall recession and/or oxygen saturation <92% in air), and consolidation on chest X-ray as diagnosed by treating clinician\nAfter 1-3 days of IV antibiotics, are afebrile, with improved respiratory symptoms and signs, oxygen saturation>90% in air and are ready to be switched to oral amoxicillin-clavulanate, and\nHave symptoms of no longer than 7 days at point of hospitalisation.\n" ], "offsets": [ [ 0, 711 ] ] } ]

[ { "id": "NCT02783859_inc_T1", "type": "Visit", "text": [ "Hospitalised" ], "offsets": [ [ 0, 12 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T2", "type": "Person", "text": [ "children" ], "offsets": [ [ 13, 21 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T3", "type": "Person", "text": [ "aged" ], "offsets": [ [ 22, 26 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T4", "type": "Value", "text": [ "3-mo to 5-yrs" ], "offsets": [ [ 27, 40 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T5", "type": "Condition", "text": [ "pneumonia" ], "offsets": [ [ 109, 118 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T6", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 102, 108 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T7", "type": "Measurement", "text": [ "temperature" ], "offsets": [ [ 133, 144 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T8", "type": "Value", "text": [ ">37.5 celsius" ], "offsets": [ [ 145, 158 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T9", "type": "Person", "text": [ "age" ], "offsets": [ [ 226, 229 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T10", "type": "Condition", "text": [ "tachypnoea" ], "offsets": [ [ 239, 249 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T11", "type": "Measurement", "text": [ "respiratory rate" ], "offsets": [ [ 251, 267 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T12", "type": "Value", "text": [ ">50" ], "offsets": [ [ 267, 270 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T13", "type": "Value", "text": [ "<12-months" ], "offsets": [ [ 274, 284 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T14", "type": "Value", "text": [ ">12-months" ], "offsets": [ [ 309, 319 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T15", "type": "Measurement", "text": [ "respiratory rate" ], "offsets": [ [ 286, 302 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T16", "type": "Value", "text": [ ">40" ], "offsets": [ [ 302, 305 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T17", "type": "Person", "text": [ "age" ], "offsets": [ [ 226, 229 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T18", "type": "Condition", "text": [ "chest wall recession" ], "offsets": [ [ 326, 346 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T19", "type": "Measurement", "text": [ "oxygen saturation" ], "offsets": [ [ 354, 371 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T20", "type": "Value", "text": [ "<92% in air" ], "offsets": [ [ 372, 383 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T21", "type": "Scope", "text": [ "chest wall recession and/or oxygen saturation <92% in air" ], "offsets": [ [ 326, 383 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T22", "type": "Scope", "text": [ "temperature >37.5 celsius or a history of fever at home or observed at the referring clinic, age-adjusted tachypnoea [respiratory rate>50 if <12-months; respiratory rate>40 if >12-months] with chest wall recession and/or oxygen saturation <92% in air" ], "offsets": [ [ 133, 383 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T23", "type": "Condition", "text": [ "consolidation" ], "offsets": [ [ 390, 403 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T24", "type": "Procedure", "text": [ "chest X-ray" ], "offsets": [ [ 407, 418 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T26", "type": "Condition", "text": [ "symptoms" ], "offsets": [ [ 648, 656 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T27", "type": "Temporal", "text": [ "no longer than 7 days at point of hospitalisation" ], "offsets": [ [ 660, 709 ] ], "normalized": [] }, { "id": "NCT02783859_inc_T28", "type": "Reference_point", "text": [ "hospitalisation" ], "offsets": [ [ 694, 709 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02783859_inc_R1", "type": "Has_value", "arg1_id": "NCT02783859_inc_T3", "arg2_id": "NCT02783859_inc_T4", "normalized": [] }, { "id": "NCT02783859_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02783859_inc_T5", "arg2_id": "NCT02783859_inc_T6", "normalized": [] }, { "id": "NCT02783859_inc_R3", "type": "Has_value", "arg1_id": "NCT02783859_inc_T7", "arg2_id": "NCT02783859_inc_T8", "normalized": [] }, { "id": "NCT02783859_inc_R4", "type": "Has_value", "arg1_id": "NCT02783859_inc_T11", "arg2_id": "NCT02783859_inc_T12", "normalized": [] }, { "id": "NCT02783859_inc_R5", "type": "Has_value", "arg1_id": "NCT02783859_inc_T15", "arg2_id": "NCT02783859_inc_T16", "normalized": [] }, { "id": "NCT02783859_inc_R6", "type": "Has_value", "arg1_id": "NCT02783859_inc_T17", "arg2_id": "NCT02783859_inc_T13", "normalized": [] }, { "id": "NCT02783859_inc_R7", "type": "Has_value", "arg1_id": "NCT02783859_inc_T9", "arg2_id": "NCT02783859_inc_T14", "normalized": [] }, { "id": "NCT02783859_inc_R8", "type": "AND", "arg1_id": "NCT02783859_inc_T9", "arg2_id": "NCT02783859_inc_T15", "normalized": [] }, { "id": "NCT02783859_inc_R9", "type": "AND", "arg1_id": "NCT02783859_inc_T17", "arg2_id": "NCT02783859_inc_T11", "normalized": [] }, { "id": "NCT02783859_inc_R10", "type": "AND", "arg1_id": "NCT02783859_inc_T10", "arg2_id": "NCT02783859_inc_T17", "normalized": [] }, { "id": "NCT02783859_inc_R11", "type": "AND", "arg1_id": "NCT02783859_inc_T10", "arg2_id": "NCT02783859_inc_T9", "normalized": [] }, { "id": "NCT02783859_inc_R12", "type": "Has_value", "arg1_id": "NCT02783859_inc_T19", "arg2_id": "NCT02783859_inc_T20", "normalized": [] }, { "id": "NCT02783859_inc_R13", "type": "Has_scope", "arg1_id": "NCT02783859_inc_T10", "arg2_id": "NCT02783859_inc_T21", "normalized": [] }, { "id": "NCT02783859_inc_R14", "type": "Subsumes", "arg1_id": "NCT02783859_inc_T5", "arg2_id": "NCT02783859_inc_T22", "normalized": [] }, { "id": "NCT02783859_inc_R15", "type": "AND", "arg1_id": "NCT02783859_inc_T24", "arg2_id": "NCT02783859_inc_T23", "normalized": [] }, { "id": "NCT02783859_inc_R16", "type": "Has_index", "arg1_id": "NCT02783859_inc_T27", "arg2_id": "NCT02783859_inc_T28", "normalized": [] }, { "id": "NCT02783859_inc_R17", "type": "Has_temporal", "arg1_id": "NCT02783859_inc_T26", "arg2_id": "NCT02783859_inc_T27", "normalized": [] } ]

[ { "id": "NCT02785549_exc_text", "type": "exclusion", "text": [ "NA\n\n" ], "offsets": [ [ 0, 4 ] ] } ]

[]

[]

[]

[]

[ { "id": "NCT02785549_inc_text", "type": "inclusion", "text": [ "Patient's written informed consent. Adequate cognitive capacity.\nAdequate family support\nNo acute diverticulitis episode in the last 3 months\nmNeff 0 acute diverticulitis (abdominal computed tomography scan)\nNo antibiotic treatment in the last 2 weeks\nImmunocompetence*\nNo significant comorbidities**\nGood oral tolerance\nGood symptom control\nMaximum one of the following SIRS criteria (* T>38 ºC or <36ºC, L>12,000 or <4000/uL, HR>90 bpm, RR<20 rpm) or CRP>15 mg/dL\n" ], "offsets": [ [ 0, 466 ] ] } ]

[ { "id": "NCT02785549_inc_T3", "type": "Condition", "text": [ "diverticulitis" ], "offsets": [ [ 98, 112 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T4", "type": "Qualifier", "text": [ "acute" ], "offsets": [ [ 92, 97 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T5", "type": "Temporal", "text": [ "in the last 3 months" ], "offsets": [ [ 121, 141 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T6", "type": "Measurement", "text": [ "mNeff" ], "offsets": [ [ 142, 147 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T7", "type": "Value", "text": [ "0" ], "offsets": [ [ 148, 149 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T8", "type": "Condition", "text": [ "diverticulitis" ], "offsets": [ [ 156, 170 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T9", "type": "Qualifier", "text": [ "acute" ], "offsets": [ [ 150, 155 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T10", "type": "Procedure", "text": [ "abdominal computed tomography scan" ], "offsets": [ [ 172, 206 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T11", "type": "Drug", "text": [ "antibiotic treatment" ], "offsets": [ [ 211, 231 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T12", "type": "Temporal", "text": [ "in the last 2 weeks" ], "offsets": [ [ 232, 251 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T13", "type": "Negation", "text": [ "No" ], "offsets": [ [ 208, 210 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T14", "type": "Condition", "text": [ "Immunocompetence" ], "offsets": [ [ 252, 268 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T15", "type": "Condition", "text": [ "comorbidities" ], "offsets": [ [ 285, 298 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T16", "type": "Negation", "text": [ "No" ], "offsets": [ [ 270, 272 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T17", "type": "Qualifier", "text": [ "significant" ], "offsets": [ [ 273, 284 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T18", "type": "Condition", "text": [ "oral tolerance" ], "offsets": [ [ 306, 320 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T19", "type": "Qualifier", "text": [ "Good" ], "offsets": [ [ 301, 305 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T20", "type": "Condition", "text": [ "symptom control" ], "offsets": [ [ 326, 341 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T21", "type": "Qualifier", "text": [ "Good" ], "offsets": [ [ 321, 325 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T22", "type": "Measurement", "text": [ "SIRS criteria" ], "offsets": [ [ 371, 384 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T23", "type": "Measurement", "text": [ "T" ], "offsets": [ [ 388, 389 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T24", "type": "Value", "text": [ ">38 ºC" ], "offsets": [ [ 389, 395 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T25", "type": "Value", "text": [ "<36ºC" ], "offsets": [ [ 399, 404 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T26", "type": "Measurement", "text": [ "L" ], "offsets": [ [ 406, 407 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T27", "type": "Value", "text": [ "r <4000", "0 b" ], "offsets": [ [ 416, 423 ], [ 432, 435 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T28", "type": "Value", "text": [ "<4000/uL" ], "offsets": [ [ 418, 426 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T29", "type": "Measurement", "text": [ "HR" ], "offsets": [ [ 428, 430 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T30", "type": "Value", "text": [ ">90 bpm" ], "offsets": [ [ 430, 437 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T31", "type": "Measurement", "text": [ "RR" ], "offsets": [ [ 439, 441 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T32", "type": "Value", "text": [ "<20 rpm" ], "offsets": [ [ 441, 448 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T33", "type": "Measurement", "text": [ "CRP" ], "offsets": [ [ 453, 456 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T34", "type": "Value", "text": [ ">15 mg/dL" ], "offsets": [ [ 456, 465 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T35", "type": "Scope", "text": [ ">38 ºC or <36ºC" ], "offsets": [ [ 389, 404 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T36", "type": "Scope", "text": [ ">12,000 or <4000/uL" ], "offsets": [ [ 407, 426 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T37", "type": "Scope", "text": [ "Patient's written informed consent. Adequate cognitive capacity.", "dequate family support\nN", " acute diverticulitis episode in the last 3 months\nm", "ff 0 acute diverticulitis (abdominal computed tomography scan)\nNo", "ntibiotic treatment in the last 2 weeks\nImmu", "ocompetence*\nNo si", "nificant comorbidities**\nGood o", "al tolerance\nGood sy", "ptom control\nMaximum", "ne of the following SIRS criteria (* T>38 ºC or <36ºC, L>12,000 or <4000/uL, HR>90 bpm, RR<20 rpm) or CRP>1" ], "offsets": [ [ 0, 64 ], [ 66, 90 ], [ 91, 143 ], [ 145, 210 ], [ 212, 256 ], [ 257, 275 ], [ 276, 307 ], [ 308, 328 ], [ 329, 349 ], [ 351, 458 ] ], "normalized": [] }, { "id": "NCT02785549_inc_T38", "type": "Scope", "text": [ "(* T>38 ºC or <36ºC, L>12,000 or <4000/uL, HR>90 bpm, RR<20 rpm)" ], "offsets": [ [ 385, 449 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02785549_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT02785549_inc_T3", "arg2_id": "NCT02785549_inc_T4", "normalized": [] }, { "id": "NCT02785549_inc_R2", "type": "Has_temporal", "arg1_id": "NCT02785549_inc_T3", "arg2_id": "NCT02785549_inc_T5", "normalized": [] }, { "id": "NCT02785549_inc_R3", "type": "Has_value", "arg1_id": "NCT02785549_inc_T6", "arg2_id": "NCT02785549_inc_T7", "normalized": [] }, { "id": "NCT02785549_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT02785549_inc_T8", "arg2_id": "NCT02785549_inc_T9", "normalized": [] }, { "id": "NCT02785549_inc_R5", "type": "Has_negation", "arg1_id": "NCT02785549_inc_T11", "arg2_id": "NCT02785549_inc_T13", "normalized": [] }, { "id": "NCT02785549_inc_R6", "type": "Has_temporal", "arg1_id": "NCT02785549_inc_T11", "arg2_id": "NCT02785549_inc_T12", "normalized": [] }, { "id": "NCT02785549_inc_R7", "type": "Has_qualifier", "arg1_id": "NCT02785549_inc_T15", "arg2_id": "NCT02785549_inc_T17", "normalized": [] }, { "id": "NCT02785549_inc_R8", "type": "Has_negation", "arg1_id": "NCT02785549_inc_T15", "arg2_id": "NCT02785549_inc_T16", "normalized": [] }, { "id": "NCT02785549_inc_R9", "type": "Has_qualifier", "arg1_id": "NCT02785549_inc_T18", "arg2_id": "NCT02785549_inc_T19", "normalized": [] }, { "id": "NCT02785549_inc_R10", "type": "Has_qualifier", "arg1_id": "NCT02785549_inc_T20", "arg2_id": "NCT02785549_inc_T21", "normalized": [] }, { "id": "NCT02785549_inc_R11", "type": "Has_scope", "arg1_id": "NCT02785549_inc_T23", "arg2_id": "NCT02785549_inc_T35", "normalized": [] }, { "id": "NCT02785549_inc_R12", "type": "Has_scope", "arg1_id": "NCT02785549_inc_T26", "arg2_id": "NCT02785549_inc_T36", "normalized": [] }, { "id": "NCT02785549_inc_R13", "type": "Has_value", "arg1_id": "NCT02785549_inc_T29", "arg2_id": "NCT02785549_inc_T30", "normalized": [] }, { "id": "NCT02785549_inc_R14", "type": "Has_value", "arg1_id": "NCT02785549_inc_T31", "arg2_id": "NCT02785549_inc_T32", "normalized": [] }, { "id": "NCT02785549_inc_R15", "type": "Has_value", "arg1_id": "NCT02785549_inc_T33", "arg2_id": "NCT02785549_inc_T34", "normalized": [] }, { "id": "NCT02785549_inc_R16", "type": "Subsumes", "arg1_id": "NCT02785549_inc_T22", "arg2_id": "NCT02785549_inc_T38", "normalized": [] } ]

[ { "id": "NCT02787070_exc_text", "type": "exclusion", "text": [ "General danger signs or symptoms of severe malaria\nAnaemia, defined as Hb <9g/dl\nG6PD deficiency (as determined by FST)\nPregnant women as determined by Urine ß-HCG pregnancy test\nKnown hypersensitivity to any of the drugs given\n" ], "offsets": [ [ 0, 228 ] ] } ]

[ { "id": "NCT02787070_exc_T1", "type": "Condition", "text": [ "malaria" ], "offsets": [ [ 43, 50 ] ], "normalized": [] }, { "id": "NCT02787070_exc_T2", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 36, 42 ] ], "normalized": [] }, { "id": "NCT02787070_exc_T3", "type": "Condition", "text": [ "Anaemia" ], "offsets": [ [ 51, 58 ] ], "normalized": [] }, { "id": "NCT02787070_exc_T4", "type": "Measurement", "text": [ "Hb" ], "offsets": [ [ 71, 73 ] ], "normalized": [] }, { "id": "NCT02787070_exc_T5", "type": "Value", "text": [ "<9g/dl" ], "offsets": [ [ 74, 80 ] ], "normalized": [] }, { "id": "NCT02787070_exc_T6", "type": "Condition", "text": [ "G6PD deficiency" ], "offsets": [ [ 81, 96 ] ], "normalized": [] }, { "id": "NCT02787070_exc_T8", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 185, 201 ] ], "normalized": [] }, { "id": "NCT02787070_exc_T9", "type": "Drug", "text": [ "drugs" ], "offsets": [ [ 216, 221 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02787070_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02787070_exc_T1", "arg2_id": "NCT02787070_exc_T2", "normalized": [] }, { "id": "NCT02787070_exc_R2", "type": "Has_value", "arg1_id": "NCT02787070_exc_T4", "arg2_id": "NCT02787070_exc_T5", "normalized": [] }, { "id": "NCT02787070_exc_R3", "type": "AND", "arg1_id": "NCT02787070_exc_T3", "arg2_id": "NCT02787070_exc_T4", "normalized": [] }, { "id": "NCT02787070_exc_R4", "type": "AND", "arg1_id": "NCT02787070_exc_T8", "arg2_id": "NCT02787070_exc_T9", "normalized": [] } ]

[ { "id": "NCT02787070_inc_text", "type": "inclusion", "text": [ "Infection with Plasmodium falciparum or P. vivax either alone or mixed\nAge >12 months\nWeight >5kg\nLiving in the study clusters\n" ], "offsets": [ [ 0, 127 ] ] } ]

[ { "id": "NCT02787070_inc_T1", "type": "Condition", "text": [ "Infection" ], "offsets": [ [ 0, 9 ] ], "normalized": [] }, { "id": "NCT02787070_inc_T2", "type": "Qualifier", "text": [ "Plasmodium falciparum" ], "offsets": [ [ 15, 36 ] ], "normalized": [] }, { "id": "NCT02787070_inc_T3", "type": "Qualifier", "text": [ "P. vivax" ], "offsets": [ [ 40, 48 ] ], "normalized": [] }, { "id": "NCT02787070_inc_T4", "type": "Scope", "text": [ "Plasmodium falciparum or P. vivax" ], "offsets": [ [ 15, 48 ] ], "normalized": [] }, { "id": "NCT02787070_inc_T5", "type": "Person", "text": [ "Age" ], "offsets": [ [ 71, 74 ] ], "normalized": [] }, { "id": "NCT02787070_inc_T6", "type": "Value", "text": [ ">12 months" ], "offsets": [ [ 75, 85 ] ], "normalized": [] }, { "id": "NCT02787070_inc_T7", "type": "Person", "text": [ "Weight" ], "offsets": [ [ 86, 92 ] ], "normalized": [] }, { "id": "NCT02787070_inc_T8", "type": "Value", "text": [ ">5kg" ], "offsets": [ [ 93, 97 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02787070_inc_R1", "type": "Has_scope", "arg1_id": "NCT02787070_inc_T1", "arg2_id": "NCT02787070_inc_T4", "normalized": [] }, { "id": "NCT02787070_inc_R2", "type": "Has_value", "arg1_id": "NCT02787070_inc_T5", "arg2_id": "NCT02787070_inc_T6", "normalized": [] }, { "id": "NCT02787070_inc_R3", "type": "Has_value", "arg1_id": "NCT02787070_inc_T7", "arg2_id": "NCT02787070_inc_T8", "normalized": [] } ]

[ { "id": "NCT02787863_exc_text", "type": "exclusion", "text": [ "Vaccination against pneumococcal infection in anamnesis;\nApplication of preparations of immune globulin or blood transfusion within last three months prior to clinical studies;\nProlonged use (more than 14 days) immunosuppressants or other immunosuppressive drugs within 6 months prior to the start of the study;\nAny confirmed or suspected immunosuppressive or immunodeficient condition, including HIV infection;\nA history or currently hematologic and other cancers;\nA positive reaction for HIV infection, viral hepatitis B and hepatitis C;\nThe presence of respiratory, cardio-vascular insufficiency, impaired liver and kidney function, established during a physical examination at visit number 1;\nPronounced congenital defects or serious chronic diseases in the acute stage, including any clinically important exacerbation of chronic diseases of the liver, kidney, cardiovascular, nervous system, mental diseases or metabolic disorders, confirmed by the history or objective examination (pulmonary: cystic fibrosis, lung abscess, empyema, active tuberculosis; extra-pulmonary: congestive heart failure, malabsorption, chronic renal and hepatic failure, cirrhosis, malignancy, immunodeficiency, cirrhosis of the liver);\nSevere allergic reactions in anamnesis of autoimmune disease;\nThe presence of acute infectious and/or communicable illnesses within 1 month prior to study;\nHistory of chronic alcohol abuse and/or drug use;\nExacerbation of chronic diseases;\nBreastfeeding;\nPregnancy;\nParticipation in any other clinical study within the last 3 months.\n" ], "offsets": [ [ 0, 1553 ] ] } ]

[ { "id": "NCT02787863_exc_T1", "type": "Condition", "text": [ "pneumococcal infection" ], "offsets": [ [ 20, 42 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T2", "type": "Procedure", "text": [ "Vaccination" ], "offsets": [ [ 0, 11 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T3", "type": "Drug", "text": [ "preparations of immune globulin" ], "offsets": [ [ 72, 103 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T4", "type": "Procedure", "text": [ "blood transfusion" ], "offsets": [ [ 107, 124 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T5", "type": "Temporal", "text": [ "within last three months prior to clinical studies" ], "offsets": [ [ 125, 175 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T6", "type": "Scope", "text": [ "preparations of immune globulin or blood transfusion" ], "offsets": [ [ 72, 124 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T7", "type": "Temporal", "text": [ "more than 14 days" ], "offsets": [ [ 192, 209 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T8", "type": "Temporal", "text": [ "Prolonged use" ], "offsets": [ [ 177, 190 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T9", "type": "Drug", "text": [ "immunosuppressants" ], "offsets": [ [ 211, 229 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T10", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 233, 238 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T11", "type": "Drug", "text": [ "immunosuppressive drugs" ], "offsets": [ [ 239, 262 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T12", "type": "Temporal", "text": [ "within 6 months prior to the start of the study" ], "offsets": [ [ 263, 310 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T13", "type": "Scope", "text": [ "immunosuppressants or other immunosuppressive drugs" ], "offsets": [ [ 211, 262 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T14", "type": "Condition", "text": [ "unosuppressive or", "dition, i" ], "offsets": [ [ 342, 359 ], [ 379, 388 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T15", "type": "Condition", "text": [ "immunodeficient condition" ], "offsets": [ [ 360, 385 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T16", "type": "Condition", "text": [ "HIV infection" ], "offsets": [ [ 397, 410 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T17", "type": "Scope", "text": [ "immunosuppressive or immunodeficient condition" ], "offsets": [ [ 339, 385 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T19", "type": "Measurement", "text": [ "reaction for HIV infection" ], "offsets": [ [ 477, 503 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T20", "type": "Value", "text": [ "positive" ], "offsets": [ [ 468, 476 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T21", "type": "Measurement", "text": [ "ion for HIV", " hepatitis B an" ], "offsets": [ [ 482, 493 ], [ 510, 525 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T22", "type": "Measurement", "text": [ "ion for HIV", "itis C;\nThe" ], "offsets": [ [ 482, 493 ], [ 532, 543 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T23", "type": "Scope", "text": [ "reaction for HIV infection, viral hepatitis B and hepatitis C" ], "offsets": [ [ 477, 538 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T24", "type": "Condition", "text": [ "cardio-vascular insufficiency" ], "offsets": [ [ 569, 598 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T25", "type": "Condition", "text": [ "atory, card", "iciency, impa" ], "offsets": [ [ 562, 573 ], [ 591, 604 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T26", "type": "Condition", "text": [ "impaired liver" ], "offsets": [ [ 600, 614 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T27", "type": "Condition", "text": [ "ed liver", " function, est" ], "offsets": [ [ 606, 614 ], [ 625, 639 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T28", "type": "Temporal", "text": [ "at visit number 1" ], "offsets": [ [ 678, 695 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T29", "type": "Scope", "text": [ "respiratory, cardio-vascular insufficiency, impaired liver and kidney function" ], "offsets": [ [ 556, 634 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T30", "type": "Condition", "text": [ "congenital defects" ], "offsets": [ [ 708, 726 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T31", "type": "Condition", "text": [ "chronic diseases" ], "offsets": [ [ 738, 754 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T32", "type": "Qualifier", "text": [ "acute stage" ], "offsets": [ [ 762, 773 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T33", "type": "Qualifier", "text": [ "clinically important" ], "offsets": [ [ 789, 809 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T34", "type": "Qualifier", "text": [ "serious" ], "offsets": [ [ 730, 737 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T35", "type": "Condition", "text": [ "exacerbation" ], "offsets": [ [ 810, 822 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T36", "type": "Condition", "text": [ "diseases of the liver" ], "offsets": [ [ 834, 855 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T37", "type": "Qualifier", "text": [ "chronic" ], "offsets": [ [ 826, 833 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T38", "type": "Condition", "text": [ "s of the liver,", " card" ], "offsets": [ [ 841, 856 ], [ 864, 869 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T39", "type": "Condition", "text": [ "s of the liver,", "ascular, nervo", " ment" ], "offsets": [ [ 841, 856 ], [ 872, 886 ], [ 896, 901 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T40", "type": "Condition", "text": [ "s of the liver,", " system, ment" ], "offsets": [ [ 841, 856 ], [ 888, 901 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T41", "type": "Condition", "text": [ "mental diseases" ], "offsets": [ [ 897, 912 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T42", "type": "Condition", "text": [ "metabolic disorders" ], "offsets": [ [ 916, 935 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T43", "type": "Condition", "text": [ "cystic fibrosis" ], "offsets": [ [ 999, 1014 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T44", "type": "Condition", "text": [ "lung abscess" ], "offsets": [ [ 1016, 1028 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T45", "type": "Condition", "text": [ "empyema" ], "offsets": [ [ 1030, 1037 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T46", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 1039, 1045 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T47", "type": "Condition", "text": [ "tuberculosis" ], "offsets": [ [ 1046, 1058 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T48", "type": "Condition", "text": [ "congestive heart failure" ], "offsets": [ [ 1077, 1101 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T49", "type": "Condition", "text": [ "malabsorption" ], "offsets": [ [ 1103, 1116 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T50", "type": "Condition", "text": [ "hepatic failure" ], "offsets": [ [ 1136, 1151 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T51", "type": "Condition", "text": [ "nd he", ", cirrh" ], "offsets": [ [ 1133, 1138 ], [ 1151, 1158 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T52", "type": "Qualifier", "text": [ "chronic" ], "offsets": [ [ 1118, 1125 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T53", "type": "Scope", "text": [ "renal and hepatic failure" ], "offsets": [ [ 1126, 1151 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T54", "type": "Condition", "text": [ "cirrhosis" ], "offsets": [ [ 1153, 1162 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T55", "type": "Condition", "text": [ "malignancy" ], "offsets": [ [ 1164, 1174 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T56", "type": "Condition", "text": [ "immunodeficiency" ], "offsets": [ [ 1176, 1192 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T57", "type": "Condition", "text": [ "cirrhosis of the liver" ], "offsets": [ [ 1194, 1216 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T58", "type": "Scope", "text": [ "pulmonary: cystic fibrosis, lung abscess, empyema, active tuberculosis; extra-pulmonary: congestive heart failure, malabsorption, chronic renal and hepatic failure, cirrhosis, malignancy, immunodeficiency, cirrhosis of the liver" ], "offsets": [ [ 988, 1216 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T59", "type": "Scope", "text": [ "diseases of the liver, kidney, cardiovascular, nervous system" ], "offsets": [ [ 834, 895 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T60", "type": "Scope", "text": [ "exacerbation of chronic diseases of the liver, kidney, cardiovascular, nervous system, mental diseases or metabolic disorders" ], "offsets": [ [ 810, 935 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T61", "type": "Scope", "text": [ "congenital defects or serious chronic diseases in the acute stage" ], "offsets": [ [ 708, 773 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T62", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 1219, 1225 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T63", "type": "Condition", "text": [ "allergic reactions" ], "offsets": [ [ 1226, 1244 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T64", "type": "Qualifier", "text": [ "acute" ], "offsets": [ [ 1297, 1302 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T65", "type": "Condition", "text": [ "s and/or c", " within " ], "offsets": [ [ 1312, 1322 ], [ 1343, 1351 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T66", "type": "Condition", "text": [ "communicable illnesses" ], "offsets": [ [ 1321, 1343 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T67", "type": "Temporal", "text": [ "within 1 month prior to study" ], "offsets": [ [ 1344, 1373 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T68", "type": "Scope", "text": [ "infectious and/or communicable illnesses" ], "offsets": [ [ 1303, 1343 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T69", "type": "Condition", "text": [ "alcohol abuse" ], "offsets": [ [ 1394, 1407 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T70", "type": "Condition", "text": [ "drug use" ], "offsets": [ [ 1415, 1423 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T71", "type": "Qualifier", "text": [ "chronic" ], "offsets": [ [ 1386, 1393 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T72", "type": "Scope", "text": [ "alcohol abuse and/or drug use" ], "offsets": [ [ 1394, 1423 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T73", "type": "Condition", "text": [ "Exacerbation" ], "offsets": [ [ 1425, 1437 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T74", "type": "Condition", "text": [ "chronic diseases" ], "offsets": [ [ 1441, 1457 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T75", "type": "Observation", "text": [ "Breastfeeding" ], "offsets": [ [ 1459, 1472 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T76", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 1474, 1483 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T77", "type": "Observation", "text": [ "in any other cli", " within the l" ], "offsets": [ [ 1499, 1515 ], [ 1526, 1539 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T78", "type": "Qualifier", "text": [ "any other" ], "offsets": [ [ 1502, 1511 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T79", "type": "Temporal", "text": [ "within the last 3 months" ], "offsets": [ [ 1527, 1551 ] ], "normalized": [] }, { "id": "NCT02787863_exc_T80", "type": "Reference_point", "text": [ "study" ], "offsets": [ [ 1368, 1373 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02787863_exc_R1", "type": "AND", "arg1_id": "NCT02787863_exc_T2", "arg2_id": "NCT02787863_exc_T1", "normalized": [] }, { "id": "NCT02787863_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02787863_exc_T6", "arg2_id": "NCT02787863_exc_T5", "normalized": [] }, { "id": "NCT02787863_exc_R3", "type": "Subsumes", "arg1_id": "NCT02787863_exc_T8", "arg2_id": "NCT02787863_exc_T7", "normalized": [] }, { "id": "NCT02787863_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT02787863_exc_T11", "arg2_id": "NCT02787863_exc_T10", "normalized": [] }, { "id": "NCT02787863_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02787863_exc_T13", "arg2_id": "NCT02787863_exc_T8", "normalized": [] }, { "id": "NCT02787863_exc_R6", "type": "Has_temporal", "arg1_id": "NCT02787863_exc_T13", "arg2_id": "NCT02787863_exc_T12", "normalized": [] }, { "id": "NCT02787863_exc_R7", "type": "Subsumes", "arg1_id": "NCT02787863_exc_T17", "arg2_id": "NCT02787863_exc_T16", "normalized": [] }, { "id": "NCT02787863_exc_R8", "type": "Has_value", "arg1_id": "NCT02787863_exc_T23", "arg2_id": "NCT02787863_exc_T20", "normalized": [] }, { "id": "NCT02787863_exc_R9", "type": "Has_temporal", "arg1_id": "NCT02787863_exc_T29", "arg2_id": "NCT02787863_exc_T28", "normalized": [] }, { "id": "NCT02787863_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT02787863_exc_T31", "arg2_id": "NCT02787863_exc_T32", "normalized": [] }, { "id": "NCT02787863_exc_R11", "type": "Has_qualifier", "arg1_id": "NCT02787863_exc_T31", "arg2_id": "NCT02787863_exc_T34", "normalized": [] }, { "id": "NCT02787863_exc_R12", "type": "Has_qualifier", "arg1_id": "NCT02787863_exc_T47", "arg2_id": "NCT02787863_exc_T46", "normalized": [] }, { "id": "NCT02787863_exc_R13", "type": "Has_qualifier", "arg1_id": "NCT02787863_exc_T53", "arg2_id": "NCT02787863_exc_T52", "normalized": [] }, { "id": "NCT02787863_exc_R14", "type": "Has_qualifier", "arg1_id": "NCT02787863_exc_T59", "arg2_id": "NCT02787863_exc_T37", "normalized": [] }, { "id": "NCT02787863_exc_R15", "type": "Has_qualifier", "arg1_id": "NCT02787863_exc_T60", "arg2_id": "NCT02787863_exc_T33", "normalized": [] }, { "id": "NCT02787863_exc_R16", "type": "Subsumes", "arg1_id": "NCT02787863_exc_T59", "arg2_id": "NCT02787863_exc_T58", "normalized": [] }, { "id": "NCT02787863_exc_R17", "type": "Subsumes", "arg1_id": "NCT02787863_exc_T61", "arg2_id": "NCT02787863_exc_T59", "normalized": [] }, { "id": "NCT02787863_exc_R18", "type": "Has_qualifier", "arg1_id": "NCT02787863_exc_T63", "arg2_id": "NCT02787863_exc_T62", "normalized": [] }, { "id": "NCT02787863_exc_R19", "type": "Has_qualifier", "arg1_id": "NCT02787863_exc_T68", "arg2_id": "NCT02787863_exc_T64", "normalized": [] }, { "id": "NCT02787863_exc_R20", "type": "Has_temporal", "arg1_id": "NCT02787863_exc_T68", "arg2_id": "NCT02787863_exc_T67", "normalized": [] }, { "id": "NCT02787863_exc_R21", "type": "Has_qualifier", "arg1_id": "NCT02787863_exc_T72", "arg2_id": "NCT02787863_exc_T71", "normalized": [] }, { "id": "NCT02787863_exc_R22", "type": "AND", "arg1_id": "NCT02787863_exc_T73", "arg2_id": "NCT02787863_exc_T74", "normalized": [] }, { "id": "NCT02787863_exc_R23", "type": "Has_qualifier", "arg1_id": "NCT02787863_exc_T77", "arg2_id": "NCT02787863_exc_T78", "normalized": [] }, { "id": "NCT02787863_exc_R24", "type": "Has_temporal", "arg1_id": "NCT02787863_exc_T77", "arg2_id": "NCT02787863_exc_T79", "normalized": [] }, { "id": "NCT02787863_exc_R25", "type": "Has_index", "arg1_id": "NCT02787863_exc_T67", "arg2_id": "NCT02787863_exc_T80", "normalized": [] } ]

[ { "id": "NCT02787863_inc_text", "type": "inclusion", "text": [ "Individuals of both sexes from 18 years with a diagnosis of community-acquired pneumonia, COPD or Bronchial Asthma;\nThe presence of signed and dated informed consent to participate in a clinical study;\nThe ability to perform the requirements of the Protocol;\nFor women of childbearing age is a negative result of a pregnancy test before vaccination.\ncommunity-acquired pneumonia: the presence of radiologically confirmed infiltration of the lung tissue; the presence of at least two of the following clinical signs: acute fever early in the disease (temperature > 38.0°C), cough with sputum, the physical signs of pneumonia (focus of crepitate and/or fine bubble rales, bronchial breathing hard, shortening of percussion sounds), leukocytosis > 10*10 9 /l and/or stab shift > 10%; the occurrence of the disease outside the hospital and the organized groups (such as nursing homes, sanatoriums, etc.).\nCOPD: dyspnea: progressive (worsens over time), increases with exertion, persistent; chronic cough (may appear sporadically and may be unproductive); chronic expectoration; the impact of risk factors in the medical history (Smoking, occupational dust pollutants and chemicals); widespread wheeze on auscultation of the chest and/or distant wheezing in the chest; family history of COPD; spirometric data confirming the presence of fixed bronchial obstruction.\n" ], "offsets": [ [ 0, 1361 ] ] } ]

[ { "id": "NCT02787863_inc_T1", "type": "Person", "text": [ "both sexes" ], "offsets": [ [ 15, 25 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T2", "type": "Value", "text": [ "from 18 years" ], "offsets": [ [ 26, 39 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T3", "type": "Person", "text": [ "from 18 years" ], "offsets": [ [ 26, 39 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T4", "type": "Condition", "text": [ "community-acquired pneumonia" ], "offsets": [ [ 60, 88 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T5", "type": "Condition", "text": [ "COPD" ], "offsets": [ [ 90, 94 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T6", "type": "Condition", "text": [ "Bronchial Asthma" ], "offsets": [ [ 98, 114 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T10", "type": "Qualifier", "text": [ "radiologically confirmed" ], "offsets": [ [ 396, 420 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T11", "type": "Procedure", "text": [ "radiologically" ], "offsets": [ [ 396, 410 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T12", "type": "Condition", "text": [ "infiltration of the lung tissue" ], "offsets": [ [ 421, 452 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T13", "type": "Multiplier", "text": [ "at least two" ], "offsets": [ [ 470, 482 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T14", "type": "Condition", "text": [ "acute fever" ], "offsets": [ [ 516, 527 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T15", "type": "Temporal", "text": [ "early in the disease" ], "offsets": [ [ 528, 548 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T16", "type": "Measurement", "text": [ "temperature" ], "offsets": [ [ 550, 561 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T17", "type": "Value", "text": [ "> 38.0°C" ], "offsets": [ [ 562, 570 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T18", "type": "Condition", "text": [ "cough with sputum" ], "offsets": [ [ 573, 590 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T19", "type": "Condition", "text": [ "pneumonia" ], "offsets": [ [ 614, 623 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T20", "type": "Condition", "text": [ "physical signs" ], "offsets": [ [ 596, 610 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T21", "type": "Condition", "text": [ "itate and", "s, br" ], "offsets": [ [ 638, 647 ], [ 667, 672 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T22", "type": "Condition", "text": [ "fine bubble rales" ], "offsets": [ [ 651, 668 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T23", "type": "Condition", "text": [ "bronchial breathing hard" ], "offsets": [ [ 670, 694 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T24", "type": "Condition", "text": [ "shortening of percussion sounds" ], "offsets": [ [ 696, 727 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T25", "type": "Scope", "text": [ "crepitate and/or fine bubble rales, bronchial breathing hard, shortening of percussion sounds" ], "offsets": [ [ 634, 727 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T26", "type": "Scope", "text": [ "physical signs of pneumonia" ], "offsets": [ [ 596, 623 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T27", "type": "Measurement", "text": [ "leukocytosis" ], "offsets": [ [ 730, 742 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T28", "type": "Value", "text": [ "> 10*10 9 /l" ], "offsets": [ [ 743, 755 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T29", "type": "Measurement", "text": [ "stab shift" ], "offsets": [ [ 763, 773 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T30", "type": "Value", "text": [ "> 10%" ], "offsets": [ [ 774, 779 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T31", "type": "Scope", "text": [ "acute fever early in the disease (temperature > 38.0°C), cough with sputum, the physical signs of pneumonia (focus of crepitate and/or fine bubble rales, bronchial breathing hard, shortening of percussion sounds), leukocytosis > 10*10 9 /l and/or stab shift > 10%" ], "offsets": [ [ 516, 779 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T32", "type": "Condition", "text": [ "dyspnea" ], "offsets": [ [ 907, 914 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T33", "type": "Condition", "text": [ "community-acquired pneumonia" ], "offsets": [ [ 350, 378 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T34", "type": "Scope", "text": [ "radiologically confirmed infiltration of the lung tissue; the presence of at least two of the following clinical signs: acute fever early in the disease (temperature > 38.0°C), cough with sputum, the physical signs of pneumonia (focus of crepitate and/or fine bubble rales, bronchial breathing hard, shortening of percussion sounds), leukocytosis > 10*10 9 /l and/or stab shift > 10%" ], "offsets": [ [ 396, 779 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T35", "type": "Qualifier", "text": [ "progressive" ], "offsets": [ [ 916, 927 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T36", "type": "Qualifier", "text": [ "worsens over time" ], "offsets": [ [ 929, 946 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T37", "type": "Qualifier", "text": [ "increases with exertion" ], "offsets": [ [ 949, 972 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T38", "type": "Qualifier", "text": [ "persistent" ], "offsets": [ [ 974, 984 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T39", "type": "Condition", "text": [ "chronic cough" ], "offsets": [ [ 986, 999 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T40", "type": "Condition", "text": [ "chronic expectoration" ], "offsets": [ [ 1051, 1072 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T41", "type": "Condition", "text": [ "Smoking" ], "offsets": [ [ 1125, 1132 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T42", "type": "Condition", "text": [ "risk factors" ], "offsets": [ [ 1088, 1100 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T43", "type": "Condition", "text": [ "occupational dust pollutants and chemicals" ], "offsets": [ [ 1134, 1176 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T44", "type": "Condition", "text": [ "wheeze on auscultation of the chest" ], "offsets": [ [ 1190, 1225 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T45", "type": "Condition", "text": [ "distant wheezing in the chest" ], "offsets": [ [ 1233, 1262 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T46", "type": "Qualifier", "text": [ "widespread" ], "offsets": [ [ 1179, 1189 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T47", "type": "Observation", "text": [ "family history" ], "offsets": [ [ 1264, 1278 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T48", "type": "Condition", "text": [ "COPD" ], "offsets": [ [ 1282, 1286 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T49", "type": "Procedure", "text": [ "spirometric" ], "offsets": [ [ 1288, 1299 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T50", "type": "Condition", "text": [ "fixed bronchial obstruction" ], "offsets": [ [ 1332, 1359 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T51", "type": "Scope", "text": [ "Smoking, occupational dust pollutants and chemicals" ], "offsets": [ [ 1125, 1176 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T52", "type": "Scope", "text": [ "progressive (worsens over time), increases with exertion, persistent" ], "offsets": [ [ 916, 984 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T53", "type": "Condition", "text": [ "COPD" ], "offsets": [ [ 901, 905 ] ], "normalized": [] }, { "id": "NCT02787863_inc_T54", "type": "Scope", "text": [ "dyspnea: progressive (worsens over time), increases with exertion, persistent; chronic cough (may appear sporadically and may be unproductive); chronic expectoration; the impact of risk factors in the medical history (Smoking, occupational dust pollutants and chemicals); widespread wheeze on auscultation of the chest and/or distant wheezing in the chest; family history of COPD; spirometric data confirming the presence of fixed bronchial obstruction" ], "offsets": [ [ 907, 1359 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT02787863_inc_R1", "type": "Has_value", "arg1_id": "NCT02787863_inc_T3", "arg2_id": "NCT02787863_inc_T2", "normalized": [] }, { "id": "NCT02787863_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT02787863_inc_T12", "arg2_id": "NCT02787863_inc_T10", "normalized": [] }, { "id": "NCT02787863_inc_R4", "type": "Has_value", "arg1_id": "NCT02787863_inc_T16", "arg2_id": "NCT02787863_inc_T17", "normalized": [] }, { "id": "NCT02787863_inc_R5", "type": "Subsumes", "arg1_id": "NCT02787863_inc_T14", "arg2_id": "NCT02787863_inc_T16", "normalized": [] }, { "id": "NCT02787863_inc_R6", "type": "Has_temporal", "arg1_id": "NCT02787863_inc_T14", "arg2_id": "NCT02787863_inc_T15", "normalized": [] }, { "id": "NCT02787863_inc_R7", "type": "AND", "arg1_id": "NCT02787863_inc_T20", "arg2_id": "NCT02787863_inc_T19", "normalized": [] }, { "id": "NCT02787863_inc_R8", "type": "Subsumes", "arg1_id": "NCT02787863_inc_T26", "arg2_id": "NCT02787863_inc_T25", "normalized": [] }, { "id": "NCT02787863_inc_R9", "type": "Has_value", "arg1_id": "NCT02787863_inc_T29", "arg2_id": "NCT02787863_inc_T30", "normalized": [] }, { "id": "NCT02787863_inc_R10", "type": "Has_value", "arg1_id": "NCT02787863_inc_T27", "arg2_id": "NCT02787863_inc_T28", "normalized": [] }, { "id": "NCT02787863_inc_R11", "type": "Has_multiplier", "arg1_id": "NCT02787863_inc_T31", "arg2_id": "NCT02787863_inc_T13", "normalized": [] }, { "id": "NCT02787863_inc_R12", "type": "Subsumes", "arg1_id": "NCT02787863_inc_T33", "arg2_id": "NCT02787863_inc_T34", "normalized": [] }, { "id": "NCT02787863_inc_R13", "type": "Subsumes", "arg1_id": "NCT02787863_inc_T35", "arg2_id": "NCT02787863_inc_T36", "normalized": [] }, { "id": "NCT02787863_inc_R14", "type": "Has_qualifier", "arg1_id": "NCT02787863_inc_T44", "arg2_id": "NCT02787863_inc_T46", "normalized": [] }, { "id": "NCT02787863_inc_R16", "type": "AND", "arg1_id": "NCT02787863_inc_T49", "arg2_id": "NCT02787863_inc_T50", "normalized": [] }, { "id": "NCT02787863_inc_R17", "type": "Subsumes", "arg1_id": "NCT02787863_inc_T42", "arg2_id": "NCT02787863_inc_T51", "normalized": [] }, { "id": "NCT02787863_inc_R18", "type": "Has_scope", "arg1_id": "NCT02787863_inc_T32", "arg2_id": "NCT02787863_inc_T52", "normalized": [] }, { "id": "NCT02787863_inc_R19", "type": "Subsumes", "arg1_id": "NCT02787863_inc_T53", "arg2_id": "NCT02787863_inc_T54", "normalized": [] } ]

[ { "id": "NCT02788045_exc_text", "type": "exclusion", "text": [ "Has chronic hepatitis B (measured by hepatitis B surface antigen test) or active hepatitis C (measured by hepatitis C virus [HCV] Ab test; if positive, HCV ribonucleic acid [RNA] PCR test will be used to confirm active versus past HCV infection), active syphilis infection, chlamydia, gonorrhea, or trichomonas . Active syphilis documented by serology unless positive serology is due to past treated infection \nHas had a thyroidectomy or active thyroid disease requiring medication during the last 12 months (not excluded: a stable thyroid supplementation) \nHas had major psychiatric illness and/or substance abuse problems during the past 12 months (including hospitalization or periods of work disability) that in the opinion of the investigator would preclude participation \nHas been in receipt of any licensed vaccine within 14 days prior to the first dose of study vaccine/placebo, plans to receive within 14 days after the first study vaccination, or plans to receive within 14 days before or after the second, third or fourth vaccination \nIs a recipient of a prophylactic or therapeutic HIV vaccine candidate at any time, or a recipient of other experimental vaccine(s) within the last 12 months. For participants who received an experimental vaccine (except HIV vaccine) more than 12 months ago, documentation of the identity of the experimental vaccine must be provided to the sponsor, who will determine eligibility on a case-by-case basis \n \n" ], "offsets": [ [ 0, 1462 ] ] } ]

[ { "id": "NCT02788045_exc_T1", "type": "Condition", "text": [ "chronic hepatitis B" ], "offsets": [ [ 4, 23 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T2", "type": "Measurement", "text": [ "hepatitis B surface antigen test" ], "offsets": [ [ 37, 69 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T3", "type": "Condition", "text": [ "active hepatitis C" ], "offsets": [ [ 74, 92 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T4", "type": "Measurement", "text": [ "hepatitis C virus [HCV] Ab test" ], "offsets": [ [ 106, 137 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T5", "type": "Value", "text": [ "positive" ], "offsets": [ [ 142, 150 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T6", "type": "Measurement", "text": [ "HCV ribonucleic acid [RNA] PCR test" ], "offsets": [ [ 152, 187 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T7", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 247, 253 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T8", "type": "Condition", "text": [ "syphilis infection" ], "offsets": [ [ 254, 272 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T9", "type": "Condition", "text": [ "chlamydia" ], "offsets": [ [ 274, 283 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T10", "type": "Condition", "text": [ "gonorrhea" ], "offsets": [ [ 285, 294 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T11", "type": "Condition", "text": [ "trichomonas" ], "offsets": [ [ 299, 310 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T12", "type": "Qualifier", "text": [ "Active" ], "offsets": [ [ 313, 319 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T13", "type": "Condition", "text": [ "syphilis" ], "offsets": [ [ 320, 328 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T14", "type": "Measurement", "text": [ "serology" ], "offsets": [ [ 343, 351 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T15", "type": "Measurement", "text": [ "serology" ], "offsets": [ [ 368, 376 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T16", "type": "Value", "text": [ "positive" ], "offsets": [ [ 359, 367 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T19", "type": "Condition", "text": [ "treated infection" ], "offsets": [ [ 392, 409 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T20", "type": "Negation", "text": [ "unless" ], "offsets": [ [ 352, 358 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T21", "type": "Procedure", "text": [ "thyroidectomy" ], "offsets": [ [ 421, 434 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T22", "type": "Condition", "text": [ "thyroid disease" ], "offsets": [ [ 445, 460 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T23", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 438, 444 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T24", "type": "Drug", "text": [ "medication" ], "offsets": [ [ 471, 481 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T26", "type": "Temporal", "text": [ "during the last 12 months" ], "offsets": [ [ 482, 507 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T27", "type": "Drug", "text": [ "thyroid supplementation" ], "offsets": [ [ 532, 555 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T28", "type": "Qualifier", "text": [ "stable" ], "offsets": [ [ 525, 531 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T29", "type": "Condition", "text": [ "psychiatric illness" ], "offsets": [ [ 572, 591 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T30", "type": "Qualifier", "text": [ "major" ], "offsets": [ [ 566, 571 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T32", "type": "Condition", "text": [ "substance abuse" ], "offsets": [ [ 599, 614 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T33", "type": "Temporal", "text": [ "during the past 12 months" ], "offsets": [ [ 624, 649 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T34", "type": "Procedure", "text": [ "hospitalization" ], "offsets": [ [ 661, 676 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T35", "type": "Condition", "text": [ "work disability" ], "offsets": [ [ 691, 706 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T36", "type": "Scope", "text": [ "hospitalization or periods of work disability" ], "offsets": [ [ 661, 706 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T37", "type": "Scope", "text": [ "major psychiatric illness and/or substance abuse" ], "offsets": [ [ 566, 614 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T40", "type": "Drug", "text": [ "licensed vaccine" ], "offsets": [ [ 805, 821 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T41", "type": "Temporal", "text": [ "within 14 days prior" ], "offsets": [ [ 822, 842 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T42", "type": "Reference_point", "text": [ "the first dose of study vaccine/placebo" ], "offsets": [ [ 846, 885 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T43", "type": "Temporal", "text": [ "within 14 days after" ], "offsets": [ [ 904, 924 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T44", "type": "Reference_point", "text": [ "first study vaccination" ], "offsets": [ [ 929, 952 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T45", "type": "Drug", "text": [ "study vaccine" ], "offsets": [ [ 864, 877 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T46", "type": "Drug", "text": [ "placebo" ], "offsets": [ [ 878, 885 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T47", "type": "Procedure", "text": [ "study vaccination" ], "offsets": [ [ 935, 952 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T49", "type": "Temporal", "text": [ "within 14 days before or after" ], "offsets": [ [ 974, 1004 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T50", "type": "Reference_point", "text": [ "second, third or fourth vaccination" ], "offsets": [ [ 1009, 1044 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T51", "type": "Drug", "text": [ "vaccination" ], "offsets": [ [ 1033, 1044 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T53", "type": "Scope", "text": [ "within 14 days prior to the first dose of study vaccine/placebo, plans to receive within 14 days after the first study vaccination, or plans to receive within 14 days before or after the second, third or fourth vaccination" ], "offsets": [ [ 822, 1044 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T54", "type": "Drug", "text": [ "HIV vaccine candidate" ], "offsets": [ [ 1094, 1115 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T55", "type": "Temporal", "text": [ "at any time" ], "offsets": [ [ 1116, 1127 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T56", "type": "Drug", "text": [ "other experimental vaccine(s)" ], "offsets": [ [ 1147, 1176 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T58", "type": "Temporal", "text": [ "within the last 12 months" ], "offsets": [ [ 1177, 1202 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T59", "type": "Qualifier", "text": [ "therapeutic" ], "offsets": [ [ 1082, 1093 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T60", "type": "Qualifier", "text": [ "prophylactic" ], "offsets": [ [ 1066, 1078 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T61", "type": "Scope", "text": [ "prophylactic or therapeutic" ], "offsets": [ [ 1066, 1093 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T62", "type": "Drug", "text": [ "experimental vaccine" ], "offsets": [ [ 1237, 1257 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T63", "type": "Drug", "text": [ "HIV vaccine" ], "offsets": [ [ 1266, 1277 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T64", "type": "Negation", "text": [ "except" ], "offsets": [ [ 1259, 1265 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T65", "type": "Temporal", "text": [ "more than 12 months ago" ], "offsets": [ [ 1279, 1302 ] ], "normalized": [] }, { "id": "NCT02788045_exc_T17", "type": "Negation", "text": [ "not excluded" ], "offsets": [ [ 509, 521 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02788045_exc_R1", "type": "AND", "arg1_id": "NCT02788045_exc_T1", "arg2_id": "NCT02788045_exc_T2", "normalized": [] }, { "id": "NCT02788045_exc_R2", "type": "AND", "arg1_id": "NCT02788045_exc_T5", "arg2_id": "NCT02788045_exc_T6", "normalized": [] }, { "id": "NCT02788045_exc_R3", "type": "Has_value", "arg1_id": "NCT02788045_exc_T4", "arg2_id": "NCT02788045_exc_T5", "normalized": [] }, { "id": "NCT02788045_exc_R4", "type": "AND", "arg1_id": "NCT02788045_exc_T3", "arg2_id": "NCT02788045_exc_T4", "normalized": [] }, { "id": "NCT02788045_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02788045_exc_T8", "arg2_id": "NCT02788045_exc_T7", "normalized": [] }, { "id": "NCT02788045_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02788045_exc_T13", "arg2_id": "NCT02788045_exc_T12", "normalized": [] }, { "id": "NCT02788045_exc_R7", "type": "AND", "arg1_id": "NCT02788045_exc_T13", "arg2_id": "NCT02788045_exc_T14", "normalized": [] }, { "id": "NCT02788045_exc_R8", "type": "Has_value", "arg1_id": "NCT02788045_exc_T15", "arg2_id": "NCT02788045_exc_T16", "normalized": [] }, { "id": "NCT02788045_exc_R9", "type": "AND", "arg1_id": "NCT02788045_exc_T16", "arg2_id": "NCT02788045_exc_T19", "normalized": [] }, { "id": "NCT02788045_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT02788045_exc_T22", "arg2_id": "NCT02788045_exc_T23", "normalized": [] }, { "id": "NCT02788045_exc_R11", "type": "Has_qualifier", "arg1_id": "NCT02788045_exc_T27", "arg2_id": "NCT02788045_exc_T28", "normalized": [] }, { "id": "NCT02788045_exc_R12", "type": "AND", "arg1_id": "NCT02788045_exc_T22", "arg2_id": "NCT02788045_exc_T24", "normalized": [] }, { "id": "NCT02788045_exc_R13", "type": "Has_temporal", "arg1_id": "NCT02788045_exc_T24", "arg2_id": "NCT02788045_exc_T26", "normalized": [] }, { "id": "NCT02788045_exc_R16", "type": "Has_qualifier", "arg1_id": "NCT02788045_exc_T29", "arg2_id": "NCT02788045_exc_T30", "normalized": [] }, { "id": "NCT02788045_exc_R17", "type": "Subsumes", "arg1_id": "NCT02788045_exc_T37", "arg2_id": "NCT02788045_exc_T36", "normalized": [] }, { "id": "NCT02788045_exc_R15", "type": "Has_temporal", "arg1_id": "NCT02788045_exc_T37", "arg2_id": "NCT02788045_exc_T33", "normalized": [] }, { "id": "NCT02788045_exc_R18", "type": "Has_index", "arg1_id": "NCT02788045_exc_T41", "arg2_id": "NCT02788045_exc_T42", "normalized": [] }, { "id": "NCT02788045_exc_R20", "type": "Has_index", "arg1_id": "NCT02788045_exc_T49", "arg2_id": "NCT02788045_exc_T50", "normalized": [] }, { "id": "NCT02788045_exc_R19", "type": "Has_scope", "arg1_id": "NCT02788045_exc_T40", "arg2_id": "NCT02788045_exc_T53", "normalized": [] }, { "id": "NCT02788045_exc_R21", "type": "Has_scope", "arg1_id": "NCT02788045_exc_T54", "arg2_id": "NCT02788045_exc_T61", "normalized": [] }, { "id": "NCT02788045_exc_R22", "type": "Has_temporal", "arg1_id": "NCT02788045_exc_T54", "arg2_id": "NCT02788045_exc_T55", "normalized": [] }, { "id": "NCT02788045_exc_R23", "type": "Has_temporal", "arg1_id": "NCT02788045_exc_T56", "arg2_id": "NCT02788045_exc_T58", "normalized": [] }, { "id": "NCT02788045_exc_R24", "type": "Has_negation", "arg1_id": "NCT02788045_exc_T63", "arg2_id": "NCT02788045_exc_T64", "normalized": [] }, { "id": "NCT02788045_exc_R25", "type": "AND", "arg1_id": "NCT02788045_exc_T62", "arg2_id": "NCT02788045_exc_T63", "normalized": [] }, { "id": "NCT02788045_exc_R26", "type": "Has_temporal", "arg1_id": "NCT02788045_exc_T62", "arg2_id": "NCT02788045_exc_T65", "normalized": [] }, { "id": "NCT02788045_exc_R27", "type": "Has_negation", "arg1_id": "NCT02788045_exc_T15", "arg2_id": "NCT02788045_exc_T20", "normalized": [] }, { "id": "NCT02788045_exc_R14", "type": "Has_negation", "arg1_id": "NCT02788045_exc_T27", "arg2_id": "NCT02788045_exc_T17", "normalized": [] }, { "id": "NCT02788045_exc_R28", "type": "AND", "arg1_id": "NCT02788045_exc_T22", "arg2_id": "NCT02788045_exc_T27", "normalized": [] } ]

[ { "id": "NCT02788045_inc_text", "type": "inclusion", "text": [ "Are negative for human immunodeficiency virus (HIV) infection at screening \nIs healthy on the basis of physical examination, medical history, electrocardiogram (ECG), and vital signs measurement performed at screening \nAre willing/able to adhere to the prohibitions and restrictions specified in the protocol and study procedures \nFemale participants of childbearing potential must have a negative serum pregnancy test (beta human chorionic gonadotropin [beta hCG]) at the Screening visit, and a negative urine pregnancy test pre-dose on Day 1 \nAre assessed by the clinic staff as being at low risk for HIV infection \n" ], "offsets": [ [ 0, 618 ] ] } ]

[ { "id": "NCT02788045_inc_T1", "type": "Condition", "text": [ "human immunodeficiency virus (HIV)" ], "offsets": [ [ 17, 51 ] ], "normalized": [] }, { "id": "NCT02788045_inc_T2", "type": "Negation", "text": [ "negative" ], "offsets": [ [ 4, 12 ] ], "normalized": [] }, { "id": "NCT02788045_inc_T3", "type": "Temporal", "text": [ "at screening" ], "offsets": [ [ 62, 74 ] ], "normalized": [] }, { "id": "NCT02788045_inc_T4", "type": "Condition", "text": [ "healthy" ], "offsets": [ [ 79, 86 ] ], "normalized": [] }, { "id": "NCT02788045_inc_T5", "type": "Procedure", "text": [ "electrocardiogram (ECG)" ], "offsets": [ [ 142, 165 ] ], "normalized": [] }, { "id": "NCT02788045_inc_T6", "type": "Observation", "text": [ "medical history" ], "offsets": [ [ 125, 140 ] ], "normalized": [] }, { "id": "NCT02788045_inc_T7", "type": "Procedure", "text": [ "physical examination" ], "offsets": [ [ 103, 123 ] ], "normalized": [] }, { "id": "NCT02788045_inc_T8", "type": "Procedure", "text": [ "vital signs measurement" ], "offsets": [ [ 171, 194 ] ], "normalized": [] }, { "id": "NCT02788045_inc_T9", "type": "Temporal", "text": [ "at screening" ], "offsets": [ [ 205, 217 ] ], "normalized": [] }, { "id": "NCT02788045_inc_T10", "type": "Scope", "text": [ "physical examination, medical history, electrocardiogram (ECG), and vital signs measurement" ], "offsets": [ [ 103, 194 ] ], "normalized": [] }, { "id": "NCT02788045_inc_T13", "type": "Person", "text": [ "Female" ], "offsets": [ [ 331, 337 ] ], "normalized": [] }, { "id": "NCT02788045_inc_T14", "type": "Condition", "text": [ "childbearing potential" ], "offsets": [ [ 354, 376 ] ], "normalized": [] }, { "id": "NCT02788045_inc_T15", "type": "Measurement", "text": [ "serum pregnancy test" ], "offsets": [ [ 398, 418 ] ], "normalized": [] }, { "id": "NCT02788045_inc_T16", "type": "Value", "text": [ "negative" ], "offsets": [ [ 389, 397 ] ], "normalized": [] }, { "id": "NCT02788045_inc_T17", "type": "Measurement", "text": [ "beta human chorionic gonadotropin [beta hCG]" ], "offsets": [ [ 420, 464 ] ], "normalized": [] }, { "id": "NCT02788045_inc_T18", "type": "Scope", "text": [ "serum pregnancy test (beta human chorionic gonadotropin [beta hCG])" ], "offsets": [ [ 398, 465 ] ], "normalized": [] }, { "id": "NCT02788045_inc_T19", "type": "Temporal", "text": [ "at the Screening visit" ], "offsets": [ [ 466, 488 ] ], "normalized": [] }, { "id": "NCT02788045_inc_T20", "type": "Reference_point", "text": [ "Screening visit" ], "offsets": [ [ 473, 488 ] ], "normalized": [] }, { "id": "NCT02788045_inc_T21", "type": "Measurement", "text": [ "urine pregnancy test" ], "offsets": [ [ 505, 525 ] ], "normalized": [] }, { "id": "NCT02788045_inc_T22", "type": "Value", "text": [ "negative" ], "offsets": [ [ 496, 504 ] ], "normalized": [] }, { "id": "NCT02788045_inc_T23", "type": "Temporal", "text": [ "pre-dose on Day 1" ], "offsets": [ [ 526, 543 ] ], "normalized": [] }, { "id": "NCT02788045_inc_T24", "type": "Reference_point", "text": [ "Day 1" ], "offsets": [ [ 538, 543 ] ], "normalized": [] }, { "id": "NCT02788045_inc_T26", "type": "Condition", "text": [ "low risk" ], "offsets": [ [ 590, 598 ] ], "normalized": [] }, { "id": "NCT02788045_inc_T27", "type": "Condition", "text": [ "HIV infection" ], "offsets": [ [ 603, 616 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02788045_inc_R1", "type": "Has_negation", "arg1_id": "NCT02788045_inc_T1", "arg2_id": "NCT02788045_inc_T2", "normalized": [] }, { "id": "NCT02788045_inc_R2", "type": "Has_temporal", "arg1_id": "NCT02788045_inc_T1", "arg2_id": "NCT02788045_inc_T3", "normalized": [] }, { "id": "NCT02788045_inc_R3", "type": "Has_scope", "arg1_id": "NCT02788045_inc_T4", "arg2_id": "NCT02788045_inc_T10", "normalized": [] }, { "id": "NCT02788045_inc_R4", "type": "Has_temporal", "arg1_id": "NCT02788045_inc_T10", "arg2_id": "NCT02788045_inc_T9", "normalized": [] }, { "id": "NCT02788045_inc_R5", "type": "Subsumes", "arg1_id": "NCT02788045_inc_T15", "arg2_id": "NCT02788045_inc_T17", "normalized": [] }, { "id": "NCT02788045_inc_R6", "type": "Has_value", "arg1_id": "NCT02788045_inc_T18", "arg2_id": "NCT02788045_inc_T16", "normalized": [] }, { "id": "NCT02788045_inc_R7", "type": "Has_scope", "arg1_id": "NCT02788045_inc_T14", "arg2_id": "NCT02788045_inc_T18", "normalized": [] }, { "id": "NCT02788045_inc_R8", "type": "AND", "arg1_id": "NCT02788045_inc_T13", "arg2_id": "NCT02788045_inc_T14", "normalized": [] }, { "id": "NCT02788045_inc_R9", "type": "Has_index", "arg1_id": "NCT02788045_inc_T19", "arg2_id": "NCT02788045_inc_T20", "normalized": [] }, { "id": "NCT02788045_inc_R10", "type": "Has_value", "arg1_id": "NCT02788045_inc_T21", "arg2_id": "NCT02788045_inc_T22", "normalized": [] }, { "id": "NCT02788045_inc_R11", "type": "Has_index", "arg1_id": "NCT02788045_inc_T23", "arg2_id": "NCT02788045_inc_T24", "normalized": [] }, { "id": "NCT02788045_inc_R12", "type": "Has_temporal", "arg1_id": "NCT02788045_inc_T21", "arg2_id": "NCT02788045_inc_T23", "normalized": [] }, { "id": "NCT02788045_inc_R13", "type": "Has_temporal", "arg1_id": "NCT02788045_inc_T18", "arg2_id": "NCT02788045_inc_T19", "normalized": [] }, { "id": "NCT02788045_inc_R14", "type": "AND", "arg1_id": "NCT02788045_inc_T13", "arg2_id": "NCT02788045_inc_T21", "normalized": [] }, { "id": "NCT02788045_inc_R15", "type": "AND", "arg1_id": "NCT02788045_inc_T27", "arg2_id": "NCT02788045_inc_T26", "normalized": [] } ]

[ { "id": "NCT02789111_exc_text", "type": "exclusion", "text": [ "More than three doses of any opioid within one week of surgery\nPregnancy\nPrisoners\nUnable to provide consent\nEmergency surgery\nChronic kidney disease stage 5 (GFR < 15 ml/min)\nSevere hepatic impairment\nRecent myocardial infarction (within the last 3 months)\n" ], "offsets": [ [ 0, 258 ] ] } ]

[ { "id": "NCT02789111_exc_T1", "type": "Multiplier", "text": [ "More than three doses" ], "offsets": [ [ 0, 21 ] ], "normalized": [] }, { "id": "NCT02789111_exc_T2", "type": "Drug", "text": [ "opioid" ], "offsets": [ [ 29, 35 ] ], "normalized": [] }, { "id": "NCT02789111_exc_T3", "type": "Temporal", "text": [ "within one week of surgery" ], "offsets": [ [ 36, 62 ] ], "normalized": [] }, { "id": "NCT02789111_exc_T4", "type": "Reference_point", "text": [ "surgery" ], "offsets": [ [ 55, 62 ] ], "normalized": [] }, { "id": "NCT02789111_exc_T5", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 63, 72 ] ], "normalized": [] }, { "id": "NCT02789111_exc_T6", "type": "Person", "text": [ "Prisoners" ], "offsets": [ [ 73, 82 ] ], "normalized": [] }, { "id": "NCT02789111_exc_T8", "type": "Procedure", "text": [ "Emergency surgery" ], "offsets": [ [ 109, 126 ] ], "normalized": [] }, { "id": "NCT02789111_exc_T9", "type": "Condition", "text": [ "Chronic kidney disease" ], "offsets": [ [ 127, 149 ] ], "normalized": [] }, { "id": "NCT02789111_exc_T10", "type": "Qualifier", "text": [ "stage 5" ], "offsets": [ [ 150, 157 ] ], "normalized": [] }, { "id": "NCT02789111_exc_T11", "type": "Measurement", "text": [ "GFR" ], "offsets": [ [ 159, 162 ] ], "normalized": [] }, { "id": "NCT02789111_exc_T12", "type": "Value", "text": [ "< 15 ml/min)" ], "offsets": [ [ 163, 175 ] ], "normalized": [] }, { "id": "NCT02789111_exc_T13", "type": "Condition", "text": [ "hepatic impairment" ], "offsets": [ [ 183, 201 ] ], "normalized": [] }, { "id": "NCT02789111_exc_T14", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 176, 182 ] ], "normalized": [] }, { "id": "NCT02789111_exc_T15", "type": "Condition", "text": [ "myocardial infarction" ], "offsets": [ [ 209, 230 ] ], "normalized": [] }, { "id": "NCT02789111_exc_T16", "type": "Temporal", "text": [ "the last 3 months" ], "offsets": [ [ 239, 256 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02789111_exc_R1", "type": "Has_multiplier", "arg1_id": "NCT02789111_exc_T2", "arg2_id": "NCT02789111_exc_T1", "normalized": [] }, { "id": "NCT02789111_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02789111_exc_T2", "arg2_id": "NCT02789111_exc_T3", "normalized": [] }, { "id": "NCT02789111_exc_R3", "type": "Has_index", "arg1_id": "NCT02789111_exc_T3", "arg2_id": "NCT02789111_exc_T4", "normalized": [] }, { "id": "NCT02789111_exc_R4", "type": "Has_value", "arg1_id": "NCT02789111_exc_T11", "arg2_id": "NCT02789111_exc_T12", "normalized": [] }, { "id": "NCT02789111_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02789111_exc_T9", "arg2_id": "NCT02789111_exc_T10", "normalized": [] }, { "id": "NCT02789111_exc_R6", "type": "Subsumes", "arg1_id": "NCT02789111_exc_T9", "arg2_id": "NCT02789111_exc_T11", "normalized": [] }, { "id": "NCT02789111_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT02789111_exc_T13", "arg2_id": "NCT02789111_exc_T14", "normalized": [] }, { "id": "NCT02789111_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02789111_exc_T15", "arg2_id": "NCT02789111_exc_T16", "normalized": [] } ]

[ { "id": "NCT02789111_inc_text", "type": "inclusion", "text": [ "Major spine surgery scheduled as part of clinical care\n18-80 years\n" ], "offsets": [ [ 0, 67 ] ] } ]

[ { "id": "NCT02789111_inc_T1", "type": "Procedure", "text": [ "Major spine surgery" ], "offsets": [ [ 0, 19 ] ], "normalized": [] }, { "id": "NCT02789111_inc_T2", "type": "Person", "text": [ "years" ], "offsets": [ [ 61, 66 ] ], "normalized": [] }, { "id": "NCT02789111_inc_T3", "type": "Value", "text": [ "18-80" ], "offsets": [ [ 55, 60 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02789111_inc_R1", "type": "Has_value", "arg1_id": "NCT02789111_inc_T2", "arg2_id": "NCT02789111_inc_T3", "normalized": [] } ]

[ { "id": "NCT02790593_exc_text", "type": "exclusion", "text": [ "Age less than 18 years\nSignificant arterial disease (Ankle Brachial Pressure Index <0•9 or evidence on Arterial Duplex)\nAcute Deep Vein Thrombosis\nPatient unable or unwilling to have high compression (30mmHg minimum)\nPatients with dexterity insufficiency of hands\nPatients with peripheral neuropathy\nLeg ulcers of another underlying cause\nLeg ulcers of greater than 1 year duration\nPatients unable or unwilling to provide written, informed consent\n" ], "offsets": [ [ 0, 448 ] ] } ]

[ { "id": "NCT02790593_exc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02790593_exc_T2", "type": "Value", "text": [ "less than 18 year" ], "offsets": [ [ 4, 21 ] ], "normalized": [] }, { "id": "NCT02790593_exc_T3", "type": "Condition", "text": [ "arterial disease" ], "offsets": [ [ 35, 51 ] ], "normalized": [] }, { "id": "NCT02790593_exc_T4", "type": "Qualifier", "text": [ "Significant" ], "offsets": [ [ 23, 34 ] ], "normalized": [] }, { "id": "NCT02790593_exc_T5", "type": "Measurement", "text": [ "Ankle Brachial Pressure Index" ], "offsets": [ [ 53, 82 ] ], "normalized": [] }, { "id": "NCT02790593_exc_T6", "type": "Value", "text": [ "<0•9" ], "offsets": [ [ 83, 87 ] ], "normalized": [] }, { "id": "NCT02790593_exc_T7", "type": "Procedure", "text": [ "Arterial Duplex" ], "offsets": [ [ 103, 118 ] ], "normalized": [] }, { "id": "NCT02790593_exc_T8", "type": "Condition", "text": [ "Acute Deep Vein Thrombosis" ], "offsets": [ [ 120, 146 ] ], "normalized": [] }, { "id": "NCT02790593_exc_T10", "type": "Condition", "text": [ "dexterity insufficiency of hands" ], "offsets": [ [ 231, 263 ] ], "normalized": [] }, { "id": "NCT02790593_exc_T11", "type": "Condition", "text": [ "peripheral neuropathy" ], "offsets": [ [ 278, 299 ] ], "normalized": [] }, { "id": "NCT02790593_exc_T12", "type": "Condition", "text": [ "Leg ulcers" ], "offsets": [ [ 300, 310 ] ], "normalized": [] }, { "id": "NCT02790593_exc_T13", "type": "Condition", "text": [ "underlying cause" ], "offsets": [ [ 322, 338 ] ], "normalized": [] }, { "id": "NCT02790593_exc_T14", "type": "Qualifier", "text": [ "another" ], "offsets": [ [ 314, 321 ] ], "normalized": [] }, { "id": "NCT02790593_exc_T15", "type": "Condition", "text": [ "Leg ulcers" ], "offsets": [ [ 339, 349 ] ], "normalized": [] }, { "id": "NCT02790593_exc_T16", "type": "Temporal", "text": [ "greater than 1 year duration" ], "offsets": [ [ 353, 381 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02790593_exc_R1", "type": "Has_value", "arg1_id": "NCT02790593_exc_T1", "arg2_id": "NCT02790593_exc_T2", "normalized": [] }, { "id": "NCT02790593_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02790593_exc_T3", "arg2_id": "NCT02790593_exc_T4", "normalized": [] }, { "id": "NCT02790593_exc_R3", "type": "AND", "arg1_id": "NCT02790593_exc_T7", "arg2_id": "NCT02790593_exc_T3", "normalized": [] }, { "id": "NCT02790593_exc_R4", "type": "Has_value", "arg1_id": "NCT02790593_exc_T5", "arg2_id": "NCT02790593_exc_T6", "normalized": [] }, { "id": "NCT02790593_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02790593_exc_T13", "arg2_id": "NCT02790593_exc_T14", "normalized": [] }, { "id": "NCT02790593_exc_R6", "type": "AND", "arg1_id": "NCT02790593_exc_T12", "arg2_id": "NCT02790593_exc_T13", "normalized": [] }, { "id": "NCT02790593_exc_R7", "type": "Has_temporal", "arg1_id": "NCT02790593_exc_T15", "arg2_id": "NCT02790593_exc_T16", "normalized": [] } ]

[ { "id": "NCT02790593_inc_text", "type": "inclusion", "text": [ "Age >18 years old\n1cm squared surface area\nVenous incompetence confirmed by clinical assessment and duplex ultrasound scan\nNo evidence of arterial disease (Arterial Duplex or Ankle Brachial Pressure Index >0.9)\nPatients able to complete trial procedures\nPatients with a life expectancy of greater than 1 year\n" ], "offsets": [ [ 0, 309 ] ] } ]

[ { "id": "NCT02790593_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02790593_inc_T2", "type": "Value", "text": [ ">18 years old" ], "offsets": [ [ 4, 17 ] ], "normalized": [] }, { "id": "NCT02790593_inc_T3", "type": "Measurement", "text": [ "surface area" ], "offsets": [ [ 30, 42 ] ], "normalized": [] }, { "id": "NCT02790593_inc_T4", "type": "Value", "text": [ "1cm squared" ], "offsets": [ [ 18, 29 ] ], "normalized": [] }, { "id": "NCT02790593_inc_T5", "type": "Condition", "text": [ "Venous incompetence" ], "offsets": [ [ 43, 62 ] ], "normalized": [] }, { "id": "NCT02790593_inc_T6", "type": "Procedure", "text": [ "clinical assessment" ], "offsets": [ [ 76, 95 ] ], "normalized": [] }, { "id": "NCT02790593_inc_T7", "type": "Procedure", "text": [ "duplex ultrasound scan" ], "offsets": [ [ 100, 122 ] ], "normalized": [] }, { "id": "NCT02790593_inc_T8", "type": "Scope", "text": [ "clinical assessment and duplex ultrasound scan" ], "offsets": [ [ 76, 122 ] ], "normalized": [] }, { "id": "NCT02790593_inc_T9", "type": "Condition", "text": [ "arterial disease" ], "offsets": [ [ 138, 154 ] ], "normalized": [] }, { "id": "NCT02790593_inc_T10", "type": "Negation", "text": [ "No" ], "offsets": [ [ 123, 125 ] ], "normalized": [] }, { "id": "NCT02790593_inc_T11", "type": "Procedure", "text": [ "Arterial Duplex" ], "offsets": [ [ 156, 171 ] ], "normalized": [] }, { "id": "NCT02790593_inc_T12", "type": "Measurement", "text": [ "Ankle Brachial Pressure Index" ], "offsets": [ [ 175, 204 ] ], "normalized": [] }, { "id": "NCT02790593_inc_T13", "type": "Value", "text": [ ">0.9" ], "offsets": [ [ 205, 209 ] ], "normalized": [] }, { "id": "NCT02790593_inc_T14", "type": "Scope", "text": [ "Arterial Duplex or Ankle Brachial Pressure Index >0.9" ], "offsets": [ [ 156, 209 ] ], "normalized": [] }, { "id": "NCT02790593_inc_T16", "type": "Observation", "text": [ "life expectancy" ], "offsets": [ [ 270, 285 ] ], "normalized": [] }, { "id": "NCT02790593_inc_T17", "type": "Value", "text": [ "greater than 1 year" ], "offsets": [ [ 289, 308 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02790593_inc_R1", "type": "Has_value", "arg1_id": "NCT02790593_inc_T1", "arg2_id": "NCT02790593_inc_T2", "normalized": [] }, { "id": "NCT02790593_inc_R2", "type": "Has_value", "arg1_id": "NCT02790593_inc_T3", "arg2_id": "NCT02790593_inc_T4", "normalized": [] }, { "id": "NCT02790593_inc_R3", "type": "AND", "arg1_id": "NCT02790593_inc_T8", "arg2_id": "NCT02790593_inc_T5", "normalized": [] }, { "id": "NCT02790593_inc_R4", "type": "Has_negation", "arg1_id": "NCT02790593_inc_T9", "arg2_id": "NCT02790593_inc_T10", "normalized": [] }, { "id": "NCT02790593_inc_R5", "type": "Has_value", "arg1_id": "NCT02790593_inc_T12", "arg2_id": "NCT02790593_inc_T13", "normalized": [] }, { "id": "NCT02790593_inc_R6", "type": "AND", "arg1_id": "NCT02790593_inc_T14", "arg2_id": "NCT02790593_inc_T9", "normalized": [] }, { "id": "NCT02790593_inc_R7", "type": "Has_value", "arg1_id": "NCT02790593_inc_T16", "arg2_id": "NCT02790593_inc_T17", "normalized": [] } ]

[ { "id": "NCT02796378_exc_text", "type": "exclusion", "text": [ "Cholesterol-lowering drugs\nDiabetes Mellitus\nCardiovascular disease such as arrythmia, ischaemic heart disease.\nMusculoskeletal disorders preventing the subject to perform physical training\nMental disorders preventing the subject to understand the project description.\n" ], "offsets": [ [ 0, 269 ] ] } ]

[ { "id": "NCT02796378_exc_T1", "type": "Drug", "text": [ "Cholesterol-lowering drugs" ], "offsets": [ [ 0, 26 ] ], "normalized": [] }, { "id": "NCT02796378_exc_T2", "type": "Condition", "text": [ "Diabetes Mellitus" ], "offsets": [ [ 27, 44 ] ], "normalized": [] }, { "id": "NCT02796378_exc_T3", "type": "Condition", "text": [ "Cardiovascular disease" ], "offsets": [ [ 45, 67 ] ], "normalized": [] }, { "id": "NCT02796378_exc_T4", "type": "Condition", "text": [ "arrythmia" ], "offsets": [ [ 76, 85 ] ], "normalized": [] }, { "id": "NCT02796378_exc_T5", "type": "Condition", "text": [ "ischaemic heart disease" ], "offsets": [ [ 87, 110 ] ], "normalized": [] }, { "id": "NCT02796378_exc_T6", "type": "Scope", "text": [ "arrythmia, ischaemic heart disease" ], "offsets": [ [ 76, 110 ] ], "normalized": [] }, { "id": "NCT02796378_exc_T7", "type": "Condition", "text": [ "Musculoskeletal disorders" ], "offsets": [ [ 112, 137 ] ], "normalized": [] }, { "id": "NCT02796378_exc_T8", "type": "Qualifier", "text": [ "preventing the subject to perform physical training" ], "offsets": [ [ 138, 189 ] ], "normalized": [] }, { "id": "NCT02796378_exc_T9", "type": "Condition", "text": [ "Mental disorders" ], "offsets": [ [ 190, 206 ] ], "normalized": [] }, { "id": "NCT02796378_exc_T10", "type": "Qualifier", "text": [ "preventing the subject to understand the project description" ], "offsets": [ [ 207, 267 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02796378_exc_R1", "type": "Subsumes", "arg1_id": "NCT02796378_exc_T3", "arg2_id": "NCT02796378_exc_T6", "normalized": [] }, { "id": "NCT02796378_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02796378_exc_T7", "arg2_id": "NCT02796378_exc_T8", "normalized": [] }, { "id": "NCT02796378_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02796378_exc_T9", "arg2_id": "NCT02796378_exc_T10", "normalized": [] } ]

[ { "id": "NCT02796378_inc_text", "type": "inclusion", "text": [ "Elevated blood-cholesterol\n" ], "offsets": [ [ 0, 27 ] ] } ]

[ { "id": "NCT02796378_inc_T1", "type": "Measurement", "text": [ "blood-cholesterol" ], "offsets": [ [ 9, 26 ] ], "normalized": [] }, { "id": "NCT02796378_inc_T2", "type": "Value", "text": [ "Elevated" ], "offsets": [ [ 0, 8 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02796378_inc_R1", "type": "Has_value", "arg1_id": "NCT02796378_inc_T1", "arg2_id": "NCT02796378_inc_T2", "normalized": [] } ]

[ { "id": "NCT02797548_exc_text", "type": "exclusion", "text": [ "Acute coronary syndrome within 1 month\nHeart failure NYHA III to IV\nContraindication to Aspirin\nOn anticoagulant therapy\nEmergent surgery\nCardiac surgery\nHigh bleeding risk surgeries, e.g., Intra-cranial surgery, Intra-spinal surgery, Retinal surgery\nPregnancy or breast-feeding\nLife expectancy less than 1year\n" ], "offsets": [ [ 0, 311 ] ] } ]

[ { "id": "NCT02797548_exc_T1", "type": "Condition", "text": [ "Acute coronary syndrome" ], "offsets": [ [ 0, 23 ] ], "normalized": [] }, { "id": "NCT02797548_exc_T2", "type": "Temporal", "text": [ "within 1 month" ], "offsets": [ [ 24, 38 ] ], "normalized": [] }, { "id": "NCT02797548_exc_T3", "type": "Condition", "text": [ "Heart failure" ], "offsets": [ [ 39, 52 ] ], "normalized": [] }, { "id": "NCT02797548_exc_T4", "type": "Measurement", "text": [ "NYHA" ], "offsets": [ [ 53, 57 ] ], "normalized": [] }, { "id": "NCT02797548_exc_T5", "type": "Value", "text": [ "III to IV" ], "offsets": [ [ 58, 67 ] ], "normalized": [] }, { "id": "NCT02797548_exc_T6", "type": "Condition", "text": [ "Contraindication" ], "offsets": [ [ 68, 84 ] ], "normalized": [] }, { "id": "NCT02797548_exc_T7", "type": "Drug", "text": [ "Aspirin" ], "offsets": [ [ 88, 95 ] ], "normalized": [] }, { "id": "NCT02797548_exc_T8", "type": "Procedure", "text": [ "anticoagulant therapy" ], "offsets": [ [ 99, 120 ] ], "normalized": [] }, { "id": "NCT02797548_exc_T9", "type": "Procedure", "text": [ "Emergent surgery" ], "offsets": [ [ 121, 137 ] ], "normalized": [] }, { "id": "NCT02797548_exc_T10", "type": "Procedure", "text": [ "Cardiac surgery" ], "offsets": [ [ 138, 153 ] ], "normalized": [] }, { "id": "NCT02797548_exc_T11", "type": "Condition", "text": [ "High bleeding risk surgeries" ], "offsets": [ [ 154, 182 ] ], "normalized": [] }, { "id": "NCT02797548_exc_T12", "type": "Condition", "text": [ "Intra-cranial surgery" ], "offsets": [ [ 190, 211 ] ], "normalized": [] }, { "id": "NCT02797548_exc_T13", "type": "Condition", "text": [ "Intra-spinal surgery" ], "offsets": [ [ 213, 233 ] ], "normalized": [] }, { "id": "NCT02797548_exc_T14", "type": "Condition", "text": [ "Retinal surgery" ], "offsets": [ [ 235, 250 ] ], "normalized": [] }, { "id": "NCT02797548_exc_T15", "type": "Scope", "text": [ "Intra-cranial surgery, Intra-spinal surgery, Retinal surgery" ], "offsets": [ [ 190, 250 ] ], "normalized": [] }, { "id": "NCT02797548_exc_T16", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 251, 260 ] ], "normalized": [] }, { "id": "NCT02797548_exc_T17", "type": "Condition", "text": [ "breast-feeding" ], "offsets": [ [ 264, 278 ] ], "normalized": [] }, { "id": "NCT02797548_exc_T18", "type": "Observation", "text": [ "Life expectancy" ], "offsets": [ [ 279, 294 ] ], "normalized": [] }, { "id": "NCT02797548_exc_T19", "type": "Value", "text": [ "less than 1year" ], "offsets": [ [ 295, 310 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02797548_exc_R1", "type": "AND", "arg1_id": "NCT02797548_exc_T6", "arg2_id": "NCT02797548_exc_T7", "normalized": [] }, { "id": "NCT02797548_exc_R2", "type": "Subsumes", "arg1_id": "NCT02797548_exc_T11", "arg2_id": "NCT02797548_exc_T15", "normalized": [] }, { "id": "NCT02797548_exc_R3", "type": "Has_value", "arg1_id": "NCT02797548_exc_T18", "arg2_id": "NCT02797548_exc_T19", "normalized": [] }, { "id": "NCT02797548_exc_R4", "type": "Has_value", "arg1_id": "NCT02797548_exc_T4", "arg2_id": "NCT02797548_exc_T5", "normalized": [] }, { "id": "NCT02797548_exc_R5", "type": "AND", "arg1_id": "NCT02797548_exc_T3", "arg2_id": "NCT02797548_exc_T4", "normalized": [] }, { "id": "NCT02797548_exc_R6", "type": "Has_temporal", "arg1_id": "NCT02797548_exc_T1", "arg2_id": "NCT02797548_exc_T2", "normalized": [] } ]

[ { "id": "NCT02797548_inc_text", "type": "inclusion", "text": [ "Planned non-cardiac surgery at least after 12 months of implantation of drug eluting stent\nLow or intermediate risk level surgery\nWritten informed consent\n" ], "offsets": [ [ 0, 155 ] ] } ]

[ { "id": "NCT02797548_inc_T1", "type": "Condition", "text": [ "non-cardiac surgery" ], "offsets": [ [ 8, 27 ] ], "normalized": [] }, { "id": "NCT02797548_inc_T2", "type": "Temporal", "text": [ "at least after 12 months of implantation of drug eluting stent" ], "offsets": [ [ 28, 90 ] ], "normalized": [] }, { "id": "NCT02797548_inc_T3", "type": "Reference_point", "text": [ "implantation of drug eluting stent" ], "offsets": [ [ 56, 90 ] ], "normalized": [] }, { "id": "NCT02797548_inc_T4", "type": "Procedure", "text": [ "implantation" ], "offsets": [ [ 56, 68 ] ], "normalized": [] }, { "id": "NCT02797548_inc_T5", "type": "Device", "text": [ "drug eluting stent" ], "offsets": [ [ 72, 90 ] ], "normalized": [] }, { "id": "NCT02797548_inc_T6", "type": "Mood", "text": [ "Planned" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "NCT02797548_inc_T8", "type": "Procedure", "text": [ "intermediate risk level surgery" ], "offsets": [ [ 98, 129 ] ], "normalized": [] }, { "id": "NCT02797548_inc_T9", "type": "Procedure", "text": [ "isk level surgery", "ow" ], "offsets": [ [ 112, 129 ], [ 92, 94 ] ], "normalized": [] }, { "id": "NCT02797548_inc_T10", "type": "Observation", "text": [ "Written informed consent" ], "offsets": [ [ 130, 154 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02797548_inc_R1", "type": "AND", "arg1_id": "NCT02797548_inc_T4", "arg2_id": "NCT02797548_inc_T5", "normalized": [] }, { "id": "NCT02797548_inc_R3", "type": "Has_index", "arg1_id": "NCT02797548_inc_T2", "arg2_id": "NCT02797548_inc_T3", "normalized": [] }, { "id": "NCT02797548_inc_R4", "type": "Has_temporal", "arg1_id": "NCT02797548_inc_T1", "arg2_id": "NCT02797548_inc_T2", "normalized": [] }, { "id": "NCT02797548_inc_R5", "type": "Has_mood", "arg1_id": "NCT02797548_inc_T1", "arg2_id": "NCT02797548_inc_T6", "normalized": [] } ]

[ { "id": "NCT02798237_exc_text", "type": "exclusion", "text": [ "cognitive impairment (Mini-Mental Status Examination score: illiterate 13 points; elementary and middle school 18 points; and high-school 26 points; or inability to respond to verbal command);\ninability to walk independently for at least 10 minutes, with or without walking devices;\npain or other disorders precluding their participation.\n" ], "offsets": [ [ 0, 339 ] ] } ]

[ { "id": "NCT02798237_exc_T1", "type": "Condition", "text": [ "cognitive impairment" ], "offsets": [ [ 0, 20 ] ], "normalized": [] }, { "id": "NCT02798237_exc_T2", "type": "Measurement", "text": [ "Mini-Mental Status Examination score" ], "offsets": [ [ 22, 58 ] ], "normalized": [] }, { "id": "NCT02798237_exc_T3", "type": "Observation", "text": [ "illiterate" ], "offsets": [ [ 60, 70 ] ], "normalized": [] }, { "id": "NCT02798237_exc_T4", "type": "Value", "text": [ "13 points" ], "offsets": [ [ 71, 80 ] ], "normalized": [] }, { "id": "NCT02798237_exc_T5", "type": "Observation", "text": [ "elementary" ], "offsets": [ [ 82, 92 ] ], "normalized": [] }, { "id": "NCT02798237_exc_T6", "type": "Observation", "text": [ "middle school" ], "offsets": [ [ 97, 110 ] ], "normalized": [] }, { "id": "NCT02798237_exc_T7", "type": "Value", "text": [ "18 points" ], "offsets": [ [ 111, 120 ] ], "normalized": [] }, { "id": "NCT02798237_exc_T8", "type": "Observation", "text": [ "high-school" ], "offsets": [ [ 126, 137 ] ], "normalized": [] }, { "id": "NCT02798237_exc_T9", "type": "Value", "text": [ "26 points" ], "offsets": [ [ 138, 147 ] ], "normalized": [] }, { "id": "NCT02798237_exc_T10", "type": "Scope", "text": [ "elementary and middle school" ], "offsets": [ [ 82, 110 ] ], "normalized": [] }, { "id": "NCT02798237_exc_T11", "type": "Condition", "text": [ "inability to respond to verbal command" ], "offsets": [ [ 152, 190 ] ], "normalized": [] }, { "id": "NCT02798237_exc_T12", "type": "Scope", "text": [ "illiterate 13 points; elementary and middle school 18 points; and high-school 26 points; or inability to respond to verbal command" ], "offsets": [ [ 60, 190 ] ], "normalized": [] }, { "id": "NCT02798237_exc_T13", "type": "Scope", "text": [ "Mini-Mental Status Examination score: illiterate 13 points; elementary and middle school 18 points; and high-school 26 points; or inability to respond to verbal command" ], "offsets": [ [ 22, 190 ] ], "normalized": [] }, { "id": "NCT02798237_exc_T14", "type": "Condition", "text": [ "inability to walk independently" ], "offsets": [ [ 193, 224 ] ], "normalized": [] }, { "id": "NCT02798237_exc_T15", "type": "Qualifier", "text": [ "at least 10 minutes" ], "offsets": [ [ 229, 248 ] ], "normalized": [] }, { "id": "NCT02798237_exc_T16", "type": "Device", "text": [ "walking devices" ], "offsets": [ [ 266, 281 ] ], "normalized": [] }, { "id": "NCT02798237_exc_T17", "type": "Condition", "text": [ "pain" ], "offsets": [ [ 283, 287 ] ], "normalized": [] }, { "id": "NCT02798237_exc_T18", "type": "Condition", "text": [ "other disorders" ], "offsets": [ [ 291, 306 ] ], "normalized": [] }, { "id": "NCT02798237_exc_T19", "type": "Qualifier", "text": [ "precluding their participation" ], "offsets": [ [ 307, 337 ] ], "normalized": [] }, { "id": "NCT02798237_exc_T20", "type": "Scope", "text": [ "pain or other disorders" ], "offsets": [ [ 283, 306 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02798237_exc_R1", "type": "Has_value", "arg1_id": "NCT02798237_exc_T10", "arg2_id": "NCT02798237_exc_T7", "normalized": [] }, { "id": "NCT02798237_exc_R2", "type": "Has_value", "arg1_id": "NCT02798237_exc_T3", "arg2_id": "NCT02798237_exc_T4", "normalized": [] }, { "id": "NCT02798237_exc_R3", "type": "Has_value", "arg1_id": "NCT02798237_exc_T8", "arg2_id": "NCT02798237_exc_T9", "normalized": [] }, { "id": "NCT02798237_exc_R4", "type": "Has_scope", "arg1_id": "NCT02798237_exc_T2", "arg2_id": "NCT02798237_exc_T12", "normalized": [] }, { "id": "NCT02798237_exc_R5", "type": "Subsumes", "arg1_id": "NCT02798237_exc_T1", "arg2_id": "NCT02798237_exc_T13", "normalized": [] }, { "id": "NCT02798237_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02798237_exc_T14", "arg2_id": "NCT02798237_exc_T15", "normalized": [] }, { "id": "NCT02798237_exc_R7", "type": "AND", "arg1_id": "NCT02798237_exc_T14", "arg2_id": "NCT02798237_exc_T16", "normalized": [] }, { "id": "NCT02798237_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT02798237_exc_T20", "arg2_id": "NCT02798237_exc_T19", "normalized": [] } ]

[ { "id": "NCT02798237_inc_text", "type": "inclusion", "text": [ "= 20years of age;\ndiagnosis of stroke (>6months);\nsedentary or insufficiently active;\nhave a writing medical permission to participate in the training program.\n" ], "offsets": [ [ 0, 160 ] ] } ]

[ { "id": "NCT02798237_inc_T1", "type": "Person", "text": [ "age" ], "offsets": [ [ 13, 16 ] ], "normalized": [] }, { "id": "NCT02798237_inc_T2", "type": "Value", "text": [ "= 20years" ], "offsets": [ [ 0, 9 ] ], "normalized": [] }, { "id": "NCT02798237_inc_T3", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 31, 37 ] ], "normalized": [] }, { "id": "NCT02798237_inc_T4", "type": "Temporal", "text": [ ">6months" ], "offsets": [ [ 39, 47 ] ], "normalized": [] }, { "id": "NCT02798237_inc_T5", "type": "Observation", "text": [ "sedentary" ], "offsets": [ [ 50, 59 ] ], "normalized": [] }, { "id": "NCT02798237_inc_T6", "type": "Observation", "text": [ "insufficiently active" ], "offsets": [ [ 63, 84 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02798237_inc_R1", "type": "Has_value", "arg1_id": "NCT02798237_inc_T1", "arg2_id": "NCT02798237_inc_T2", "normalized": [] }, { "id": "NCT02798237_inc_R2", "type": "Has_temporal", "arg1_id": "NCT02798237_inc_T3", "arg2_id": "NCT02798237_inc_T4", "normalized": [] } ]

[ { "id": "NCT02802644_exc_text", "type": "exclusion", "text": [ "Left main disease\nKnown hypersensitivity or contraindication to any of the following medications: Heparin, aspirin, clopidogrel, sirolimus, siptagliptin and statin\nCongestive heart failure (patients with LVEF <30% or cardiogenic shock)\nUncontrolled myocardial ischemia (repeated chest pain or dyspnea after revascularization)\nUncontrolled ventricular arrhythmia\nHistory of malignancy with chemotherapy\nSerious hematologic disease (e.g. CML, MDS)\nCurrent infectious disease needs antibiotics therapy\nCreatinine level >1.5 mg/dL or dependence on dialysis\nOther severe concurrent illness (e.g. active infection, malignancy).\nLife expectancy of less than one year\nPregnancy or women with potential childbearing\nType I DM\nTreatment with insulin\nHistory of pancreatitis\nWho cannot read the informed consent form (e.g. illiteracy, foreigner)\n" ], "offsets": [ [ 0, 835 ] ] } ]

[ { "id": "NCT02802644_exc_T1", "type": "Condition", "text": [ "Left main disease" ], "offsets": [ [ 0, 17 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T2", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 24, 40 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T3", "type": "Condition", "text": [ "contraindication" ], "offsets": [ [ 44, 60 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T4", "type": "Drug", "text": [ "Heparin" ], "offsets": [ [ 98, 105 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T5", "type": "Drug", "text": [ "aspirin" ], "offsets": [ [ 107, 114 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T6", "type": "Drug", "text": [ "clopidogrel" ], "offsets": [ [ 116, 127 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T7", "type": "Drug", "text": [ "sirolimus" ], "offsets": [ [ 129, 138 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T8", "type": "Drug", "text": [ "siptagliptin" ], "offsets": [ [ 140, 152 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T9", "type": "Drug", "text": [ "statin" ], "offsets": [ [ 157, 163 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T10", "type": "Scope", "text": [ "Heparin, aspirin, clopidogrel, sirolimus, siptagliptin and statin" ], "offsets": [ [ 98, 163 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T11", "type": "Scope", "text": [ "hypersensitivity or contraindication" ], "offsets": [ [ 24, 60 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T12", "type": "Condition", "text": [ "Congestive heart failure" ], "offsets": [ [ 164, 188 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T13", "type": "Measurement", "text": [ "LVEF" ], "offsets": [ [ 204, 208 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T14", "type": "Value", "text": [ "<30%" ], "offsets": [ [ 209, 213 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T15", "type": "Condition", "text": [ "cardiogenic shock" ], "offsets": [ [ 217, 234 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T16", "type": "Scope", "text": [ "VEF <30% or cardiogenic shock" ], "offsets": [ [ 205, 234 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T17", "type": "Condition", "text": [ "myocardial ischemia" ], "offsets": [ [ 249, 268 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T18", "type": "Qualifier", "text": [ "Uncontrolled" ], "offsets": [ [ 236, 248 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T19", "type": "Condition", "text": [ "chest pain" ], "offsets": [ [ 279, 289 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T20", "type": "Qualifier", "text": [ "repeated" ], "offsets": [ [ 270, 278 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T21", "type": "Condition", "text": [ "dyspnea" ], "offsets": [ [ 293, 300 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T22", "type": "Temporal", "text": [ "after revascularization" ], "offsets": [ [ 301, 324 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T23", "type": "Reference_point", "text": [ "revascularization" ], "offsets": [ [ 307, 324 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T24", "type": "Procedure", "text": [ "revascularization" ], "offsets": [ [ 307, 324 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T25", "type": "Scope", "text": [ "chest pain or dyspnea" ], "offsets": [ [ 279, 300 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T26", "type": "Condition", "text": [ "ventricular arrhythmia" ], "offsets": [ [ 339, 361 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T27", "type": "Qualifier", "text": [ "Uncontrolled" ], "offsets": [ [ 326, 338 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T28", "type": "Condition", "text": [ "malignancy" ], "offsets": [ [ 373, 383 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T29", "type": "Procedure", "text": [ "chemotherapy" ], "offsets": [ [ 389, 401 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T30", "type": "Condition", "text": [ "hematologic disease" ], "offsets": [ [ 410, 429 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T31", "type": "Qualifier", "text": [ "Serious" ], "offsets": [ [ 402, 409 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T32", "type": "Condition", "text": [ "CML" ], "offsets": [ [ 436, 439 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T33", "type": "Condition", "text": [ "MDS" ], "offsets": [ [ 441, 444 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T34", "type": "Scope", "text": [ "CML, MDS" ], "offsets": [ [ 436, 444 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T35", "type": "Condition", "text": [ "infectious disease" ], "offsets": [ [ 454, 472 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T36", "type": "Drug", "text": [ "antibiotics" ], "offsets": [ [ 479, 490 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T37", "type": "Measurement", "text": [ "Creatinine level" ], "offsets": [ [ 499, 515 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T38", "type": "Value", "text": [ ">1.5 mg/dL" ], "offsets": [ [ 516, 526 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T39", "type": "Procedure", "text": [ "dialysis" ], "offsets": [ [ 544, 552 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T40", "type": "Condition", "text": [ "active infection" ], "offsets": [ [ 591, 607 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T41", "type": "Condition", "text": [ "malignancy" ], "offsets": [ [ 609, 619 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T42", "type": "Condition", "text": [ "illness" ], "offsets": [ [ 577, 584 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T43", "type": "Qualifier", "text": [ "concurrent" ], "offsets": [ [ 566, 576 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T44", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 559, 565 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T45", "type": "Scope", "text": [ "active infection, malignancy" ], "offsets": [ [ 591, 619 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T46", "type": "Observation", "text": [ "ife expectancy" ], "offsets": [ [ 623, 637 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T47", "type": "Value", "text": [ "less than one year" ], "offsets": [ [ 641, 659 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T49", "type": "Condition", "text": [ "Type I DM" ], "offsets": [ [ 707, 716 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T50", "type": "Drug", "text": [ "insulin" ], "offsets": [ [ 732, 739 ] ], "normalized": [] }, { "id": "NCT02802644_exc_T51", "type": "Condition", "text": [ "pancreatitis" ], "offsets": [ [ 751, 763 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02802644_exc_R1", "type": "Has_scope", "arg1_id": "NCT02802644_exc_T11", "arg2_id": "NCT02802644_exc_T10", "normalized": [] }, { "id": "NCT02802644_exc_R2", "type": "Has_value", "arg1_id": "NCT02802644_exc_T13", "arg2_id": "NCT02802644_exc_T14", "normalized": [] }, { "id": "NCT02802644_exc_R3", "type": "Subsumes", "arg1_id": "NCT02802644_exc_T12", "arg2_id": "NCT02802644_exc_T16", "normalized": [] }, { "id": "NCT02802644_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT02802644_exc_T17", "arg2_id": "NCT02802644_exc_T18", "normalized": [] }, { "id": "NCT02802644_exc_R5", "type": "Has_index", "arg1_id": "NCT02802644_exc_T22", "arg2_id": "NCT02802644_exc_T23", "normalized": [] }, { "id": "NCT02802644_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT02802644_exc_T25", "arg2_id": "NCT02802644_exc_T20", "normalized": [] }, { "id": "NCT02802644_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02802644_exc_T25", "arg2_id": "NCT02802644_exc_T22", "normalized": [] }, { "id": "NCT02802644_exc_R9", "type": "Subsumes", "arg1_id": "NCT02802644_exc_T17", "arg2_id": "NCT02802644_exc_T25", "normalized": [] }, { "id": "NCT02802644_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT02802644_exc_T26", "arg2_id": "NCT02802644_exc_T27", "normalized": [] }, { "id": "NCT02802644_exc_R11", "type": "AND", "arg1_id": "NCT02802644_exc_T28", "arg2_id": "NCT02802644_exc_T29", "normalized": [] }, { "id": "NCT02802644_exc_R12", "type": "Has_qualifier", "arg1_id": "NCT02802644_exc_T30", "arg2_id": "NCT02802644_exc_T31", "normalized": [] }, { "id": "NCT02802644_exc_R13", "type": "Subsumes", "arg1_id": "NCT02802644_exc_T30", "arg2_id": "NCT02802644_exc_T34", "normalized": [] }, { "id": "NCT02802644_exc_R14", "type": "AND", "arg1_id": "NCT02802644_exc_T35", "arg2_id": "NCT02802644_exc_T36", "normalized": [] }, { "id": "NCT02802644_exc_R15", "type": "Has_value", "arg1_id": "NCT02802644_exc_T37", "arg2_id": "NCT02802644_exc_T38", "normalized": [] }, { "id": "NCT02802644_exc_R16", "type": "Has_qualifier", "arg1_id": "NCT02802644_exc_T42", "arg2_id": "NCT02802644_exc_T43", "normalized": [] }, { "id": "NCT02802644_exc_R17", "type": "Has_qualifier", "arg1_id": "NCT02802644_exc_T42", "arg2_id": "NCT02802644_exc_T44", "normalized": [] }, { "id": "NCT02802644_exc_R18", "type": "Subsumes", "arg1_id": "NCT02802644_exc_T42", "arg2_id": "NCT02802644_exc_T45", "normalized": [] }, { "id": "NCT02802644_exc_R19", "type": "Has_value", "arg1_id": "NCT02802644_exc_T46", "arg2_id": "NCT02802644_exc_T47", "normalized": [] } ]

[ { "id": "NCT02802644_inc_text", "type": "inclusion", "text": [ "Non-ST segement elevation acute coronary syndrome\n" ], "offsets": [ [ 0, 50 ] ] } ]

[ { "id": "NCT02802644_inc_T1", "type": "Condition", "text": [ "Non-ST segement elevation" ], "offsets": [ [ 0, 25 ] ], "normalized": [] }, { "id": "NCT02802644_inc_T2", "type": "Condition", "text": [ "acute coronary syndrome" ], "offsets": [ [ 26, 49 ] ], "normalized": [] } ]

[]

[]

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[ { "id": "NCT02804126_exc_text", "type": "exclusion", "text": [ "coagulopathy\nallergy to to local anesthetics\ndepression, antidepressant drugs treatment\nepilepsy\nusage of painkiller before surgery\naddiction to alcohol or recreational drugs\n" ], "offsets": [ [ 0, 175 ] ] } ]

[ { "id": "NCT02804126_exc_T1", "type": "Condition", "text": [ "coagulopathy" ], "offsets": [ [ 0, 12 ] ], "normalized": [] }, { "id": "NCT02804126_exc_T2", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 13, 20 ] ], "normalized": [] }, { "id": "NCT02804126_exc_T3", "type": "Drug", "text": [ "local anesthetics" ], "offsets": [ [ 27, 44 ] ], "normalized": [] }, { "id": "NCT02804126_exc_T4", "type": "Condition", "text": [ "depression" ], "offsets": [ [ 45, 55 ] ], "normalized": [] }, { "id": "NCT02804126_exc_T5", "type": "Drug", "text": [ "antidepressant drugs" ], "offsets": [ [ 57, 77 ] ], "normalized": [] }, { "id": "NCT02804126_exc_T6", "type": "Condition", "text": [ "epilepsy" ], "offsets": [ [ 88, 96 ] ], "normalized": [] }, { "id": "NCT02804126_exc_T7", "type": "Drug", "text": [ "painkiller" ], "offsets": [ [ 106, 116 ] ], "normalized": [] }, { "id": "NCT02804126_exc_T8", "type": "Temporal", "text": [ "before surgery" ], "offsets": [ [ 117, 131 ] ], "normalized": [] }, { "id": "NCT02804126_exc_T9", "type": "Condition", "text": [ "addiction to alcohol" ], "offsets": [ [ 132, 152 ] ], "normalized": [] }, { "id": "NCT02804126_exc_T10", "type": "Condition", "text": [ "tion to alco", "ational drugs" ], "offsets": [ [ 137, 149 ], [ 161, 174 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02804126_exc_R1", "type": "AND", "arg1_id": "NCT02804126_exc_T2", "arg2_id": "NCT02804126_exc_T3", "normalized": [] }, { "id": "NCT02804126_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02804126_exc_T7", "arg2_id": "NCT02804126_exc_T8", "normalized": [] }, { "id": "NCT02804126_exc_R3", "type": "AND", "arg1_id": "NCT02804126_exc_T4", "arg2_id": "NCT02804126_exc_T5", "normalized": [] } ]

[ { "id": "NCT02804126_inc_text", "type": "inclusion", "text": [ "obtained consent\nsingleton pregnancy\nsubarachnoid anaesthesia\n" ], "offsets": [ [ 0, 62 ] ] } ]

[ { "id": "NCT02804126_inc_T2", "type": "Condition", "text": [ "pregnancy" ], "offsets": [ [ 27, 36 ] ], "normalized": [] }, { "id": "NCT02804126_inc_T3", "type": "Qualifier", "text": [ "singleton" ], "offsets": [ [ 17, 26 ] ], "normalized": [] }, { "id": "NCT02804126_inc_T4", "type": "Procedure", "text": [ "subarachnoid anaesthesia" ], "offsets": [ [ 37, 61 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02804126_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT02804126_inc_T2", "arg2_id": "NCT02804126_inc_T3", "normalized": [] } ]

[ { "id": "NCT02804646_exc_text", "type": "exclusion", "text": [ "1) pregnancy, breast-feeding women, or female patients of childbearing potential but did not take contraceptive measures;2) existing severe acute infection and is not controlled; or purulent and chronic infection, delayed healing wounds; 3) the original severe heart disease, including congestive heart failure, uncontrolled high-risk arrhythmias, unstable angina, myocardial infarction, severe heart valve disease and resistant hypertension; 4) suffering from neurological and psychiatric diseases or mental disorders is not easy to control, poor compliance, and can not be described with treatment responders; primary brain or central nervous metastasis disease has not been controlled, with significant cranial hypertension or neuropsychiatric symptoms; 5) have bleeding tendencies; 6) other researchers believe that patients should not participate in the present trial.\n" ], "offsets": [ [ 0, 874 ] ] } ]

[ { "id": "NCT02804646_exc_T8", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 133, 139 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T9", "type": "Qualifier", "text": [ "acute" ], "offsets": [ [ 140, 145 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T10", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 146, 155 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T11", "type": "Qualifier", "text": [ "not controlled" ], "offsets": [ [ 163, 177 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T12", "type": "Qualifier", "text": [ "chronic" ], "offsets": [ [ 195, 202 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T13", "type": "Qualifier", "text": [ "purulent" ], "offsets": [ [ 182, 190 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T14", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 203, 212 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T15", "type": "Condition", "text": [ "delayed healing wounds" ], "offsets": [ [ 214, 236 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T16", "type": "Scope", "text": [ "purulent and chronic infection, delayed healing wounds" ], "offsets": [ [ 182, 236 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T17", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 254, 260 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T18", "type": "Condition", "text": [ "heart disease" ], "offsets": [ [ 261, 274 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T19", "type": "Condition", "text": [ "congestive heart failure" ], "offsets": [ [ 286, 310 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T20", "type": "Qualifier", "text": [ "uncontrolled" ], "offsets": [ [ 312, 324 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T21", "type": "Qualifier", "text": [ "high-risk" ], "offsets": [ [ 325, 334 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T22", "type": "Condition", "text": [ "arrhythmias" ], "offsets": [ [ 335, 346 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T23", "type": "Condition", "text": [ "unstable angina" ], "offsets": [ [ 348, 363 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T24", "type": "Condition", "text": [ "myocardial infarction" ], "offsets": [ [ 365, 386 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T25", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 388, 394 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T26", "type": "Condition", "text": [ "heart valve disease" ], "offsets": [ [ 395, 414 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T27", "type": "Qualifier", "text": [ "resistant" ], "offsets": [ [ 419, 428 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T28", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 429, 441 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T29", "type": "Scope", "text": [ "congestive heart failure, uncontrolled high-risk arrhythmias, unstable angina, myocardial infarction, severe heart valve disease and resistant hypertension" ], "offsets": [ [ 286, 441 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T30", "type": "Condition", "text": [ "psychiatric diseases" ], "offsets": [ [ 478, 498 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T31", "type": "Condition", "text": [ "neurological", "diseases" ], "offsets": [ [ 461, 473 ], [ 490, 498 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T32", "type": "Condition", "text": [ "mental disorders" ], "offsets": [ [ 502, 518 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T33", "type": "Condition", "text": [ "poor compliance" ], "offsets": [ [ 543, 558 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T34", "type": "Condition", "text": [ "central nervous metastasis disease" ], "offsets": [ [ 629, 663 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T35", "type": "Condition", "text": [ "primary brain", "disease" ], "offsets": [ [ 612, 625 ], [ 656, 663 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T36", "type": "Negation", "text": [ "not" ], "offsets": [ [ 668, 671 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T37", "type": "Qualifier", "text": [ "controlled" ], "offsets": [ [ 677, 687 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T38", "type": "Scope", "text": [ "primary brain or central nervous metastasis disease" ], "offsets": [ [ 612, 663 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T39", "type": "Qualifier", "text": [ "significant" ], "offsets": [ [ 694, 705 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T40", "type": "Condition", "text": [ "cranial hypertension" ], "offsets": [ [ 706, 726 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T41", "type": "Condition", "text": [ "neuropsychiatric symptoms" ], "offsets": [ [ 730, 755 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T42", "type": "Condition", "text": [ "bleeding tendencies" ], "offsets": [ [ 765, 784 ] ], "normalized": [] }, { "id": "NCT02804646_exc_T43", "type": "Scope", "text": [ "cranial hypertension or neuropsychiatric symptoms" ], "offsets": [ [ 706, 755 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02804646_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02804646_exc_T10", "arg2_id": "NCT02804646_exc_T9", "normalized": [] }, { "id": "NCT02804646_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02804646_exc_T10", "arg2_id": "NCT02804646_exc_T8", "normalized": [] }, { "id": "NCT02804646_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02804646_exc_T10", "arg2_id": "NCT02804646_exc_T11", "normalized": [] }, { "id": "NCT02804646_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT02804646_exc_T14", "arg2_id": "NCT02804646_exc_T12", "normalized": [] }, { "id": "NCT02804646_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02804646_exc_T14", "arg2_id": "NCT02804646_exc_T13", "normalized": [] }, { "id": "NCT02804646_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02804646_exc_T18", "arg2_id": "NCT02804646_exc_T17", "normalized": [] }, { "id": "NCT02804646_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT02804646_exc_T22", "arg2_id": "NCT02804646_exc_T21", "normalized": [] }, { "id": "NCT02804646_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT02804646_exc_T22", "arg2_id": "NCT02804646_exc_T20", "normalized": [] }, { "id": "NCT02804646_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT02804646_exc_T28", "arg2_id": "NCT02804646_exc_T27", "normalized": [] }, { "id": "NCT02804646_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT02804646_exc_T26", "arg2_id": "NCT02804646_exc_T25", "normalized": [] }, { "id": "NCT02804646_exc_R11", "type": "Subsumes", "arg1_id": "NCT02804646_exc_T18", "arg2_id": "NCT02804646_exc_T29", "normalized": [] }, { "id": "NCT02804646_exc_R12", "type": "Has_negation", "arg1_id": "NCT02804646_exc_T37", "arg2_id": "NCT02804646_exc_T36", "normalized": [] }, { "id": "NCT02804646_exc_R13", "type": "Has_qualifier", "arg1_id": "NCT02804646_exc_T38", "arg2_id": "NCT02804646_exc_T37", "normalized": [] }, { "id": "NCT02804646_exc_R14", "type": "Has_qualifier", "arg1_id": "NCT02804646_exc_T43", "arg2_id": "NCT02804646_exc_T39", "normalized": [] } ]

[ { "id": "NCT02804646_inc_text", "type": "inclusion", "text": [ "1) histologically confirmed (patients not receiving a single sputum cytology diagnosis) non-small cell lung cancer patients,with wild-type EGFR and ALK-negative; 2) According to IASLC2009 new TNM staging of lung cancer stage <U+2162>B or <U+2163>, previously untreated or relapsed after 1 year of lung cancer resection; 3) have at least one evaluable lesions,according to version 1.1 of the standard in accordance with a judgment RECIST(longest diameter on a spiral CT at least 10mm,on a regular CT longest diameter at least 20mm); 4) Male or female, aged 18 to 75 years; 5) ECOG PS 0 or 1; 6) expected survival at least 3 months; 7) adequate hematological function: absolute neutrophil count (ANC) at least 2×10^9/L and platelet count at least 100×10^9/L and hemoglobin at least 9 g/dL; 8) adequate liver function: total bilirubin less than upper limit of normal (ULN); AST and ALT less than 2.5 times upper limit of normal (ULN); alkaline phosphatase less than 5 times the upper limit of normal (ULN); 9) adequate renal function: serum creatinine less than upper limit of normal (ULN) or calculated creatinine clearance at least 60 mL/min; 10) ECG is normal, there is no non-healing wounds on the body; 11) had not received previous treatment anticancer drugs, or had only received for previous non-metastatic tumors adjuvant or neoadjuvant chemotherapy, but when you start to study treatment has ended more than 6 months; 12) have conducted previous surgery patients required to study treatment was started more than four weeks, and the patient had recovered; 13) have an intact uterus in women prior to enrollment in the study must have a negative pregnancy test result (unless it is already 24 months of amenorrhea) within 28 days. If the pregnancy test from the first administration more than seven days, urine pregnancy test is required for authentication (less than 7 days before the first dose); 14) previous to biological agents, particularly E.coli genetically engineered products without serious allergic reactions; 15) signed informed consent.\n" ], "offsets": [ [ 0, 2057 ] ] } ]

[ { "id": "NCT02804646_inc_T1", "type": "Qualifier", "text": [ "histologically confirmed" ], "offsets": [ [ 3, 27 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T2", "type": "Condition", "text": [ "non-small cell lung cancer" ], "offsets": [ [ 88, 114 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T3", "type": "Qualifier", "text": [ "wild-type EGFR" ], "offsets": [ [ 129, 143 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T4", "type": "Qualifier", "text": [ "ALK-negative" ], "offsets": [ [ 148, 160 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T5", "type": "Measurement", "text": [ "IASLC2009 new TNM staging" ], "offsets": [ [ 178, 203 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T6", "type": "Condition", "text": [ "lung cancer" ], "offsets": [ [ 207, 218 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T7", "type": "Value", "text": [ "stage <U+2162>B or <U+2163>" ], "offsets": [ [ 219, 246 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T8", "type": "Qualifier", "text": [ "untreated" ], "offsets": [ [ 259, 268 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T9", "type": "Qualifier", "text": [ "relapsed" ], "offsets": [ [ 272, 280 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T10", "type": "Temporal", "text": [ "after 1 year of lung cancer resection" ], "offsets": [ [ 281, 318 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T11", "type": "Reference_point", "text": [ "lung cancer resection" ], "offsets": [ [ 297, 318 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T12", "type": "Scope", "text": [ "untreated or relapsed" ], "offsets": [ [ 259, 280 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T13", "type": "Multiplier", "text": [ "at least one" ], "offsets": [ [ 328, 340 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T14", "type": "Condition", "text": [ "evaluable lesions" ], "offsets": [ [ 341, 358 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T15", "type": "Measurement", "text": [ "longest diameter" ], "offsets": [ [ 437, 453 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T16", "type": "Procedure", "text": [ "spiral CT" ], "offsets": [ [ 459, 468 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T17", "type": "Value", "text": [ "at least 10mm" ], "offsets": [ [ 469, 482 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T18", "type": "Procedure", "text": [ "regular CT" ], "offsets": [ [ 488, 498 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T19", "type": "Measurement", "text": [ "longest diameter" ], "offsets": [ [ 499, 515 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T20", "type": "Value", "text": [ "at least 20mm" ], "offsets": [ [ 516, 529 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T21", "type": "Person", "text": [ "Male" ], "offsets": [ [ 535, 539 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T22", "type": "Person", "text": [ "female" ], "offsets": [ [ 543, 549 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T23", "type": "Person", "text": [ "aged" ], "offsets": [ [ 551, 555 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T24", "type": "Value", "text": [ "18 to 75 years" ], "offsets": [ [ 556, 570 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T25", "type": "Measurement", "text": [ "ECOG PS" ], "offsets": [ [ 575, 582 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T26", "type": "Value", "text": [ "0 or 1" ], "offsets": [ [ 583, 589 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T27", "type": "Observation", "text": [ "expected survival" ], "offsets": [ [ 594, 611 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T28", "type": "Temporal", "text": [ "at least 3 months" ], "offsets": [ [ 612, 629 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T29", "type": "Condition", "text": [ "adequate hematological function" ], "offsets": [ [ 634, 665 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T30", "type": "Measurement", "text": [ "absolute neutrophil count (ANC)" ], "offsets": [ [ 667, 698 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T31", "type": "Value", "text": [ "at least 2×10^9/L" ], "offsets": [ [ 699, 716 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T32", "type": "Measurement", "text": [ "platelet count" ], "offsets": [ [ 721, 735 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T33", "type": "Value", "text": [ "at least 100×10^9/L" ], "offsets": [ [ 736, 755 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T34", "type": "Measurement", "text": [ "hemoglobin" ], "offsets": [ [ 760, 770 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T35", "type": "Value", "text": [ "at least 9 g/dL" ], "offsets": [ [ 771, 786 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T36", "type": "Scope", "text": [ "absolute neutrophil count (ANC) at least 2×10^9/L and platelet count at least 100×10^9/L and hemoglobin at least 9 g/dL" ], "offsets": [ [ 667, 786 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T37", "type": "Condition", "text": [ "adequate liver function" ], "offsets": [ [ 791, 814 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T38", "type": "Measurement", "text": [ "total bilirubin" ], "offsets": [ [ 816, 831 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T39", "type": "Value", "text": [ "less than upper limit of normal (ULN)" ], "offsets": [ [ 832, 869 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T40", "type": "Measurement", "text": [ "AST" ], "offsets": [ [ 871, 874 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T41", "type": "Measurement", "text": [ "ALT" ], "offsets": [ [ 879, 882 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T42", "type": "Value", "text": [ "less than 2.5 times upper limit of normal (ULN)" ], "offsets": [ [ 883, 930 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T43", "type": "Measurement", "text": [ "alkaline phosphatase" ], "offsets": [ [ 932, 952 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T44", "type": "Value", "text": [ "less than 5 times the upper limit of normal (ULN)" ], "offsets": [ [ 953, 1002 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T45", "type": "Condition", "text": [ "adequate renal function" ], "offsets": [ [ 1007, 1030 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T46", "type": "Measurement", "text": [ "serum creatinine" ], "offsets": [ [ 1032, 1048 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T47", "type": "Value", "text": [ "less than upper limit of normal (ULN)" ], "offsets": [ [ 1049, 1086 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T48", "type": "Measurement", "text": [ "calculated creatinine clearance" ], "offsets": [ [ 1090, 1121 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T49", "type": "Value", "text": [ "at least 60 mL/min" ], "offsets": [ [ 1122, 1140 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T50", "type": "Measurement", "text": [ "ECG" ], "offsets": [ [ 1146, 1149 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T51", "type": "Value", "text": [ "normal" ], "offsets": [ [ 1153, 1159 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T52", "type": "Negation", "text": [ "no" ], "offsets": [ [ 1170, 1172 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T53", "type": "Condition", "text": [ "non-healing wounds on the body" ], "offsets": [ [ 1173, 1203 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T54", "type": "Scope", "text": [ "serum creatinine less than upper limit of normal (ULN) or calculated creatinine clearance at least 60 mL/min" ], "offsets": [ [ 1032, 1140 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T55", "type": "Scope", "text": [ "total bilirubin less than upper limit of normal (ULN); AST and ALT less than 2.5 times upper limit of normal (ULN); alkaline phosphatase less than 5 times the upper limit of normal (ULN)" ], "offsets": [ [ 816, 1002 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T56", "type": "Drug", "text": [ "anticancer drugs" ], "offsets": [ [ 1245, 1261 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T57", "type": "Negation", "text": [ "not received" ], "offsets": [ [ 1213, 1225 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T58", "type": "Condition", "text": [ "non-metastatic tumors" ], "offsets": [ [ 1297, 1318 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T59", "type": "Qualifier", "text": [ "neoadjuvant" ], "offsets": [ [ 1331, 1342 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T60", "type": "Qualifier", "text": [ "adjuvant" ], "offsets": [ [ 1319, 1327 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T61", "type": "Procedure", "text": [ "chemotherapy" ], "offsets": [ [ 1343, 1355 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T62", "type": "Scope", "text": [ "adjuvant or neoadjuvant" ], "offsets": [ [ 1319, 1342 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T63", "type": "Temporal", "text": [ "ended more than 6 months" ], "offsets": [ [ 1399, 1423 ] ], "normalized": [] }, { "id": "NCT02804646_inc_T64", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 1288, 1296 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT02804646_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT02804646_inc_T2", "arg2_id": "NCT02804646_inc_T3", "normalized": [] }, { "id": "NCT02804646_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02804646_inc_T2", "arg2_id": "NCT02804646_inc_T4", "normalized": [] }, { "id": "NCT02804646_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT02804646_inc_T2", "arg2_id": "NCT02804646_inc_T1", "normalized": [] }, { "id": "NCT02804646_inc_R4", "type": "Has_value", "arg1_id": "NCT02804646_inc_T5", "arg2_id": "NCT02804646_inc_T7", "normalized": [] }, { "id": "NCT02804646_inc_R5", "type": "AND", "arg1_id": "NCT02804646_inc_T6", "arg2_id": "NCT02804646_inc_T5", "normalized": [] }, { "id": "NCT02804646_inc_R6", "type": "Has_index", "arg1_id": "NCT02804646_inc_T10", "arg2_id": "NCT02804646_inc_T11", "normalized": [] }, { "id": "NCT02804646_inc_R7", "type": "Has_scope", "arg1_id": "NCT02804646_inc_T6", "arg2_id": "NCT02804646_inc_T12", "normalized": [] }, { "id": "NCT02804646_inc_R8", "type": "Has_temporal", "arg1_id": "NCT02804646_inc_T6", "arg2_id": "NCT02804646_inc_T10", "normalized": [] }, { "id": "NCT02804646_inc_R9", "type": "Has_multiplier", "arg1_id": "NCT02804646_inc_T14", "arg2_id": "NCT02804646_inc_T13", "normalized": [] }, { "id": "NCT02804646_inc_R10", "type": "Has_value", "arg1_id": "NCT02804646_inc_T15", "arg2_id": "NCT02804646_inc_T17", "normalized": [] }, { "id": "NCT02804646_inc_R11", "type": "AND", "arg1_id": "NCT02804646_inc_T16", "arg2_id": "NCT02804646_inc_T15", "normalized": [] }, { "id": "NCT02804646_inc_R12", "type": "AND", "arg1_id": "NCT02804646_inc_T18", "arg2_id": "NCT02804646_inc_T19", "normalized": [] }, { "id": "NCT02804646_inc_R13", "type": "Has_value", "arg1_id": "NCT02804646_inc_T19", "arg2_id": "NCT02804646_inc_T20", "normalized": [] }, { "id": "NCT02804646_inc_R14", "type": "Has_value", "arg1_id": "NCT02804646_inc_T23", "arg2_id": "NCT02804646_inc_T24", "normalized": [] }, { "id": "NCT02804646_inc_R15", "type": "Has_value", "arg1_id": "NCT02804646_inc_T25", "arg2_id": "NCT02804646_inc_T26", "normalized": [] }, { "id": "NCT02804646_inc_R16", "type": "Has_temporal", "arg1_id": "NCT02804646_inc_T27", "arg2_id": "NCT02804646_inc_T28", "normalized": [] }, { "id": "NCT02804646_inc_R17", "type": "Has_value", "arg1_id": "NCT02804646_inc_T32", "arg2_id": "NCT02804646_inc_T33", "normalized": [] }, { "id": "NCT02804646_inc_R18", "type": "Has_value", "arg1_id": "NCT02804646_inc_T34", "arg2_id": "NCT02804646_inc_T35", "normalized": [] }, { "id": "NCT02804646_inc_R19", "type": "Has_value", "arg1_id": "NCT02804646_inc_T30", "arg2_id": "NCT02804646_inc_T31", "normalized": [] }, { "id": "NCT02804646_inc_R20", "type": "Subsumes", "arg1_id": "NCT02804646_inc_T29", "arg2_id": "NCT02804646_inc_T36", "normalized": [] }, { "id": "NCT02804646_inc_R21", "type": "Has_value", "arg1_id": "NCT02804646_inc_T38", "arg2_id": "NCT02804646_inc_T39", "normalized": [] }, { "id": "NCT02804646_inc_R22", "type": "Has_value", "arg1_id": "NCT02804646_inc_T41", "arg2_id": "NCT02804646_inc_T42", "normalized": [] }, { "id": "NCT02804646_inc_R23", "type": "Has_value", "arg1_id": "NCT02804646_inc_T40", "arg2_id": "NCT02804646_inc_T42", "normalized": [] }, { "id": "NCT02804646_inc_R24", "type": "Has_value", "arg1_id": "NCT02804646_inc_T43", "arg2_id": "NCT02804646_inc_T44", "normalized": [] }, { "id": "NCT02804646_inc_R25", "type": "Has_value", "arg1_id": "NCT02804646_inc_T46", "arg2_id": "NCT02804646_inc_T47", "normalized": [] }, { "id": "NCT02804646_inc_R26", "type": "Has_value", "arg1_id": "NCT02804646_inc_T48", "arg2_id": "NCT02804646_inc_T49", "normalized": [] }, { "id": "NCT02804646_inc_R27", "type": "Has_value", "arg1_id": "NCT02804646_inc_T50", "arg2_id": "NCT02804646_inc_T51", "normalized": [] }, { "id": "NCT02804646_inc_R28", "type": "Has_negation", "arg1_id": "NCT02804646_inc_T53", "arg2_id": "NCT02804646_inc_T52", "normalized": [] }, { "id": "NCT02804646_inc_R29", "type": "Subsumes", "arg1_id": "NCT02804646_inc_T45", "arg2_id": "NCT02804646_inc_T54", "normalized": [] }, { "id": "NCT02804646_inc_R30", "type": "Subsumes", "arg1_id": "NCT02804646_inc_T37", "arg2_id": "NCT02804646_inc_T55", "normalized": [] }, { "id": "NCT02804646_inc_R31", "type": "Has_negation", "arg1_id": "NCT02804646_inc_T56", "arg2_id": "NCT02804646_inc_T57", "normalized": [] }, { "id": "NCT02804646_inc_R32", "type": "Has_scope", "arg1_id": "NCT02804646_inc_T61", "arg2_id": "NCT02804646_inc_T62", "normalized": [] }, { "id": "NCT02804646_inc_R33", "type": "AND", "arg1_id": "NCT02804646_inc_T61", "arg2_id": "NCT02804646_inc_T58", "normalized": [] }, { "id": "NCT02804646_inc_R34", "type": "Has_temporal", "arg1_id": "NCT02804646_inc_T61", "arg2_id": "NCT02804646_inc_T63", "normalized": [] }, { "id": "NCT02804646_inc_R35", "type": "Has_temporal", "arg1_id": "NCT02804646_inc_T58", "arg2_id": "NCT02804646_inc_T64", "normalized": [] } ]

[ { "id": "NCT02805504_exc_text", "type": "exclusion", "text": [ "Pregnant and/or nursing mothers.\nAllergy to bupivacaine.\nHistory of drug/alcohol abuse.\nSevere cardiovascular, hepatic, renal disease or neurological impairment.\n" ], "offsets": [ [ 0, 162 ] ] } ]

[ { "id": "NCT02805504_exc_T1", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT02805504_exc_T2", "type": "Condition", "text": [ "nursing" ], "offsets": [ [ 16, 23 ] ], "normalized": [] }, { "id": "NCT02805504_exc_T3", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 33, 40 ] ], "normalized": [] }, { "id": "NCT02805504_exc_T4", "type": "Drug", "text": [ "bupivacaine" ], "offsets": [ [ 44, 55 ] ], "normalized": [] }, { "id": "NCT02805504_exc_T5", "type": "Condition", "text": [ "drug/alcohol abuse" ], "offsets": [ [ 68, 86 ] ], "normalized": [] }, { "id": "NCT02805504_exc_T6", "type": "Observation", "text": [ "History" ], "offsets": [ [ 57, 64 ] ], "normalized": [] }, { "id": "NCT02805504_exc_T7", "type": "Condition", "text": [ "ease or", "diovascular, h" ], "offsets": [ [ 129, 136 ], [ 98, 112 ] ], "normalized": [] }, { "id": "NCT02805504_exc_T8", "type": "Condition", "text": [ "atic, r", "ease or" ], "offsets": [ [ 114, 121 ], [ 129, 136 ] ], "normalized": [] }, { "id": "NCT02805504_exc_T9", "type": "Condition", "text": [ "renal disease" ], "offsets": [ [ 120, 133 ] ], "normalized": [] }, { "id": "NCT02805504_exc_T10", "type": "Condition", "text": [ "neurological impairment" ], "offsets": [ [ 137, 160 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02805504_exc_R1", "type": "AND", "arg1_id": "NCT02805504_exc_T3", "arg2_id": "NCT02805504_exc_T4", "normalized": [] }, { "id": "NCT02805504_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02805504_exc_T5", "arg2_id": "NCT02805504_exc_T6", "normalized": [] } ]

[ { "id": "NCT02805504_inc_text", "type": "inclusion", "text": [ "Patients undergoing urologic surgery.\n" ], "offsets": [ [ 0, 38 ] ] } ]

[ { "id": "NCT02805504_inc_T1", "type": "Procedure", "text": [ "urologic surgery" ], "offsets": [ [ 20, 36 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "NCT02807857_exc_text", "type": "exclusion", "text": [ "Use of investigational drugs either within 5 half-lives of enrollment, or within 30 days, or until the expected pharmacodynamic effect has returned to baseline, whichever is longer.\nMajor surgery in the last 3 months prior to baseline or planned major surgery or cardiac intervention during the study.\nCancer or other significant co-morbidities implying that the patient's condition is unstable.\nComorbidities that can be associated with elevated natriuretic peptide (NP) levels: renal insufficiency, (eGFR < 25 ml/min/1.73 m² calculated according to MDRD formula), recent (less than 3 months) cerebral trauma or recent (less than 3 months) cerebrovascular incident, novel diagnosis or acute exacerbation of COPD within the last 3 months.\nPatients who are primarily managed and regularly followed-up by a cardiologist for their HF\nHighly frail patients whose estimated lifespan due to comorbidities by the judgement of the investigator is less than 6 months.\n" ], "offsets": [ [ 0, 959 ] ] } ]

[ { "id": "NCT02807857_exc_T2", "type": "Procedure", "text": [ "Major surgery" ], "offsets": [ [ 182, 195 ] ], "normalized": [] }, { "id": "NCT02807857_exc_T3", "type": "Temporal", "text": [ "last 3 months prior to baseline or planned major surgery or cardiac intervention during the study" ], "offsets": [ [ 203, 300 ] ], "normalized": [] }, { "id": "NCT02807857_exc_T4", "type": "Reference_point", "text": [ "baseline or planned major surgery or cardiac intervention during the stud" ], "offsets": [ [ 226, 299 ] ], "normalized": [] }, { "id": "NCT02807857_exc_T5", "type": "Condition", "text": [ "Cancer" ], "offsets": [ [ 302, 308 ] ], "normalized": [] }, { "id": "NCT02807857_exc_T6", "type": "Condition", "text": [ "co-morbidities" ], "offsets": [ [ 330, 344 ] ], "normalized": [] }, { "id": "NCT02807857_exc_T7", "type": "Condition", "text": [ "Comorbidities" ], "offsets": [ [ 396, 409 ] ], "normalized": [] }, { "id": "NCT02807857_exc_T8", "type": "Measurement", "text": [ "riuretic peptide (N", "els: r" ], "offsets": [ [ 450, 469 ], [ 475, 481 ] ], "normalized": [] }, { "id": "NCT02807857_exc_T9", "type": "Measurement", "text": [ "NP" ], "offsets": [ [ 468, 470 ] ], "normalized": [] }, { "id": "NCT02807857_exc_T10", "type": "Value", "text": [ "elevated" ], "offsets": [ [ 438, 446 ] ], "normalized": [] }, { "id": "NCT02807857_exc_T11", "type": "Condition", "text": [ "renal insufficiency" ], "offsets": [ [ 480, 499 ] ], "normalized": [] }, { "id": "NCT02807857_exc_T12", "type": "Measurement", "text": [ "eGFR" ], "offsets": [ [ 502, 506 ] ], "normalized": [] }, { "id": "NCT02807857_exc_T13", "type": "Value", "text": [ "< 25 ml/min/1.73 m²" ], "offsets": [ [ 507, 526 ] ], "normalized": [] }, { "id": "NCT02807857_exc_T14", "type": "Condition", "text": [ "cerebral trauma" ], "offsets": [ [ 594, 609 ] ], "normalized": [] }, { "id": "NCT02807857_exc_T15", "type": "Temporal", "text": [ "less than 3 months" ], "offsets": [ [ 574, 592 ] ], "normalized": [] }, { "id": "NCT02807857_exc_T16", "type": "Condition", "text": [ "cerebrovascular incident" ], "offsets": [ [ 641, 665 ] ], "normalized": [] }, { "id": "NCT02807857_exc_T17", "type": "Temporal", "text": [ "less than 3 months" ], "offsets": [ [ 621, 639 ] ], "normalized": [] }, { "id": "NCT02807857_exc_T18", "type": "Condition", "text": [ "acute exacerbation of COPD" ], "offsets": [ [ 686, 712 ] ], "normalized": [] }, { "id": "NCT02807857_exc_T19", "type": "Temporal", "text": [ "last 3 months" ], "offsets": [ [ 724, 737 ] ], "normalized": [] }, { "id": "NCT02807857_exc_T20", "type": "Scope", "text": [ "renal insufficiency, (eGFR < 25 ml/min/1.73 m² calculated according to MDRD formula), recent (less than 3 months) cerebral trauma or recent (less than 3 months) cerebrovascular incident, novel diagnosis or acute exacerbation of COPD within the last 3 months" ], "offsets": [ [ 480, 737 ] ], "normalized": [] }, { "id": "NCT02807857_exc_T22", "type": "Observation", "text": [ "lifespan" ], "offsets": [ [ 869, 877 ] ], "normalized": [] }, { "id": "NCT02807857_exc_T23", "type": "Temporal", "text": [ "less than 6 months" ], "offsets": [ [ 939, 957 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02807857_exc_R1", "type": "Has_index", "arg1_id": "NCT02807857_exc_T3", "arg2_id": "NCT02807857_exc_T4", "normalized": [] }, { "id": "NCT02807857_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02807857_exc_T2", "arg2_id": "NCT02807857_exc_T3", "normalized": [] }, { "id": "NCT02807857_exc_R3", "type": "Subsumes", "arg1_id": "NCT02807857_exc_T8", "arg2_id": "NCT02807857_exc_T9", "normalized": [] }, { "id": "NCT02807857_exc_R4", "type": "Has_value", "arg1_id": "NCT02807857_exc_T8", "arg2_id": "NCT02807857_exc_T10", "normalized": [] }, { "id": "NCT02807857_exc_R5", "type": "AND", "arg1_id": "NCT02807857_exc_T7", "arg2_id": "NCT02807857_exc_T8", "normalized": [] }, { "id": "NCT02807857_exc_R6", "type": "Has_value", "arg1_id": "NCT02807857_exc_T12", "arg2_id": "NCT02807857_exc_T13", "normalized": [] }, { "id": "NCT02807857_exc_R7", "type": "AND", "arg1_id": "NCT02807857_exc_T11", "arg2_id": "NCT02807857_exc_T12", "normalized": [] }, { "id": "NCT02807857_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02807857_exc_T14", "arg2_id": "NCT02807857_exc_T15", "normalized": [] }, { "id": "NCT02807857_exc_R9", "type": "Has_temporal", "arg1_id": "NCT02807857_exc_T16", "arg2_id": "NCT02807857_exc_T17", "normalized": [] }, { "id": "NCT02807857_exc_R10", "type": "Has_temporal", "arg1_id": "NCT02807857_exc_T18", "arg2_id": "NCT02807857_exc_T19", "normalized": [] }, { "id": "NCT02807857_exc_R11", "type": "Subsumes", "arg1_id": "NCT02807857_exc_T7", "arg2_id": "NCT02807857_exc_T14", "normalized": [] }, { "id": "NCT02807857_exc_R12", "type": "Has_temporal", "arg1_id": "NCT02807857_exc_T22", "arg2_id": "NCT02807857_exc_T23", "normalized": [] } ]

[ { "id": "NCT02807857_inc_text", "type": "inclusion", "text": [ "Willing and able to provide written informed consent and accept study procedures and time schedule.\nAge = 18 years.\nPatients suffering from chronic heart failure (the heart failure diagnosis must have been made or confirmed by a cardiologist and/or hospital physician at any time in the patient's medical history).\nPatients with reduced ejection fraction (= 40%) as confirmed at any time point in the patient's medical history.\n" ], "offsets": [ [ 0, 428 ] ] } ]

[ { "id": "NCT02807857_inc_T2", "type": "Person", "text": [ "Age" ], "offsets": [ [ 100, 103 ] ], "normalized": [] }, { "id": "NCT02807857_inc_T3", "type": "Value", "text": [ "= 18 years" ], "offsets": [ [ 104, 114 ] ], "normalized": [] }, { "id": "NCT02807857_inc_T4", "type": "Condition", "text": [ "chronic heart failure" ], "offsets": [ [ 140, 161 ] ], "normalized": [] }, { "id": "NCT02807857_inc_T5", "type": "Measurement", "text": [ "ejection fraction" ], "offsets": [ [ 337, 354 ] ], "normalized": [] }, { "id": "NCT02807857_inc_T6", "type": "Value", "text": [ "= 40%" ], "offsets": [ [ 356, 361 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02807857_inc_R1", "type": "Has_value", "arg1_id": "NCT02807857_inc_T5", "arg2_id": "NCT02807857_inc_T6", "normalized": [] } ]

[ { "id": "NCT02810704_exc_text", "type": "exclusion", "text": [ "Patients undergoing bilateral hip or knee replacement;\nPatients undergoing total hip or knee replacement who have been enrolled in this study for a prior hip or knee replacement;\nPatients who are concurrently enrolled in another active interventional clinical trial testing a drug or intervention known or believed to interact with aspirin, warfarin, or rivaroxaban;\nPatients who have a contraindication to two or more of the three study prophylaxis regimens;\nWomen who are pregnant or breastfeeding, as well as those of reproductive potential unless there is a negative urine pregnancy test on the day of surgery;\nPatients on chronic (longer than the prior 6 months) anticoagulation other than with antiplatelet medications;\nPatients with documented gastrointestinal, cerebral, or other hemorrhage within 3 months of the operation;\nPatients with a known diagnosis of defective hemostasis and past history of clinical bleeding requiring transfusion and treatment;\nPatients who have had an operative procedure involving the eye, ear, or central nervous system within one month;\nPatients with severe uncontrolled hypertension with systolic BP > 220mmHg or diastolic BP > 120mmHg;\nPatients with an absolute body weight of less than 41 kilograms (90.4 lbs) at baseline visit;\nVulnerable patient populations including prisoners and institutionalized individuals.\n" ], "offsets": [ [ 0, 1358 ] ] } ]

[ { "id": "NCT02810704_exc_T1", "type": "Procedure", "text": [ "knee replacement" ], "offsets": [ [ 37, 53 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T2", "type": "Procedure", "text": [ "hip", "replacement" ], "offsets": [ [ 30, 33 ], [ 42, 53 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T3", "type": "Scope", "text": [ "hip or knee replacement" ], "offsets": [ [ 30, 53 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T4", "type": "Qualifier", "text": [ "bilateral" ], "offsets": [ [ 20, 29 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T5", "type": "Procedure", "text": [ "otal", "nee replacement" ], "offsets": [ [ 76, 80 ], [ 89, 104 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T6", "type": "Procedure", "text": [ "otal hip", "eplacement" ], "offsets": [ [ 76, 84 ], [ 94, 104 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T9", "type": "Condition", "text": [ "contraindication" ], "offsets": [ [ 387, 403 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T12", "type": "Drug", "text": [ "anticoagulation" ], "offsets": [ [ 668, 683 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T13", "type": "Negation", "text": [ "other than" ], "offsets": [ [ 684, 694 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T14", "type": "Drug", "text": [ "antiplatelet" ], "offsets": [ [ 700, 712 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T15", "type": "Temporal", "text": [ "longer than the prior 6 months" ], "offsets": [ [ 636, 666 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T16", "type": "Condition", "text": [ "intestinal, cere", "hage withi" ], "offsets": [ [ 757, 773 ], [ 794, 804 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T17", "type": "Condition", "text": [ "al, or o", "hage withi" ], "offsets": [ [ 775, 783 ], [ 794, 804 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T18", "type": "Condition", "text": [ "hemorrhage" ], "offsets": [ [ 788, 798 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T19", "type": "Temporal", "text": [ "within 3 months of the operation" ], "offsets": [ [ 799, 831 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T20", "type": "Reference_point", "text": [ "operation" ], "offsets": [ [ 822, 831 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T21", "type": "Scope", "text": [ "gastrointestinal, cerebral, or other hemorrhage" ], "offsets": [ [ 751, 798 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T22", "type": "Condition", "text": [ "hemostasis" ], "offsets": [ [ 878, 888 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T23", "type": "Qualifier", "text": [ "defective" ], "offsets": [ [ 868, 877 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T24", "type": "Condition", "text": [ "bleeding" ], "offsets": [ [ 918, 926 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T25", "type": "Procedure", "text": [ "transfusion" ], "offsets": [ [ 937, 948 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T26", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 953, 962 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T27", "type": "Scope", "text": [ "transfusion and treatment" ], "offsets": [ [ 937, 962 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T28", "type": "Procedure", "text": [ "operative procedure" ], "offsets": [ [ 989, 1008 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T29", "type": "Qualifier", "text": [ "eye" ], "offsets": [ [ 1023, 1026 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T30", "type": "Qualifier", "text": [ "ear" ], "offsets": [ [ 1028, 1031 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T31", "type": "Qualifier", "text": [ "central nervous system" ], "offsets": [ [ 1036, 1058 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T32", "type": "Temporal", "text": [ "within one month" ], "offsets": [ [ 1059, 1075 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T33", "type": "Scope", "text": [ "eye, ear, or central nervous system" ], "offsets": [ [ 1023, 1058 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T34", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 1111, 1123 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T35", "type": "Qualifier", "text": [ "uncontrolled" ], "offsets": [ [ 1098, 1110 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T36", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 1091, 1097 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T37", "type": "Measurement", "text": [ "systolic BP" ], "offsets": [ [ 1129, 1140 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T38", "type": "Value", "text": [ "> 220mmHg" ], "offsets": [ [ 1141, 1150 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T39", "type": "Measurement", "text": [ "diastolic BP" ], "offsets": [ [ 1154, 1166 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T40", "type": "Value", "text": [ "> 120mmHg" ], "offsets": [ [ 1167, 1176 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T41", "type": "Scope", "text": [ "systolic BP > 220mmHg or diastolic BP > 120mmHg" ], "offsets": [ [ 1129, 1176 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T42", "type": "Measurement", "text": [ "body weight" ], "offsets": [ [ 1204, 1215 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T44", "type": "Value", "text": [ "less than 41 kilograms" ], "offsets": [ [ 1219, 1241 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T45", "type": "Value", "text": [ "90.4 lbs" ], "offsets": [ [ 1243, 1251 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T43", "type": "Person", "text": [ "prisoners" ], "offsets": [ [ 1313, 1322 ] ], "normalized": [] }, { "id": "NCT02810704_exc_T46", "type": "Visit", "text": [ "institutionalized" ], "offsets": [ [ 1327, 1344 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT02810704_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02810704_exc_T3", "arg2_id": "NCT02810704_exc_T4", "normalized": [] }, { "id": "NCT02810704_exc_R2", "type": "Has_negation", "arg1_id": "NCT02810704_exc_T14", "arg2_id": "NCT02810704_exc_T13", "normalized": [] }, { "id": "NCT02810704_exc_R3", "type": "Has_temporal", "arg1_id": "NCT02810704_exc_T12", "arg2_id": "NCT02810704_exc_T15", "normalized": [] }, { "id": "NCT02810704_exc_R4", "type": "Has_index", "arg1_id": "NCT02810704_exc_T19", "arg2_id": "NCT02810704_exc_T20", "normalized": [] }, { "id": "NCT02810704_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02810704_exc_T21", "arg2_id": "NCT02810704_exc_T19", "normalized": [] }, { "id": "NCT02810704_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02810704_exc_T22", "arg2_id": "NCT02810704_exc_T23", "normalized": [] }, { "id": "NCT02810704_exc_R7", "type": "Has_scope", "arg1_id": "NCT02810704_exc_T24", "arg2_id": "NCT02810704_exc_T27", "normalized": [] }, { "id": "NCT02810704_exc_R8", "type": "Has_scope", "arg1_id": "NCT02810704_exc_T28", "arg2_id": "NCT02810704_exc_T33", "normalized": [] }, { "id": "NCT02810704_exc_R9", "type": "Has_temporal", "arg1_id": "NCT02810704_exc_T28", "arg2_id": "NCT02810704_exc_T32", "normalized": [] }, { "id": "NCT02810704_exc_R10", "type": "Has_value", "arg1_id": "NCT02810704_exc_T37", "arg2_id": "NCT02810704_exc_T38", "normalized": [] }, { "id": "NCT02810704_exc_R11", "type": "Has_value", "arg1_id": "NCT02810704_exc_T39", "arg2_id": "NCT02810704_exc_T40", "normalized": [] }, { "id": "NCT02810704_exc_R12", "type": "Has_qualifier", "arg1_id": "NCT02810704_exc_T34", "arg2_id": "NCT02810704_exc_T35", "normalized": [] }, { "id": "NCT02810704_exc_R13", "type": "Has_qualifier", "arg1_id": "NCT02810704_exc_T34", "arg2_id": "NCT02810704_exc_T36", "normalized": [] }, { "id": "NCT02810704_exc_R14", "type": "Has_scope", "arg1_id": "NCT02810704_exc_T34", "arg2_id": "NCT02810704_exc_T41", "normalized": [] }, { "id": "NCT02810704_exc_R16", "type": "Subsumes", "arg1_id": "NCT02810704_exc_T44", "arg2_id": "NCT02810704_exc_T45", "normalized": [] }, { "id": "NCT02810704_exc_R17", "type": "Has_value", "arg1_id": "NCT02810704_exc_T42", "arg2_id": "NCT02810704_exc_T44", "normalized": [] } ]

[ { "id": "NCT02810704_inc_text", "type": "inclusion", "text": [ "Males and females 21 years of age or older;\nUndergoing elective primary, resurfacing arthroplasty, revision, or second stage re-implantation total hip replacement;\nUndergoing elective primary, revision, or second stage re-implantation total or uni compartmental knee replacement;\nPatient has necessary mental capacity to participate and is able to comply with study protocol requirements;\nPatient is willing and able to give informed consent; and\nPatient is willing to be randomized and participate.\n" ], "offsets": [ [ 0, 500 ] ] } ]

[ { "id": "NCT02810704_inc_T1", "type": "Person", "text": [ "Males" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT02810704_inc_T2", "type": "Person", "text": [ "females" ], "offsets": [ [ 10, 17 ] ], "normalized": [] }, { "id": "NCT02810704_inc_T3", "type": "Person", "text": [ "age" ], "offsets": [ [ 30, 33 ] ], "normalized": [] }, { "id": "NCT02810704_inc_T4", "type": "Value", "text": [ "21 years", "or older" ], "offsets": [ [ 18, 26 ], [ 34, 42 ] ], "normalized": [] }, { "id": "NCT02810704_inc_T5", "type": "Procedure", "text": [ "total hip replacement" ], "offsets": [ [ 141, 162 ] ], "normalized": [] }, { "id": "NCT02810704_inc_T6", "type": "Qualifier", "text": [ "elective" ], "offsets": [ [ 55, 63 ] ], "normalized": [] }, { "id": "NCT02810704_inc_T7", "type": "Qualifier", "text": [ "primary" ], "offsets": [ [ 64, 71 ] ], "normalized": [] }, { "id": "NCT02810704_inc_T8", "type": "Qualifier", "text": [ "revision" ], "offsets": [ [ 99, 107 ] ], "normalized": [] }, { "id": "NCT02810704_inc_T9", "type": "Qualifier", "text": [ "second stage re-implantation" ], "offsets": [ [ 112, 140 ] ], "normalized": [] }, { "id": "NCT02810704_inc_T10", "type": "Qualifier", "text": [ "resurfacing arthroplasty" ], "offsets": [ [ 73, 97 ] ], "normalized": [] }, { "id": "NCT02810704_inc_T11", "type": "Scope", "text": [ "primary, resurfacing arthroplasty, revision, or second stage re-implantation" ], "offsets": [ [ 64, 140 ] ], "normalized": [] }, { "id": "NCT02810704_inc_T12", "type": "Procedure", "text": [ "knee replacement" ], "offsets": [ [ 262, 278 ] ], "normalized": [] }, { "id": "NCT02810704_inc_T13", "type": "Qualifier", "text": [ "uni compartmental" ], "offsets": [ [ 244, 261 ] ], "normalized": [] }, { "id": "NCT02810704_inc_T14", "type": "Qualifier", "text": [ "second stage re-implantation total" ], "offsets": [ [ 206, 240 ] ], "normalized": [] }, { "id": "NCT02810704_inc_T15", "type": "Qualifier", "text": [ "revision" ], "offsets": [ [ 193, 201 ] ], "normalized": [] }, { "id": "NCT02810704_inc_T16", "type": "Qualifier", "text": [ "primary" ], "offsets": [ [ 184, 191 ] ], "normalized": [] }, { "id": "NCT02810704_inc_T17", "type": "Qualifier", "text": [ "elective" ], "offsets": [ [ 175, 183 ] ], "normalized": [] }, { "id": "NCT02810704_inc_T18", "type": "Scope", "text": [ "primary, revision, or second stage re-implantation total or uni compartmental" ], "offsets": [ [ 184, 261 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT02810704_inc_R1", "type": "Has_value", "arg1_id": "NCT02810704_inc_T3", "arg2_id": "NCT02810704_inc_T4", "normalized": [] }, { "id": "NCT02810704_inc_R2", "type": "Has_scope", "arg1_id": "NCT02810704_inc_T5", "arg2_id": "NCT02810704_inc_T11", "normalized": [] }, { "id": "NCT02810704_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT02810704_inc_T5", "arg2_id": "NCT02810704_inc_T6", "normalized": [] }, { "id": "NCT02810704_inc_R4", "type": "Has_scope", "arg1_id": "NCT02810704_inc_T12", "arg2_id": "NCT02810704_inc_T18", "normalized": [] }, { "id": "NCT02810704_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT02810704_inc_T12", "arg2_id": "NCT02810704_inc_T17", "normalized": [] } ]

[ { "id": "NCT02816164_exc_text", "type": "exclusion", "text": [ "Contraindication to Filgrastim\n" ], "offsets": [ [ 0, 31 ] ] } ]

[ { "id": "NCT02816164_exc_T1", "type": "Condition", "text": [ "Contraindication" ], "offsets": [ [ 0, 16 ] ], "normalized": [] }, { "id": "NCT02816164_exc_T2", "type": "Drug", "text": [ "Filgrastim" ], "offsets": [ [ 20, 30 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT02816164_exc_R1", "type": "AND", "arg1_id": "NCT02816164_exc_T1", "arg2_id": "NCT02816164_exc_T2", "normalized": [] } ]

[ { "id": "NCT02816164_inc_text", "type": "inclusion", "text": [ "Histologically confirmed primary breast cancer\nPlanned to start docetaxel component of FEC-D or AC-D, or first cycle of; dose-dense AC-T, TC, FEC-D or TAC chemotherapy\n=19 years of age\nAble to provide verbal consent\n" ], "offsets": [ [ 0, 216 ] ] } ]

[ { "id": "NCT02816164_inc_T1", "type": "Condition", "text": [ "primary breast cancer" ], "offsets": [ [ 25, 46 ] ], "normalized": [] }, { "id": "NCT02816164_inc_T2", "type": "Qualifier", "text": [ "Histologically confirmed" ], "offsets": [ [ 0, 24 ] ], "normalized": [] }, { "id": "NCT02816164_inc_T3", "type": "Procedure", "text": [ "Histologically" ], "offsets": [ [ 0, 14 ] ], "normalized": [] }, { "id": "NCT02816164_inc_T4", "type": "Drug", "text": [ "docetaxel" ], "offsets": [ [ 64, 73 ] ], "normalized": [] }, { "id": "NCT02816164_inc_T5", "type": "Mood", "text": [ "Planned to start" ], "offsets": [ [ 47, 63 ] ], "normalized": [] }, { "id": "NCT02816164_inc_T6", "type": "Procedure", "text": [ "FEC-D" ], "offsets": [ [ 87, 92 ] ], "normalized": [] }, { "id": "NCT02816164_inc_T7", "type": "Procedure", "text": [ "AC-D" ], "offsets": [ [ 96, 100 ] ], "normalized": [] }, { "id": "NCT02816164_inc_T8", "type": "Multiplier", "text": [ "first cycle of" ], "offsets": [ [ 105, 119 ] ], "normalized": [] }, { "id": "NCT02816164_inc_T9", "type": "Procedure", "text": [ "dose-dense AC-T" ], "offsets": [ [ 121, 136 ] ], "normalized": [] }, { "id": "NCT02816164_inc_T10", "type": "Procedure", "text": [ "TC" ], "offsets": [ [ 138, 140 ] ], "normalized": [] }, { "id": "NCT02816164_inc_T11", "type": "Procedure", "text": [ "FEC-D" ], "offsets": [ [ 142, 147 ] ], "normalized": [] }, { "id": "NCT02816164_inc_T12", "type": "Procedure", "text": [ "TAC chemotherapy" ], "offsets": [ [ 151, 167 ] ], "normalized": [] }, { "id": "NCT02816164_inc_T13", "type": "Scope", "text": [ "FEC-D or AC-D" ], "offsets": [ [ 87, 100 ] ], "normalized": [] }, { "id": "NCT02816164_inc_T14", "type": "Scope", "text": [ "irst cycle of;", "ocetaxel" ], "offsets": [ [ 106, 120 ], [ 65, 73 ] ], "normalized": [] }, { "id": "NCT02816164_inc_T15", "type": "Person", "text": [ "age" ], "offsets": [ [ 181, 184 ] ], "normalized": [] }, { "id": "NCT02816164_inc_T16", "type": "Value", "text": [ "=19 years" ], "offsets": [ [ 168, 177 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT02816164_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02816164_inc_T1", "arg2_id": "NCT02816164_inc_T2", "normalized": [] }, { "id": "NCT02816164_inc_R3", "type": "Has_scope", "arg1_id": "NCT02816164_inc_T13", "arg2_id": "NCT02816164_inc_T14", "normalized": [] }, { "id": "NCT02816164_inc_R4", "type": "Has_mood", "arg1_id": "NCT02816164_inc_T13", "arg2_id": "NCT02816164_inc_T5", "normalized": [] }, { "id": "NCT02816164_inc_R5", "type": "Has_value", "arg1_id": "NCT02816164_inc_T15", "arg2_id": "NCT02816164_inc_T16", "normalized": [] } ]

[ { "id": "NCT02816762_exc_text", "type": "exclusion", "text": [ "Non diabetic nephropathy (confirmed by biopsy).\nDialysis for acute renal failure within the 6 previous months.\nEvidence in the clinic history of relevant bilateral stenosis of renal artery (> 75%)\nUrinary albumin/creatinine ratio higher than 3000 mg/g, at the baseline visit.\nSystolic blood pressure = 180 mmHg or diastolic blood pressure = 110 mm Hg at the baseline visit.\nStroke, transient ischemic attack, acute coronary syndrome, or hospitalization for heart failure worsening, within the previous 30 days.\nProfessional drivers, risk profession or respiratory failure.\nSevere daytime sleepiness (Epworth sleepiness scale >18)\nConcomitant treatment with high doses of acetylsalicylic acid (> 500 mg/day) or continuous treatment with non-steroidal anti-inflammatory drugs\nPrevious treatment with CPAP\nParticipation in another clinical trial within the 30 days prior to randomization.\n" ], "offsets": [ [ 0, 886 ] ] } ]

[ { "id": "NCT02816762_exc_T1", "type": "Condition", "text": [ "Non diabetic nephropathy" ], "offsets": [ [ 0, 24 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T2", "type": "Qualifier", "text": [ "confirmed by biopsy" ], "offsets": [ [ 26, 45 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T3", "type": "Procedure", "text": [ "biopsy" ], "offsets": [ [ 39, 45 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T4", "type": "Procedure", "text": [ "Dialysis" ], "offsets": [ [ 48, 56 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T5", "type": "Condition", "text": [ "acute renal failure" ], "offsets": [ [ 61, 80 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T6", "type": "Temporal", "text": [ "within the 6 previous months" ], "offsets": [ [ 81, 109 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T7", "type": "Qualifier", "text": [ "relevant" ], "offsets": [ [ 145, 153 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T8", "type": "Qualifier", "text": [ "bilateral" ], "offsets": [ [ 154, 163 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T9", "type": "Condition", "text": [ "stenosis of renal artery" ], "offsets": [ [ 164, 188 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T10", "type": "Value", "text": [ "> 75%" ], "offsets": [ [ 190, 195 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T11", "type": "Measurement", "text": [ "Urinary albumin/creatinine ratio" ], "offsets": [ [ 197, 229 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T12", "type": "Value", "text": [ "higher than 3000 mg/g" ], "offsets": [ [ 230, 251 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T13", "type": "Temporal", "text": [ "at the baseline visit" ], "offsets": [ [ 253, 274 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T14", "type": "Measurement", "text": [ "Systolic blood pressure" ], "offsets": [ [ 276, 299 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T15", "type": "Value", "text": [ "= 180 mmHg" ], "offsets": [ [ 300, 310 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T16", "type": "Measurement", "text": [ "diastolic blood pressure" ], "offsets": [ [ 314, 338 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T17", "type": "Value", "text": [ "= 110 mm Hg" ], "offsets": [ [ 339, 350 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T18", "type": "Temporal", "text": [ "at the baseline visit" ], "offsets": [ [ 351, 372 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T19", "type": "Scope", "text": [ "Systolic blood pressure = 180 mmHg or diastolic blood pressure = 110 mm Hg" ], "offsets": [ [ 276, 350 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T20", "type": "Condition", "text": [ "Stroke" ], "offsets": [ [ 374, 380 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T21", "type": "Condition", "text": [ "transient ischemic attack" ], "offsets": [ [ 382, 407 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T22", "type": "Condition", "text": [ "acute coronary syndrome" ], "offsets": [ [ 409, 432 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T23", "type": "Procedure", "text": [ "hospitalization" ], "offsets": [ [ 437, 452 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T24", "type": "Condition", "text": [ "heart failure" ], "offsets": [ [ 457, 470 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T25", "type": "Qualifier", "text": [ "worsening" ], "offsets": [ [ 471, 480 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T26", "type": "Temporal", "text": [ "within the previous 30 days" ], "offsets": [ [ 482, 509 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T27", "type": "Scope", "text": [ "Stroke, transient ischemic attack, acute coronary syndrome, or hospitalization for heart failure worsening" ], "offsets": [ [ 374, 480 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T28", "type": "Person", "text": [ "Professional drivers" ], "offsets": [ [ 511, 531 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T29", "type": "Person", "text": [ "risk profession" ], "offsets": [ [ 533, 548 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T30", "type": "Condition", "text": [ "respiratory failure" ], "offsets": [ [ 552, 571 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T31", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 573, 579 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T32", "type": "Condition", "text": [ "daytime sleepiness" ], "offsets": [ [ 580, 598 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T33", "type": "Measurement", "text": [ "Epworth sleepiness scale" ], "offsets": [ [ 600, 624 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T34", "type": "Value", "text": [ ">18" ], "offsets": [ [ 625, 628 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T35", "type": "Scope", "text": [ "Severe daytime sleepiness" ], "offsets": [ [ 573, 598 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T36", "type": "Scope", "text": [ "Epworth sleepiness scale >18" ], "offsets": [ [ 600, 628 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T37", "type": "Temporal", "text": [ "Concomitant" ], "offsets": [ [ 630, 641 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T38", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 642, 651 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T39", "type": "Multiplier", "text": [ "high doses" ], "offsets": [ [ 657, 667 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T40", "type": "Drug", "text": [ "acetylsalicylic acid" ], "offsets": [ [ 671, 691 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T41", "type": "Multiplier", "text": [ "> 500 mg/day" ], "offsets": [ [ 693, 705 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T42", "type": "Temporal", "text": [ "continuous" ], "offsets": [ [ 710, 720 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T43", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 721, 730 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T44", "type": "Drug", "text": [ "non-steroidal anti-inflammatory drugs" ], "offsets": [ [ 736, 773 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T45", "type": "Temporal", "text": [ "Previous" ], "offsets": [ [ 774, 782 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T46", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 783, 792 ] ], "normalized": [] }, { "id": "NCT02816762_exc_T47", "type": "Device", "text": [ "CPAP" ], "offsets": [ [ 798, 802 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02816762_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02816762_exc_T1", "arg2_id": "NCT02816762_exc_T2", "normalized": [] }, { "id": "NCT02816762_exc_R3", "type": "AND", "arg1_id": "NCT02816762_exc_T4", "arg2_id": "NCT02816762_exc_T5", "normalized": [] }, { "id": "NCT02816762_exc_R4", "type": "Has_temporal", "arg1_id": "NCT02816762_exc_T4", "arg2_id": "NCT02816762_exc_T6", "normalized": [] }, { "id": "NCT02816762_exc_R5", "type": "Subsumes", "arg1_id": "NCT02816762_exc_T7", "arg2_id": "NCT02816762_exc_T10", "normalized": [] }, { "id": "NCT02816762_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02816762_exc_T9", "arg2_id": "NCT02816762_exc_T8", "normalized": [] }, { "id": "NCT02816762_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT02816762_exc_T9", "arg2_id": "NCT02816762_exc_T7", "normalized": [] }, { "id": "NCT02816762_exc_R8", "type": "Has_value", "arg1_id": "NCT02816762_exc_T11", "arg2_id": "NCT02816762_exc_T12", "normalized": [] }, { "id": "NCT02816762_exc_R9", "type": "Has_temporal", "arg1_id": "NCT02816762_exc_T11", "arg2_id": "NCT02816762_exc_T13", "normalized": [] }, { "id": "NCT02816762_exc_R10", "type": "Has_value", "arg1_id": "NCT02816762_exc_T14", "arg2_id": "NCT02816762_exc_T15", "normalized": [] }, { "id": "NCT02816762_exc_R11", "type": "Has_value", "arg1_id": "NCT02816762_exc_T16", "arg2_id": "NCT02816762_exc_T17", "normalized": [] }, { "id": "NCT02816762_exc_R12", "type": "Has_temporal", "arg1_id": "NCT02816762_exc_T19", "arg2_id": "NCT02816762_exc_T18", "normalized": [] }, { "id": "NCT02816762_exc_R13", "type": "Has_qualifier", "arg1_id": "NCT02816762_exc_T24", "arg2_id": "NCT02816762_exc_T25", "normalized": [] }, { "id": "NCT02816762_exc_R14", "type": "AND", "arg1_id": "NCT02816762_exc_T23", "arg2_id": "NCT02816762_exc_T24", "normalized": [] }, { "id": "NCT02816762_exc_R15", "type": "Has_temporal", "arg1_id": "NCT02816762_exc_T27", "arg2_id": "NCT02816762_exc_T26", "normalized": [] }, { "id": "NCT02816762_exc_R16", "type": "Has_qualifier", "arg1_id": "NCT02816762_exc_T32", "arg2_id": "NCT02816762_exc_T31", "normalized": [] }, { "id": "NCT02816762_exc_R17", "type": "Has_value", "arg1_id": "NCT02816762_exc_T33", "arg2_id": "NCT02816762_exc_T34", "normalized": [] }, { "id": "NCT02816762_exc_R18", "type": "Subsumes", "arg1_id": "NCT02816762_exc_T35", "arg2_id": "NCT02816762_exc_T36", "normalized": [] }, { "id": "NCT02816762_exc_R19", "type": "Subsumes", "arg1_id": "NCT02816762_exc_T39", "arg2_id": "NCT02816762_exc_T41", "normalized": [] }, { "id": "NCT02816762_exc_R20", "type": "Has_multiplier", "arg1_id": "NCT02816762_exc_T40", "arg2_id": "NCT02816762_exc_T39", "normalized": [] }, { "id": "NCT02816762_exc_R21", "type": "AND", "arg1_id": "NCT02816762_exc_T38", "arg2_id": "NCT02816762_exc_T40", "normalized": [] }, { "id": "NCT02816762_exc_R22", "type": "Has_temporal", "arg1_id": "NCT02816762_exc_T38", "arg2_id": "NCT02816762_exc_T37", "normalized": [] }, { "id": "NCT02816762_exc_R23", "type": "AND", "arg1_id": "NCT02816762_exc_T43", "arg2_id": "NCT02816762_exc_T44", "normalized": [] }, { "id": "NCT02816762_exc_R24", "type": "Has_temporal", "arg1_id": "NCT02816762_exc_T43", "arg2_id": "NCT02816762_exc_T42", "normalized": [] }, { "id": "NCT02816762_exc_R25", "type": "AND", "arg1_id": "NCT02816762_exc_T46", "arg2_id": "NCT02816762_exc_T47", "normalized": [] }, { "id": "NCT02816762_exc_R26", "type": "Has_temporal", "arg1_id": "NCT02816762_exc_T46", "arg2_id": "NCT02816762_exc_T45", "normalized": [] } ]

[ { "id": "NCT02816762_inc_text", "type": "inclusion", "text": [ "Subjects aged 18 to 80 years old\nOverweight or obesity (BMI =25 kg/m2)\nPrevious diagnosis of type 2 diabetes, fulfilling at least one of the following criteria: 1) current treatment with oral antidiabetic drugs and/or insulin; 2) a fasting glucose value above 126 mg/dl on at least 2 occasions; 3) blood glucose level at 2 hours after an oral glucose tolerance test is equal to or more than 200 mg/dl; or 4) a glycated hemoglobin (HbA1c) level > 6.5 %\nClinical diagnosis of diabetic nephropathy, with a urinary albumin/creatinine ratio >30 mg/g and an estimated glomerular filtration rate more than 20 ml/min per 1.73 m2.\nTreatment with stable doses of angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers or anti-aldosterone agents in the last four weeks.\n" ], "offsets": [ [ 0, 779 ] ] } ]

[ { "id": "NCT02816762_inc_T1", "type": "Value", "text": [ "18 to 80 years old" ], "offsets": [ [ 14, 32 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T2", "type": "Person", "text": [ "aged" ], "offsets": [ [ 9, 13 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T3", "type": "Condition", "text": [ "obesity" ], "offsets": [ [ 47, 54 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T4", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 56, 59 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T5", "type": "Value", "text": [ "=25 kg/m2" ], "offsets": [ [ 60, 69 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T6", "type": "Condition", "text": [ "Overweight" ], "offsets": [ [ 33, 43 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T7", "type": "Scope", "text": [ "Overweight or obesity" ], "offsets": [ [ 33, 54 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T8", "type": "Condition", "text": [ "type 2 diabetes" ], "offsets": [ [ 93, 108 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T9", "type": "Multiplier", "text": [ "at least one" ], "offsets": [ [ 121, 133 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T10", "type": "Temporal", "text": [ "Previous" ], "offsets": [ [ 71, 79 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T11", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 164, 171 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T12", "type": "Drug", "text": [ "oral antidiabetic drugs" ], "offsets": [ [ 187, 210 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T13", "type": "Drug", "text": [ "insulin" ], "offsets": [ [ 218, 225 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T14", "type": "Scope", "text": [ "oral antidiabetic drugs and/or insulin" ], "offsets": [ [ 187, 225 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T15", "type": "Measurement", "text": [ "fasting glucose" ], "offsets": [ [ 232, 247 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T16", "type": "Value", "text": [ "above 126 mg/dl" ], "offsets": [ [ 254, 269 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T17", "type": "Multiplier", "text": [ "on at least 2 occasions" ], "offsets": [ [ 270, 293 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T18", "type": "Measurement", "text": [ "blood glucose level" ], "offsets": [ [ 298, 317 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T19", "type": "Value", "text": [ "equal to or more than 200 mg/dl" ], "offsets": [ [ 369, 400 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T20", "type": "Temporal", "text": [ "at 2 hours after an oral glucose tolerance test" ], "offsets": [ [ 318, 365 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T21", "type": "Reference_point", "text": [ "an oral glucose tolerance test" ], "offsets": [ [ 335, 365 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T22", "type": "Procedure", "text": [ "oral glucose tolerance test" ], "offsets": [ [ 338, 365 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T23", "type": "Measurement", "text": [ "glycated hemoglobin (HbA1c) level" ], "offsets": [ [ 410, 443 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T24", "type": "Value", "text": [ "> 6.5 %" ], "offsets": [ [ 444, 451 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T25", "type": "Scope", "text": [ "current treatment with oral antidiabetic drugs and/or insulin; 2) a fasting glucose value above 126 mg/dl on at least 2 occasions; 3) blood glucose level at 2 hours after an oral glucose tolerance test is equal to or more than 200 mg/dl; or 4) a glycated hemoglobin (HbA1c) level > 6.5 %" ], "offsets": [ [ 164, 451 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T26", "type": "Condition", "text": [ "diabetic nephropathy" ], "offsets": [ [ 474, 494 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T27", "type": "Measurement", "text": [ "urinary albumin/creatinine ratio" ], "offsets": [ [ 503, 535 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T28", "type": "Value", "text": [ ">30 mg/g" ], "offsets": [ [ 536, 544 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T29", "type": "Measurement", "text": [ "estimated glomerular filtration rate" ], "offsets": [ [ 552, 588 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T30", "type": "Value", "text": [ "more than 20 ml/min per 1.73 m2" ], "offsets": [ [ 589, 620 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T31", "type": "Drug", "text": [ "angiotensin-converting enzyme inhibitors" ], "offsets": [ [ 653, 693 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T32", "type": "Multiplier", "text": [ "stable doses" ], "offsets": [ [ 637, 649 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T33", "type": "Drug", "text": [ "angiotensin II receptor blockers" ], "offsets": [ [ 695, 727 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T34", "type": "Drug", "text": [ "anti-aldosterone agents" ], "offsets": [ [ 731, 754 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T35", "type": "Temporal", "text": [ "in the last four weeks" ], "offsets": [ [ 755, 777 ] ], "normalized": [] }, { "id": "NCT02816762_inc_T36", "type": "Scope", "text": [ "angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers or anti-aldosterone agents" ], "offsets": [ [ 653, 754 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02816762_inc_R1", "type": "Has_value", "arg1_id": "NCT02816762_inc_T2", "arg2_id": "NCT02816762_inc_T1", "normalized": [] }, { "id": "NCT02816762_inc_R2", "type": "Has_value", "arg1_id": "NCT02816762_inc_T4", "arg2_id": "NCT02816762_inc_T5", "normalized": [] }, { "id": "NCT02816762_inc_R3", "type": "Subsumes", "arg1_id": "NCT02816762_inc_T7", "arg2_id": "NCT02816762_inc_T4", "normalized": [] }, { "id": "NCT02816762_inc_R4", "type": "Has_temporal", "arg1_id": "NCT02816762_inc_T14", "arg2_id": "NCT02816762_inc_T11", "normalized": [] }, { "id": "NCT02816762_inc_R5", "type": "Has_value", "arg1_id": "NCT02816762_inc_T15", "arg2_id": "NCT02816762_inc_T16", "normalized": [] }, { "id": "NCT02816762_inc_R6", "type": "Has_multiplier", "arg1_id": "NCT02816762_inc_T15", "arg2_id": "NCT02816762_inc_T17", "normalized": [] }, { "id": "NCT02816762_inc_R8", "type": "Has_index", "arg1_id": "NCT02816762_inc_T20", "arg2_id": "NCT02816762_inc_T21", "normalized": [] }, { "id": "NCT02816762_inc_R9", "type": "Has_temporal", "arg1_id": "NCT02816762_inc_T18", "arg2_id": "NCT02816762_inc_T20", "normalized": [] }, { "id": "NCT02816762_inc_R10", "type": "Has_value", "arg1_id": "NCT02816762_inc_T18", "arg2_id": "NCT02816762_inc_T19", "normalized": [] }, { "id": "NCT02816762_inc_R11", "type": "Has_value", "arg1_id": "NCT02816762_inc_T23", "arg2_id": "NCT02816762_inc_T24", "normalized": [] }, { "id": "NCT02816762_inc_R12", "type": "Has_temporal", "arg1_id": "NCT02816762_inc_T8", "arg2_id": "NCT02816762_inc_T10", "normalized": [] }, { "id": "NCT02816762_inc_R13", "type": "Has_multiplier", "arg1_id": "NCT02816762_inc_T25", "arg2_id": "NCT02816762_inc_T9", "normalized": [] }, { "id": "NCT02816762_inc_R14", "type": "Has_scope", "arg1_id": "NCT02816762_inc_T8", "arg2_id": "NCT02816762_inc_T25", "normalized": [] }, { "id": "NCT02816762_inc_R15", "type": "Has_value", "arg1_id": "NCT02816762_inc_T27", "arg2_id": "NCT02816762_inc_T28", "normalized": [] }, { "id": "NCT02816762_inc_R16", "type": "Has_value", "arg1_id": "NCT02816762_inc_T29", "arg2_id": "NCT02816762_inc_T30", "normalized": [] }, { "id": "NCT02816762_inc_R17", "type": "Has_multiplier", "arg1_id": "NCT02816762_inc_T36", "arg2_id": "NCT02816762_inc_T32", "normalized": [] }, { "id": "NCT02816762_inc_R18", "type": "Has_temporal", "arg1_id": "NCT02816762_inc_T36", "arg2_id": "NCT02816762_inc_T35", "normalized": [] } ]

[ { "id": "NCT02818816_exc_text", "type": "exclusion", "text": [ "Patients having had an ophthalmic surgical procedure within 6 months of the beginning of the study.\nPatients with a diagnosis of glaucoma\nAny abnormality of the cornea which may prevent reliable applanation tonometry\nKnown allergy/ hypersensitivity reaction to Brimonidine\nContra-indication to Brimonidine including patients on monoamine oxidase inhibitors (MOA)\nPatients unwilling or unable to provide informed consent\nPatients with anticipated difficult airway management (as this may require medications and/or airway manipulations resulting in increased IOP)\n" ], "offsets": [ [ 0, 563 ] ] } ]

[ { "id": "NCT02818816_exc_T1", "type": "Procedure", "text": [ "ophthalmic surgical procedure" ], "offsets": [ [ 23, 52 ] ], "normalized": [] }, { "id": "NCT02818816_exc_T2", "type": "Temporal", "text": [ "within 6 months of the beginning of the study" ], "offsets": [ [ 53, 98 ] ], "normalized": [] }, { "id": "NCT02818816_exc_T3", "type": "Reference_point", "text": [ "study" ], "offsets": [ [ 93, 98 ] ], "normalized": [] }, { "id": "NCT02818816_exc_T4", "type": "Condition", "text": [ "glaucoma" ], "offsets": [ [ 129, 137 ] ], "normalized": [] }, { "id": "NCT02818816_exc_T5", "type": "Condition", "text": [ "abnormality" ], "offsets": [ [ 142, 153 ] ], "normalized": [] }, { "id": "NCT02818816_exc_T6", "type": "Qualifier", "text": [ "cornea" ], "offsets": [ [ 161, 167 ] ], "normalized": [] }, { "id": "NCT02818816_exc_T7", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 223, 230 ] ], "normalized": [] }, { "id": "NCT02818816_exc_T8", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 232, 248 ] ], "normalized": [] }, { "id": "NCT02818816_exc_T9", "type": "Drug", "text": [ "Brimonidine" ], "offsets": [ [ 261, 272 ] ], "normalized": [] }, { "id": "NCT02818816_exc_T10", "type": "Scope", "text": [ "allergy/ hypersensitivity" ], "offsets": [ [ 223, 248 ] ], "normalized": [] }, { "id": "NCT02818816_exc_T11", "type": "Condition", "text": [ "Contra-indication" ], "offsets": [ [ 273, 290 ] ], "normalized": [] }, { "id": "NCT02818816_exc_T12", "type": "Drug", "text": [ "Brimonidine" ], "offsets": [ [ 294, 305 ] ], "normalized": [] }, { "id": "NCT02818816_exc_T13", "type": "Drug", "text": [ "monoamine oxidase inhibitors" ], "offsets": [ [ 328, 356 ] ], "normalized": [] }, { "id": "NCT02818816_exc_T14", "type": "Drug", "text": [ "MOA" ], "offsets": [ [ 358, 361 ] ], "normalized": [] }, { "id": "NCT02818816_exc_T16", "type": "Observation", "text": [ "difficult airway management" ], "offsets": [ [ 446, 473 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02818816_exc_R1", "type": "Has_temporal", "arg1_id": "NCT02818816_exc_T1", "arg2_id": "NCT02818816_exc_T2", "normalized": [] }, { "id": "NCT02818816_exc_R2", "type": "Has_index", "arg1_id": "NCT02818816_exc_T2", "arg2_id": "NCT02818816_exc_T3", "normalized": [] }, { "id": "NCT02818816_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02818816_exc_T5", "arg2_id": "NCT02818816_exc_T6", "normalized": [] }, { "id": "NCT02818816_exc_R4", "type": "AND", "arg1_id": "NCT02818816_exc_T10", "arg2_id": "NCT02818816_exc_T9", "normalized": [] }, { "id": "NCT02818816_exc_R5", "type": "Subsumes", "arg1_id": "NCT02818816_exc_T13", "arg2_id": "NCT02818816_exc_T14", "normalized": [] }, { "id": "NCT02818816_exc_R6", "type": "AND", "arg1_id": "NCT02818816_exc_T11", "arg2_id": "NCT02818816_exc_T12", "normalized": [] }, { "id": "NCT02818816_exc_R7", "type": "Subsumes", "arg1_id": "NCT02818816_exc_T11", "arg2_id": "NCT02818816_exc_T13", "normalized": [] } ]

[ { "id": "NCT02818816_inc_text", "type": "inclusion", "text": [ "Males aged 18 years and above\nPatients with a diagnosis of prostatic carcinoma requiring prostate surgery\n" ], "offsets": [ [ 0, 106 ] ] } ]

[ { "id": "NCT02818816_inc_T1", "type": "Person", "text": [ "Males" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT02818816_inc_T2", "type": "Person", "text": [ "aged" ], "offsets": [ [ 6, 10 ] ], "normalized": [] }, { "id": "NCT02818816_inc_T3", "type": "Value", "text": [ "18 years and above" ], "offsets": [ [ 11, 29 ] ], "normalized": [] }, { "id": "NCT02818816_inc_T4", "type": "Condition", "text": [ "prostatic carcinoma" ], "offsets": [ [ 59, 78 ] ], "normalized": [] }, { "id": "NCT02818816_inc_T5", "type": "Procedure", "text": [ "prostate surgery" ], "offsets": [ [ 89, 105 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02818816_inc_R1", "type": "AND", "arg1_id": "NCT02818816_inc_T4", "arg2_id": "NCT02818816_inc_T5", "normalized": [] }, { "id": "NCT02818816_inc_R2", "type": "Has_value", "arg1_id": "NCT02818816_inc_T2", "arg2_id": "NCT02818816_inc_T3", "normalized": [] } ]

[ { "id": "NCT02821819_exc_text", "type": "exclusion", "text": [ "PCOS patients\nAllergy to gonadotrophins\nConcomitant participation in other trial\n" ], "offsets": [ [ 0, 81 ] ] } ]

[ { "id": "NCT02821819_exc_T1", "type": "Condition", "text": [ "PCOS" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "NCT02821819_exc_T2", "type": "Drug", "text": [ "gonadotrophins" ], "offsets": [ [ 25, 39 ] ], "normalized": [] }, { "id": "NCT02821819_exc_T3", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 14, 21 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02821819_exc_R1", "type": "AND", "arg1_id": "NCT02821819_exc_T3", "arg2_id": "NCT02821819_exc_T2", "normalized": [] } ]

[ { "id": "NCT02821819_inc_text", "type": "inclusion", "text": [ "Premenopausal women\n18-35 years old\nFSH levels < 10 mIU/ml\nAFC> 10\nRegular cycles\nBMI < 28\nSigned informed consent\n" ], "offsets": [ [ 0, 115 ] ] } ]

[ { "id": "NCT02821819_inc_T1", "type": "Person", "text": [ "Premenopausal" ], "offsets": [ [ 0, 13 ] ], "normalized": [] }, { "id": "NCT02821819_inc_T2", "type": "Person", "text": [ "women" ], "offsets": [ [ 14, 19 ] ], "normalized": [] }, { "id": "NCT02821819_inc_T3", "type": "Person", "text": [ "old" ], "offsets": [ [ 32, 35 ] ], "normalized": [] }, { "id": "NCT02821819_inc_T4", "type": "Value", "text": [ "18-35 years" ], "offsets": [ [ 20, 31 ] ], "normalized": [] }, { "id": "NCT02821819_inc_T5", "type": "Measurement", "text": [ "FSH levels" ], "offsets": [ [ 36, 46 ] ], "normalized": [] }, { "id": "NCT02821819_inc_T6", "type": "Value", "text": [ "< 10 mIU/ml" ], "offsets": [ [ 47, 58 ] ], "normalized": [] }, { "id": "NCT02821819_inc_T7", "type": "Measurement", "text": [ "AFC" ], "offsets": [ [ 59, 62 ] ], "normalized": [] }, { "id": "NCT02821819_inc_T8", "type": "Value", "text": [ "> 10" ], "offsets": [ [ 62, 66 ] ], "normalized": [] }, { "id": "NCT02821819_inc_T9", "type": "Condition", "text": [ "Regular cycles" ], "offsets": [ [ 67, 81 ] ], "normalized": [] }, { "id": "NCT02821819_inc_T10", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 82, 85 ] ], "normalized": [] }, { "id": "NCT02821819_inc_T11", "type": "Value", "text": [ "< 28" ], "offsets": [ [ 86, 90 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02821819_inc_R1", "type": "Has_value", "arg1_id": "NCT02821819_inc_T3", "arg2_id": "NCT02821819_inc_T4", "normalized": [] }, { "id": "NCT02821819_inc_R2", "type": "Has_value", "arg1_id": "NCT02821819_inc_T7", "arg2_id": "NCT02821819_inc_T8", "normalized": [] }, { "id": "NCT02821819_inc_R3", "type": "Has_value", "arg1_id": "NCT02821819_inc_T10", "arg2_id": "NCT02821819_inc_T11", "normalized": [] } ]

[ { "id": "NCT02822001_exc_text", "type": "exclusion", "text": [ "Patients unable to give informed consent.\nAny patient whose condition will not allow for placement of the electrode PadSet.\nPatients whose tracheas were not extubated in OR or PACU.\nPatients with Impaired Renal Function with a have a known estimated CrCl<30 ml/min\nPatients using oral contraception.\n" ], "offsets": [ [ 0, 300 ] ] } ]

[ { "id": "NCT02822001_exc_T2", "type": "Condition", "text": [ "condition" ], "offsets": [ [ 60, 69 ] ], "normalized": [] }, { "id": "NCT02822001_exc_T3", "type": "Negation", "text": [ "not" ], "offsets": [ [ 75, 78 ] ], "normalized": [] }, { "id": "NCT02822001_exc_T4", "type": "Mood", "text": [ "allow" ], "offsets": [ [ 79, 84 ] ], "normalized": [] }, { "id": "NCT02822001_exc_T5", "type": "Procedure", "text": [ "placement" ], "offsets": [ [ 89, 98 ] ], "normalized": [] }, { "id": "NCT02822001_exc_T6", "type": "Device", "text": [ "electrode PadSet" ], "offsets": [ [ 106, 122 ] ], "normalized": [] }, { "id": "NCT02822001_exc_T7", "type": "Procedure", "text": [ "extubated" ], "offsets": [ [ 157, 166 ] ], "normalized": [] }, { "id": "NCT02822001_exc_T8", "type": "Qualifier", "text": [ "tracheas" ], "offsets": [ [ 139, 147 ] ], "normalized": [] }, { "id": "NCT02822001_exc_T9", "type": "Negation", "text": [ "not" ], "offsets": [ [ 153, 156 ] ], "normalized": [] }, { "id": "NCT02822001_exc_T10", "type": "Visit", "text": [ "OR" ], "offsets": [ [ 170, 172 ] ], "normalized": [] }, { "id": "NCT02822001_exc_T11", "type": "Visit", "text": [ "PACU" ], "offsets": [ [ 176, 180 ] ], "normalized": [] }, { "id": "NCT02822001_exc_T12", "type": "Scope", "text": [ "OR or PACU" ], "offsets": [ [ 170, 180 ] ], "normalized": [] }, { "id": "NCT02822001_exc_T13", "type": "Condition", "text": [ "Impaired Renal Function" ], "offsets": [ [ 196, 219 ] ], "normalized": [] }, { "id": "NCT02822001_exc_T14", "type": "Measurement", "text": [ "estimated CrCl" ], "offsets": [ [ 240, 254 ] ], "normalized": [] }, { "id": "NCT02822001_exc_T15", "type": "Value", "text": [ "<30 ml/min" ], "offsets": [ [ 254, 264 ] ], "normalized": [] }, { "id": "NCT02822001_exc_T16", "type": "Procedure", "text": [ "oral contraception" ], "offsets": [ [ 280, 298 ] ], "normalized": [] }, { "id": "NCT02822001_exc_T17", "type": "Drug", "text": [ "oral contraception" ], "offsets": [ [ 280, 298 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02822001_exc_R1", "type": "AND", "arg1_id": "NCT02822001_exc_T5", "arg2_id": "NCT02822001_exc_T6", "normalized": [] }, { "id": "NCT02822001_exc_R2", "type": "Has_mood", "arg1_id": "NCT02822001_exc_T5", "arg2_id": "NCT02822001_exc_T4", "normalized": [] }, { "id": "NCT02822001_exc_R3", "type": "Has_negation", "arg1_id": "NCT02822001_exc_T4", "arg2_id": "NCT02822001_exc_T3", "normalized": [] }, { "id": "NCT02822001_exc_R4", "type": "AND", "arg1_id": "NCT02822001_exc_T2", "arg2_id": "NCT02822001_exc_T5", "normalized": [] }, { "id": "NCT02822001_exc_R5", "type": "Has_negation", "arg1_id": "NCT02822001_exc_T7", "arg2_id": "NCT02822001_exc_T9", "normalized": [] }, { "id": "NCT02822001_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02822001_exc_T7", "arg2_id": "NCT02822001_exc_T8", "normalized": [] }, { "id": "NCT02822001_exc_R7", "type": "Has_scope", "arg1_id": "NCT02822001_exc_T7", "arg2_id": "NCT02822001_exc_T12", "normalized": [] }, { "id": "NCT02822001_exc_R8", "type": "Has_value", "arg1_id": "NCT02822001_exc_T14", "arg2_id": "NCT02822001_exc_T15", "normalized": [] } ]

[ { "id": "NCT02822001_inc_text", "type": "inclusion", "text": [ "Patients undergoing surgery with general anesthesia,\nPatients weighing = 80 pounds who are not -intubated prior to surgery,\nPatients who are able to give informed consent.\n" ], "offsets": [ [ 0, 172 ] ] } ]

[ { "id": "NCT02822001_inc_T1", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 20, 27 ] ], "normalized": [] }, { "id": "NCT02822001_inc_T2", "type": "Temporal", "text": [ "undergoing" ], "offsets": [ [ 9, 19 ] ], "normalized": [] }, { "id": "NCT02822001_inc_T3", "type": "Qualifier", "text": [ "general anesthesia" ], "offsets": [ [ 33, 51 ] ], "normalized": [] }, { "id": "NCT02822001_inc_T4", "type": "Procedure", "text": [ "general anesthesia" ], "offsets": [ [ 33, 51 ] ], "normalized": [] }, { "id": "NCT02822001_inc_T5", "type": "Measurement", "text": [ "weighing" ], "offsets": [ [ 62, 70 ] ], "normalized": [] }, { "id": "NCT02822001_inc_T6", "type": "Value", "text": [ "= 80 pounds" ], "offsets": [ [ 71, 82 ] ], "normalized": [] }, { "id": "NCT02822001_inc_T7", "type": "Negation", "text": [ "not" ], "offsets": [ [ 91, 94 ] ], "normalized": [] }, { "id": "NCT02822001_inc_T8", "type": "Procedure", "text": [ "intubated" ], "offsets": [ [ 96, 105 ] ], "normalized": [] }, { "id": "NCT02822001_inc_T9", "type": "Temporal", "text": [ "prior to surgery" ], "offsets": [ [ 106, 122 ] ], "normalized": [] }, { "id": "NCT02822001_inc_T10", "type": "Reference_point", "text": [ "surgery" ], "offsets": [ [ 115, 122 ] ], "normalized": [] }, { "id": "NCT02822001_inc_T11", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 115, 122 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02822001_inc_R1", "type": "Has_temporal", "arg1_id": "NCT02822001_inc_T1", "arg2_id": "NCT02822001_inc_T2", "normalized": [] }, { "id": "NCT02822001_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02822001_inc_T1", "arg2_id": "NCT02822001_inc_T3", "normalized": [] }, { "id": "NCT02822001_inc_R5", "type": "Has_index", "arg1_id": "NCT02822001_inc_T9", "arg2_id": "NCT02822001_inc_T10", "normalized": [] }, { "id": "NCT02822001_inc_R6", "type": "Has_temporal", "arg1_id": "NCT02822001_inc_T8", "arg2_id": "NCT02822001_inc_T9", "normalized": [] }, { "id": "NCT02822001_inc_R7", "type": "Has_negation", "arg1_id": "NCT02822001_inc_T8", "arg2_id": "NCT02822001_inc_T7", "normalized": [] }, { "id": "NCT02822001_inc_R8", "type": "Has_value", "arg1_id": "NCT02822001_inc_T5", "arg2_id": "NCT02822001_inc_T6", "normalized": [] } ]

[ { "id": "NCT02823808_exc_text", "type": "exclusion", "text": [ "The use of weight-lowering drugs, any investigational blood-glucose or lipid-lowering agent (other than statins or ezetimibe) within the past 3 months\nPrevious treatment with systemic corticosteroids or a change in dosage of thyroid hormones in the previous 6 weeks\nThe use of insulin within the 3 months prior to screening\nOthers\n" ], "offsets": [ [ 0, 331 ] ] } ]

[ { "id": "NCT02823808_exc_T1", "type": "Qualifier", "text": [ "weight-lowering" ], "offsets": [ [ 11, 26 ] ], "normalized": [] }, { "id": "NCT02823808_exc_T2", "type": "Drug", "text": [ "drugs" ], "offsets": [ [ 27, 32 ] ], "normalized": [] }, { "id": "NCT02823808_exc_T3", "type": "Qualifier", "text": [ "investigational" ], "offsets": [ [ 38, 53 ] ], "normalized": [] }, { "id": "NCT02823808_exc_T4", "type": "Qualifier", "text": [ "lipid-lowering" ], "offsets": [ [ 71, 85 ] ], "normalized": [] }, { "id": "NCT02823808_exc_T5", "type": "Qualifier", "text": [ "blood-glucose" ], "offsets": [ [ 54, 67 ] ], "normalized": [] }, { "id": "NCT02823808_exc_T6", "type": "Drug", "text": [ "agent" ], "offsets": [ [ 86, 91 ] ], "normalized": [] }, { "id": "NCT02823808_exc_T7", "type": "Scope", "text": [ "blood-glucose or lipid-lowering" ], "offsets": [ [ 54, 85 ] ], "normalized": [] }, { "id": "NCT02823808_exc_T8", "type": "Temporal", "text": [ "past 3 months" ], "offsets": [ [ 137, 150 ] ], "normalized": [] }, { "id": "NCT02823808_exc_T9", "type": "Negation", "text": [ "other" ], "offsets": [ [ 93, 98 ] ], "normalized": [] }, { "id": "NCT02823808_exc_T10", "type": "Drug", "text": [ "statins" ], "offsets": [ [ 104, 111 ] ], "normalized": [] }, { "id": "NCT02823808_exc_T11", "type": "Drug", "text": [ "ezetimibe" ], "offsets": [ [ 115, 124 ] ], "normalized": [] }, { "id": "NCT02823808_exc_T12", "type": "Scope", "text": [ "statins or ezetimibe" ], "offsets": [ [ 104, 124 ] ], "normalized": [] }, { "id": "NCT02823808_exc_T13", "type": "Scope", "text": [ "weight-lowering drugs, any investigational blood-glucose or lipid-lowering agent" ], "offsets": [ [ 11, 91 ] ], "normalized": [] }, { "id": "NCT02823808_exc_T14", "type": "Drug", "text": [ "systemic corticosteroids" ], "offsets": [ [ 175, 199 ] ], "normalized": [] }, { "id": "NCT02823808_exc_T15", "type": "Drug", "text": [ "thyroid hormones" ], "offsets": [ [ 225, 241 ] ], "normalized": [] }, { "id": "NCT02823808_exc_T16", "type": "Qualifier", "text": [ "change in dosage" ], "offsets": [ [ 205, 221 ] ], "normalized": [] }, { "id": "NCT02823808_exc_T17", "type": "Temporal", "text": [ "previous 6 weeks" ], "offsets": [ [ 249, 265 ] ], "normalized": [] }, { "id": "NCT02823808_exc_T18", "type": "Scope", "text": [ "systemic corticosteroids or a change in dosage of thyroid hormones" ], "offsets": [ [ 175, 241 ] ], "normalized": [] }, { "id": "NCT02823808_exc_T19", "type": "Drug", "text": [ "insulin" ], "offsets": [ [ 277, 284 ] ], "normalized": [] }, { "id": "NCT02823808_exc_T20", "type": "Temporal", "text": [ "within the 3 months prior to screening" ], "offsets": [ [ 285, 323 ] ], "normalized": [] }, { "id": "NCT02823808_exc_T21", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 314, 323 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02823808_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02823808_exc_T2", "arg2_id": "NCT02823808_exc_T1", "normalized": [] }, { "id": "NCT02823808_exc_R2", "type": "Has_scope", "arg1_id": "NCT02823808_exc_T6", "arg2_id": "NCT02823808_exc_T7", "normalized": [] }, { "id": "NCT02823808_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02823808_exc_T6", "arg2_id": "NCT02823808_exc_T3", "normalized": [] }, { "id": "NCT02823808_exc_R4", "type": "Has_negation", "arg1_id": "NCT02823808_exc_T12", "arg2_id": "NCT02823808_exc_T9", "normalized": [] }, { "id": "NCT02823808_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02823808_exc_T13", "arg2_id": "NCT02823808_exc_T8", "normalized": [] }, { "id": "NCT02823808_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02823808_exc_T15", "arg2_id": "NCT02823808_exc_T16", "normalized": [] }, { "id": "NCT02823808_exc_R7", "type": "Has_temporal", "arg1_id": "NCT02823808_exc_T18", "arg2_id": "NCT02823808_exc_T17", "normalized": [] }, { "id": "NCT02823808_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02823808_exc_T19", "arg2_id": "NCT02823808_exc_T20", "normalized": [] }, { "id": "NCT02823808_exc_R9", "type": "Has_index", "arg1_id": "NCT02823808_exc_T20", "arg2_id": "NCT02823808_exc_T21", "normalized": [] } ]

[ { "id": "NCT02823808_inc_text", "type": "inclusion", "text": [ "Type 2 Diabetes Mellitus patients\nPatient who had been diagnosed within the previous 12 months with HbA1c levels of 8.0-12.0%, did not have a medical history related to diabetes, and did not display proliferative retinopathy\n" ], "offsets": [ [ 0, 225 ] ] } ]

[ { "id": "NCT02823808_inc_T1", "type": "Condition", "text": [ "Type 2 Diabetes Mellitus" ], "offsets": [ [ 0, 24 ] ], "normalized": [] }, { "id": "NCT02823808_inc_T2", "type": "Measurement", "text": [ "HbA1c" ], "offsets": [ [ 100, 105 ] ], "normalized": [] }, { "id": "NCT02823808_inc_T3", "type": "Value", "text": [ "8.0-12.0%" ], "offsets": [ [ 116, 125 ] ], "normalized": [] }, { "id": "NCT02823808_inc_T4", "type": "Temporal", "text": [ "previous 12 months" ], "offsets": [ [ 76, 94 ] ], "normalized": [] }, { "id": "NCT02823808_inc_T5", "type": "Negation", "text": [ "not" ], "offsets": [ [ 187, 190 ] ], "normalized": [] }, { "id": "NCT02823808_inc_T6", "type": "Condition", "text": [ "proliferative retinopathy" ], "offsets": [ [ 199, 224 ] ], "normalized": [] }, { "id": "NCT02823808_inc_T7", "type": "Negation", "text": [ "not" ], "offsets": [ [ 131, 134 ] ], "normalized": [] }, { "id": "NCT02823808_inc_T8", "type": "Observation", "text": [ "medical history related to diabetes" ], "offsets": [ [ 142, 177 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT02823808_inc_R1", "type": "Has_value", "arg1_id": "NCT02823808_inc_T2", "arg2_id": "NCT02823808_inc_T3", "normalized": [] }, { "id": "NCT02823808_inc_R2", "type": "Has_temporal", "arg1_id": "NCT02823808_inc_T2", "arg2_id": "NCT02823808_inc_T4", "normalized": [] }, { "id": "NCT02823808_inc_R3", "type": "Has_negation", "arg1_id": "NCT02823808_inc_T6", "arg2_id": "NCT02823808_inc_T5", "normalized": [] }, { "id": "NCT02823808_inc_R4", "type": "Has_negation", "arg1_id": "NCT02823808_inc_T8", "arg2_id": "NCT02823808_inc_T7", "normalized": [] } ]

[ { "id": "NCT02825290_exc_text", "type": "exclusion", "text": [ "PGD patients\nMore than 4 previous embryo transfers\n" ], "offsets": [ [ 0, 51 ] ] } ]

[ { "id": "NCT02825290_exc_T1", "type": "Procedure", "text": [ "PGD" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02825290_exc_T2", "type": "Multiplier", "text": [ "More than 4" ], "offsets": [ [ 13, 24 ] ], "normalized": [] }, { "id": "NCT02825290_exc_T3", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 25, 33 ] ], "normalized": [] }, { "id": "NCT02825290_exc_T4", "type": "Procedure", "text": [ "embryo transfers" ], "offsets": [ [ 34, 50 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02825290_exc_R1", "type": "Has_temporal", "arg1_id": "NCT02825290_exc_T4", "arg2_id": "NCT02825290_exc_T3", "normalized": [] }, { "id": "NCT02825290_exc_R2", "type": "Has_multiplier", "arg1_id": "NCT02825290_exc_T4", "arg2_id": "NCT02825290_exc_T2", "normalized": [] } ]

[ { "id": "NCT02825290_inc_text", "type": "inclusion", "text": [ "20-40 years old women\nSpontaneously ovulating women\nTreated in our IVF unit for frozen-thawed embryo transfer\nAt least one top quality embryo\n" ], "offsets": [ [ 0, 142 ] ] } ]

[ { "id": "NCT02825290_inc_T1", "type": "Value", "text": [ "20-40 years" ], "offsets": [ [ 0, 11 ] ], "normalized": [] }, { "id": "NCT02825290_inc_T2", "type": "Person", "text": [ "old" ], "offsets": [ [ 12, 15 ] ], "normalized": [] }, { "id": "NCT02825290_inc_T3", "type": "Person", "text": [ "women" ], "offsets": [ [ 16, 21 ] ], "normalized": [] }, { "id": "NCT02825290_inc_T4", "type": "Condition", "text": [ "Spontaneously ovulating" ], "offsets": [ [ 22, 45 ] ], "normalized": [] }, { "id": "NCT02825290_inc_T5", "type": "Person", "text": [ "women" ], "offsets": [ [ 46, 51 ] ], "normalized": [] }, { "id": "NCT02825290_inc_T6", "type": "Visit", "text": [ "our IVF unit" ], "offsets": [ [ 63, 75 ] ], "normalized": [] }, { "id": "NCT02825290_inc_T7", "type": "Procedure", "text": [ "frozen-thawed embryo transfer" ], "offsets": [ [ 80, 109 ] ], "normalized": [] }, { "id": "NCT02825290_inc_T8", "type": "Value", "text": [ "At least one" ], "offsets": [ [ 110, 122 ] ], "normalized": [] }, { "id": "NCT02825290_inc_T9", "type": "Measurement", "text": [ "top quality embryo" ], "offsets": [ [ 123, 141 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02825290_inc_R1", "type": "Has_value", "arg1_id": "NCT02825290_inc_T2", "arg2_id": "NCT02825290_inc_T1", "normalized": [] }, { "id": "NCT02825290_inc_R2", "type": "Has_value", "arg1_id": "NCT02825290_inc_T9", "arg2_id": "NCT02825290_inc_T8", "normalized": [] } ]

[ { "id": "NCT02827487_exc_text", "type": "exclusion", "text": [ "Previous vaginal delivery.\nSubmucous myoma.\nUterine anomalies.\nUndiagnosed vaginal bleeding.\nPelvic inflammatory disease.\n" ], "offsets": [ [ 0, 122 ] ] } ]

[ { "id": "NCT02827487_exc_T1", "type": "Procedure", "text": [ "vaginal delivery" ], "offsets": [ [ 9, 25 ] ], "normalized": [] }, { "id": "NCT02827487_exc_T2", "type": "Temporal", "text": [ "Previous" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT02827487_exc_T3", "type": "Condition", "text": [ "Submucous myoma" ], "offsets": [ [ 27, 42 ] ], "normalized": [] }, { "id": "NCT02827487_exc_T4", "type": "Condition", "text": [ "Uterine anomalies" ], "offsets": [ [ 44, 61 ] ], "normalized": [] }, { "id": "NCT02827487_exc_T5", "type": "Condition", "text": [ "vaginal bleeding" ], "offsets": [ [ 75, 91 ] ], "normalized": [] }, { "id": "NCT02827487_exc_T6", "type": "Qualifier", "text": [ "Undiagnosed" ], "offsets": [ [ 63, 74 ] ], "normalized": [] }, { "id": "NCT02827487_exc_T7", "type": "Condition", "text": [ "Pelvic inflammatory disease" ], "offsets": [ [ 93, 120 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02827487_exc_R1", "type": "Has_temporal", "arg1_id": "NCT02827487_exc_T1", "arg2_id": "NCT02827487_exc_T2", "normalized": [] }, { "id": "NCT02827487_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02827487_exc_T5", "arg2_id": "NCT02827487_exc_T6", "normalized": [] } ]

[ { "id": "NCT02827487_inc_text", "type": "inclusion", "text": [ "Women with expected difficult IUD insertion like nulliparous women and women with previous cesarean section.\n" ], "offsets": [ [ 0, 109 ] ] } ]

[ { "id": "NCT02827487_inc_T1", "type": "Person", "text": [ "Women" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT02827487_inc_T2", "type": "Mood", "text": [ "expected" ], "offsets": [ [ 11, 19 ] ], "normalized": [] }, { "id": "NCT02827487_inc_T3", "type": "Qualifier", "text": [ "difficult" ], "offsets": [ [ 20, 29 ] ], "normalized": [] }, { "id": "NCT02827487_inc_T4", "type": "Procedure", "text": [ "IUD insertion" ], "offsets": [ [ 30, 43 ] ], "normalized": [] }, { "id": "NCT02827487_inc_T5", "type": "Observation", "text": [ "nulliparous" ], "offsets": [ [ 49, 60 ] ], "normalized": [] }, { "id": "NCT02827487_inc_T6", "type": "Person", "text": [ "women" ], "offsets": [ [ 61, 66 ] ], "normalized": [] }, { "id": "NCT02827487_inc_T7", "type": "Person", "text": [ "women" ], "offsets": [ [ 71, 76 ] ], "normalized": [] }, { "id": "NCT02827487_inc_T8", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 82, 90 ] ], "normalized": [] }, { "id": "NCT02827487_inc_T9", "type": "Procedure", "text": [ "cesarean section" ], "offsets": [ [ 91, 107 ] ], "normalized": [] }, { "id": "NCT02827487_inc_T10", "type": "Scope", "text": [ "nulliparous women" ], "offsets": [ [ 49, 66 ] ], "normalized": [] }, { "id": "NCT02827487_inc_T11", "type": "Scope", "text": [ "women with previous cesarean section" ], "offsets": [ [ 71, 107 ] ], "normalized": [] }, { "id": "NCT02827487_inc_T12", "type": "Scope", "text": [ "nulliparous women and women with previous cesarean section" ], "offsets": [ [ 49, 107 ] ], "normalized": [] }, { "id": "NCT02827487_inc_T13", "type": "Scope", "text": [ "expected difficult IUD insertion" ], "offsets": [ [ 11, 43 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT02827487_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT02827487_inc_T4", "arg2_id": "NCT02827487_inc_T3", "normalized": [] }, { "id": "NCT02827487_inc_R2", "type": "Has_mood", "arg1_id": "NCT02827487_inc_T4", "arg2_id": "NCT02827487_inc_T2", "normalized": [] }, { "id": "NCT02827487_inc_R3", "type": "Has_temporal", "arg1_id": "NCT02827487_inc_T9", "arg2_id": "NCT02827487_inc_T8", "normalized": [] }, { "id": "NCT02827487_inc_R4", "type": "Subsumes", "arg1_id": "NCT02827487_inc_T13", "arg2_id": "NCT02827487_inc_T12", "normalized": [] } ]

[ { "id": "NCT02827526_exc_text", "type": "exclusion", "text": [ "Preoperative renal failure (defined as a serum creatinine > 2.0 mg/dL.)\nAmerican Society of Anesthesiologists Physical Status IV or V\nPulmonary disease necessitating home oxygen therapy\nAllergy to methadone, hydromorphone, or ketamine\nPreoperative recent history of opioid or alcohol abuse\nSignificant liver disease\nInability to use a PCA device or speak the English language\n" ], "offsets": [ [ 0, 376 ] ] } ]

[ { "id": "NCT02827526_exc_T1", "type": "Temporal", "text": [ "Preoperative" ], "offsets": [ [ 0, 12 ] ], "normalized": [] }, { "id": "NCT02827526_exc_T2", "type": "Condition", "text": [ "renal failure" ], "offsets": [ [ 13, 26 ] ], "normalized": [] }, { "id": "NCT02827526_exc_T3", "type": "Measurement", "text": [ "serum creatinine" ], "offsets": [ [ 41, 57 ] ], "normalized": [] }, { "id": "NCT02827526_exc_T4", "type": "Value", "text": [ "> 2.0 mg/dL" ], "offsets": [ [ 58, 69 ] ], "normalized": [] }, { "id": "NCT02827526_exc_T5", "type": "Scope", "text": [ "serum creatinine > 2.0 mg/dL" ], "offsets": [ [ 41, 69 ] ], "normalized": [] }, { "id": "NCT02827526_exc_T6", "type": "Measurement", "text": [ "American Society of Anesthesiologists Physical Status" ], "offsets": [ [ 72, 125 ] ], "normalized": [] }, { "id": "NCT02827526_exc_T7", "type": "Value", "text": [ "IV or V" ], "offsets": [ [ 126, 133 ] ], "normalized": [] }, { "id": "NCT02827526_exc_T8", "type": "Condition", "text": [ "Pulmonary disease" ], "offsets": [ [ 134, 151 ] ], "normalized": [] }, { "id": "NCT02827526_exc_T9", "type": "Procedure", "text": [ "home oxygen therapy" ], "offsets": [ [ 166, 185 ] ], "normalized": [] }, { "id": "NCT02827526_exc_T10", "type": "Drug", "text": [ "methadone" ], "offsets": [ [ 197, 206 ] ], "normalized": [] }, { "id": "NCT02827526_exc_T11", "type": "Drug", "text": [ "hydromorphone" ], "offsets": [ [ 208, 221 ] ], "normalized": [] }, { "id": "NCT02827526_exc_T12", "type": "Drug", "text": [ "ketamine" ], "offsets": [ [ 226, 234 ] ], "normalized": [] }, { "id": "NCT02827526_exc_T13", "type": "Temporal", "text": [ "Preoperative" ], "offsets": [ [ 235, 247 ] ], "normalized": [] }, { "id": "NCT02827526_exc_T14", "type": "Temporal", "text": [ "recent" ], "offsets": [ [ 248, 254 ] ], "normalized": [] }, { "id": "NCT02827526_exc_T15", "type": "Observation", "text": [ "history" ], "offsets": [ [ 255, 262 ] ], "normalized": [] }, { "id": "NCT02827526_exc_T16", "type": "Condition", "text": [ "alcohol abuse" ], "offsets": [ [ 276, 289 ] ], "normalized": [] }, { "id": "NCT02827526_exc_T17", "type": "Condition", "text": [ "id or", "e\nSig" ], "offsets": [ [ 270, 275 ], [ 288, 293 ] ], "normalized": [] }, { "id": "NCT02827526_exc_T18", "type": "Scope", "text": [ "opioid or alcohol abuse" ], "offsets": [ [ 266, 289 ] ], "normalized": [] }, { "id": "NCT02827526_exc_T19", "type": "Qualifier", "text": [ "Significant" ], "offsets": [ [ 290, 301 ] ], "normalized": [] }, { "id": "NCT02827526_exc_T20", "type": "Condition", "text": [ "liver disease" ], "offsets": [ [ 302, 315 ] ], "normalized": [] }, { "id": "NCT02827526_exc_T21", "type": "Device", "text": [ "PCA device" ], "offsets": [ [ 335, 345 ] ], "normalized": [] }, { "id": "NCT02827526_exc_T22", "type": "Observation", "text": [ "Inability to use" ], "offsets": [ [ 316, 332 ] ], "normalized": [] }, { "id": "NCT02827526_exc_T23", "type": "Observation", "text": [ "ity to use a", "the English language" ], "offsets": [ [ 322, 334 ], [ 355, 375 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02827526_exc_R1", "type": "Has_temporal", "arg1_id": "NCT02827526_exc_T2", "arg2_id": "NCT02827526_exc_T1", "normalized": [] }, { "id": "NCT02827526_exc_R2", "type": "Has_value", "arg1_id": "NCT02827526_exc_T3", "arg2_id": "NCT02827526_exc_T4", "normalized": [] }, { "id": "NCT02827526_exc_R3", "type": "Subsumes", "arg1_id": "NCT02827526_exc_T2", "arg2_id": "NCT02827526_exc_T5", "normalized": [] }, { "id": "NCT02827526_exc_R4", "type": "Has_value", "arg1_id": "NCT02827526_exc_T6", "arg2_id": "NCT02827526_exc_T7", "normalized": [] }, { "id": "NCT02827526_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02827526_exc_T18", "arg2_id": "NCT02827526_exc_T15", "normalized": [] }, { "id": "NCT02827526_exc_R6", "type": "Has_temporal", "arg1_id": "NCT02827526_exc_T18", "arg2_id": "NCT02827526_exc_T14", "normalized": [] }, { "id": "NCT02827526_exc_R7", "type": "Has_temporal", "arg1_id": "NCT02827526_exc_T18", "arg2_id": "NCT02827526_exc_T13", "normalized": [] }, { "id": "NCT02827526_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT02827526_exc_T20", "arg2_id": "NCT02827526_exc_T19", "normalized": [] }, { "id": "NCT02827526_exc_R9", "type": "AND", "arg1_id": "NCT02827526_exc_T22", "arg2_id": "NCT02827526_exc_T21", "normalized": [] } ]

[ { "id": "NCT02827526_inc_text", "type": "inclusion", "text": [ "Patients presenting for elective posterior spinal fusion surgery (lower thoracic, lumbar, sacral)\nAges 18-80\n" ], "offsets": [ [ 0, 109 ] ] } ]

[ { "id": "NCT02827526_inc_T1", "type": "Procedure", "text": [ "posterior spinal fusion surgery" ], "offsets": [ [ 33, 64 ] ], "normalized": [] }, { "id": "NCT02827526_inc_T2", "type": "Qualifier", "text": [ "elective" ], "offsets": [ [ 24, 32 ] ], "normalized": [] }, { "id": "NCT02827526_inc_T3", "type": "Qualifier", "text": [ "lower thoracic" ], "offsets": [ [ 66, 80 ] ], "normalized": [] }, { "id": "NCT02827526_inc_T4", "type": "Qualifier", "text": [ "lumbar" ], "offsets": [ [ 82, 88 ] ], "normalized": [] }, { "id": "NCT02827526_inc_T5", "type": "Qualifier", "text": [ "sacral" ], "offsets": [ [ 90, 96 ] ], "normalized": [] }, { "id": "NCT02827526_inc_T6", "type": "Scope", "text": [ "lower thoracic, lumbar, sacral" ], "offsets": [ [ 66, 96 ] ], "normalized": [] }, { "id": "NCT02827526_inc_T7", "type": "Person", "text": [ "Ages" ], "offsets": [ [ 98, 102 ] ], "normalized": [] }, { "id": "NCT02827526_inc_T8", "type": "Value", "text": [ "18-80" ], "offsets": [ [ 103, 108 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02827526_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT02827526_inc_T1", "arg2_id": "NCT02827526_inc_T2", "normalized": [] }, { "id": "NCT02827526_inc_R2", "type": "Has_scope", "arg1_id": "NCT02827526_inc_T1", "arg2_id": "NCT02827526_inc_T6", "normalized": [] }, { "id": "NCT02827526_inc_R3", "type": "Has_value", "arg1_id": "NCT02827526_inc_T7", "arg2_id": "NCT02827526_inc_T8", "normalized": [] } ]

[ { "id": "NCT02830360_exc_text", "type": "exclusion", "text": [ "Unable or unwilling to provide informed consent.\nActive ischemia (acute thrombus diagnosed by coronary angiography, or dynamic ST segment changes demonstrated on ECG) or another reversible cause of VT (e.g. drug-induced arrhythmia), had recent acute coronary syndrome within 30 days, coronary revascularization (<90 days bypass surgery, <30 days percutaneous coronary intervention), or have CCS functional class IV angina. Note that biomarker level elevation alone after ventricular arrhythmias does not denote acute coronary syndrome or active ischemia.\nAre ineligible to take the antiarrhythmic drug to which they would be assigned due to allergy, intolerance or contraindication\nAre known to have protruding left ventricular thrombus or mechanical aortic and mitral valves\nHave had a prior catheter ablation procedure for VT\nAre in renal failure (Creatinine clearance <15 mL/min), have NYHA Functional class IV heart failure, or a systemic illness likely to limit survival to <1 year\nHave had recent ST elevation myocardial infarction or non-ST elevation MI (< 30 days); note that biomarker elevation alone after ventricular arrhythmias does not denote MI.\nAre pregnant.\n" ], "offsets": [ [ 0, 1174 ] ] } ]

[ { "id": "NCT02830360_exc_T2", "type": "Condition", "text": [ "ischemia" ], "offsets": [ [ 56, 64 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T3", "type": "Qualifier", "text": [ "Active" ], "offsets": [ [ 49, 55 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T4", "type": "Condition", "text": [ "acute thrombus" ], "offsets": [ [ 66, 80 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T5", "type": "Procedure", "text": [ "coronary angiography" ], "offsets": [ [ 94, 114 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T6", "type": "Condition", "text": [ "ST segment changes" ], "offsets": [ [ 127, 145 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T7", "type": "Procedure", "text": [ "ECG" ], "offsets": [ [ 162, 165 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T8", "type": "Condition", "text": [ "VT" ], "offsets": [ [ 198, 200 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T9", "type": "Qualifier", "text": [ "reversible" ], "offsets": [ [ 178, 188 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T10", "type": "Condition", "text": [ "drug-induced arrhythmia" ], "offsets": [ [ 207, 230 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T11", "type": "Condition", "text": [ "acute coronary syndrome" ], "offsets": [ [ 244, 267 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T12", "type": "Temporal", "text": [ "within 30 days," ], "offsets": [ [ 268, 283 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T13", "type": "Procedure", "text": [ "coronary revascularization" ], "offsets": [ [ 284, 310 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T14", "type": "Temporal", "text": [ "<90 days" ], "offsets": [ [ 312, 320 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T15", "type": "Procedure", "text": [ "bypass surgery" ], "offsets": [ [ 321, 335 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T16", "type": "Temporal", "text": [ "<30 days" ], "offsets": [ [ 337, 345 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T17", "type": "Procedure", "text": [ "percutaneous coronary intervention" ], "offsets": [ [ 346, 380 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T18", "type": "Condition", "text": [ "angina" ], "offsets": [ [ 415, 421 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T19", "type": "Measurement", "text": [ "CCS functional class" ], "offsets": [ [ 391, 411 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T20", "type": "Value", "text": [ "IV" ], "offsets": [ [ 412, 414 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T22", "type": "Scope", "text": [ "<90 days bypass surgery, <30 days percutaneous coronary intervention" ], "offsets": [ [ 312, 380 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T23", "type": "Scope", "text": [ "acute thrombus diagnosed by coronary angiography, or dynamic ST segment changes demonstrated on ECG) or another reversible cause of VT (e.g. drug-induced arrhythmia), had recent acute coronary syndrome within 30 days, coronary revascularization (<90 days bypass surgery, <30 days percutaneous coronary intervention" ], "offsets": [ [ 66, 380 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T24", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 641, 648 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T25", "type": "Condition", "text": [ "intolerance" ], "offsets": [ [ 650, 661 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T26", "type": "Condition", "text": [ "contraindication" ], "offsets": [ [ 665, 681 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T27", "type": "Scope", "text": [ "allergy, intolerance or contraindication" ], "offsets": [ [ 641, 681 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T28", "type": "Drug", "text": [ "antiarrhythmic drug" ], "offsets": [ [ 582, 601 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T29", "type": "Condition", "text": [ "left ventricular thrombus" ], "offsets": [ [ 711, 736 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T30", "type": "Device", "text": [ "hanical aortic an", "ves\nHa" ], "offsets": [ [ 743, 760 ], [ 772, 778 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T31", "type": "Device", "text": [ "hanical ao", "ral valves\nHa" ], "offsets": [ [ 743, 753 ], [ 765, 778 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T32", "type": "Procedure", "text": [ "catheter ablation procedure" ], "offsets": [ [ 793, 820 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T33", "type": "Condition", "text": [ "VT" ], "offsets": [ [ 825, 827 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T34", "type": "Condition", "text": [ "renal failure" ], "offsets": [ [ 835, 848 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T35", "type": "Measurement", "text": [ "Creatinine clearance" ], "offsets": [ [ 850, 870 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T36", "type": "Value", "text": [ "<15 mL/min" ], "offsets": [ [ 871, 881 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T37", "type": "Measurement", "text": [ "NYHA Functional class" ], "offsets": [ [ 889, 910 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T38", "type": "Value", "text": [ "IV" ], "offsets": [ [ 911, 913 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T39", "type": "Condition", "text": [ "heart failure" ], "offsets": [ [ 914, 927 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T40", "type": "Condition", "text": [ "systemic illness" ], "offsets": [ [ 934, 950 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T41", "type": "Observation", "text": [ "survival" ], "offsets": [ [ 967, 975 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T42", "type": "Value", "text": [ "<1 year" ], "offsets": [ [ 979, 986 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T43", "type": "Condition", "text": [ "ST elevation myocardial infarction" ], "offsets": [ [ 1003, 1037 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T44", "type": "Condition", "text": [ "non-ST elevation MI" ], "offsets": [ [ 1041, 1060 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T45", "type": "Temporal", "text": [ "< 30 days" ], "offsets": [ [ 1062, 1071 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T47", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 1164, 1172 ] ], "normalized": [] }, { "id": "NCT02830360_exc_T48", "type": "Scope", "text": [ "ST elevation myocardial infarction or non-ST elevation MI" ], "offsets": [ [ 1003, 1060 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02830360_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02830360_exc_T2", "arg2_id": "NCT02830360_exc_T3", "normalized": [] }, { "id": "NCT02830360_exc_R2", "type": "AND", "arg1_id": "NCT02830360_exc_T5", "arg2_id": "NCT02830360_exc_T4", "normalized": [] }, { "id": "NCT02830360_exc_R3", "type": "AND", "arg1_id": "NCT02830360_exc_T7", "arg2_id": "NCT02830360_exc_T6", "normalized": [] }, { "id": "NCT02830360_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT02830360_exc_T8", "arg2_id": "NCT02830360_exc_T9", "normalized": [] }, { "id": "NCT02830360_exc_R5", "type": "Subsumes", "arg1_id": "NCT02830360_exc_T8", "arg2_id": "NCT02830360_exc_T10", "normalized": [] }, { "id": "NCT02830360_exc_R6", "type": "Has_temporal", "arg1_id": "NCT02830360_exc_T11", "arg2_id": "NCT02830360_exc_T12", "normalized": [] }, { "id": "NCT02830360_exc_R7", "type": "Has_temporal", "arg1_id": "NCT02830360_exc_T15", "arg2_id": "NCT02830360_exc_T14", "normalized": [] }, { "id": "NCT02830360_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02830360_exc_T17", "arg2_id": "NCT02830360_exc_T16", "normalized": [] }, { "id": "NCT02830360_exc_R9", "type": "Subsumes", "arg1_id": "NCT02830360_exc_T13", "arg2_id": "NCT02830360_exc_T22", "normalized": [] }, { "id": "NCT02830360_exc_R10", "type": "Has_value", "arg1_id": "NCT02830360_exc_T19", "arg2_id": "NCT02830360_exc_T20", "normalized": [] }, { "id": "NCT02830360_exc_R11", "type": "AND", "arg1_id": "NCT02830360_exc_T18", "arg2_id": "NCT02830360_exc_T19", "normalized": [] }, { "id": "NCT02830360_exc_R12", "type": "Subsumes", "arg1_id": "NCT02830360_exc_T2", "arg2_id": "NCT02830360_exc_T23", "normalized": [] }, { "id": "NCT02830360_exc_R13", "type": "AND", "arg1_id": "NCT02830360_exc_T27", "arg2_id": "NCT02830360_exc_T28", "normalized": [] }, { "id": "NCT02830360_exc_R14", "type": "AND", "arg1_id": "NCT02830360_exc_T32", "arg2_id": "NCT02830360_exc_T33", "normalized": [] }, { "id": "NCT02830360_exc_R15", "type": "AND", "arg1_id": "NCT02830360_exc_T34", "arg2_id": "NCT02830360_exc_T35", "normalized": [] }, { "id": "NCT02830360_exc_R16", "type": "Has_value", "arg1_id": "NCT02830360_exc_T35", "arg2_id": "NCT02830360_exc_T36", "normalized": [] }, { "id": "NCT02830360_exc_R17", "type": "AND", "arg1_id": "NCT02830360_exc_T39", "arg2_id": "NCT02830360_exc_T37", "normalized": [] }, { "id": "NCT02830360_exc_R18", "type": "Has_value", "arg1_id": "NCT02830360_exc_T37", "arg2_id": "NCT02830360_exc_T38", "normalized": [] }, { "id": "NCT02830360_exc_R20", "type": "Has_value", "arg1_id": "NCT02830360_exc_T41", "arg2_id": "NCT02830360_exc_T42", "normalized": [] }, { "id": "NCT02830360_exc_R21", "type": "Has_temporal", "arg1_id": "NCT02830360_exc_T48", "arg2_id": "NCT02830360_exc_T45", "normalized": [] } ]

[ { "id": "NCT02830360_inc_text", "type": "inclusion", "text": [ "Prior Myocardial Infarction and\nSustained monomorphic VT documented on 12-lead ECG or rhythm strip terminated by pharmacologic means or DC cardioversion\n=3 episodes of VT treated with antitachycardia pacing (ATP), at least one of which was symptomatic\n= 5 episodes of VT treated with antitachycardia pacing (ATP) regardless of symptoms\n=1 appropriate ICD shocks,\n=3 VT episodes within 24 hours\n" ], "offsets": [ [ 0, 394 ] ] } ]

[ { "id": "NCT02830360_inc_T1", "type": "Condition", "text": [ "Myocardial Infarction" ], "offsets": [ [ 6, 27 ] ], "normalized": [] }, { "id": "NCT02830360_inc_T2", "type": "Condition", "text": [ "monomorphic VT" ], "offsets": [ [ 42, 56 ] ], "normalized": [] }, { "id": "NCT02830360_inc_T3", "type": "Qualifier", "text": [ "Sustained" ], "offsets": [ [ 32, 41 ] ], "normalized": [] }, { "id": "NCT02830360_inc_T4", "type": "Procedure", "text": [ "12-lead ECG" ], "offsets": [ [ 71, 82 ] ], "normalized": [] }, { "id": "NCT02830360_inc_T5", "type": "Procedure", "text": [ "rhythm strip" ], "offsets": [ [ 86, 98 ] ], "normalized": [] }, { "id": "NCT02830360_inc_T6", "type": "Procedure", "text": [ "pharmacologic means" ], "offsets": [ [ 113, 132 ] ], "normalized": [] }, { "id": "NCT02830360_inc_T7", "type": "Procedure", "text": [ "DC cardioversion" ], "offsets": [ [ 136, 152 ] ], "normalized": [] }, { "id": "NCT02830360_inc_T8", "type": "Scope", "text": [ "12-lead ECG or rhythm strip" ], "offsets": [ [ 71, 98 ] ], "normalized": [] }, { "id": "NCT02830360_inc_T9", "type": "Scope", "text": [ "pharmacologic means or DC cardioversion" ], "offsets": [ [ 113, 152 ] ], "normalized": [] }, { "id": "NCT02830360_inc_T10", "type": "Multiplier", "text": [ "3 episodes" ], "offsets": [ [ 154, 164 ] ], "normalized": [] }, { "id": "NCT02830360_inc_T11", "type": "Condition", "text": [ "VT" ], "offsets": [ [ 168, 170 ] ], "normalized": [] }, { "id": "NCT02830360_inc_T12", "type": "Procedure", "text": [ "antitachycardia pacing" ], "offsets": [ [ 184, 206 ] ], "normalized": [] }, { "id": "NCT02830360_inc_T13", "type": "Procedure", "text": [ "ATP" ], "offsets": [ [ 208, 211 ] ], "normalized": [] }, { "id": "NCT02830360_inc_T14", "type": "Multiplier", "text": [ "5 episodes" ], "offsets": [ [ 254, 264 ] ], "normalized": [] }, { "id": "NCT02830360_inc_T15", "type": "Condition", "text": [ "VT" ], "offsets": [ [ 268, 270 ] ], "normalized": [] }, { "id": "NCT02830360_inc_T16", "type": "Procedure", "text": [ "antitachycardia pacing" ], "offsets": [ [ 284, 306 ] ], "normalized": [] }, { "id": "NCT02830360_inc_T17", "type": "Procedure", "text": [ "ATP" ], "offsets": [ [ 308, 311 ] ], "normalized": [] }, { "id": "NCT02830360_inc_T18", "type": "Multiplier", "text": [ "at least one" ], "offsets": [ [ 214, 226 ] ], "normalized": [] }, { "id": "NCT02830360_inc_T19", "type": "Qualifier", "text": [ "symptomatic" ], "offsets": [ [ 240, 251 ] ], "normalized": [] }, { "id": "NCT02830360_inc_T20", "type": "Multiplier", "text": [ "=1" ], "offsets": [ [ 336, 338 ] ], "normalized": [] }, { "id": "NCT02830360_inc_T21", "type": "Procedure", "text": [ "ICD shocks" ], "offsets": [ [ 351, 361 ] ], "normalized": [] }, { "id": "NCT02830360_inc_T22", "type": "Multiplier", "text": [ "e", "des with" ], "offsets": [ [ 369, 370 ], [ 374, 382 ] ], "normalized": [] }, { "id": "NCT02830360_inc_T23", "type": "Condition", "text": [ "VT" ], "offsets": [ [ 366, 368 ] ], "normalized": [] }, { "id": "NCT02830360_inc_T24", "type": "Temporal", "text": [ "within 24 hours" ], "offsets": [ [ 378, 393 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02830360_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT02830360_inc_T2", "arg2_id": "NCT02830360_inc_T3", "normalized": [] }, { "id": "NCT02830360_inc_R2", "type": "AND", "arg1_id": "NCT02830360_inc_T8", "arg2_id": "NCT02830360_inc_T2", "normalized": [] }, { "id": "NCT02830360_inc_R3", "type": "AND", "arg1_id": "NCT02830360_inc_T9", "arg2_id": "NCT02830360_inc_T2", "normalized": [] }, { "id": "NCT02830360_inc_R4", "type": "Subsumes", "arg1_id": "NCT02830360_inc_T12", "arg2_id": "NCT02830360_inc_T13", "normalized": [] }, { "id": "NCT02830360_inc_R5", "type": "Has_multiplier", "arg1_id": "NCT02830360_inc_T11", "arg2_id": "NCT02830360_inc_T10", "normalized": [] }, { "id": "NCT02830360_inc_R6", "type": "AND", "arg1_id": "NCT02830360_inc_T11", "arg2_id": "NCT02830360_inc_T12", "normalized": [] }, { "id": "NCT02830360_inc_R7", "type": "Subsumes", "arg1_id": "NCT02830360_inc_T16", "arg2_id": "NCT02830360_inc_T17", "normalized": [] }, { "id": "NCT02830360_inc_R8", "type": "Has_multiplier", "arg1_id": "NCT02830360_inc_T15", "arg2_id": "NCT02830360_inc_T14", "normalized": [] }, { "id": "NCT02830360_inc_R9", "type": "AND", "arg1_id": "NCT02830360_inc_T15", "arg2_id": "NCT02830360_inc_T16", "normalized": [] }, { "id": "NCT02830360_inc_R10", "type": "Has_multiplier", "arg1_id": "NCT02830360_inc_T19", "arg2_id": "NCT02830360_inc_T18", "normalized": [] }, { "id": "NCT02830360_inc_R11", "type": "Has_qualifier", "arg1_id": "NCT02830360_inc_T11", "arg2_id": "NCT02830360_inc_T19", "normalized": [] }, { "id": "NCT02830360_inc_R12", "type": "Has_multiplier", "arg1_id": "NCT02830360_inc_T21", "arg2_id": "NCT02830360_inc_T20", "normalized": [] }, { "id": "NCT02830360_inc_R13", "type": "Has_multiplier", "arg1_id": "NCT02830360_inc_T23", "arg2_id": "NCT02830360_inc_T22", "normalized": [] }, { "id": "NCT02830360_inc_R14", "type": "Has_temporal", "arg1_id": "NCT02830360_inc_T23", "arg2_id": "NCT02830360_inc_T24", "normalized": [] } ]

[ { "id": "NCT02831166_exc_text", "type": "exclusion", "text": [ "Less than 18 years of age;\nPregnancy;\nChronic use of vitamin K antagonists or direct thrombin inhibitors, or oral Xa-factor antagonists;\nHypersensitivity to antiplatelet and/or anticoagulant drugs;\nActive bleeding or high bleeding risk (severe liver failure, active peptic ulcer, creatinine clearance < 30 mL/min, platelets count < 100.000 mm3);\nUncontrolled systemic hypertension;\nCardiogenic shock;\nPrevious myocardial revascularization surgery with = 1 internal mammary or radial artery graft;\nDocumented chronic peripheral arterial disease preventing the use of the femoral technique;\nSevere concomitant disease with life expectancy below 12 months;\nParticipation in drug or devices investigative clinical trials in the last 30 days;\nMedical, geographic or social conditions impairing the participation in the study or inability to understand and sign the informed consent term.\n" ], "offsets": [ [ 0, 883 ] ] } ]

[ { "id": "NCT02831166_exc_T1", "type": "Value", "text": [ "Less than 18 years" ], "offsets": [ [ 0, 18 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T2", "type": "Person", "text": [ "age" ], "offsets": [ [ 22, 25 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T3", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 27, 36 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T4", "type": "Drug", "text": [ "vitamin K antagonists" ], "offsets": [ [ 53, 74 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T5", "type": "Multiplier", "text": [ "Chronic" ], "offsets": [ [ 38, 45 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T6", "type": "Drug", "text": [ "direct thrombin inhibitors" ], "offsets": [ [ 78, 104 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T7", "type": "Drug", "text": [ "oral Xa-factor antagonists" ], "offsets": [ [ 109, 135 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T8", "type": "Scope", "text": [ "vitamin K antagonists or direct thrombin inhibitors, or oral Xa-factor antagonists" ], "offsets": [ [ 53, 135 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T9", "type": "Condition", "text": [ "Hypersensitivity" ], "offsets": [ [ 137, 153 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T10", "type": "Drug", "text": [ "iplatelet an", "gs;\nA" ], "offsets": [ [ 160, 172 ], [ 194, 199 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T11", "type": "Drug", "text": [ "anticoagulant drugs" ], "offsets": [ [ 177, 196 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T12", "type": "Scope", "text": [ "antiplatelet and/or anticoagulant drugs" ], "offsets": [ [ 157, 196 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T13", "type": "Condition", "text": [ "high bleeding risk" ], "offsets": [ [ 217, 235 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T14", "type": "Condition", "text": [ "bleeding" ], "offsets": [ [ 205, 213 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T15", "type": "Qualifier", "text": [ "Active" ], "offsets": [ [ 198, 204 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T16", "type": "Condition", "text": [ "liver failure" ], "offsets": [ [ 244, 257 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T17", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 237, 243 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T18", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 259, 265 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T19", "type": "Condition", "text": [ "peptic ulcer" ], "offsets": [ [ 266, 278 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T20", "type": "Measurement", "text": [ "creatinine clearance" ], "offsets": [ [ 280, 300 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T21", "type": "Value", "text": [ "< 30 mL/min" ], "offsets": [ [ 301, 312 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T22", "type": "Measurement", "text": [ "platelets count" ], "offsets": [ [ 314, 329 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T23", "type": "Value", "text": [ "< 100.000 mm3" ], "offsets": [ [ 330, 343 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T24", "type": "Qualifier", "text": [ "Uncontrolled" ], "offsets": [ [ 346, 358 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T25", "type": "Condition", "text": [ "systemic hypertension" ], "offsets": [ [ 359, 380 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T26", "type": "Condition", "text": [ "Cardiogenic shock" ], "offsets": [ [ 382, 399 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T27", "type": "Procedure", "text": [ "myocardial revascularization surgery" ], "offsets": [ [ 410, 446 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T28", "type": "Temporal", "text": [ "Previous" ], "offsets": [ [ 401, 409 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T29", "type": "Device", "text": [ "l mammary or rad", "Docum" ], "offsets": [ [ 463, 479 ], [ 497, 502 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T30", "type": "Device", "text": [ "radial artery graft" ], "offsets": [ [ 476, 495 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T31", "type": "Multiplier", "text": [ "= 1" ], "offsets": [ [ 452, 455 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T32", "type": "Scope", "text": [ "internal mammary or radial artery graft" ], "offsets": [ [ 456, 495 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T33", "type": "Qualifier", "text": [ "chronic" ], "offsets": [ [ 508, 515 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T34", "type": "Condition", "text": [ "peripheral arterial disease" ], "offsets": [ [ 516, 543 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T35", "type": "Procedure", "text": [ "femoral technique" ], "offsets": [ [ 570, 587 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T36", "type": "Negation", "text": [ "preventing" ], "offsets": [ [ 544, 554 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T37", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 589, 595 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T38", "type": "Temporal", "text": [ "concomitant" ], "offsets": [ [ 596, 607 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T39", "type": "Condition", "text": [ "disease" ], "offsets": [ [ 608, 615 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T40", "type": "Observation", "text": [ "life expectancy" ], "offsets": [ [ 621, 636 ] ], "normalized": [] }, { "id": "NCT02831166_exc_T41", "type": "Value", "text": [ "below 12 months" ], "offsets": [ [ 637, 652 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02831166_exc_R1", "type": "Has_value", "arg1_id": "NCT02831166_exc_T2", "arg2_id": "NCT02831166_exc_T1", "normalized": [] }, { "id": "NCT02831166_exc_R2", "type": "Has_multiplier", "arg1_id": "NCT02831166_exc_T8", "arg2_id": "NCT02831166_exc_T5", "normalized": [] }, { "id": "NCT02831166_exc_R3", "type": "Has_scope", "arg1_id": "NCT02831166_exc_T9", "arg2_id": "NCT02831166_exc_T12", "normalized": [] }, { "id": "NCT02831166_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT02831166_exc_T14", "arg2_id": "NCT02831166_exc_T15", "normalized": [] }, { "id": "NCT02831166_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02831166_exc_T16", "arg2_id": "NCT02831166_exc_T17", "normalized": [] }, { "id": "NCT02831166_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02831166_exc_T19", "arg2_id": "NCT02831166_exc_T18", "normalized": [] }, { "id": "NCT02831166_exc_R7", "type": "Has_value", "arg1_id": "NCT02831166_exc_T20", "arg2_id": "NCT02831166_exc_T21", "normalized": [] }, { "id": "NCT02831166_exc_R8", "type": "Has_value", "arg1_id": "NCT02831166_exc_T22", "arg2_id": "NCT02831166_exc_T23", "normalized": [] }, { "id": "NCT02831166_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT02831166_exc_T25", "arg2_id": "NCT02831166_exc_T24", "normalized": [] }, { "id": "NCT02831166_exc_R10", "type": "Has_temporal", "arg1_id": "NCT02831166_exc_T27", "arg2_id": "NCT02831166_exc_T28", "normalized": [] }, { "id": "NCT02831166_exc_R11", "type": "Has_multiplier", "arg1_id": "NCT02831166_exc_T32", "arg2_id": "NCT02831166_exc_T31", "normalized": [] }, { "id": "NCT02831166_exc_R12", "type": "Has_scope", "arg1_id": "NCT02831166_exc_T27", "arg2_id": "NCT02831166_exc_T32", "normalized": [] }, { "id": "NCT02831166_exc_R13", "type": "Has_negation", "arg1_id": "NCT02831166_exc_T35", "arg2_id": "NCT02831166_exc_T36", "normalized": [] }, { "id": "NCT02831166_exc_R14", "type": "AND", "arg1_id": "NCT02831166_exc_T34", "arg2_id": "NCT02831166_exc_T35", "normalized": [] }, { "id": "NCT02831166_exc_R15", "type": "Has_qualifier", "arg1_id": "NCT02831166_exc_T34", "arg2_id": "NCT02831166_exc_T33", "normalized": [] }, { "id": "NCT02831166_exc_R16", "type": "Has_value", "arg1_id": "NCT02831166_exc_T40", "arg2_id": "NCT02831166_exc_T41", "normalized": [] }, { "id": "NCT02831166_exc_R17", "type": "Has_temporal", "arg1_id": "NCT02831166_exc_T39", "arg2_id": "NCT02831166_exc_T38", "normalized": [] }, { "id": "NCT02831166_exc_R18", "type": "Has_qualifier", "arg1_id": "NCT02831166_exc_T39", "arg2_id": "NCT02831166_exc_T37", "normalized": [] } ]

[ { "id": "NCT02831166_inc_text", "type": "inclusion", "text": [ "ST-segment elevation acute myocardial infarction patients during the first 12 hours of sympton onset;\nIntention to perform primary percutaneous coronary intervention;\nSigned informed consent;\nPatient eligible for transradial and transfemoral primary percutaneous coronary intervention, being pre-requisites: (a) familiarity of the operator with the radial and femoral techniques using vascular closure devices, (b) agreement of the operator to use the access route determined by the randomization process.\n" ], "offsets": [ [ 0, 506 ] ] } ]

[ { "id": "NCT02831166_inc_T1", "type": "Qualifier", "text": [ "ST-segment elevation" ], "offsets": [ [ 0, 20 ] ], "normalized": [] }, { "id": "NCT02831166_inc_T2", "type": "Condition", "text": [ "acute myocardial infarction" ], "offsets": [ [ 21, 48 ] ], "normalized": [] }, { "id": "NCT02831166_inc_T3", "type": "Temporal", "text": [ "during the first 12 hours of sympton onset" ], "offsets": [ [ 58, 100 ] ], "normalized": [] }, { "id": "NCT02831166_inc_T4", "type": "Condition", "text": [ "percutaneous coronary intervention" ], "offsets": [ [ 131, 165 ] ], "normalized": [] }, { "id": "NCT02831166_inc_T5", "type": "Mood", "text": [ "Intention to perform" ], "offsets": [ [ 102, 122 ] ], "normalized": [] }, { "id": "NCT02831166_inc_T6", "type": "Qualifier", "text": [ "primary" ], "offsets": [ [ 123, 130 ] ], "normalized": [] }, { "id": "NCT02831166_inc_T8", "type": "Qualifier", "text": [ "transradial" ], "offsets": [ [ 213, 224 ] ], "normalized": [] }, { "id": "NCT02831166_inc_T9", "type": "Qualifier", "text": [ "transfemoral" ], "offsets": [ [ 229, 241 ] ], "normalized": [] }, { "id": "NCT02831166_inc_T10", "type": "Qualifier", "text": [ "primary" ], "offsets": [ [ 242, 249 ] ], "normalized": [] }, { "id": "NCT02831166_inc_T11", "type": "Procedure", "text": [ "percutaneous coronary intervention" ], "offsets": [ [ 250, 284 ] ], "normalized": [] }, { "id": "NCT02831166_inc_T12", "type": "Scope", "text": [ "transradial and transfemoral" ], "offsets": [ [ 213, 241 ] ], "normalized": [] }, { "id": "NCT02831166_inc_T13", "type": "Mood", "text": [ "eligible for" ], "offsets": [ [ 200, 212 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT02831166_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT02831166_inc_T2", "arg2_id": "NCT02831166_inc_T1", "normalized": [] }, { "id": "NCT02831166_inc_R2", "type": "Has_temporal", "arg1_id": "NCT02831166_inc_T2", "arg2_id": "NCT02831166_inc_T3", "normalized": [] }, { "id": "NCT02831166_inc_R3", "type": "Has_mood", "arg1_id": "NCT02831166_inc_T4", "arg2_id": "NCT02831166_inc_T5", "normalized": [] }, { "id": "NCT02831166_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT02831166_inc_T4", "arg2_id": "NCT02831166_inc_T6", "normalized": [] }, { "id": "NCT02831166_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT02831166_inc_T11", "arg2_id": "NCT02831166_inc_T10", "normalized": [] }, { "id": "NCT02831166_inc_R6", "type": "Has_scope", "arg1_id": "NCT02831166_inc_T11", "arg2_id": "NCT02831166_inc_T12", "normalized": [] }, { "id": "NCT02831166_inc_R7", "type": "Has_mood", "arg1_id": "NCT02831166_inc_T11", "arg2_id": "NCT02831166_inc_T13", "normalized": [] } ]

[ { "id": "NCT02833116_exc_text", "type": "exclusion", "text": [ "Patients with high intracranial pressure.\nPatients with Multiple Sclerosis.\nPatients with Guillain-Barré syndrome radiculopathy of vascular origin.\nPatients with previous lumbar surgery.\nPatients pregnant or lactating.\nPatients with allergy or intolerance to any of the drugs used.\nPatients with severe cognitive impairment.\nPatients with intrathecal injectio radiculalgia.\nPatients with poorly controlled major psychiatric pathology.\nPatients with type I diabetes or poorly controlled type II diabetes (Hb1Ac>8.5).\nPatients with glaucoma.\nPatients with caudal equine syndrome.\nPatients with pre-treatment with steroid injections/or local anesthetics.\nPatients with central canal stenosis.\npatients with chronic treatment with oral corticosteroids without stabilized pattern.\n" ], "offsets": [ [ 0, 776 ] ] } ]

[ { "id": "NCT02833116_exc_T1", "type": "Measurement", "text": [ "intracranial pressure" ], "offsets": [ [ 19, 40 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T2", "type": "Value", "text": [ "high" ], "offsets": [ [ 14, 18 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T3", "type": "Condition", "text": [ "Multiple Sclerosis" ], "offsets": [ [ 56, 74 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T4", "type": "Condition", "text": [ "Guillain-Barré syndrome radiculopathy" ], "offsets": [ [ 90, 127 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T5", "type": "Qualifier", "text": [ "vascular" ], "offsets": [ [ 131, 139 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T6", "type": "Procedure", "text": [ "lumbar surgery." ], "offsets": [ [ 171, 186 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T8", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 233, 240 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T9", "type": "Condition", "text": [ "intolerance" ], "offsets": [ [ 244, 255 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T10", "type": "Drug", "text": [ "drugs" ], "offsets": [ [ 270, 275 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T11", "type": "Scope", "text": [ "allergy or intolerance" ], "offsets": [ [ 233, 255 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T12", "type": "Condition", "text": [ "cognitive impairment" ], "offsets": [ [ 303, 323 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T13", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 296, 302 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T14", "type": "Procedure", "text": [ "intrathecal injectio radiculalgia" ], "offsets": [ [ 339, 372 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T15", "type": "Condition", "text": [ "psychiatric pathology" ], "offsets": [ [ 412, 433 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T16", "type": "Qualifier", "text": [ "major" ], "offsets": [ [ 406, 411 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T17", "type": "Qualifier", "text": [ "poorly controlled" ], "offsets": [ [ 388, 405 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T18", "type": "Condition", "text": [ "type I diabetes" ], "offsets": [ [ 449, 464 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T19", "type": "Condition", "text": [ "type II diabetes" ], "offsets": [ [ 486, 502 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T20", "type": "Qualifier", "text": [ "poorly controlled" ], "offsets": [ [ 468, 485 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T21", "type": "Measurement", "text": [ "Hb1Ac" ], "offsets": [ [ 504, 509 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T22", "type": "Value", "text": [ ">8.5" ], "offsets": [ [ 509, 513 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T23", "type": "Condition", "text": [ "glaucoma" ], "offsets": [ [ 530, 538 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T24", "type": "Condition", "text": [ "caudal equine syndrome" ], "offsets": [ [ 554, 576 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T25", "type": "Procedure", "text": [ "steroid injections" ], "offsets": [ [ 611, 629 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T26", "type": "Procedure", "text": [ "local anesthetics" ], "offsets": [ [ 633, 650 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T27", "type": "Condition", "text": [ "central canal stenosis" ], "offsets": [ [ 666, 688 ] ], "normalized": [] }, { "id": "NCT02833116_exc_T28", "type": "Drug", "text": [ "oral corticosteroids" ], "offsets": [ [ 727, 747 ] ], "normalized": [] } ]

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[ { "id": "NCT02833116_exc_R1", "type": "Has_value", "arg1_id": "NCT02833116_exc_T1", "arg2_id": "NCT02833116_exc_T2", "normalized": [] }, { "id": "NCT02833116_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02833116_exc_T4", "arg2_id": "NCT02833116_exc_T5", "normalized": [] }, { "id": "NCT02833116_exc_R3", "type": "AND", "arg1_id": "NCT02833116_exc_T11", "arg2_id": "NCT02833116_exc_T10", "normalized": [] }, { "id": "NCT02833116_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT02833116_exc_T12", "arg2_id": "NCT02833116_exc_T13", "normalized": [] }, { "id": "NCT02833116_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02833116_exc_T15", "arg2_id": "NCT02833116_exc_T16", "normalized": [] }, { "id": "NCT02833116_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02833116_exc_T15", "arg2_id": "NCT02833116_exc_T17", "normalized": [] }, { "id": "NCT02833116_exc_R7", "type": "Has_value", "arg1_id": "NCT02833116_exc_T21", "arg2_id": "NCT02833116_exc_T22", "normalized": [] }, { "id": "NCT02833116_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT02833116_exc_T19", "arg2_id": "NCT02833116_exc_T20", "normalized": [] }, { "id": "NCT02833116_exc_R9", "type": "AND", "arg1_id": "NCT02833116_exc_T19", "arg2_id": "NCT02833116_exc_T21", "normalized": [] } ]

[ { "id": "NCT02833116_inc_text", "type": "inclusion", "text": [ "Unilateral leg pain secondary to lateral stenosis, disc protrusion or herniated disc.\nAge between 18 and 80 years.\nModerate to severe pain (NVS>4).\nRight proficient oral and written language.\n" ], "offsets": [ [ 0, 192 ] ] } ]

[ { "id": "NCT02833116_inc_T1", "type": "Condition", "text": [ "Unilateral leg pain" ], "offsets": [ [ 0, 19 ] ], "normalized": [] }, { "id": "NCT02833116_inc_T2", "type": "Condition", "text": [ "lateral stenosis" ], "offsets": [ [ 33, 49 ] ], "normalized": [] }, { "id": "NCT02833116_inc_T3", "type": "Condition", "text": [ "disc protrusion" ], "offsets": [ [ 51, 66 ] ], "normalized": [] }, { "id": "NCT02833116_inc_T4", "type": "Condition", "text": [ "herniated disc" ], "offsets": [ [ 70, 84 ] ], "normalized": [] }, { "id": "NCT02833116_inc_T5", "type": "Scope", "text": [ "lateral stenosis, disc protrusion or herniated disc" ], "offsets": [ [ 33, 84 ] ], "normalized": [] }, { "id": "NCT02833116_inc_T6", "type": "Person", "text": [ "Age" ], "offsets": [ [ 86, 89 ] ], "normalized": [] }, { "id": "NCT02833116_inc_T7", "type": "Value", "text": [ "between 18 and 80 years" ], "offsets": [ [ 90, 113 ] ], "normalized": [] }, { "id": "NCT02833116_inc_T8", "type": "Condition", "text": [ "pain" ], "offsets": [ [ 134, 138 ] ], "normalized": [] }, { "id": "NCT02833116_inc_T9", "type": "Measurement", "text": [ "NVS" ], "offsets": [ [ 140, 143 ] ], "normalized": [] }, { "id": "NCT02833116_inc_T10", "type": "Value", "text": [ ">4)" ], "offsets": [ [ 143, 146 ] ], "normalized": [] }, { "id": "NCT02833116_inc_T11", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 127, 133 ] ], "normalized": [] }, { "id": "NCT02833116_inc_T12", "type": "Qualifier", "text": [ "Moderate" ], "offsets": [ [ 115, 123 ] ], "normalized": [] }, { "id": "NCT02833116_inc_T13", "type": "Scope", "text": [ "Moderate to severe" ], "offsets": [ [ 115, 133 ] ], "normalized": [] } ]

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[ { "id": "NCT02833116_inc_R1", "type": "AND", "arg1_id": "NCT02833116_inc_T5", "arg2_id": "NCT02833116_inc_T1", "normalized": [] }, { "id": "NCT02833116_inc_R2", "type": "Has_value", "arg1_id": "NCT02833116_inc_T6", "arg2_id": "NCT02833116_inc_T7", "normalized": [] }, { "id": "NCT02833116_inc_R3", "type": "Has_value", "arg1_id": "NCT02833116_inc_T9", "arg2_id": "NCT02833116_inc_T10", "normalized": [] }, { "id": "NCT02833116_inc_R4", "type": "AND", "arg1_id": "NCT02833116_inc_T8", "arg2_id": "NCT02833116_inc_T9", "normalized": [] }, { "id": "NCT02833116_inc_R5", "type": "Has_scope", "arg1_id": "NCT02833116_inc_T8", "arg2_id": "NCT02833116_inc_T13", "normalized": [] } ]

[ { "id": "NCT02833623_exc_text", "type": "exclusion", "text": [ "advanced chronic disease that would not allow the patient to complete the treatment or follow-up or attend visits\nallergy to any of the drugs used in this study\nprevious Helicobacter Pylori eradication treatment\npregnancy or breastfeeding (female participants with childbearing potential were required to use medically accepted contraception for the duration of the study)\ntaking antibiotics or PPIs or bismuth salts within four weeks\nprevious gastrointestinal surgery\n" ], "offsets": [ [ 0, 469 ] ] } ]

[ { "id": "NCT02833623_exc_T3", "type": "Procedure", "text": [ "Helicobacter Pylori eradication treatment" ], "offsets": [ [ 170, 211 ] ], "normalized": [] }, { "id": "NCT02833623_exc_T5", "type": "Drug", "text": [ "antibiotics" ], "offsets": [ [ 380, 391 ] ], "normalized": [] }, { "id": "NCT02833623_exc_T6", "type": "Drug", "text": [ "PPIs" ], "offsets": [ [ 395, 399 ] ], "normalized": [] }, { "id": "NCT02833623_exc_T7", "type": "Drug", "text": [ "bismuth salts" ], "offsets": [ [ 403, 416 ] ], "normalized": [] }, { "id": "NCT02833623_exc_T8", "type": "Temporal", "text": [ "within four weeks" ], "offsets": [ [ 417, 434 ] ], "normalized": [] }, { "id": "NCT02833623_exc_T9", "type": "Scope", "text": [ "antibiotics or PPIs or bismuth salts" ], "offsets": [ [ 380, 416 ] ], "normalized": [] }, { "id": "NCT02833623_exc_T10", "type": "Procedure", "text": [ "gastrointestinal surgery" ], "offsets": [ [ 444, 468 ] ], "normalized": [] } ]

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[ { "id": "NCT02833623_exc_R1", "type": "Has_temporal", "arg1_id": "NCT02833623_exc_T9", "arg2_id": "NCT02833623_exc_T8", "normalized": [] } ]

[ { "id": "NCT02833623_inc_text", "type": "inclusion", "text": [ "outpatients aged 18-70 years\nconfirmed diagnosis of H. pylori infection by at least one of the following methods: 13C-urea breath test, histology, rapid urease test or bacterial culture\nan intention of H. pylori eradication treatment and have written inform consent\nability to read short messages on the mobile phone\n" ], "offsets": [ [ 0, 317 ] ] } ]

[ { "id": "NCT02833623_inc_T1", "type": "Visit", "text": [ "outpatients" ], "offsets": [ [ 0, 11 ] ], "normalized": [] }, { "id": "NCT02833623_inc_T2", "type": "Person", "text": [ "aged" ], "offsets": [ [ 12, 16 ] ], "normalized": [] }, { "id": "NCT02833623_inc_T3", "type": "Value", "text": [ "18-70 years" ], "offsets": [ [ 17, 28 ] ], "normalized": [] }, { "id": "NCT02833623_inc_T4", "type": "Condition", "text": [ "H. pylori infection" ], "offsets": [ [ 52, 71 ] ], "normalized": [] }, { "id": "NCT02833623_inc_T5", "type": "Measurement", "text": [ "13C-urea breath test" ], "offsets": [ [ 114, 134 ] ], "normalized": [] }, { "id": "NCT02833623_inc_T6", "type": "Measurement", "text": [ "histology" ], "offsets": [ [ 136, 145 ] ], "normalized": [] }, { "id": "NCT02833623_inc_T7", "type": "Measurement", "text": [ "rapid urease test" ], "offsets": [ [ 147, 164 ] ], "normalized": [] }, { "id": "NCT02833623_inc_T8", "type": "Measurement", "text": [ "bacterial culture" ], "offsets": [ [ 168, 185 ] ], "normalized": [] }, { "id": "NCT02833623_inc_T9", "type": "Scope", "text": [ "13C-urea breath test, histology, rapid urease test or bacterial culture" ], "offsets": [ [ 114, 185 ] ], "normalized": [] } ]

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[ { "id": "NCT02833623_inc_R1", "type": "Has_value", "arg1_id": "NCT02833623_inc_T2", "arg2_id": "NCT02833623_inc_T3", "normalized": [] }, { "id": "NCT02833623_inc_R2", "type": "AND", "arg1_id": "NCT02833623_inc_T9", "arg2_id": "NCT02833623_inc_T4", "normalized": [] } ]