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BigScience Biomedical Datasets 140

[ { "id": "NCT02584140_exc_text", "type": "exclusion", "text": [ "Pregnancy at enrollment.\nAny condition, which in the opinion of the provider, will seriously compromise the participant's ability to comply with the protocol, including adherence to PrEP medication dosing, such as active, untreated or unstable major mental illness (i.e. untreated psychotic disorder).\nUse of prohibited medications, in particular, agents known to be nephrotoxic or drugs slow in renal excretion.\nPrevious participation in an HIV vaccine trial. Participants that were documented to have received only placebo are not excluded.\nSigns or symptoms suspicious for Primary HIV Infection (PHI).\n" ], "offsets": [ [ 0, 605 ] ] } ]

[ { "id": "NCT02584140_exc_T1", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 0, 9 ] ], "normalized": [] }, { "id": "NCT02584140_exc_T2", "type": "Temporal", "text": [ "at enrollment" ], "offsets": [ [ 10, 23 ] ], "normalized": [] }, { "id": "NCT02584140_exc_T3", "type": "Reference_point", "text": [ "enrollment" ], "offsets": [ [ 13, 23 ] ], "normalized": [] }, { "id": "NCT02584140_exc_T5", "type": "Qualifier", "text": [ "nephrotoxic" ], "offsets": [ [ 367, 378 ] ], "normalized": [] }, { "id": "NCT02584140_exc_T6", "type": "Procedure", "text": [ "agents" ], "offsets": [ [ 348, 354 ] ], "normalized": [] }, { "id": "NCT02584140_exc_T7", "type": "Procedure", "text": [ "drugs" ], "offsets": [ [ 382, 387 ] ], "normalized": [] }, { "id": "NCT02584140_exc_T8", "type": "Qualifier", "text": [ "slow in renal excretion" ], "offsets": [ [ 388, 411 ] ], "normalized": [] }, { "id": "NCT02584140_exc_T10", "type": "Observation", "text": [ "HIV vaccine trial" ], "offsets": [ [ 442, 459 ] ], "normalized": [] }, { "id": "NCT02584140_exc_T11", "type": "Person", "text": [ "participation" ], "offsets": [ [ 422, 435 ] ], "normalized": [] }, { "id": "NCT02584140_exc_T12", "type": "Temporal", "text": [ "Previous" ], "offsets": [ [ 413, 421 ] ], "normalized": [] }, { "id": "NCT02584140_exc_T13", "type": "Person", "text": [ "Participants" ], "offsets": [ [ 461, 473 ] ], "normalized": [] }, { "id": "NCT02584140_exc_T14", "type": "Procedure", "text": [ "placebo" ], "offsets": [ [ 517, 524 ] ], "normalized": [] }, { "id": "NCT02584140_exc_T15", "type": "Mood", "text": [ "not" ], "offsets": [ [ 529, 532 ] ], "normalized": [] }, { "id": "NCT02584140_exc_T16", "type": "Condition", "text": [ "Primary HIV Infection" ], "offsets": [ [ 576, 597 ] ], "normalized": [] }, { "id": "NCT02584140_exc_T17", "type": "Condition", "text": [ "PHI" ], "offsets": [ [ 599, 602 ] ], "normalized": [] }, { "id": "NCT02584140_exc_T18", "type": "Condition", "text": [ "symptoms" ], "offsets": [ [ 552, 560 ] ], "normalized": [] }, { "id": "NCT02584140_exc_T19", "type": "Condition", "text": [ "Signs" ], "offsets": [ [ 543, 548 ] ], "normalized": [] }, { "id": "NCT02584140_exc_T20", "type": "Scope", "text": [ "Signs or symptoms" ], "offsets": [ [ 543, 560 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02584140_exc_R1", "type": "Has_index", "arg1_id": "NCT02584140_exc_T2", "arg2_id": "NCT02584140_exc_T3", "normalized": [] }, { "id": "NCT02584140_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02584140_exc_T6", "arg2_id": "NCT02584140_exc_T5", "normalized": [] }, { "id": "NCT02584140_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02584140_exc_T7", "arg2_id": "NCT02584140_exc_T8", "normalized": [] }, { "id": "NCT02584140_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02584140_exc_T11", "arg2_id": "NCT02584140_exc_T12", "normalized": [] }, { "id": "NCT02584140_exc_R6", "type": "Has_temporal", "arg1_id": "NCT02584140_exc_T13", "arg2_id": "NCT02584140_exc_T12", "normalized": [] }, { "id": "NCT02584140_exc_R8", "type": "AND", "arg1_id": "NCT02584140_exc_T13", "arg2_id": "NCT02584140_exc_T14", "normalized": [] }, { "id": "NCT02584140_exc_R9", "type": "Has_mood", "arg1_id": "NCT02584140_exc_T13", "arg2_id": "NCT02584140_exc_T15", "normalized": [] }, { "id": "NCT02584140_exc_R10", "type": "Subsumes", "arg1_id": "NCT02584140_exc_T16", "arg2_id": "NCT02584140_exc_T17", "normalized": [] }, { "id": "NCT02584140_exc_R11", "type": "AND", "arg1_id": "NCT02584140_exc_T20", "arg2_id": "NCT02584140_exc_T16", "normalized": [] } ]

[ { "id": "NCT02584140_inc_text", "type": "inclusion", "text": [ "Female at birth and identifies as female gender\nAge 18 years or older\nAble to understand and provide consent in English or Spanish\nHIV negative by 4th generation test (Ag/Ab test) or combination of enzymeimmunoassay (EIA) and HIV RNA\nCreatinine clearance = 60 ml/min (via Cockcroft-Gault formula)\nCondomless sex in the last 3 months with one or more male partners of unknown HIV status known to be at substantial risk of HIV infection (IDU, bisexual, sex for goods, recently incarcerated, from a country with HIV prevalence >1%, interpersonal Partner Violence);\nSTI (rectal or vaginal gonorrhea or syphilis) diagnosis during the last 6 months.\nPrevious post-exposure prophylaxis (PEP) use during the last 12 months.\nHas at least one HIV-infected sexual partner for =4 weeks.\nSex for exchange of money, goods or services\n" ], "offsets": [ [ 0, 820 ] ] } ]

[ { "id": "NCT02584140_inc_T1", "type": "Person", "text": [ "Female" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T2", "type": "Temporal", "text": [ "at birth" ], "offsets": [ [ 7, 15 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T3", "type": "Reference_point", "text": [ "birth" ], "offsets": [ [ 10, 15 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T4", "type": "Person", "text": [ "gender" ], "offsets": [ [ 41, 47 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T5", "type": "Value", "text": [ "female" ], "offsets": [ [ 34, 40 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T7", "type": "Measurement", "text": [ " n", " generation test (" ], "offsets": [ [ 134, 136 ], [ 150, 168 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T8", "type": "Value", "text": [ "negative" ], "offsets": [ [ 135, 143 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T9", "type": "Measurement", "text": [ "Ag/Ab test" ], "offsets": [ [ 168, 178 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T10", "type": "Measurement", "text": [ "enzymeimmunoassay" ], "offsets": [ [ 198, 215 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T11", "type": "Measurement", "text": [ "HIV RNA" ], "offsets": [ [ 226, 233 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T12", "type": "Measurement", "text": [ "EIA" ], "offsets": [ [ 217, 220 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T13", "type": "Scope", "text": [ "enzymeimmunoassay (EIA) and HIV RN" ], "offsets": [ [ 198, 232 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T14", "type": "Measurement", "text": [ "Creatinine clearance" ], "offsets": [ [ 234, 254 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T15", "type": "Value", "text": [ "= 60 ml/min" ], "offsets": [ [ 255, 266 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T16", "type": "Measurement", "text": [ "Cockcroft-Gault formula" ], "offsets": [ [ 272, 295 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T17", "type": "Observation", "text": [ "Condomless sex" ], "offsets": [ [ 297, 311 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T18", "type": "Temporal", "text": [ "in the last 3 months" ], "offsets": [ [ 312, 332 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T19", "type": "Multiplier", "text": [ "one or more" ], "offsets": [ [ 338, 349 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T20", "type": "Person", "text": [ "male partners" ], "offsets": [ [ 350, 363 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T21", "type": "Condition", "text": [ "unknown HIV status" ], "offsets": [ [ 367, 385 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T22", "type": "Observation", "text": [ "substantial risk of HIV infection" ], "offsets": [ [ 401, 434 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T23", "type": "Condition", "text": [ "HIV infection" ], "offsets": [ [ 421, 434 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T24", "type": "Observation", "text": [ "IDU" ], "offsets": [ [ 436, 439 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T25", "type": "Observation", "text": [ "bisexual" ], "offsets": [ [ 441, 449 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T26", "type": "Observation", "text": [ "sex for goods" ], "offsets": [ [ 451, 464 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T27", "type": "Observation", "text": [ "recently incarcerated" ], "offsets": [ [ 466, 487 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T28", "type": "Observation", "text": [ "from a country with HIV prevalence >1%" ], "offsets": [ [ 489, 527 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T29", "type": "Observation", "text": [ "interpersonal Partner Violence" ], "offsets": [ [ 529, 559 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T30", "type": "Condition", "text": [ "STI" ], "offsets": [ [ 562, 565 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T31", "type": "Condition", "text": [ "syphilis" ], "offsets": [ [ 598, 606 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T32", "type": "Condition", "text": [ "vaginal gonorrhea" ], "offsets": [ [ 577, 594 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T33", "type": "Condition", "text": [ " or v", "hea or sy" ], "offsets": [ [ 573, 578 ], [ 591, 600 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T34", "type": "Scope", "text": [ "rectal or vaginal gonorrhea or syphilis" ], "offsets": [ [ 567, 606 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T35", "type": "Temporal", "text": [ "during the last 6 months" ], "offsets": [ [ 618, 642 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T36", "type": "Procedure", "text": [ "posure prophylaxis (PEP)", "ing" ], "offsets": [ [ 660, 684 ], [ 692, 695 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T37", "type": "Procedure", "text": [ "PEP" ], "offsets": [ [ 680, 683 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T38", "type": "Temporal", "text": [ "during the last 12 months" ], "offsets": [ [ 689, 714 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T39", "type": "Multiplier", "text": [ "at least one" ], "offsets": [ [ 720, 732 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T40", "type": "Observation", "text": [ "sexual partner" ], "offsets": [ [ 746, 760 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T41", "type": "Condition", "text": [ "HIV-infected" ], "offsets": [ [ 733, 745 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T42", "type": "Value", "text": [ "=4 weeks" ], "offsets": [ [ 765, 773 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T43", "type": "Observation", "text": [ "Sex for exchange of money, goods or services" ], "offsets": [ [ 775, 819 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T44", "type": "Person", "text": [ "Age" ], "offsets": [ [ 48, 51 ] ], "normalized": [] }, { "id": "NCT02584140_inc_T45", "type": "Value", "text": [ "18 years or older" ], "offsets": [ [ 52, 69 ] ], "normalized": [] } ]

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[ { "id": "NCT02584140_inc_R1", "type": "Has_index", "arg1_id": "NCT02584140_inc_T2", "arg2_id": "NCT02584140_inc_T3", "normalized": [] }, { "id": "NCT02584140_inc_R2", "type": "Has_value", "arg1_id": "NCT02584140_inc_T4", "arg2_id": "NCT02584140_inc_T5", "normalized": [] }, { "id": "NCT02584140_inc_R3", "type": "Has_temporal", "arg1_id": "NCT02584140_inc_T1", "arg2_id": "NCT02584140_inc_T2", "normalized": [] }, { "id": "NCT02584140_inc_R4", "type": "Has_value", "arg1_id": "NCT02584140_inc_T7", "arg2_id": "NCT02584140_inc_T8", "normalized": [] }, { "id": "NCT02584140_inc_R5", "type": "Subsumes", "arg1_id": "NCT02584140_inc_T7", "arg2_id": "NCT02584140_inc_T9", "normalized": [] }, { "id": "NCT02584140_inc_R6", "type": "Subsumes", "arg1_id": "NCT02584140_inc_T10", "arg2_id": "NCT02584140_inc_T12", "normalized": [] }, { "id": "NCT02584140_inc_R7", "type": "Has_value", "arg1_id": "NCT02584140_inc_T13", "arg2_id": "NCT02584140_inc_T8", "normalized": [] }, { "id": "NCT02584140_inc_R8", "type": "Subsumes", "arg1_id": "NCT02584140_inc_T14", "arg2_id": "NCT02584140_inc_T16", "normalized": [] }, { "id": "NCT02584140_inc_R9", "type": "Has_value", "arg1_id": "NCT02584140_inc_T14", "arg2_id": "NCT02584140_inc_T15", "normalized": [] }, { "id": "NCT02584140_inc_R10", "type": "Has_temporal", "arg1_id": "NCT02584140_inc_T17", "arg2_id": "NCT02584140_inc_T18", "normalized": [] }, { "id": "NCT02584140_inc_R13", "type": "Has_multiplier", "arg1_id": "NCT02584140_inc_T20", "arg2_id": "NCT02584140_inc_T19", "normalized": [] }, { "id": "NCT02584140_inc_R14", "type": "AND", "arg1_id": "NCT02584140_inc_T20", "arg2_id": "NCT02584140_inc_T21", "normalized": [] }, { "id": "NCT02584140_inc_R15", "type": "AND", "arg1_id": "NCT02584140_inc_T17", "arg2_id": "NCT02584140_inc_T20", "normalized": [] }, { "id": "NCT02584140_inc_R16", "type": "Subsumes", "arg1_id": "NCT02584140_inc_T30", "arg2_id": "NCT02584140_inc_T34", "normalized": [] }, { "id": "NCT02584140_inc_R17", "type": "Subsumes", "arg1_id": "NCT02584140_inc_T36", "arg2_id": "NCT02584140_inc_T37", "normalized": [] }, { "id": "NCT02584140_inc_R18", "type": "AND", "arg1_id": "NCT02584140_inc_T40", "arg2_id": "NCT02584140_inc_T41", "normalized": [] }, { "id": "NCT02584140_inc_R19", "type": "Has_multiplier", "arg1_id": "NCT02584140_inc_T40", "arg2_id": "NCT02584140_inc_T39", "normalized": [] }, { "id": "NCT02584140_inc_R20", "type": "Has_value", "arg1_id": "NCT02584140_inc_T40", "arg2_id": "NCT02584140_inc_T42", "normalized": [] }, { "id": "NCT02584140_inc_R21", "type": "Has_value", "arg1_id": "NCT02584140_inc_T44", "arg2_id": "NCT02584140_inc_T45", "normalized": [] } ]

[ { "id": "NCT02589353_exc_text", "type": "exclusion", "text": [ "adults 61 years old and above\nsmokers\npregnant women\ntaking any prescription pain/ insulin medication\nhas a history of taste or smell loss or other oral disorders (e.g., burning mouth syndrome)\nhas current oral lesions, canker sores, or piercings\nhas a history of food allergy\n" ], "offsets": [ [ 0, 277 ] ] } ]

[ { "id": "NCT02589353_exc_T1", "type": "Person", "text": [ "adults" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "NCT02589353_exc_T2", "type": "Value", "text": [ "and above", "61 years" ], "offsets": [ [ 20, 29 ], [ 7, 15 ] ], "normalized": [] }, { "id": "NCT02589353_exc_T3", "type": "Person", "text": [ "old" ], "offsets": [ [ 16, 19 ] ], "normalized": [] }, { "id": "NCT02589353_exc_T4", "type": "Observation", "text": [ "smokers" ], "offsets": [ [ 30, 37 ] ], "normalized": [] }, { "id": "NCT02589353_exc_T5", "type": "Person", "text": [ "women" ], "offsets": [ [ 47, 52 ] ], "normalized": [] }, { "id": "NCT02589353_exc_T6", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 38, 46 ] ], "normalized": [] }, { "id": "NCT02589353_exc_T7", "type": "Drug", "text": [ "scription pa", "ulin medication\nha" ], "offsets": [ [ 67, 79 ], [ 86, 104 ] ], "normalized": [] }, { "id": "NCT02589353_exc_T8", "type": "Drug", "text": [ "scription pain/ i", "ication\nha" ], "offsets": [ [ 67, 84 ], [ 94, 104 ] ], "normalized": [] }, { "id": "NCT02589353_exc_T9", "type": "Observation", "text": [ "history" ], "offsets": [ [ 108, 115 ] ], "normalized": [] }, { "id": "NCT02589353_exc_T10", "type": "Condition", "text": [ "smell loss" ], "offsets": [ [ 128, 138 ] ], "normalized": [] }, { "id": "NCT02589353_exc_T11", "type": "Condition", "text": [ "e or", " o" ], "offsets": [ [ 123, 127 ], [ 138, 140 ] ], "normalized": [] }, { "id": "NCT02589353_exc_T12", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 142, 147 ] ], "normalized": [] }, { "id": "NCT02589353_exc_T13", "type": "Condition", "text": [ "oral disorders" ], "offsets": [ [ 148, 162 ] ], "normalized": [] }, { "id": "NCT02589353_exc_T14", "type": "Condition", "text": [ "burning mouth syndrome" ], "offsets": [ [ 170, 192 ] ], "normalized": [] }, { "id": "NCT02589353_exc_T15", "type": "Scope", "text": [ "other oral disorders" ], "offsets": [ [ 142, 162 ] ], "normalized": [] }, { "id": "NCT02589353_exc_T16", "type": "Scope", "text": [ "taste or smell loss or other oral disorders (e.g., burning mouth syndrome)" ], "offsets": [ [ 119, 193 ] ], "normalized": [] }, { "id": "NCT02589353_exc_T17", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 198, 205 ] ], "normalized": [] }, { "id": "NCT02589353_exc_T18", "type": "Condition", "text": [ "oral lesions" ], "offsets": [ [ 206, 218 ] ], "normalized": [] }, { "id": "NCT02589353_exc_T19", "type": "Condition", "text": [ "canker sores" ], "offsets": [ [ 220, 232 ] ], "normalized": [] }, { "id": "NCT02589353_exc_T20", "type": "Device", "text": [ "piercings" ], "offsets": [ [ 237, 246 ] ], "normalized": [] }, { "id": "NCT02589353_exc_T21", "type": "Scope", "text": [ "oral lesions, canker sores, or piercings" ], "offsets": [ [ 206, 246 ] ], "normalized": [] }, { "id": "NCT02589353_exc_T22", "type": "Observation", "text": [ "history" ], "offsets": [ [ 253, 260 ] ], "normalized": [] }, { "id": "NCT02589353_exc_T23", "type": "Condition", "text": [ "food allergy" ], "offsets": [ [ 264, 276 ] ], "normalized": [] } ]

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[ { "id": "NCT02589353_exc_R1", "type": "Has_value", "arg1_id": "NCT02589353_exc_T3", "arg2_id": "NCT02589353_exc_T2", "normalized": [] }, { "id": "NCT02589353_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02589353_exc_T13", "arg2_id": "NCT02589353_exc_T12", "normalized": [] }, { "id": "NCT02589353_exc_R3", "type": "Subsumes", "arg1_id": "NCT02589353_exc_T15", "arg2_id": "NCT02589353_exc_T14", "normalized": [] }, { "id": "NCT02589353_exc_R4", "type": "Has_temporal", "arg1_id": "NCT02589353_exc_T16", "arg2_id": "NCT02589353_exc_T9", "normalized": [] }, { "id": "NCT02589353_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02589353_exc_T21", "arg2_id": "NCT02589353_exc_T17", "normalized": [] }, { "id": "NCT02589353_exc_R6", "type": "Has_temporal", "arg1_id": "NCT02589353_exc_T23", "arg2_id": "NCT02589353_exc_T22", "normalized": [] } ]

[ { "id": "NCT02589353_inc_text", "type": "inclusion", "text": [ "self-reported healthy adults between the ages of 18-60 who are fluent in English.\n" ], "offsets": [ [ 0, 82 ] ] } ]

[ { "id": "NCT02589353_inc_T1", "type": "Condition", "text": [ "healthy" ], "offsets": [ [ 14, 21 ] ], "normalized": [] }, { "id": "NCT02589353_inc_T2", "type": "Person", "text": [ "adults" ], "offsets": [ [ 22, 28 ] ], "normalized": [] }, { "id": "NCT02589353_inc_T3", "type": "Person", "text": [ "ages" ], "offsets": [ [ 41, 45 ] ], "normalized": [] }, { "id": "NCT02589353_inc_T4", "type": "Value", "text": [ "between", "18-60" ], "offsets": [ [ 29, 36 ], [ 49, 54 ] ], "normalized": [] }, { "id": "NCT02589353_inc_T5", "type": "Observation", "text": [ "fluent in English" ], "offsets": [ [ 63, 80 ] ], "normalized": [] }, { "id": "NCT02589353_inc_T6", "type": "Qualifier", "text": [ "self-reported" ], "offsets": [ [ 0, 13 ] ], "normalized": [] } ]

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[ { "id": "NCT02589353_inc_R1", "type": "Has_value", "arg1_id": "NCT02589353_inc_T3", "arg2_id": "NCT02589353_inc_T4", "normalized": [] }, { "id": "NCT02589353_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02589353_inc_T1", "arg2_id": "NCT02589353_inc_T6", "normalized": [] } ]

[ { "id": "NCT02589691_exc_text", "type": "exclusion", "text": [ "contra-indication to inhalational induction (full stomach)\ncontra-indication to the use of rocuronium\nAmerican Society of Anesthesiologists score (ASA) III or IV\nintracranial surgery\nparental refusal\nabsence of affiliation to social security\n" ], "offsets": [ [ 0, 242 ] ] } ]

[ { "id": "NCT02589691_exc_T1", "type": "Condition", "text": [ "contra-indication" ], "offsets": [ [ 0, 17 ] ], "normalized": [] }, { "id": "NCT02589691_exc_T2", "type": "Procedure", "text": [ "inhalational induction" ], "offsets": [ [ 21, 43 ] ], "normalized": [] }, { "id": "NCT02589691_exc_T3", "type": "Qualifier", "text": [ "full stomach" ], "offsets": [ [ 45, 57 ] ], "normalized": [] }, { "id": "NCT02589691_exc_T4", "type": "Condition", "text": [ "contra-indication" ], "offsets": [ [ 59, 76 ] ], "normalized": [] }, { "id": "NCT02589691_exc_T5", "type": "Drug", "text": [ "rocuronium" ], "offsets": [ [ 91, 101 ] ], "normalized": [] }, { "id": "NCT02589691_exc_T6", "type": "Measurement", "text": [ "American Society of Anesthesiologists score (ASA)" ], "offsets": [ [ 102, 151 ] ], "normalized": [] }, { "id": "NCT02589691_exc_T7", "type": "Value", "text": [ "III" ], "offsets": [ [ 152, 155 ] ], "normalized": [] }, { "id": "NCT02589691_exc_T8", "type": "Value", "text": [ "IV" ], "offsets": [ [ 159, 161 ] ], "normalized": [] }, { "id": "NCT02589691_exc_T9", "type": "Scope", "text": [ "III or IV" ], "offsets": [ [ 152, 161 ] ], "normalized": [] }, { "id": "NCT02589691_exc_T10", "type": "Procedure", "text": [ "intracranial surgery" ], "offsets": [ [ 162, 182 ] ], "normalized": [] }, { "id": "NCT02589691_exc_T12", "type": "Observation", "text": [ "affiliation to social security" ], "offsets": [ [ 211, 241 ] ], "normalized": [] }, { "id": "NCT02589691_exc_T13", "type": "Negation", "text": [ "absence" ], "offsets": [ [ 200, 207 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02589691_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02589691_exc_T2", "arg2_id": "NCT02589691_exc_T3", "normalized": [] }, { "id": "NCT02589691_exc_R2", "type": "AND", "arg1_id": "NCT02589691_exc_T1", "arg2_id": "NCT02589691_exc_T2", "normalized": [] }, { "id": "NCT02589691_exc_R3", "type": "AND", "arg1_id": "NCT02589691_exc_T4", "arg2_id": "NCT02589691_exc_T5", "normalized": [] }, { "id": "NCT02589691_exc_R4", "type": "Has_scope", "arg1_id": "NCT02589691_exc_T6", "arg2_id": "NCT02589691_exc_T9", "normalized": [] }, { "id": "NCT02589691_exc_R5", "type": "Has_negation", "arg1_id": "NCT02589691_exc_T12", "arg2_id": "NCT02589691_exc_T13", "normalized": [] } ]

[ { "id": "NCT02589691_inc_text", "type": "inclusion", "text": [ "age <2 years\nindication of general anesthesia with tracheal intubation\ninhalational induction scheduled\nwritten informed consent of both parents\n" ], "offsets": [ [ 0, 145 ] ] } ]

[ { "id": "NCT02589691_inc_T1", "type": "Person", "text": [ "age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02589691_inc_T2", "type": "Value", "text": [ "<2 years" ], "offsets": [ [ 4, 12 ] ], "normalized": [] }, { "id": "NCT02589691_inc_T3", "type": "Procedure", "text": [ "general anesthesia" ], "offsets": [ [ 27, 45 ] ], "normalized": [] }, { "id": "NCT02589691_inc_T4", "type": "Procedure", "text": [ "tracheal intubation" ], "offsets": [ [ 51, 70 ] ], "normalized": [] }, { "id": "NCT02589691_inc_T5", "type": "Mood", "text": [ "indication" ], "offsets": [ [ 13, 23 ] ], "normalized": [] }, { "id": "NCT02589691_inc_T6", "type": "Procedure", "text": [ "inhalational induction" ], "offsets": [ [ 71, 93 ] ], "normalized": [] }, { "id": "NCT02589691_inc_T7", "type": "Mood", "text": [ "scheduled" ], "offsets": [ [ 94, 103 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02589691_inc_R1", "type": "Has_value", "arg1_id": "NCT02589691_inc_T1", "arg2_id": "NCT02589691_inc_T2", "normalized": [] }, { "id": "NCT02589691_inc_R2", "type": "AND", "arg1_id": "NCT02589691_inc_T3", "arg2_id": "NCT02589691_inc_T4", "normalized": [] }, { "id": "NCT02589691_inc_R3", "type": "Has_mood", "arg1_id": "NCT02589691_inc_T3", "arg2_id": "NCT02589691_inc_T5", "normalized": [] }, { "id": "NCT02589691_inc_R4", "type": "Has_mood", "arg1_id": "NCT02589691_inc_T6", "arg2_id": "NCT02589691_inc_T7", "normalized": [] } ]

[ { "id": "NCT02589977_exc_text", "type": "exclusion", "text": [ "Exclusion Criteria: coronary artery disease, diabetes mellitus, contraindications to cardiac magnetic resonance imaging (CMR), weight >350 lbs, inability to lie flat for imaging, anemia, contraindications to regadenoson or aminophylline\nHEALTHY: known cardiovascular disease, cardiac risk factors or use of cardiac medications\nHYPERTENSIVE: known cardiovascular disease or risk factors aside from hypertension or use of cardiac medications\nHFpEF: prior history of LVEF below 50%, acute decompensated HF, moderate or greater valvular disease, significant cardiac arrhythmias, pericardial disease, congenital heart disease, primary pulmonary hypertension\n" ], "offsets": [ [ 0, 653 ] ] } ]

[ { "id": "NCT02589977_exc_T1", "type": "Condition", "text": [ "coronary artery disease" ], "offsets": [ [ 20, 43 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T2", "type": "Condition", "text": [ "diabetes mellitus" ], "offsets": [ [ 45, 62 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T3", "type": "Condition", "text": [ "contraindications" ], "offsets": [ [ 64, 81 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T4", "type": "Procedure", "text": [ "cardiac magnetic resonance imaging (CMR)" ], "offsets": [ [ 85, 125 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T5", "type": "Measurement", "text": [ "weight" ], "offsets": [ [ 127, 133 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T6", "type": "Value", "text": [ ">350 lbs" ], "offsets": [ [ 134, 142 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T7", "type": "Observation", "text": [ "inability to lie flat for imaging" ], "offsets": [ [ 144, 177 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T8", "type": "Condition", "text": [ "anemia" ], "offsets": [ [ 179, 185 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T9", "type": "Condition", "text": [ "contraindications" ], "offsets": [ [ 187, 204 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T10", "type": "Drug", "text": [ "regadenoson" ], "offsets": [ [ 208, 219 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T11", "type": "Drug", "text": [ "aminophylline" ], "offsets": [ [ 223, 236 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T12", "type": "Scope", "text": [ "regadenoson or aminophylline" ], "offsets": [ [ 208, 236 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T13", "type": "Condition", "text": [ "HEALTHY" ], "offsets": [ [ 237, 244 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T14", "type": "Condition", "text": [ "cardiovascular disease" ], "offsets": [ [ 252, 274 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T15", "type": "Condition", "text": [ "cardiac risk factors" ], "offsets": [ [ 276, 296 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T16", "type": "Drug", "text": [ "cardiac medications" ], "offsets": [ [ 307, 326 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T17", "type": "Scope", "text": [ "cardiovascular disease, cardiac risk factors or use of cardiac medications" ], "offsets": [ [ 252, 326 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T18", "type": "Condition", "text": [ "HYPERTENSIVE" ], "offsets": [ [ 327, 339 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T19", "type": "Condition", "text": [ "cardiovascular disease" ], "offsets": [ [ 347, 369 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T20", "type": "Condition", "text": [ "rdiovascular d", "sk factors a" ], "offsets": [ [ 349, 363 ], [ 375, 387 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T21", "type": "Condition", "text": [ "rdiovascular d", "sk factors a", "om hypertension o" ], "offsets": [ [ 349, 363 ], [ 375, 387 ], [ 394, 411 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T22", "type": "Negation", "text": [ "aside from" ], "offsets": [ [ 386, 396 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T23", "type": "Drug", "text": [ "cardiac medications" ], "offsets": [ [ 420, 439 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T24", "type": "Scope", "text": [ "cardiovascular disease or risk factors aside from hypertension" ], "offsets": [ [ 347, 409 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T25", "type": "Scope", "text": [ "cardiovascular disease or risk factors aside from hypertension or use of cardiac medications" ], "offsets": [ [ 347, 439 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T26", "type": "Condition", "text": [ "HFpEF" ], "offsets": [ [ 440, 445 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T27", "type": "Observation", "text": [ "prior history of" ], "offsets": [ [ 447, 463 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T28", "type": "Measurement", "text": [ "LVEF" ], "offsets": [ [ 464, 468 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T29", "type": "Value", "text": [ "below 50%" ], "offsets": [ [ 469, 478 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T30", "type": "Qualifier", "text": [ "acute" ], "offsets": [ [ 480, 485 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T31", "type": "Condition", "text": [ "decompensated HF" ], "offsets": [ [ 486, 502 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T32", "type": "Qualifier", "text": [ "moderate" ], "offsets": [ [ 504, 512 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T33", "type": "Qualifier", "text": [ "greater" ], "offsets": [ [ 516, 523 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T34", "type": "Condition", "text": [ "valvular disease" ], "offsets": [ [ 524, 540 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T35", "type": "Scope", "text": [ "moderate or greater" ], "offsets": [ [ 504, 523 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T36", "type": "Qualifier", "text": [ "significant" ], "offsets": [ [ 542, 553 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T37", "type": "Condition", "text": [ "cardiac arrhythmias" ], "offsets": [ [ 554, 573 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T38", "type": "Condition", "text": [ "pericardial disease" ], "offsets": [ [ 575, 594 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T39", "type": "Condition", "text": [ "congenital heart disease" ], "offsets": [ [ 596, 620 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T40", "type": "Condition", "text": [ "primary pulmonary hypertension" ], "offsets": [ [ 622, 652 ] ], "normalized": [] }, { "id": "NCT02589977_exc_T41", "type": "Scope", "text": [ "prior history of LVEF below 50%, acute decompensated HF, moderate or greater valvular disease, significant cardiac arrhythmias, pericardial disease, congenital heart disease, primary pulmonary hypertension" ], "offsets": [ [ 447, 652 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02589977_exc_R1", "type": "AND", "arg1_id": "NCT02589977_exc_T3", "arg2_id": "NCT02589977_exc_T4", "normalized": [] }, { "id": "NCT02589977_exc_R2", "type": "Has_value", "arg1_id": "NCT02589977_exc_T5", "arg2_id": "NCT02589977_exc_T6", "normalized": [] }, { "id": "NCT02589977_exc_R3", "type": "Has_scope", "arg1_id": "NCT02589977_exc_T9", "arg2_id": "NCT02589977_exc_T12", "normalized": [] }, { "id": "NCT02589977_exc_R4", "type": "Has_scope", "arg1_id": "NCT02589977_exc_T13", "arg2_id": "NCT02589977_exc_T17", "normalized": [] }, { "id": "NCT02589977_exc_R5", "type": "Has_negation", "arg1_id": "NCT02589977_exc_T21", "arg2_id": "NCT02589977_exc_T22", "normalized": [] }, { "id": "NCT02589977_exc_R6", "type": "Has_scope", "arg1_id": "NCT02589977_exc_T18", "arg2_id": "NCT02589977_exc_T25", "normalized": [] }, { "id": "NCT02589977_exc_R7", "type": "Has_value", "arg1_id": "NCT02589977_exc_T28", "arg2_id": "NCT02589977_exc_T29", "normalized": [] }, { "id": "NCT02589977_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02589977_exc_T28", "arg2_id": "NCT02589977_exc_T27", "normalized": [] }, { "id": "NCT02589977_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT02589977_exc_T31", "arg2_id": "NCT02589977_exc_T30", "normalized": [] }, { "id": "NCT02589977_exc_R10", "type": "Has_scope", "arg1_id": "NCT02589977_exc_T34", "arg2_id": "NCT02589977_exc_T35", "normalized": [] }, { "id": "NCT02589977_exc_R11", "type": "Has_qualifier", "arg1_id": "NCT02589977_exc_T37", "arg2_id": "NCT02589977_exc_T36", "normalized": [] }, { "id": "NCT02589977_exc_R12", "type": "Has_scope", "arg1_id": "NCT02589977_exc_T26", "arg2_id": "NCT02589977_exc_T41", "normalized": [] } ]

[ { "id": "NCT02589977_inc_text", "type": "inclusion", "text": [ "estimated glomerular filtration rate (eGFR) > 60 ml/min\npreserved left ventricular ejection fraction (>= 50%) on echocardiography\nHEALTHY: normal cardiac structure and function on echocardiography, BP < 140/90\nHYPERTENSIVE: history of BP >140/90, 1 or more antihypertensive medications, LV ejection fraction (LVEF) at least 50%, current BP < 160/90\nHFpEF: physician-confirmed diagnosis of HF, symptomatic HF, LVEF at least 50%, elevated LV filling pressure by catheterization, echocardiographic criteria or B-type-natriuretic peptide > 100, current BP < 160/90\n" ], "offsets": [ [ 0, 561 ] ] } ]

[ { "id": "NCT02589977_inc_T1", "type": "Measurement", "text": [ "estimated glomerular filtration rate (eGFR)" ], "offsets": [ [ 0, 43 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T2", "type": "Value", "text": [ "> 60 ml/min" ], "offsets": [ [ 44, 55 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T3", "type": "Measurement", "text": [ "left ventricular ejection fraction" ], "offsets": [ [ 66, 100 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T4", "type": "Value", "text": [ "preserved" ], "offsets": [ [ 56, 65 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T5", "type": "Value", "text": [ ">= 50%" ], "offsets": [ [ 102, 108 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T6", "type": "Procedure", "text": [ "echocardiography" ], "offsets": [ [ 113, 129 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T7", "type": "Condition", "text": [ "HEALTHY" ], "offsets": [ [ 130, 137 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T8", "type": "Value", "text": [ "normal cardiac structure" ], "offsets": [ [ 139, 163 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T9", "type": "Value", "text": [ "rmal cardiac s", "nction o" ], "offsets": [ [ 141, 155 ], [ 170, 178 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T10", "type": "Procedure", "text": [ "echocardiography" ], "offsets": [ [ 180, 196 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T11", "type": "Scope", "text": [ "normal cardiac structure and function" ], "offsets": [ [ 139, 176 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T12", "type": "Measurement", "text": [ "BP" ], "offsets": [ [ 198, 200 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T13", "type": "Value", "text": [ "< 140/90" ], "offsets": [ [ 201, 209 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T14", "type": "Scope", "text": [ "normal cardiac structure and function on echocardiography, BP < 140/90" ], "offsets": [ [ 139, 209 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T15", "type": "Condition", "text": [ "HYPERTENSIVE" ], "offsets": [ [ 210, 222 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T16", "type": "Condition", "text": [ "HFpEF" ], "offsets": [ [ 349, 354 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T17", "type": "Measurement", "text": [ "BP" ], "offsets": [ [ 235, 237 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T18", "type": "Value", "text": [ ">140/90" ], "offsets": [ [ 238, 245 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T19", "type": "Observation", "text": [ "history" ], "offsets": [ [ 224, 231 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T20", "type": "Multiplier", "text": [ "1 or more" ], "offsets": [ [ 247, 256 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T21", "type": "Drug", "text": [ "antihypertensive medications" ], "offsets": [ [ 257, 285 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T22", "type": "Measurement", "text": [ "LV ejection fraction (LVEF)" ], "offsets": [ [ 287, 314 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T23", "type": "Value", "text": [ "at least 50%" ], "offsets": [ [ 315, 327 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T24", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 329, 336 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T25", "type": "Measurement", "text": [ "BP" ], "offsets": [ [ 337, 339 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T26", "type": "Value", "text": [ "< 160/90" ], "offsets": [ [ 340, 348 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T27", "type": "Scope", "text": [ "history of BP >140/90, 1 or more antihypertensive medications, LV ejection fraction (LVEF) at least 50%, current BP < 160/90" ], "offsets": [ [ 224, 348 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T28", "type": "Qualifier", "text": [ "physician-confirmed" ], "offsets": [ [ 356, 375 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T29", "type": "Condition", "text": [ "HF" ], "offsets": [ [ 389, 391 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T30", "type": "Qualifier", "text": [ "symptomatic" ], "offsets": [ [ 393, 404 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T31", "type": "Condition", "text": [ "HF" ], "offsets": [ [ 405, 407 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T32", "type": "Measurement", "text": [ "LVEF" ], "offsets": [ [ 409, 413 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T33", "type": "Value", "text": [ "at least 50%" ], "offsets": [ [ 414, 426 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T34", "type": "Value", "text": [ "elevated" ], "offsets": [ [ 428, 436 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T35", "type": "Measurement", "text": [ "LV filling pressure" ], "offsets": [ [ 437, 456 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T36", "type": "Procedure", "text": [ "catheterization" ], "offsets": [ [ 460, 475 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T38", "type": "Measurement", "text": [ "B-type-natriuretic peptide" ], "offsets": [ [ 507, 533 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T39", "type": "Value", "text": [ "> 100" ], "offsets": [ [ 534, 539 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T40", "type": "Measurement", "text": [ "current BP" ], "offsets": [ [ 541, 551 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T41", "type": "Value", "text": [ "< 160/90" ], "offsets": [ [ 552, 560 ] ], "normalized": [] }, { "id": "NCT02589977_inc_T42", "type": "Scope", "text": [ "physician-confirmed diagnosis of HF, symptomatic HF, LVEF at least 50%, elevated LV filling pressure by catheterization, echocardiographic criteria or B-type-natriuretic peptide > 100, current BP < 160/90" ], "offsets": [ [ 356, 560 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT02589977_inc_R1", "type": "Has_value", "arg1_id": "NCT02589977_inc_T1", "arg2_id": "NCT02589977_inc_T2", "normalized": [] }, { "id": "NCT02589977_inc_R2", "type": "Subsumes", "arg1_id": "NCT02589977_inc_T4", "arg2_id": "NCT02589977_inc_T5", "normalized": [] }, { "id": "NCT02589977_inc_R3", "type": "Has_value", "arg1_id": "NCT02589977_inc_T3", "arg2_id": "NCT02589977_inc_T4", "normalized": [] }, { "id": "NCT02589977_inc_R4", "type": "AND", "arg1_id": "NCT02589977_inc_T6", "arg2_id": "NCT02589977_inc_T3", "normalized": [] }, { "id": "NCT02589977_inc_R5", "type": "Has_scope", "arg1_id": "NCT02589977_inc_T10", "arg2_id": "NCT02589977_inc_T11", "normalized": [] }, { "id": "NCT02589977_inc_R6", "type": "Has_value", "arg1_id": "NCT02589977_inc_T12", "arg2_id": "NCT02589977_inc_T13", "normalized": [] }, { "id": "NCT02589977_inc_R7", "type": "Has_scope", "arg1_id": "NCT02589977_inc_T7", "arg2_id": "NCT02589977_inc_T14", "normalized": [] }, { "id": "NCT02589977_inc_R8", "type": "Has_value", "arg1_id": "NCT02589977_inc_T17", "arg2_id": "NCT02589977_inc_T18", "normalized": [] }, { "id": "NCT02589977_inc_R9", "type": "Has_multiplier", "arg1_id": "NCT02589977_inc_T21", "arg2_id": "NCT02589977_inc_T20", "normalized": [] }, { "id": "NCT02589977_inc_R10", "type": "Has_value", "arg1_id": "NCT02589977_inc_T22", "arg2_id": "NCT02589977_inc_T23", "normalized": [] }, { "id": "NCT02589977_inc_R11", "type": "Has_value", "arg1_id": "NCT02589977_inc_T25", "arg2_id": "NCT02589977_inc_T26", "normalized": [] }, { "id": "NCT02589977_inc_R12", "type": "Has_temporal", "arg1_id": "NCT02589977_inc_T25", "arg2_id": "NCT02589977_inc_T24", "normalized": [] }, { "id": "NCT02589977_inc_R13", "type": "Has_scope", "arg1_id": "NCT02589977_inc_T15", "arg2_id": "NCT02589977_inc_T27", "normalized": [] }, { "id": "NCT02589977_inc_R14", "type": "Has_qualifier", "arg1_id": "NCT02589977_inc_T31", "arg2_id": "NCT02589977_inc_T30", "normalized": [] }, { "id": "NCT02589977_inc_R15", "type": "Has_qualifier", "arg1_id": "NCT02589977_inc_T29", "arg2_id": "NCT02589977_inc_T28", "normalized": [] }, { "id": "NCT02589977_inc_R16", "type": "Has_value", "arg1_id": "NCT02589977_inc_T32", "arg2_id": "NCT02589977_inc_T33", "normalized": [] }, { "id": "NCT02589977_inc_R17", "type": "Has_value", "arg1_id": "NCT02589977_inc_T35", "arg2_id": "NCT02589977_inc_T34", "normalized": [] }, { "id": "NCT02589977_inc_R18", "type": "AND", "arg1_id": "NCT02589977_inc_T36", "arg2_id": "NCT02589977_inc_T35", "normalized": [] }, { "id": "NCT02589977_inc_R19", "type": "Has_value", "arg1_id": "NCT02589977_inc_T38", "arg2_id": "NCT02589977_inc_T39", "normalized": [] }, { "id": "NCT02589977_inc_R20", "type": "Has_value", "arg1_id": "NCT02589977_inc_T40", "arg2_id": "NCT02589977_inc_T41", "normalized": [] }, { "id": "NCT02589977_inc_R21", "type": "Has_scope", "arg1_id": "NCT02589977_inc_T16", "arg2_id": "NCT02589977_inc_T42", "normalized": [] } ]

[ { "id": "NCT02590315_exc_text", "type": "exclusion", "text": [ "Personal history of breast cancer\nA terminal illness\nPatients who are unable to give informed consent\nBreast implants\n" ], "offsets": [ [ 0, 118 ] ] } ]

[ { "id": "NCT02590315_exc_T1", "type": "Condition", "text": [ "breast cancer" ], "offsets": [ [ 20, 33 ] ], "normalized": [] }, { "id": "NCT02590315_exc_T2", "type": "Observation", "text": [ "Personal history" ], "offsets": [ [ 0, 16 ] ], "normalized": [] }, { "id": "NCT02590315_exc_T3", "type": "Condition", "text": [ "terminal illness" ], "offsets": [ [ 36, 52 ] ], "normalized": [] }, { "id": "NCT02590315_exc_T4", "type": "Observation", "text": [ "unable to give informed consent" ], "offsets": [ [ 70, 101 ] ], "normalized": [] }, { "id": "NCT02590315_exc_T5", "type": "Device", "text": [ "Breast implants" ], "offsets": [ [ 102, 117 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT02590315_inc_text", "type": "inclusion", "text": [ "Asymptomatic women 45-68 years, residents in the Piedmont Region, attending the regional breast cancer screening program\n" ], "offsets": [ [ 0, 121 ] ] } ]

[ { "id": "NCT02590315_inc_T1", "type": "Qualifier", "text": [ "Asymptomatic" ], "offsets": [ [ 0, 12 ] ], "normalized": [] }, { "id": "NCT02590315_inc_T2", "type": "Person", "text": [ "women" ], "offsets": [ [ 13, 18 ] ], "normalized": [] }, { "id": "NCT02590315_inc_T3", "type": "Value", "text": [ "45-68 years" ], "offsets": [ [ 19, 30 ] ], "normalized": [] }, { "id": "NCT02590315_inc_T4", "type": "Visit", "text": [ "Piedmont Region" ], "offsets": [ [ 49, 64 ] ], "normalized": [] }, { "id": "NCT02590315_inc_T5", "type": "Procedure", "text": [ "regional breast cancer screening program" ], "offsets": [ [ 80, 120 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT02590315_inc_R1", "type": "Has_value", "arg1_id": "NCT02590315_inc_T2", "arg2_id": "NCT02590315_inc_T3", "normalized": [] } ]

[ { "id": "NCT02590653_exc_text", "type": "exclusion", "text": [ "NA\n\n" ], "offsets": [ [ 0, 4 ] ] } ]

[]

[]

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[ { "id": "NCT02590653_inc_text", "type": "inclusion", "text": [ "Signed Informed Consent Form\nPatients having physical and mental ability to participate in the study\nPatients of both sexes aged 35 to 65 years\nPresence of documented ST-elevation myocardial infarction confirmed by ECG, as well as troponin I and CK-MB levels.\nPresence of hemodynamically relevant stenosis of one artery (i.e., the infarct-related artery) confirmed by coronary angiography (CAG), with the occlusion of other arteries not exceeding 30%.\n" ], "offsets": [ [ 0, 452 ] ] } ]

[ { "id": "NCT02590653_inc_T3", "type": "Person", "text": [ "sexes" ], "offsets": [ [ 118, 123 ] ], "normalized": [] }, { "id": "NCT02590653_inc_T4", "type": "Value", "text": [ "both" ], "offsets": [ [ 113, 117 ] ], "normalized": [] }, { "id": "NCT02590653_inc_T5", "type": "Person", "text": [ "aged" ], "offsets": [ [ 124, 128 ] ], "normalized": [] }, { "id": "NCT02590653_inc_T6", "type": "Value", "text": [ "35 to 65 years" ], "offsets": [ [ 129, 143 ] ], "normalized": [] }, { "id": "NCT02590653_inc_T7", "type": "Condition", "text": [ "ST-elevation myocardial infarction" ], "offsets": [ [ 167, 201 ] ], "normalized": [] }, { "id": "NCT02590653_inc_T8", "type": "Procedure", "text": [ "ECG" ], "offsets": [ [ 215, 218 ] ], "normalized": [] }, { "id": "NCT02590653_inc_T9", "type": "Measurement", "text": [ "troponin I" ], "offsets": [ [ 231, 241 ] ], "normalized": [] }, { "id": "NCT02590653_inc_T10", "type": "Measurement", "text": [ "CK-MB" ], "offsets": [ [ 246, 251 ] ], "normalized": [] }, { "id": "NCT02590653_inc_T11", "type": "Scope", "text": [ "ECG, as well as troponin I and CK-MB" ], "offsets": [ [ 215, 251 ] ], "normalized": [] }, { "id": "NCT02590653_inc_T12", "type": "Condition", "text": [ "osis of one", "ry (i." ], "offsets": [ [ 301, 312 ], [ 317, 323 ] ], "normalized": [] }, { "id": "NCT02590653_inc_T13", "type": "Multiplier", "text": [ "one" ], "offsets": [ [ 309, 312 ] ], "normalized": [] }, { "id": "NCT02590653_inc_T14", "type": "Condition", "text": [ "infarct-related artery" ], "offsets": [ [ 331, 353 ] ], "normalized": [] }, { "id": "NCT02590653_inc_T15", "type": "Qualifier", "text": [ "hemodynamically relevant" ], "offsets": [ [ 272, 296 ] ], "normalized": [] }, { "id": "NCT02590653_inc_T16", "type": "Procedure", "text": [ "coronary angiography" ], "offsets": [ [ 368, 388 ] ], "normalized": [] }, { "id": "NCT02590653_inc_T17", "type": "Procedure", "text": [ "CAG" ], "offsets": [ [ 390, 393 ] ], "normalized": [] }, { "id": "NCT02590653_inc_T18", "type": "Condition", "text": [ "occlusion of other arteries" ], "offsets": [ [ 405, 432 ] ], "normalized": [] }, { "id": "NCT02590653_inc_T19", "type": "Multiplier", "text": [ "not exceeding 30%" ], "offsets": [ [ 433, 450 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02590653_inc_R1", "type": "Has_value", "arg1_id": "NCT02590653_inc_T3", "arg2_id": "NCT02590653_inc_T4", "normalized": [] }, { "id": "NCT02590653_inc_R2", "type": "Has_value", "arg1_id": "NCT02590653_inc_T5", "arg2_id": "NCT02590653_inc_T6", "normalized": [] }, { "id": "NCT02590653_inc_R3", "type": "AND", "arg1_id": "NCT02590653_inc_T11", "arg2_id": "NCT02590653_inc_T7", "normalized": [] }, { "id": "NCT02590653_inc_R4", "type": "Has_multiplier", "arg1_id": "NCT02590653_inc_T12", "arg2_id": "NCT02590653_inc_T13", "normalized": [] }, { "id": "NCT02590653_inc_R5", "type": "Subsumes", "arg1_id": "NCT02590653_inc_T12", "arg2_id": "NCT02590653_inc_T14", "normalized": [] }, { "id": "NCT02590653_inc_R6", "type": "Has_qualifier", "arg1_id": "NCT02590653_inc_T12", "arg2_id": "NCT02590653_inc_T15", "normalized": [] }, { "id": "NCT02590653_inc_R7", "type": "Subsumes", "arg1_id": "NCT02590653_inc_T16", "arg2_id": "NCT02590653_inc_T17", "normalized": [] }, { "id": "NCT02590653_inc_R8", "type": "AND", "arg1_id": "NCT02590653_inc_T16", "arg2_id": "NCT02590653_inc_T12", "normalized": [] }, { "id": "NCT02590653_inc_R9", "type": "Has_multiplier", "arg1_id": "NCT02590653_inc_T18", "arg2_id": "NCT02590653_inc_T19", "normalized": [] } ]

[ { "id": "NCT02590822_exc_text", "type": "exclusion", "text": [ "• Diabetes duration >12 years\nCurrently taking more than three glucose lowering therapies\nWeight-loss of >5kg in the preceding 6 months\nStage 4 or 5 chronic kidney disease (eGFR< 30ml/min/1.73m2),\nCurrent therapy with Insulin, thiazolidinediones, steroids or atypical antipsychotic medication\nUntreated thyroid disease\nKnown macrovascular disease including coronary artery disease, stroke/TIA or peripheral vascular disease\nPresence of arrhythmia (including atrial fibrillation, atrial flutter, or 2nd or 3rd degree atrioventricular block)\nKnown heart failure\nOther clinically relevant heart disease\nInability to exercise or undertake a MRP\nAbsolute contraindication to CMR\nCardiovascular symptoms (angina, limiting dyspnoea during normal physical activity)\nInflammatory condition e.g. Connective tissue disorder, Rheumatoid arthritis\n" ], "offsets": [ [ 0, 835 ] ] } ]

[ { "id": "NCT02590822_exc_T1", "type": "Condition", "text": [ "Diabetes" ], "offsets": [ [ 2, 10 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T2", "type": "Temporal", "text": [ ">12 years" ], "offsets": [ [ 20, 29 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T3", "type": "Multiplier", "text": [ "more than three" ], "offsets": [ [ 47, 62 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T4", "type": "Procedure", "text": [ "glucose lowering therapies" ], "offsets": [ [ 63, 89 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T5", "type": "Observation", "text": [ "Weight-loss" ], "offsets": [ [ 90, 101 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T6", "type": "Value", "text": [ ">5kg" ], "offsets": [ [ 105, 109 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T7", "type": "Temporal", "text": [ "preceding 6 months" ], "offsets": [ [ 117, 135 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T8", "type": "Condition", "text": [ "chronic kidney disease" ], "offsets": [ [ 149, 171 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T9", "type": "Qualifier", "text": [ "Stage 4 or 5" ], "offsets": [ [ 136, 148 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T10", "type": "Measurement", "text": [ "eGFR" ], "offsets": [ [ 173, 177 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T11", "type": "Value", "text": [ "< 30ml/min/1.73m2" ], "offsets": [ [ 177, 194 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T12", "type": "Drug", "text": [ "Insulin" ], "offsets": [ [ 218, 225 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T13", "type": "Drug", "text": [ "thiazolidinediones" ], "offsets": [ [ 227, 245 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T14", "type": "Drug", "text": [ "steroids" ], "offsets": [ [ 247, 255 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T15", "type": "Drug", "text": [ "atypical antipsychotic medication" ], "offsets": [ [ 259, 292 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T16", "type": "Condition", "text": [ "thyroid disease" ], "offsets": [ [ 303, 318 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T17", "type": "Qualifier", "text": [ "Untreated" ], "offsets": [ [ 293, 302 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T18", "type": "Condition", "text": [ "macrovascular disease" ], "offsets": [ [ 325, 346 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T19", "type": "Condition", "text": [ "coronary artery disease" ], "offsets": [ [ 357, 380 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T20", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 382, 388 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T21", "type": "Condition", "text": [ "TIA" ], "offsets": [ [ 389, 392 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T22", "type": "Condition", "text": [ "peripheral vascular disease" ], "offsets": [ [ 396, 423 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T23", "type": "Scope", "text": [ "coronary artery disease, stroke/TIA or peripheral vascular disease" ], "offsets": [ [ 357, 423 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T24", "type": "Condition", "text": [ "arrhythmia" ], "offsets": [ [ 436, 446 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T25", "type": "Condition", "text": [ "atrial fibrillation" ], "offsets": [ [ 458, 477 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T26", "type": "Condition", "text": [ "atrial flutter" ], "offsets": [ [ 479, 493 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T27", "type": "Condition", "text": [ "3rd degree atrioventricular block" ], "offsets": [ [ 505, 538 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T28", "type": "Condition", "text": [ "3rd", "atrioventricular block)\nKnown" ], "offsets": [ [ 505, 508 ], [ 516, 545 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T29", "type": "Scope", "text": [ "atrial fibrillation, atrial flutter, or 2nd or 3rd degree atrioventricular block" ], "offsets": [ [ 458, 538 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T30", "type": "Condition", "text": [ "heart failure" ], "offsets": [ [ 546, 559 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T31", "type": "Condition", "text": [ "heart disease" ], "offsets": [ [ 586, 599 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T32", "type": "Observation", "text": [ "exercise" ], "offsets": [ [ 613, 621 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T33", "type": "Procedure", "text": [ "MRP" ], "offsets": [ [ 637, 640 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T34", "type": "Negation", "text": [ "Inability" ], "offsets": [ [ 600, 609 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T35", "type": "Scope", "text": [ "exercise or undertake a MRP" ], "offsets": [ [ 613, 640 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T36", "type": "Condition", "text": [ "contraindication" ], "offsets": [ [ 650, 666 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T37", "type": "Procedure", "text": [ "CMR" ], "offsets": [ [ 670, 673 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T38", "type": "Condition", "text": [ "Cardiovascular symptoms" ], "offsets": [ [ 674, 697 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T39", "type": "Condition", "text": [ "ting d" ], "offsets": [ [ 711, 717 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T40", "type": "Condition", "text": [ "dyspnoea" ], "offsets": [ [ 716, 724 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T41", "type": "Scope", "text": [ "angina, limiting dyspnoea" ], "offsets": [ [ 699, 724 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T42", "type": "Condition", "text": [ "Inflammatory" ], "offsets": [ [ 758, 770 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T43", "type": "Condition", "text": [ "Connective tissue disorder," ], "offsets": [ [ 786, 813 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T44", "type": "Condition", "text": [ "Rheumatoid arthritis" ], "offsets": [ [ 814, 834 ] ], "normalized": [] }, { "id": "NCT02590822_exc_T45", "type": "Scope", "text": [ "Connective tissue disorder, Rheumatoid arthritis" ], "offsets": [ [ 786, 834 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02590822_exc_R1", "type": "Has_temporal", "arg1_id": "NCT02590822_exc_T1", "arg2_id": "NCT02590822_exc_T2", "normalized": [] }, { "id": "NCT02590822_exc_R2", "type": "Has_multiplier", "arg1_id": "NCT02590822_exc_T4", "arg2_id": "NCT02590822_exc_T3", "normalized": [] }, { "id": "NCT02590822_exc_R3", "type": "Has_value", "arg1_id": "NCT02590822_exc_T5", "arg2_id": "NCT02590822_exc_T6", "normalized": [] }, { "id": "NCT02590822_exc_R4", "type": "Has_temporal", "arg1_id": "NCT02590822_exc_T5", "arg2_id": "NCT02590822_exc_T7", "normalized": [] }, { "id": "NCT02590822_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02590822_exc_T8", "arg2_id": "NCT02590822_exc_T9", "normalized": [] }, { "id": "NCT02590822_exc_R6", "type": "Has_value", "arg1_id": "NCT02590822_exc_T10", "arg2_id": "NCT02590822_exc_T11", "normalized": [] }, { "id": "NCT02590822_exc_R7", "type": "Subsumes", "arg1_id": "NCT02590822_exc_T8", "arg2_id": "NCT02590822_exc_T10", "normalized": [] }, { "id": "NCT02590822_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT02590822_exc_T16", "arg2_id": "NCT02590822_exc_T17", "normalized": [] }, { "id": "NCT02590822_exc_R9", "type": "Subsumes", "arg1_id": "NCT02590822_exc_T18", "arg2_id": "NCT02590822_exc_T23", "normalized": [] }, { "id": "NCT02590822_exc_R10", "type": "Subsumes", "arg1_id": "NCT02590822_exc_T24", "arg2_id": "NCT02590822_exc_T29", "normalized": [] }, { "id": "NCT02590822_exc_R11", "type": "Has_negation", "arg1_id": "NCT02590822_exc_T35", "arg2_id": "NCT02590822_exc_T34", "normalized": [] }, { "id": "NCT02590822_exc_R12", "type": "AND", "arg1_id": "NCT02590822_exc_T36", "arg2_id": "NCT02590822_exc_T37", "normalized": [] }, { "id": "NCT02590822_exc_R13", "type": "Has_scope", "arg1_id": "NCT02590822_exc_T38", "arg2_id": "NCT02590822_exc_T41", "normalized": [] }, { "id": "NCT02590822_exc_R14", "type": "Subsumes", "arg1_id": "NCT02590822_exc_T42", "arg2_id": "NCT02590822_exc_T45", "normalized": [] } ]

[ { "id": "NCT02590822_inc_text", "type": "inclusion", "text": [ "Capacity to provide informed consent before any trial-related activities\nEstablished T2DM (=3months)\nHbA1c = 9% if on triple therapy or = 10% on diet & exercise or monotherapy or dual therapy\nCurrent glucose lowering therapy either mono, dual or triple of any combination of metformin, sulphonylurea, DPP-IV inhibitor, GLP-1 therapy or an SGLT2 +/- diet and exercise\nPoorly managed diet controlled diabetes (with HbA1c > 6.5% , not currently taking any glucose lowering therapy, meeting BMI inclusion range)\nBody mass index > 30Kg/m2 or > 27.5 Kg/m2 (South Asian),\nDiagnosis of T2DM before the age of 60 years of age\nAge =18 and = 65 years\n" ], "offsets": [ [ 0, 640 ] ] } ]

[ { "id": "NCT02590822_inc_T2", "type": "Condition", "text": [ "T2DM" ], "offsets": [ [ 85, 89 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T3", "type": "Temporal", "text": [ "=3months" ], "offsets": [ [ 91, 99 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T4", "type": "Measurement", "text": [ "HbA1c" ], "offsets": [ [ 101, 106 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T5", "type": "Measurement", "text": [ "Capacity to provide informed consent before any trial-related activities\nEstablished T2DM (=3months)\nHbA1c = 9" ], "offsets": [ [ 0, 110 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T6", "type": "Value", "text": [ "= 9%" ], "offsets": [ [ 107, 111 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T7", "type": "Value", "text": [ "= 10%" ], "offsets": [ [ 136, 141 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T8", "type": "Scope", "text": [ "= 9% if on triple therapy or = 10%" ], "offsets": [ [ 107, 141 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T9", "type": "Procedure", "text": [ "glucose lowering therapy" ], "offsets": [ [ 200, 224 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T10", "type": "Drug", "text": [ "metformin" ], "offsets": [ [ 275, 284 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T11", "type": "Drug", "text": [ "sulphonylurea" ], "offsets": [ [ 286, 299 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T12", "type": "Drug", "text": [ "DPP-IV inhibitor," ], "offsets": [ [ 301, 318 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T13", "type": "Drug", "text": [ "GLP-1 therapy" ], "offsets": [ [ 319, 332 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T14", "type": "Drug", "text": [ "SGLT2" ], "offsets": [ [ 339, 344 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T15", "type": "Observation", "text": [ "diet" ], "offsets": [ [ 349, 353 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T16", "type": "Observation", "text": [ "exercise" ], "offsets": [ [ 358, 366 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T17", "type": "Scope", "text": [ "metformin, sulphonylurea, DPP-IV inhibitor, GLP-1 therapy or an SGLT2 +/- diet and exercise" ], "offsets": [ [ 275, 366 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T18", "type": "Condition", "text": [ "diabetes" ], "offsets": [ [ 398, 406 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T19", "type": "Measurement", "text": [ "HbA1c" ], "offsets": [ [ 413, 418 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T20", "type": "Value", "text": [ "> 6.5%" ], "offsets": [ [ 419, 425 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T21", "type": "Negation", "text": [ "not" ], "offsets": [ [ 428, 431 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T22", "type": "Procedure", "text": [ "glucose lowering therapy" ], "offsets": [ [ 453, 477 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T23", "type": "Measurement", "text": [ "Body mass index" ], "offsets": [ [ 508, 523 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T24", "type": "Value", "text": [ "> 30Kg/m2" ], "offsets": [ [ 524, 533 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T25", "type": "Value", "text": [ "> 27.5 Kg/m2" ], "offsets": [ [ 537, 549 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T26", "type": "Scope", "text": [ "> 30Kg/m2 or > 27.5 Kg/m2" ], "offsets": [ [ 524, 549 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T27", "type": "Condition", "text": [ "T2DM" ], "offsets": [ [ 578, 582 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T28", "type": "Person", "text": [ "age" ], "offsets": [ [ 594, 597 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T29", "type": "Value", "text": [ " the ", "rs of age\nAge =" ], "offsets": [ [ 589, 594 ], [ 607, 622 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T30", "type": "Person", "text": [ "Age" ], "offsets": [ [ 617, 620 ] ], "normalized": [] }, { "id": "NCT02590822_inc_T31", "type": "Value", "text": [ "=18 and = 65 years" ], "offsets": [ [ 621, 639 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT02590822_inc_R1", "type": "Has_temporal", "arg1_id": "NCT02590822_inc_T2", "arg2_id": "NCT02590822_inc_T3", "normalized": [] }, { "id": "NCT02590822_inc_R2", "type": "Has_scope", "arg1_id": "NCT02590822_inc_T4", "arg2_id": "NCT02590822_inc_T8", "normalized": [] }, { "id": "NCT02590822_inc_R3", "type": "Subsumes", "arg1_id": "NCT02590822_inc_T9", "arg2_id": "NCT02590822_inc_T17", "normalized": [] }, { "id": "NCT02590822_inc_R4", "type": "Has_value", "arg1_id": "NCT02590822_inc_T19", "arg2_id": "NCT02590822_inc_T20", "normalized": [] }, { "id": "NCT02590822_inc_R5", "type": "Subsumes", "arg1_id": "NCT02590822_inc_T18", "arg2_id": "NCT02590822_inc_T19", "normalized": [] }, { "id": "NCT02590822_inc_R6", "type": "Has_negation", "arg1_id": "NCT02590822_inc_T22", "arg2_id": "NCT02590822_inc_T21", "normalized": [] }, { "id": "NCT02590822_inc_R7", "type": "Has_scope", "arg1_id": "NCT02590822_inc_T23", "arg2_id": "NCT02590822_inc_T26", "normalized": [] }, { "id": "NCT02590822_inc_R8", "type": "Has_value", "arg1_id": "NCT02590822_inc_T28", "arg2_id": "NCT02590822_inc_T29", "normalized": [] }, { "id": "NCT02590822_inc_R9", "type": "Has_value", "arg1_id": "NCT02590822_inc_T30", "arg2_id": "NCT02590822_inc_T31", "normalized": [] } ]

[ { "id": "NCT02592980_exc_text", "type": "exclusion", "text": [ "Patients will not be included if they have reached a stable dose of warfarin, liver dysfunction, alcoholism, use of another anticoagulant, use of chemotherapy, or if they do not meet the inclusion criteria\n" ], "offsets": [ [ 0, 206 ] ] } ]

[ { "id": "NCT02592980_exc_T1", "type": "Multiplier", "text": [ "stable dose" ], "offsets": [ [ 53, 64 ] ], "normalized": [] }, { "id": "NCT02592980_exc_T2", "type": "Drug", "text": [ "warfarin" ], "offsets": [ [ 68, 76 ] ], "normalized": [] }, { "id": "NCT02592980_exc_T3", "type": "Condition", "text": [ "liver dysfunction" ], "offsets": [ [ 78, 95 ] ], "normalized": [] }, { "id": "NCT02592980_exc_T4", "type": "Condition", "text": [ "alcoholism" ], "offsets": [ [ 97, 107 ] ], "normalized": [] }, { "id": "NCT02592980_exc_T5", "type": "Qualifier", "text": [ "another" ], "offsets": [ [ 116, 123 ] ], "normalized": [] }, { "id": "NCT02592980_exc_T6", "type": "Drug", "text": [ "anticoagulant" ], "offsets": [ [ 124, 137 ] ], "normalized": [] }, { "id": "NCT02592980_exc_T7", "type": "Procedure", "text": [ "chemotherapy" ], "offsets": [ [ 146, 158 ] ], "normalized": [] } ]

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[ { "id": "NCT02592980_exc_R1", "type": "Has_multiplier", "arg1_id": "NCT02592980_exc_T2", "arg2_id": "NCT02592980_exc_T1", "normalized": [] }, { "id": "NCT02592980_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02592980_exc_T6", "arg2_id": "NCT02592980_exc_T5", "normalized": [] } ]

[ { "id": "NCT02592980_inc_text", "type": "inclusion", "text": [ "Only patients with atrial fibrillation, above 18 years, and with TTR <50% based on the last three values of INR will be included in this study.\n" ], "offsets": [ [ 0, 144 ] ] } ]

[ { "id": "NCT02592980_inc_T1", "type": "Condition", "text": [ "atrial fibrillation" ], "offsets": [ [ 19, 38 ] ], "normalized": [] }, { "id": "NCT02592980_inc_T2", "type": "Value", "text": [ "above 18 years" ], "offsets": [ [ 40, 54 ] ], "normalized": [] }, { "id": "NCT02592980_inc_T3", "type": "Person", "text": [ "years" ], "offsets": [ [ 49, 54 ] ], "normalized": [] }, { "id": "NCT02592980_inc_T4", "type": "Measurement", "text": [ "TTR" ], "offsets": [ [ 65, 68 ] ], "normalized": [] }, { "id": "NCT02592980_inc_T5", "type": "Value", "text": [ "<50%" ], "offsets": [ [ 69, 73 ] ], "normalized": [] }, { "id": "NCT02592980_inc_T6", "type": "Qualifier", "text": [ "based on the last three values of INR" ], "offsets": [ [ 74, 111 ] ], "normalized": [] } ]

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[ { "id": "NCT02592980_inc_R1", "type": "Has_value", "arg1_id": "NCT02592980_inc_T3", "arg2_id": "NCT02592980_inc_T2", "normalized": [] }, { "id": "NCT02592980_inc_R2", "type": "Has_value", "arg1_id": "NCT02592980_inc_T4", "arg2_id": "NCT02592980_inc_T5", "normalized": [] }, { "id": "NCT02592980_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT02592980_inc_T4", "arg2_id": "NCT02592980_inc_T6", "normalized": [] } ]

[ { "id": "NCT02593409_exc_text", "type": "exclusion", "text": [ "HIV infection at screening\nparticipation in previous or concurrent HIV vaccine trials\nlactating, pregnant or planning pregnancy\nrenal function impairment (serum creatinine >1.5 mg/dl), Fanconi syndrome\nabnormal liver function tests (AST/ALT > 43 U/L), liver disease, viral hepatitis, hepatitis B virus (HBV) infection\nserum phosphorus <2.2mg/dl, osteoporosis\nknown sensitivity to components of the Truvada® formulation\nany immunosuppressive treatment, such as systemic corticosteroids\nassumption of medication that interacts with Truvada®\nhigh likelihood of poor adherence to PREP and clinic attendance\nany condition that in the opinion of the attending physician could endanger the health of the participant or render her unsuitable to participate in the trial\n" ], "offsets": [ [ 0, 762 ] ] } ]

[ { "id": "NCT02593409_exc_T1", "type": "Condition", "text": [ "HIV infection" ], "offsets": [ [ 0, 13 ] ], "normalized": [] }, { "id": "NCT02593409_exc_T4", "type": "Condition", "text": [ "renal function impairment" ], "offsets": [ [ 128, 153 ] ], "normalized": [] }, { "id": "NCT02593409_exc_T5", "type": "Measurement", "text": [ "serum creatinine" ], "offsets": [ [ 155, 171 ] ], "normalized": [] }, { "id": "NCT02593409_exc_T6", "type": "Value", "text": [ ">1.5 mg/dl" ], "offsets": [ [ 172, 182 ] ], "normalized": [] }, { "id": "NCT02593409_exc_T7", "type": "Condition", "text": [ "Fanconi syndrome" ], "offsets": [ [ 185, 201 ] ], "normalized": [] }, { "id": "NCT02593409_exc_T8", "type": "Measurement", "text": [ "liver function tests" ], "offsets": [ [ 211, 231 ] ], "normalized": [] }, { "id": "NCT02593409_exc_T9", "type": "Value", "text": [ "abnormal" ], "offsets": [ [ 202, 210 ] ], "normalized": [] }, { "id": "NCT02593409_exc_T10", "type": "Measurement", "text": [ "AST" ], "offsets": [ [ 233, 236 ] ], "normalized": [] }, { "id": "NCT02593409_exc_T11", "type": "Measurement", "text": [ "ALT" ], "offsets": [ [ 237, 240 ] ], "normalized": [] }, { "id": "NCT02593409_exc_T12", "type": "Value", "text": [ "> 43 U/L" ], "offsets": [ [ 241, 249 ] ], "normalized": [] }, { "id": "NCT02593409_exc_T13", "type": "Scope", "text": [ "AST/ALT" ], "offsets": [ [ 233, 240 ] ], "normalized": [] }, { "id": "NCT02593409_exc_T14", "type": "Condition", "text": [ "liver disease" ], "offsets": [ [ 252, 265 ] ], "normalized": [] }, { "id": "NCT02593409_exc_T15", "type": "Condition", "text": [ "viral hepatitis" ], "offsets": [ [ 267, 282 ] ], "normalized": [] }, { "id": "NCT02593409_exc_T16", "type": "Condition", "text": [ "hepatitis B virus (HBV) infection" ], "offsets": [ [ 284, 317 ] ], "normalized": [] }, { "id": "NCT02593409_exc_T17", "type": "Measurement", "text": [ "serum phosphorus" ], "offsets": [ [ 318, 334 ] ], "normalized": [] }, { "id": "NCT02593409_exc_T18", "type": "Value", "text": [ "<2.2mg/dl" ], "offsets": [ [ 335, 344 ] ], "normalized": [] }, { "id": "NCT02593409_exc_T19", "type": "Condition", "text": [ "osteoporosis" ], "offsets": [ [ 346, 358 ] ], "normalized": [] }, { "id": "NCT02593409_exc_T20", "type": "Condition", "text": [ "sensitivity" ], "offsets": [ [ 365, 376 ] ], "normalized": [] }, { "id": "NCT02593409_exc_T21", "type": "Drug", "text": [ "Truvada" ], "offsets": [ [ 398, 405 ] ], "normalized": [] }, { "id": "NCT02593409_exc_T22", "type": "Procedure", "text": [ "immunosuppressive treatment" ], "offsets": [ [ 423, 450 ] ], "normalized": [] }, { "id": "NCT02593409_exc_T23", "type": "Drug", "text": [ "systemic corticosteroids" ], "offsets": [ [ 460, 484 ] ], "normalized": [] } ]

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[ { "id": "NCT02593409_exc_R1", "type": "Subsumes", "arg1_id": "NCT02593409_exc_T4", "arg2_id": "NCT02593409_exc_T5", "normalized": [] }, { "id": "NCT02593409_exc_R2", "type": "Subsumes", "arg1_id": "NCT02593409_exc_T5", "arg2_id": "NCT02593409_exc_T6", "normalized": [] }, { "id": "NCT02593409_exc_R3", "type": "Has_value", "arg1_id": "NCT02593409_exc_T5", "arg2_id": "NCT02593409_exc_T6", "normalized": [] }, { "id": "NCT02593409_exc_R4", "type": "Has_value", "arg1_id": "NCT02593409_exc_T8", "arg2_id": "NCT02593409_exc_T9", "normalized": [] }, { "id": "NCT02593409_exc_R5", "type": "Subsumes", "arg1_id": "NCT02593409_exc_T8", "arg2_id": "NCT02593409_exc_T13", "normalized": [] }, { "id": "NCT02593409_exc_R6", "type": "Has_value", "arg1_id": "NCT02593409_exc_T13", "arg2_id": "NCT02593409_exc_T12", "normalized": [] }, { "id": "NCT02593409_exc_R7", "type": "Has_value", "arg1_id": "NCT02593409_exc_T17", "arg2_id": "NCT02593409_exc_T18", "normalized": [] }, { "id": "NCT02593409_exc_R8", "type": "AND", "arg1_id": "NCT02593409_exc_T20", "arg2_id": "NCT02593409_exc_T21", "normalized": [] }, { "id": "NCT02593409_exc_R9", "type": "Subsumes", "arg1_id": "NCT02593409_exc_T22", "arg2_id": "NCT02593409_exc_T23", "normalized": [] } ]

[ { "id": "NCT02593409_inc_text", "type": "inclusion", "text": [ "age =18 at screening\nnot intending to move away from the clinic's catchment area for the next 2 years\nHIV-1 antibody negative\nreports commercial sex work\ncontact information is provided\nwritten informed consent\n" ], "offsets": [ [ 0, 211 ] ] } ]

[ { "id": "NCT02593409_inc_T1", "type": "Person", "text": [ "age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02593409_inc_T2", "type": "Value", "text": [ "=18" ], "offsets": [ [ 4, 7 ] ], "normalized": [] }, { "id": "NCT02593409_inc_T4", "type": "Measurement", "text": [ "HIV-1 antibody" ], "offsets": [ [ 102, 116 ] ], "normalized": [] }, { "id": "NCT02593409_inc_T5", "type": "Value", "text": [ "negative" ], "offsets": [ [ 117, 125 ] ], "normalized": [] }, { "id": "NCT02593409_inc_T6", "type": "Observation", "text": [ "commercial sex work" ], "offsets": [ [ 134, 153 ] ], "normalized": [] } ]

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[ { "id": "NCT02593409_inc_R1", "type": "Has_value", "arg1_id": "NCT02593409_inc_T1", "arg2_id": "NCT02593409_inc_T2", "normalized": [] }, { "id": "NCT02593409_inc_R2", "type": "Has_value", "arg1_id": "NCT02593409_inc_T4", "arg2_id": "NCT02593409_inc_T5", "normalized": [] } ]

[ { "id": "NCT02595190_exc_text", "type": "exclusion", "text": [ "1. Patients with lumbar common diseases(e.g., Lumbar disc, Lumbar spinal stenosis, Lumbar slippage, etc)\n2. Researchers think that Patients with disease may be interference results(e.g., Spinal deformity, spine fracture, ankylosing spondylitis, spinal tuberculosis and spinal infection, spinal tumor, pelvic inflammatory disease and other disease of department of gynaecology, etc)\n3. Patients with other nervous system diseases(e.g., cerebral tumor, neurinoma, trigeminal neuralgia,etc)\n4. Patients with Magnetic resonance imaging contraindication ,including claustrophobic syndrome patients\n5. Patients with recent (less than 3 years) use chemical drugs or have obvious psychological problems\n6. In the past 2 months involved in other drugs or devices clinical trials\n" ], "offsets": [ [ 0, 770 ] ] } ]

[ { "id": "NCT02595190_exc_T1", "type": "Condition", "text": [ "lumbar", "diseases" ], "offsets": [ [ 17, 23 ], [ 31, 39 ] ], "normalized": [] }, { "id": "NCT02595190_exc_T2", "type": "Condition", "text": [ "Lumbar disc" ], "offsets": [ [ 46, 57 ] ], "normalized": [] }, { "id": "NCT02595190_exc_T3", "type": "Condition", "text": [ "Lumbar spinal stenosis" ], "offsets": [ [ 59, 81 ] ], "normalized": [] }, { "id": "NCT02595190_exc_T4", "type": "Condition", "text": [ "Lumbar slippage" ], "offsets": [ [ 83, 98 ] ], "normalized": [] }, { "id": "NCT02595190_exc_T5", "type": "Scope", "text": [ "Lumbar disc, Lumbar spinal stenosis, Lumbar slippage," ], "offsets": [ [ 46, 99 ] ], "normalized": [] }, { "id": "NCT02595190_exc_T6", "type": "Condition", "text": [ "Spinal deformity" ], "offsets": [ [ 187, 203 ] ], "normalized": [] }, { "id": "NCT02595190_exc_T7", "type": "Condition", "text": [ "spine fracture," ], "offsets": [ [ 205, 220 ] ], "normalized": [] }, { "id": "NCT02595190_exc_T8", "type": "Condition", "text": [ "ankylosing spondylitis" ], "offsets": [ [ 221, 243 ] ], "normalized": [] }, { "id": "NCT02595190_exc_T9", "type": "Condition", "text": [ "spinal tuberculosis" ], "offsets": [ [ 245, 264 ] ], "normalized": [] }, { "id": "NCT02595190_exc_T10", "type": "Condition", "text": [ "spinal infection" ], "offsets": [ [ 269, 285 ] ], "normalized": [] }, { "id": "NCT02595190_exc_T11", "type": "Condition", "text": [ "spinal tumor" ], "offsets": [ [ 287, 299 ] ], "normalized": [] }, { "id": "NCT02595190_exc_T12", "type": "Condition", "text": [ "pelvic inflammatory disease" ], "offsets": [ [ 301, 328 ] ], "normalized": [] }, { "id": "NCT02595190_exc_T13", "type": "Condition", "text": [ "nervous system diseases" ], "offsets": [ [ 405, 428 ] ], "normalized": [] }, { "id": "NCT02595190_exc_T14", "type": "Condition", "text": [ "cerebral tumor" ], "offsets": [ [ 435, 449 ] ], "normalized": [] }, { "id": "NCT02595190_exc_T15", "type": "Condition", "text": [ "neurinoma" ], "offsets": [ [ 451, 460 ] ], "normalized": [] }, { "id": "NCT02595190_exc_T16", "type": "Condition", "text": [ "trigeminal neuralgia" ], "offsets": [ [ 462, 482 ] ], "normalized": [] }, { "id": "NCT02595190_exc_T17", "type": "Scope", "text": [ "cerebral tumor, neurinoma, trigeminal neuralgia" ], "offsets": [ [ 435, 482 ] ], "normalized": [] }, { "id": "NCT02595190_exc_T18", "type": "Procedure", "text": [ "Magnetic resonance imaging" ], "offsets": [ [ 505, 531 ] ], "normalized": [] }, { "id": "NCT02595190_exc_T19", "type": "Condition", "text": [ "contraindication" ], "offsets": [ [ 532, 548 ] ], "normalized": [] }, { "id": "NCT02595190_exc_T20", "type": "Condition", "text": [ "claustrophobic syndrome" ], "offsets": [ [ 560, 583 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT02595190_exc_R1", "type": "Subsumes", "arg1_id": "NCT02595190_exc_T1", "arg2_id": "NCT02595190_exc_T5", "normalized": [] }, { "id": "NCT02595190_exc_R2", "type": "Subsumes", "arg1_id": "NCT02595190_exc_T13", "arg2_id": "NCT02595190_exc_T17", "normalized": [] }, { "id": "NCT02595190_exc_R3", "type": "AND", "arg1_id": "NCT02595190_exc_T19", "arg2_id": "NCT02595190_exc_T18", "normalized": [] }, { "id": "NCT02595190_exc_R4", "type": "Subsumes", "arg1_id": "NCT02595190_exc_T19", "arg2_id": "NCT02595190_exc_T20", "normalized": [] } ]

[ { "id": "NCT02595190_inc_text", "type": "inclusion", "text": [ "1. Diagnosed with symptomatic sacral perineurial cysts(e.g., lumbosacral or perineal pain, fecal or urinary functions change, sexual function change, lower limb radiation pain, muscle abate, paresthesia, etc)\n2. Visual analog scale more than or equal to 4\n3. Signed the informed consent\n4. Years, range 18-60\n5. Self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores < 50\n6. No Congenital,Mental and other Nervous system diseases\n7. No Serious Cardiac,Pulmonary,Hepatic and Nephritic disease\n8. No history of drug allergy\n9. No pain(including dysmenorrhea) or drug use (e.g., antipyretics,sleeping pills) within the last month\n10. MRI finding of sacral perineurial cysts, but without any clinical symptoms, included in the negative control group\n11. MRI finding healthy volunteers don't have sacral perineurial cysts, included in the negative control groupblank control group\n" ], "offsets": [ [ 0, 899 ] ] } ]

[ { "id": "NCT02595190_inc_T1", "type": "Condition", "text": [ "sacral perineurial cysts(" ], "offsets": [ [ 30, 55 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T2", "type": "Qualifier", "text": [ "symptomatic" ], "offsets": [ [ 18, 29 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T3", "type": "Condition", "text": [ "perineal pain" ], "offsets": [ [ 76, 89 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T4", "type": "Condition", "text": [ "lumbosacral", "pain" ], "offsets": [ [ 61, 72 ], [ 85, 89 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T5", "type": "Condition", "text": [ "urinary functions change" ], "offsets": [ [ 100, 124 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T6", "type": "Condition", "text": [ "functions change,", "fecal" ], "offsets": [ [ 108, 125 ], [ 91, 96 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T7", "type": "Condition", "text": [ "sexual function change" ], "offsets": [ [ 126, 148 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T8", "type": "Condition", "text": [ "lower limb radiation pain" ], "offsets": [ [ 150, 175 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T9", "type": "Condition", "text": [ "muscle abate" ], "offsets": [ [ 177, 189 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T10", "type": "Condition", "text": [ "paresthesia" ], "offsets": [ [ 191, 202 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T11", "type": "Scope", "text": [ "lumbosacral or perineal pain, fecal or urinary functions change, sexual function change, lower limb radiation pain, muscle abate, paresthesia" ], "offsets": [ [ 61, 202 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T12", "type": "Measurement", "text": [ "Visual analog scale" ], "offsets": [ [ 212, 231 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T13", "type": "Value", "text": [ "more than or equal to 4" ], "offsets": [ [ 232, 255 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T15", "type": "Person", "text": [ "Years" ], "offsets": [ [ 290, 295 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T16", "type": "Value", "text": [ "18-60" ], "offsets": [ [ 303, 308 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T17", "type": "Measurement", "text": [ "Self-rating anxiety scale" ], "offsets": [ [ 312, 337 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T18", "type": "Measurement", "text": [ "SAS" ], "offsets": [ [ 339, 342 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T19", "type": "Measurement", "text": [ "self-rating depression scale" ], "offsets": [ [ 348, 376 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T20", "type": "Measurement", "text": [ "SDS" ], "offsets": [ [ 378, 381 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T21", "type": "Value", "text": [ "scores < 50" ], "offsets": [ [ 383, 394 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T22", "type": "Scope", "text": [ "Self-rating anxiety scale (SAS) and self-rating depression scale (SDS" ], "offsets": [ [ 312, 381 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T23", "type": "Condition", "text": [ "Nervous system diseases" ], "offsets": [ [ 429, 452 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T24", "type": "Negation", "text": [ "No" ], "offsets": [ [ 398, 400 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T25", "type": "Condition", "text": [ "nital,Ment", "ses\n7. N" ], "offsets": [ [ 406, 416 ], [ 449, 457 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T26", "type": "Condition", "text": [ "l and", "ses\n7." ], "offsets": [ [ 417, 422 ], [ 449, 455 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T27", "type": "Scope", "text": [ "Congenital,Mental and other Nervous system disease" ], "offsets": [ [ 401, 451 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T28", "type": "Condition", "text": [ "Nephritic disease" ], "offsets": [ [ 497, 514 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T29", "type": "Condition", "text": [ "Hepatic" ], "offsets": [ [ 485, 492 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T30", "type": "Condition", "text": [ "Pulmonary" ], "offsets": [ [ 475, 484 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T31", "type": "Condition", "text": [ "Cardiac" ], "offsets": [ [ 467, 474 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T32", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 537, 544 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T33", "type": "Drug", "text": [ "drug" ], "offsets": [ [ 532, 536 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T34", "type": "Negation", "text": [ "No" ], "offsets": [ [ 548, 550 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T35", "type": "Negation", "text": [ "No" ], "offsets": [ [ 456, 458 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T36", "type": "Negation", "text": [ "No" ], "offsets": [ [ 518, 520 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T37", "type": "Condition", "text": [ "Cardiac,Pulmonary,Hepatic" ], "offsets": [ [ 467, 492 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T38", "type": "Condition", "text": [ "pain" ], "offsets": [ [ 551, 555 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T39", "type": "Temporal", "text": [ "last month" ], "offsets": [ [ 639, 649 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T40", "type": "Condition", "text": [ "dysmenorrhea" ], "offsets": [ [ 566, 578 ] ], "normalized": [] }, { "id": "NCT02595190_inc_T41", "type": "Drug", "text": [ "drug" ], "offsets": [ [ 583, 587 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02595190_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT02595190_inc_T1", "arg2_id": "NCT02595190_inc_T2", "normalized": [] }, { "id": "NCT02595190_inc_R2", "type": "Subsumes", "arg1_id": "NCT02595190_inc_T1", "arg2_id": "NCT02595190_inc_T11", "normalized": [] }, { "id": "NCT02595190_inc_R3", "type": "Has_value", "arg1_id": "NCT02595190_inc_T12", "arg2_id": "NCT02595190_inc_T13", "normalized": [] }, { "id": "NCT02595190_inc_R4", "type": "Has_value", "arg1_id": "NCT02595190_inc_T15", "arg2_id": "NCT02595190_inc_T16", "normalized": [] }, { "id": "NCT02595190_inc_R5", "type": "Subsumes", "arg1_id": "NCT02595190_inc_T17", "arg2_id": "NCT02595190_inc_T18", "normalized": [] }, { "id": "NCT02595190_inc_R6", "type": "AND", "arg1_id": "NCT02595190_inc_T19", "arg2_id": "NCT02595190_inc_T20", "normalized": [] }, { "id": "NCT02595190_inc_R7", "type": "Has_value", "arg1_id": "NCT02595190_inc_T22", "arg2_id": "NCT02595190_inc_T21", "normalized": [] }, { "id": "NCT02595190_inc_R8", "type": "Has_negation", "arg1_id": "NCT02595190_inc_T27", "arg2_id": "NCT02595190_inc_T24", "normalized": [] }, { "id": "NCT02595190_inc_R9", "type": "AND", "arg1_id": "NCT02595190_inc_T32", "arg2_id": "NCT02595190_inc_T33", "normalized": [] }, { "id": "NCT02595190_inc_R10", "type": "Has_negation", "arg1_id": "NCT02595190_inc_T37", "arg2_id": "NCT02595190_inc_T35", "normalized": [] }, { "id": "NCT02595190_inc_R11", "type": "Has_negation", "arg1_id": "NCT02595190_inc_T33", "arg2_id": "NCT02595190_inc_T36", "normalized": [] }, { "id": "NCT02595190_inc_R12", "type": "AND", "arg1_id": "NCT02595190_inc_T40", "arg2_id": "NCT02595190_inc_T38", "normalized": [] }, { "id": "NCT02595190_inc_R13", "type": "Has_negation", "arg1_id": "NCT02595190_inc_T38", "arg2_id": "NCT02595190_inc_T34", "normalized": [] }, { "id": "NCT02595190_inc_R14", "type": "Has_temporal", "arg1_id": "NCT02595190_inc_T41", "arg2_id": "NCT02595190_inc_T39", "normalized": [] } ]

[ { "id": "NCT02596555_exc_text", "type": "exclusion", "text": [ "Pregnancy (a negative serum or urine pregnancy test should be available for women of child-bearing potential before study inclusion) or lactation\nWomen of childbearing potential who do not practice a medically accepted highly effective contraception during the trial and one month beyond\nHistory of hypersensitivity to the investigational medicinal product or to any drug with similar chemical structure or to any excipient present in the pharmaceutical form of the investigational medicinal product\nParticipation in another clinical trial during the present clinical trial or within the last three months\nMedical or psychological condition that would not permit completion of the trial or signing of informed consent\nUse of a fibrinolytic agent, surgical thrombectomy, interventional (catheter-directed) thrombus aspiration or lysis, or use of a cava filter to treat the index episode of PE\nTreatment with any therapeutically dosed anticoagulant for more than 48 hours prior to enrolment\nNeed for long-term treatment with a low molecular weight heparin, vitamin K antagonists or NOAC, for an indication other than the index PE episode, or for antiplatelet agents except acetylsalicylic acid at a dosage =100 mg/day;\nActive bleeding or known significant bleeding risk (e.g., gastrointestinal ulcer, malignant neoplasms, injuries or recent surgeries of the brain, spinal cord or eyes, recent intracranial bleedings, known or suspected esophagus varices, aneurysms or intraspinal or intracranial vascular abnormalities)\nArtificial heart valves requiring treatment with an anticoagulant\nRenal insufficiency with estimated creatinine clearance <30 ml/min/1.73m2\nChronic liver disease with aminotransferase levels two times or more above the local upper limit of normal range\nConcomitant administration of strong inhibitors of P-glycoprotein like ketoconazole, cyclosporin, itraconazole or dronedarone\nUnwillingness or inability to adhere to treatment or to the follow-up visits\nLife expectancy less than 6 months\n" ], "offsets": [ [ 0, 2009 ] ] } ]

[ { "id": "NCT02596555_exc_T6", "type": "Drug", "text": [ "fibrinolytic agent" ], "offsets": [ [ 727, 745 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T7", "type": "Procedure", "text": [ "surgical thrombectomy," ], "offsets": [ [ 747, 769 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T8", "type": "Procedure", "text": [ "thrombus aspiration" ], "offsets": [ [ 805, 824 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T9", "type": "Procedure", "text": [ "bus aspi", ", or" ], "offsets": [ [ 810, 818 ], [ 833, 837 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T10", "type": "Procedure", "text": [ "cava filter" ], "offsets": [ [ 847, 858 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T11", "type": "Condition", "text": [ "PE" ], "offsets": [ [ 889, 891 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T12", "type": "Scope", "text": [ "fibrinolytic agent, surgical thrombectomy, interventional (catheter-directed) thrombus aspiration or lysis, or use of a cava filter" ], "offsets": [ [ 727, 858 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T13", "type": "Drug", "text": [ "anticoagulant" ], "offsets": [ [ 933, 946 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T14", "type": "Qualifier", "text": [ "therapeutically" ], "offsets": [ [ 911, 926 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T15", "type": "Temporal", "text": [ "more than 48 hours prior to enrolment" ], "offsets": [ [ 951, 988 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T16", "type": "Reference_point", "text": [ "enrolment" ], "offsets": [ [ 979, 988 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T17", "type": "Qualifier", "text": [ "long-term" ], "offsets": [ [ 998, 1007 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T18", "type": "Drug", "text": [ "low molecular weight heparin" ], "offsets": [ [ 1025, 1053 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T19", "type": "Drug", "text": [ "vitamin K antagonists" ], "offsets": [ [ 1055, 1076 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T20", "type": "Drug", "text": [ "NOAC" ], "offsets": [ [ 1080, 1084 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T21", "type": "Condition", "text": [ "PE episode" ], "offsets": [ [ 1125, 1135 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T22", "type": "Drug", "text": [ "antiplatelet agents" ], "offsets": [ [ 1144, 1163 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T23", "type": "Negation", "text": [ "except" ], "offsets": [ [ 1164, 1170 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T24", "type": "Negation", "text": [ "other" ], "offsets": [ [ 1104, 1109 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T25", "type": "Qualifier", "text": [ "index" ], "offsets": [ [ 1119, 1124 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T26", "type": "Scope", "text": [ "ow molecular weight heparin, vitamin K antagonists or NOAC" ], "offsets": [ [ 1026, 1084 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T27", "type": "Drug", "text": [ "acetylsalicylic acid" ], "offsets": [ [ 1171, 1191 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T28", "type": "Multiplier", "text": [ "=100 mg/day;" ], "offsets": [ [ 1204, 1216 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T29", "type": "Scope", "text": [ "antiplatelet agents except acetylsalicylic acid at a dosage =100 mg/day" ], "offsets": [ [ 1144, 1215 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T30", "type": "Scope", "text": [ "low molecular weight heparin, vitamin K antagonists or NOAC, for an indication other than the index PE episode, or for antiplatelet agents except acetylsalicylic acid at a dosage =100 mg/day;" ], "offsets": [ [ 1025, 1216 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T31", "type": "Condition", "text": [ "Active bleeding" ], "offsets": [ [ 1217, 1232 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T32", "type": "Observation", "text": [ "bleeding risk" ], "offsets": [ [ 1254, 1267 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T33", "type": "Qualifier", "text": [ "significant" ], "offsets": [ [ 1242, 1253 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T34", "type": "Condition", "text": [ "gastrointestinal ulcer" ], "offsets": [ [ 1275, 1297 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T35", "type": "Condition", "text": [ "malignant neoplasms" ], "offsets": [ [ 1299, 1318 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T36", "type": "Condition", "text": [ "injuries" ], "offsets": [ [ 1320, 1328 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T37", "type": "Procedure", "text": [ "surgeries" ], "offsets": [ [ 1339, 1348 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T38", "type": "Qualifier", "text": [ "brain" ], "offsets": [ [ 1356, 1361 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T39", "type": "Qualifier", "text": [ "spinal cord" ], "offsets": [ [ 1363, 1374 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T40", "type": "Qualifier", "text": [ "eyes" ], "offsets": [ [ 1378, 1382 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T41", "type": "Scope", "text": [ "brain, spinal cord or eyes" ], "offsets": [ [ 1356, 1382 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T42", "type": "Condition", "text": [ "intracranial bleedings" ], "offsets": [ [ 1391, 1413 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T43", "type": "Condition", "text": [ "esophagus varices" ], "offsets": [ [ 1434, 1451 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T44", "type": "Condition", "text": [ "aneurysms" ], "offsets": [ [ 1453, 1462 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T45", "type": "Condition", "text": [ "vascular abnormalities)" ], "offsets": [ [ 1494, 1517 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T46", "type": "Qualifier", "text": [ "intracranial" ], "offsets": [ [ 1481, 1493 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T47", "type": "Qualifier", "text": [ "intraspinal" ], "offsets": [ [ 1466, 1477 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T48", "type": "Scope", "text": [ "intraspinal or intracranial" ], "offsets": [ [ 1466, 1493 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T49", "type": "Scope", "text": [ "gastrointestinal ulcer, malignant neoplasms, injuries or recent surgeries of the brain, spinal cord or eyes, recent intracranial bleedings, known or suspected esophagus varices, aneurysms or intraspinal or intracranial vascular abnormalities" ], "offsets": [ [ 1275, 1516 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T50", "type": "Device", "text": [ "Artificial heart valves" ], "offsets": [ [ 1518, 1541 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T51", "type": "Drug", "text": [ "anticoagulant" ], "offsets": [ [ 1570, 1583 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T52", "type": "Condition", "text": [ "Renal insufficiency" ], "offsets": [ [ 1584, 1603 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T53", "type": "Measurement", "text": [ "estimated creatinine clearance" ], "offsets": [ [ 1609, 1639 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T54", "type": "Value", "text": [ "<30 ml/min/1.73m2" ], "offsets": [ [ 1640, 1657 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T55", "type": "Condition", "text": [ "Chronic liver disease" ], "offsets": [ [ 1658, 1679 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T56", "type": "Measurement", "text": [ "aminotransferase" ], "offsets": [ [ 1685, 1701 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T57", "type": "Value", "text": [ "two times or more above the local upper limit of normal range" ], "offsets": [ [ 1709, 1770 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T58", "type": "Drug", "text": [ "inhibitors of P-glycoprotein" ], "offsets": [ [ 1808, 1836 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T60", "type": "Drug", "text": [ "ketoconazole" ], "offsets": [ [ 1842, 1854 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T61", "type": "Drug", "text": [ "cyclosporin" ], "offsets": [ [ 1856, 1867 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T62", "type": "Drug", "text": [ "itraconazole" ], "offsets": [ [ 1869, 1881 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T63", "type": "Drug", "text": [ "dronedarone" ], "offsets": [ [ 1885, 1896 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T59", "type": "Scope", "text": [ "ketoconazole, cyclosporin, itraconazole or dronedarone" ], "offsets": [ [ 1842, 1896 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T65", "type": "Observation", "text": [ "Life expectancy" ], "offsets": [ [ 1974, 1989 ] ], "normalized": [] }, { "id": "NCT02596555_exc_T66", "type": "Value", "text": [ "less than 6 months" ], "offsets": [ [ 1990, 2008 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02596555_exc_R1", "type": "AND", "arg1_id": "NCT02596555_exc_T12", "arg2_id": "NCT02596555_exc_T11", "normalized": [] }, { "id": "NCT02596555_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02596555_exc_T13", "arg2_id": "NCT02596555_exc_T14", "normalized": [] }, { "id": "NCT02596555_exc_R3", "type": "Has_index", "arg1_id": "NCT02596555_exc_T15", "arg2_id": "NCT02596555_exc_T16", "normalized": [] }, { "id": "NCT02596555_exc_R4", "type": "Has_temporal", "arg1_id": "NCT02596555_exc_T13", "arg2_id": "NCT02596555_exc_T15", "normalized": [] }, { "id": "NCT02596555_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02596555_exc_T21", "arg2_id": "NCT02596555_exc_T25", "normalized": [] }, { "id": "NCT02596555_exc_R6", "type": "Has_negation", "arg1_id": "NCT02596555_exc_T21", "arg2_id": "NCT02596555_exc_T24", "normalized": [] }, { "id": "NCT02596555_exc_R8", "type": "AND", "arg1_id": "NCT02596555_exc_T26", "arg2_id": "NCT02596555_exc_T21", "normalized": [] }, { "id": "NCT02596555_exc_R10", "type": "Has_negation", "arg1_id": "NCT02596555_exc_T27", "arg2_id": "NCT02596555_exc_T23", "normalized": [] }, { "id": "NCT02596555_exc_R9", "type": "Has_multiplier", "arg1_id": "NCT02596555_exc_T22", "arg2_id": "NCT02596555_exc_T28", "normalized": [] }, { "id": "NCT02596555_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT02596555_exc_T30", "arg2_id": "NCT02596555_exc_T17", "normalized": [] }, { "id": "NCT02596555_exc_R11", "type": "Has_qualifier", "arg1_id": "NCT02596555_exc_T32", "arg2_id": "NCT02596555_exc_T33", "normalized": [] }, { "id": "NCT02596555_exc_R12", "type": "Has_scope", "arg1_id": "NCT02596555_exc_T45", "arg2_id": "NCT02596555_exc_T48", "normalized": [] }, { "id": "NCT02596555_exc_R13", "type": "Has_scope", "arg1_id": "NCT02596555_exc_T37", "arg2_id": "NCT02596555_exc_T41", "normalized": [] }, { "id": "NCT02596555_exc_R14", "type": "Subsumes", "arg1_id": "NCT02596555_exc_T32", "arg2_id": "NCT02596555_exc_T49", "normalized": [] }, { "id": "NCT02596555_exc_R15", "type": "AND", "arg1_id": "NCT02596555_exc_T50", "arg2_id": "NCT02596555_exc_T51", "normalized": [] }, { "id": "NCT02596555_exc_R16", "type": "Has_value", "arg1_id": "NCT02596555_exc_T53", "arg2_id": "NCT02596555_exc_T54", "normalized": [] }, { "id": "NCT02596555_exc_R17", "type": "AND", "arg1_id": "NCT02596555_exc_T52", "arg2_id": "NCT02596555_exc_T53", "normalized": [] }, { "id": "NCT02596555_exc_R18", "type": "Has_value", "arg1_id": "NCT02596555_exc_T56", "arg2_id": "NCT02596555_exc_T57", "normalized": [] }, { "id": "NCT02596555_exc_R19", "type": "AND", "arg1_id": "NCT02596555_exc_T55", "arg2_id": "NCT02596555_exc_T56", "normalized": [] }, { "id": "NCT02596555_exc_R20", "type": "Subsumes", "arg1_id": "NCT02596555_exc_T58", "arg2_id": "NCT02596555_exc_T59", "normalized": [] }, { "id": "NCT02596555_exc_R21", "type": "Has_value", "arg1_id": "NCT02596555_exc_T65", "arg2_id": "NCT02596555_exc_T66", "normalized": [] } ]

[ { "id": "NCT02596555_inc_text", "type": "inclusion", "text": [ "Age =18 years\nObjectively confirmed diagnosis of acute PE by multidetector CT angiography, ventilation/perfusion lung scan, or selective invasive pulmonary angiography, according to established diagnostic criteria, with or without symptomatic deep vein thrombosis\nAbsence of hemodynamic collapse, or decompensation, at presentation; Hemodynamic collapse or decompensation\nAt least one sign of RV pressure overload/dysfunction on CT angiography or echocardiography\nSigns of myocardial injury as indicated by elevated troponin levels\nSigns of (RV) failure as indicated by NT-proBNP levels >600 pg/ml at baseline.\nAbility of the subject to understand the character and individual consequences of the clinical trial; signed and dated informed consent of the subject available before the start of any specific trial procedures\n" ], "offsets": [ [ 0, 822 ] ] } ]

[ { "id": "NCT02596555_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T2", "type": "Value", "text": [ "=18 years" ], "offsets": [ [ 4, 13 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T3", "type": "Qualifier", "text": [ "acute" ], "offsets": [ [ 49, 54 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T4", "type": "Condition", "text": [ "PE" ], "offsets": [ [ 55, 57 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T5", "type": "Procedure", "text": [ "CT angiography" ], "offsets": [ [ 75, 89 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T6", "type": "Procedure", "text": [ "ventilation/perfusion lung scan" ], "offsets": [ [ 91, 122 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T7", "type": "Procedure", "text": [ "invasive pulmonary angiography," ], "offsets": [ [ 137, 168 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T8", "type": "Condition", "text": [ "deep vein thrombosis" ], "offsets": [ [ 243, 263 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T9", "type": "Scope", "text": [ "CT angiography, ventilation/perfusion lung scan, or selective invasive pulmonary angiography" ], "offsets": [ [ 75, 167 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T10", "type": "Condition", "text": [ "hemodynamic collapse" ], "offsets": [ [ 275, 295 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T11", "type": "Negation", "text": [ "Absence" ], "offsets": [ [ 264, 271 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T12", "type": "Condition", "text": [ "modynamic c", "compensation," ], "offsets": [ [ 277, 288 ], [ 302, 315 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T13", "type": "Scope", "text": [ "hemodynamic collapse, or decompensation" ], "offsets": [ [ 275, 314 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T14", "type": "Multiplier", "text": [ "At least one" ], "offsets": [ [ 372, 384 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T15", "type": "Condition", "text": [ "sign of RV pressure overload" ], "offsets": [ [ 385, 413 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T16", "type": "Condition", "text": [ "n of RV pressure ov", "function on" ], "offsets": [ [ 388, 407 ], [ 417, 428 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T17", "type": "Procedure", "text": [ "CT angiography" ], "offsets": [ [ 429, 443 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T18", "type": "Procedure", "text": [ "echocardiography" ], "offsets": [ [ 447, 463 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T19", "type": "Scope", "text": [ "CT angiography or echocardiography" ], "offsets": [ [ 429, 463 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T20", "type": "Scope", "text": [ "sign of RV pressure overload/dysfunction" ], "offsets": [ [ 385, 425 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T21", "type": "Measurement", "text": [ "troponin levels" ], "offsets": [ [ 516, 531 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T22", "type": "Value", "text": [ "elevated" ], "offsets": [ [ 507, 515 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T23", "type": "Condition", "text": [ "myocardial injury" ], "offsets": [ [ 473, 490 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T24", "type": "Condition", "text": [ "RV) failure" ], "offsets": [ [ 542, 553 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T25", "type": "Measurement", "text": [ "NT-proBNP levels" ], "offsets": [ [ 570, 586 ] ], "normalized": [] }, { "id": "NCT02596555_inc_T26", "type": "Value", "text": [ ">600 pg/ml" ], "offsets": [ [ 587, 597 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02596555_inc_R1", "type": "Has_value", "arg1_id": "NCT02596555_inc_T1", "arg2_id": "NCT02596555_inc_T2", "normalized": [] }, { "id": "NCT02596555_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02596555_inc_T4", "arg2_id": "NCT02596555_inc_T3", "normalized": [] }, { "id": "NCT02596555_inc_R3", "type": "AND", "arg1_id": "NCT02596555_inc_T9", "arg2_id": "NCT02596555_inc_T4", "normalized": [] }, { "id": "NCT02596555_inc_R4", "type": "Has_negation", "arg1_id": "NCT02596555_inc_T13", "arg2_id": "NCT02596555_inc_T11", "normalized": [] }, { "id": "NCT02596555_inc_R5", "type": "Has_multiplier", "arg1_id": "NCT02596555_inc_T20", "arg2_id": "NCT02596555_inc_T14", "normalized": [] }, { "id": "NCT02596555_inc_R6", "type": "Has_scope", "arg1_id": "NCT02596555_inc_T19", "arg2_id": "NCT02596555_inc_T20", "normalized": [] }, { "id": "NCT02596555_inc_R7", "type": "Has_value", "arg1_id": "NCT02596555_inc_T21", "arg2_id": "NCT02596555_inc_T22", "normalized": [] }, { "id": "NCT02596555_inc_R8", "type": "AND", "arg1_id": "NCT02596555_inc_T23", "arg2_id": "NCT02596555_inc_T21", "normalized": [] }, { "id": "NCT02596555_inc_R9", "type": "Has_value", "arg1_id": "NCT02596555_inc_T25", "arg2_id": "NCT02596555_inc_T26", "normalized": [] }, { "id": "NCT02596555_inc_R10", "type": "AND", "arg1_id": "NCT02596555_inc_T24", "arg2_id": "NCT02596555_inc_T25", "normalized": [] } ]

[ { "id": "NCT02600000_exc_text", "type": "exclusion", "text": [ "Unstable angina;\nMyocardial infarction and heart surgery up to three months before the survey;\nChronic respiratory diseases;\nHemodynamic instability;\nTrauma recent face, nausea and vomiting.\nOrthopedic and neurological diseases that may preclude the achievement of the cardiopulmonary test and Cardiac Rehabilitation exercises;\nPsychological and / or cognitive impairments that restrict them to respond to questionnaires;\n" ], "offsets": [ [ 0, 422 ] ] } ]

[ { "id": "NCT02600000_exc_T1", "type": "Condition", "text": [ "Unstable angina" ], "offsets": [ [ 0, 15 ] ], "normalized": [] }, { "id": "NCT02600000_exc_T2", "type": "Condition", "text": [ "Myocardial infarction" ], "offsets": [ [ 17, 38 ] ], "normalized": [] }, { "id": "NCT02600000_exc_T3", "type": "Procedure", "text": [ "heart surgery" ], "offsets": [ [ 43, 56 ] ], "normalized": [] }, { "id": "NCT02600000_exc_T4", "type": "Temporal", "text": [ "up to three months before the survey" ], "offsets": [ [ 57, 93 ] ], "normalized": [] }, { "id": "NCT02600000_exc_T5", "type": "Scope", "text": [ "Myocardial infarction and heart surgery" ], "offsets": [ [ 17, 56 ] ], "normalized": [] }, { "id": "NCT02600000_exc_T6", "type": "Condition", "text": [ "Chronic respiratory diseases" ], "offsets": [ [ 95, 123 ] ], "normalized": [] }, { "id": "NCT02600000_exc_T7", "type": "Condition", "text": [ "Hemodynamic instability" ], "offsets": [ [ 125, 148 ] ], "normalized": [] }, { "id": "NCT02600000_exc_T8", "type": "Condition", "text": [ "Trauma" ], "offsets": [ [ 150, 156 ] ], "normalized": [] }, { "id": "NCT02600000_exc_T9", "type": "Condition", "text": [ "nausea" ], "offsets": [ [ 170, 176 ] ], "normalized": [] }, { "id": "NCT02600000_exc_T10", "type": "Condition", "text": [ "vomiting" ], "offsets": [ [ 181, 189 ] ], "normalized": [] }, { "id": "NCT02600000_exc_T11", "type": "Condition", "text": [ "neurological diseases" ], "offsets": [ [ 206, 227 ] ], "normalized": [] }, { "id": "NCT02600000_exc_T12", "type": "Condition", "text": [ "Orthopedic" ], "offsets": [ [ 191, 201 ] ], "normalized": [] }, { "id": "NCT02600000_exc_T13", "type": "Qualifier", "text": [ "preclude the achievement of the cardiopulmonary test and Cardiac Rehabilitation exercises" ], "offsets": [ [ 237, 326 ] ], "normalized": [] }, { "id": "NCT02600000_exc_T14", "type": "Condition", "text": [ "cognitive impairments" ], "offsets": [ [ 351, 372 ] ], "normalized": [] }, { "id": "NCT02600000_exc_T15", "type": "Qualifier", "text": [ "restrict them to respond to questionnaires" ], "offsets": [ [ 378, 420 ] ], "normalized": [] }, { "id": "NCT02600000_exc_T16", "type": "Condition", "text": [ "logical and /", "ments that" ], "offsets": [ [ 334, 347 ], [ 367, 377 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02600000_exc_R1", "type": "Has_temporal", "arg1_id": "NCT02600000_exc_T5", "arg2_id": "NCT02600000_exc_T4", "normalized": [] }, { "id": "NCT02600000_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02600000_exc_T11", "arg2_id": "NCT02600000_exc_T13", "normalized": [] }, { "id": "NCT02600000_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02600000_exc_T12", "arg2_id": "NCT02600000_exc_T13", "normalized": [] }, { "id": "NCT02600000_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT02600000_exc_T16", "arg2_id": "NCT02600000_exc_T15", "normalized": [] }, { "id": "NCT02600000_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02600000_exc_T14", "arg2_id": "NCT02600000_exc_T15", "normalized": [] } ]

[ { "id": "NCT02600000_inc_text", "type": "inclusion", "text": [ "Diagnosis of Heart Failure;\nLower left ventricular ejection fraction 45% (LVEF <45%) assessed by simple and recent echocardiogram;\nFunctional Class II and III by the New York Heart Association (NYHA)\nClinically stable;\nEx-smokers over five years;\nMaximal inspiratory pressure (MIP) <70% of predicted;\nForced expiratory volume/Forced vital capacity (FEV1 / FVC) > 70% of predicted;\n" ], "offsets": [ [ 0, 381 ] ] } ]

[ { "id": "NCT02600000_inc_T1", "type": "Condition", "text": [ "Heart Failure" ], "offsets": [ [ 13, 26 ] ], "normalized": [] }, { "id": "NCT02600000_inc_T2", "type": "Measurement", "text": [ "Lower left ventricular ejection fraction" ], "offsets": [ [ 28, 68 ] ], "normalized": [] }, { "id": "NCT02600000_inc_T3", "type": "Value", "text": [ "45%" ], "offsets": [ [ 69, 72 ] ], "normalized": [] }, { "id": "NCT02600000_inc_T4", "type": "Measurement", "text": [ "LVEF" ], "offsets": [ [ 74, 78 ] ], "normalized": [] }, { "id": "NCT02600000_inc_T5", "type": "Value", "text": [ "<45%" ], "offsets": [ [ 79, 83 ] ], "normalized": [] }, { "id": "NCT02600000_inc_T6", "type": "Scope", "text": [ "LVEF <45%" ], "offsets": [ [ 74, 83 ] ], "normalized": [] }, { "id": "NCT02600000_inc_T7", "type": "Scope", "text": [ "Lower left ventricular ejection fraction 45%" ], "offsets": [ [ 28, 72 ] ], "normalized": [] }, { "id": "NCT02600000_inc_T8", "type": "Procedure", "text": [ "echocardiogram" ], "offsets": [ [ 115, 129 ] ], "normalized": [] }, { "id": "NCT02600000_inc_T9", "type": "Temporal", "text": [ "recent" ], "offsets": [ [ 108, 114 ] ], "normalized": [] }, { "id": "NCT02600000_inc_T10", "type": "Measurement", "text": [ "New York Heart Association (NYHA)" ], "offsets": [ [ 166, 199 ] ], "normalized": [] }, { "id": "NCT02600000_inc_T11", "type": "Value", "text": [ "Class II and III" ], "offsets": [ [ 142, 158 ] ], "normalized": [] }, { "id": "NCT02600000_inc_T12", "type": "Condition", "text": [ "Clinically stable" ], "offsets": [ [ 200, 217 ] ], "normalized": [] }, { "id": "NCT02600000_inc_T13", "type": "Condition", "text": [ "Ex-smokers" ], "offsets": [ [ 219, 229 ] ], "normalized": [] }, { "id": "NCT02600000_inc_T14", "type": "Temporal", "text": [ "over five years" ], "offsets": [ [ 230, 245 ] ], "normalized": [] }, { "id": "NCT02600000_inc_T15", "type": "Measurement", "text": [ "Maximal inspiratory pressure (MIP)" ], "offsets": [ [ 247, 281 ] ], "normalized": [] }, { "id": "NCT02600000_inc_T16", "type": "Value", "text": [ "<70% of predicted" ], "offsets": [ [ 282, 299 ] ], "normalized": [] }, { "id": "NCT02600000_inc_T17", "type": "Measurement", "text": [ "Forced expiratory volume/Forced vital capacity (FEV1 / FVC)" ], "offsets": [ [ 301, 360 ] ], "normalized": [] }, { "id": "NCT02600000_inc_T18", "type": "Value", "text": [ "> 70% of predicted" ], "offsets": [ [ 361, 379 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02600000_inc_R1", "type": "Has_value", "arg1_id": "NCT02600000_inc_T2", "arg2_id": "NCT02600000_inc_T3", "normalized": [] }, { "id": "NCT02600000_inc_R2", "type": "Has_value", "arg1_id": "NCT02600000_inc_T4", "arg2_id": "NCT02600000_inc_T5", "normalized": [] }, { "id": "NCT02600000_inc_R3", "type": "Subsumes", "arg1_id": "NCT02600000_inc_T7", "arg2_id": "NCT02600000_inc_T6", "normalized": [] }, { "id": "NCT02600000_inc_R4", "type": "Has_scope", "arg1_id": "NCT02600000_inc_T8", "arg2_id": "NCT02600000_inc_T7", "normalized": [] }, { "id": "NCT02600000_inc_R5", "type": "Has_temporal", "arg1_id": "NCT02600000_inc_T8", "arg2_id": "NCT02600000_inc_T9", "normalized": [] }, { "id": "NCT02600000_inc_R6", "type": "Has_value", "arg1_id": "NCT02600000_inc_T10", "arg2_id": "NCT02600000_inc_T11", "normalized": [] }, { "id": "NCT02600000_inc_R7", "type": "Has_temporal", "arg1_id": "NCT02600000_inc_T13", "arg2_id": "NCT02600000_inc_T14", "normalized": [] }, { "id": "NCT02600000_inc_R8", "type": "Has_value", "arg1_id": "NCT02600000_inc_T15", "arg2_id": "NCT02600000_inc_T16", "normalized": [] }, { "id": "NCT02600000_inc_R9", "type": "Has_value", "arg1_id": "NCT02600000_inc_T17", "arg2_id": "NCT02600000_inc_T18", "normalized": [] } ]

[ { "id": "NCT02601157_exc_text", "type": "exclusion", "text": [ "1. High risk profiles for ischemic adverse events such as A. ST-segment elevation myocardial infarction (STEMI) B. Patients with cardiogenic shock or concomitant severe decompensated heart failure C. Myocardial infarction or stent thrombosis in spite of the maintenance of antiplatelet therapy D. Restenosis in stented segments or previous sites of balloon angioplasty 2. Patients who cannot follow allocated DAPT schedule due to the planned surgery or elective procedure within 3 months after the stenting 3. Recent history of major surgery or evident events of gastrointestinal bleeding within 1 month from the procedure 4. Patients on anticoagulation therapy with warfarin or other anticoagulants 5. Life expectancy less than 1 year (such as malignancies or other chronic systemic diseases) 6. Pregnant women 7. Past history of allergy or other contraindications for the following medications/materials: aspirin, clopidogrel, heparin, cobalt chromium, sirolimus\n" ], "offsets": [ [ 0, 965 ] ] } ]

[ { "id": "NCT02601157_exc_T8", "type": "Condition", "text": [ "ischemic adverse events" ], "offsets": [ [ 26, 49 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T9", "type": "Condition", "text": [ "High risk profiles" ], "offsets": [ [ 3, 21 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T10", "type": "Condition", "text": [ "ST-segment elevation myocardial infarction (STEMI)" ], "offsets": [ [ 61, 111 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T11", "type": "Condition", "text": [ "cardiogenic shock" ], "offsets": [ [ 129, 146 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T12", "type": "Condition", "text": [ "heart failure" ], "offsets": [ [ 183, 196 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T13", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 162, 168 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T14", "type": "Qualifier", "text": [ "decompensated" ], "offsets": [ [ 169, 182 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T15", "type": "Scope", "text": [ "A. ST-segment elevation myocardial infarction (STEMI) B. Patients with cardiogenic shock or concomitant severe decompensated heart failure C. Myocardial infarction or stent thrombosis in spite of the maintenance of antiplatelet therapy D. Restenosis in stented segments or previous sites of balloon angioplasty" ], "offsets": [ [ 58, 368 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T16", "type": "Scope", "text": [ "High risk profiles for ischemic adverse events" ], "offsets": [ [ 3, 49 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T17", "type": "Condition", "text": [ "Myocardial infarction" ], "offsets": [ [ 200, 221 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T18", "type": "Condition", "text": [ "stent thrombosis" ], "offsets": [ [ 225, 241 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T19", "type": "Drug", "text": [ "antiplatelet therapy" ], "offsets": [ [ 273, 293 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T20", "type": "Scope", "text": [ "Myocardial infarction or stent thrombosis" ], "offsets": [ [ 200, 241 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T21", "type": "Scope", "text": [ "C. Myocardial infarction or stent thrombosis in spite of the maintenance of antiplatelet therapy" ], "offsets": [ [ 197, 293 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T22", "type": "Condition", "text": [ "Restenosis" ], "offsets": [ [ 297, 307 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T23", "type": "Mood", "text": [ "planned" ], "offsets": [ [ 434, 441 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T24", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 442, 449 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T25", "type": "Qualifier", "text": [ "elective" ], "offsets": [ [ 453, 461 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T26", "type": "Procedure", "text": [ "procedure" ], "offsets": [ [ 462, 471 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T27", "type": "Scope", "text": [ "surgery or elective procedure" ], "offsets": [ [ 442, 471 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T28", "type": "Temporal", "text": [ "within 3 months after the stenting" ], "offsets": [ [ 472, 506 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T29", "type": "Condition", "text": [ "cannot follow allocated DAPT schedule" ], "offsets": [ [ 385, 422 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T30", "type": "Procedure", "text": [ "major surgery" ], "offsets": [ [ 528, 541 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T31", "type": "Condition", "text": [ "events of gastrointestinal bleeding" ], "offsets": [ [ 553, 588 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T32", "type": "Temporal", "text": [ "within 1 month from the procedure" ], "offsets": [ [ 589, 622 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T33", "type": "Scope", "text": [ "major surgery or evident events of gastrointestinal bleeding" ], "offsets": [ [ 528, 588 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T34", "type": "Procedure", "text": [ "anticoagulation therapy" ], "offsets": [ [ 638, 661 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T35", "type": "Drug", "text": [ "warfarin" ], "offsets": [ [ 667, 675 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T36", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 679, 684 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T37", "type": "Drug", "text": [ "anticoagulants" ], "offsets": [ [ 685, 699 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T38", "type": "Scope", "text": [ "warfarin or other anticoagulants" ], "offsets": [ [ 667, 699 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T39", "type": "Observation", "text": [ "Life expectancy" ], "offsets": [ [ 703, 718 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T40", "type": "Value", "text": [ "less than 1 year" ], "offsets": [ [ 719, 735 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T41", "type": "Condition", "text": [ "malignancies" ], "offsets": [ [ 745, 757 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T42", "type": "Condition", "text": [ "chronic systemic diseases" ], "offsets": [ [ 767, 792 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T43", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 761, 766 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T44", "type": "Scope", "text": [ "malignancies or other chronic systemic diseases" ], "offsets": [ [ 745, 792 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T45", "type": "Scope", "text": [ "Life expectancy less than 1 year" ], "offsets": [ [ 703, 735 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T46", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 797, 805 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T47", "type": "Person", "text": [ "women" ], "offsets": [ [ 806, 811 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T48", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 831, 838 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T49", "type": "Condition", "text": [ "contraindications" ], "offsets": [ [ 848, 865 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T50", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 842, 847 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T51", "type": "Drug", "text": [ "aspirin" ], "offsets": [ [ 907, 914 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T52", "type": "Drug", "text": [ "clopidogrel" ], "offsets": [ [ 916, 927 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T53", "type": "Drug", "text": [ "heparin" ], "offsets": [ [ 929, 936 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T54", "type": "Drug", "text": [ "cobalt chromium" ], "offsets": [ [ 938, 953 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T55", "type": "Drug", "text": [ "sirolimus" ], "offsets": [ [ 955, 964 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T56", "type": "Scope", "text": [ "aspirin, clopidogrel, heparin, cobalt chromium, sirolimus" ], "offsets": [ [ 907, 964 ] ], "normalized": [] }, { "id": "NCT02601157_exc_T57", "type": "Scope", "text": [ "allergy or other contraindications" ], "offsets": [ [ 831, 865 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02601157_exc_R1", "type": "AND", "arg1_id": "NCT02601157_exc_T9", "arg2_id": "NCT02601157_exc_T8", "normalized": [] }, { "id": "NCT02601157_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02601157_exc_T12", "arg2_id": "NCT02601157_exc_T14", "normalized": [] }, { "id": "NCT02601157_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02601157_exc_T12", "arg2_id": "NCT02601157_exc_T13", "normalized": [] }, { "id": "NCT02601157_exc_R4", "type": "Subsumes", "arg1_id": "NCT02601157_exc_T16", "arg2_id": "NCT02601157_exc_T15", "normalized": [] }, { "id": "NCT02601157_exc_R5", "type": "AND", "arg1_id": "NCT02601157_exc_T20", "arg2_id": "NCT02601157_exc_T19", "normalized": [] }, { "id": "NCT02601157_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02601157_exc_T26", "arg2_id": "NCT02601157_exc_T25", "normalized": [] }, { "id": "NCT02601157_exc_R7", "type": "Has_mood", "arg1_id": "NCT02601157_exc_T27", "arg2_id": "NCT02601157_exc_T23", "normalized": [] }, { "id": "NCT02601157_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02601157_exc_T27", "arg2_id": "NCT02601157_exc_T28", "normalized": [] }, { "id": "NCT02601157_exc_R9", "type": "Has_scope", "arg1_id": "NCT02601157_exc_T29", "arg2_id": "NCT02601157_exc_T27", "normalized": [] }, { "id": "NCT02601157_exc_R10", "type": "Has_temporal", "arg1_id": "NCT02601157_exc_T33", "arg2_id": "NCT02601157_exc_T32", "normalized": [] }, { "id": "NCT02601157_exc_R11", "type": "Has_qualifier", "arg1_id": "NCT02601157_exc_T37", "arg2_id": "NCT02601157_exc_T36", "normalized": [] }, { "id": "NCT02601157_exc_R12", "type": "Has_scope", "arg1_id": "NCT02601157_exc_T34", "arg2_id": "NCT02601157_exc_T38", "normalized": [] }, { "id": "NCT02601157_exc_R13", "type": "Has_value", "arg1_id": "NCT02601157_exc_T39", "arg2_id": "NCT02601157_exc_T40", "normalized": [] }, { "id": "NCT02601157_exc_R14", "type": "Has_qualifier", "arg1_id": "NCT02601157_exc_T42", "arg2_id": "NCT02601157_exc_T43", "normalized": [] }, { "id": "NCT02601157_exc_R15", "type": "Subsumes", "arg1_id": "NCT02601157_exc_T45", "arg2_id": "NCT02601157_exc_T44", "normalized": [] }, { "id": "NCT02601157_exc_R16", "type": "AND", "arg1_id": "NCT02601157_exc_T47", "arg2_id": "NCT02601157_exc_T46", "normalized": [] }, { "id": "NCT02601157_exc_R17", "type": "Has_qualifier", "arg1_id": "NCT02601157_exc_T49", "arg2_id": "NCT02601157_exc_T50", "normalized": [] }, { "id": "NCT02601157_exc_R18", "type": "AND", "arg1_id": "NCT02601157_exc_T49", "arg2_id": "NCT02601157_exc_T48", "normalized": [] }, { "id": "NCT02601157_exc_R19", "type": "Has_scope", "arg1_id": "NCT02601157_exc_T57", "arg2_id": "NCT02601157_exc_T56", "normalized": [] } ]

[ { "id": "NCT02601157_inc_text", "type": "inclusion", "text": [ "Patients with de novo stenotic lesions who are suitable for coronary stenting with drug-eluting stent\n" ], "offsets": [ [ 0, 102 ] ] } ]

[ { "id": "NCT02601157_inc_T1", "type": "Qualifier", "text": [ "de novo" ], "offsets": [ [ 14, 21 ] ], "normalized": [] }, { "id": "NCT02601157_inc_T2", "type": "Condition", "text": [ "stenotic lesions" ], "offsets": [ [ 22, 38 ] ], "normalized": [] }, { "id": "NCT02601157_inc_T3", "type": "Mood", "text": [ "suitable" ], "offsets": [ [ 47, 55 ] ], "normalized": [] }, { "id": "NCT02601157_inc_T4", "type": "Procedure", "text": [ "coronary stenting" ], "offsets": [ [ 60, 77 ] ], "normalized": [] }, { "id": "NCT02601157_inc_T5", "type": "Device", "text": [ "drug-eluting stent" ], "offsets": [ [ 83, 101 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02601157_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT02601157_inc_T2", "arg2_id": "NCT02601157_inc_T1", "normalized": [] }, { "id": "NCT02601157_inc_R2", "type": "AND", "arg1_id": "NCT02601157_inc_T4", "arg2_id": "NCT02601157_inc_T5", "normalized": [] }, { "id": "NCT02601157_inc_R3", "type": "Has_mood", "arg1_id": "NCT02601157_inc_T4", "arg2_id": "NCT02601157_inc_T3", "normalized": [] } ]

[ { "id": "NCT02604459_exc_text", "type": "exclusion", "text": [ "Inability to follow directions or comprehend the English language\nSevere uncorrected visual or auditory handicaps\nDelirium at screening or baseline\nEmergency surgery\n" ], "offsets": [ [ 0, 166 ] ] } ]

[ { "id": "NCT02604459_exc_T1", "type": "Observation", "text": [ "Inability to follow directions" ], "offsets": [ [ 0, 30 ] ], "normalized": [] }, { "id": "NCT02604459_exc_T2", "type": "Observation", "text": [ "Inability to", "comprehend the English language" ], "offsets": [ [ 0, 12 ], [ 34, 65 ] ], "normalized": [] }, { "id": "NCT02604459_exc_T3", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 66, 72 ] ], "normalized": [] }, { "id": "NCT02604459_exc_T4", "type": "Qualifier", "text": [ "uncorrected" ], "offsets": [ [ 73, 84 ] ], "normalized": [] }, { "id": "NCT02604459_exc_T5", "type": "Condition", "text": [ "auditory handicaps" ], "offsets": [ [ 95, 113 ] ], "normalized": [] }, { "id": "NCT02604459_exc_T6", "type": "Condition", "text": [ "andicaps", "isual" ], "offsets": [ [ 105, 113 ], [ 86, 91 ] ], "normalized": [] }, { "id": "NCT02604459_exc_T7", "type": "Scope", "text": [ "visual or auditory handicaps" ], "offsets": [ [ 85, 113 ] ], "normalized": [] }, { "id": "NCT02604459_exc_T8", "type": "Temporal", "text": [ "at screening" ], "offsets": [ [ 123, 135 ] ], "normalized": [] }, { "id": "NCT02604459_exc_T9", "type": "Temporal", "text": [ " ", "seline\nE" ], "offsets": [ [ 125, 126 ], [ 141, 149 ] ], "normalized": [] }, { "id": "NCT02604459_exc_T10", "type": "Condition", "text": [ "Delirium" ], "offsets": [ [ 114, 122 ] ], "normalized": [] }, { "id": "NCT02604459_exc_T11", "type": "Scope", "text": [ "at screening or baseline" ], "offsets": [ [ 123, 147 ] ], "normalized": [] }, { "id": "NCT02604459_exc_T12", "type": "Procedure", "text": [ "Emergency surgery" ], "offsets": [ [ 148, 165 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02604459_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02604459_exc_T7", "arg2_id": "NCT02604459_exc_T4", "normalized": [] }, { "id": "NCT02604459_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02604459_exc_T7", "arg2_id": "NCT02604459_exc_T3", "normalized": [] }, { "id": "NCT02604459_exc_R3", "type": "Has_scope", "arg1_id": "NCT02604459_exc_T10", "arg2_id": "NCT02604459_exc_T11", "normalized": [] } ]

[ { "id": "NCT02604459_inc_text", "type": "inclusion", "text": [ "Subject or legal representative has voluntarily signed the informed consent approved by the Institutional Review Board,\nHip fracture surgery scheduled under general anesthesia\nSubject is 65 years or older on the day of surgery\n" ], "offsets": [ [ 0, 227 ] ] } ]

[ { "id": "NCT02604459_inc_T2", "type": "Procedure", "text": [ "Hip fracture surgery" ], "offsets": [ [ 120, 140 ] ], "normalized": [] }, { "id": "NCT02604459_inc_T3", "type": "Procedure", "text": [ "general anesthesia" ], "offsets": [ [ 157, 175 ] ], "normalized": [] }, { "id": "NCT02604459_inc_T4", "type": "Value", "text": [ "65 years or older" ], "offsets": [ [ 187, 204 ] ], "normalized": [] }, { "id": "NCT02604459_inc_T5", "type": "Temporal", "text": [ "on the day of surgery" ], "offsets": [ [ 205, 226 ] ], "normalized": [] }, { "id": "NCT02604459_inc_T6", "type": "Reference_point", "text": [ "the day of surgery" ], "offsets": [ [ 208, 226 ] ], "normalized": [] }, { "id": "NCT02604459_inc_T7", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 219, 226 ] ], "normalized": [] }, { "id": "NCT02604459_inc_T8", "type": "Person", "text": [ "older" ], "offsets": [ [ 199, 204 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT02604459_inc_R2", "type": "Has_index", "arg1_id": "NCT02604459_inc_T5", "arg2_id": "NCT02604459_inc_T6", "normalized": [] }, { "id": "NCT02604459_inc_R3", "type": "Has_value", "arg1_id": "NCT02604459_inc_T8", "arg2_id": "NCT02604459_inc_T4", "normalized": [] }, { "id": "NCT02604459_inc_R4", "type": "Has_temporal", "arg1_id": "NCT02604459_inc_T4", "arg2_id": "NCT02604459_inc_T5", "normalized": [] } ]

[ { "id": "NCT02606565_exc_text", "type": "exclusion", "text": [ "Newborns with severe congenital anomalies\nNewborns with infection of the umbilical cord at birth\n" ], "offsets": [ [ 0, 97 ] ] } ]

[ { "id": "NCT02606565_exc_T1", "type": "Person", "text": [ "Newborns" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT02606565_exc_T2", "type": "Condition", "text": [ "severe congenital anomalies" ], "offsets": [ [ 14, 41 ] ], "normalized": [] }, { "id": "NCT02606565_exc_T3", "type": "Person", "text": [ "Newborns" ], "offsets": [ [ 42, 50 ] ], "normalized": [] }, { "id": "NCT02606565_exc_T4", "type": "Condition", "text": [ "infection of the umbilical cord" ], "offsets": [ [ 56, 87 ] ], "normalized": [] }, { "id": "NCT02606565_exc_T5", "type": "Temporal", "text": [ "at birth" ], "offsets": [ [ 88, 96 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02606565_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02606565_exc_T4", "arg2_id": "NCT02606565_exc_T5", "normalized": [] } ]

[ { "id": "NCT02606565_inc_text", "type": "inclusion", "text": [ "Newborns weighing 1.5kg or more at birth\n" ], "offsets": [ [ 0, 41 ] ] } ]

[ { "id": "NCT02606565_inc_T1", "type": "Person", "text": [ "Newborns" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT02606565_inc_T2", "type": "Measurement", "text": [ "weighing" ], "offsets": [ [ 9, 17 ] ], "normalized": [] }, { "id": "NCT02606565_inc_T3", "type": "Value", "text": [ "1.5kg or more" ], "offsets": [ [ 18, 31 ] ], "normalized": [] }, { "id": "NCT02606565_inc_T4", "type": "Temporal", "text": [ "at birth" ], "offsets": [ [ 32, 40 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02606565_inc_R1", "type": "Has_value", "arg1_id": "NCT02606565_inc_T2", "arg2_id": "NCT02606565_inc_T3", "normalized": [] }, { "id": "NCT02606565_inc_R2", "type": "Has_temporal", "arg1_id": "NCT02606565_inc_T2", "arg2_id": "NCT02606565_inc_T4", "normalized": [] } ]

[ { "id": "NCT02607163_exc_text", "type": "exclusion", "text": [ "NA\n\n" ], "offsets": [ [ 0, 4 ] ] } ]

[]

[]

[]

[]

[ { "id": "NCT02607163_inc_text", "type": "inclusion", "text": [ "the patients undergoing ascending, arch and/or proximal descending aorta surgery with cardiopulmonary bypass\n20 - 100 yrs old\n" ], "offsets": [ [ 0, 126 ] ] } ]

[ { "id": "NCT02607163_inc_T1", "type": "Procedure", "text": [ "ascending", "aorta surgery" ], "offsets": [ [ 24, 33 ], [ 67, 80 ] ], "normalized": [] }, { "id": "NCT02607163_inc_T2", "type": "Procedure", "text": [ "arch", "aorta surgery" ], "offsets": [ [ 35, 39 ], [ 67, 80 ] ], "normalized": [] }, { "id": "NCT02607163_inc_T3", "type": "Procedure", "text": [ "proximal descending aorta surgery" ], "offsets": [ [ 47, 80 ] ], "normalized": [] }, { "id": "NCT02607163_inc_T4", "type": "Procedure", "text": [ "cardiopulmonary bypass" ], "offsets": [ [ 86, 108 ] ], "normalized": [] }, { "id": "NCT02607163_inc_T5", "type": "Person", "text": [ "old" ], "offsets": [ [ 122, 125 ] ], "normalized": [] }, { "id": "NCT02607163_inc_T6", "type": "Value", "text": [ "20 - 100 yrs" ], "offsets": [ [ 109, 121 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02607163_inc_R1", "type": "Has_value", "arg1_id": "NCT02607163_inc_T5", "arg2_id": "NCT02607163_inc_T6", "normalized": [] } ]

[ { "id": "NCT02607319_exc_text", "type": "exclusion", "text": [ "Evidence of low ovarian reserve by at least one of the following: AMH = 1,5 ng/mL and/or basal CD 3 FSH = 10 mIU/mL and/or basal CD 3 Estradiol = 60 ng/mL and/or previous egg collection yield = 3 oocytes.\nPreexisting medical condition (thyroid disease, diabetes mellitus, hypertension, pulmonary conditions, cardiac condition…).\nSevere male factor infertility (Total motile sperm count < 5 million/ml and/or normal WHO morphology <20%).\nHypersensitivity to Heparin or its derivatives.\nAcquired thrombophilia.\nActive hemorrhage or increased risk of bleeding due to impairment of homeostasis.\nSevere impairment of liver or pancreatic function.\nSevere renal insufficiency (Creatinine Clearance < 30 ml/min).\nInjuries to or operations on the central nervous system, eyes and ears within the last 2 months.\nDisseminated Intravascular Coagulation (DIC) attributable to heparin-induced thrombocytopenia.\nAcute bacterial endocarditis and endocarditis lenta.\nAny organic lesion with high risk of bleeding (e.g.: active peptic ulcer, hemorrhagic stroke, cerebral aneurysm or cerebral neoplasms).\n" ], "offsets": [ [ 0, 1086 ] ] } ]

[ { "id": "NCT02607319_exc_T1", "type": "Condition", "text": [ "low ovarian reserve" ], "offsets": [ [ 12, 31 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T3", "type": "Measurement", "text": [ "AMH" ], "offsets": [ [ 66, 69 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T2", "type": "Value", "text": [ "= 1,5 ng/mL" ], "offsets": [ [ 70, 81 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T4", "type": "Measurement", "text": [ "basal CD 3 FSH" ], "offsets": [ [ 89, 103 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T5", "type": "Value", "text": [ "= 10 mIU/mL" ], "offsets": [ [ 104, 115 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T6", "type": "Measurement", "text": [ "basal CD 3 Estradiol" ], "offsets": [ [ 123, 143 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T7", "type": "Value", "text": [ "= 60 ng/mL" ], "offsets": [ [ 144, 154 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T8", "type": "Measurement", "text": [ "egg collection yield" ], "offsets": [ [ 171, 191 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T9", "type": "Value", "text": [ "= 3 oocytes" ], "offsets": [ [ 192, 203 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T10", "type": "Scope", "text": [ "AMH = 1,5 ng/mL and/or basal CD 3 FSH = 10 mIU/mL and/or basal CD 3 Estradiol = 60 ng/mL and/or previous egg collection yield = 3 oocytes" ], "offsets": [ [ 66, 203 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T11", "type": "Condition", "text": [ "thyroid disease" ], "offsets": [ [ 236, 251 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T12", "type": "Condition", "text": [ "diabetes mellitus" ], "offsets": [ [ 253, 270 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T13", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 272, 284 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T14", "type": "Condition", "text": [ "pulmonary conditions" ], "offsets": [ [ 286, 306 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T15", "type": "Condition", "text": [ "cardiac condition" ], "offsets": [ [ 308, 325 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T16", "type": "Condition", "text": [ "male factor infertility" ], "offsets": [ [ 336, 359 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T17", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 329, 335 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T18", "type": "Measurement", "text": [ "Total motile sperm count" ], "offsets": [ [ 361, 385 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T19", "type": "Value", "text": [ "< 5 million/ml" ], "offsets": [ [ 386, 400 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T20", "type": "Measurement", "text": [ "normal WHO morphology" ], "offsets": [ [ 408, 429 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T21", "type": "Value", "text": [ "<20%" ], "offsets": [ [ 430, 434 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T22", "type": "Scope", "text": [ "Total motile sperm count < 5 million/ml and/or normal WHO morphology <20%" ], "offsets": [ [ 361, 434 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T23", "type": "Condition", "text": [ "Hypersensitivity" ], "offsets": [ [ 437, 453 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T24", "type": "Drug", "text": [ "Heparin" ], "offsets": [ [ 457, 464 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T25", "type": "Condition", "text": [ "thrombophilia" ], "offsets": [ [ 494, 507 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T26", "type": "Qualifier", "text": [ "Acquired" ], "offsets": [ [ 485, 493 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T27", "type": "Condition", "text": [ "Active hemorrhage" ], "offsets": [ [ 509, 526 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T28", "type": "Observation", "text": [ "risk of bleeding" ], "offsets": [ [ 540, 556 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T29", "type": "Qualifier", "text": [ "increased" ], "offsets": [ [ 530, 539 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T30", "type": "Condition", "text": [ "impairment of homeostasis" ], "offsets": [ [ 564, 589 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T31", "type": "Condition", "text": [ "impairment of liver" ], "offsets": [ [ 598, 617 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T32", "type": "Condition", "text": [ "ment of liver", "atic function.\nSeve" ], "offsets": [ [ 604, 617 ], [ 627, 646 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T33", "type": "Scope", "text": [ "impairment of liver or pancreatic function" ], "offsets": [ [ 598, 640 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T34", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 591, 597 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T35", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 642, 648 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T36", "type": "Condition", "text": [ "renal insufficiency" ], "offsets": [ [ 649, 668 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T37", "type": "Measurement", "text": [ "Creatinine Clearance" ], "offsets": [ [ 670, 690 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T38", "type": "Value", "text": [ "< 30 ml/min" ], "offsets": [ [ 691, 702 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T39", "type": "Procedure", "text": [ "operations" ], "offsets": [ [ 720, 730 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T40", "type": "Condition", "text": [ "Injuries" ], "offsets": [ [ 705, 713 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T41", "type": "Qualifier", "text": [ "central nervous system" ], "offsets": [ [ 738, 760 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T42", "type": "Qualifier", "text": [ "eyes" ], "offsets": [ [ 762, 766 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T43", "type": "Qualifier", "text": [ "ears" ], "offsets": [ [ 771, 775 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T44", "type": "Temporal", "text": [ "last 2 months" ], "offsets": [ [ 787, 800 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T45", "type": "Scope", "text": [ "central nervous system, eyes and ears" ], "offsets": [ [ 738, 775 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T46", "type": "Scope", "text": [ "Injuries to or operations" ], "offsets": [ [ 705, 730 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T47", "type": "Condition", "text": [ "Disseminated Intravascular Coagulation" ], "offsets": [ [ 802, 840 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T48", "type": "Condition", "text": [ "DIC" ], "offsets": [ [ 842, 845 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T49", "type": "Condition", "text": [ "heparin-induced thrombocytopenia" ], "offsets": [ [ 863, 895 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T50", "type": "Condition", "text": [ "endocarditis lenta" ], "offsets": [ [ 930, 948 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T51", "type": "Condition", "text": [ "Acute bacterial endocarditis" ], "offsets": [ [ 897, 925 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T52", "type": "Condition", "text": [ "organic lesion" ], "offsets": [ [ 954, 968 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T53", "type": "Observation", "text": [ "risk of bleeding" ], "offsets": [ [ 979, 995 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T54", "type": "Qualifier", "text": [ "high" ], "offsets": [ [ 974, 978 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T55", "type": "Condition", "text": [ "active peptic ulcer" ], "offsets": [ [ 1003, 1022 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T56", "type": "Condition", "text": [ "hemorrhagic stroke" ], "offsets": [ [ 1024, 1042 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T57", "type": "Condition", "text": [ "cerebral aneurysm" ], "offsets": [ [ 1044, 1061 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T58", "type": "Condition", "text": [ "cerebral neoplasms" ], "offsets": [ [ 1065, 1083 ] ], "normalized": [] }, { "id": "NCT02607319_exc_T59", "type": "Scope", "text": [ "active peptic ulcer, hemorrhagic stroke, cerebral aneurysm or cerebral neoplasms" ], "offsets": [ [ 1003, 1083 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02607319_exc_R1", "type": "Has_value", "arg1_id": "NCT02607319_exc_T3", "arg2_id": "NCT02607319_exc_T2", "normalized": [] }, { "id": "NCT02607319_exc_R2", "type": "Has_value", "arg1_id": "NCT02607319_exc_T4", "arg2_id": "NCT02607319_exc_T5", "normalized": [] }, { "id": "NCT02607319_exc_R3", "type": "Has_value", "arg1_id": "NCT02607319_exc_T6", "arg2_id": "NCT02607319_exc_T7", "normalized": [] }, { "id": "NCT02607319_exc_R4", "type": "Has_value", "arg1_id": "NCT02607319_exc_T8", "arg2_id": "NCT02607319_exc_T9", "normalized": [] }, { "id": "NCT02607319_exc_R5", "type": "Subsumes", "arg1_id": "NCT02607319_exc_T1", "arg2_id": "NCT02607319_exc_T10", "normalized": [] }, { "id": "NCT02607319_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02607319_exc_T16", "arg2_id": "NCT02607319_exc_T17", "normalized": [] }, { "id": "NCT02607319_exc_R7", "type": "Has_value", "arg1_id": "NCT02607319_exc_T18", "arg2_id": "NCT02607319_exc_T19", "normalized": [] }, { "id": "NCT02607319_exc_R8", "type": "Has_value", "arg1_id": "NCT02607319_exc_T20", "arg2_id": "NCT02607319_exc_T21", "normalized": [] }, { "id": "NCT02607319_exc_R9", "type": "Subsumes", "arg1_id": "NCT02607319_exc_T16", "arg2_id": "NCT02607319_exc_T22", "normalized": [] }, { "id": "NCT02607319_exc_R10", "type": "AND", "arg1_id": "NCT02607319_exc_T23", "arg2_id": "NCT02607319_exc_T24", "normalized": [] }, { "id": "NCT02607319_exc_R11", "type": "Has_qualifier", "arg1_id": "NCT02607319_exc_T25", "arg2_id": "NCT02607319_exc_T26", "normalized": [] }, { "id": "NCT02607319_exc_R12", "type": "Has_qualifier", "arg1_id": "NCT02607319_exc_T28", "arg2_id": "NCT02607319_exc_T29", "normalized": [] }, { "id": "NCT02607319_exc_R13", "type": "AND", "arg1_id": "NCT02607319_exc_T28", "arg2_id": "NCT02607319_exc_T30", "normalized": [] }, { "id": "NCT02607319_exc_R14", "type": "Has_qualifier", "arg1_id": "NCT02607319_exc_T33", "arg2_id": "NCT02607319_exc_T34", "normalized": [] }, { "id": "NCT02607319_exc_R15", "type": "Has_qualifier", "arg1_id": "NCT02607319_exc_T36", "arg2_id": "NCT02607319_exc_T35", "normalized": [] }, { "id": "NCT02607319_exc_R16", "type": "Has_value", "arg1_id": "NCT02607319_exc_T37", "arg2_id": "NCT02607319_exc_T38", "normalized": [] }, { "id": "NCT02607319_exc_R17", "type": "Subsumes", "arg1_id": "NCT02607319_exc_T36", "arg2_id": "NCT02607319_exc_T37", "normalized": [] }, { "id": "NCT02607319_exc_R18", "type": "Has_scope", "arg1_id": "NCT02607319_exc_T46", "arg2_id": "NCT02607319_exc_T45", "normalized": [] }, { "id": "NCT02607319_exc_R19", "type": "Has_temporal", "arg1_id": "NCT02607319_exc_T46", "arg2_id": "NCT02607319_exc_T44", "normalized": [] }, { "id": "NCT02607319_exc_R20", "type": "Subsumes", "arg1_id": "NCT02607319_exc_T47", "arg2_id": "NCT02607319_exc_T48", "normalized": [] }, { "id": "NCT02607319_exc_R21", "type": "AND", "arg1_id": "NCT02607319_exc_T47", "arg2_id": "NCT02607319_exc_T49", "normalized": [] }, { "id": "NCT02607319_exc_R22", "type": "Has_qualifier", "arg1_id": "NCT02607319_exc_T53", "arg2_id": "NCT02607319_exc_T54", "normalized": [] }, { "id": "NCT02607319_exc_R24", "type": "Subsumes", "arg1_id": "NCT02607319_exc_T53", "arg2_id": "NCT02607319_exc_T59", "normalized": [] } ]

[ { "id": "NCT02607319_inc_text", "type": "inclusion", "text": [ "History of three or more consecutively failed In Vitro Fertilization (IVF) cycles after embryo transfer.\nNormal uterine cavity (as assessed by hysteroscopy or HSG).\nNormal hormonal investigation: TSH, PRL, FBS.\nNormal acquired/inherited thrombophilia profile: LAC, ACA IgG/IgM, Prot S, Antithrombin III, beta-2 glycoprotein, Factors V, II, MTHFR.\nNormal semen analysis and mild/moderate male factor (Total motile sperm count > 5 million/ml and/or normal WHO morphology >20%.\nPatient provides written informed consent.\n" ], "offsets": [ [ 0, 518 ] ] } ]

[ { "id": "NCT02607319_inc_T1", "type": "Multiplier", "text": [ "three or more" ], "offsets": [ [ 11, 24 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T2", "type": "Qualifier", "text": [ "consecutively", "failed" ], "offsets": [ [ 25, 38 ], [ 39, 45 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T3", "type": "Procedure", "text": [ "In Vitro Fertilization" ], "offsets": [ [ 46, 68 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T4", "type": "Procedure", "text": [ "IVF" ], "offsets": [ [ 70, 73 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T5", "type": "Temporal", "text": [ "after embryo transfer" ], "offsets": [ [ 82, 103 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T6", "type": "Reference_point", "text": [ "embryo transfer" ], "offsets": [ [ 88, 103 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T7", "type": "Observation", "text": [ "uterine cavity" ], "offsets": [ [ 112, 126 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T8", "type": "Value", "text": [ "Normal" ], "offsets": [ [ 105, 111 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T9", "type": "Procedure", "text": [ "hysteroscopy" ], "offsets": [ [ 143, 155 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T10", "type": "Procedure", "text": [ "HSG" ], "offsets": [ [ 159, 162 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T11", "type": "Scope", "text": [ "hysteroscopy or HSG" ], "offsets": [ [ 143, 162 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T12", "type": "Procedure", "text": [ "hormonal investigation:" ], "offsets": [ [ 172, 195 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T13", "type": "Value", "text": [ "Normal" ], "offsets": [ [ 165, 171 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T14", "type": "Measurement", "text": [ "TSH" ], "offsets": [ [ 196, 199 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T15", "type": "Measurement", "text": [ "PRL" ], "offsets": [ [ 201, 204 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T16", "type": "Measurement", "text": [ "FBS" ], "offsets": [ [ 206, 209 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T17", "type": "Scope", "text": [ "TSH, PRL, FBS" ], "offsets": [ [ 196, 209 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T18", "type": "Measurement", "text": [ "thrombophilia profile" ], "offsets": [ [ 237, 258 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T19", "type": "Value", "text": [ "Normal" ], "offsets": [ [ 211, 217 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T20", "type": "Measurement", "text": [ "LAC" ], "offsets": [ [ 260, 263 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T21", "type": "Measurement", "text": [ "ACA IgG" ], "offsets": [ [ 265, 272 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T22", "type": "Measurement", "text": [ "Prot S" ], "offsets": [ [ 278, 284 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T23", "type": "Measurement", "text": [ "Antithrombin III" ], "offsets": [ [ 286, 302 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T24", "type": "Measurement", "text": [ " I", ", P" ], "offsets": [ [ 268, 270 ], [ 276, 279 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T25", "type": "Measurement", "text": [ "beta-2 glycoprotein" ], "offsets": [ [ 304, 323 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T26", "type": "Measurement", "text": [ "Factors V" ], "offsets": [ [ 325, 334 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T27", "type": "Measurement", "text": [ "tors V,", " " ], "offsets": [ [ 328, 335 ], [ 339, 340 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T28", "type": "Measurement", "text": [ "MTHFR" ], "offsets": [ [ 340, 345 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T29", "type": "Scope", "text": [ "LAC, ACA IgG/IgM, Prot S, Antithrombin III, beta-2 glycoprotein, Factors V, II, MTHFR" ], "offsets": [ [ 260, 345 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T30", "type": "Measurement", "text": [ "semen analysis" ], "offsets": [ [ 354, 368 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T31", "type": "Condition", "text": [ "male factor" ], "offsets": [ [ 387, 398 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T32", "type": "Qualifier", "text": [ "moderate" ], "offsets": [ [ 378, 386 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T33", "type": "Qualifier", "text": [ "mild" ], "offsets": [ [ 373, 377 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T34", "type": "Scope", "text": [ "mild/moderate" ], "offsets": [ [ 373, 386 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T35", "type": "Measurement", "text": [ "Total motile sperm count" ], "offsets": [ [ 400, 424 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T36", "type": "Value", "text": [ "> 5 million/ml" ], "offsets": [ [ 425, 439 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T37", "type": "Measurement", "text": [ "normal WHO morphology" ], "offsets": [ [ 447, 468 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T38", "type": "Value", "text": [ ">20%" ], "offsets": [ [ 469, 473 ] ], "normalized": [] }, { "id": "NCT02607319_inc_T39", "type": "Scope", "text": [ "Total motile sperm count > 5 million/ml and/or normal WHO morphology >20%" ], "offsets": [ [ 400, 473 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02607319_inc_R1", "type": "Subsumes", "arg1_id": "NCT02607319_inc_T3", "arg2_id": "NCT02607319_inc_T4", "normalized": [] }, { "id": "NCT02607319_inc_R2", "type": "Has_index", "arg1_id": "NCT02607319_inc_T5", "arg2_id": "NCT02607319_inc_T6", "normalized": [] }, { "id": "NCT02607319_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT02607319_inc_T3", "arg2_id": "NCT02607319_inc_T2", "normalized": [] }, { "id": "NCT02607319_inc_R4", "type": "Has_multiplier", "arg1_id": "NCT02607319_inc_T3", "arg2_id": "NCT02607319_inc_T1", "normalized": [] }, { "id": "NCT02607319_inc_R5", "type": "Has_temporal", "arg1_id": "NCT02607319_inc_T3", "arg2_id": "NCT02607319_inc_T5", "normalized": [] }, { "id": "NCT02607319_inc_R6", "type": "Has_value", "arg1_id": "NCT02607319_inc_T7", "arg2_id": "NCT02607319_inc_T8", "normalized": [] }, { "id": "NCT02607319_inc_R8", "type": "Subsumes", "arg1_id": "NCT02607319_inc_T12", "arg2_id": "NCT02607319_inc_T17", "normalized": [] }, { "id": "NCT02607319_inc_R9", "type": "Has_value", "arg1_id": "NCT02607319_inc_T12", "arg2_id": "NCT02607319_inc_T13", "normalized": [] }, { "id": "NCT02607319_inc_R10", "type": "Has_value", "arg1_id": "NCT02607319_inc_T18", "arg2_id": "NCT02607319_inc_T19", "normalized": [] }, { "id": "NCT02607319_inc_R11", "type": "Subsumes", "arg1_id": "NCT02607319_inc_T18", "arg2_id": "NCT02607319_inc_T29", "normalized": [] }, { "id": "NCT02607319_inc_R12", "type": "Has_scope", "arg1_id": "NCT02607319_inc_T31", "arg2_id": "NCT02607319_inc_T34", "normalized": [] }, { "id": "NCT02607319_inc_R13", "type": "Has_value", "arg1_id": "NCT02607319_inc_T35", "arg2_id": "NCT02607319_inc_T36", "normalized": [] }, { "id": "NCT02607319_inc_R14", "type": "Has_value", "arg1_id": "NCT02607319_inc_T37", "arg2_id": "NCT02607319_inc_T38", "normalized": [] }, { "id": "NCT02607319_inc_R15", "type": "Subsumes", "arg1_id": "NCT02607319_inc_T31", "arg2_id": "NCT02607319_inc_T39", "normalized": [] } ]

[ { "id": "NCT02607748_exc_text", "type": "exclusion", "text": [ "Age < 18 years\nCreatinine > 1.5 mg/dL\nHistory of severe allergy to Iodine contrast agents\nPregnancy\nActive atrial fibrillation\nMultiple premature ventricular or atrial contractions\nEjection fraction <35%\nClass III congestive heart failure\n" ], "offsets": [ [ 0, 239 ] ] } ]

[ { "id": "NCT02607748_exc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02607748_exc_T2", "type": "Value", "text": [ "< 18 years" ], "offsets": [ [ 4, 14 ] ], "normalized": [] }, { "id": "NCT02607748_exc_T3", "type": "Measurement", "text": [ "Creatinine" ], "offsets": [ [ 15, 25 ] ], "normalized": [] }, { "id": "NCT02607748_exc_T4", "type": "Value", "text": [ "> 1.5 mg/dL" ], "offsets": [ [ 26, 37 ] ], "normalized": [] }, { "id": "NCT02607748_exc_T5", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 56, 63 ] ], "normalized": [] }, { "id": "NCT02607748_exc_T6", "type": "Procedure", "text": [ "Iodine contrast agents" ], "offsets": [ [ 67, 89 ] ], "normalized": [] }, { "id": "NCT02607748_exc_T7", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 90, 99 ] ], "normalized": [] }, { "id": "NCT02607748_exc_T8", "type": "Condition", "text": [ "atrial fibrillation" ], "offsets": [ [ 107, 126 ] ], "normalized": [] }, { "id": "NCT02607748_exc_T9", "type": "Condition", "text": [ "ple premature ventricular or a", "actions\nEjec" ], "offsets": [ [ 132, 162 ], [ 173, 185 ] ], "normalized": [] }, { "id": "NCT02607748_exc_T10", "type": "Condition", "text": [ "ple premature vent", "l contractions\nEjec" ], "offsets": [ [ 132, 150 ], [ 166, 185 ] ], "normalized": [] }, { "id": "NCT02607748_exc_T11", "type": "Measurement", "text": [ "Ejection fraction" ], "offsets": [ [ 181, 198 ] ], "normalized": [] }, { "id": "NCT02607748_exc_T12", "type": "Value", "text": [ "<35%" ], "offsets": [ [ 199, 203 ] ], "normalized": [] }, { "id": "NCT02607748_exc_T13", "type": "Condition", "text": [ "congestive heart failure" ], "offsets": [ [ 214, 238 ] ], "normalized": [] }, { "id": "NCT02607748_exc_T14", "type": "Qualifier", "text": [ "Class III" ], "offsets": [ [ 204, 213 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02607748_exc_R1", "type": "Has_value", "arg1_id": "NCT02607748_exc_T1", "arg2_id": "NCT02607748_exc_T2", "normalized": [] }, { "id": "NCT02607748_exc_R2", "type": "Has_value", "arg1_id": "NCT02607748_exc_T3", "arg2_id": "NCT02607748_exc_T4", "normalized": [] }, { "id": "NCT02607748_exc_R3", "type": "AND", "arg1_id": "NCT02607748_exc_T5", "arg2_id": "NCT02607748_exc_T6", "normalized": [] }, { "id": "NCT02607748_exc_R4", "type": "Has_value", "arg1_id": "NCT02607748_exc_T11", "arg2_id": "NCT02607748_exc_T12", "normalized": [] }, { "id": "NCT02607748_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02607748_exc_T13", "arg2_id": "NCT02607748_exc_T14", "normalized": [] } ]

[ { "id": "NCT02607748_inc_text", "type": "inclusion", "text": [ "Acute Coronary Syndrome group: 40 patients with type 1 myocardial infarction within 21 days prior to the imaging visit and invasive coronary angiography with angiographic evidence of at least a 50% stenosis in one or more coronary arteries. Only patients undergoing PCI will be included in the study.\nStable Ischemic Heart Disease group: 40 patients who have undergone invasive coronary angiography within 21 days prior to the imaging visit, with history of typical angina prior to the angiogram, but no prior myocardial infarction or coronary revascularization.\nhave no prior CAD associated event (no prior myocardial infarction, acute coronary syndrome, coronary angiogram, or PCI),\nhave CAC between 10 to <1000, and\nmatch to patients in the ACS group by gender, age by decile, and CAC category (using CAC categories of 10 to <100, 100 to <400, 400 to <1000).\n" ], "offsets": [ [ 0, 862 ] ] } ]

[ { "id": "NCT02607748_inc_T1", "type": "Condition", "text": [ "Acute Coronary Syndrome" ], "offsets": [ [ 0, 23 ] ], "normalized": [] }, { "id": "NCT02607748_inc_T4", "type": "Negation", "text": [ "no" ], "offsets": [ [ 568, 570 ] ], "normalized": [] }, { "id": "NCT02607748_inc_T5", "type": "Condition", "text": [ "CAD" ], "offsets": [ [ 577, 580 ] ], "normalized": [] }, { "id": "NCT02607748_inc_T6", "type": "Condition", "text": [ "myocardial infarction" ], "offsets": [ [ 608, 629 ] ], "normalized": [] }, { "id": "NCT02607748_inc_T7", "type": "Condition", "text": [ "acute coronary syndrome" ], "offsets": [ [ 631, 654 ] ], "normalized": [] }, { "id": "NCT02607748_inc_T8", "type": "Procedure", "text": [ "coronary angiogram" ], "offsets": [ [ 656, 674 ] ], "normalized": [] }, { "id": "NCT02607748_inc_T9", "type": "Procedure", "text": [ "PCI" ], "offsets": [ [ 679, 682 ] ], "normalized": [] }, { "id": "NCT02607748_inc_T10", "type": "Scope", "text": [ "myocardial infarction, acute coronary syndrome, coronary angiogram, or PCI" ], "offsets": [ [ 608, 682 ] ], "normalized": [] }, { "id": "NCT02607748_inc_T11", "type": "Measurement", "text": [ "CAC" ], "offsets": [ [ 690, 693 ] ], "normalized": [] }, { "id": "NCT02607748_inc_T12", "type": "Value", "text": [ "between 10 to <1000" ], "offsets": [ [ 694, 713 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02607748_inc_R1", "type": "Has_negation", "arg1_id": "NCT02607748_inc_T5", "arg2_id": "NCT02607748_inc_T4", "normalized": [] }, { "id": "NCT02607748_inc_R2", "type": "Subsumes", "arg1_id": "NCT02607748_inc_T5", "arg2_id": "NCT02607748_inc_T10", "normalized": [] }, { "id": "NCT02607748_inc_R3", "type": "Has_value", "arg1_id": "NCT02607748_inc_T11", "arg2_id": "NCT02607748_inc_T12", "normalized": [] } ]

[ { "id": "NCT02609048_exc_text", "type": "exclusion", "text": [ "1. A medical condition, other than PBC, that in the investigator's opinion would preclude full participation in the study or confound its results (e.g., cancer on active treatment) \n2. AST or ALT > 3 × ULN \n3. Total bilirubin > 2 × ULN \n4. Auto-immune hepatitis \n5. Primary sclerosing cholangitis \n6. Known history of alpha-1-Antitrypsin deficiency \n7. Known history of chronic viral hepatitis \n8. Creatine kinase above ULN \n9. Serum creatinine above ULN \n10. For females, pregnancy or breast-feeding \n11. Use of colchicine, methotrexate, azathioprine, or systemic steroids in the two months preceding screening \n12. Current use of fibrates, including fenofibrates, or simvastatin \n13. Use of an experimental treatment for PBC \n14. Use of experimental or unapproved immunosuppressant \n15. Any other condition(s) that would compromise the safety of the subject or compromise the quality of the clinical study, as judged by the Investigator \n \n" ], "offsets": [ [ 0, 951 ] ] } ]

[ { "id": "NCT02609048_exc_T16", "type": "Condition", "text": [ "medical condition" ], "offsets": [ [ 5, 22 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T17", "type": "Condition", "text": [ "PBC" ], "offsets": [ [ 35, 38 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T18", "type": "Negation", "text": [ "other than" ], "offsets": [ [ 24, 34 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T22", "type": "Measurement", "text": [ "AST" ], "offsets": [ [ 185, 188 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T23", "type": "Measurement", "text": [ "ALT" ], "offsets": [ [ 192, 195 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T24", "type": "Value", "text": [ "> 3 × ULN" ], "offsets": [ [ 196, 205 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T25", "type": "Measurement", "text": [ "Total bilirubin" ], "offsets": [ [ 210, 225 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T26", "type": "Value", "text": [ "> 2 × ULN" ], "offsets": [ [ 226, 235 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T27", "type": "Condition", "text": [ "Auto-immune hepatitis" ], "offsets": [ [ 240, 261 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T28", "type": "Condition", "text": [ "Primary sclerosing cholangitis" ], "offsets": [ [ 266, 296 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T29", "type": "Condition", "text": [ "alpha-1-Antitrypsin deficiency" ], "offsets": [ [ 318, 348 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T30", "type": "Observation", "text": [ "history" ], "offsets": [ [ 307, 314 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T31", "type": "Condition", "text": [ "viral hepatitis" ], "offsets": [ [ 378, 393 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T32", "type": "Temporal", "text": [ "chronic" ], "offsets": [ [ 370, 377 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T33", "type": "Observation", "text": [ "history" ], "offsets": [ [ 359, 366 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T34", "type": "Measurement", "text": [ "Creatine kinase" ], "offsets": [ [ 398, 413 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T35", "type": "Value", "text": [ "above ULN" ], "offsets": [ [ 414, 423 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T36", "type": "Measurement", "text": [ "Serum creatinine" ], "offsets": [ [ 428, 444 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T37", "type": "Value", "text": [ "above ULN" ], "offsets": [ [ 445, 454 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T38", "type": "Person", "text": [ "females" ], "offsets": [ [ 464, 471 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T39", "type": "Condition", "text": [ "pregnancy" ], "offsets": [ [ 473, 482 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T40", "type": "Condition", "text": [ "breast-feeding" ], "offsets": [ [ 486, 500 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T41", "type": "Scope", "text": [ "pregnancy or breast-feeding" ], "offsets": [ [ 473, 500 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T42", "type": "Drug", "text": [ "colchicine" ], "offsets": [ [ 513, 523 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T43", "type": "Drug", "text": [ "methotrexate" ], "offsets": [ [ 525, 537 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T44", "type": "Drug", "text": [ "azathioprine" ], "offsets": [ [ 539, 551 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T45", "type": "Drug", "text": [ "systemic steroids" ], "offsets": [ [ 556, 573 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T46", "type": "Temporal", "text": [ "in the two months preceding screening" ], "offsets": [ [ 574, 611 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T47", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 602, 611 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T48", "type": "Scope", "text": [ "colchicine, methotrexate, azathioprine, or systemic steroids" ], "offsets": [ [ 513, 573 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T49", "type": "Drug", "text": [ "fibrates" ], "offsets": [ [ 632, 640 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T50", "type": "Temporal", "text": [ "Current" ], "offsets": [ [ 617, 624 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T51", "type": "Drug", "text": [ "fenofibrates" ], "offsets": [ [ 652, 664 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T52", "type": "Drug", "text": [ "simvastatin" ], "offsets": [ [ 669, 680 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T53", "type": "Scope", "text": [ "fibrates, including fenofibrates, or simvastatin" ], "offsets": [ [ 632, 680 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T55", "type": "Procedure", "text": [ "experimental treatment for PBC" ], "offsets": [ [ 696, 726 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T57", "type": "Drug", "text": [ "immunosuppressant" ], "offsets": [ [ 766, 783 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T58", "type": "Qualifier", "text": [ "unapproved" ], "offsets": [ [ 755, 765 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T59", "type": "Qualifier", "text": [ "experimental" ], "offsets": [ [ 739, 751 ] ], "normalized": [] }, { "id": "NCT02609048_exc_T60", "type": "Scope", "text": [ "experimental or unapproved" ], "offsets": [ [ 739, 765 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02609048_exc_R1", "type": "AND", "arg1_id": "NCT02609048_exc_T16", "arg2_id": "NCT02609048_exc_T17", "normalized": [] }, { "id": "NCT02609048_exc_R2", "type": "Has_value", "arg1_id": "NCT02609048_exc_T23", "arg2_id": "NCT02609048_exc_T24", "normalized": [] }, { "id": "NCT02609048_exc_R3", "type": "Has_value", "arg1_id": "NCT02609048_exc_T22", "arg2_id": "NCT02609048_exc_T24", "normalized": [] }, { "id": "NCT02609048_exc_R4", "type": "Has_value", "arg1_id": "NCT02609048_exc_T25", "arg2_id": "NCT02609048_exc_T26", "normalized": [] }, { "id": "NCT02609048_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02609048_exc_T29", "arg2_id": "NCT02609048_exc_T30", "normalized": [] }, { "id": "NCT02609048_exc_R6", "type": "Has_temporal", "arg1_id": "NCT02609048_exc_T31", "arg2_id": "NCT02609048_exc_T32", "normalized": [] }, { "id": "NCT02609048_exc_R7", "type": "Has_temporal", "arg1_id": "NCT02609048_exc_T31", "arg2_id": "NCT02609048_exc_T33", "normalized": [] }, { "id": "NCT02609048_exc_R8", "type": "Has_value", "arg1_id": "NCT02609048_exc_T34", "arg2_id": "NCT02609048_exc_T35", "normalized": [] }, { "id": "NCT02609048_exc_R9", "type": "Has_value", "arg1_id": "NCT02609048_exc_T36", "arg2_id": "NCT02609048_exc_T37", "normalized": [] }, { "id": "NCT02609048_exc_R10", "type": "Has_scope", "arg1_id": "NCT02609048_exc_T38", "arg2_id": "NCT02609048_exc_T41", "normalized": [] }, { "id": "NCT02609048_exc_R11", "type": "Has_index", "arg1_id": "NCT02609048_exc_T46", "arg2_id": "NCT02609048_exc_T47", "normalized": [] }, { "id": "NCT02609048_exc_R12", "type": "Has_temporal", "arg1_id": "NCT02609048_exc_T48", "arg2_id": "NCT02609048_exc_T46", "normalized": [] }, { "id": "NCT02609048_exc_R13", "type": "Has_temporal", "arg1_id": "NCT02609048_exc_T53", "arg2_id": "NCT02609048_exc_T50", "normalized": [] }, { "id": "NCT02609048_exc_R14", "type": "Has_scope", "arg1_id": "NCT02609048_exc_T57", "arg2_id": "NCT02609048_exc_T60", "normalized": [] } ]

[ { "id": "NCT02609048_inc_text", "type": "inclusion", "text": [ "1. Must have given written informed consent (signed and dated) and any authorizations required by local law \n2. 18 to 75 years old (inclusive) \n3. Male or female with a diagnosis of PBC, by at least two of the following criteria: \nHistory of AP above ULN for at least six months \nPositive Anti-Mitochondrial Antibodies (AMA) titers (>1/40 on immunofluorescence or M2 positive by enzyme linked immunosorbent assay (ELISA) or positive PBC-specific antinuclear antibodies \nDocumented liver biopsy result consistent with PBC \n4. On a stable and recommended dose of UDCA for the past twelve months \n5. AP ≥ 1.67 × ULN \n6. For females of reproductive potential, use of at least one barrier contraceptive and a second effective birth control method during the study and for at least two weeks after the last dose. For male subjects, use of appropriate contraception (e.g., condoms), so their female partners of reproductive potential do not become pregnant during the study and for at least two weeks after the last dose \n" ], "offsets": [ [ 0, 1015 ] ] } ]

[ { "id": "NCT02609048_inc_T8", "type": "Value", "text": [ "18 to 75 years old (inclusive)" ], "offsets": [ [ 112, 142 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T9", "type": "Person", "text": [ "years old" ], "offsets": [ [ 121, 130 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T10", "type": "Person", "text": [ "Male" ], "offsets": [ [ 147, 151 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T11", "type": "Person", "text": [ "female" ], "offsets": [ [ 155, 161 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T12", "type": "Condition", "text": [ "PBC" ], "offsets": [ [ 182, 185 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T13", "type": "Multiplier", "text": [ "at least two" ], "offsets": [ [ 190, 202 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T15", "type": "Measurement", "text": [ "following criteria" ], "offsets": [ [ 210, 228 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T16", "type": "Measurement", "text": [ "Positive Anti-Mitochondrial Antibodies (AMA) titers" ], "offsets": [ [ 280, 331 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T17", "type": "Value", "text": [ ">1/40" ], "offsets": [ [ 333, 338 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T18", "type": "Measurement", "text": [ "immunofluorescence" ], "offsets": [ [ 342, 360 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T19", "type": "Value", "text": [ "M2 positive" ], "offsets": [ [ 364, 375 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T20", "type": "Measurement", "text": [ "enzyme linked immunosorbent assay (ELISA)" ], "offsets": [ [ 379, 420 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T21", "type": "Measurement", "text": [ "PBC-specific antinuclear antibodies" ], "offsets": [ [ 433, 468 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T22", "type": "Value", "text": [ "positive" ], "offsets": [ [ 424, 432 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T23", "type": "Scope", "text": [ ">1/40 on immunofluorescence or M2 positive by enzyme linked immunosorbent assay (ELISA) or positive PBC-specific antinuclear antibodies" ], "offsets": [ [ 333, 468 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T24", "type": "Measurement", "text": [ "AP" ], "offsets": [ [ 242, 244 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T25", "type": "Value", "text": [ "above ULN" ], "offsets": [ [ 245, 254 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T26", "type": "Temporal", "text": [ "for at least six months" ], "offsets": [ [ 255, 278 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T27", "type": "Procedure", "text": [ "liver biopsy" ], "offsets": [ [ 481, 493 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T28", "type": "Condition", "text": [ "PBC" ], "offsets": [ [ 517, 520 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T29", "type": "Qualifier", "text": [ "stable", "dose" ], "offsets": [ [ 530, 536 ], [ 553, 557 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T30", "type": "Qualifier", "text": [ "recommended dose" ], "offsets": [ [ 541, 557 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T31", "type": "Drug", "text": [ "UDCA" ], "offsets": [ [ 561, 565 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T32", "type": "Temporal", "text": [ "for the past twelve months" ], "offsets": [ [ 566, 592 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T33", "type": "Measurement", "text": [ "AP" ], "offsets": [ [ 597, 599 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T34", "type": "Value", "text": [ "≥ 1.67 × ULN" ], "offsets": [ [ 600, 612 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T35", "type": "Condition", "text": [ "reproductive potential" ], "offsets": [ [ 632, 654 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T36", "type": "Person", "text": [ "females" ], "offsets": [ [ 621, 628 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T37", "type": "Multiplier", "text": [ "at least one" ], "offsets": [ [ 663, 675 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T38", "type": "Device", "text": [ "barrier contraceptive" ], "offsets": [ [ 676, 697 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T39", "type": "Qualifier", "text": [ "second" ], "offsets": [ [ 704, 710 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T40", "type": "Device", "text": [ "birth control method" ], "offsets": [ [ 721, 741 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T41", "type": "Qualifier", "text": [ "effective" ], "offsets": [ [ 711, 720 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T43", "type": "Temporal", "text": [ "during the study" ], "offsets": [ [ 742, 758 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T44", "type": "Temporal", "text": [ "for at least two weeks after the last dose" ], "offsets": [ [ 763, 805 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T45", "type": "Reference_point", "text": [ "the last dose" ], "offsets": [ [ 792, 805 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T46", "type": "Scope", "text": [ "females of reproductive potential" ], "offsets": [ [ 621, 654 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T47", "type": "Scope", "text": [ "at least one barrier contraceptive and a second effective birth control method during the study and for at least two weeks after the last dose" ], "offsets": [ [ 663, 805 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T48", "type": "Person", "text": [ "male" ], "offsets": [ [ 811, 815 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T49", "type": "Device", "text": [ "contraception" ], "offsets": [ [ 845, 858 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T50", "type": "Device", "text": [ "condoms" ], "offsets": [ [ 866, 873 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T51", "type": "Qualifier", "text": [ "appropriate" ], "offsets": [ [ 833, 844 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T53", "type": "Person", "text": [ "female" ], "offsets": [ [ 885, 891 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T54", "type": "Condition", "text": [ "reproductive potential" ], "offsets": [ [ 904, 926 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T55", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 941, 949 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T56", "type": "Negation", "text": [ "not become" ], "offsets": [ [ 930, 940 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T57", "type": "Temporal", "text": [ "during the study" ], "offsets": [ [ 950, 966 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T58", "type": "Temporal", "text": [ "for at least two weeks after the last dose" ], "offsets": [ [ 971, 1013 ] ], "normalized": [] }, { "id": "NCT02609048_inc_T59", "type": "Reference_point", "text": [ "the last dose" ], "offsets": [ [ 1000, 1013 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02609048_inc_R1", "type": "Has_multiplier", "arg1_id": "NCT02609048_inc_T15", "arg2_id": "NCT02609048_inc_T13", "normalized": [] }, { "id": "NCT02609048_inc_R2", "type": "Has_value", "arg1_id": "NCT02609048_inc_T20", "arg2_id": "NCT02609048_inc_T19", "normalized": [] }, { "id": "NCT02609048_inc_R3", "type": "Has_value", "arg1_id": "NCT02609048_inc_T18", "arg2_id": "NCT02609048_inc_T17", "normalized": [] }, { "id": "NCT02609048_inc_R4", "type": "Has_value", "arg1_id": "NCT02609048_inc_T21", "arg2_id": "NCT02609048_inc_T22", "normalized": [] }, { "id": "NCT02609048_inc_R5", "type": "Subsumes", "arg1_id": "NCT02609048_inc_T16", "arg2_id": "NCT02609048_inc_T23", "normalized": [] }, { "id": "NCT02609048_inc_R6", "type": "Has_value", "arg1_id": "NCT02609048_inc_T24", "arg2_id": "NCT02609048_inc_T25", "normalized": [] }, { "id": "NCT02609048_inc_R7", "type": "Has_temporal", "arg1_id": "NCT02609048_inc_T24", "arg2_id": "NCT02609048_inc_T26", "normalized": [] }, { "id": "NCT02609048_inc_R8", "type": "AND", "arg1_id": "NCT02609048_inc_T27", "arg2_id": "NCT02609048_inc_T28", "normalized": [] }, { "id": "NCT02609048_inc_R9", "type": "Has_temporal", "arg1_id": "NCT02609048_inc_T31", "arg2_id": "NCT02609048_inc_T32", "normalized": [] }, { "id": "NCT02609048_inc_R10", "type": "Has_qualifier", "arg1_id": "NCT02609048_inc_T31", "arg2_id": "NCT02609048_inc_T29", "normalized": [] }, { "id": "NCT02609048_inc_R11", "type": "Has_qualifier", "arg1_id": "NCT02609048_inc_T31", "arg2_id": "NCT02609048_inc_T30", "normalized": [] }, { "id": "NCT02609048_inc_R12", "type": "Has_value", "arg1_id": "NCT02609048_inc_T33", "arg2_id": "NCT02609048_inc_T34", "normalized": [] }, { "id": "NCT02609048_inc_R13", "type": "Has_multiplier", "arg1_id": "NCT02609048_inc_T38", "arg2_id": "NCT02609048_inc_T37", "normalized": [] }, { "id": "NCT02609048_inc_R14", "type": "Has_qualifier", "arg1_id": "NCT02609048_inc_T40", "arg2_id": "NCT02609048_inc_T39", "normalized": [] }, { "id": "NCT02609048_inc_R15", "type": "Has_qualifier", "arg1_id": "NCT02609048_inc_T40", "arg2_id": "NCT02609048_inc_T41", "normalized": [] }, { "id": "NCT02609048_inc_R16", "type": "Has_index", "arg1_id": "NCT02609048_inc_T44", "arg2_id": "NCT02609048_inc_T45", "normalized": [] }, { "id": "NCT02609048_inc_R17", "type": "Has_temporal", "arg1_id": "NCT02609048_inc_T40", "arg2_id": "NCT02609048_inc_T43", "normalized": [] }, { "id": "NCT02609048_inc_R18", "type": "Has_temporal", "arg1_id": "NCT02609048_inc_T40", "arg2_id": "NCT02609048_inc_T44", "normalized": [] }, { "id": "NCT02609048_inc_R19", "type": "Has_scope", "arg1_id": "NCT02609048_inc_T46", "arg2_id": "NCT02609048_inc_T47", "normalized": [] }, { "id": "NCT02609048_inc_R20", "type": "Subsumes", "arg1_id": "NCT02609048_inc_T49", "arg2_id": "NCT02609048_inc_T50", "normalized": [] }, { "id": "NCT02609048_inc_R21", "type": "Has_qualifier", "arg1_id": "NCT02609048_inc_T49", "arg2_id": "NCT02609048_inc_T51", "normalized": [] }, { "id": "NCT02609048_inc_R22", "type": "Has_negation", "arg1_id": "NCT02609048_inc_T55", "arg2_id": "NCT02609048_inc_T56", "normalized": [] }, { "id": "NCT02609048_inc_R23", "type": "Has_index", "arg1_id": "NCT02609048_inc_T58", "arg2_id": "NCT02609048_inc_T59", "normalized": [] }, { "id": "NCT02609048_inc_R24", "type": "Has_temporal", "arg1_id": "NCT02609048_inc_T55", "arg2_id": "NCT02609048_inc_T57", "normalized": [] }, { "id": "NCT02609048_inc_R25", "type": "Has_temporal", "arg1_id": "NCT02609048_inc_T55", "arg2_id": "NCT02609048_inc_T58", "normalized": [] }, { "id": "NCT02609048_inc_R26", "type": "AND", "arg1_id": "NCT02609048_inc_T53", "arg2_id": "NCT02609048_inc_T54", "normalized": [] }, { "id": "NCT02609048_inc_R27", "type": "AND", "arg1_id": "NCT02609048_inc_T53", "arg2_id": "NCT02609048_inc_T55", "normalized": [] } ]

[ { "id": "NCT02609425_exc_text", "type": "exclusion", "text": [ "Any patient with esophageal cancer who is not deemed a surgical candidate or who is not deemed a candidate for the Ivor Lewis technique of esophagectomy (with intrathoracic anastomosis).\nAny patient less than 18 years of age\n" ], "offsets": [ [ 0, 225 ] ] } ]

[ { "id": "NCT02609425_exc_T1", "type": "Condition", "text": [ "esophageal cancer" ], "offsets": [ [ 17, 34 ] ], "normalized": [] }, { "id": "NCT02609425_exc_T2", "type": "Negation", "text": [ "not" ], "offsets": [ [ 42, 45 ] ], "normalized": [] }, { "id": "NCT02609425_exc_T3", "type": "Observation", "text": [ "candidate" ], "offsets": [ [ 64, 73 ] ], "normalized": [] }, { "id": "NCT02609425_exc_T4", "type": "Negation", "text": [ "not" ], "offsets": [ [ 84, 87 ] ], "normalized": [] }, { "id": "NCT02609425_exc_T5", "type": "Observation", "text": [ "candidate" ], "offsets": [ [ 97, 106 ] ], "normalized": [] }, { "id": "NCT02609425_exc_T6", "type": "Procedure", "text": [ "surgical" ], "offsets": [ [ 55, 63 ] ], "normalized": [] }, { "id": "NCT02609425_exc_T7", "type": "Qualifier", "text": [ "Ivor Lewis technique" ], "offsets": [ [ 115, 135 ] ], "normalized": [] }, { "id": "NCT02609425_exc_T8", "type": "Procedure", "text": [ "esophagectomy" ], "offsets": [ [ 139, 152 ] ], "normalized": [] }, { "id": "NCT02609425_exc_T9", "type": "Condition", "text": [ "intrathoracic anastomosis" ], "offsets": [ [ 159, 184 ] ], "normalized": [] }, { "id": "NCT02609425_exc_T10", "type": "Qualifier", "text": [ "with intrathoracic anastomosis" ], "offsets": [ [ 154, 184 ] ], "normalized": [] }, { "id": "NCT02609425_exc_T11", "type": "Value", "text": [ "less than 18 years" ], "offsets": [ [ 199, 217 ] ], "normalized": [] }, { "id": "NCT02609425_exc_T12", "type": "Person", "text": [ "age" ], "offsets": [ [ 221, 224 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02609425_exc_R1", "type": "Has_negation", "arg1_id": "NCT02609425_exc_T3", "arg2_id": "NCT02609425_exc_T2", "normalized": [] }, { "id": "NCT02609425_exc_R2", "type": "AND", "arg1_id": "NCT02609425_exc_T3", "arg2_id": "NCT02609425_exc_T6", "normalized": [] }, { "id": "NCT02609425_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02609425_exc_T8", "arg2_id": "NCT02609425_exc_T7", "normalized": [] }, { "id": "NCT02609425_exc_R4", "type": "AND", "arg1_id": "NCT02609425_exc_T5", "arg2_id": "NCT02609425_exc_T8", "normalized": [] }, { "id": "NCT02609425_exc_R5", "type": "Has_negation", "arg1_id": "NCT02609425_exc_T5", "arg2_id": "NCT02609425_exc_T4", "normalized": [] }, { "id": "NCT02609425_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT02609425_exc_T8", "arg2_id": "NCT02609425_exc_T10", "normalized": [] }, { "id": "NCT02609425_exc_R8", "type": "Has_value", "arg1_id": "NCT02609425_exc_T12", "arg2_id": "NCT02609425_exc_T11", "normalized": [] } ]

[ { "id": "NCT02609425_inc_text", "type": "inclusion", "text": [ "All patients with esophageal cancer who are deemed candidates for minimally invasive robot assisted Ivor Lewis esophagogastrectomy.\nPatients who provide written informed consent for the study.\n" ], "offsets": [ [ 0, 193 ] ] } ]

[ { "id": "NCT02609425_inc_T1", "type": "Condition", "text": [ "esophageal cancer" ], "offsets": [ [ 18, 35 ] ], "normalized": [] }, { "id": "NCT02609425_inc_T2", "type": "Observation", "text": [ "candidates" ], "offsets": [ [ 51, 61 ] ], "normalized": [] }, { "id": "NCT02609425_inc_T3", "type": "Qualifier", "text": [ "minimally invasive" ], "offsets": [ [ 66, 84 ] ], "normalized": [] }, { "id": "NCT02609425_inc_T4", "type": "Qualifier", "text": [ "robot assisted" ], "offsets": [ [ 85, 99 ] ], "normalized": [] }, { "id": "NCT02609425_inc_T5", "type": "Qualifier", "text": [ "Ivor Lewis" ], "offsets": [ [ 100, 110 ] ], "normalized": [] }, { "id": "NCT02609425_inc_T6", "type": "Procedure", "text": [ "esophagogastrectomy" ], "offsets": [ [ 111, 130 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02609425_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT02609425_inc_T6", "arg2_id": "NCT02609425_inc_T5", "normalized": [] }, { "id": "NCT02609425_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02609425_inc_T6", "arg2_id": "NCT02609425_inc_T4", "normalized": [] }, { "id": "NCT02609425_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT02609425_inc_T6", "arg2_id": "NCT02609425_inc_T3", "normalized": [] }, { "id": "NCT02609425_inc_R4", "type": "AND", "arg1_id": "NCT02609425_inc_T2", "arg2_id": "NCT02609425_inc_T6", "normalized": [] } ]

[ { "id": "NCT02609698_exc_text", "type": "exclusion", "text": [ "Patients with any contraindications or hypersensitivity related to antiplatelet therapy\nPatients with Acute Myocardial Infarction (ST elevation myocardial infarction, Non ST elevation myocardial infarction)\nPatients who are anticipated to receive treatment or surgery that may require desisting the administration of antiplatelet therapy for 2 weeks or longer during the period of the clinical trial\nChronic total occlusion (CTO) lesions, in-stent restenosis (ISR)\nPatients experiencing cardiogenic shock\nWomen who are breastfeeding, pregnant, or desiring pregnancy\nPatients with findings of hemorrhage\nPatients with a life expectancy of less than 1 year\nPatients who have received a drug-eluting stent (DES) procedure within the past 6 months\nAny other patients judged by the investigator to be unsuitable for the trial\n" ], "offsets": [ [ 0, 821 ] ] } ]

[ { "id": "NCT02609698_exc_T1", "type": "Condition", "text": [ "contraindications" ], "offsets": [ [ 18, 35 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T2", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 39, 55 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T3", "type": "Procedure", "text": [ "antiplatelet therapy" ], "offsets": [ [ 67, 87 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T4", "type": "Scope", "text": [ "contraindications or hypersensitivity" ], "offsets": [ [ 18, 55 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T5", "type": "Condition", "text": [ "Acute Myocardial Infarction" ], "offsets": [ [ 102, 129 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T6", "type": "Condition", "text": [ "ST elevation myocardial infarction" ], "offsets": [ [ 131, 165 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T7", "type": "Condition", "text": [ "Non ST elevation myocardial infarction" ], "offsets": [ [ 167, 205 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T8", "type": "Scope", "text": [ "ST elevation myocardial infarction, Non ST elevation myocardial infarction" ], "offsets": [ [ 131, 205 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T9", "type": "Mood", "text": [ "anticipated to" ], "offsets": [ [ 224, 238 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T10", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 247, 256 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T11", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 260, 267 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T12", "type": "Procedure", "text": [ "antiplatelet therapy" ], "offsets": [ [ 317, 337 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T13", "type": "Temporal", "text": [ "for 2 weeks or longer" ], "offsets": [ [ 338, 359 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T14", "type": "Scope", "text": [ "treatment or surgery" ], "offsets": [ [ 247, 267 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T15", "type": "Condition", "text": [ "Chronic total occlusion" ], "offsets": [ [ 400, 423 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T16", "type": "Condition", "text": [ "CTO" ], "offsets": [ [ 425, 428 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T17", "type": "Condition", "text": [ "in-stent restenosis" ], "offsets": [ [ 439, 458 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T18", "type": "Condition", "text": [ "ISR" ], "offsets": [ [ 460, 463 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T19", "type": "Condition", "text": [ "cardiogenic shock" ], "offsets": [ [ 487, 504 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T21", "type": "Condition", "text": [ "hemorrhage" ], "offsets": [ [ 592, 602 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T22", "type": "Observation", "text": [ "life expectancy" ], "offsets": [ [ 619, 634 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T23", "type": "Value", "text": [ "less than 1 year" ], "offsets": [ [ 638, 654 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T24", "type": "Procedure", "text": [ "ting stent (DES) p", "e within" ], "offsets": [ [ 692, 710 ], [ 717, 725 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T25", "type": "Procedure", "text": [ "DES" ], "offsets": [ [ 704, 707 ] ], "normalized": [] }, { "id": "NCT02609698_exc_T26", "type": "Temporal", "text": [ "past 6 months" ], "offsets": [ [ 730, 743 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02609698_exc_R1", "type": "AND", "arg1_id": "NCT02609698_exc_T4", "arg2_id": "NCT02609698_exc_T3", "normalized": [] }, { "id": "NCT02609698_exc_R2", "type": "Subsumes", "arg1_id": "NCT02609698_exc_T5", "arg2_id": "NCT02609698_exc_T8", "normalized": [] }, { "id": "NCT02609698_exc_R3", "type": "Has_mood", "arg1_id": "NCT02609698_exc_T14", "arg2_id": "NCT02609698_exc_T9", "normalized": [] }, { "id": "NCT02609698_exc_R4", "type": "AND", "arg1_id": "NCT02609698_exc_T14", "arg2_id": "NCT02609698_exc_T12", "normalized": [] }, { "id": "NCT02609698_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02609698_exc_T12", "arg2_id": "NCT02609698_exc_T13", "normalized": [] }, { "id": "NCT02609698_exc_R6", "type": "Subsumes", "arg1_id": "NCT02609698_exc_T15", "arg2_id": "NCT02609698_exc_T16", "normalized": [] }, { "id": "NCT02609698_exc_R7", "type": "Subsumes", "arg1_id": "NCT02609698_exc_T17", "arg2_id": "NCT02609698_exc_T18", "normalized": [] }, { "id": "NCT02609698_exc_R8", "type": "Has_value", "arg1_id": "NCT02609698_exc_T22", "arg2_id": "NCT02609698_exc_T23", "normalized": [] }, { "id": "NCT02609698_exc_R9", "type": "Subsumes", "arg1_id": "NCT02609698_exc_T24", "arg2_id": "NCT02609698_exc_T25", "normalized": [] }, { "id": "NCT02609698_exc_R10", "type": "Has_temporal", "arg1_id": "NCT02609698_exc_T24", "arg2_id": "NCT02609698_exc_T26", "normalized": [] } ]

[ { "id": "NCT02609698_inc_text", "type": "inclusion", "text": [ "Patients aged 19 or older\nPatients who have submitted a written consent to participate in the clinical trial\nDe novo lesion\nPatients scheduled for elective intervention to treat ischemic cardiovascular disease\n" ], "offsets": [ [ 0, 210 ] ] } ]

[ { "id": "NCT02609698_inc_T1", "type": "Person", "text": [ "aged" ], "offsets": [ [ 9, 13 ] ], "normalized": [] }, { "id": "NCT02609698_inc_T2", "type": "Value", "text": [ "19 or older" ], "offsets": [ [ 14, 25 ] ], "normalized": [] }, { "id": "NCT02609698_inc_T4", "type": "Condition", "text": [ "De novo lesion" ], "offsets": [ [ 109, 123 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02609698_inc_R1", "type": "Has_value", "arg1_id": "NCT02609698_inc_T1", "arg2_id": "NCT02609698_inc_T2", "normalized": [] } ]

[ { "id": "NCT02612181_exc_text", "type": "exclusion", "text": [ "Age< 18\nPregnancy\nBradycardia (HR<55bpm)\nSystolic Blood Pressure < 80 mmHg / Mean arterial pressure < 50 mmHg on maximal support\nDeath imminent\nUnlikely to survive 90 days\nAcute liver failure\nDementia\nHigh-grade block in the absence of a functioning pacemaker.\n" ], "offsets": [ [ 0, 261 ] ] } ]

[ { "id": "NCT02612181_exc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02612181_exc_T2", "type": "Value", "text": [ "< 18" ], "offsets": [ [ 3, 7 ] ], "normalized": [] }, { "id": "NCT02612181_exc_T3", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 8, 17 ] ], "normalized": [] }, { "id": "NCT02612181_exc_T4", "type": "Condition", "text": [ "Bradycardia" ], "offsets": [ [ 18, 29 ] ], "normalized": [] }, { "id": "NCT02612181_exc_T5", "type": "Measurement", "text": [ "HR" ], "offsets": [ [ 31, 33 ] ], "normalized": [] }, { "id": "NCT02612181_exc_T6", "type": "Value", "text": [ "<55bpm" ], "offsets": [ [ 33, 39 ] ], "normalized": [] }, { "id": "NCT02612181_exc_T7", "type": "Measurement", "text": [ "Systolic Blood Pressure" ], "offsets": [ [ 41, 64 ] ], "normalized": [] }, { "id": "NCT02612181_exc_T8", "type": "Value", "text": [ "< 80 mmHg" ], "offsets": [ [ 65, 74 ] ], "normalized": [] }, { "id": "NCT02612181_exc_T9", "type": "Measurement", "text": [ "Mean arterial pressure" ], "offsets": [ [ 77, 99 ] ], "normalized": [] }, { "id": "NCT02612181_exc_T10", "type": "Value", "text": [ "< 50 mmHg" ], "offsets": [ [ 100, 109 ] ], "normalized": [] }, { "id": "NCT02612181_exc_T11", "type": "Qualifier", "text": [ "on maximal support" ], "offsets": [ [ 110, 128 ] ], "normalized": [] }, { "id": "NCT02612181_exc_T12", "type": "Scope", "text": [ "Systolic Blood Pressure < 80 mmHg / Mean arterial pressure < 50 mmHg" ], "offsets": [ [ 41, 109 ] ], "normalized": [] }, { "id": "NCT02612181_exc_T13", "type": "Procedure", "text": [ "support" ], "offsets": [ [ 121, 128 ] ], "normalized": [] }, { "id": "NCT02612181_exc_T14", "type": "Condition", "text": [ "Death" ], "offsets": [ [ 129, 134 ] ], "normalized": [] }, { "id": "NCT02612181_exc_T15", "type": "Temporal", "text": [ "imminent" ], "offsets": [ [ 135, 143 ] ], "normalized": [] }, { "id": "NCT02612181_exc_T17", "type": "Condition", "text": [ "Acute liver failure" ], "offsets": [ [ 172, 191 ] ], "normalized": [] }, { "id": "NCT02612181_exc_T18", "type": "Condition", "text": [ "Dementia" ], "offsets": [ [ 192, 200 ] ], "normalized": [] }, { "id": "NCT02612181_exc_T19", "type": "Condition", "text": [ "High-grade block" ], "offsets": [ [ 201, 217 ] ], "normalized": [] }, { "id": "NCT02612181_exc_T20", "type": "Negation", "text": [ "in the absence of" ], "offsets": [ [ 218, 235 ] ], "normalized": [] }, { "id": "NCT02612181_exc_T21", "type": "Device", "text": [ "pacemaker" ], "offsets": [ [ 250, 259 ] ], "normalized": [] }, { "id": "NCT02612181_exc_T22", "type": "Qualifier", "text": [ "functioning" ], "offsets": [ [ 238, 249 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02612181_exc_R1", "type": "Has_value", "arg1_id": "NCT02612181_exc_T1", "arg2_id": "NCT02612181_exc_T2", "normalized": [] }, { "id": "NCT02612181_exc_R2", "type": "Has_value", "arg1_id": "NCT02612181_exc_T5", "arg2_id": "NCT02612181_exc_T6", "normalized": [] }, { "id": "NCT02612181_exc_R3", "type": "Subsumes", "arg1_id": "NCT02612181_exc_T4", "arg2_id": "NCT02612181_exc_T5", "normalized": [] }, { "id": "NCT02612181_exc_R4", "type": "Has_value", "arg1_id": "NCT02612181_exc_T7", "arg2_id": "NCT02612181_exc_T8", "normalized": [] }, { "id": "NCT02612181_exc_R5", "type": "Has_value", "arg1_id": "NCT02612181_exc_T9", "arg2_id": "NCT02612181_exc_T10", "normalized": [] }, { "id": "NCT02612181_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02612181_exc_T12", "arg2_id": "NCT02612181_exc_T11", "normalized": [] }, { "id": "NCT02612181_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02612181_exc_T14", "arg2_id": "NCT02612181_exc_T15", "normalized": [] }, { "id": "NCT02612181_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT02612181_exc_T21", "arg2_id": "NCT02612181_exc_T22", "normalized": [] }, { "id": "NCT02612181_exc_R10", "type": "Has_negation", "arg1_id": "NCT02612181_exc_T21", "arg2_id": "NCT02612181_exc_T20", "normalized": [] }, { "id": "NCT02612181_exc_R11", "type": "AND", "arg1_id": "NCT02612181_exc_T19", "arg2_id": "NCT02612181_exc_T21", "normalized": [] } ]

[ { "id": "NCT02612181_inc_text", "type": "inclusion", "text": [ "Septic shock patients despite early goal directed therapy\nAgree to participate this study\n" ], "offsets": [ [ 0, 90 ] ] } ]

[ { "id": "NCT02612181_inc_T1", "type": "Condition", "text": [ "Septic shock" ], "offsets": [ [ 0, 12 ] ], "normalized": [] }, { "id": "NCT02612181_inc_T2", "type": "Procedure", "text": [ "early goal directed therapy" ], "offsets": [ [ 30, 57 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02612181_inc_R1", "type": "AND", "arg1_id": "NCT02612181_inc_T1", "arg2_id": "NCT02612181_inc_T2", "normalized": [] } ]

[ { "id": "NCT02613039_exc_text", "type": "exclusion", "text": [ "Participation in another clinical trial.\nKnown or suspected (or history of) malignancy or chronic illness.\nSerious organic or mental disease diagnosed by a psychiatrist (e.g., major depression currently treated with antidepressant medication) suspected on the basis of the medical history and/or clinical examination.\nConditions that may affect the compliance to the study.\nContraindications to therapy with the study drug or hypersensitivity to the study drug (active ingredient or excipients of the formulation).\n" ], "offsets": [ [ 0, 515 ] ] } ]

[ { "id": "NCT02613039_exc_T2", "type": "Mood", "text": [ "suspected" ], "offsets": [ [ 50, 59 ] ], "normalized": [] }, { "id": "NCT02613039_exc_T3", "type": "Mood", "text": [ "Known" ], "offsets": [ [ 41, 46 ] ], "normalized": [] }, { "id": "NCT02613039_exc_T4", "type": "Condition", "text": [ "malignancy" ], "offsets": [ [ 76, 86 ] ], "normalized": [] }, { "id": "NCT02613039_exc_T5", "type": "Condition", "text": [ "chronic illness" ], "offsets": [ [ 90, 105 ] ], "normalized": [] }, { "id": "NCT02613039_exc_T6", "type": "Scope", "text": [ "malignancy or chronic illness" ], "offsets": [ [ 76, 105 ] ], "normalized": [] }, { "id": "NCT02613039_exc_T7", "type": "Observation", "text": [ "history of" ], "offsets": [ [ 64, 74 ] ], "normalized": [] }, { "id": "NCT02613039_exc_T8", "type": "Scope", "text": [ "Known or suspected (or history of)" ], "offsets": [ [ 41, 75 ] ], "normalized": [] }, { "id": "NCT02613039_exc_T9", "type": "Condition", "text": [ "mental disease" ], "offsets": [ [ 126, 140 ] ], "normalized": [] }, { "id": "NCT02613039_exc_T10", "type": "Condition", "text": [ "ganic o", "sease d" ], "offsets": [ [ 117, 124 ], [ 135, 142 ] ], "normalized": [] }, { "id": "NCT02613039_exc_T11", "type": "Qualifier", "text": [ "diagnosed by a psychiatrist" ], "offsets": [ [ 141, 168 ] ], "normalized": [] }, { "id": "NCT02613039_exc_T12", "type": "Scope", "text": [ "organic or mental disease" ], "offsets": [ [ 115, 140 ] ], "normalized": [] }, { "id": "NCT02613039_exc_T13", "type": "Condition", "text": [ "major depression" ], "offsets": [ [ 176, 192 ] ], "normalized": [] }, { "id": "NCT02613039_exc_T14", "type": "Procedure", "text": [ "treated" ], "offsets": [ [ 203, 210 ] ], "normalized": [] }, { "id": "NCT02613039_exc_T15", "type": "Temporal", "text": [ "currently" ], "offsets": [ [ 193, 202 ] ], "normalized": [] }, { "id": "NCT02613039_exc_T16", "type": "Drug", "text": [ "antidepressant medication" ], "offsets": [ [ 216, 241 ] ], "normalized": [] }, { "id": "NCT02613039_exc_T17", "type": "Scope", "text": [ "organic or mental disease diagnosed by a psychiatrist" ], "offsets": [ [ 115, 168 ] ], "normalized": [] }, { "id": "NCT02613039_exc_T18", "type": "Mood", "text": [ "suspected" ], "offsets": [ [ 243, 252 ] ], "normalized": [] }, { "id": "NCT02613039_exc_T19", "type": "Observation", "text": [ "medical history" ], "offsets": [ [ 273, 288 ] ], "normalized": [] }, { "id": "NCT02613039_exc_T20", "type": "Procedure", "text": [ "clinical examination" ], "offsets": [ [ 296, 316 ] ], "normalized": [] }, { "id": "NCT02613039_exc_T21", "type": "Scope", "text": [ "medical history and/or clinical examination" ], "offsets": [ [ 273, 316 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02613039_exc_R1", "type": "Has_scope", "arg1_id": "NCT02613039_exc_T6", "arg2_id": "NCT02613039_exc_T8", "normalized": [] }, { "id": "NCT02613039_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02613039_exc_T12", "arg2_id": "NCT02613039_exc_T11", "normalized": [] }, { "id": "NCT02613039_exc_R3", "type": "Has_temporal", "arg1_id": "NCT02613039_exc_T14", "arg2_id": "NCT02613039_exc_T15", "normalized": [] }, { "id": "NCT02613039_exc_R4", "type": "AND", "arg1_id": "NCT02613039_exc_T14", "arg2_id": "NCT02613039_exc_T16", "normalized": [] }, { "id": "NCT02613039_exc_R5", "type": "AND", "arg1_id": "NCT02613039_exc_T13", "arg2_id": "NCT02613039_exc_T14", "normalized": [] }, { "id": "NCT02613039_exc_R6", "type": "Subsumes", "arg1_id": "NCT02613039_exc_T17", "arg2_id": "NCT02613039_exc_T13", "normalized": [] }, { "id": "NCT02613039_exc_R7", "type": "Has_scope", "arg1_id": "NCT02613039_exc_T18", "arg2_id": "NCT02613039_exc_T21", "normalized": [] }, { "id": "NCT02613039_exc_R8", "type": "Has_mood", "arg1_id": "NCT02613039_exc_T13", "arg2_id": "NCT02613039_exc_T18", "normalized": [] } ]

[ { "id": "NCT02613039_inc_text", "type": "inclusion", "text": [ "Female subjects aged =/> 18 years and of reproductive age.\nCapacity to give consent for study participation, after being adequately informed of the aims, benefits, risks, time and motion of the study.\n" ], "offsets": [ [ 0, 201 ] ] } ]

[ { "id": "NCT02613039_inc_T1", "type": "Person", "text": [ "Female" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "NCT02613039_inc_T2", "type": "Person", "text": [ "aged" ], "offsets": [ [ 16, 20 ] ], "normalized": [] }, { "id": "NCT02613039_inc_T3", "type": "Value", "text": [ "=/> 18 years" ], "offsets": [ [ 21, 33 ] ], "normalized": [] }, { "id": "NCT02613039_inc_T4", "type": "Condition", "text": [ "reproductive age" ], "offsets": [ [ 41, 57 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02613039_inc_R1", "type": "Has_value", "arg1_id": "NCT02613039_inc_T2", "arg2_id": "NCT02613039_inc_T3", "normalized": [] } ]

[ { "id": "NCT02618057_exc_text", "type": "exclusion", "text": [ "Immunosuppresant host\nChronic cardiovascular/pulmonary disease\nHospital acquired infection\n" ], "offsets": [ [ 0, 91 ] ] } ]

[ { "id": "NCT02618057_exc_T1", "type": "Condition", "text": [ "Immunosuppresant host" ], "offsets": [ [ 0, 21 ] ], "normalized": [] }, { "id": "NCT02618057_exc_T2", "type": "Condition", "text": [ "pulmonary disease" ], "offsets": [ [ 45, 62 ] ], "normalized": [] }, { "id": "NCT02618057_exc_T3", "type": "Condition", "text": [ "ardiovascular/", "isease" ], "offsets": [ [ 31, 45 ], [ 56, 62 ] ], "normalized": [] }, { "id": "NCT02618057_exc_T4", "type": "Temporal", "text": [ "Chronic" ], "offsets": [ [ 22, 29 ] ], "normalized": [] }, { "id": "NCT02618057_exc_T5", "type": "Scope", "text": [ "cardiovascular/pulmonary disease" ], "offsets": [ [ 30, 62 ] ], "normalized": [] }, { "id": "NCT02618057_exc_T6", "type": "Condition", "text": [ "Hospital acquired infection" ], "offsets": [ [ 63, 90 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02618057_exc_R1", "type": "Has_temporal", "arg1_id": "NCT02618057_exc_T5", "arg2_id": "NCT02618057_exc_T4", "normalized": [] } ]

[ { "id": "NCT02618057_inc_text", "type": "inclusion", "text": [ "Evidence of Mycoplasma pneumoniae infection\nLobar pneumonia or pneumoniae with pleural effusion\n" ], "offsets": [ [ 0, 96 ] ] } ]

[ { "id": "NCT02618057_inc_T1", "type": "Condition", "text": [ "Mycoplasma pneumoniae infection" ], "offsets": [ [ 12, 43 ] ], "normalized": [] }, { "id": "NCT02618057_inc_T2", "type": "Condition", "text": [ "Lobar pneumonia" ], "offsets": [ [ 44, 59 ] ], "normalized": [] }, { "id": "NCT02618057_inc_T3", "type": "Condition", "text": [ "pneumoniae" ], "offsets": [ [ 63, 73 ] ], "normalized": [] }, { "id": "NCT02618057_inc_T4", "type": "Condition", "text": [ "pleural effusion" ], "offsets": [ [ 79, 95 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02618057_inc_R1", "type": "AND", "arg1_id": "NCT02618057_inc_T3", "arg2_id": "NCT02618057_inc_T4", "normalized": [] } ]

[ { "id": "NCT02620904_exc_text", "type": "exclusion", "text": [ "NA\n\n" ], "offsets": [ [ 0, 4 ] ] } ]

[]

[]

[]

[]

[ { "id": "NCT02620904_inc_text", "type": "inclusion", "text": [ "Intrauterine fetal death as confirmed by absence of cardiac motion on ultrasound by Attending physician at the time of admission to the hospital.\nEstimated gestational age greater than 20 weeks\nHemodynamically stable and appropriate for induction of labor as per primary clinical health team in house\nWomen with one prior low transverse cesarean delivery\n" ], "offsets": [ [ 0, 355 ] ] } ]

[ { "id": "NCT02620904_inc_T1", "type": "Condition", "text": [ "Intrauterine fetal death" ], "offsets": [ [ 0, 24 ] ], "normalized": [] }, { "id": "NCT02620904_inc_T2", "type": "Condition", "text": [ "absence of cardiac motion" ], "offsets": [ [ 41, 66 ] ], "normalized": [] }, { "id": "NCT02620904_inc_T3", "type": "Procedure", "text": [ "ultrasound" ], "offsets": [ [ 70, 80 ] ], "normalized": [] }, { "id": "NCT02620904_inc_T4", "type": "Temporal", "text": [ "at the time of admission to the hospital" ], "offsets": [ [ 104, 144 ] ], "normalized": [] }, { "id": "NCT02620904_inc_T5", "type": "Reference_point", "text": [ "admission to the hospital" ], "offsets": [ [ 119, 144 ] ], "normalized": [] }, { "id": "NCT02620904_inc_T6", "type": "Measurement", "text": [ "Estimated gestational age" ], "offsets": [ [ 146, 171 ] ], "normalized": [] }, { "id": "NCT02620904_inc_T7", "type": "Value", "text": [ "greater than 20 weeks" ], "offsets": [ [ 172, 193 ] ], "normalized": [] }, { "id": "NCT02620904_inc_T8", "type": "Condition", "text": [ "Hemodynamically stable" ], "offsets": [ [ 194, 216 ] ], "normalized": [] }, { "id": "NCT02620904_inc_T9", "type": "Procedure", "text": [ "induction of labor" ], "offsets": [ [ 237, 255 ] ], "normalized": [] }, { "id": "NCT02620904_inc_T10", "type": "Person", "text": [ "Women" ], "offsets": [ [ 301, 306 ] ], "normalized": [] }, { "id": "NCT02620904_inc_T11", "type": "Multiplier", "text": [ "one" ], "offsets": [ [ 312, 315 ] ], "normalized": [] }, { "id": "NCT02620904_inc_T12", "type": "Procedure", "text": [ "low transverse cesarean delivery" ], "offsets": [ [ 322, 354 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT02620904_inc_R1", "type": "Has_index", "arg1_id": "NCT02620904_inc_T4", "arg2_id": "NCT02620904_inc_T5", "normalized": [] }, { "id": "NCT02620904_inc_R2", "type": "AND", "arg1_id": "NCT02620904_inc_T3", "arg2_id": "NCT02620904_inc_T2", "normalized": [] }, { "id": "NCT02620904_inc_R3", "type": "Has_temporal", "arg1_id": "NCT02620904_inc_T3", "arg2_id": "NCT02620904_inc_T4", "normalized": [] }, { "id": "NCT02620904_inc_R4", "type": "Has_value", "arg1_id": "NCT02620904_inc_T6", "arg2_id": "NCT02620904_inc_T7", "normalized": [] }, { "id": "NCT02620904_inc_R5", "type": "AND", "arg1_id": "NCT02620904_inc_T8", "arg2_id": "NCT02620904_inc_T9", "normalized": [] }, { "id": "NCT02620904_inc_R6", "type": "Has_multiplier", "arg1_id": "NCT02620904_inc_T12", "arg2_id": "NCT02620904_inc_T11", "normalized": [] } ]

[ { "id": "NCT02621489_exc_text", "type": "exclusion", "text": [ "Type 1 diabetes (autoantibody positive).\nAny history of receiving GLP-1 analogues or dipeptidyl peptidase inhibitors within 6 months\nKnown severe heart failure, classified as NYHA 4.\nActive myocarditis; malfunctioning artificial heart valve.\nHistory of ventricular tachycardia within 3 months before study entry; second- or third-degree atrioventricular block.\nSupine systolic blood pressure <85 mm Hg or >200 mm Hg at screening.\nPrimary renal impairment, creatinine clearance < 45 ml/min if treated with metformin.\nUncorrected hypokalemia or hyperkalemia (potassium <3.5 mmol/l or >5.5 mmol/l).\nSignificant anemia (Hb < 90 g/l)\nSevere gastrointestinal disease, including gastroparesis. As judged by the Investigator.\nBody mass index (BMI) > 45 kg/m2.\nMalignant neoplasm requiring chemotherapy, surgery, radiation or palliative therapy in the previous 5 years. Patients with intraepithelial squamous cell carcinoma of the skin treated with topical 5FU and subjects with basal cell skin cancer are allowed to enter the trial.\nFemales of child bearing potential who are pregnant, breast-feeding or intend to become pregnant.\nCurrent drug and alcohol abuse.\nHistory of acute or chronic pancreatitis\nSubjects considered by the Investigator to be unsuitable for the study.\n" ], "offsets": [ [ 0, 1268 ] ] } ]

[ { "id": "NCT02621489_exc_T1", "type": "Condition", "text": [ "Type 1 diabetes" ], "offsets": [ [ 0, 15 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T2", "type": "Measurement", "text": [ "autoantibody" ], "offsets": [ [ 17, 29 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T3", "type": "Value", "text": [ "positive" ], "offsets": [ [ 30, 38 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T4", "type": "Drug", "text": [ "GLP-1 analogues" ], "offsets": [ [ 66, 81 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T5", "type": "Drug", "text": [ "dipeptidyl peptidase inhibitors" ], "offsets": [ [ 85, 116 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T6", "type": "Scope", "text": [ "GLP-1 analogues or dipeptidyl peptidase inhibitors" ], "offsets": [ [ 66, 116 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T7", "type": "Temporal", "text": [ "within 6 months" ], "offsets": [ [ 117, 132 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T8", "type": "Condition", "text": [ "heart failure" ], "offsets": [ [ 146, 159 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T9", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 139, 145 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T10", "type": "Measurement", "text": [ "NYHA" ], "offsets": [ [ 175, 179 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T11", "type": "Value", "text": [ "4" ], "offsets": [ [ 180, 181 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T12", "type": "Condition", "text": [ "Active myocarditis" ], "offsets": [ [ 183, 201 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T13", "type": "Device", "text": [ "artificial heart valve" ], "offsets": [ [ 218, 240 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T14", "type": "Qualifier", "text": [ "malfunctioning" ], "offsets": [ [ 203, 217 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T15", "type": "Condition", "text": [ "ventricular tachycardia" ], "offsets": [ [ 253, 276 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T16", "type": "Temporal", "text": [ "within 3 months" ], "offsets": [ [ 277, 292 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T17", "type": "Condition", "text": [ "third-degree atrioventricular block" ], "offsets": [ [ 324, 359 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T18", "type": "Condition", "text": [ "nd- or", "ee atrioventricular block.\nSu" ], "offsets": [ [ 317, 323 ], [ 334, 363 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T19", "type": "Measurement", "text": [ "systolic blood pressure" ], "offsets": [ [ 368, 391 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T20", "type": "Qualifier", "text": [ "Supine" ], "offsets": [ [ 361, 367 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T21", "type": "Value", "text": [ "<85 mm Hg" ], "offsets": [ [ 392, 401 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T22", "type": "Value", "text": [ ">200 mm Hg" ], "offsets": [ [ 405, 415 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T23", "type": "Scope", "text": [ "<85 mm Hg or >200 mm Hg" ], "offsets": [ [ 392, 415 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T24", "type": "Condition", "text": [ "Primary renal impairment" ], "offsets": [ [ 430, 454 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T25", "type": "Measurement", "text": [ "creatinine clearance" ], "offsets": [ [ 456, 476 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T26", "type": "Value", "text": [ "< 45 ml/min" ], "offsets": [ [ 477, 488 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T27", "type": "Drug", "text": [ "metformin" ], "offsets": [ [ 505, 514 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T28", "type": "Condition", "text": [ "hypokalemia" ], "offsets": [ [ 528, 539 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T29", "type": "Condition", "text": [ "hyperkalemia" ], "offsets": [ [ 543, 555 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T30", "type": "Measurement", "text": [ "potassium" ], "offsets": [ [ 557, 566 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T31", "type": "Value", "text": [ "<3.5 mmol/l" ], "offsets": [ [ 567, 578 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T32", "type": "Value", "text": [ ">5.5 mmol/l" ], "offsets": [ [ 582, 593 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T33", "type": "Scope", "text": [ "<3.5 mmol/l or >5.5 mmol/l" ], "offsets": [ [ 567, 593 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T34", "type": "Scope", "text": [ "hypokalemia or hyperkalemia" ], "offsets": [ [ 528, 555 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T35", "type": "Condition", "text": [ "anemia" ], "offsets": [ [ 608, 614 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T36", "type": "Qualifier", "text": [ "Significant" ], "offsets": [ [ 596, 607 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T37", "type": "Measurement", "text": [ "Hb" ], "offsets": [ [ 616, 618 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T38", "type": "Value", "text": [ "< 90 g/l" ], "offsets": [ [ 619, 627 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T39", "type": "Condition", "text": [ "gastrointestinal disease" ], "offsets": [ [ 636, 660 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T40", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 629, 635 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T41", "type": "Condition", "text": [ "gastroparesis" ], "offsets": [ [ 672, 685 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T42", "type": "Measurement", "text": [ "Body mass index" ], "offsets": [ [ 718, 733 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T43", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 735, 738 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T44", "type": "Value", "text": [ "> 45 kg/m2" ], "offsets": [ [ 740, 750 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T45", "type": "Condition", "text": [ "Malignant neoplasm" ], "offsets": [ [ 752, 770 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T46", "type": "Procedure", "text": [ "chemotherapy" ], "offsets": [ [ 781, 793 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T47", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 795, 802 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T48", "type": "Procedure", "text": [ "radiation" ], "offsets": [ [ 804, 813 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T49", "type": "Procedure", "text": [ "palliative therapy" ], "offsets": [ [ 817, 835 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T50", "type": "Temporal", "text": [ "previous 5 years." ], "offsets": [ [ 843, 860 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T51", "type": "Scope", "text": [ "chemotherapy, surgery, radiation or palliative therapy" ], "offsets": [ [ 781, 835 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T52", "type": "Negation", "text": [ "allowed" ], "offsets": [ [ 997, 1004 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T53", "type": "Condition", "text": [ "intraepithelial squamous cell carcinoma" ], "offsets": [ [ 875, 914 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T54", "type": "Qualifier", "text": [ "skin" ], "offsets": [ [ 922, 926 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T55", "type": "Drug", "text": [ "topical 5FU" ], "offsets": [ [ 940, 951 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T56", "type": "Condition", "text": [ "basal cell skin cancer" ], "offsets": [ [ 970, 992 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T57", "type": "Scope", "text": [ "intraepithelial squamous cell carcinoma of the skin treated with topical 5FU and subjects with basal cell skin cancer" ], "offsets": [ [ 875, 992 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T59", "type": "Condition", "text": [ "alcohol abuse" ], "offsets": [ [ 1140, 1153 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T60", "type": "Condition", "text": [ "hol", "y of" ], "offsets": [ [ 1144, 1147 ], [ 1161, 1165 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T61", "type": "Condition", "text": [ "ic pa", "ubjects cons" ], "offsets": [ [ 1180, 1185 ], [ 1197, 1209 ] ], "normalized": [] }, { "id": "NCT02621489_exc_T62", "type": "Condition", "text": [ "chronic pancreatitis" ], "offsets": [ [ 1175, 1195 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02621489_exc_R1", "type": "Has_value", "arg1_id": "NCT02621489_exc_T2", "arg2_id": "NCT02621489_exc_T3", "normalized": [] }, { "id": "NCT02621489_exc_R2", "type": "Subsumes", "arg1_id": "NCT02621489_exc_T1", "arg2_id": "NCT02621489_exc_T2", "normalized": [] }, { "id": "NCT02621489_exc_R3", "type": "Has_temporal", "arg1_id": "NCT02621489_exc_T6", "arg2_id": "NCT02621489_exc_T7", "normalized": [] }, { "id": "NCT02621489_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT02621489_exc_T8", "arg2_id": "NCT02621489_exc_T9", "normalized": [] }, { "id": "NCT02621489_exc_R5", "type": "Has_value", "arg1_id": "NCT02621489_exc_T10", "arg2_id": "NCT02621489_exc_T11", "normalized": [] }, { "id": "NCT02621489_exc_R6", "type": "Subsumes", "arg1_id": "NCT02621489_exc_T8", "arg2_id": "NCT02621489_exc_T10", "normalized": [] }, { "id": "NCT02621489_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT02621489_exc_T13", "arg2_id": "NCT02621489_exc_T14", "normalized": [] }, { "id": "NCT02621489_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02621489_exc_T15", "arg2_id": "NCT02621489_exc_T16", "normalized": [] }, { "id": "NCT02621489_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT02621489_exc_T19", "arg2_id": "NCT02621489_exc_T20", "normalized": [] }, { "id": "NCT02621489_exc_R10", "type": "Has_scope", "arg1_id": "NCT02621489_exc_T19", "arg2_id": "NCT02621489_exc_T23", "normalized": [] }, { "id": "NCT02621489_exc_R11", "type": "AND", "arg1_id": "NCT02621489_exc_T24", "arg2_id": "NCT02621489_exc_T27", "normalized": [] }, { "id": "NCT02621489_exc_R12", "type": "AND", "arg1_id": "NCT02621489_exc_T24", "arg2_id": "NCT02621489_exc_T25", "normalized": [] }, { "id": "NCT02621489_exc_R13", "type": "Has_value", "arg1_id": "NCT02621489_exc_T25", "arg2_id": "NCT02621489_exc_T26", "normalized": [] }, { "id": "NCT02621489_exc_R14", "type": "Has_scope", "arg1_id": "NCT02621489_exc_T30", "arg2_id": "NCT02621489_exc_T33", "normalized": [] }, { "id": "NCT02621489_exc_R15", "type": "Subsumes", "arg1_id": "NCT02621489_exc_T34", "arg2_id": "NCT02621489_exc_T33", "normalized": [] }, { "id": "NCT02621489_exc_R16", "type": "Has_qualifier", "arg1_id": "NCT02621489_exc_T35", "arg2_id": "NCT02621489_exc_T36", "normalized": [] }, { "id": "NCT02621489_exc_R17", "type": "Has_value", "arg1_id": "NCT02621489_exc_T37", "arg2_id": "NCT02621489_exc_T38", "normalized": [] }, { "id": "NCT02621489_exc_R18", "type": "Subsumes", "arg1_id": "NCT02621489_exc_T35", "arg2_id": "NCT02621489_exc_T37", "normalized": [] }, { "id": "NCT02621489_exc_R19", "type": "Has_qualifier", "arg1_id": "NCT02621489_exc_T39", "arg2_id": "NCT02621489_exc_T40", "normalized": [] }, { "id": "NCT02621489_exc_R20", "type": "Subsumes", "arg1_id": "NCT02621489_exc_T39", "arg2_id": "NCT02621489_exc_T41", "normalized": [] }, { "id": "NCT02621489_exc_R21", "type": "Subsumes", "arg1_id": "NCT02621489_exc_T42", "arg2_id": "NCT02621489_exc_T43", "normalized": [] }, { "id": "NCT02621489_exc_R22", "type": "Has_value", "arg1_id": "NCT02621489_exc_T42", "arg2_id": "NCT02621489_exc_T44", "normalized": [] }, { "id": "NCT02621489_exc_R23", "type": "Has_scope", "arg1_id": "NCT02621489_exc_T45", "arg2_id": "NCT02621489_exc_T51", "normalized": [] }, { "id": "NCT02621489_exc_R24", "type": "Has_temporal", "arg1_id": "NCT02621489_exc_T45", "arg2_id": "NCT02621489_exc_T50", "normalized": [] }, { "id": "NCT02621489_exc_R25", "type": "Has_qualifier", "arg1_id": "NCT02621489_exc_T53", "arg2_id": "NCT02621489_exc_T54", "normalized": [] }, { "id": "NCT02621489_exc_R26", "type": "AND", "arg1_id": "NCT02621489_exc_T53", "arg2_id": "NCT02621489_exc_T55", "normalized": [] }, { "id": "NCT02621489_exc_R27", "type": "Has_negation", "arg1_id": "NCT02621489_exc_T57", "arg2_id": "NCT02621489_exc_T52", "normalized": [] } ]

[ { "id": "NCT02621489_inc_text", "type": "inclusion", "text": [ "Patients eligible for PCI with application of DES, due to ACS.\nPatients with known or newly diagnosed T2D (type 2 diabetes is diagnosed according to current WHO criteria or by the use of anti-diabetic drugs)\nMale and female subjects 18-80 years.\nHbA1c (accordingly to IFCC) 47 mmol/mol - 110 mmol/mol.\nSigned informed consent form.\n" ], "offsets": [ [ 0, 332 ] ] } ]

[ { "id": "NCT02621489_inc_T1", "type": "Procedure", "text": [ "PCI" ], "offsets": [ [ 22, 25 ] ], "normalized": [] }, { "id": "NCT02621489_inc_T2", "type": "Procedure", "text": [ "DES" ], "offsets": [ [ 46, 49 ] ], "normalized": [] }, { "id": "NCT02621489_inc_T3", "type": "Condition", "text": [ "ACS" ], "offsets": [ [ 58, 61 ] ], "normalized": [] }, { "id": "NCT02621489_inc_T4", "type": "Condition", "text": [ "T2D" ], "offsets": [ [ 102, 105 ] ], "normalized": [] }, { "id": "NCT02621489_inc_T5", "type": "Person", "text": [ "Male" ], "offsets": [ [ 208, 212 ] ], "normalized": [] }, { "id": "NCT02621489_inc_T6", "type": "Person", "text": [ "female" ], "offsets": [ [ 217, 223 ] ], "normalized": [] }, { "id": "NCT02621489_inc_T7", "type": "Person", "text": [ "years" ], "offsets": [ [ 239, 244 ] ], "normalized": [] }, { "id": "NCT02621489_inc_T8", "type": "Value", "text": [ "18-80" ], "offsets": [ [ 233, 238 ] ], "normalized": [] }, { "id": "NCT02621489_inc_T9", "type": "Measurement", "text": [ "HbA1c" ], "offsets": [ [ 246, 251 ] ], "normalized": [] }, { "id": "NCT02621489_inc_T10", "type": "Value", "text": [ "47 mmol/mol - 110 mmol/mol" ], "offsets": [ [ 274, 300 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02621489_inc_R1", "type": "AND", "arg1_id": "NCT02621489_inc_T1", "arg2_id": "NCT02621489_inc_T2", "normalized": [] }, { "id": "NCT02621489_inc_R2", "type": "AND", "arg1_id": "NCT02621489_inc_T1", "arg2_id": "NCT02621489_inc_T3", "normalized": [] }, { "id": "NCT02621489_inc_R3", "type": "Has_value", "arg1_id": "NCT02621489_inc_T7", "arg2_id": "NCT02621489_inc_T8", "normalized": [] }, { "id": "NCT02621489_inc_R4", "type": "Has_value", "arg1_id": "NCT02621489_inc_T9", "arg2_id": "NCT02621489_inc_T10", "normalized": [] } ]

[ { "id": "NCT02621541_exc_text", "type": "exclusion", "text": [ "vulnerable study subjects such as described in Finnish law concerning clinical studies (disabled, children, pregnant or breast-feeding women, prisoners) will not be included.\n" ], "offsets": [ [ 0, 175 ] ] } ]

[ { "id": "NCT02621541_exc_T1", "type": "Condition", "text": [ "vulnerable" ], "offsets": [ [ 0, 10 ] ], "normalized": [] }, { "id": "NCT02621541_exc_T2", "type": "Qualifier", "text": [ "Finnish law concerning clinical studies" ], "offsets": [ [ 47, 86 ] ], "normalized": [] }, { "id": "NCT02621541_exc_T3", "type": "Condition", "text": [ "disabled" ], "offsets": [ [ 88, 96 ] ], "normalized": [] }, { "id": "NCT02621541_exc_T4", "type": "Person", "text": [ "children" ], "offsets": [ [ 98, 106 ] ], "normalized": [] }, { "id": "NCT02621541_exc_T5", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 108, 116 ] ], "normalized": [] }, { "id": "NCT02621541_exc_T6", "type": "Condition", "text": [ "breast-feeding" ], "offsets": [ [ 120, 134 ] ], "normalized": [] }, { "id": "NCT02621541_exc_T7", "type": "Person", "text": [ "women" ], "offsets": [ [ 135, 140 ] ], "normalized": [] }, { "id": "NCT02621541_exc_T8", "type": "Observation", "text": [ "prisoners" ], "offsets": [ [ 142, 151 ] ], "normalized": [] }, { "id": "NCT02621541_exc_T9", "type": "Scope", "text": [ "vulnerable study subjects such as described in Finnish law concerning clinical studies" ], "offsets": [ [ 0, 86 ] ], "normalized": [] }, { "id": "NCT02621541_exc_T10", "type": "Scope", "text": [ "disabled, children, pregnant or breast-feeding women, prisoners" ], "offsets": [ [ 88, 151 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02621541_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02621541_exc_T1", "arg2_id": "NCT02621541_exc_T2", "normalized": [] }, { "id": "NCT02621541_exc_R2", "type": "Subsumes", "arg1_id": "NCT02621541_exc_T9", "arg2_id": "NCT02621541_exc_T10", "normalized": [] } ]

[ { "id": "NCT02621541_inc_text", "type": "inclusion", "text": [ "suspicion of nonfunctional P-NET on primary CT (i.e hypervascularity) or MRI\nsigned informed consent\n" ], "offsets": [ [ 0, 101 ] ] } ]

[ { "id": "NCT02621541_inc_T1", "type": "Condition", "text": [ "nonfunctional P-NET" ], "offsets": [ [ 13, 32 ] ], "normalized": [] }, { "id": "NCT02621541_inc_T2", "type": "Mood", "text": [ "suspicion" ], "offsets": [ [ 0, 9 ] ], "normalized": [] }, { "id": "NCT02621541_inc_T3", "type": "Procedure", "text": [ "primary CT" ], "offsets": [ [ 36, 46 ] ], "normalized": [] }, { "id": "NCT02621541_inc_T4", "type": "Condition", "text": [ "hypervascularity" ], "offsets": [ [ 52, 68 ] ], "normalized": [] }, { "id": "NCT02621541_inc_T5", "type": "Procedure", "text": [ "MRI" ], "offsets": [ [ 73, 76 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02621541_inc_R1", "type": "Has_mood", "arg1_id": "NCT02621541_inc_T1", "arg2_id": "NCT02621541_inc_T2", "normalized": [] }, { "id": "NCT02621541_inc_R2", "type": "AND", "arg1_id": "NCT02621541_inc_T1", "arg2_id": "NCT02621541_inc_T3", "normalized": [] }, { "id": "NCT02621541_inc_R3", "type": "Subsumes", "arg1_id": "NCT02621541_inc_T3", "arg2_id": "NCT02621541_inc_T4", "normalized": [] } ]

[ { "id": "NCT02624908_exc_text", "type": "exclusion", "text": [ "Type 1 diabetes\nKnown peripheral artery disease\nLiver enzymes equal or more than 1.5 times the upper limit of normal\nChronic heart failure NYHA class III or IV\nCurrent haemodialysis or peritoneal dialysis\nEnd stage liver disease, defined as acute or chronic liver disease and recent history of one of the following: ascites, encephalopathy, variceal bleeding, bilirubin equal or greater than 2.0 mg/dL, albumin equal or less than 3.5 g/ dL, prothrombin time greater or equal to 4 seconds, INR greater than or equal to 1.7 or prior liver transplant\nKnown or suspected hypersensitivity to trial products or related products\nFemale of child-bearing potential who is pregnant, breast-feeding or intends to become pregnant or is not using adequate contraceptive methods as required by law or local practice.\nExpected simultaneous participation in any other clinical trial of an investigational medicinal product.\nReceipt of any investigational medicinal product within 30 days before randomization\nCurrent or past (within the last 5 years) malignant neoplasms (except basal cell and squamous cell skin carcinoma)\nAny condition that in the investigator's opinion would make the subject unable to adhere to the trial visit schedule and procedures\nKnown history of non-compliance to treatment.\n" ], "offsets": [ [ 0, 1286 ] ] } ]

[ { "id": "NCT02624908_exc_T1", "type": "Condition", "text": [ "Type 1 diabetes" ], "offsets": [ [ 0, 15 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T2", "type": "Condition", "text": [ "peripheral artery disease" ], "offsets": [ [ 22, 47 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T3", "type": "Measurement", "text": [ "Liver enzymes" ], "offsets": [ [ 48, 61 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T4", "type": "Value", "text": [ "equal or more than 1.5 times the upper limit of normal" ], "offsets": [ [ 62, 116 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T5", "type": "Measurement", "text": [ "NYHA" ], "offsets": [ [ 139, 143 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T6", "type": "Value", "text": [ "class III or IV" ], "offsets": [ [ 144, 159 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T7", "type": "Condition", "text": [ "Chronic heart failure" ], "offsets": [ [ 117, 138 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T8", "type": "Procedure", "text": [ "haemodialysis" ], "offsets": [ [ 168, 181 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T9", "type": "Procedure", "text": [ "peritoneal dialysis" ], "offsets": [ [ 185, 204 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T10", "type": "Temporal", "text": [ "Current" ], "offsets": [ [ 160, 167 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T11", "type": "Scope", "text": [ "haemodialysis or peritoneal dialysis" ], "offsets": [ [ 168, 204 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T12", "type": "Condition", "text": [ "End stage liver disease" ], "offsets": [ [ 205, 228 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T13", "type": "Condition", "text": [ "chronic liver disease" ], "offsets": [ [ 250, 271 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T14", "type": "Condition", "text": [ " or ", " disease an" ], "offsets": [ [ 246, 250 ], [ 263, 274 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T15", "type": "Temporal", "text": [ "recent" ], "offsets": [ [ 276, 282 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T16", "type": "Condition", "text": [ "ascites" ], "offsets": [ [ 316, 323 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T17", "type": "Condition", "text": [ "encephalopathy" ], "offsets": [ [ 325, 339 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T18", "type": "Condition", "text": [ "variceal bleeding" ], "offsets": [ [ 341, 358 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T19", "type": "Measurement", "text": [ "bilirubin" ], "offsets": [ [ 360, 369 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T20", "type": "Value", "text": [ "equal or greater than 2.0 mg/dL" ], "offsets": [ [ 370, 401 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T21", "type": "Measurement", "text": [ "albumin" ], "offsets": [ [ 403, 410 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T22", "type": "Value", "text": [ "equal or less than 3.5 g/ dL" ], "offsets": [ [ 411, 439 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T23", "type": "Measurement", "text": [ "prothrombin time" ], "offsets": [ [ 441, 457 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T24", "type": "Value", "text": [ "greater or equal to 4 seconds" ], "offsets": [ [ 458, 487 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T25", "type": "Measurement", "text": [ "INR" ], "offsets": [ [ 489, 492 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T26", "type": "Value", "text": [ "greater than or equal to 1.7" ], "offsets": [ [ 493, 521 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T27", "type": "Temporal", "text": [ "prior" ], "offsets": [ [ 525, 530 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T28", "type": "Procedure", "text": [ "liver transplant" ], "offsets": [ [ 531, 547 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T29", "type": "Scope", "text": [ "ascites, encephalopathy, variceal bleeding, bilirubin equal or greater than 2.0 mg/dL, albumin equal or less than 3.5 g/ dL, prothrombin time greater or equal to 4 seconds, INR greater than or equal to 1.7 or prior liver transplant" ], "offsets": [ [ 316, 547 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T30", "type": "Scope", "text": [ "acute or chronic liver disease and recent history of one of the following: ascites, encephalopathy, variceal bleeding, bilirubin equal or greater than 2.0 mg/dL, albumin equal or less than 3.5 g/ dL, prothrombin time greater or equal to 4 seconds, INR greater than or equal to 1.7 or prior liver transplant" ], "offsets": [ [ 241, 547 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T31", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 567, 583 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T32", "type": "Drug", "text": [ "trial products" ], "offsets": [ [ 587, 601 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T33", "type": "Drug", "text": [ "related products" ], "offsets": [ [ 605, 621 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T34", "type": "Scope", "text": [ "trial products or related products" ], "offsets": [ [ 587, 621 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T35", "type": "Mood", "text": [ "suspected" ], "offsets": [ [ 557, 566 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T36", "type": "Mood", "text": [ "Known" ], "offsets": [ [ 548, 553 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T37", "type": "Scope", "text": [ "Known or suspected" ], "offsets": [ [ 548, 566 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T41", "type": "Condition", "text": [ "malignant neoplasms" ], "offsets": [ [ 1035, 1054 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T42", "type": "Temporal", "text": [ "Current" ], "offsets": [ [ 993, 1000 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T43", "type": "Temporal", "text": [ "past" ], "offsets": [ [ 1004, 1008 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T44", "type": "Temporal", "text": [ "within the last 5 years" ], "offsets": [ [ 1010, 1033 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T45", "type": "Scope", "text": [ "Current or past (within the last 5 years)" ], "offsets": [ [ 993, 1034 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T46", "type": "Condition", "text": [ " and squa", "\nAny con" ], "offsets": [ [ 1073, 1082 ], [ 1107, 1115 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T47", "type": "Condition", "text": [ "squamous cell skin carcinoma" ], "offsets": [ [ 1078, 1106 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T48", "type": "Negation", "text": [ "except" ], "offsets": [ [ 1056, 1062 ] ], "normalized": [] }, { "id": "NCT02624908_exc_T49", "type": "Scope", "text": [ "basal cell and squamous cell skin carcinoma" ], "offsets": [ [ 1063, 1106 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02624908_exc_R1", "type": "Has_value", "arg1_id": "NCT02624908_exc_T3", "arg2_id": "NCT02624908_exc_T4", "normalized": [] }, { "id": "NCT02624908_exc_R2", "type": "Has_value", "arg1_id": "NCT02624908_exc_T5", "arg2_id": "NCT02624908_exc_T6", "normalized": [] }, { "id": "NCT02624908_exc_R3", "type": "AND", "arg1_id": "NCT02624908_exc_T7", "arg2_id": "NCT02624908_exc_T5", "normalized": [] }, { "id": "NCT02624908_exc_R4", "type": "Has_temporal", "arg1_id": "NCT02624908_exc_T11", "arg2_id": "NCT02624908_exc_T10", "normalized": [] }, { "id": "NCT02624908_exc_R5", "type": "Has_value", "arg1_id": "NCT02624908_exc_T19", "arg2_id": "NCT02624908_exc_T20", "normalized": [] }, { "id": "NCT02624908_exc_R6", "type": "Has_value", "arg1_id": "NCT02624908_exc_T21", "arg2_id": "NCT02624908_exc_T22", "normalized": [] }, { "id": "NCT02624908_exc_R7", "type": "Has_value", "arg1_id": "NCT02624908_exc_T23", "arg2_id": "NCT02624908_exc_T24", "normalized": [] }, { "id": "NCT02624908_exc_R8", "type": "Has_value", "arg1_id": "NCT02624908_exc_T25", "arg2_id": "NCT02624908_exc_T26", "normalized": [] }, { "id": "NCT02624908_exc_R9", "type": "Has_temporal", "arg1_id": "NCT02624908_exc_T28", "arg2_id": "NCT02624908_exc_T27", "normalized": [] }, { "id": "NCT02624908_exc_R10", "type": "Has_temporal", "arg1_id": "NCT02624908_exc_T29", "arg2_id": "NCT02624908_exc_T15", "normalized": [] }, { "id": "NCT02624908_exc_R11", "type": "Subsumes", "arg1_id": "NCT02624908_exc_T12", "arg2_id": "NCT02624908_exc_T30", "normalized": [] }, { "id": "NCT02624908_exc_R12", "type": "Has_scope", "arg1_id": "NCT02624908_exc_T31", "arg2_id": "NCT02624908_exc_T37", "normalized": [] }, { "id": "NCT02624908_exc_R13", "type": "Has_scope", "arg1_id": "NCT02624908_exc_T31", "arg2_id": "NCT02624908_exc_T34", "normalized": [] }, { "id": "NCT02624908_exc_R14", "type": "Subsumes", "arg1_id": "NCT02624908_exc_T43", "arg2_id": "NCT02624908_exc_T44", "normalized": [] }, { "id": "NCT02624908_exc_R15", "type": "Has_scope", "arg1_id": "NCT02624908_exc_T41", "arg2_id": "NCT02624908_exc_T45", "normalized": [] }, { "id": "NCT02624908_exc_R16", "type": "Has_negation", "arg1_id": "NCT02624908_exc_T49", "arg2_id": "NCT02624908_exc_T48", "normalized": [] }, { "id": "NCT02624908_exc_R17", "type": "Has_scope", "arg1_id": "NCT02624908_exc_T41", "arg2_id": "NCT02624908_exc_T49", "normalized": [] } ]

[ { "id": "NCT02624908_inc_text", "type": "inclusion", "text": [ "use of basal-bolus insulin\nonset of diabetes after age 30\nBMI less than 35\neGFR at least 60 ml/mn\nHb A1c 7.0-10.0%\nwillingness to perform home glucose monitoring\nwillingness to transmit glucose and medication information weekly\n" ], "offsets": [ [ 0, 228 ] ] } ]

[ { "id": "NCT02624908_inc_T1", "type": "Drug", "text": [ "basal-bolus insulin" ], "offsets": [ [ 7, 26 ] ], "normalized": [] }, { "id": "NCT02624908_inc_T2", "type": "Measurement", "text": [ "onset of diabetes" ], "offsets": [ [ 27, 44 ] ], "normalized": [] }, { "id": "NCT02624908_inc_T3", "type": "Value", "text": [ "after age 30" ], "offsets": [ [ 45, 57 ] ], "normalized": [] }, { "id": "NCT02624908_inc_T4", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 58, 61 ] ], "normalized": [] }, { "id": "NCT02624908_inc_T5", "type": "Value", "text": [ "less than 35" ], "offsets": [ [ 62, 74 ] ], "normalized": [] }, { "id": "NCT02624908_inc_T6", "type": "Measurement", "text": [ "eGFR" ], "offsets": [ [ 75, 79 ] ], "normalized": [] }, { "id": "NCT02624908_inc_T7", "type": "Value", "text": [ "at least 60 ml/mn" ], "offsets": [ [ 80, 97 ] ], "normalized": [] }, { "id": "NCT02624908_inc_T8", "type": "Measurement", "text": [ "Hb A1c" ], "offsets": [ [ 98, 104 ] ], "normalized": [] }, { "id": "NCT02624908_inc_T9", "type": "Value", "text": [ "7.0-10.0%" ], "offsets": [ [ 105, 114 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02624908_inc_R1", "type": "Has_value", "arg1_id": "NCT02624908_inc_T2", "arg2_id": "NCT02624908_inc_T3", "normalized": [] }, { "id": "NCT02624908_inc_R2", "type": "Has_value", "arg1_id": "NCT02624908_inc_T4", "arg2_id": "NCT02624908_inc_T5", "normalized": [] }, { "id": "NCT02624908_inc_R3", "type": "Has_value", "arg1_id": "NCT02624908_inc_T6", "arg2_id": "NCT02624908_inc_T7", "normalized": [] }, { "id": "NCT02624908_inc_R4", "type": "Has_value", "arg1_id": "NCT02624908_inc_T8", "arg2_id": "NCT02624908_inc_T9", "normalized": [] } ]

[ { "id": "NCT02627521_exc_text", "type": "exclusion", "text": [ "Anticoagulation therapy\nPrior CABG.\nActive bleeding or at high risk of bleeding\nSevere liver or renal disease.\nHypersensitivity to ticagrelor\nHistory of intracranial hemorrhage\n" ], "offsets": [ [ 0, 177 ] ] } ]

[ { "id": "NCT02627521_exc_T1", "type": "Procedure", "text": [ "Anticoagulation therapy" ], "offsets": [ [ 0, 23 ] ], "normalized": [] }, { "id": "NCT02627521_exc_T2", "type": "Temporal", "text": [ "Prior" ], "offsets": [ [ 24, 29 ] ], "normalized": [] }, { "id": "NCT02627521_exc_T3", "type": "Procedure", "text": [ "CABG" ], "offsets": [ [ 30, 34 ] ], "normalized": [] }, { "id": "NCT02627521_exc_T4", "type": "Qualifier", "text": [ "Active" ], "offsets": [ [ 36, 42 ] ], "normalized": [] }, { "id": "NCT02627521_exc_T5", "type": "Condition", "text": [ "bleeding" ], "offsets": [ [ 43, 51 ] ], "normalized": [] }, { "id": "NCT02627521_exc_T6", "type": "Qualifier", "text": [ "at high risk" ], "offsets": [ [ 55, 67 ] ], "normalized": [] }, { "id": "NCT02627521_exc_T7", "type": "Condition", "text": [ "bleeding" ], "offsets": [ [ 71, 79 ] ], "normalized": [] }, { "id": "NCT02627521_exc_T8", "type": "Condition", "text": [ "renal disease" ], "offsets": [ [ 96, 109 ] ], "normalized": [] }, { "id": "NCT02627521_exc_T9", "type": "Condition", "text": [ "ease.\nH", "er or" ], "offsets": [ [ 105, 112 ], [ 90, 95 ] ], "normalized": [] }, { "id": "NCT02627521_exc_T10", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 80, 86 ] ], "normalized": [] }, { "id": "NCT02627521_exc_T11", "type": "Scope", "text": [ "liver or renal disease" ], "offsets": [ [ 87, 109 ] ], "normalized": [] }, { "id": "NCT02627521_exc_T12", "type": "Condition", "text": [ "Hypersensitivity" ], "offsets": [ [ 111, 127 ] ], "normalized": [] }, { "id": "NCT02627521_exc_T13", "type": "Drug", "text": [ "ticagrelor" ], "offsets": [ [ 131, 141 ] ], "normalized": [] }, { "id": "NCT02627521_exc_T14", "type": "Observation", "text": [ "History" ], "offsets": [ [ 142, 149 ] ], "normalized": [] }, { "id": "NCT02627521_exc_T15", "type": "Condition", "text": [ "intracranial hemorrhage" ], "offsets": [ [ 153, 176 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02627521_exc_R1", "type": "Has_temporal", "arg1_id": "NCT02627521_exc_T3", "arg2_id": "NCT02627521_exc_T2", "normalized": [] }, { "id": "NCT02627521_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02627521_exc_T7", "arg2_id": "NCT02627521_exc_T6", "normalized": [] }, { "id": "NCT02627521_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT02627521_exc_T5", "arg2_id": "NCT02627521_exc_T4", "normalized": [] }, { "id": "NCT02627521_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT02627521_exc_T11", "arg2_id": "NCT02627521_exc_T10", "normalized": [] }, { "id": "NCT02627521_exc_R5", "type": "AND", "arg1_id": "NCT02627521_exc_T12", "arg2_id": "NCT02627521_exc_T13", "normalized": [] }, { "id": "NCT02627521_exc_R6", "type": "Has_temporal", "arg1_id": "NCT02627521_exc_T15", "arg2_id": "NCT02627521_exc_T14", "normalized": [] } ]

[ { "id": "NCT02627521_inc_text", "type": "inclusion", "text": [ "Accepted for CABG surgery\nTreatment with Ticagrelor within 48 hours\n" ], "offsets": [ [ 0, 68 ] ] } ]

[ { "id": "NCT02627521_inc_T1", "type": "Procedure", "text": [ "CABG surgery" ], "offsets": [ [ 13, 25 ] ], "normalized": [] }, { "id": "NCT02627521_inc_T2", "type": "Mood", "text": [ "Accepted for" ], "offsets": [ [ 0, 12 ] ], "normalized": [] }, { "id": "NCT02627521_inc_T3", "type": "Drug", "text": [ "Ticagrelor" ], "offsets": [ [ 41, 51 ] ], "normalized": [] }, { "id": "NCT02627521_inc_T4", "type": "Temporal", "text": [ "within 48 hours" ], "offsets": [ [ 52, 67 ] ], "normalized": [] }, { "id": "NCT02627521_inc_T5", "type": "Procedure", "text": [ "Treatment" ], "offsets": [ [ 26, 35 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02627521_inc_R1", "type": "Has_mood", "arg1_id": "NCT02627521_inc_T1", "arg2_id": "NCT02627521_inc_T2", "normalized": [] }, { "id": "NCT02627521_inc_R2", "type": "AND", "arg1_id": "NCT02627521_inc_T5", "arg2_id": "NCT02627521_inc_T3", "normalized": [] }, { "id": "NCT02627521_inc_R3", "type": "Has_temporal", "arg1_id": "NCT02627521_inc_T5", "arg2_id": "NCT02627521_inc_T4", "normalized": [] } ]

[ { "id": "NCT02627560_exc_text", "type": "exclusion", "text": [ "pregnant or breastfeeding\nknown thromboembolic disease or with high risk of thromboembolism, warranting extra anticoagulation in connection with the procedure\nknown allergy to tranexamic acid/Cyklokapron®\n" ], "offsets": [ [ 0, 205 ] ] } ]

[ { "id": "NCT02627560_exc_T1", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT02627560_exc_T2", "type": "Observation", "text": [ "breastfeeding" ], "offsets": [ [ 12, 25 ] ], "normalized": [] }, { "id": "NCT02627560_exc_T3", "type": "Condition", "text": [ "thromboembolic disease" ], "offsets": [ [ 32, 54 ] ], "normalized": [] }, { "id": "NCT02627560_exc_T4", "type": "Mood", "text": [ "high risk of" ], "offsets": [ [ 63, 75 ] ], "normalized": [] }, { "id": "NCT02627560_exc_T5", "type": "Condition", "text": [ "thromboembolism" ], "offsets": [ [ 76, 91 ] ], "normalized": [] }, { "id": "NCT02627560_exc_T6", "type": "Procedure", "text": [ "extra anticoagulation" ], "offsets": [ [ 104, 125 ] ], "normalized": [] }, { "id": "NCT02627560_exc_T7", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 165, 172 ] ], "normalized": [] }, { "id": "NCT02627560_exc_T8", "type": "Drug", "text": [ "tranexamic acid" ], "offsets": [ [ 176, 191 ] ], "normalized": [] }, { "id": "NCT02627560_exc_T9", "type": "Drug", "text": [ "Cyklokapron" ], "offsets": [ [ 192, 203 ] ], "normalized": [] }, { "id": "NCT02627560_exc_T10", "type": "Scope", "text": [ "tranexamic acid/Cyklokapron" ], "offsets": [ [ 176, 203 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02627560_exc_R1", "type": "Has_mood", "arg1_id": "NCT02627560_exc_T5", "arg2_id": "NCT02627560_exc_T4", "normalized": [] }, { "id": "NCT02627560_exc_R2", "type": "AND", "arg1_id": "NCT02627560_exc_T5", "arg2_id": "NCT02627560_exc_T6", "normalized": [] }, { "id": "NCT02627560_exc_R3", "type": "Subsumes", "arg1_id": "NCT02627560_exc_T8", "arg2_id": "NCT02627560_exc_T9", "normalized": [] }, { "id": "NCT02627560_exc_R4", "type": "Has_scope", "arg1_id": "NCT02627560_exc_T7", "arg2_id": "NCT02627560_exc_T10", "normalized": [] } ]

[ { "id": "NCT02627560_inc_text", "type": "inclusion", "text": [ "breast cancer\nundergoing unilateral mastectomy with or without axillary node dissection\nreceived adequate oral and written information about the study and signed an informed-consent form\n" ], "offsets": [ [ 0, 187 ] ] } ]

[ { "id": "NCT02627560_inc_T1", "type": "Condition", "text": [ "breast cancer" ], "offsets": [ [ 0, 13 ] ], "normalized": [] }, { "id": "NCT02627560_inc_T2", "type": "Measurement", "text": [ "unilateral mastectomy" ], "offsets": [ [ 25, 46 ] ], "normalized": [] }, { "id": "NCT02627560_inc_T3", "type": "Temporal", "text": [ "undergoing" ], "offsets": [ [ 14, 24 ] ], "normalized": [] }, { "id": "NCT02627560_inc_T4", "type": "Procedure", "text": [ "axillary node dissection" ], "offsets": [ [ 63, 87 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02627560_inc_R1", "type": "Has_temporal", "arg1_id": "NCT02627560_inc_T2", "arg2_id": "NCT02627560_inc_T3", "normalized": [] }, { "id": "NCT02627560_inc_R2", "type": "AND", "arg1_id": "NCT02627560_inc_T2", "arg2_id": "NCT02627560_inc_T4", "normalized": [] } ]

[ { "id": "NCT02630628_exc_text", "type": "exclusion", "text": [ "Renal disease unrelated to SLE (e.g. diabetes mellitus, other glomerular or tubulointerstitial disease, renovascular disease), or transplanted kidney.\nEstimated glomerular filtration rate (eGFR by MDRD) =20 mL/min per 1.73 m2 or serum creatinine >300 micromol/L (3.39 mg/dL) at screening.\nRenal biopsy showing cellular or fibrocellular crescent in more than 25% of glomeruli.\nCNS or other severe organ manifestation of lupus that necessitate aggressive immunosuppressive therapy on its own.\nCo-morbidities that require corticosteroid therapy (e.g. asthma, inflammatory bowel disease).\nTreatment with prednisolone (or prednisone, or equivalent) at >20 mg/D for over 4 weeks within the past 3 months.\nTreatment with MMF at >1.5 g/D for over 4 weeks within the past 3 months.\nKnown hypersensitivity or intolerability to prednisolone (or prednisone, or equivalent), TAC, or MMF at a dose of 1.25 g or below per day.\nSubjects who are already on treatment with TAC, cyclosporine or any other calcineurin inhibitor for over 4 weeks within the past 12 months.\nTreatment with cyclophosphamide, leflunomide, or methotrexate for over 2 weeks, or use of biological agent(s) regardless of duration, within the past 6 months (Note: prior use of azathioprine, mizoribine, intravenous immunoglobulins and anti-malarials is allowed).\nUncontrolled hypertension with systolic BP >160 mmHg or diastolic BP >95 mmHg.\nWomen who are pregnant or breastfeeding.\nWomen with childbearing potential or their male partners, who refuse to use an effective birth control method\n" ], "offsets": [ [ 0, 1547 ] ] } ]

[ { "id": "NCT02630628_exc_T1", "type": "Condition", "text": [ "Renal disease" ], "offsets": [ [ 0, 13 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T2", "type": "Negation", "text": [ "unrelated" ], "offsets": [ [ 14, 23 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T3", "type": "Condition", "text": [ "SLE" ], "offsets": [ [ 27, 30 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T4", "type": "Condition", "text": [ "diabetes mellitus" ], "offsets": [ [ 37, 54 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T5", "type": "Condition", "text": [ "tubulointerstitial disease" ], "offsets": [ [ 76, 102 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T6", "type": "Condition", "text": [ "glomerular", "disease" ], "offsets": [ [ 62, 72 ], [ 95, 102 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T7", "type": "Condition", "text": [ "renovascular disease" ], "offsets": [ [ 104, 124 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T8", "type": "Scope", "text": [ "diabetes mellitus, other glomerular or tubulointerstitial disease, renovascular disease" ], "offsets": [ [ 37, 124 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T9", "type": "Procedure", "text": [ "transplanted kidney" ], "offsets": [ [ 130, 149 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T10", "type": "Measurement", "text": [ "Estimated glomerular filtration rate" ], "offsets": [ [ 151, 187 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T11", "type": "Measurement", "text": [ "eGFR" ], "offsets": [ [ 189, 193 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T12", "type": "Value", "text": [ "=20 mL/min per 1.73 m2" ], "offsets": [ [ 203, 225 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T13", "type": "Measurement", "text": [ "serum creatinine" ], "offsets": [ [ 229, 245 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T14", "type": "Value", "text": [ ">300 micromol/L" ], "offsets": [ [ 246, 261 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T15", "type": "Value", "text": [ "3.39 mg/dL" ], "offsets": [ [ 263, 273 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T16", "type": "Procedure", "text": [ "Renal biopsy" ], "offsets": [ [ 289, 301 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T17", "type": "Condition", "text": [ "fibrocellular crescent" ], "offsets": [ [ 322, 344 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T18", "type": "Condition", "text": [ "llular o", "escent i" ], "offsets": [ [ 312, 320 ], [ 338, 346 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T19", "type": "Multiplier", "text": [ "more than 25% of glomeruli" ], "offsets": [ [ 348, 374 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T20", "type": "Scope", "text": [ "ellular or fibrocellular crescent" ], "offsets": [ [ 311, 344 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T21", "type": "Qualifier", "text": [ "CNS" ], "offsets": [ [ 376, 379 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T22", "type": "Condition", "text": [ "lupus" ], "offsets": [ [ 419, 424 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T23", "type": "Qualifier", "text": [ "organ manifestation" ], "offsets": [ [ 396, 415 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T24", "type": "Procedure", "text": [ "immunosuppressive therapy" ], "offsets": [ [ 453, 478 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T25", "type": "Scope", "text": [ "CNS or other severe organ manifestation" ], "offsets": [ [ 376, 415 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T26", "type": "Drug", "text": [ "corticosteroid therapy" ], "offsets": [ [ 519, 541 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T27", "type": "Condition", "text": [ "asthma" ], "offsets": [ [ 548, 554 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T28", "type": "Condition", "text": [ "inflammatory bowel disease" ], "offsets": [ [ 556, 582 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T29", "type": "Condition", "text": [ "Co-morbidities" ], "offsets": [ [ 491, 505 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T30", "type": "Scope", "text": [ "asthma, inflammatory bowel disease" ], "offsets": [ [ 548, 582 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T31", "type": "Drug", "text": [ "prednisolone" ], "offsets": [ [ 600, 612 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T32", "type": "Drug", "text": [ "prednisone" ], "offsets": [ [ 617, 627 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T33", "type": "Drug", "text": [ "isone, or", "alent) at" ], "offsets": [ [ 622, 631 ], [ 637, 646 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T34", "type": "Multiplier", "text": [ ">20 mg/D for over 4 weeks" ], "offsets": [ [ 647, 672 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T35", "type": "Temporal", "text": [ "past 3 months" ], "offsets": [ [ 684, 697 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T36", "type": "Scope", "text": [ "prednisolone (or prednisone, or equivalent)" ], "offsets": [ [ 600, 643 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T37", "type": "Drug", "text": [ "MMF" ], "offsets": [ [ 714, 717 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T38", "type": "Multiplier", "text": [ ">1.5 g/D for over 4 weeks" ], "offsets": [ [ 721, 746 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T39", "type": "Temporal", "text": [ "past 3 months" ], "offsets": [ [ 758, 771 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T40", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 779, 795 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T41", "type": "Condition", "text": [ "intolerability" ], "offsets": [ [ 799, 813 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T42", "type": "Drug", "text": [ "prednisolone" ], "offsets": [ [ 817, 829 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T43", "type": "Drug", "text": [ "prednisone" ], "offsets": [ [ 834, 844 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T44", "type": "Drug", "text": [ "one, or eq", "ent), TAC," ], "offsets": [ [ 841, 851 ], [ 856, 866 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T45", "type": "Drug", "text": [ "TAC" ], "offsets": [ [ 862, 865 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T46", "type": "Drug", "text": [ "MMF" ], "offsets": [ [ 870, 873 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T47", "type": "Multiplier", "text": [ "1.25 g or below per day" ], "offsets": [ [ 887, 910 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T48", "type": "Scope", "text": [ "hypersensitivity or intolerability" ], "offsets": [ [ 779, 813 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T49", "type": "Scope", "text": [ "prednisolone (or prednisone, or equivalent), TAC, or MMF at a dose of 1.25 g or below per day" ], "offsets": [ [ 817, 910 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T50", "type": "Drug", "text": [ "TAC" ], "offsets": [ [ 955, 958 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T51", "type": "Drug", "text": [ "cyclosporine" ], "offsets": [ [ 960, 972 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T52", "type": "Drug", "text": [ "calcineurin inhibitor" ], "offsets": [ [ 986, 1007 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T53", "type": "Multiplier", "text": [ "over 4 weeks" ], "offsets": [ [ 1012, 1024 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T54", "type": "Temporal", "text": [ "past 12 months." ], "offsets": [ [ 1036, 1051 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T55", "type": "Scope", "text": [ "TAC, cyclosporine or any other calcineurin inhibitor" ], "offsets": [ [ 955, 1007 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T56", "type": "Drug", "text": [ "cyclophosphamide" ], "offsets": [ [ 1067, 1083 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T57", "type": "Drug", "text": [ "leflunomide" ], "offsets": [ [ 1085, 1096 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T58", "type": "Drug", "text": [ "methotrexate" ], "offsets": [ [ 1101, 1113 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T59", "type": "Multiplier", "text": [ "2 weeks" ], "offsets": [ [ 1123, 1130 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T60", "type": "Procedure", "text": [ "biological agent" ], "offsets": [ [ 1142, 1158 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T61", "type": "Temporal", "text": [ "past 6 months" ], "offsets": [ [ 1197, 1210 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T62", "type": "Scope", "text": [ "cyclophosphamide, leflunomide, or methotrexate" ], "offsets": [ [ 1067, 1113 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T63", "type": "Scope", "text": [ "cyclophosphamide, leflunomide, or methotrexate for over 2 weeks, or use of biological agent(s)" ], "offsets": [ [ 1067, 1161 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T64", "type": "Negation", "text": [ "allowed" ], "offsets": [ [ 1307, 1314 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T65", "type": "Drug", "text": [ "azathioprine" ], "offsets": [ [ 1231, 1243 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T66", "type": "Drug", "text": [ "mizoribine" ], "offsets": [ [ 1245, 1255 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T67", "type": "Drug", "text": [ "immunoglobulins" ], "offsets": [ [ 1269, 1284 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T68", "type": "Drug", "text": [ "anti-malarials" ], "offsets": [ [ 1289, 1303 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T69", "type": "Scope", "text": [ "azathioprine, mizoribine, intravenous immunoglobulins and anti-malarials" ], "offsets": [ [ 1231, 1303 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T70", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 1330, 1342 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T71", "type": "Qualifier", "text": [ "Uncontrolled" ], "offsets": [ [ 1317, 1329 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T72", "type": "Measurement", "text": [ "systolic BP" ], "offsets": [ [ 1348, 1359 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T73", "type": "Measurement", "text": [ "diastolic BP" ], "offsets": [ [ 1373, 1385 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T74", "type": "Value", "text": [ ">160 mmHg" ], "offsets": [ [ 1360, 1369 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T75", "type": "Value", "text": [ ">95 mmHg" ], "offsets": [ [ 1386, 1394 ] ], "normalized": [] }, { "id": "NCT02630628_exc_T76", "type": "Scope", "text": [ "systolic BP >160 mmHg or diastolic BP >95 mmHg" ], "offsets": [ [ 1348, 1394 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02630628_exc_R1", "type": "Has_negation", "arg1_id": "NCT02630628_exc_T3", "arg2_id": "NCT02630628_exc_T2", "normalized": [] }, { "id": "NCT02630628_exc_R2", "type": "AND", "arg1_id": "NCT02630628_exc_T1", "arg2_id": "NCT02630628_exc_T3", "normalized": [] }, { "id": "NCT02630628_exc_R3", "type": "Subsumes", "arg1_id": "NCT02630628_exc_T1", "arg2_id": "NCT02630628_exc_T8", "normalized": [] }, { "id": "NCT02630628_exc_R4", "type": "Subsumes", "arg1_id": "NCT02630628_exc_T14", "arg2_id": "NCT02630628_exc_T15", "normalized": [] }, { "id": "NCT02630628_exc_R5", "type": "Has_value", "arg1_id": "NCT02630628_exc_T13", "arg2_id": "NCT02630628_exc_T14", "normalized": [] }, { "id": "NCT02630628_exc_R6", "type": "Subsumes", "arg1_id": "NCT02630628_exc_T10", "arg2_id": "NCT02630628_exc_T11", "normalized": [] }, { "id": "NCT02630628_exc_R7", "type": "Has_value", "arg1_id": "NCT02630628_exc_T10", "arg2_id": "NCT02630628_exc_T12", "normalized": [] }, { "id": "NCT02630628_exc_R8", "type": "Has_multiplier", "arg1_id": "NCT02630628_exc_T20", "arg2_id": "NCT02630628_exc_T19", "normalized": [] }, { "id": "NCT02630628_exc_R9", "type": "Has_scope", "arg1_id": "NCT02630628_exc_T16", "arg2_id": "NCT02630628_exc_T20", "normalized": [] }, { "id": "NCT02630628_exc_R10", "type": "AND", "arg1_id": "NCT02630628_exc_T22", "arg2_id": "NCT02630628_exc_T24", "normalized": [] }, { "id": "NCT02630628_exc_R11", "type": "Has_scope", "arg1_id": "NCT02630628_exc_T22", "arg2_id": "NCT02630628_exc_T25", "normalized": [] }, { "id": "NCT02630628_exc_R12", "type": "AND", "arg1_id": "NCT02630628_exc_T29", "arg2_id": "NCT02630628_exc_T26", "normalized": [] }, { "id": "NCT02630628_exc_R13", "type": "Subsumes", "arg1_id": "NCT02630628_exc_T29", "arg2_id": "NCT02630628_exc_T30", "normalized": [] }, { "id": "NCT02630628_exc_R14", "type": "Has_multiplier", "arg1_id": "NCT02630628_exc_T36", "arg2_id": "NCT02630628_exc_T34", "normalized": [] }, { "id": "NCT02630628_exc_R15", "type": "Has_temporal", "arg1_id": "NCT02630628_exc_T36", "arg2_id": "NCT02630628_exc_T35", "normalized": [] }, { "id": "NCT02630628_exc_R16", "type": "Has_multiplier", "arg1_id": "NCT02630628_exc_T37", "arg2_id": "NCT02630628_exc_T38", "normalized": [] }, { "id": "NCT02630628_exc_R17", "type": "Has_temporal", "arg1_id": "NCT02630628_exc_T37", "arg2_id": "NCT02630628_exc_T39", "normalized": [] }, { "id": "NCT02630628_exc_R18", "type": "Has_multiplier", "arg1_id": "NCT02630628_exc_T46", "arg2_id": "NCT02630628_exc_T47", "normalized": [] }, { "id": "NCT02630628_exc_R19", "type": "Has_scope", "arg1_id": "NCT02630628_exc_T48", "arg2_id": "NCT02630628_exc_T49", "normalized": [] }, { "id": "NCT02630628_exc_R20", "type": "Has_multiplier", "arg1_id": "NCT02630628_exc_T55", "arg2_id": "NCT02630628_exc_T53", "normalized": [] }, { "id": "NCT02630628_exc_R21", "type": "Has_temporal", "arg1_id": "NCT02630628_exc_T55", "arg2_id": "NCT02630628_exc_T54", "normalized": [] }, { "id": "NCT02630628_exc_R22", "type": "Has_multiplier", "arg1_id": "NCT02630628_exc_T62", "arg2_id": "NCT02630628_exc_T59", "normalized": [] }, { "id": "NCT02630628_exc_R23", "type": "Has_temporal", "arg1_id": "NCT02630628_exc_T63", "arg2_id": "NCT02630628_exc_T61", "normalized": [] }, { "id": "NCT02630628_exc_R24", "type": "Has_negation", "arg1_id": "NCT02630628_exc_T69", "arg2_id": "NCT02630628_exc_T64", "normalized": [] }, { "id": "NCT02630628_exc_R25", "type": "Has_qualifier", "arg1_id": "NCT02630628_exc_T70", "arg2_id": "NCT02630628_exc_T71", "normalized": [] }, { "id": "NCT02630628_exc_R26", "type": "Has_value", "arg1_id": "NCT02630628_exc_T72", "arg2_id": "NCT02630628_exc_T74", "normalized": [] }, { "id": "NCT02630628_exc_R27", "type": "Has_value", "arg1_id": "NCT02630628_exc_T73", "arg2_id": "NCT02630628_exc_T75", "normalized": [] }, { "id": "NCT02630628_exc_R28", "type": "Subsumes", "arg1_id": "NCT02630628_exc_T70", "arg2_id": "NCT02630628_exc_T76", "normalized": [] } ]

[ { "id": "NCT02630628_inc_text", "type": "inclusion", "text": [ "Biopsy-proven LN Class III/IV±V (ISN/RPS 2003), with biopsy performed within 12 weeks of randomization.\nPositive anti-dsDNA.\nActive LN with proteinuria (urine protein/creatinine ratio >1.0 or 24-hr urine protein >1.0 g at baseline), with or without hematuria.\nBoth 'incident' (i.e. new) patients and 'flare' patients can be included.\n" ], "offsets": [ [ 0, 334 ] ] } ]

[ { "id": "NCT02630628_inc_T1", "type": "Condition", "text": [ "LN" ], "offsets": [ [ 14, 16 ] ], "normalized": [] }, { "id": "NCT02630628_inc_T2", "type": "Qualifier", "text": [ "Class III/IV±V" ], "offsets": [ [ 17, 31 ] ], "normalized": [] }, { "id": "NCT02630628_inc_T3", "type": "Procedure", "text": [ "biopsy" ], "offsets": [ [ 53, 59 ] ], "normalized": [] }, { "id": "NCT02630628_inc_T4", "type": "Temporal", "text": [ "within 12 weeks" ], "offsets": [ [ 70, 85 ] ], "normalized": [] }, { "id": "NCT02630628_inc_T5", "type": "Measurement", "text": [ "anti-dsDNA" ], "offsets": [ [ 113, 123 ] ], "normalized": [] }, { "id": "NCT02630628_inc_T6", "type": "Value", "text": [ "Positive" ], "offsets": [ [ 104, 112 ] ], "normalized": [] }, { "id": "NCT02630628_inc_T7", "type": "Condition", "text": [ "LN" ], "offsets": [ [ 132, 134 ] ], "normalized": [] }, { "id": "NCT02630628_inc_T8", "type": "Condition", "text": [ "proteinuria" ], "offsets": [ [ 140, 151 ] ], "normalized": [] }, { "id": "NCT02630628_inc_T9", "type": "Measurement", "text": [ "urine protein/creatinine ratio" ], "offsets": [ [ 153, 183 ] ], "normalized": [] }, { "id": "NCT02630628_inc_T10", "type": "Value", "text": [ ">1.0" ], "offsets": [ [ 184, 188 ] ], "normalized": [] }, { "id": "NCT02630628_inc_T11", "type": "Measurement", "text": [ "24-hr urine protein" ], "offsets": [ [ 192, 211 ] ], "normalized": [] }, { "id": "NCT02630628_inc_T12", "type": "Value", "text": [ ">1.0 g" ], "offsets": [ [ 212, 218 ] ], "normalized": [] }, { "id": "NCT02630628_inc_T13", "type": "Scope", "text": [ "urine protein/creatinine ratio >1.0 or 24-hr urine protein >1.0 g" ], "offsets": [ [ 153, 218 ] ], "normalized": [] }, { "id": "NCT02630628_inc_T14", "type": "Qualifier", "text": [ "Active" ], "offsets": [ [ 125, 131 ] ], "normalized": [] }, { "id": "NCT02630628_inc_T15", "type": "Condition", "text": [ "hematuria" ], "offsets": [ [ 249, 258 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02630628_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT02630628_inc_T1", "arg2_id": "NCT02630628_inc_T2", "normalized": [] }, { "id": "NCT02630628_inc_R2", "type": "Has_temporal", "arg1_id": "NCT02630628_inc_T3", "arg2_id": "NCT02630628_inc_T4", "normalized": [] }, { "id": "NCT02630628_inc_R3", "type": "AND", "arg1_id": "NCT02630628_inc_T1", "arg2_id": "NCT02630628_inc_T3", "normalized": [] }, { "id": "NCT02630628_inc_R4", "type": "Has_value", "arg1_id": "NCT02630628_inc_T5", "arg2_id": "NCT02630628_inc_T6", "normalized": [] }, { "id": "NCT02630628_inc_R5", "type": "Has_value", "arg1_id": "NCT02630628_inc_T9", "arg2_id": "NCT02630628_inc_T10", "normalized": [] }, { "id": "NCT02630628_inc_R6", "type": "Has_value", "arg1_id": "NCT02630628_inc_T11", "arg2_id": "NCT02630628_inc_T12", "normalized": [] }, { "id": "NCT02630628_inc_R7", "type": "Subsumes", "arg1_id": "NCT02630628_inc_T8", "arg2_id": "NCT02630628_inc_T13", "normalized": [] }, { "id": "NCT02630628_inc_R8", "type": "AND", "arg1_id": "NCT02630628_inc_T7", "arg2_id": "NCT02630628_inc_T8", "normalized": [] }, { "id": "NCT02630628_inc_R9", "type": "Has_qualifier", "arg1_id": "NCT02630628_inc_T7", "arg2_id": "NCT02630628_inc_T14", "normalized": [] } ]

[ { "id": "NCT02631512_exc_text", "type": "exclusion", "text": [ "Ulcers due to non-diabetic etiology.\nUncontrolled diabetes defined as HbA1c above 70 mmol/mol and insufficient nutritional status.\nUlcers older than 1 year.\nAny of gangrene, osteomyelitis, cellulitis, or Charcot osteoarthropathy.\n" ], "offsets": [ [ 0, 230 ] ] } ]

[ { "id": "NCT02631512_exc_T1", "type": "Condition", "text": [ "Ulcers" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "NCT02631512_exc_T2", "type": "Qualifier", "text": [ "non-diabetic" ], "offsets": [ [ 14, 26 ] ], "normalized": [] }, { "id": "NCT02631512_exc_T3", "type": "Condition", "text": [ "Uncontrolled diabetes" ], "offsets": [ [ 37, 58 ] ], "normalized": [] }, { "id": "NCT02631512_exc_T4", "type": "Measurement", "text": [ "HbA1c" ], "offsets": [ [ 70, 75 ] ], "normalized": [] }, { "id": "NCT02631512_exc_T5", "type": "Value", "text": [ "above 70 mmol/mol" ], "offsets": [ [ 76, 93 ] ], "normalized": [] }, { "id": "NCT02631512_exc_T6", "type": "Condition", "text": [ "insufficient nutritional status" ], "offsets": [ [ 98, 129 ] ], "normalized": [] }, { "id": "NCT02631512_exc_T7", "type": "Scope", "text": [ "HbA1c above 70 mmol/mol and insufficient nutritional status" ], "offsets": [ [ 70, 129 ] ], "normalized": [] }, { "id": "NCT02631512_exc_T8", "type": "Condition", "text": [ "Ulcers" ], "offsets": [ [ 131, 137 ] ], "normalized": [] }, { "id": "NCT02631512_exc_T9", "type": "Temporal", "text": [ "older than 1 year" ], "offsets": [ [ 138, 155 ] ], "normalized": [] }, { "id": "NCT02631512_exc_T10", "type": "Condition", "text": [ "gangrene" ], "offsets": [ [ 164, 172 ] ], "normalized": [] }, { "id": "NCT02631512_exc_T11", "type": "Multiplier", "text": [ "Any of" ], "offsets": [ [ 157, 163 ] ], "normalized": [] }, { "id": "NCT02631512_exc_T12", "type": "Condition", "text": [ "osteomyelitis" ], "offsets": [ [ 174, 187 ] ], "normalized": [] }, { "id": "NCT02631512_exc_T13", "type": "Condition", "text": [ "cellulitis" ], "offsets": [ [ 189, 199 ] ], "normalized": [] }, { "id": "NCT02631512_exc_T14", "type": "Condition", "text": [ "Charcot osteoarthropathy" ], "offsets": [ [ 204, 228 ] ], "normalized": [] }, { "id": "NCT02631512_exc_T15", "type": "Scope", "text": [ "gangrene, osteomyelitis, cellulitis, or Charcot osteoarthropathy" ], "offsets": [ [ 164, 228 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02631512_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02631512_exc_T1", "arg2_id": "NCT02631512_exc_T2", "normalized": [] }, { "id": "NCT02631512_exc_R2", "type": "Has_value", "arg1_id": "NCT02631512_exc_T4", "arg2_id": "NCT02631512_exc_T5", "normalized": [] }, { "id": "NCT02631512_exc_R3", "type": "Subsumes", "arg1_id": "NCT02631512_exc_T3", "arg2_id": "NCT02631512_exc_T7", "normalized": [] }, { "id": "NCT02631512_exc_R4", "type": "Has_temporal", "arg1_id": "NCT02631512_exc_T8", "arg2_id": "NCT02631512_exc_T9", "normalized": [] }, { "id": "NCT02631512_exc_R5", "type": "Has_multiplier", "arg1_id": "NCT02631512_exc_T15", "arg2_id": "NCT02631512_exc_T11", "normalized": [] } ]

[ { "id": "NCT02631512_inc_text", "type": "inclusion", "text": [ "Type I or II diabetes mellitus.\nTarget ulcer area between 0.5 and 5 sqcm, and more than 4 weeks old.\nAnkle-brachial pressure index above 0.7.\n" ], "offsets": [ [ 0, 142 ] ] } ]

[ { "id": "NCT02631512_inc_T1", "type": "Condition", "text": [ "Type", "II diabetes mellitus" ], "offsets": [ [ 0, 4 ], [ 10, 30 ] ], "normalized": [] }, { "id": "NCT02631512_inc_T2", "type": "Condition", "text": [ "Type I", "diabetes mellitus" ], "offsets": [ [ 0, 6 ], [ 13, 30 ] ], "normalized": [] }, { "id": "NCT02631512_inc_T3", "type": "Measurement", "text": [ "Target ulcer area" ], "offsets": [ [ 32, 49 ] ], "normalized": [] }, { "id": "NCT02631512_inc_T4", "type": "Value", "text": [ "between 0.5 and 5 sqcm" ], "offsets": [ [ 50, 72 ] ], "normalized": [] }, { "id": "NCT02631512_inc_T5", "type": "Temporal", "text": [ "more than 4 weeks old" ], "offsets": [ [ 78, 99 ] ], "normalized": [] }, { "id": "NCT02631512_inc_T6", "type": "Measurement", "text": [ "Ankle-brachial pressure index" ], "offsets": [ [ 101, 130 ] ], "normalized": [] }, { "id": "NCT02631512_inc_T7", "type": "Value", "text": [ "above 0.7" ], "offsets": [ [ 131, 140 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02631512_inc_R1", "type": "Has_value", "arg1_id": "NCT02631512_inc_T3", "arg2_id": "NCT02631512_inc_T4", "normalized": [] }, { "id": "NCT02631512_inc_R2", "type": "Has_temporal", "arg1_id": "NCT02631512_inc_T3", "arg2_id": "NCT02631512_inc_T5", "normalized": [] }, { "id": "NCT02631512_inc_R3", "type": "Has_value", "arg1_id": "NCT02631512_inc_T6", "arg2_id": "NCT02631512_inc_T7", "normalized": [] } ]

[ { "id": "NCT02632266_exc_text", "type": "exclusion", "text": [ "Newborn infants <28 weeks and >34 weeks gestation, those with life threatening illness, congenital and chromosomal anomalies, gastrointestinal anomalies or necrotizing enterocolitis and fed premature formula\n" ], "offsets": [ [ 0, 208 ] ] } ]

[ { "id": "NCT02632266_exc_T1", "type": "Person", "text": [ "Newborn infants" ], "offsets": [ [ 0, 15 ] ], "normalized": [] }, { "id": "NCT02632266_exc_T2", "type": "Measurement", "text": [ "gestation" ], "offsets": [ [ 40, 49 ] ], "normalized": [] }, { "id": "NCT02632266_exc_T3", "type": "Value", "text": [ "<28 weeks and >34 weeks" ], "offsets": [ [ 16, 39 ] ], "normalized": [] }, { "id": "NCT02632266_exc_T4", "type": "Condition", "text": [ "life threatening illness" ], "offsets": [ [ 62, 86 ] ], "normalized": [] }, { "id": "NCT02632266_exc_T5", "type": "Condition", "text": [ "chromosomal anomalies" ], "offsets": [ [ 103, 124 ] ], "normalized": [] }, { "id": "NCT02632266_exc_T6", "type": "Condition", "text": [ "anomalies", "congenital" ], "offsets": [ [ 115, 124 ], [ 88, 98 ] ], "normalized": [] }, { "id": "NCT02632266_exc_T7", "type": "Condition", "text": [ "gastrointestinal anomalies" ], "offsets": [ [ 126, 152 ] ], "normalized": [] }, { "id": "NCT02632266_exc_T8", "type": "Condition", "text": [ "necrotizing enterocolitis" ], "offsets": [ [ 156, 181 ] ], "normalized": [] }, { "id": "NCT02632266_exc_T9", "type": "Observation", "text": [ "fed premature formula" ], "offsets": [ [ 186, 207 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02632266_exc_R1", "type": "Has_value", "arg1_id": "NCT02632266_exc_T2", "arg2_id": "NCT02632266_exc_T3", "normalized": [] } ]

[ { "id": "NCT02632266_inc_text", "type": "inclusion", "text": [ "Inborn preterm infants born between 28 0/7 and 34 0/7 weeks gestation and fed either mother's own milk or donor human milk\n" ], "offsets": [ [ 0, 123 ] ] } ]

[ { "id": "NCT02632266_inc_T1", "type": "Person", "text": [ "infants" ], "offsets": [ [ 15, 22 ] ], "normalized": [] }, { "id": "NCT02632266_inc_T2", "type": "Value", "text": [ "between 28 0/7 and 34 0/7 weeks" ], "offsets": [ [ 28, 59 ] ], "normalized": [] }, { "id": "NCT02632266_inc_T3", "type": "Measurement", "text": [ "gestation" ], "offsets": [ [ 60, 69 ] ], "normalized": [] }, { "id": "NCT02632266_inc_T4", "type": "Condition", "text": [ "Inborn" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "NCT02632266_inc_T5", "type": "Condition", "text": [ "preterm" ], "offsets": [ [ 7, 14 ] ], "normalized": [] }, { "id": "NCT02632266_inc_T6", "type": "Observation", "text": [ "fed", "mother's own milk" ], "offsets": [ [ 74, 77 ], [ 85, 102 ] ], "normalized": [] }, { "id": "NCT02632266_inc_T7", "type": "Observation", "text": [ "donor human milk", "fed" ], "offsets": [ [ 106, 122 ], [ 74, 77 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02632266_inc_R1", "type": "AND", "arg1_id": "NCT02632266_inc_T1", "arg2_id": "NCT02632266_inc_T5", "normalized": [] }, { "id": "NCT02632266_inc_R2", "type": "AND", "arg1_id": "NCT02632266_inc_T1", "arg2_id": "NCT02632266_inc_T4", "normalized": [] }, { "id": "NCT02632266_inc_R3", "type": "Has_value", "arg1_id": "NCT02632266_inc_T3", "arg2_id": "NCT02632266_inc_T2", "normalized": [] } ]

[ { "id": "NCT02632318_exc_text", "type": "exclusion", "text": [ "Regular cigarette smoker\nAlcohol abuse\nDrug abuse\n" ], "offsets": [ [ 0, 50 ] ] } ]

[ { "id": "NCT02632318_exc_T1", "type": "Observation", "text": [ "Regular cigarette smoker" ], "offsets": [ [ 0, 24 ] ], "normalized": [] }, { "id": "NCT02632318_exc_T2", "type": "Observation", "text": [ "Alcohol abuse" ], "offsets": [ [ 25, 38 ] ], "normalized": [] }, { "id": "NCT02632318_exc_T3", "type": "Observation", "text": [ "Drug abuse" ], "offsets": [ [ 39, 49 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "NCT02632318_inc_text", "type": "inclusion", "text": [ "History of falls or dizziness at exit from bed in the morning (at least two incidents in the past year)\nAt least 20/200 corrected visual acuity\nStable health\nNormal hearing\n" ], "offsets": [ [ 0, 173 ] ] } ]

[ { "id": "NCT02632318_inc_T1", "type": "Condition", "text": [ "falls" ], "offsets": [ [ 11, 16 ] ], "normalized": [] }, { "id": "NCT02632318_inc_T2", "type": "Condition", "text": [ "dizziness" ], "offsets": [ [ 20, 29 ] ], "normalized": [] }, { "id": "NCT02632318_inc_T3", "type": "Temporal", "text": [ "at exit from bed in the morning" ], "offsets": [ [ 30, 61 ] ], "normalized": [] }, { "id": "NCT02632318_inc_T4", "type": "Multiplier", "text": [ "at least two" ], "offsets": [ [ 63, 75 ] ], "normalized": [] }, { "id": "NCT02632318_inc_T5", "type": "Condition", "text": [ "incidents" ], "offsets": [ [ 76, 85 ] ], "normalized": [] }, { "id": "NCT02632318_inc_T6", "type": "Temporal", "text": [ "in the past year" ], "offsets": [ [ 86, 102 ] ], "normalized": [] }, { "id": "NCT02632318_inc_T7", "type": "Scope", "text": [ "falls or dizziness" ], "offsets": [ [ 11, 29 ] ], "normalized": [] }, { "id": "NCT02632318_inc_T8", "type": "Value", "text": [ "At least 20/200" ], "offsets": [ [ 104, 119 ] ], "normalized": [] }, { "id": "NCT02632318_inc_T9", "type": "Measurement", "text": [ "corrected visual acuity" ], "offsets": [ [ 120, 143 ] ], "normalized": [] }, { "id": "NCT02632318_inc_T10", "type": "Condition", "text": [ "Stable health" ], "offsets": [ [ 144, 157 ] ], "normalized": [] }, { "id": "NCT02632318_inc_T11", "type": "Condition", "text": [ "Normal hearing" ], "offsets": [ [ 158, 172 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02632318_inc_R1", "type": "Has_temporal", "arg1_id": "NCT02632318_inc_T5", "arg2_id": "NCT02632318_inc_T6", "normalized": [] }, { "id": "NCT02632318_inc_R2", "type": "Has_multiplier", "arg1_id": "NCT02632318_inc_T5", "arg2_id": "NCT02632318_inc_T4", "normalized": [] }, { "id": "NCT02632318_inc_R3", "type": "Has_temporal", "arg1_id": "NCT02632318_inc_T7", "arg2_id": "NCT02632318_inc_T3", "normalized": [] }, { "id": "NCT02632318_inc_R4", "type": "Has_value", "arg1_id": "NCT02632318_inc_T9", "arg2_id": "NCT02632318_inc_T8", "normalized": [] } ]

[ { "id": "NCT02632760_exc_text", "type": "exclusion", "text": [ "Pregnancy\nKnown hypersensitivity to study drug (ferric carboxymaltose or equivalent) or its excipients\nKnown or suspected haemoglobinopathy/thalassaemia\nBone marrow disease\nHaemochromatosis\nRenal dialysis\nErythropoietin or IV iron in the previous 4 weeks\n" ], "offsets": [ [ 0, 255 ] ] } ]

[ { "id": "NCT02632760_exc_T1", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 0, 9 ] ], "normalized": [] }, { "id": "NCT02632760_exc_T2", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 16, 32 ] ], "normalized": [] }, { "id": "NCT02632760_exc_T3", "type": "Drug", "text": [ "study drug" ], "offsets": [ [ 36, 46 ] ], "normalized": [] }, { "id": "NCT02632760_exc_T4", "type": "Drug", "text": [ "ferric carboxymaltose" ], "offsets": [ [ 48, 69 ] ], "normalized": [] }, { "id": "NCT02632760_exc_T5", "type": "Condition", "text": [ "haemoglobinopathy" ], "offsets": [ [ 122, 139 ] ], "normalized": [] }, { "id": "NCT02632760_exc_T6", "type": "Condition", "text": [ "thalassaemia" ], "offsets": [ [ 140, 152 ] ], "normalized": [] }, { "id": "NCT02632760_exc_T7", "type": "Mood", "text": [ "suspected" ], "offsets": [ [ 112, 121 ] ], "normalized": [] }, { "id": "NCT02632760_exc_T8", "type": "Mood", "text": [ "Known" ], "offsets": [ [ 103, 108 ] ], "normalized": [] }, { "id": "NCT02632760_exc_T9", "type": "Scope", "text": [ "Known or suspected" ], "offsets": [ [ 103, 121 ] ], "normalized": [] }, { "id": "NCT02632760_exc_T10", "type": "Scope", "text": [ "haemoglobinopathy/thalassaemia" ], "offsets": [ [ 122, 152 ] ], "normalized": [] }, { "id": "NCT02632760_exc_T11", "type": "Condition", "text": [ "Bone marrow disease" ], "offsets": [ [ 153, 172 ] ], "normalized": [] }, { "id": "NCT02632760_exc_T12", "type": "Condition", "text": [ "Haemochromatosis" ], "offsets": [ [ 173, 189 ] ], "normalized": [] }, { "id": "NCT02632760_exc_T13", "type": "Procedure", "text": [ "Renal dialysis" ], "offsets": [ [ 190, 204 ] ], "normalized": [] }, { "id": "NCT02632760_exc_T14", "type": "Drug", "text": [ "Erythropoietin" ], "offsets": [ [ 205, 219 ] ], "normalized": [] }, { "id": "NCT02632760_exc_T15", "type": "Drug", "text": [ "IV iron" ], "offsets": [ [ 223, 230 ] ], "normalized": [] }, { "id": "NCT02632760_exc_T16", "type": "Temporal", "text": [ "in the previous 4 weeks" ], "offsets": [ [ 231, 254 ] ], "normalized": [] }, { "id": "NCT02632760_exc_T17", "type": "Scope", "text": [ "Erythropoietin or IV iron" ], "offsets": [ [ 205, 230 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02632760_exc_R1", "type": "AND", "arg1_id": "NCT02632760_exc_T2", "arg2_id": "NCT02632760_exc_T3", "normalized": [] }, { "id": "NCT02632760_exc_R2", "type": "Subsumes", "arg1_id": "NCT02632760_exc_T3", "arg2_id": "NCT02632760_exc_T4", "normalized": [] }, { "id": "NCT02632760_exc_R3", "type": "Subsumes", "arg1_id": "NCT02632760_exc_T10", "arg2_id": "NCT02632760_exc_T9", "normalized": [] }, { "id": "NCT02632760_exc_R4", "type": "Subsumes", "arg1_id": "NCT02632760_exc_T17", "arg2_id": "NCT02632760_exc_T16", "normalized": [] } ]

[ { "id": "NCT02632760_inc_text", "type": "inclusion", "text": [ "Patients with anaemia (males Hb <130 g/L, females <120 g/L) undergoing elective cardiac surgery, and available to receive trial drug 1- 10 weeks prior to surgery\n" ], "offsets": [ [ 0, 162 ] ] } ]

[ { "id": "NCT02632760_inc_T1", "type": "Condition", "text": [ "anaemia" ], "offsets": [ [ 14, 21 ] ], "normalized": [] }, { "id": "NCT02632760_inc_T2", "type": "Person", "text": [ "males" ], "offsets": [ [ 23, 28 ] ], "normalized": [] }, { "id": "NCT02632760_inc_T3", "type": "Measurement", "text": [ "Hb" ], "offsets": [ [ 29, 31 ] ], "normalized": [] }, { "id": "NCT02632760_inc_T4", "type": "Value", "text": [ "<130 g/L" ], "offsets": [ [ 32, 40 ] ], "normalized": [] }, { "id": "NCT02632760_inc_T5", "type": "Person", "text": [ "females" ], "offsets": [ [ 42, 49 ] ], "normalized": [] }, { "id": "NCT02632760_inc_T6", "type": "Value", "text": [ "<120 g/L" ], "offsets": [ [ 50, 58 ] ], "normalized": [] }, { "id": "NCT02632760_inc_T7", "type": "Scope", "text": [ "males", "<130 g/L, females <120 g/L" ], "offsets": [ [ 23, 28 ], [ 32, 58 ] ], "normalized": [] }, { "id": "NCT02632760_inc_T8", "type": "Scope", "text": [ "males Hb <130 g/L, females <120 g/L" ], "offsets": [ [ 23, 58 ] ], "normalized": [] }, { "id": "NCT02632760_inc_T9", "type": "Qualifier", "text": [ "elective" ], "offsets": [ [ 71, 79 ] ], "normalized": [] }, { "id": "NCT02632760_inc_T10", "type": "Procedure", "text": [ "cardiac surgery" ], "offsets": [ [ 80, 95 ] ], "normalized": [] }, { "id": "NCT02632760_inc_T11", "type": "Mood", "text": [ "available to receive" ], "offsets": [ [ 101, 121 ] ], "normalized": [] }, { "id": "NCT02632760_inc_T12", "type": "Drug", "text": [ "trial drug" ], "offsets": [ [ 122, 132 ] ], "normalized": [] }, { "id": "NCT02632760_inc_T13", "type": "Temporal", "text": [ "1- 10 weeks prior to surgery" ], "offsets": [ [ 133, 161 ] ], "normalized": [] }, { "id": "NCT02632760_inc_T14", "type": "Reference_point", "text": [ "surgery" ], "offsets": [ [ 154, 161 ] ], "normalized": [] }, { "id": "NCT02632760_inc_T15", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 154, 161 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02632760_inc_R1", "type": "Has_value", "arg1_id": "NCT02632760_inc_T2", "arg2_id": "NCT02632760_inc_T4", "normalized": [] }, { "id": "NCT02632760_inc_R2", "type": "Has_value", "arg1_id": "NCT02632760_inc_T5", "arg2_id": "NCT02632760_inc_T6", "normalized": [] }, { "id": "NCT02632760_inc_R3", "type": "Has_scope", "arg1_id": "NCT02632760_inc_T3", "arg2_id": "NCT02632760_inc_T7", "normalized": [] }, { "id": "NCT02632760_inc_R4", "type": "Subsumes", "arg1_id": "NCT02632760_inc_T1", "arg2_id": "NCT02632760_inc_T8", "normalized": [] }, { "id": "NCT02632760_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT02632760_inc_T10", "arg2_id": "NCT02632760_inc_T9", "normalized": [] }, { "id": "NCT02632760_inc_R6", "type": "Has_mood", "arg1_id": "NCT02632760_inc_T12", "arg2_id": "NCT02632760_inc_T11", "normalized": [] }, { "id": "NCT02632760_inc_R7", "type": "Has_temporal", "arg1_id": "NCT02632760_inc_T12", "arg2_id": "NCT02632760_inc_T13", "normalized": [] }, { "id": "NCT02632760_inc_R8", "type": "Has_index", "arg1_id": "NCT02632760_inc_T13", "arg2_id": "NCT02632760_inc_T14", "normalized": [] } ]

[ { "id": "NCT02634541_exc_text", "type": "exclusion", "text": [ "Psoriasis or psoriasis arthropathy\nInflammatory bowel disease\nUnwillingness to participate in the study with additional imaging protocols\nExpected life-span less than <1 year\nDiabetes (to improve the PET imaging quality)\nProbable noncompliance\nPregnancy\nAge <18 years or >75 years\nContraindication for adalimumab\nMethotrexate used within the previous 6 months\nA biologic medicine used within the previous 6 months\n" ], "offsets": [ [ 0, 414 ] ] } ]

[ { "id": "NCT02634541_exc_T1", "type": "Condition", "text": [ "Psoriasis" ], "offsets": [ [ 0, 9 ] ], "normalized": [] }, { "id": "NCT02634541_exc_T3", "type": "Condition", "text": [ "psoriasis arthropathy" ], "offsets": [ [ 13, 34 ] ], "normalized": [] }, { "id": "NCT02634541_exc_T2", "type": "Condition", "text": [ "Inflammatory bowel disease" ], "offsets": [ [ 35, 61 ] ], "normalized": [] }, { "id": "NCT02634541_exc_T5", "type": "Observation", "text": [ "Expected life-span" ], "offsets": [ [ 138, 156 ] ], "normalized": [] }, { "id": "NCT02634541_exc_T6", "type": "Value", "text": [ "less than <1 year" ], "offsets": [ [ 157, 174 ] ], "normalized": [] }, { "id": "NCT02634541_exc_T7", "type": "Condition", "text": [ "Diabetes" ], "offsets": [ [ 175, 183 ] ], "normalized": [] }, { "id": "NCT02634541_exc_T8", "type": "Procedure", "text": [ "PET imaging quality" ], "offsets": [ [ 200, 219 ] ], "normalized": [] }, { "id": "NCT02634541_exc_T9", "type": "Qualifier", "text": [ "Probable" ], "offsets": [ [ 221, 229 ] ], "normalized": [] }, { "id": "NCT02634541_exc_T10", "type": "Condition", "text": [ "noncompliance" ], "offsets": [ [ 230, 243 ] ], "normalized": [] }, { "id": "NCT02634541_exc_T11", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 244, 253 ] ], "normalized": [] }, { "id": "NCT02634541_exc_T12", "type": "Person", "text": [ "Age" ], "offsets": [ [ 254, 257 ] ], "normalized": [] }, { "id": "NCT02634541_exc_T13", "type": "Value", "text": [ "<18 years" ], "offsets": [ [ 258, 267 ] ], "normalized": [] }, { "id": "NCT02634541_exc_T14", "type": "Value", "text": [ ">75 years" ], "offsets": [ [ 271, 280 ] ], "normalized": [] }, { "id": "NCT02634541_exc_T15", "type": "Scope", "text": [ "<18 years or >75 years" ], "offsets": [ [ 258, 280 ] ], "normalized": [] }, { "id": "NCT02634541_exc_T16", "type": "Condition", "text": [ "Contraindication" ], "offsets": [ [ 281, 297 ] ], "normalized": [] }, { "id": "NCT02634541_exc_T17", "type": "Drug", "text": [ "adalimumab" ], "offsets": [ [ 302, 312 ] ], "normalized": [] }, { "id": "NCT02634541_exc_T18", "type": "Drug", "text": [ "Methotrexate" ], "offsets": [ [ 313, 325 ] ], "normalized": [] }, { "id": "NCT02634541_exc_T19", "type": "Temporal", "text": [ "within the previous 6 months" ], "offsets": [ [ 331, 359 ] ], "normalized": [] }, { "id": "NCT02634541_exc_T20", "type": "Drug", "text": [ "biologic medicine" ], "offsets": [ [ 362, 379 ] ], "normalized": [] }, { "id": "NCT02634541_exc_T21", "type": "Temporal", "text": [ "within the previous 6 months" ], "offsets": [ [ 385, 413 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02634541_exc_R1", "type": "Has_value", "arg1_id": "NCT02634541_exc_T5", "arg2_id": "NCT02634541_exc_T6", "normalized": [] }, { "id": "NCT02634541_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02634541_exc_T10", "arg2_id": "NCT02634541_exc_T9", "normalized": [] }, { "id": "NCT02634541_exc_R3", "type": "Has_scope", "arg1_id": "NCT02634541_exc_T12", "arg2_id": "NCT02634541_exc_T15", "normalized": [] }, { "id": "NCT02634541_exc_R4", "type": "AND", "arg1_id": "NCT02634541_exc_T16", "arg2_id": "NCT02634541_exc_T17", "normalized": [] }, { "id": "NCT02634541_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02634541_exc_T18", "arg2_id": "NCT02634541_exc_T19", "normalized": [] }, { "id": "NCT02634541_exc_R6", "type": "Has_temporal", "arg1_id": "NCT02634541_exc_T20", "arg2_id": "NCT02634541_exc_T21", "normalized": [] } ]

[ { "id": "NCT02634541_inc_text", "type": "inclusion", "text": [ "Axial spondyloarthritis (ASAS criteria) and radiologic sacroiliitis as detected either by MRI or X-ray.\n" ], "offsets": [ [ 0, 104 ] ] } ]

[ { "id": "NCT02634541_inc_T1", "type": "Condition", "text": [ "Axial spondyloarthritis" ], "offsets": [ [ 0, 23 ] ], "normalized": [] }, { "id": "NCT02634541_inc_T2", "type": "Qualifier", "text": [ "ASAS criteria" ], "offsets": [ [ 25, 38 ] ], "normalized": [] }, { "id": "NCT02634541_inc_T3", "type": "Procedure", "text": [ "radiologic" ], "offsets": [ [ 44, 54 ] ], "normalized": [] }, { "id": "NCT02634541_inc_T4", "type": "Condition", "text": [ "sacroiliitis" ], "offsets": [ [ 55, 67 ] ], "normalized": [] }, { "id": "NCT02634541_inc_T5", "type": "Procedure", "text": [ "MRI" ], "offsets": [ [ 90, 93 ] ], "normalized": [] }, { "id": "NCT02634541_inc_T6", "type": "Procedure", "text": [ "X-ray" ], "offsets": [ [ 97, 102 ] ], "normalized": [] }, { "id": "NCT02634541_inc_T7", "type": "Scope", "text": [ "MRI or X-ray" ], "offsets": [ [ 90, 102 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02634541_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT02634541_inc_T1", "arg2_id": "NCT02634541_inc_T2", "normalized": [] }, { "id": "NCT02634541_inc_R2", "type": "AND", "arg1_id": "NCT02634541_inc_T4", "arg2_id": "NCT02634541_inc_T3", "normalized": [] }, { "id": "NCT02634541_inc_R3", "type": "Has_scope", "arg1_id": "NCT02634541_inc_T4", "arg2_id": "NCT02634541_inc_T7", "normalized": [] } ]

[ { "id": "NCT02635893_exc_text", "type": "exclusion", "text": [ "Uncontrolled medical problems including pulmonary, cardiovascular or orthopedic disease,\nAny debilitating disease prior to the SCI that caused exercise intolerance\nPremorbid, ongoing major depression or psychosis, altered cognitive status\nHistory of head injury or stroke,\nMetal plate in skull\nHistory of seizures\nReceiving drugs acting primarily on the central nervous system, which lower the seizure threshold such as antipsychotic drugs (chlorpromazine, clozapine) or tricyclic antidepressants.\nPregnant females, and\nOngoing cord compression or a syrinx in the spinal cord or who suffer from a spinal cord disease such as spinal stenosis, spina bifida or herniated cervical disk.\nUncontrolled medical problems including pulmonary, cardiovascular or orthopedic disease,\nAny debilitating disease that causes exercise intolerance\nPremorbid, ongoing major depression or psychosis, altered cognitive status\nHistory of head injury or stroke,\nMetal plate in skull\nHistory of seizures\nReceiving drugs acting primarily on the central nervous system, which lower the seizure threshold such as antipsychotic drugs (chlorpromazine, clozapine) or tricyclic antidepressants.\nPregnant females, and\nOngoing cord compression or a syrinx in the spinal cord or who suffer from a spinal cord disease such as spinal stenosis, spina bifida or herniated cervical disk.\n" ], "offsets": [ [ 0, 1349 ] ] } ]

[ { "id": "NCT02635893_exc_T1", "type": "Condition", "text": [ "medical problems" ], "offsets": [ [ 13, 29 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T2", "type": "Qualifier", "text": [ "Uncontrolled" ], "offsets": [ [ 0, 12 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T3", "type": "Condition", "text": [ "pulmonary", "disease" ], "offsets": [ [ 40, 49 ], [ 80, 87 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T4", "type": "Condition", "text": [ "orthopedic disease" ], "offsets": [ [ 69, 87 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T5", "type": "Condition", "text": [ "cardiovascular", "disease" ], "offsets": [ [ 51, 65 ], [ 80, 87 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T6", "type": "Scope", "text": [ "pulmonary, cardiovascular or orthopedic disease" ], "offsets": [ [ 40, 87 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T7", "type": "Condition", "text": [ "debilitating disease" ], "offsets": [ [ 93, 113 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T8", "type": "Temporal", "text": [ "prior to the SCI" ], "offsets": [ [ 114, 130 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T9", "type": "Condition", "text": [ "exercise intolerance" ], "offsets": [ [ 143, 163 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T10", "type": "Condition", "text": [ "major depression" ], "offsets": [ [ 183, 199 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T11", "type": "Condition", "text": [ "psychosis" ], "offsets": [ [ 203, 212 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T12", "type": "Condition", "text": [ "altered cognitive status" ], "offsets": [ [ 214, 238 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T13", "type": "Temporal", "text": [ "ongoing" ], "offsets": [ [ 175, 182 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T14", "type": "Qualifier", "text": [ "Premorbid" ], "offsets": [ [ 164, 173 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T15", "type": "Scope", "text": [ "major depression or psychosis" ], "offsets": [ [ 183, 212 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T16", "type": "Condition", "text": [ "head injury" ], "offsets": [ [ 250, 261 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T17", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 265, 271 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T18", "type": "Observation", "text": [ "History of" ], "offsets": [ [ 239, 249 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T19", "type": "Device", "text": [ "Metal plate in skull" ], "offsets": [ [ 273, 293 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T20", "type": "Condition", "text": [ "seizures" ], "offsets": [ [ 305, 313 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T21", "type": "Drug", "text": [ "drugs acting primarily on the central nervous system" ], "offsets": [ [ 324, 376 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T22", "type": "Drug", "text": [ "antipsychotic drugs" ], "offsets": [ [ 420, 439 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T23", "type": "Qualifier", "text": [ "lower the seizure threshold" ], "offsets": [ [ 384, 411 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T24", "type": "Drug", "text": [ "chlorpromazine" ], "offsets": [ [ 441, 455 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T25", "type": "Drug", "text": [ "clozapine" ], "offsets": [ [ 457, 466 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T26", "type": "Drug", "text": [ "tricyclic antidepressants" ], "offsets": [ [ 471, 496 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T27", "type": "Scope", "text": [ "chlorpromazine, clozapine" ], "offsets": [ [ 441, 466 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T28", "type": "Scope", "text": [ "antipsychotic drugs (chlorpromazine, clozapine) or tricyclic antidepressants" ], "offsets": [ [ 420, 496 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T29", "type": "Scope", "text": [ "drugs acting primarily on the central nervous system, which lower the seizure threshold" ], "offsets": [ [ 324, 411 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T30", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 498, 506 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T31", "type": "Person", "text": [ "females" ], "offsets": [ [ 507, 514 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T32", "type": "Condition", "text": [ "cord compression" ], "offsets": [ [ 528, 544 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T33", "type": "Condition", "text": [ "syrinx" ], "offsets": [ [ 550, 556 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T34", "type": "Qualifier", "text": [ "spinal cord" ], "offsets": [ [ 564, 575 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T35", "type": "Condition", "text": [ "spinal cord disease" ], "offsets": [ [ 597, 616 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T36", "type": "Condition", "text": [ "spinal stenosis" ], "offsets": [ [ 625, 640 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T37", "type": "Condition", "text": [ "spina bifida" ], "offsets": [ [ 642, 654 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T38", "type": "Condition", "text": [ "herniated cervical disk" ], "offsets": [ [ 658, 681 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T39", "type": "Scope", "text": [ "spinal stenosis, spina bifida or herniated cervical disk" ], "offsets": [ [ 625, 681 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T40", "type": "Condition", "text": [ "orthopedic disease" ], "offsets": [ [ 752, 770 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T41", "type": "Condition", "text": [ "cular or ortho", "Any deb" ], "offsets": [ [ 743, 757 ], [ 772, 779 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T42", "type": "Condition", "text": [ ", cardiov", "Any deb" ], "offsets": [ [ 732, 741 ], [ 772, 779 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T43", "type": "Condition", "text": [ "medical problems" ], "offsets": [ [ 696, 712 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T44", "type": "Qualifier", "text": [ "Uncontrolled" ], "offsets": [ [ 683, 695 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T45", "type": "Scope", "text": [ "pulmonary, cardiovascular or orthopedic disease" ], "offsets": [ [ 723, 770 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T46", "type": "Scope", "text": [ "Uncontrolled medical problems" ], "offsets": [ [ 683, 712 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T47", "type": "Condition", "text": [ "debilitating disease" ], "offsets": [ [ 776, 796 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T48", "type": "Condition", "text": [ "exercise intolerance" ], "offsets": [ [ 809, 829 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T49", "type": "Qualifier", "text": [ "Premorbid" ], "offsets": [ [ 830, 839 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T50", "type": "Temporal", "text": [ "ongoing" ], "offsets": [ [ 841, 848 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T51", "type": "Condition", "text": [ "major depression" ], "offsets": [ [ 849, 865 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T52", "type": "Condition", "text": [ "psychosis" ], "offsets": [ [ 869, 878 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T53", "type": "Condition", "text": [ "altered cognitive status" ], "offsets": [ [ 880, 904 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T54", "type": "Scope", "text": [ "major depression or psychosis" ], "offsets": [ [ 849, 878 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T55", "type": "Condition", "text": [ "head injury" ], "offsets": [ [ 916, 927 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T56", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 931, 937 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T57", "type": "Observation", "text": [ "History" ], "offsets": [ [ 905, 912 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T58", "type": "Device", "text": [ "Metal plate in skull" ], "offsets": [ [ 939, 959 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T59", "type": "Condition", "text": [ "seizures" ], "offsets": [ [ 971, 979 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T60", "type": "Observation", "text": [ "History of" ], "offsets": [ [ 960, 970 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T61", "type": "Drug", "text": [ "drugs acting primarily on the central nervous system" ], "offsets": [ [ 990, 1042 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T62", "type": "Qualifier", "text": [ "lower the seizure threshold" ], "offsets": [ [ 1050, 1077 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T63", "type": "Drug", "text": [ "antipsychotic drugs" ], "offsets": [ [ 1086, 1105 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T64", "type": "Drug", "text": [ "chlorpromazine" ], "offsets": [ [ 1107, 1121 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T65", "type": "Drug", "text": [ "clozapine" ], "offsets": [ [ 1123, 1132 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T66", "type": "Drug", "text": [ "tricyclic antidepressants" ], "offsets": [ [ 1137, 1162 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T67", "type": "Scope", "text": [ "chlorpromazine, clozapine" ], "offsets": [ [ 1107, 1132 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T68", "type": "Scope", "text": [ "antipsychotic drugs (chlorpromazine, clozapine) or tricyclic antidepressants" ], "offsets": [ [ 1086, 1162 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T69", "type": "Scope", "text": [ "drugs acting primarily on the central nervous system, which lower the seizure threshold" ], "offsets": [ [ 990, 1077 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T70", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 1164, 1172 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T71", "type": "Person", "text": [ "females" ], "offsets": [ [ 1173, 1180 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T72", "type": "Condition", "text": [ "cord compression" ], "offsets": [ [ 1194, 1210 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T73", "type": "Condition", "text": [ "syrinx" ], "offsets": [ [ 1216, 1222 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T74", "type": "Qualifier", "text": [ "spinal cord" ], "offsets": [ [ 1263, 1274 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T75", "type": "Condition", "text": [ "spinal cord disease" ], "offsets": [ [ 1263, 1282 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T76", "type": "Condition", "text": [ "spinal stenosis" ], "offsets": [ [ 1291, 1306 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T77", "type": "Condition", "text": [ "spina bifida" ], "offsets": [ [ 1308, 1320 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T78", "type": "Condition", "text": [ "herniated cervical disk" ], "offsets": [ [ 1324, 1347 ] ], "normalized": [] }, { "id": "NCT02635893_exc_T79", "type": "Scope", "text": [ "spinal stenosis, spina bifida or herniated cervical disk" ], "offsets": [ [ 1291, 1347 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02635893_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT02635893_exc_T1", "arg2_id": "NCT02635893_exc_T2", "normalized": [] }, { "id": "NCT02635893_exc_R2", "type": "Subsumes", "arg1_id": "NCT02635893_exc_T1", "arg2_id": "NCT02635893_exc_T6", "normalized": [] }, { "id": "NCT02635893_exc_R3", "type": "AND", "arg1_id": "NCT02635893_exc_T7", "arg2_id": "NCT02635893_exc_T9", "normalized": [] }, { "id": "NCT02635893_exc_R4", "type": "Has_temporal", "arg1_id": "NCT02635893_exc_T7", "arg2_id": "NCT02635893_exc_T8", "normalized": [] }, { "id": "NCT02635893_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02635893_exc_T15", "arg2_id": "NCT02635893_exc_T13", "normalized": [] }, { "id": "NCT02635893_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02635893_exc_T15", "arg2_id": "NCT02635893_exc_T14", "normalized": [] }, { "id": "NCT02635893_exc_R7", "type": "Has_temporal", "arg1_id": "NCT02635893_exc_T16", "arg2_id": "NCT02635893_exc_T18", "normalized": [] }, { "id": "NCT02635893_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02635893_exc_T17", "arg2_id": "NCT02635893_exc_T18", "normalized": [] }, { "id": "NCT02635893_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT02635893_exc_T21", "arg2_id": "NCT02635893_exc_T23", "normalized": [] }, { "id": "NCT02635893_exc_R10", "type": "Subsumes", "arg1_id": "NCT02635893_exc_T22", "arg2_id": "NCT02635893_exc_T27", "normalized": [] }, { "id": "NCT02635893_exc_R11", "type": "Subsumes", "arg1_id": "NCT02635893_exc_T29", "arg2_id": "NCT02635893_exc_T27", "normalized": [] }, { "id": "NCT02635893_exc_R12", "type": "Has_qualifier", "arg1_id": "NCT02635893_exc_T33", "arg2_id": "NCT02635893_exc_T34", "normalized": [] }, { "id": "NCT02635893_exc_R13", "type": "Subsumes", "arg1_id": "NCT02635893_exc_T35", "arg2_id": "NCT02635893_exc_T39", "normalized": [] }, { "id": "NCT02635893_exc_R14", "type": "Has_qualifier", "arg1_id": "NCT02635893_exc_T43", "arg2_id": "NCT02635893_exc_T44", "normalized": [] }, { "id": "NCT02635893_exc_R15", "type": "Subsumes", "arg1_id": "NCT02635893_exc_T46", "arg2_id": "NCT02635893_exc_T45", "normalized": [] }, { "id": "NCT02635893_exc_R16", "type": "AND", "arg1_id": "NCT02635893_exc_T47", "arg2_id": "NCT02635893_exc_T48", "normalized": [] }, { "id": "NCT02635893_exc_R17", "type": "Has_temporal", "arg1_id": "NCT02635893_exc_T54", "arg2_id": "NCT02635893_exc_T50", "normalized": [] }, { "id": "NCT02635893_exc_R18", "type": "Has_qualifier", "arg1_id": "NCT02635893_exc_T54", "arg2_id": "NCT02635893_exc_T49", "normalized": [] }, { "id": "NCT02635893_exc_R19", "type": "Has_temporal", "arg1_id": "NCT02635893_exc_T55", "arg2_id": "NCT02635893_exc_T57", "normalized": [] }, { "id": "NCT02635893_exc_R20", "type": "Has_temporal", "arg1_id": "NCT02635893_exc_T56", "arg2_id": "NCT02635893_exc_T57", "normalized": [] }, { "id": "NCT02635893_exc_R21", "type": "Has_temporal", "arg1_id": "NCT02635893_exc_T59", "arg2_id": "NCT02635893_exc_T60", "normalized": [] }, { "id": "NCT02635893_exc_R22", "type": "Subsumes", "arg1_id": "NCT02635893_exc_T63", "arg2_id": "NCT02635893_exc_T67", "normalized": [] }, { "id": "NCT02635893_exc_R23", "type": "Has_qualifier", "arg1_id": "NCT02635893_exc_T61", "arg2_id": "NCT02635893_exc_T62", "normalized": [] }, { "id": "NCT02635893_exc_R24", "type": "Subsumes", "arg1_id": "NCT02635893_exc_T69", "arg2_id": "NCT02635893_exc_T68", "normalized": [] }, { "id": "NCT02635893_exc_R25", "type": "Has_qualifier", "arg1_id": "NCT02635893_exc_T73", "arg2_id": "NCT02635893_exc_T74", "normalized": [] }, { "id": "NCT02635893_exc_R26", "type": "Subsumes", "arg1_id": "NCT02635893_exc_T75", "arg2_id": "NCT02635893_exc_T79", "normalized": [] } ]

[ { "id": "NCT02635893_inc_text", "type": "inclusion", "text": [ "Male and females between ages 18-85 years of age\nSCI ( =1 month of injury)\nASIA A, B,C and D\nSCI above L5\nAble to perform a visible contraction with dorsiflexor and hip flexor muscles (allowing testing of largely impaired patients)\nAble to ambulate a few steps with or without an assistive device\nMale and females between ages 18-85 years of age\nAble to walk and complete lower-limb tests with both legs\n" ], "offsets": [ [ 0, 404 ] ] } ]

[ { "id": "NCT02635893_inc_T1", "type": "Person", "text": [ "Male" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "NCT02635893_inc_T2", "type": "Person", "text": [ "females" ], "offsets": [ [ 9, 16 ] ], "normalized": [] }, { "id": "NCT02635893_inc_T3", "type": "Value", "text": [ "between", "18-85 years of age" ], "offsets": [ [ 17, 24 ], [ 30, 48 ] ], "normalized": [] }, { "id": "NCT02635893_inc_T4", "type": "Person", "text": [ "ages" ], "offsets": [ [ 25, 29 ] ], "normalized": [] }, { "id": "NCT02635893_inc_T5", "type": "Condition", "text": [ "SCI" ], "offsets": [ [ 49, 52 ] ], "normalized": [] }, { "id": "NCT02635893_inc_T6", "type": "Temporal", "text": [ "=1 month of injury" ], "offsets": [ [ 55, 73 ] ], "normalized": [] }, { "id": "NCT02635893_inc_T7", "type": "Measurement", "text": [ "ASIA" ], "offsets": [ [ 75, 79 ] ], "normalized": [] }, { "id": "NCT02635893_inc_T8", "type": "Value", "text": [ "A, B,C and D" ], "offsets": [ [ 80, 92 ] ], "normalized": [] }, { "id": "NCT02635893_inc_T9", "type": "Measurement", "text": [ "SCI" ], "offsets": [ [ 93, 96 ] ], "normalized": [] }, { "id": "NCT02635893_inc_T10", "type": "Value", "text": [ "above L5" ], "offsets": [ [ 97, 105 ] ], "normalized": [] }, { "id": "NCT02635893_inc_T13", "type": "Person", "text": [ "females" ], "offsets": [ [ 306, 313 ] ], "normalized": [] }, { "id": "NCT02635893_inc_T14", "type": "Person", "text": [ "l" ], "offsets": [ [ 310, 311 ] ], "normalized": [] }, { "id": "NCT02635893_inc_T15", "type": "Value", "text": [ "n ages", "years of age\nAble" ], "offsets": [ [ 320, 326 ], [ 333, 350 ] ], "normalized": [] }, { "id": "NCT02635893_inc_T16", "type": "Person", "text": [ "ages" ], "offsets": [ [ 322, 326 ] ], "normalized": [] }, { "id": "NCT02635893_inc_T17", "type": "Condition", "text": [ "Able to walk" ], "offsets": [ [ 346, 358 ] ], "normalized": [] }, { "id": "NCT02635893_inc_T18", "type": "Condition", "text": [ "Able to ambulate a few steps" ], "offsets": [ [ 232, 260 ] ], "normalized": [] }, { "id": "NCT02635893_inc_T12", "type": "Qualifier", "text": [ "without an assistive device" ], "offsets": [ [ 269, 296 ] ], "normalized": [] }, { "id": "NCT02635893_inc_T19", "type": "Qualifier", "text": [ "or w", "tive device\nMale" ], "offsets": [ [ 266, 270 ], [ 285, 301 ] ], "normalized": [] }, { "id": "NCT02635893_inc_T20", "type": "Scope", "text": [ "with or without an assistive device" ], "offsets": [ [ 261, 296 ] ], "normalized": [] }, { "id": "NCT02635893_inc_T21", "type": "Condition", "text": [ " walk ", "e lower-limb tests with b" ], "offsets": [ [ 353, 359 ], [ 370, 395 ] ], "normalized": [] }, { "id": "NCT02635893_inc_T22", "type": "Qualifier", "text": [ "with both legs" ], "offsets": [ [ 389, 403 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02635893_inc_R1", "type": "Has_value", "arg1_id": "NCT02635893_inc_T4", "arg2_id": "NCT02635893_inc_T3", "normalized": [] }, { "id": "NCT02635893_inc_R2", "type": "Has_temporal", "arg1_id": "NCT02635893_inc_T5", "arg2_id": "NCT02635893_inc_T6", "normalized": [] }, { "id": "NCT02635893_inc_R3", "type": "Has_value", "arg1_id": "NCT02635893_inc_T7", "arg2_id": "NCT02635893_inc_T8", "normalized": [] }, { "id": "NCT02635893_inc_R4", "type": "Has_value", "arg1_id": "NCT02635893_inc_T9", "arg2_id": "NCT02635893_inc_T10", "normalized": [] }, { "id": "NCT02635893_inc_R5", "type": "Has_value", "arg1_id": "NCT02635893_inc_T16", "arg2_id": "NCT02635893_inc_T15", "normalized": [] }, { "id": "NCT02635893_inc_R6", "type": "Has_scope", "arg1_id": "NCT02635893_inc_T18", "arg2_id": "NCT02635893_inc_T20", "normalized": [] }, { "id": "NCT02635893_inc_R7", "type": "Has_qualifier", "arg1_id": "NCT02635893_inc_T21", "arg2_id": "NCT02635893_inc_T22", "normalized": [] } ]

[ { "id": "NCT02637076_exc_text", "type": "exclusion", "text": [ "use of any sedative hypnotics, tranquilizers, anticonvulsants, antihistamines (except non-sedating), benzodiazepines, clonidine or any medication known to affect dopamine at start of baseline period\nsignificant unstable or uncontrolled medical/psychiatric disease\nsignificant history of head trauma/surgery or seizure disorder\nradiation exposure exceeding 20mSv in last 12 months\npregnancy\nsubstance abuse/dependence (including alcohol)\nhave sleep apnea, or are shift workers\non a sodium-restricted diet\nhas ever taken Xyrem / sodium oxybate / GHB at any time\nclaustrophobia\nmetal implants / objects in the body that may interfere with MRI\nsuccinic semialdehyde dehydrogenase deficiency\n" ], "offsets": [ [ 0, 687 ] ] } ]

[ { "id": "NCT02637076_exc_T1", "type": "Drug", "text": [ "sedative hypnotics" ], "offsets": [ [ 11, 29 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T2", "type": "Drug", "text": [ "tranquilizers" ], "offsets": [ [ 31, 44 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T3", "type": "Drug", "text": [ "anticonvulsants" ], "offsets": [ [ 46, 61 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T4", "type": "Drug", "text": [ "antihistamines" ], "offsets": [ [ 63, 77 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T5", "type": "Qualifier", "text": [ "non-sedating" ], "offsets": [ [ 86, 98 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T6", "type": "Negation", "text": [ "except" ], "offsets": [ [ 79, 85 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T7", "type": "Drug", "text": [ "benzodiazepines" ], "offsets": [ [ 101, 116 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T8", "type": "Drug", "text": [ "clonidine" ], "offsets": [ [ 118, 127 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T9", "type": "Drug", "text": [ "medication known to affect dopamine" ], "offsets": [ [ 135, 170 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T10", "type": "Temporal", "text": [ "at start of baseline period" ], "offsets": [ [ 171, 198 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T11", "type": "Scope", "text": [ "sedative hypnotics, tranquilizers, anticonvulsants, antihistamines (except non-sedating), benzodiazepines, clonidine or any medication known to affect dopamine" ], "offsets": [ [ 11, 170 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T12", "type": "Qualifier", "text": [ "significant" ], "offsets": [ [ 199, 210 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T13", "type": "Qualifier", "text": [ "uncontrolled" ], "offsets": [ [ 223, 235 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T14", "type": "Qualifier", "text": [ "unstable" ], "offsets": [ [ 211, 219 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T15", "type": "Scope", "text": [ "unstable or uncontrolled" ], "offsets": [ [ 211, 235 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T16", "type": "Condition", "text": [ "psychiatric disease" ], "offsets": [ [ 244, 263 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T17", "type": "Condition", "text": [ "edical/", "isease" ], "offsets": [ [ 237, 244 ], [ 257, 263 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T18", "type": "Scope", "text": [ "medical/psychiatric disease" ], "offsets": [ [ 236, 263 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T19", "type": "Condition", "text": [ "head trauma" ], "offsets": [ [ 287, 298 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T20", "type": "Procedure", "text": [ "ad t", "rgery o" ], "offsets": [ [ 289, 293 ], [ 301, 308 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T21", "type": "Condition", "text": [ "seizure disorder" ], "offsets": [ [ 310, 326 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T22", "type": "Observation", "text": [ "history" ], "offsets": [ [ 276, 283 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T23", "type": "Scope", "text": [ "head trauma/surgery or seizure disorder" ], "offsets": [ [ 287, 326 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T24", "type": "Qualifier", "text": [ "significant" ], "offsets": [ [ 264, 275 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T25", "type": "Condition", "text": [ "radiation exposure" ], "offsets": [ [ 327, 345 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T26", "type": "Value", "text": [ "exceeding 20mSv" ], "offsets": [ [ 346, 361 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T27", "type": "Temporal", "text": [ "in last 12 months" ], "offsets": [ [ 362, 379 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T28", "type": "Condition", "text": [ "pregnancy" ], "offsets": [ [ 380, 389 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T29", "type": "Condition", "text": [ "substance abuse" ], "offsets": [ [ 390, 405 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T30", "type": "Condition", "text": [ "ance abus", "dence (inc" ], "offsets": [ [ 395, 404 ], [ 411, 421 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T31", "type": "Drug", "text": [ "alcohol" ], "offsets": [ [ 428, 435 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T32", "type": "Scope", "text": [ "substance abuse/dependence" ], "offsets": [ [ 390, 416 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T33", "type": "Condition", "text": [ "sleep apnea" ], "offsets": [ [ 442, 453 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T34", "type": "Person", "text": [ "shift workers" ], "offsets": [ [ 462, 475 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T35", "type": "Procedure", "text": [ "sodium-restricted diet" ], "offsets": [ [ 481, 503 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T36", "type": "Drug", "text": [ "Xyrem" ], "offsets": [ [ 519, 524 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T37", "type": "Drug", "text": [ "sodium oxybate" ], "offsets": [ [ 527, 541 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T38", "type": "Drug", "text": [ "GHB" ], "offsets": [ [ 544, 547 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T39", "type": "Temporal", "text": [ "ever" ], "offsets": [ [ 508, 512 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T40", "type": "Scope", "text": [ "Xyrem / sodium oxybate / GHB" ], "offsets": [ [ 519, 547 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T41", "type": "Condition", "text": [ "claustrophobia" ], "offsets": [ [ 560, 574 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T42", "type": "Device", "text": [ "metal implants" ], "offsets": [ [ 575, 589 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T43", "type": "Device", "text": [ "ants", " the b" ], "offsets": [ [ 585, 589 ], [ 602, 608 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T44", "type": "Mood", "text": [ "may interfere with" ], "offsets": [ [ 617, 635 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T45", "type": "Procedure", "text": [ "MRI" ], "offsets": [ [ 636, 639 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T46", "type": "Scope", "text": [ "metal implants / objects" ], "offsets": [ [ 575, 599 ] ], "normalized": [] }, { "id": "NCT02637076_exc_T47", "type": "Condition", "text": [ "succinic semialdehyde dehydrogenase deficiency" ], "offsets": [ [ 640, 686 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02637076_exc_R1", "type": "Has_negation", "arg1_id": "NCT02637076_exc_T5", "arg2_id": "NCT02637076_exc_T6", "normalized": [] }, { "id": "NCT02637076_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02637076_exc_T4", "arg2_id": "NCT02637076_exc_T5", "normalized": [] }, { "id": "NCT02637076_exc_R3", "type": "Has_temporal", "arg1_id": "NCT02637076_exc_T11", "arg2_id": "NCT02637076_exc_T10", "normalized": [] }, { "id": "NCT02637076_exc_R4", "type": "Has_scope", "arg1_id": "NCT02637076_exc_T18", "arg2_id": "NCT02637076_exc_T15", "normalized": [] }, { "id": "NCT02637076_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02637076_exc_T18", "arg2_id": "NCT02637076_exc_T12", "normalized": [] }, { "id": "NCT02637076_exc_R6", "type": "Has_temporal", "arg1_id": "NCT02637076_exc_T23", "arg2_id": "NCT02637076_exc_T22", "normalized": [] }, { "id": "NCT02637076_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT02637076_exc_T22", "arg2_id": "NCT02637076_exc_T24", "normalized": [] }, { "id": "NCT02637076_exc_R8", "type": "Has_value", "arg1_id": "NCT02637076_exc_T25", "arg2_id": "NCT02637076_exc_T26", "normalized": [] }, { "id": "NCT02637076_exc_R9", "type": "Has_temporal", "arg1_id": "NCT02637076_exc_T25", "arg2_id": "NCT02637076_exc_T27", "normalized": [] }, { "id": "NCT02637076_exc_R10", "type": "Subsumes", "arg1_id": "NCT02637076_exc_T32", "arg2_id": "NCT02637076_exc_T31", "normalized": [] }, { "id": "NCT02637076_exc_R11", "type": "Has_temporal", "arg1_id": "NCT02637076_exc_T40", "arg2_id": "NCT02637076_exc_T39", "normalized": [] }, { "id": "NCT02637076_exc_R12", "type": "Has_mood", "arg1_id": "NCT02637076_exc_T45", "arg2_id": "NCT02637076_exc_T44", "normalized": [] }, { "id": "NCT02637076_exc_R13", "type": "AND", "arg1_id": "NCT02637076_exc_T46", "arg2_id": "NCT02637076_exc_T45", "normalized": [] } ]

[ { "id": "NCT02637076_inc_text", "type": "inclusion", "text": [ "current diagnosis of narcolepsy with cataplexy OR healthy control\n" ], "offsets": [ [ 0, 66 ] ] } ]

[ { "id": "NCT02637076_inc_T1", "type": "Condition", "text": [ "narcolepsy" ], "offsets": [ [ 21, 31 ] ], "normalized": [] }, { "id": "NCT02637076_inc_T2", "type": "Condition", "text": [ "cataplexy" ], "offsets": [ [ 37, 46 ] ], "normalized": [] }, { "id": "NCT02637076_inc_T3", "type": "Condition", "text": [ "healthy" ], "offsets": [ [ 50, 57 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02637076_inc_R1", "type": "AND", "arg1_id": "NCT02637076_inc_T1", "arg2_id": "NCT02637076_inc_T2", "normalized": [] } ]

[ { "id": "NCT02637453_exc_text", "type": "exclusion", "text": [ "With acute diseases, such as acute phase after myocardial infarction (within 3 months), within 3 months after acute heart failure or new cerebral infarction;\nIn the list of heart transplantation;\nExpected survival less than 1 year;\nWith other hemorrhagic diseases and anticoagulant therapy is not allowed;\nThrombosis in left atrium;\nHeart failure, New York Heart Association(NYHA) III/IV or eject fraction(EF)<40%;\nPatients with uncontrolled cancer;\nSignificant hepatic or renal impairment (and/or alanine transaminase(ALT) or Aspartate transaminase(AST) >2 times upper limit of normal, creatinine clearance rate(CCr)<50%);\nPrevious catheter radiofrequency ablation for AF or cardiac surgery;\nPregnant and lactating women, women who plan to become pregnant, or women of child bearing age not using reliable contraceptive measures.\n" ], "offsets": [ [ 0, 831 ] ] } ]

[ { "id": "NCT02637453_exc_T1", "type": "Condition", "text": [ "acute diseases" ], "offsets": [ [ 5, 19 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T2", "type": "Temporal", "text": [ "acute phase" ], "offsets": [ [ 29, 40 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T3", "type": "Condition", "text": [ "myocardial infarction" ], "offsets": [ [ 47, 68 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T4", "type": "Temporal", "text": [ "within 3 months" ], "offsets": [ [ 70, 85 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T5", "type": "Temporal", "text": [ "within 3 months" ], "offsets": [ [ 88, 103 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T6", "type": "Condition", "text": [ "acute heart failure" ], "offsets": [ [ 110, 129 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T7", "type": "Condition", "text": [ "cerebral infarction" ], "offsets": [ [ 137, 156 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T8", "type": "Scope", "text": [ "acute heart failure or new cerebral infarction" ], "offsets": [ [ 110, 156 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T9", "type": "Scope", "text": [ "acute phase after myocardial infarction (within 3 months), within 3 months after acute heart failure or new cerebral infarction" ], "offsets": [ [ 29, 156 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T10", "type": "Procedure", "text": [ "heart transplantation" ], "offsets": [ [ 173, 194 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T11", "type": "Mood", "text": [ "In the list" ], "offsets": [ [ 158, 169 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T12", "type": "Observation", "text": [ "Expected survival" ], "offsets": [ [ 196, 213 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T13", "type": "Value", "text": [ "less than 1 year" ], "offsets": [ [ 214, 230 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T14", "type": "Condition", "text": [ "hemorrhagic diseases" ], "offsets": [ [ 243, 263 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T15", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 237, 242 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T16", "type": "Procedure", "text": [ "anticoagulant therapy" ], "offsets": [ [ 268, 289 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T17", "type": "Condition", "text": [ "not allowed" ], "offsets": [ [ 293, 304 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T18", "type": "Condition", "text": [ "Thrombosis" ], "offsets": [ [ 306, 316 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T19", "type": "Qualifier", "text": [ "left atrium" ], "offsets": [ [ 320, 331 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T20", "type": "Condition", "text": [ "Heart failure" ], "offsets": [ [ 333, 346 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T21", "type": "Measurement", "text": [ "New York Heart Association(NYHA)" ], "offsets": [ [ 348, 380 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T22", "type": "Value", "text": [ "III/IV" ], "offsets": [ [ 381, 387 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T23", "type": "Measurement", "text": [ "eject fraction(EF)" ], "offsets": [ [ 391, 409 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T24", "type": "Value", "text": [ "<40%" ], "offsets": [ [ 409, 413 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T25", "type": "Qualifier", "text": [ "uncontrolled" ], "offsets": [ [ 429, 441 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T26", "type": "Condition", "text": [ "cancer" ], "offsets": [ [ 442, 448 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T27", "type": "Condition", "text": [ "renal impairment" ], "offsets": [ [ 473, 489 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T28", "type": "Condition", "text": [ " or re", "ent (and/o" ], "offsets": [ [ 469, 475 ], [ 486, 496 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T29", "type": "Qualifier", "text": [ "Significant" ], "offsets": [ [ 450, 461 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T30", "type": "Scope", "text": [ "hepatic or renal impairment" ], "offsets": [ [ 462, 489 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T31", "type": "Measurement", "text": [ "alanine transaminase(ALT)" ], "offsets": [ [ 498, 523 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T32", "type": "Measurement", "text": [ "Aspartate transaminase(AST)" ], "offsets": [ [ 527, 554 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T33", "type": "Value", "text": [ ">2 times upper limit of normal" ], "offsets": [ [ 555, 585 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T34", "type": "Measurement", "text": [ "creatinine clearance rate(CCr)" ], "offsets": [ [ 587, 617 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T35", "type": "Value", "text": [ "<50%" ], "offsets": [ [ 617, 621 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T36", "type": "Scope", "text": [ "alanine transaminase(ALT) or Aspartate transaminase(AST) >2 times upper limit of normal, creatinine clearance rate(CCr)<50%" ], "offsets": [ [ 498, 621 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T37", "type": "Procedure", "text": [ "catheter radiofrequency ablation" ], "offsets": [ [ 633, 665 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T38", "type": "Condition", "text": [ "AF" ], "offsets": [ [ 670, 672 ] ], "normalized": [] }, { "id": "NCT02637453_exc_T39", "type": "Procedure", "text": [ "cardiac surgery" ], "offsets": [ [ 676, 691 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02637453_exc_R1", "type": "Has_temporal", "arg1_id": "NCT02637453_exc_T3", "arg2_id": "NCT02637453_exc_T2", "normalized": [] }, { "id": "NCT02637453_exc_R2", "type": "Subsumes", "arg1_id": "NCT02637453_exc_T2", "arg2_id": "NCT02637453_exc_T4", "normalized": [] }, { "id": "NCT02637453_exc_R3", "type": "Has_temporal", "arg1_id": "NCT02637453_exc_T8", "arg2_id": "NCT02637453_exc_T5", "normalized": [] }, { "id": "NCT02637453_exc_R4", "type": "Subsumes", "arg1_id": "NCT02637453_exc_T1", "arg2_id": "NCT02637453_exc_T9", "normalized": [] }, { "id": "NCT02637453_exc_R5", "type": "Has_mood", "arg1_id": "NCT02637453_exc_T10", "arg2_id": "NCT02637453_exc_T11", "normalized": [] }, { "id": "NCT02637453_exc_R6", "type": "Has_value", "arg1_id": "NCT02637453_exc_T12", "arg2_id": "NCT02637453_exc_T13", "normalized": [] }, { "id": "NCT02637453_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT02637453_exc_T14", "arg2_id": "NCT02637453_exc_T15", "normalized": [] }, { "id": "NCT02637453_exc_R8", "type": "AND", "arg1_id": "NCT02637453_exc_T16", "arg2_id": "NCT02637453_exc_T17", "normalized": [] }, { "id": "NCT02637453_exc_R9", "type": "AND", "arg1_id": "NCT02637453_exc_T14", "arg2_id": "NCT02637453_exc_T16", "normalized": [] }, { "id": "NCT02637453_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT02637453_exc_T18", "arg2_id": "NCT02637453_exc_T19", "normalized": [] }, { "id": "NCT02637453_exc_R11", "type": "Has_value", "arg1_id": "NCT02637453_exc_T21", "arg2_id": "NCT02637453_exc_T22", "normalized": [] }, { "id": "NCT02637453_exc_R12", "type": "Has_value", "arg1_id": "NCT02637453_exc_T23", "arg2_id": "NCT02637453_exc_T24", "normalized": [] }, { "id": "NCT02637453_exc_R13", "type": "Has_qualifier", "arg1_id": "NCT02637453_exc_T26", "arg2_id": "NCT02637453_exc_T25", "normalized": [] }, { "id": "NCT02637453_exc_R14", "type": "Has_qualifier", "arg1_id": "NCT02637453_exc_T30", "arg2_id": "NCT02637453_exc_T29", "normalized": [] }, { "id": "NCT02637453_exc_R15", "type": "Has_value", "arg1_id": "NCT02637453_exc_T32", "arg2_id": "NCT02637453_exc_T33", "normalized": [] }, { "id": "NCT02637453_exc_R16", "type": "Has_value", "arg1_id": "NCT02637453_exc_T34", "arg2_id": "NCT02637453_exc_T35", "normalized": [] }, { "id": "NCT02637453_exc_R17", "type": "Subsumes", "arg1_id": "NCT02637453_exc_T30", "arg2_id": "NCT02637453_exc_T36", "normalized": [] }, { "id": "NCT02637453_exc_R18", "type": "AND", "arg1_id": "NCT02637453_exc_T37", "arg2_id": "NCT02637453_exc_T38", "normalized": [] } ]

[ { "id": "NCT02637453_inc_text", "type": "inclusion", "text": [ "No response to more than one antiarrhythmic drug, or unwilling to receive long-term drug treatment.\nCan provide informed consent form expressing willingness to participate in the study and comply with follow-up tests and evaluation procedures.\nAged 18-80 years.\n" ], "offsets": [ [ 0, 262 ] ] } ]

[ { "id": "NCT02637453_inc_T1", "type": "Drug", "text": [ "antiarrhythmic drug" ], "offsets": [ [ 29, 48 ] ], "normalized": [] }, { "id": "NCT02637453_inc_T2", "type": "Condition", "text": [ "response" ], "offsets": [ [ 3, 11 ] ], "normalized": [] }, { "id": "NCT02637453_inc_T3", "type": "Negation", "text": [ "No" ], "offsets": [ [ 0, 2 ] ], "normalized": [] }, { "id": "NCT02637453_inc_T4", "type": "Multiplier", "text": [ "more than one" ], "offsets": [ [ 15, 28 ] ], "normalized": [] }, { "id": "NCT02637453_inc_T7", "type": "Person", "text": [ "Aged" ], "offsets": [ [ 244, 248 ] ], "normalized": [] }, { "id": "NCT02637453_inc_T8", "type": "Value", "text": [ "18-80 years" ], "offsets": [ [ 249, 260 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02637453_inc_R1", "type": "Has_negation", "arg1_id": "NCT02637453_inc_T2", "arg2_id": "NCT02637453_inc_T3", "normalized": [] }, { "id": "NCT02637453_inc_R2", "type": "Has_multiplier", "arg1_id": "NCT02637453_inc_T1", "arg2_id": "NCT02637453_inc_T4", "normalized": [] }, { "id": "NCT02637453_inc_R3", "type": "AND", "arg1_id": "NCT02637453_inc_T2", "arg2_id": "NCT02637453_inc_T1", "normalized": [] }, { "id": "NCT02637453_inc_R4", "type": "Has_value", "arg1_id": "NCT02637453_inc_T7", "arg2_id": "NCT02637453_inc_T8", "normalized": [] } ]

[ { "id": "NCT02638935_exc_text", "type": "exclusion", "text": [ "Pregnant or lactating women \nWomen with breast implants on the same side as the lesion \nWomen that underwent local radiation or chemotherapy within the last 12 months \nWomen with history of breast cancer or breast surgery in the same quadrant \nLesions in or close to scar tissue (< 1cm) \nSkin lesions or lesions that have been biopsied previously \nLesion larger than 4 cm in the longest dimension \nNo lesion should be included when more than 50% of the lesion is further down than 4 cm beneath the skin level. \n \n" ], "offsets": [ [ 0, 522 ] ] } ]

[ { "id": "NCT02638935_exc_T1", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T2", "type": "Condition", "text": [ "lactating" ], "offsets": [ [ 12, 21 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T3", "type": "Person", "text": [ "women" ], "offsets": [ [ 22, 27 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T4", "type": "Person", "text": [ "Women" ], "offsets": [ [ 29, 34 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T5", "type": "Device", "text": [ "breast implants" ], "offsets": [ [ 40, 55 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T6", "type": "Qualifier", "text": [ "same side as the lesion" ], "offsets": [ [ 63, 86 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T7", "type": "Reference_point", "text": [ "the lesion" ], "offsets": [ [ 76, 86 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T8", "type": "Procedure", "text": [ "local radiation" ], "offsets": [ [ 109, 124 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T9", "type": "Procedure", "text": [ "chemotherapy" ], "offsets": [ [ 128, 140 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T10", "type": "Temporal", "text": [ "within the last 12 months" ], "offsets": [ [ 141, 166 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T11", "type": "Person", "text": [ "Women" ], "offsets": [ [ 88, 93 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T12", "type": "Person", "text": [ "Women" ], "offsets": [ [ 168, 173 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T13", "type": "Condition", "text": [ "breast cancer" ], "offsets": [ [ 190, 203 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T14", "type": "Condition", "text": [ "breast surgery" ], "offsets": [ [ 207, 221 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T15", "type": "Qualifier", "text": [ "same quadrant" ], "offsets": [ [ 229, 242 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T16", "type": "Condition", "text": [ "Lesions" ], "offsets": [ [ 244, 251 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T17", "type": "Qualifier", "text": [ "in or close to scar tissue" ], "offsets": [ [ 252, 278 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T18", "type": "Value", "text": [ "< 1cm" ], "offsets": [ [ 280, 285 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T19", "type": "Condition", "text": [ "Skin lesions" ], "offsets": [ [ 288, 300 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T20", "type": "Condition", "text": [ "lesions" ], "offsets": [ [ 304, 311 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T21", "type": "Procedure", "text": [ "biopsied" ], "offsets": [ [ 327, 335 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T22", "type": "Temporal", "text": [ "previously" ], "offsets": [ [ 336, 346 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T23", "type": "Condition", "text": [ "Lesion" ], "offsets": [ [ 348, 354 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T24", "type": "Value", "text": [ "larger than 4 cm" ], "offsets": [ [ 355, 371 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T25", "type": "Measurement", "text": [ "longest dimension" ], "offsets": [ [ 379, 396 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T26", "type": "Condition", "text": [ "lesion" ], "offsets": [ [ 401, 407 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T27", "type": "Multiplier", "text": [ "more than 50% of the lesion" ], "offsets": [ [ 432, 459 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T28", "type": "Value", "text": [ "further down than 4 cm" ], "offsets": [ [ 463, 485 ] ], "normalized": [] }, { "id": "NCT02638935_exc_T29", "type": "Measurement", "text": [ "beneath the skin level" ], "offsets": [ [ 486, 508 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02638935_exc_R1", "type": "Has_index", "arg1_id": "NCT02638935_exc_T6", "arg2_id": "NCT02638935_exc_T7", "normalized": [] }, { "id": "NCT02638935_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02638935_exc_T5", "arg2_id": "NCT02638935_exc_T6", "normalized": [] }, { "id": "NCT02638935_exc_R3", "type": "Has_temporal", "arg1_id": "NCT02638935_exc_T9", "arg2_id": "NCT02638935_exc_T10", "normalized": [] }, { "id": "NCT02638935_exc_R4", "type": "Has_temporal", "arg1_id": "NCT02638935_exc_T8", "arg2_id": "NCT02638935_exc_T10", "normalized": [] }, { "id": "NCT02638935_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT02638935_exc_T14", "arg2_id": "NCT02638935_exc_T15", "normalized": [] }, { "id": "NCT02638935_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02638935_exc_T13", "arg2_id": "NCT02638935_exc_T15", "normalized": [] }, { "id": "NCT02638935_exc_R7", "type": "Has_value", "arg1_id": "NCT02638935_exc_T17", "arg2_id": "NCT02638935_exc_T18", "normalized": [] }, { "id": "NCT02638935_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT02638935_exc_T16", "arg2_id": "NCT02638935_exc_T17", "normalized": [] }, { "id": "NCT02638935_exc_R9", "type": "Has_temporal", "arg1_id": "NCT02638935_exc_T21", "arg2_id": "NCT02638935_exc_T22", "normalized": [] }, { "id": "NCT02638935_exc_R10", "type": "AND", "arg1_id": "NCT02638935_exc_T23", "arg2_id": "NCT02638935_exc_T25", "normalized": [] }, { "id": "NCT02638935_exc_R11", "type": "Has_value", "arg1_id": "NCT02638935_exc_T25", "arg2_id": "NCT02638935_exc_T24", "normalized": [] }, { "id": "NCT02638935_exc_R12", "type": "Has_value", "arg1_id": "NCT02638935_exc_T29", "arg2_id": "NCT02638935_exc_T28", "normalized": [] }, { "id": "NCT02638935_exc_R13", "type": "Has_multiplier", "arg1_id": "NCT02638935_exc_T26", "arg2_id": "NCT02638935_exc_T27", "normalized": [] }, { "id": "NCT02638935_exc_R14", "type": "AND", "arg1_id": "NCT02638935_exc_T26", "arg2_id": "NCT02638935_exc_T29", "normalized": [] } ]

[ { "id": "NCT02638935_inc_text", "type": "inclusion", "text": [ "Female \nAge ≥18 years \nPatients with a lesion > 0.5 cm in largest diameter size, initially scored BI-RADS® 3, 4a, 4b or 4c in B-mode ultrasound \nInformed consent about histological examination (core cut biopsy (CCB), vacuum-assisted biopsy (VAB), fine needle aspiration (FNA) or surgery) has already been given in the course of clinical routine \nSigned informed consent of study participation \n" ], "offsets": [ [ 0, 394 ] ] } ]

[ { "id": "NCT02638935_inc_T1", "type": "Person", "text": [ "Female" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "NCT02638935_inc_T2", "type": "Value", "text": [ "≥18 years" ], "offsets": [ [ 12, 21 ] ], "normalized": [] }, { "id": "NCT02638935_inc_T3", "type": "Person", "text": [ "Age" ], "offsets": [ [ 8, 11 ] ], "normalized": [] }, { "id": "NCT02638935_inc_T4", "type": "Condition", "text": [ "lesion" ], "offsets": [ [ 39, 45 ] ], "normalized": [] }, { "id": "NCT02638935_inc_T5", "type": "Value", "text": [ "> 0.5 cm" ], "offsets": [ [ 46, 54 ] ], "normalized": [] }, { "id": "NCT02638935_inc_T6", "type": "Measurement", "text": [ "largest diameter size" ], "offsets": [ [ 58, 79 ] ], "normalized": [] }, { "id": "NCT02638935_inc_T7", "type": "Measurement", "text": [ "BI-RADS®" ], "offsets": [ [ 98, 106 ] ], "normalized": [] }, { "id": "NCT02638935_inc_T8", "type": "Value", "text": [ "3, 4a, 4b or 4c" ], "offsets": [ [ 107, 122 ] ], "normalized": [] }, { "id": "NCT02638935_inc_T9", "type": "Procedure", "text": [ "B-mode ultrasound" ], "offsets": [ [ 126, 143 ] ], "normalized": [] }, { "id": "NCT02638935_inc_T10", "type": "Procedure", "text": [ "histological examination" ], "offsets": [ [ 168, 192 ] ], "normalized": [] }, { "id": "NCT02638935_inc_T11", "type": "Procedure", "text": [ "core cut biopsy (CCB)" ], "offsets": [ [ 194, 215 ] ], "normalized": [] }, { "id": "NCT02638935_inc_T12", "type": "Procedure", "text": [ "vacuum-assisted biopsy (VAB)" ], "offsets": [ [ 217, 245 ] ], "normalized": [] }, { "id": "NCT02638935_inc_T13", "type": "Procedure", "text": [ "fine needle aspiration (FNA)" ], "offsets": [ [ 247, 275 ] ], "normalized": [] }, { "id": "NCT02638935_inc_T14", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 279, 286 ] ], "normalized": [] }, { "id": "NCT02638935_inc_T15", "type": "Scope", "text": [ "core cut biopsy (CCB), vacuum-assisted biopsy (VAB), fine needle aspiration (FNA) or surgery" ], "offsets": [ [ 194, 286 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02638935_inc_R1", "type": "Has_value", "arg1_id": "NCT02638935_inc_T3", "arg2_id": "NCT02638935_inc_T2", "normalized": [] }, { "id": "NCT02638935_inc_R2", "type": "Has_value", "arg1_id": "NCT02638935_inc_T6", "arg2_id": "NCT02638935_inc_T5", "normalized": [] }, { "id": "NCT02638935_inc_R3", "type": "Has_value", "arg1_id": "NCT02638935_inc_T7", "arg2_id": "NCT02638935_inc_T8", "normalized": [] }, { "id": "NCT02638935_inc_R4", "type": "AND", "arg1_id": "NCT02638935_inc_T9", "arg2_id": "NCT02638935_inc_T7", "normalized": [] }, { "id": "NCT02638935_inc_R5", "type": "AND", "arg1_id": "NCT02638935_inc_T4", "arg2_id": "NCT02638935_inc_T6", "normalized": [] }, { "id": "NCT02638935_inc_R6", "type": "AND", "arg1_id": "NCT02638935_inc_T4", "arg2_id": "NCT02638935_inc_T9", "normalized": [] }, { "id": "NCT02638935_inc_R7", "type": "Subsumes", "arg1_id": "NCT02638935_inc_T10", "arg2_id": "NCT02638935_inc_T15", "normalized": [] } ]

[ { "id": "NCT02643381_exc_text", "type": "exclusion", "text": [ "Children (<18 years old).\nWomen who are known to be pregnant.\nAny patient who has been previously randomized in the EvK Trial.\nPatients who require endotracheal intubation without sedative medication. For example, patients in full cardiac arrest.\nPatients with a known allergy to ketamine or etomidate.\nAny individual wearing a MedAlert bracelet indicating that he/she has formally opted out of the EvK Trial.\n" ], "offsets": [ [ 0, 410 ] ] } ]

[ { "id": "NCT02643381_exc_T1", "type": "Person", "text": [ "Children" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT02643381_exc_T2", "type": "Value", "text": [ "<18 years" ], "offsets": [ [ 10, 19 ] ], "normalized": [] }, { "id": "NCT02643381_exc_T3", "type": "Person", "text": [ "old" ], "offsets": [ [ 20, 23 ] ], "normalized": [] }, { "id": "NCT02643381_exc_T4", "type": "Scope", "text": [ "<18 years old" ], "offsets": [ [ 10, 23 ] ], "normalized": [] }, { "id": "NCT02643381_exc_T5", "type": "Person", "text": [ "Women" ], "offsets": [ [ 26, 31 ] ], "normalized": [] }, { "id": "NCT02643381_exc_T6", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 52, 60 ] ], "normalized": [] }, { "id": "NCT02643381_exc_T7", "type": "Procedure", "text": [ "randomized" ], "offsets": [ [ 98, 108 ] ], "normalized": [] }, { "id": "NCT02643381_exc_T8", "type": "Temporal", "text": [ "previously" ], "offsets": [ [ 87, 97 ] ], "normalized": [] }, { "id": "NCT02643381_exc_T9", "type": "Procedure", "text": [ "endotracheal intubation" ], "offsets": [ [ 148, 171 ] ], "normalized": [] }, { "id": "NCT02643381_exc_T10", "type": "Observation", "text": [ "require" ], "offsets": [ [ 140, 147 ] ], "normalized": [] }, { "id": "NCT02643381_exc_T11", "type": "Drug", "text": [ "sedative medication" ], "offsets": [ [ 180, 199 ] ], "normalized": [] }, { "id": "NCT02643381_exc_T12", "type": "Negation", "text": [ "without" ], "offsets": [ [ 172, 179 ] ], "normalized": [] }, { "id": "NCT02643381_exc_T13", "type": "Condition", "text": [ "full cardiac arrest" ], "offsets": [ [ 226, 245 ] ], "normalized": [] }, { "id": "NCT02643381_exc_T14", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 269, 276 ] ], "normalized": [] }, { "id": "NCT02643381_exc_T15", "type": "Drug", "text": [ "ketamine" ], "offsets": [ [ 280, 288 ] ], "normalized": [] }, { "id": "NCT02643381_exc_T16", "type": "Drug", "text": [ "etomidate" ], "offsets": [ [ 292, 301 ] ], "normalized": [] }, { "id": "NCT02643381_exc_T17", "type": "Scope", "text": [ "ketamine or etomidate" ], "offsets": [ [ 280, 301 ] ], "normalized": [] }, { "id": "NCT02643381_exc_T18", "type": "Condition", "text": [ "Any individual wearing a MedAlert bracelet indicating that he/she has formally opted out of the EvK Trial" ], "offsets": [ [ 303, 408 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02643381_exc_R1", "type": "Has_value", "arg1_id": "NCT02643381_exc_T3", "arg2_id": "NCT02643381_exc_T2", "normalized": [] }, { "id": "NCT02643381_exc_R2", "type": "Subsumes", "arg1_id": "NCT02643381_exc_T1", "arg2_id": "NCT02643381_exc_T4", "normalized": [] }, { "id": "NCT02643381_exc_R3", "type": "Has_temporal", "arg1_id": "NCT02643381_exc_T7", "arg2_id": "NCT02643381_exc_T8", "normalized": [] }, { "id": "NCT02643381_exc_R5", "type": "Has_negation", "arg1_id": "NCT02643381_exc_T11", "arg2_id": "NCT02643381_exc_T12", "normalized": [] }, { "id": "NCT02643381_exc_R6", "type": "AND", "arg1_id": "NCT02643381_exc_T9", "arg2_id": "NCT02643381_exc_T11", "normalized": [] }, { "id": "NCT02643381_exc_R7", "type": "Has_scope", "arg1_id": "NCT02643381_exc_T14", "arg2_id": "NCT02643381_exc_T17", "normalized": [] } ]

[ { "id": "NCT02643381_inc_text", "type": "inclusion", "text": [ "Adult patient (male or female) requiring emergency endotracheal intubation.\n" ], "offsets": [ [ 0, 76 ] ] } ]

[ { "id": "NCT02643381_inc_T1", "type": "Person", "text": [ "Adult" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT02643381_inc_T2", "type": "Person", "text": [ "male" ], "offsets": [ [ 15, 19 ] ], "normalized": [] }, { "id": "NCT02643381_inc_T3", "type": "Person", "text": [ "female" ], "offsets": [ [ 23, 29 ] ], "normalized": [] }, { "id": "NCT02643381_inc_T4", "type": "Procedure", "text": [ "emergency endotracheal intubation" ], "offsets": [ [ 41, 74 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "NCT02644629_exc_text", "type": "exclusion", "text": [ "Active or past psychotic disorder, including a history of psychotic affective state\nMental Retardation or Autistic Spectrum Disorder\nProminent personality disorder\nCardiac or neurologic active medical condition, including past CVA/TIA (Cardiovascular Accident/Transient Ischemic Attack) or any other unstable medical condition.\nChronic nasal congestion\nActive or recent drug or alcohol abuse\nSubstantial suicidality in a patient requiring admission but refuses to do so, and signs an \"against medical advice\" release form as part of clinical evaluation, and does not answer the terms for involuntary admission.\n" ], "offsets": [ [ 0, 611 ] ] } ]

[ { "id": "NCT02644629_exc_T1", "type": "Condition", "text": [ "psychotic disorder" ], "offsets": [ [ 15, 33 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T2", "type": "Condition", "text": [ "psychotic affective state" ], "offsets": [ [ 58, 83 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T3", "type": "Temporal", "text": [ "Active" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T4", "type": "Temporal", "text": [ "past" ], "offsets": [ [ 10, 14 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T5", "type": "Scope", "text": [ "Active or past" ], "offsets": [ [ 0, 14 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T6", "type": "Condition", "text": [ "Mental Retardation" ], "offsets": [ [ 84, 102 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T7", "type": "Condition", "text": [ "Autistic Spectrum Disorder" ], "offsets": [ [ 106, 132 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T8", "type": "Condition", "text": [ "Prominent personality disorder" ], "offsets": [ [ 133, 163 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T9", "type": "Condition", "text": [ "neurologic active medical condition" ], "offsets": [ [ 175, 210 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T10", "type": "Condition", "text": [ "diac or", "ive medical condition, i" ], "offsets": [ [ 167, 174 ], [ 189, 213 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T11", "type": "Condition", "text": [ "CVA" ], "offsets": [ [ 227, 230 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T12", "type": "Condition", "text": [ "TIA" ], "offsets": [ [ 231, 234 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T13", "type": "Temporal", "text": [ "past" ], "offsets": [ [ 222, 226 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T14", "type": "Condition", "text": [ "Cardiovascular Accident" ], "offsets": [ [ 236, 259 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T15", "type": "Condition", "text": [ "Transient Ischemic Attack" ], "offsets": [ [ 260, 285 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T16", "type": "Scope", "text": [ "CVA/TIA (Cardiovascular Accident/Transient Ischemic Attack)" ], "offsets": [ [ 227, 286 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T17", "type": "Qualifier", "text": [ "unstable" ], "offsets": [ [ 300, 308 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T18", "type": "Condition", "text": [ "medical condition" ], "offsets": [ [ 309, 326 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T19", "type": "Scope", "text": [ "Cardiac or neurologic active medical condition" ], "offsets": [ [ 164, 210 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T20", "type": "Scope", "text": [ "past CVA/TIA (Cardiovascular Accident/Transient Ischemic Attack) or any other unstable medical condition" ], "offsets": [ [ 222, 326 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T21", "type": "Condition", "text": [ "nasal congestion" ], "offsets": [ [ 336, 352 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T22", "type": "Temporal", "text": [ "Chronic" ], "offsets": [ [ 328, 335 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T23", "type": "Condition", "text": [ "alcohol abuse" ], "offsets": [ [ 378, 391 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T24", "type": "Temporal", "text": [ "recent" ], "offsets": [ [ 363, 369 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T25", "type": "Temporal", "text": [ "Active" ], "offsets": [ [ 353, 359 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T26", "type": "Condition", "text": [ "or a", "\nSub" ], "offsets": [ [ 375, 379 ], [ 391, 395 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T27", "type": "Scope", "text": [ "drug or alcohol abuse" ], "offsets": [ [ 370, 391 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T28", "type": "Scope", "text": [ "Active or recent" ], "offsets": [ [ 353, 369 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T29", "type": "Condition", "text": [ "suicidality" ], "offsets": [ [ 404, 415 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T30", "type": "Qualifier", "text": [ "Substantial" ], "offsets": [ [ 392, 403 ] ], "normalized": [] }, { "id": "NCT02644629_exc_T31", "type": "Procedure", "text": [ "admission" ], "offsets": [ [ 439, 448 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02644629_exc_R1", "type": "Has_scope", "arg1_id": "NCT02644629_exc_T1", "arg2_id": "NCT02644629_exc_T5", "normalized": [] }, { "id": "NCT02644629_exc_R2", "type": "Subsumes", "arg1_id": "NCT02644629_exc_T1", "arg2_id": "NCT02644629_exc_T2", "normalized": [] }, { "id": "NCT02644629_exc_R3", "type": "Subsumes", "arg1_id": "NCT02644629_exc_T11", "arg2_id": "NCT02644629_exc_T14", "normalized": [] }, { "id": "NCT02644629_exc_R4", "type": "Subsumes", "arg1_id": "NCT02644629_exc_T12", "arg2_id": "NCT02644629_exc_T15", "normalized": [] }, { "id": "NCT02644629_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02644629_exc_T16", "arg2_id": "NCT02644629_exc_T13", "normalized": [] }, { "id": "NCT02644629_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02644629_exc_T18", "arg2_id": "NCT02644629_exc_T17", "normalized": [] }, { "id": "NCT02644629_exc_R7", "type": "Subsumes", "arg1_id": "NCT02644629_exc_T19", "arg2_id": "NCT02644629_exc_T20", "normalized": [] }, { "id": "NCT02644629_exc_R8", "type": "Has_temporal", "arg1_id": "NCT02644629_exc_T21", "arg2_id": "NCT02644629_exc_T22", "normalized": [] }, { "id": "NCT02644629_exc_R9", "type": "Has_scope", "arg1_id": "NCT02644629_exc_T27", "arg2_id": "NCT02644629_exc_T28", "normalized": [] }, { "id": "NCT02644629_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT02644629_exc_T29", "arg2_id": "NCT02644629_exc_T30", "normalized": [] }, { "id": "NCT02644629_exc_R11", "type": "AND", "arg1_id": "NCT02644629_exc_T29", "arg2_id": "NCT02644629_exc_T31", "normalized": [] } ]

[ { "id": "NCT02644629_inc_text", "type": "inclusion", "text": [ "Age 18-65\nDiagnosis of MDD (Major Depressive Disorder), made or affirmed by a senior psychiatrist in Shalvata\nMADRS score > 20\nTreated with conventional anti-depressant, administered within a formal psychiatric clinic or by a certified psychiatrist.\n" ], "offsets": [ [ 0, 250 ] ] } ]

[ { "id": "NCT02644629_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02644629_inc_T2", "type": "Value", "text": [ "18-65" ], "offsets": [ [ 4, 9 ] ], "normalized": [] }, { "id": "NCT02644629_inc_T3", "type": "Condition", "text": [ "MDD" ], "offsets": [ [ 23, 26 ] ], "normalized": [] }, { "id": "NCT02644629_inc_T4", "type": "Condition", "text": [ "Major Depressive Disorder" ], "offsets": [ [ 28, 53 ] ], "normalized": [] }, { "id": "NCT02644629_inc_T5", "type": "Measurement", "text": [ "MADRS score" ], "offsets": [ [ 110, 121 ] ], "normalized": [] }, { "id": "NCT02644629_inc_T6", "type": "Value", "text": [ "> 20" ], "offsets": [ [ 122, 126 ] ], "normalized": [] }, { "id": "NCT02644629_inc_T7", "type": "Drug", "text": [ "conventional anti-depressant" ], "offsets": [ [ 140, 168 ] ], "normalized": [] }, { "id": "NCT02644629_inc_T8", "type": "Procedure", "text": [ "Treated" ], "offsets": [ [ 127, 134 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02644629_inc_R1", "type": "Has_value", "arg1_id": "NCT02644629_inc_T1", "arg2_id": "NCT02644629_inc_T2", "normalized": [] }, { "id": "NCT02644629_inc_R2", "type": "Subsumes", "arg1_id": "NCT02644629_inc_T3", "arg2_id": "NCT02644629_inc_T4", "normalized": [] }, { "id": "NCT02644629_inc_R3", "type": "Has_value", "arg1_id": "NCT02644629_inc_T5", "arg2_id": "NCT02644629_inc_T6", "normalized": [] }, { "id": "NCT02644629_inc_R4", "type": "AND", "arg1_id": "NCT02644629_inc_T8", "arg2_id": "NCT02644629_inc_T7", "normalized": [] } ]

[ { "id": "NCT02645474_exc_text", "type": "exclusion", "text": [ "patients' refusal\ncontraindication to regional anaesthesia (coagulopathies, concurrent anticoagulant therapy, allergy to local anaesthetics, infection at puncture site)\n" ], "offsets": [ [ 0, 169 ] ] } ]

[ { "id": "NCT02645474_exc_T2", "type": "Condition", "text": [ "contraindication" ], "offsets": [ [ 18, 34 ] ], "normalized": [] }, { "id": "NCT02645474_exc_T3", "type": "Procedure", "text": [ "regional anaesthesia (" ], "offsets": [ [ 38, 60 ] ], "normalized": [] }, { "id": "NCT02645474_exc_T4", "type": "Condition", "text": [ "coagulopathies" ], "offsets": [ [ 60, 74 ] ], "normalized": [] }, { "id": "NCT02645474_exc_T5", "type": "Drug", "text": [ "anticoagulant therapy" ], "offsets": [ [ 87, 108 ] ], "normalized": [] }, { "id": "NCT02645474_exc_T6", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 110, 117 ] ], "normalized": [] }, { "id": "NCT02645474_exc_T7", "type": "Procedure", "text": [ "local anaesthetics" ], "offsets": [ [ 121, 139 ] ], "normalized": [] }, { "id": "NCT02645474_exc_T8", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 141, 150 ] ], "normalized": [] }, { "id": "NCT02645474_exc_T9", "type": "Qualifier", "text": [ "puncture site" ], "offsets": [ [ 154, 167 ] ], "normalized": [] }, { "id": "NCT02645474_exc_T10", "type": "Scope", "text": [ "coagulopathies, concurrent anticoagulant therapy, allergy to local anaesthetics, infection at puncture site" ], "offsets": [ [ 60, 167 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02645474_exc_R1", "type": "AND", "arg1_id": "NCT02645474_exc_T2", "arg2_id": "NCT02645474_exc_T3", "normalized": [] }, { "id": "NCT02645474_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02645474_exc_T8", "arg2_id": "NCT02645474_exc_T9", "normalized": [] }, { "id": "NCT02645474_exc_R3", "type": "AND", "arg1_id": "NCT02645474_exc_T6", "arg2_id": "NCT02645474_exc_T7", "normalized": [] }, { "id": "NCT02645474_exc_R4", "type": "Subsumes", "arg1_id": "NCT02645474_exc_T2", "arg2_id": "NCT02645474_exc_T10", "normalized": [] } ]

[ { "id": "NCT02645474_inc_text", "type": "inclusion", "text": [ "adult patients\nASA class 1 to 3 patients\npatients scheduled for elective breast mastectomy or quadrantectomy\n" ], "offsets": [ [ 0, 109 ] ] } ]

[ { "id": "NCT02645474_inc_T1", "type": "Person", "text": [ "adult" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT02645474_inc_T2", "type": "Measurement", "text": [ "ASA class" ], "offsets": [ [ 15, 24 ] ], "normalized": [] }, { "id": "NCT02645474_inc_T3", "type": "Value", "text": [ "1 to 3" ], "offsets": [ [ 25, 31 ] ], "normalized": [] }, { "id": "NCT02645474_inc_T4", "type": "Qualifier", "text": [ "elective" ], "offsets": [ [ 64, 72 ] ], "normalized": [] }, { "id": "NCT02645474_inc_T5", "type": "Procedure", "text": [ "mastectomy" ], "offsets": [ [ 80, 90 ] ], "normalized": [] }, { "id": "NCT02645474_inc_T6", "type": "Procedure", "text": [ "east m", "adrantectomy" ], "offsets": [ [ 75, 81 ], [ 96, 108 ] ], "normalized": [] }, { "id": "NCT02645474_inc_T7", "type": "Scope", "text": [ "breast mastectomy or quadrantectomy" ], "offsets": [ [ 73, 108 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02645474_inc_R1", "type": "Has_value", "arg1_id": "NCT02645474_inc_T2", "arg2_id": "NCT02645474_inc_T3", "normalized": [] }, { "id": "NCT02645474_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02645474_inc_T7", "arg2_id": "NCT02645474_inc_T4", "normalized": [] } ]

[ { "id": "NCT02647788_exc_text", "type": "exclusion", "text": [ "ASA> 3;\nCoagulopathy;\nRenal disease,\nLiver disease,\nHistory of recent gastro-intestinal bleeding\nPregnancy.\nDiagnosis of chronic pain currently taking opioid pain medication or with a history of drug abuse.\nPatients with a self-described allergy to ASA, acetaminophen, NSAIDS and codeine.\nAll patients receiving a brachial plexus block for anesthesia and/or analgesia\n" ], "offsets": [ [ 0, 368 ] ] } ]

[ { "id": "NCT02647788_exc_T1", "type": "Measurement", "text": [ "ASA" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02647788_exc_T2", "type": "Value", "text": [ "> 3" ], "offsets": [ [ 3, 6 ] ], "normalized": [] }, { "id": "NCT02647788_exc_T3", "type": "Condition", "text": [ "Coagulopathy" ], "offsets": [ [ 8, 20 ] ], "normalized": [] }, { "id": "NCT02647788_exc_T4", "type": "Condition", "text": [ "Renal disease" ], "offsets": [ [ 22, 35 ] ], "normalized": [] }, { "id": "NCT02647788_exc_T5", "type": "Condition", "text": [ "Liver disease" ], "offsets": [ [ 37, 50 ] ], "normalized": [] }, { "id": "NCT02647788_exc_T6", "type": "Condition", "text": [ "gastro-intestinal bleeding" ], "offsets": [ [ 70, 96 ] ], "normalized": [] }, { "id": "NCT02647788_exc_T7", "type": "Temporal", "text": [ "recent" ], "offsets": [ [ 63, 69 ] ], "normalized": [] }, { "id": "NCT02647788_exc_T8", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 97, 106 ] ], "normalized": [] }, { "id": "NCT02647788_exc_T9", "type": "Condition", "text": [ "chronic pain" ], "offsets": [ [ 121, 133 ] ], "normalized": [] }, { "id": "NCT02647788_exc_T10", "type": "Drug", "text": [ "opioid pain medication" ], "offsets": [ [ 151, 173 ] ], "normalized": [] }, { "id": "NCT02647788_exc_T11", "type": "Observation", "text": [ "history of" ], "offsets": [ [ 184, 194 ] ], "normalized": [] }, { "id": "NCT02647788_exc_T12", "type": "Condition", "text": [ "drug abuse" ], "offsets": [ [ 195, 205 ] ], "normalized": [] }, { "id": "NCT02647788_exc_T13", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 238, 245 ] ], "normalized": [] }, { "id": "NCT02647788_exc_T14", "type": "Drug", "text": [ "ASA" ], "offsets": [ [ 249, 252 ] ], "normalized": [] }, { "id": "NCT02647788_exc_T15", "type": "Drug", "text": [ "acetaminophen" ], "offsets": [ [ 254, 267 ] ], "normalized": [] }, { "id": "NCT02647788_exc_T16", "type": "Drug", "text": [ "NSAIDS" ], "offsets": [ [ 269, 275 ] ], "normalized": [] }, { "id": "NCT02647788_exc_T17", "type": "Drug", "text": [ "codeine" ], "offsets": [ [ 280, 287 ] ], "normalized": [] }, { "id": "NCT02647788_exc_T18", "type": "Scope", "text": [ "ASA, acetaminophen, NSAIDS and codeine" ], "offsets": [ [ 249, 287 ] ], "normalized": [] }, { "id": "NCT02647788_exc_T19", "type": "Procedure", "text": [ "brachial plexus block" ], "offsets": [ [ 314, 335 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02647788_exc_R1", "type": "Has_value", "arg1_id": "NCT02647788_exc_T1", "arg2_id": "NCT02647788_exc_T2", "normalized": [] }, { "id": "NCT02647788_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02647788_exc_T6", "arg2_id": "NCT02647788_exc_T7", "normalized": [] }, { "id": "NCT02647788_exc_R3", "type": "Has_temporal", "arg1_id": "NCT02647788_exc_T12", "arg2_id": "NCT02647788_exc_T11", "normalized": [] }, { "id": "NCT02647788_exc_R4", "type": "AND", "arg1_id": "NCT02647788_exc_T9", "arg2_id": "NCT02647788_exc_T10", "normalized": [] }, { "id": "NCT02647788_exc_R5", "type": "Has_scope", "arg1_id": "NCT02647788_exc_T13", "arg2_id": "NCT02647788_exc_T18", "normalized": [] } ]

[ { "id": "NCT02647788_inc_text", "type": "inclusion", "text": [ "Patients undergoing ambulatory hand surgery for carpal tunnel and trigger finger, under local anesthesia with or without sedation.\n" ], "offsets": [ [ 0, 131 ] ] } ]

[ { "id": "NCT02647788_inc_T2", "type": "Qualifier", "text": [ "ambulatory" ], "offsets": [ [ 20, 30 ] ], "normalized": [] }, { "id": "NCT02647788_inc_T1", "type": "Procedure", "text": [ "hand surgery" ], "offsets": [ [ 31, 43 ] ], "normalized": [] }, { "id": "NCT02647788_inc_T3", "type": "Condition", "text": [ "carpal tunnel" ], "offsets": [ [ 48, 61 ] ], "normalized": [] }, { "id": "NCT02647788_inc_T4", "type": "Condition", "text": [ "trigger finger" ], "offsets": [ [ 66, 80 ] ], "normalized": [] }, { "id": "NCT02647788_inc_T5", "type": "Scope", "text": [ "carpal tunnel and trigger finger" ], "offsets": [ [ 48, 80 ] ], "normalized": [] }, { "id": "NCT02647788_inc_T6", "type": "Procedure", "text": [ "local anesthesia" ], "offsets": [ [ 88, 104 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02647788_inc_R1", "type": "Has_scope", "arg1_id": "NCT02647788_inc_T1", "arg2_id": "NCT02647788_inc_T5", "normalized": [] }, { "id": "NCT02647788_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02647788_inc_T1", "arg2_id": "NCT02647788_inc_T2", "normalized": [] }, { "id": "NCT02647788_inc_R3", "type": "AND", "arg1_id": "NCT02647788_inc_T1", "arg2_id": "NCT02647788_inc_T6", "normalized": [] } ]

[ { "id": "NCT02649114_exc_text", "type": "exclusion", "text": [ "current suicidal risk \ncurrent psychosis \nongoing trauma (e.g. current involvement in an abusive relationship). \n \n" ], "offsets": [ [ 0, 124 ] ] } ]

[ { "id": "NCT02649114_exc_T1", "type": "Condition", "text": [ "suicidal risk" ], "offsets": [ [ 8, 21 ] ], "normalized": [] }, { "id": "NCT02649114_exc_T2", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "NCT02649114_exc_T3", "type": "Condition", "text": [ "psychosis" ], "offsets": [ [ 31, 40 ] ], "normalized": [] }, { "id": "NCT02649114_exc_T4", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 23, 30 ] ], "normalized": [] }, { "id": "NCT02649114_exc_T5", "type": "Condition", "text": [ "trauma" ], "offsets": [ [ 50, 56 ] ], "normalized": [] }, { "id": "NCT02649114_exc_T6", "type": "Temporal", "text": [ "ongoing" ], "offsets": [ [ 42, 49 ] ], "normalized": [] }, { "id": "NCT02649114_exc_T7", "type": "Condition", "text": [ "involvement in an abusive relationship" ], "offsets": [ [ 71, 109 ] ], "normalized": [] }, { "id": "NCT02649114_exc_T8", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 63, 70 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02649114_exc_R1", "type": "Has_temporal", "arg1_id": "NCT02649114_exc_T1", "arg2_id": "NCT02649114_exc_T2", "normalized": [] }, { "id": "NCT02649114_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02649114_exc_T3", "arg2_id": "NCT02649114_exc_T4", "normalized": [] }, { "id": "NCT02649114_exc_R3", "type": "Has_temporal", "arg1_id": "NCT02649114_exc_T5", "arg2_id": "NCT02649114_exc_T6", "normalized": [] }, { "id": "NCT02649114_exc_R4", "type": "Has_temporal", "arg1_id": "NCT02649114_exc_T7", "arg2_id": "NCT02649114_exc_T8", "normalized": [] }, { "id": "NCT02649114_exc_R5", "type": "Subsumes", "arg1_id": "NCT02649114_exc_T5", "arg2_id": "NCT02649114_exc_T7", "normalized": [] } ]

[ { "id": "NCT02649114_inc_text", "type": "inclusion", "text": [ "satisfying DSM-V criteria for ED and for half of the patients in addition \nhave a history of childhood trauma. \n" ], "offsets": [ [ 0, 112 ] ] } ]

[ { "id": "NCT02649114_inc_T1", "type": "Measurement", "text": [ "DSM-V criteria" ], "offsets": [ [ 11, 25 ] ], "normalized": [] }, { "id": "NCT02649114_inc_T2", "type": "Value", "text": [ "satisfying" ], "offsets": [ [ 0, 10 ] ], "normalized": [] }, { "id": "NCT02649114_inc_T3", "type": "Condition", "text": [ "ED" ], "offsets": [ [ 30, 32 ] ], "normalized": [] }, { "id": "NCT02649114_inc_T5", "type": "Condition", "text": [ "childhood trauma" ], "offsets": [ [ 93, 109 ] ], "normalized": [] }, { "id": "NCT02649114_inc_T6", "type": "Observation", "text": [ "history" ], "offsets": [ [ 82, 89 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02649114_inc_R1", "type": "Has_value", "arg1_id": "NCT02649114_inc_T1", "arg2_id": "NCT02649114_inc_T2", "normalized": [] }, { "id": "NCT02649114_inc_R2", "type": "AND", "arg1_id": "NCT02649114_inc_T3", "arg2_id": "NCT02649114_inc_T1", "normalized": [] }, { "id": "NCT02649114_inc_R3", "type": "Has_temporal", "arg1_id": "NCT02649114_inc_T5", "arg2_id": "NCT02649114_inc_T6", "normalized": [] } ]

[ { "id": "NCT02650024_exc_text", "type": "exclusion", "text": [ "Amiodarone\nP-glycoprotein (P-gp) inducers (e.g., rifampin, St. John's wort)\nLiver biopsy at any time showing mHAI stage 4 or higher fibrosis OR\nFibroScan within 12 months demonstrating liver stiffness of =9.5 kilo Pascal or\nAST to platelet ratio index (APRI) =2.0 and Fibrosis-4 (FIB-4) =3.25\nNOTE: If APRI and FIB-4 are discordant one of the other forms of fibrosis staging must be used.\nKnown allergy/sensitivity or any hypersensitivity to components of study drugs or their formulation.\nHemochromatosis\nAlpha-1 antitrypsin deficiency\nWilson's disease\nAutoimmune hepatitis\nAlcoholic liver disease\nDrug-related liver disease\nSevere NC confounding conditions (stroke, head injury, or developmental learning disability).\nRegular use of anti-inflammatory drugs.\nCurrent or recent treatment with pegylated interferon (PEG-IFN).\nOther active inflammatory process (major infection, malignancy, rheumatoid arthritis/autoimmune disorder) within the prior 28 days.\nContraindications to magnetic resonance imaging (MRI).\nBleeding diathesis, thrombocytopenia, or use of anticoagulants that would contraindicate lumbar puncture.\nUncontrolled or active depression or other psychiatric disorder that in the opinion of the site investigator might preclude adherence to study requirements or impact NC functioning and assessments.\nActive drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements.\nPresence of active or acute AIDS-defining opportunistic infections within 12 weeks prior to study entry.\n" ], "offsets": [ [ 0, 1563 ] ] } ]

[ { "id": "NCT02650024_exc_T1", "type": "Drug", "text": [ "Amiodarone" ], "offsets": [ [ 0, 10 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T2", "type": "Drug", "text": [ "P-glycoprotein (P-gp) inducers" ], "offsets": [ [ 11, 41 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T3", "type": "Drug", "text": [ "rifampin" ], "offsets": [ [ 49, 57 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T4", "type": "Drug", "text": [ "St. John's wort" ], "offsets": [ [ 59, 74 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T5", "type": "Scope", "text": [ "rifampin, St. John's wort" ], "offsets": [ [ 49, 74 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T6", "type": "Procedure", "text": [ "Liver biopsy" ], "offsets": [ [ 76, 88 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T7", "type": "Measurement", "text": [ "mHAI stage" ], "offsets": [ [ 109, 119 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T8", "type": "Value", "text": [ "4 or higher" ], "offsets": [ [ 120, 131 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T9", "type": "Temporal", "text": [ "any time" ], "offsets": [ [ 92, 100 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T10", "type": "Procedure", "text": [ "FibroScan" ], "offsets": [ [ 144, 153 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T11", "type": "Temporal", "text": [ "within 12 months" ], "offsets": [ [ 154, 170 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T12", "type": "Measurement", "text": [ "liver stiffness" ], "offsets": [ [ 185, 200 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T13", "type": "Value", "text": [ "=9.5 kilo Pascal" ], "offsets": [ [ 204, 220 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T14", "type": "Measurement", "text": [ "AST to platelet ratio index (APRI)" ], "offsets": [ [ 224, 258 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T15", "type": "Value", "text": [ "=2.0" ], "offsets": [ [ 259, 263 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T16", "type": "Measurement", "text": [ "Fibrosis-4 (FIB-4)" ], "offsets": [ [ 268, 286 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T17", "type": "Value", "text": [ "=3.25" ], "offsets": [ [ 287, 292 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T19", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 395, 402 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T20", "type": "Condition", "text": [ "sensitivity" ], "offsets": [ [ 403, 414 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T21", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 422, 438 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T22", "type": "Drug", "text": [ "components of study drugs" ], "offsets": [ [ 442, 467 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T23", "type": "Scope", "text": [ "allergy/sensitivity or any hypersensitivity" ], "offsets": [ [ 395, 438 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T24", "type": "Condition", "text": [ "Hemochromatosis" ], "offsets": [ [ 490, 505 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T25", "type": "Condition", "text": [ "Alpha-1 antitrypsin deficiency" ], "offsets": [ [ 506, 536 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T26", "type": "Condition", "text": [ "Wilson's disease" ], "offsets": [ [ 537, 553 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T27", "type": "Condition", "text": [ "Autoimmune hepatitis" ], "offsets": [ [ 554, 574 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T28", "type": "Condition", "text": [ "Alcoholic liver disease" ], "offsets": [ [ 575, 598 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T29", "type": "Condition", "text": [ "Drug-related liver disease" ], "offsets": [ [ 599, 625 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T30", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 660, 666 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T31", "type": "Condition", "text": [ "head injury" ], "offsets": [ [ 668, 679 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T32", "type": "Condition", "text": [ "developmental learning disability" ], "offsets": [ [ 684, 717 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T33", "type": "Condition", "text": [ "NC confounding conditions" ], "offsets": [ [ 633, 658 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T34", "type": "Scope", "text": [ "stroke, head injury, or developmental learning disability" ], "offsets": [ [ 660, 717 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T35", "type": "Drug", "text": [ "anti-inflammatory drugs" ], "offsets": [ [ 735, 758 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T36", "type": "Drug", "text": [ "pegylated interferon" ], "offsets": [ [ 793, 813 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T37", "type": "Drug", "text": [ "PEG-IFN" ], "offsets": [ [ 815, 822 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T38", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 778, 787 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T39", "type": "Temporal", "text": [ "recent" ], "offsets": [ [ 771, 777 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T40", "type": "Temporal", "text": [ "Current" ], "offsets": [ [ 760, 767 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T41", "type": "Scope", "text": [ "Current or recent" ], "offsets": [ [ 760, 777 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T42", "type": "Condition", "text": [ "active inflammatory process" ], "offsets": [ [ 831, 858 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T43", "type": "Qualifier", "text": [ "Other" ], "offsets": [ [ 825, 830 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T44", "type": "Condition", "text": [ "major infection" ], "offsets": [ [ 860, 875 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T45", "type": "Condition", "text": [ "malignancy" ], "offsets": [ [ 877, 887 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T46", "type": "Condition", "text": [ "rheumatoid arthritis" ], "offsets": [ [ 889, 909 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T47", "type": "Condition", "text": [ "autoimmune disorder" ], "offsets": [ [ 910, 929 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T48", "type": "Scope", "text": [ "major infection, malignancy, rheumatoid arthritis/autoimmune disorder" ], "offsets": [ [ 860, 929 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T49", "type": "Temporal", "text": [ "within the prior 28 days" ], "offsets": [ [ 931, 955 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T50", "type": "Procedure", "text": [ "magnetic resonance imaging (MRI)" ], "offsets": [ [ 978, 1010 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T51", "type": "Condition", "text": [ "Contraindications" ], "offsets": [ [ 957, 974 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T52", "type": "Condition", "text": [ "Bleeding diathesis" ], "offsets": [ [ 1012, 1030 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T53", "type": "Condition", "text": [ "thrombocytopenia" ], "offsets": [ [ 1032, 1048 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T54", "type": "Drug", "text": [ "anticoagulants" ], "offsets": [ [ 1060, 1074 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T55", "type": "Condition", "text": [ "contraindicate" ], "offsets": [ [ 1086, 1100 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T56", "type": "Procedure", "text": [ "lumbar puncture" ], "offsets": [ [ 1101, 1116 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T57", "type": "Temporal", "text": [ "active" ], "offsets": [ [ 1134, 1140 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T58", "type": "Qualifier", "text": [ "Uncontrolled" ], "offsets": [ [ 1118, 1130 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T59", "type": "Condition", "text": [ "depression" ], "offsets": [ [ 1141, 1151 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T60", "type": "Scope", "text": [ "Uncontrolled or active" ], "offsets": [ [ 1118, 1140 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T61", "type": "Condition", "text": [ "psychiatric disorder" ], "offsets": [ [ 1161, 1181 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T62", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 1155, 1160 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T63", "type": "Scope", "text": [ "depression or other psychiatric disorder" ], "offsets": [ [ 1141, 1181 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T64", "type": "Condition", "text": [ "alcohol use or dependence" ], "offsets": [ [ 1331, 1356 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T65", "type": "Condition", "text": [ "or d", "at, in the opinio" ], "offsets": [ [ 1343, 1347 ], [ 1359, 1376 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T66", "type": "Temporal", "text": [ "Active" ], "offsets": [ [ 1316, 1322 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T67", "type": "Scope", "text": [ "drug or alcohol use or dependence" ], "offsets": [ [ 1323, 1356 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T68", "type": "Temporal", "text": [ "acute" ], "offsets": [ [ 1480, 1485 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T69", "type": "Temporal", "text": [ "active" ], "offsets": [ [ 1470, 1476 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T70", "type": "Condition", "text": [ "AIDS-defining opportunistic infections" ], "offsets": [ [ 1486, 1524 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T71", "type": "Temporal", "text": [ "within 12 weeks prior to study entry" ], "offsets": [ [ 1525, 1561 ] ], "normalized": [] }, { "id": "NCT02650024_exc_T72", "type": "Scope", "text": [ "active or acute" ], "offsets": [ [ 1470, 1485 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02650024_exc_R1", "type": "Subsumes", "arg1_id": "NCT02650024_exc_T2", "arg2_id": "NCT02650024_exc_T5", "normalized": [] }, { "id": "NCT02650024_exc_R2", "type": "Has_value", "arg1_id": "NCT02650024_exc_T7", "arg2_id": "NCT02650024_exc_T8", "normalized": [] }, { "id": "NCT02650024_exc_R3", "type": "AND", "arg1_id": "NCT02650024_exc_T6", "arg2_id": "NCT02650024_exc_T7", "normalized": [] }, { "id": "NCT02650024_exc_R4", "type": "Has_temporal", "arg1_id": "NCT02650024_exc_T6", "arg2_id": "NCT02650024_exc_T9", "normalized": [] }, { "id": "NCT02650024_exc_R5", "type": "Has_temporal", "arg1_id": "NCT02650024_exc_T10", "arg2_id": "NCT02650024_exc_T11", "normalized": [] }, { "id": "NCT02650024_exc_R6", "type": "Has_value", "arg1_id": "NCT02650024_exc_T12", "arg2_id": "NCT02650024_exc_T13", "normalized": [] }, { "id": "NCT02650024_exc_R7", "type": "AND", "arg1_id": "NCT02650024_exc_T10", "arg2_id": "NCT02650024_exc_T12", "normalized": [] }, { "id": "NCT02650024_exc_R8", "type": "Has_value", "arg1_id": "NCT02650024_exc_T14", "arg2_id": "NCT02650024_exc_T15", "normalized": [] }, { "id": "NCT02650024_exc_R9", "type": "Has_value", "arg1_id": "NCT02650024_exc_T16", "arg2_id": "NCT02650024_exc_T17", "normalized": [] }, { "id": "NCT02650024_exc_R10", "type": "AND", "arg1_id": "NCT02650024_exc_T23", "arg2_id": "NCT02650024_exc_T22", "normalized": [] }, { "id": "NCT02650024_exc_R11", "type": "Subsumes", "arg1_id": "NCT02650024_exc_T33", "arg2_id": "NCT02650024_exc_T34", "normalized": [] }, { "id": "NCT02650024_exc_R12", "type": "Subsumes", "arg1_id": "NCT02650024_exc_T36", "arg2_id": "NCT02650024_exc_T37", "normalized": [] }, { "id": "NCT02650024_exc_R13", "type": "AND", "arg1_id": "NCT02650024_exc_T38", "arg2_id": "NCT02650024_exc_T36", "normalized": [] }, { "id": "NCT02650024_exc_R14", "type": "Has_scope", "arg1_id": "NCT02650024_exc_T38", "arg2_id": "NCT02650024_exc_T41", "normalized": [] }, { "id": "NCT02650024_exc_R15", "type": "Has_qualifier", "arg1_id": "NCT02650024_exc_T42", "arg2_id": "NCT02650024_exc_T43", "normalized": [] }, { "id": "NCT02650024_exc_R16", "type": "Subsumes", "arg1_id": "NCT02650024_exc_T42", "arg2_id": "NCT02650024_exc_T48", "normalized": [] }, { "id": "NCT02650024_exc_R17", "type": "Has_temporal", "arg1_id": "NCT02650024_exc_T42", "arg2_id": "NCT02650024_exc_T49", "normalized": [] }, { "id": "NCT02650024_exc_R18", "type": "AND", "arg1_id": "NCT02650024_exc_T51", "arg2_id": "NCT02650024_exc_T50", "normalized": [] }, { "id": "NCT02650024_exc_R19", "type": "AND", "arg1_id": "NCT02650024_exc_T55", "arg2_id": "NCT02650024_exc_T56", "normalized": [] }, { "id": "NCT02650024_exc_R20", "type": "AND", "arg1_id": "NCT02650024_exc_T54", "arg2_id": "NCT02650024_exc_T55", "normalized": [] }, { "id": "NCT02650024_exc_R21", "type": "Has_qualifier", "arg1_id": "NCT02650024_exc_T61", "arg2_id": "NCT02650024_exc_T62", "normalized": [] }, { "id": "NCT02650024_exc_R22", "type": "Has_scope", "arg1_id": "NCT02650024_exc_T63", "arg2_id": "NCT02650024_exc_T60", "normalized": [] }, { "id": "NCT02650024_exc_R23", "type": "Has_temporal", "arg1_id": "NCT02650024_exc_T67", "arg2_id": "NCT02650024_exc_T66", "normalized": [] }, { "id": "NCT02650024_exc_R24", "type": "Has_temporal", "arg1_id": "NCT02650024_exc_T70", "arg2_id": "NCT02650024_exc_T71", "normalized": [] }, { "id": "NCT02650024_exc_R25", "type": "Has_scope", "arg1_id": "NCT02650024_exc_T70", "arg2_id": "NCT02650024_exc_T72", "normalized": [] } ]

[ { "id": "NCT02650024_inc_text", "type": "inclusion", "text": [ "Adult (= 18 years old) subjects with chronic genotype 1 HCV and NCI with a GDS greater than or equal to 0.5 (n=60).\nPresence of chronic HCV infection based on chart review will be defined as positive for anti-HCV antibody or HCV RNA at least 6 months before screening.\nFor the HIV/HCV co-infected group only, subjects must have HIV. HIV status will be obtained through self report. Self report will be confirmed at screening using a HIV-1 point of care test. In the event that point of care test and self-report are discordant, then HIV status will be confirmed by a licensed Western blot or a second antibody test.\nHIV/HCV co-infected subjects (n=12) must also have a HIV RNA measurement <50 copies/mL at the pre-treatment visit.\nPlatelets >150,000\nAspartate aminotransferase (AST)/Alanine aminotransferase (ALT) <10x upper limit of normal\nCreatinine clearance >30 milliliters/minute/1.73 centimeter squared\n" ], "offsets": [ [ 0, 909 ] ] } ]

[ { "id": "NCT02650024_inc_T1", "type": "Person", "text": [ "Adult" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T2", "type": "Value", "text": [ "= 18 years old" ], "offsets": [ [ 7, 21 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T3", "type": "Person", "text": [ "old" ], "offsets": [ [ 18, 21 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T4", "type": "Qualifier", "text": [ "genotype 1" ], "offsets": [ [ 45, 55 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T5", "type": "Temporal", "text": [ "chronic" ], "offsets": [ [ 37, 44 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T6", "type": "Condition", "text": [ "HCV" ], "offsets": [ [ 56, 59 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T7", "type": "Condition", "text": [ "NCI" ], "offsets": [ [ 64, 67 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T8", "type": "Measurement", "text": [ "GDS" ], "offsets": [ [ 75, 78 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T9", "type": "Value", "text": [ "greater than or equal to 0.5" ], "offsets": [ [ 79, 107 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T10", "type": "Scope", "text": [ "HCV and NCI" ], "offsets": [ [ 56, 67 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T11", "type": "Temporal", "text": [ "chronic" ], "offsets": [ [ 128, 135 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T12", "type": "Condition", "text": [ "HCV infection" ], "offsets": [ [ 136, 149 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T13", "type": "Measurement", "text": [ "anti-HCV antibody" ], "offsets": [ [ 204, 221 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T14", "type": "Value", "text": [ "positive" ], "offsets": [ [ 191, 199 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T15", "type": "Measurement", "text": [ "HCV RNA" ], "offsets": [ [ 225, 232 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T16", "type": "Scope", "text": [ "anti-HCV antibody or HCV RNA" ], "offsets": [ [ 204, 232 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T17", "type": "Temporal", "text": [ "at least 6 months before screening" ], "offsets": [ [ 233, 267 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T19", "type": "Condition", "text": [ "HIV" ], "offsets": [ [ 616, 619 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T20", "type": "Condition", "text": [ "HCV" ], "offsets": [ [ 620, 623 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T21", "type": "Condition", "text": [ "co-infected" ], "offsets": [ [ 624, 635 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T22", "type": "Measurement", "text": [ "HIV RNA measurement" ], "offsets": [ [ 669, 688 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T23", "type": "Value", "text": [ "<50 copies/mL" ], "offsets": [ [ 689, 702 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T24", "type": "Temporal", "text": [ "at the pre-treatment visit" ], "offsets": [ [ 703, 729 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T25", "type": "Measurement", "text": [ "Platelets" ], "offsets": [ [ 731, 740 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T26", "type": "Scope", "text": [ "HIV/HCV co-infected" ], "offsets": [ [ 616, 635 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T27", "type": "Value", "text": [ ">150,000" ], "offsets": [ [ 741, 749 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T28", "type": "Measurement", "text": [ "Aspartate aminotransferase (AST)" ], "offsets": [ [ 750, 782 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T29", "type": "Measurement", "text": [ "Alanine aminotransferase (ALT)" ], "offsets": [ [ 783, 813 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T30", "type": "Value", "text": [ "<10x upper limit of normal" ], "offsets": [ [ 814, 840 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T31", "type": "Measurement", "text": [ "Creatinine clearance" ], "offsets": [ [ 841, 861 ] ], "normalized": [] }, { "id": "NCT02650024_inc_T32", "type": "Value", "text": [ ">30 milliliters/minute/1.73 centimeter squared" ], "offsets": [ [ 862, 908 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02650024_inc_R1", "type": "Has_value", "arg1_id": "NCT02650024_inc_T3", "arg2_id": "NCT02650024_inc_T2", "normalized": [] }, { "id": "NCT02650024_inc_R2", "type": "Subsumes", "arg1_id": "NCT02650024_inc_T1", "arg2_id": "NCT02650024_inc_T3", "normalized": [] }, { "id": "NCT02650024_inc_R3", "type": "Has_value", "arg1_id": "NCT02650024_inc_T8", "arg2_id": "NCT02650024_inc_T9", "normalized": [] }, { "id": "NCT02650024_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT02650024_inc_T10", "arg2_id": "NCT02650024_inc_T4", "normalized": [] }, { "id": "NCT02650024_inc_R5", "type": "Has_temporal", "arg1_id": "NCT02650024_inc_T10", "arg2_id": "NCT02650024_inc_T5", "normalized": [] }, { "id": "NCT02650024_inc_R6", "type": "AND", "arg1_id": "NCT02650024_inc_T10", "arg2_id": "NCT02650024_inc_T8", "normalized": [] }, { "id": "NCT02650024_inc_R7", "type": "Has_temporal", "arg1_id": "NCT02650024_inc_T12", "arg2_id": "NCT02650024_inc_T11", "normalized": [] }, { "id": "NCT02650024_inc_R8", "type": "Has_value", "arg1_id": "NCT02650024_inc_T16", "arg2_id": "NCT02650024_inc_T14", "normalized": [] }, { "id": "NCT02650024_inc_R9", "type": "Has_temporal", "arg1_id": "NCT02650024_inc_T16", "arg2_id": "NCT02650024_inc_T17", "normalized": [] }, { "id": "NCT02650024_inc_R10", "type": "Has_scope", "arg1_id": "NCT02650024_inc_T12", "arg2_id": "NCT02650024_inc_T16", "normalized": [] }, { "id": "NCT02650024_inc_R11", "type": "AND", "arg1_id": "NCT02650024_inc_T21", "arg2_id": "NCT02650024_inc_T20", "normalized": [] }, { "id": "NCT02650024_inc_R12", "type": "AND", "arg1_id": "NCT02650024_inc_T21", "arg2_id": "NCT02650024_inc_T19", "normalized": [] }, { "id": "NCT02650024_inc_R13", "type": "Has_value", "arg1_id": "NCT02650024_inc_T22", "arg2_id": "NCT02650024_inc_T23", "normalized": [] }, { "id": "NCT02650024_inc_R14", "type": "Has_temporal", "arg1_id": "NCT02650024_inc_T22", "arg2_id": "NCT02650024_inc_T24", "normalized": [] }, { "id": "NCT02650024_inc_R15", "type": "AND", "arg1_id": "NCT02650024_inc_T26", "arg2_id": "NCT02650024_inc_T22", "normalized": [] }, { "id": "NCT02650024_inc_R16", "type": "Has_value", "arg1_id": "NCT02650024_inc_T25", "arg2_id": "NCT02650024_inc_T27", "normalized": [] }, { "id": "NCT02650024_inc_R17", "type": "Has_value", "arg1_id": "NCT02650024_inc_T29", "arg2_id": "NCT02650024_inc_T30", "normalized": [] }, { "id": "NCT02650024_inc_R18", "type": "Has_value", "arg1_id": "NCT02650024_inc_T28", "arg2_id": "NCT02650024_inc_T30", "normalized": [] }, { "id": "NCT02650024_inc_R19", "type": "Has_value", "arg1_id": "NCT02650024_inc_T31", "arg2_id": "NCT02650024_inc_T32", "normalized": [] } ]

[ { "id": "NCT02650388_exc_text", "type": "exclusion", "text": [ "Died before TAVI\nNot willing to participate\n" ], "offsets": [ [ 0, 44 ] ] } ]

[ { "id": "NCT02650388_exc_T1", "type": "Observation", "text": [ "Died" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "NCT02650388_exc_T2", "type": "Temporal", "text": [ "before TAVI" ], "offsets": [ [ 5, 16 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02650388_exc_R1", "type": "Has_temporal", "arg1_id": "NCT02650388_exc_T1", "arg2_id": "NCT02650388_exc_T2", "normalized": [] } ]

[ { "id": "NCT02650388_inc_text", "type": "inclusion", "text": [ "Age = 75 years,\nSevere, symptomatic aortic stenosis,\nHigh risk for cardiac surgery (STS and logistic Euroscore ),\nAccording multidisciplinary (heart) team decision TAVI is preferable,\nWilling to participate\n" ], "offsets": [ [ 0, 207 ] ] } ]

[ { "id": "NCT02650388_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02650388_inc_T2", "type": "Value", "text": [ "= 75 years" ], "offsets": [ [ 4, 14 ] ], "normalized": [] }, { "id": "NCT02650388_inc_T3", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 16, 22 ] ], "normalized": [] }, { "id": "NCT02650388_inc_T4", "type": "Qualifier", "text": [ "symptomatic" ], "offsets": [ [ 24, 35 ] ], "normalized": [] }, { "id": "NCT02650388_inc_T5", "type": "Condition", "text": [ "aortic stenosis" ], "offsets": [ [ 36, 51 ] ], "normalized": [] }, { "id": "NCT02650388_inc_T6", "type": "Qualifier", "text": [ "High risk" ], "offsets": [ [ 53, 62 ] ], "normalized": [] }, { "id": "NCT02650388_inc_T7", "type": "Procedure", "text": [ "cardiac surgery" ], "offsets": [ [ 67, 82 ] ], "normalized": [] }, { "id": "NCT02650388_inc_T8", "type": "Qualifier", "text": [ "STS" ], "offsets": [ [ 84, 87 ] ], "normalized": [] }, { "id": "NCT02650388_inc_T9", "type": "Qualifier", "text": [ "logistic Euroscore" ], "offsets": [ [ 92, 110 ] ], "normalized": [] }, { "id": "NCT02650388_inc_T10", "type": "Scope", "text": [ "STS and logistic Euroscore" ], "offsets": [ [ 84, 110 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02650388_inc_R1", "type": "Has_value", "arg1_id": "NCT02650388_inc_T1", "arg2_id": "NCT02650388_inc_T2", "normalized": [] }, { "id": "NCT02650388_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02650388_inc_T5", "arg2_id": "NCT02650388_inc_T4", "normalized": [] }, { "id": "NCT02650388_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT02650388_inc_T5", "arg2_id": "NCT02650388_inc_T3", "normalized": [] }, { "id": "NCT02650388_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT02650388_inc_T7", "arg2_id": "NCT02650388_inc_T6", "normalized": [] }, { "id": "NCT02650388_inc_R5", "type": "Has_scope", "arg1_id": "NCT02650388_inc_T7", "arg2_id": "NCT02650388_inc_T10", "normalized": [] } ]

[ { "id": "NCT02652572_exc_text", "type": "exclusion", "text": [ "1. Decrease in size of the designated target ulcer(s) by ≥ 30% during the 7-day screening period \n2. Cannot tolerate or comply with compression therapy. \n3. An ulcer which shows signs of severe clinical infection, defined as pus oozing from the ulcer site \n4. An ulcer positive for β-hemolytic streptococci upon culture \n5. The ulcer has > 50% slough, significant necrotic tissue, bone, tendon, or capsule exposure or avascular ulcer beds \n6. Is highly exuding (i.e. requires daily change of dressing) \n7. Ankle brachial pressure index <0.65 \n8. Patients with active systemic infections \n9. Patients with clinically significant medical conditions as determined by the investigator including renal, hepatic, hematologic, neurologic or immune disease. Examples include but are not limited to: \n1. Renal insufficiency as an estimated GFR which is < 30 mL/min/1.7m2 \n2. Abnormal blood biochemistry defined as 3 times that of the upper limit of the normal range. \n3. Hepatic insufficiency defined as total bilirubin > 2 mg/dL or serum albumin < 25 g/L \n4. HbA1c > 9% \n5. Hemoglobin < 10 g/dL \n6. Hematocrit < 0.30 \n7. Platelet count < 100,000 \n10. Presence of an active systemic or local cancer or tumor of any kind (with the exception of non-melanoma skin cancer) \n11. Patients with severe rheumatoid arthritis (with more than 20 persistently inflamed joints, or below lower normal limit blood albumin level, or evidence of bone and cartilage damage on x-ray, or inflammation in tissues other than joints) and other collagen vascular diseases. \n12. Patients with active connective tissue disease \n13. Treatment with systemic corticosteroids (>15 mg/day), or current immunosuppressive agents \n14. Previous or current radiation therapy or likelihood to receive this therapy during study participation \n15. Pregnant or nursing patients \n16. Known prior inability or unavailability to complete required study visits during study participation \n17. Significant peripheral edema as per investigator's discretion \n18. A psychiatric condition (e.g., suicidal ideation) or chronic alcohol or drug abuse problem, determined from the patient's medical history, which, in the opinion of the investigator, may pose a threat to patient compliance \n19. Use of a platelet-derived growth factor within 28 days before screening \n20. Use of any investigational drug or therapy within 28 days before screening \n21. Has any other factor which may, in the opinion of the investigator, compromise participation and/or follow-up in the study \n \n" ], "offsets": [ [ 0, 2526 ] ] } ]

[ { "id": "NCT02652572_exc_T29", "type": "Condition", "text": [ "target ulcer" ], "offsets": [ [ 38, 50 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T30", "type": "Qualifier", "text": [ "Decrease in size" ], "offsets": [ [ 3, 19 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T31", "type": "Value", "text": [ "≥ 30%" ], "offsets": [ [ 57, 62 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T32", "type": "Temporal", "text": [ "during the 7-day screening period" ], "offsets": [ [ 63, 96 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T33", "type": "Procedure", "text": [ "compression therapy" ], "offsets": [ [ 132, 151 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T36", "type": "Condition", "text": [ "pus" ], "offsets": [ [ 225, 228 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T37", "type": "Condition", "text": [ "ulcer" ], "offsets": [ [ 160, 165 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T38", "type": "Qualifier", "text": [ "shows signs of severe clinical infection" ], "offsets": [ [ 172, 212 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T40", "type": "Condition", "text": [ "severe clinical infection" ], "offsets": [ [ 187, 212 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T41", "type": "Condition", "text": [ "ulcer" ], "offsets": [ [ 263, 268 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T42", "type": "Qualifier", "text": [ "positive for β-hemolytic streptococci" ], "offsets": [ [ 269, 306 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T43", "type": "Measurement", "text": [ "slough" ], "offsets": [ [ 344, 350 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T44", "type": "Value", "text": [ "> 50%" ], "offsets": [ [ 338, 343 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T45", "type": "Condition", "text": [ "ulcer" ], "offsets": [ [ 328, 333 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T46", "type": "Observation", "text": [ "necrotic tissue" ], "offsets": [ [ 364, 379 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T47", "type": "Observation", "text": [ "bone", "exposure" ], "offsets": [ [ 381, 385 ], [ 406, 414 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T48", "type": "Observation", "text": [ "capsule exposure" ], "offsets": [ [ 398, 414 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T49", "type": "Observation", "text": [ "tendon", "exposure" ], "offsets": [ [ 387, 393 ], [ 406, 414 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T50", "type": "Observation", "text": [ "avascular ulcer beds" ], "offsets": [ [ 418, 438 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T51", "type": "Qualifier", "text": [ "highly exuding" ], "offsets": [ [ 446, 460 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T53", "type": "Multiplier", "text": [ "daily" ], "offsets": [ [ 476, 481 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T54", "type": "Procedure", "text": [ "change of dressing" ], "offsets": [ [ 482, 500 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T55", "type": "Measurement", "text": [ "Ankle brachial pressure index" ], "offsets": [ [ 506, 535 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T56", "type": "Value", "text": [ "<0.65" ], "offsets": [ [ 536, 541 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T57", "type": "Condition", "text": [ "systemic infections" ], "offsets": [ [ 567, 586 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T58", "type": "Temporal", "text": [ "active" ], "offsets": [ [ 560, 566 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T59", "type": "Condition", "text": [ "medical conditions" ], "offsets": [ [ 628, 646 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T60", "type": "Qualifier", "text": [ "clinically significant" ], "offsets": [ [ 605, 627 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T61", "type": "Observation", "text": [ "as determined by the investigator" ], "offsets": [ [ 647, 680 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T63", "type": "Condition", "text": [ "renal", "disease" ], "offsets": [ [ 691, 696 ], [ 741, 748 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T64", "type": "Condition", "text": [ "immune disease" ], "offsets": [ [ 734, 748 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T65", "type": "Condition", "text": [ "hepatic", "disease" ], "offsets": [ [ 698, 705 ], [ 741, 748 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T66", "type": "Condition", "text": [ "hematologic", "disease" ], "offsets": [ [ 707, 718 ], [ 741, 748 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T67", "type": "Condition", "text": [ "neurologic", "disease" ], "offsets": [ [ 720, 730 ], [ 741, 748 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T68", "type": "Scope", "text": [ "renal, hepatic, hematologic, neurologic or immune disease" ], "offsets": [ [ 691, 748 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T70", "type": "Condition", "text": [ "Renal insufficiency" ], "offsets": [ [ 795, 814 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T71", "type": "Measurement", "text": [ "estimated GFR" ], "offsets": [ [ 821, 834 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T72", "type": "Value", "text": [ "< 30 mL/min/1.7m2" ], "offsets": [ [ 844, 861 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T73", "type": "Measurement", "text": [ "blood biochemistry" ], "offsets": [ [ 875, 893 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T74", "type": "Value", "text": [ "3 times that of the upper limit of the normal range" ], "offsets": [ [ 905, 956 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T75", "type": "Value", "text": [ "Abnormal" ], "offsets": [ [ 866, 874 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T76", "type": "Condition", "text": [ "Hepatic insufficiency" ], "offsets": [ [ 962, 983 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T77", "type": "Measurement", "text": [ "total bilirubin" ], "offsets": [ [ 995, 1010 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T78", "type": "Value", "text": [ "> 2 mg/dL" ], "offsets": [ [ 1011, 1020 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T79", "type": "Measurement", "text": [ "serum albumin" ], "offsets": [ [ 1024, 1037 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T80", "type": "Value", "text": [ "< 25 g/L" ], "offsets": [ [ 1038, 1046 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T81", "type": "Scope", "text": [ "total bilirubin > 2 mg/dL or serum albumin < 25 g/L" ], "offsets": [ [ 995, 1046 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T82", "type": "Measurement", "text": [ "HbA1c" ], "offsets": [ [ 1051, 1056 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T83", "type": "Value", "text": [ "> 9%" ], "offsets": [ [ 1057, 1061 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T84", "type": "Measurement", "text": [ "Hemoglobin" ], "offsets": [ [ 1066, 1076 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T85", "type": "Value", "text": [ "< 10 g/dL" ], "offsets": [ [ 1077, 1086 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T86", "type": "Measurement", "text": [ "Hematocrit" ], "offsets": [ [ 1091, 1101 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T87", "type": "Value", "text": [ "< 0.30" ], "offsets": [ [ 1102, 1108 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T88", "type": "Measurement", "text": [ "Platelet count" ], "offsets": [ [ 1113, 1127 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T89", "type": "Value", "text": [ "< 100,000" ], "offsets": [ [ 1128, 1137 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T90", "type": "Condition", "text": [ "local cancer" ], "offsets": [ [ 1177, 1189 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T91", "type": "Condition", "text": [ "systemic", "cancer" ], "offsets": [ [ 1165, 1173 ], [ 1183, 1189 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T92", "type": "Temporal", "text": [ "active" ], "offsets": [ [ 1158, 1164 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T93", "type": "Condition", "text": [ "tumor of any kind" ], "offsets": [ [ 1193, 1210 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T94", "type": "Condition", "text": [ "non-melanoma skin cancer" ], "offsets": [ [ 1234, 1258 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T95", "type": "Negation", "text": [ "with the exception of" ], "offsets": [ [ 1212, 1233 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T96", "type": "Scope", "text": [ "systemic or local cancer or tumor of any kind" ], "offsets": [ [ 1165, 1210 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T97", "type": "Condition", "text": [ "rheumatoid arthritis" ], "offsets": [ [ 1286, 1306 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T98", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 1279, 1285 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T99", "type": "Multiplier", "text": [ "more than 20" ], "offsets": [ [ 1313, 1325 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T101", "type": "Condition", "text": [ "inflamed joints" ], "offsets": [ [ 1339, 1354 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T102", "type": "Temporal", "text": [ "persistently" ], "offsets": [ [ 1326, 1338 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T100", "type": "Measurement", "text": [ "blood albumin level" ], "offsets": [ [ 1384, 1403 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T103", "type": "Value", "text": [ "below lower normal limit" ], "offsets": [ [ 1359, 1383 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T104", "type": "Condition", "text": [ "bone and cartilage damage" ], "offsets": [ [ 1420, 1445 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T105", "type": "Procedure", "text": [ "x-ray" ], "offsets": [ [ 1449, 1454 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T106", "type": "Condition", "text": [ "inflammation in tissues other than joints" ], "offsets": [ [ 1459, 1500 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T107", "type": "Condition", "text": [ "collagen vascular diseases" ], "offsets": [ [ 1512, 1538 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T108", "type": "Scope", "text": [ "more than 20 persistently inflamed joints, or below lower normal limit blood albumin level, or evidence of bone and cartilage damage on x-ray, or inflammation in tissues other than joints" ], "offsets": [ [ 1313, 1500 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T109", "type": "Condition", "text": [ "connective tissue disease" ], "offsets": [ [ 1566, 1591 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T110", "type": "Temporal", "text": [ "active" ], "offsets": [ [ 1559, 1565 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T111", "type": "Drug", "text": [ "systemic corticosteroids" ], "offsets": [ [ 1612, 1636 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T112", "type": "Value", "text": [ ">15 mg/day" ], "offsets": [ [ 1638, 1648 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T113", "type": "Procedure", "text": [ "Treatment" ], "offsets": [ [ 1597, 1606 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T114", "type": "Drug", "text": [ "immunosuppressive agents" ], "offsets": [ [ 1662, 1686 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T115", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 1654, 1661 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T116", "type": "Procedure", "text": [ "radiation therapy" ], "offsets": [ [ 1712, 1729 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T119", "type": "Temporal", "text": [ "Previous" ], "offsets": [ [ 1692, 1700 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T120", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 1704, 1711 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T121", "type": "Scope", "text": [ "Previous or current" ], "offsets": [ [ 1692, 1711 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T122", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 1800, 1808 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T123", "type": "Condition", "text": [ "nursing" ], "offsets": [ [ 1812, 1819 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T126", "type": "Condition", "text": [ "peripheral edema" ], "offsets": [ [ 1952, 1968 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T127", "type": "Qualifier", "text": [ "Significant" ], "offsets": [ [ 1940, 1951 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T130", "type": "Condition", "text": [ "psychiatric condition" ], "offsets": [ [ 2009, 2030 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T131", "type": "Condition", "text": [ "suicidal ideation" ], "offsets": [ [ 2038, 2055 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T132", "type": "Condition", "text": [ "alcohol", "abuse problem" ], "offsets": [ [ 2068, 2075 ], [ 2084, 2097 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T133", "type": "Condition", "text": [ "drug abuse problem" ], "offsets": [ [ 2079, 2097 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T136", "type": "Qualifier", "text": [ "may pose a threat to patient compliance" ], "offsets": [ [ 2189, 2228 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T137", "type": "Scope", "text": [ "psychiatric condition (e.g., suicidal ideation) or chronic alcohol or drug abuse problem" ], "offsets": [ [ 2009, 2097 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T138", "type": "Drug", "text": [ "platelet-derived growth factor" ], "offsets": [ [ 2243, 2273 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T139", "type": "Temporal", "text": [ "within 28 days before screening" ], "offsets": [ [ 2274, 2305 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T140", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 2296, 2305 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T141", "type": "Drug", "text": [ "investigational drug" ], "offsets": [ [ 2322, 2342 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T142", "type": "Procedure", "text": [ "investigational", "therapy" ], "offsets": [ [ 2322, 2337 ], [ 2346, 2353 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T143", "type": "Temporal", "text": [ "within 28 days before screening" ], "offsets": [ [ 2354, 2385 ] ], "normalized": [] }, { "id": "NCT02652572_exc_T144", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 2376, 2385 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02652572_exc_R1", "type": "Has_temporal", "arg1_id": "NCT02652572_exc_T31", "arg2_id": "NCT02652572_exc_T32", "normalized": [] }, { "id": "NCT02652572_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT02652572_exc_T29", "arg2_id": "NCT02652572_exc_T30", "normalized": [] }, { "id": "NCT02652572_exc_R3", "type": "Has_value", "arg1_id": "NCT02652572_exc_T30", "arg2_id": "NCT02652572_exc_T31", "normalized": [] }, { "id": "NCT02652572_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT02652572_exc_T37", "arg2_id": "NCT02652572_exc_T38", "normalized": [] }, { "id": "NCT02652572_exc_R5", "type": "Subsumes", "arg1_id": "NCT02652572_exc_T38", "arg2_id": "NCT02652572_exc_T36", "normalized": [] }, { "id": "NCT02652572_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT02652572_exc_T41", "arg2_id": "NCT02652572_exc_T42", "normalized": [] }, { "id": "NCT02652572_exc_R7", "type": "AND", "arg1_id": "NCT02652572_exc_T45", "arg2_id": "NCT02652572_exc_T43", "normalized": [] }, { "id": "NCT02652572_exc_R8", "type": "Has_value", "arg1_id": "NCT02652572_exc_T43", "arg2_id": "NCT02652572_exc_T44", "normalized": [] }, { "id": "NCT02652572_exc_R9", "type": "Subsumes", "arg1_id": "NCT02652572_exc_T51", "arg2_id": "NCT02652572_exc_T54", "normalized": [] }, { "id": "NCT02652572_exc_R10", "type": "Has_multiplier", "arg1_id": "NCT02652572_exc_T54", "arg2_id": "NCT02652572_exc_T53", "normalized": [] }, { "id": "NCT02652572_exc_R11", "type": "Has_value", "arg1_id": "NCT02652572_exc_T55", "arg2_id": "NCT02652572_exc_T56", "normalized": [] }, { "id": "NCT02652572_exc_R12", "type": "Has_temporal", "arg1_id": "NCT02652572_exc_T57", "arg2_id": "NCT02652572_exc_T58", "normalized": [] }, { "id": "NCT02652572_exc_R13", "type": "Has_qualifier", "arg1_id": "NCT02652572_exc_T59", "arg2_id": "NCT02652572_exc_T60", "normalized": [] }, { "id": "NCT02652572_exc_R15", "type": "Subsumes", "arg1_id": "NCT02652572_exc_T60", "arg2_id": "NCT02652572_exc_T68", "normalized": [] }, { "id": "NCT02652572_exc_R16", "type": "Has_value", "arg1_id": "NCT02652572_exc_T71", "arg2_id": "NCT02652572_exc_T72", "normalized": [] }, { "id": "NCT02652572_exc_R17", "type": "AND", "arg1_id": "NCT02652572_exc_T70", "arg2_id": "NCT02652572_exc_T71", "normalized": [] }, { "id": "NCT02652572_exc_R18", "type": "Subsumes", "arg1_id": "NCT02652572_exc_T75", "arg2_id": "NCT02652572_exc_T74", "normalized": [] }, { "id": "NCT02652572_exc_R19", "type": "Has_value", "arg1_id": "NCT02652572_exc_T73", "arg2_id": "NCT02652572_exc_T75", "normalized": [] }, { "id": "NCT02652572_exc_R20", "type": "Has_value", "arg1_id": "NCT02652572_exc_T79", "arg2_id": "NCT02652572_exc_T80", "normalized": [] }, { "id": "NCT02652572_exc_R21", "type": "Has_value", "arg1_id": "NCT02652572_exc_T77", "arg2_id": "NCT02652572_exc_T78", "normalized": [] }, { "id": "NCT02652572_exc_R22", "type": "Subsumes", "arg1_id": "NCT02652572_exc_T76", "arg2_id": "NCT02652572_exc_T81", "normalized": [] }, { "id": "NCT02652572_exc_R23", "type": "Has_value", "arg1_id": "NCT02652572_exc_T82", "arg2_id": "NCT02652572_exc_T83", "normalized": [] }, { "id": "NCT02652572_exc_R24", "type": "Has_value", "arg1_id": "NCT02652572_exc_T84", "arg2_id": "NCT02652572_exc_T85", "normalized": [] }, { "id": "NCT02652572_exc_R25", "type": "Has_value", "arg1_id": "NCT02652572_exc_T86", "arg2_id": "NCT02652572_exc_T87", "normalized": [] }, { "id": "NCT02652572_exc_R26", "type": "Has_value", "arg1_id": "NCT02652572_exc_T88", "arg2_id": "NCT02652572_exc_T89", "normalized": [] }, { "id": "NCT02652572_exc_R27", "type": "Has_negation", "arg1_id": "NCT02652572_exc_T94", "arg2_id": "NCT02652572_exc_T95", "normalized": [] }, { "id": "NCT02652572_exc_R28", "type": "AND", "arg1_id": "NCT02652572_exc_T96", "arg2_id": "NCT02652572_exc_T94", "normalized": [] }, { "id": "NCT02652572_exc_R29", "type": "Has_temporal", "arg1_id": "NCT02652572_exc_T96", "arg2_id": "NCT02652572_exc_T92", "normalized": [] }, { "id": "NCT02652572_exc_R30", "type": "Has_qualifier", "arg1_id": "NCT02652572_exc_T97", "arg2_id": "NCT02652572_exc_T98", "normalized": [] }, { "id": "NCT02652572_exc_R31", "type": "Has_temporal", "arg1_id": "NCT02652572_exc_T101", "arg2_id": "NCT02652572_exc_T102", "normalized": [] }, { "id": "NCT02652572_exc_R32", "type": "Has_multiplier", "arg1_id": "NCT02652572_exc_T101", "arg2_id": "NCT02652572_exc_T99", "normalized": [] }, { "id": "NCT02652572_exc_R33", "type": "Has_value", "arg1_id": "NCT02652572_exc_T100", "arg2_id": "NCT02652572_exc_T103", "normalized": [] }, { "id": "NCT02652572_exc_R34", "type": "Subsumes", "arg1_id": "NCT02652572_exc_T98", "arg2_id": "NCT02652572_exc_T108", "normalized": [] }, { "id": "NCT02652572_exc_R35", "type": "Has_temporal", "arg1_id": "NCT02652572_exc_T109", "arg2_id": "NCT02652572_exc_T110", "normalized": [] }, { "id": "NCT02652572_exc_R36", "type": "Has_value", "arg1_id": "NCT02652572_exc_T111", "arg2_id": "NCT02652572_exc_T112", "normalized": [] }, { "id": "NCT02652572_exc_R37", "type": "AND", "arg1_id": "NCT02652572_exc_T113", "arg2_id": "NCT02652572_exc_T111", "normalized": [] }, { "id": "NCT02652572_exc_R38", "type": "Has_temporal", "arg1_id": "NCT02652572_exc_T114", "arg2_id": "NCT02652572_exc_T115", "normalized": [] }, { "id": "NCT02652572_exc_R39", "type": "Has_scope", "arg1_id": "NCT02652572_exc_T116", "arg2_id": "NCT02652572_exc_T121", "normalized": [] }, { "id": "NCT02652572_exc_R40", "type": "Has_qualifier", "arg1_id": "NCT02652572_exc_T126", "arg2_id": "NCT02652572_exc_T127", "normalized": [] }, { "id": "NCT02652572_exc_R41", "type": "Subsumes", "arg1_id": "NCT02652572_exc_T130", "arg2_id": "NCT02652572_exc_T131", "normalized": [] }, { "id": "NCT02652572_exc_R42", "type": "Has_qualifier", "arg1_id": "NCT02652572_exc_T137", "arg2_id": "NCT02652572_exc_T136", "normalized": [] }, { "id": "NCT02652572_exc_R43", "type": "Has_index", "arg1_id": "NCT02652572_exc_T139", "arg2_id": "NCT02652572_exc_T140", "normalized": [] }, { "id": "NCT02652572_exc_R44", "type": "Has_temporal", "arg1_id": "NCT02652572_exc_T138", "arg2_id": "NCT02652572_exc_T139", "normalized": [] }, { "id": "NCT02652572_exc_R45", "type": "Has_index", "arg1_id": "NCT02652572_exc_T143", "arg2_id": "NCT02652572_exc_T144", "normalized": [] } ]

[ { "id": "NCT02652572_inc_text", "type": "inclusion", "text": [ "1. Age 18 years or older \n2. Diagnosis of venous leg ulcer(s), as clinically determined by the investigator by a positive venous reflux test (venous refilling <20 seconds) using Doppler ultrasound for at least 4 weeks prior to screening day, which have not adequately responded to conventional ulcer therapy. \n3. Designated venous leg ulcer meets the following criteria at both the screening and baseline visits. If the patient has multiple ulcers, at least one ulcer must meet the following criteria at both the screening and baseline visits: \n1. Present for at least 4 weeks \n2. CEAP Classification Stage 6 \n3. Surface ulcer with an area > 15cm2 post debridement \n4. Viable, granulating wound (investigator discretion) \n4. Ulcers that extend through the epidermis but not through the muscle, tendon, or bone (Stage II or III ulcers as defined by the IAET). \n5. Female patients of childbearing potential must have a negative pregnancy test at screening and must agree to use hormonal contraceptive, intrauterine device, diaphragm with spermicide, condom with spermicide, or abstinence throughout until 2 weeks after the last administration of study drug \n6. Signed informed consent \n" ], "offsets": [ [ 0, 1184 ] ] } ]

[ { "id": "NCT02652572_inc_T11", "type": "Value", "text": [ "18 years or older" ], "offsets": [ [ 7, 24 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T12", "type": "Person", "text": [ "Age" ], "offsets": [ [ 3, 6 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T13", "type": "Condition", "text": [ "venous leg ulcer(s)" ], "offsets": [ [ 42, 61 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T14", "type": "Measurement", "text": [ "venous reflux test" ], "offsets": [ [ 122, 140 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T15", "type": "Value", "text": [ "positive" ], "offsets": [ [ 113, 121 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T16", "type": "Measurement", "text": [ "venous refilling" ], "offsets": [ [ 142, 158 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T17", "type": "Value", "text": [ "<20 seconds" ], "offsets": [ [ 159, 170 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T18", "type": "Procedure", "text": [ "Doppler ultrasound" ], "offsets": [ [ 178, 196 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T19", "type": "Temporal", "text": [ "at least 4 weeks prior to screening day" ], "offsets": [ [ 201, 240 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T20", "type": "Reference_point", "text": [ "screening day" ], "offsets": [ [ 227, 240 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T21", "type": "Observation", "text": [ "responded" ], "offsets": [ [ 268, 277 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T22", "type": "Negation", "text": [ "not" ], "offsets": [ [ 253, 256 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T23", "type": "Qualifier", "text": [ "adequately" ], "offsets": [ [ 257, 267 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T24", "type": "Procedure", "text": [ "conventional ulcer therapy" ], "offsets": [ [ 281, 307 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T25", "type": "Condition", "text": [ "venous leg ulcer" ], "offsets": [ [ 324, 340 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T27", "type": "Condition", "text": [ "ulcers" ], "offsets": [ [ 441, 447 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T28", "type": "Multiplier", "text": [ "multiple" ], "offsets": [ [ 432, 440 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T29", "type": "Multiplier", "text": [ "at least one" ], "offsets": [ [ 449, 461 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T30", "type": "Condition", "text": [ "ulcer" ], "offsets": [ [ 462, 467 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T32", "type": "Temporal", "text": [ "at least 4 weeks" ], "offsets": [ [ 560, 576 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T33", "type": "Qualifier", "text": [ "Present" ], "offsets": [ [ 548, 555 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T34", "type": "Measurement", "text": [ "CEAP Classification" ], "offsets": [ [ 581, 600 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T35", "type": "Value", "text": [ "Stage 6" ], "offsets": [ [ 601, 608 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T36", "type": "Condition", "text": [ "Surface ulcer" ], "offsets": [ [ 613, 626 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T37", "type": "Value", "text": [ "> 15cm2" ], "offsets": [ [ 640, 647 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T38", "type": "Measurement", "text": [ "area", "post debridement" ], "offsets": [ [ 635, 639 ], [ 648, 664 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T39", "type": "Qualifier", "text": [ "Viable" ], "offsets": [ [ 669, 675 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T40", "type": "Qualifier", "text": [ "granulating" ], "offsets": [ [ 677, 688 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T41", "type": "Condition", "text": [ "wound" ], "offsets": [ [ 689, 694 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T43", "type": "Condition", "text": [ "Ulcers" ], "offsets": [ [ 725, 731 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T44", "type": "Qualifier", "text": [ "extend through the epidermis" ], "offsets": [ [ 737, 765 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T45", "type": "Qualifier", "text": [ "extend", "through the muscle" ], "offsets": [ [ 737, 743 ], [ 774, 792 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T46", "type": "Negation", "text": [ "not" ], "offsets": [ [ 770, 773 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T47", "type": "Value", "text": [ "Stage II or III" ], "offsets": [ [ 811, 826 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T48", "type": "Measurement", "text": [ "IAET" ], "offsets": [ [ 852, 856 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T49", "type": "Condition", "text": [ "ulcers" ], "offsets": [ [ 827, 833 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T50", "type": "Qualifier", "text": [ "extend", "through the", "tendon" ], "offsets": [ [ 737, 743 ], [ 774, 785 ], [ 794, 800 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T51", "type": "Qualifier", "text": [ "extend", "through the", "bone" ], "offsets": [ [ 737, 743 ], [ 774, 785 ], [ 805, 809 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T52", "type": "Scope", "text": [ "Ulcers that extend through the epidermis but not through the muscle, tendon, or bone" ], "offsets": [ [ 725, 809 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T53", "type": "Scope", "text": [ "extend through the epidermis but not through the muscle, tendon, or bone" ], "offsets": [ [ 737, 809 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T54", "type": "Condition", "text": [ "childbearing potential" ], "offsets": [ [ 882, 904 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T55", "type": "Measurement", "text": [ "pregnancy test" ], "offsets": [ [ 926, 940 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T56", "type": "Value", "text": [ "negative" ], "offsets": [ [ 917, 925 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T57", "type": "Temporal", "text": [ "at screening" ], "offsets": [ [ 941, 953 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T58", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 944, 953 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T59", "type": "Drug", "text": [ "hormonal contraceptive" ], "offsets": [ [ 976, 998 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T60", "type": "Device", "text": [ "intrauterine device" ], "offsets": [ [ 1000, 1019 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T61", "type": "Device", "text": [ "diaphragm with spermicide" ], "offsets": [ [ 1021, 1046 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T62", "type": "Device", "text": [ "condom with spermicide" ], "offsets": [ [ 1048, 1070 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T63", "type": "Observation", "text": [ "abstinence" ], "offsets": [ [ 1075, 1085 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T64", "type": "Temporal", "text": [ "throughout until 2 weeks after the last administration of study drug" ], "offsets": [ [ 1086, 1154 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T65", "type": "Reference_point", "text": [ "last administration of study drug" ], "offsets": [ [ 1121, 1154 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T66", "type": "Person", "text": [ "Female" ], "offsets": [ [ 863, 869 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T67", "type": "Scope", "text": [ "Female patients of childbearing potential" ], "offsets": [ [ 863, 904 ] ], "normalized": [] }, { "id": "NCT02652572_inc_T68", "type": "Scope", "text": [ "negative pregnancy test at screening and must agree to use hormonal contraceptive, intrauterine device, diaphragm with spermicide, condom with spermicide, or abstinence" ], "offsets": [ [ 917, 1085 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02652572_inc_R1", "type": "Has_value", "arg1_id": "NCT02652572_inc_T12", "arg2_id": "NCT02652572_inc_T11", "normalized": [] }, { "id": "NCT02652572_inc_R2", "type": "Has_value", "arg1_id": "NCT02652572_inc_T14", "arg2_id": "NCT02652572_inc_T15", "normalized": [] }, { "id": "NCT02652572_inc_R3", "type": "Has_value", "arg1_id": "NCT02652572_inc_T16", "arg2_id": "NCT02652572_inc_T17", "normalized": [] }, { "id": "NCT02652572_inc_R4", "type": "Subsumes", "arg1_id": "NCT02652572_inc_T15", "arg2_id": "NCT02652572_inc_T16", "normalized": [] }, { "id": "NCT02652572_inc_R5", "type": "Has_index", "arg1_id": "NCT02652572_inc_T19", "arg2_id": "NCT02652572_inc_T20", "normalized": [] }, { "id": "NCT02652572_inc_R6", "type": "Has_temporal", "arg1_id": "NCT02652572_inc_T18", "arg2_id": "NCT02652572_inc_T19", "normalized": [] }, { "id": "NCT02652572_inc_R7", "type": "Has_negation", "arg1_id": "NCT02652572_inc_T21", "arg2_id": "NCT02652572_inc_T22", "normalized": [] }, { "id": "NCT02652572_inc_R8", "type": "Has_qualifier", "arg1_id": "NCT02652572_inc_T21", "arg2_id": "NCT02652572_inc_T23", "normalized": [] }, { "id": "NCT02652572_inc_R10", "type": "AND", "arg1_id": "NCT02652572_inc_T13", "arg2_id": "NCT02652572_inc_T14", "normalized": [] }, { "id": "NCT02652572_inc_R11", "type": "AND", "arg1_id": "NCT02652572_inc_T14", "arg2_id": "NCT02652572_inc_T18", "normalized": [] }, { "id": "NCT02652572_inc_R12", "type": "Has_multiplier", "arg1_id": "NCT02652572_inc_T27", "arg2_id": "NCT02652572_inc_T28", "normalized": [] }, { "id": "NCT02652572_inc_R13", "type": "Has_multiplier", "arg1_id": "NCT02652572_inc_T30", "arg2_id": "NCT02652572_inc_T29", "normalized": [] }, { "id": "NCT02652572_inc_R14", "type": "Has_temporal", "arg1_id": "NCT02652572_inc_T33", "arg2_id": "NCT02652572_inc_T32", "normalized": [] }, { "id": "NCT02652572_inc_R15", "type": "Has_value", "arg1_id": "NCT02652572_inc_T34", "arg2_id": "NCT02652572_inc_T35", "normalized": [] }, { "id": "NCT02652572_inc_R16", "type": "AND", "arg1_id": "NCT02652572_inc_T36", "arg2_id": "NCT02652572_inc_T38", "normalized": [] }, { "id": "NCT02652572_inc_R17", "type": "Has_value", "arg1_id": "NCT02652572_inc_T38", "arg2_id": "NCT02652572_inc_T37", "normalized": [] }, { "id": "NCT02652572_inc_R18", "type": "Has_qualifier", "arg1_id": "NCT02652572_inc_T41", "arg2_id": "NCT02652572_inc_T40", "normalized": [] }, { "id": "NCT02652572_inc_R19", "type": "Has_qualifier", "arg1_id": "NCT02652572_inc_T41", "arg2_id": "NCT02652572_inc_T39", "normalized": [] }, { "id": "NCT02652572_inc_R21", "type": "Has_negation", "arg1_id": "NCT02652572_inc_T45", "arg2_id": "NCT02652572_inc_T46", "normalized": [] }, { "id": "NCT02652572_inc_R22", "type": "AND", "arg1_id": "NCT02652572_inc_T49", "arg2_id": "NCT02652572_inc_T48", "normalized": [] }, { "id": "NCT02652572_inc_R23", "type": "Has_value", "arg1_id": "NCT02652572_inc_T48", "arg2_id": "NCT02652572_inc_T47", "normalized": [] }, { "id": "NCT02652572_inc_R24", "type": "Has_negation", "arg1_id": "NCT02652572_inc_T50", "arg2_id": "NCT02652572_inc_T46", "normalized": [] }, { "id": "NCT02652572_inc_R25", "type": "Has_negation", "arg1_id": "NCT02652572_inc_T51", "arg2_id": "NCT02652572_inc_T46", "normalized": [] }, { "id": "NCT02652572_inc_R26", "type": "Subsumes", "arg1_id": "NCT02652572_inc_T52", "arg2_id": "NCT02652572_inc_T49", "normalized": [] }, { "id": "NCT02652572_inc_R27", "type": "Has_scope", "arg1_id": "NCT02652572_inc_T43", "arg2_id": "NCT02652572_inc_T53", "normalized": [] }, { "id": "NCT02652572_inc_R28", "type": "Has_value", "arg1_id": "NCT02652572_inc_T55", "arg2_id": "NCT02652572_inc_T56", "normalized": [] }, { "id": "NCT02652572_inc_R29", "type": "Has_index", "arg1_id": "NCT02652572_inc_T57", "arg2_id": "NCT02652572_inc_T58", "normalized": [] }, { "id": "NCT02652572_inc_R30", "type": "Has_temporal", "arg1_id": "NCT02652572_inc_T55", "arg2_id": "NCT02652572_inc_T57", "normalized": [] }, { "id": "NCT02652572_inc_R31", "type": "Has_index", "arg1_id": "NCT02652572_inc_T64", "arg2_id": "NCT02652572_inc_T65", "normalized": [] }, { "id": "NCT02652572_inc_R32", "type": "Has_temporal", "arg1_id": "NCT02652572_inc_T68", "arg2_id": "NCT02652572_inc_T64", "normalized": [] }, { "id": "NCT02652572_inc_R33", "type": "Has_scope", "arg1_id": "NCT02652572_inc_T67", "arg2_id": "NCT02652572_inc_T68", "normalized": [] } ]

[ { "id": "NCT02652637_exc_text", "type": "exclusion", "text": [ "Emergency surgery needed\nBowel obstruction\nColonoscopy scheduled to be undertaken peroperatively\nOther reason indicating mechanical preparation or contradicting it\nAllergy to used drugs (PEG, neomycin, metronidazole)\n" ], "offsets": [ [ 0, 217 ] ] } ]

[ { "id": "NCT02652637_exc_T1", "type": "Procedure", "text": [ "Emergency surgery" ], "offsets": [ [ 0, 17 ] ], "normalized": [] }, { "id": "NCT02652637_exc_T2", "type": "Mood", "text": [ "needed" ], "offsets": [ [ 18, 24 ] ], "normalized": [] }, { "id": "NCT02652637_exc_T3", "type": "Condition", "text": [ "Bowel obstruction" ], "offsets": [ [ 25, 42 ] ], "normalized": [] }, { "id": "NCT02652637_exc_T4", "type": "Procedure", "text": [ "Colonoscopy" ], "offsets": [ [ 43, 54 ] ], "normalized": [] }, { "id": "NCT02652637_exc_T5", "type": "Temporal", "text": [ "peroperatively" ], "offsets": [ [ 82, 96 ] ], "normalized": [] }, { "id": "NCT02652637_exc_T6", "type": "Mood", "text": [ "scheduled" ], "offsets": [ [ 55, 64 ] ], "normalized": [] }, { "id": "NCT02652637_exc_T7", "type": "Procedure", "text": [ "undertaken" ], "offsets": [ [ 71, 81 ] ], "normalized": [] }, { "id": "NCT02652637_exc_T8", "type": "Procedure", "text": [ "mechanical preparation" ], "offsets": [ [ 121, 143 ] ], "normalized": [] }, { "id": "NCT02652637_exc_T9", "type": "Condition", "text": [ "contradicting" ], "offsets": [ [ 147, 160 ] ], "normalized": [] }, { "id": "NCT02652637_exc_T10", "type": "Drug", "text": [ "drugs" ], "offsets": [ [ 180, 185 ] ], "normalized": [] }, { "id": "NCT02652637_exc_T11", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 164, 171 ] ], "normalized": [] }, { "id": "NCT02652637_exc_T12", "type": "Drug", "text": [ "PEG" ], "offsets": [ [ 187, 190 ] ], "normalized": [] }, { "id": "NCT02652637_exc_T13", "type": "Drug", "text": [ "neomycin" ], "offsets": [ [ 192, 200 ] ], "normalized": [] }, { "id": "NCT02652637_exc_T14", "type": "Drug", "text": [ "metronidazole" ], "offsets": [ [ 202, 215 ] ], "normalized": [] }, { "id": "NCT02652637_exc_T15", "type": "Scope", "text": [ "PEG, neomycin, metronidazole" ], "offsets": [ [ 187, 215 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02652637_exc_R1", "type": "Has_mood", "arg1_id": "NCT02652637_exc_T1", "arg2_id": "NCT02652637_exc_T2", "normalized": [] }, { "id": "NCT02652637_exc_R2", "type": "Has_temporal", "arg1_id": "NCT02652637_exc_T7", "arg2_id": "NCT02652637_exc_T5", "normalized": [] }, { "id": "NCT02652637_exc_R3", "type": "Has_mood", "arg1_id": "NCT02652637_exc_T7", "arg2_id": "NCT02652637_exc_T6", "normalized": [] }, { "id": "NCT02652637_exc_R4", "type": "AND", "arg1_id": "NCT02652637_exc_T4", "arg2_id": "NCT02652637_exc_T7", "normalized": [] }, { "id": "NCT02652637_exc_R5", "type": "AND", "arg1_id": "NCT02652637_exc_T9", "arg2_id": "NCT02652637_exc_T8", "normalized": [] }, { "id": "NCT02652637_exc_R6", "type": "Subsumes", "arg1_id": "NCT02652637_exc_T10", "arg2_id": "NCT02652637_exc_T15", "normalized": [] }, { "id": "NCT02652637_exc_R7", "type": "AND", "arg1_id": "NCT02652637_exc_T11", "arg2_id": "NCT02652637_exc_T10", "normalized": [] } ]

[ { "id": "NCT02652637_inc_text", "type": "inclusion", "text": [ "Patients undergoing colon resection\n" ], "offsets": [ [ 0, 36 ] ] } ]

[ { "id": "NCT02652637_inc_T1", "type": "Condition", "text": [ "colon resection" ], "offsets": [ [ 20, 35 ] ], "normalized": [] }, { "id": "NCT02652637_inc_T2", "type": "Temporal", "text": [ "undergoing" ], "offsets": [ [ 9, 19 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02652637_inc_R1", "type": "Has_temporal", "arg1_id": "NCT02652637_inc_T1", "arg2_id": "NCT02652637_inc_T2", "normalized": [] } ]

[ { "id": "NCT02653131_exc_text", "type": "exclusion", "text": [ "HPN < 12 months\nmetabolically unstable\ncancer as the reason for intestinal failure\n" ], "offsets": [ [ 0, 83 ] ] } ]

[ { "id": "NCT02653131_exc_T1", "type": "Measurement", "text": [ "HPN" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT02653131_exc_T2", "type": "Value", "text": [ "< 12 months" ], "offsets": [ [ 4, 15 ] ], "normalized": [] }, { "id": "NCT02653131_exc_T3", "type": "Condition", "text": [ "metabolically unstable" ], "offsets": [ [ 16, 38 ] ], "normalized": [] }, { "id": "NCT02653131_exc_T4", "type": "Condition", "text": [ "cancer" ], "offsets": [ [ 39, 45 ] ], "normalized": [] }, { "id": "NCT02653131_exc_T5", "type": "Condition", "text": [ "intestinal failure" ], "offsets": [ [ 64, 82 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02653131_exc_R1", "type": "Has_value", "arg1_id": "NCT02653131_exc_T1", "arg2_id": "NCT02653131_exc_T2", "normalized": [] }, { "id": "NCT02653131_exc_R2", "type": "AND", "arg1_id": "NCT02653131_exc_T4", "arg2_id": "NCT02653131_exc_T5", "normalized": [] } ]

[ { "id": "NCT02653131_inc_text", "type": "inclusion", "text": [ "patients receiving home parenteral nutrition (HPN) because of short bowel syndrome for at least 12 months\nstable metabolic status\nbenign disease\n" ], "offsets": [ [ 0, 145 ] ] } ]

[ { "id": "NCT02653131_inc_T1", "type": "Measurement", "text": [ "home parenteral nutrition (HPN)" ], "offsets": [ [ 19, 50 ] ], "normalized": [] }, { "id": "NCT02653131_inc_T2", "type": "Condition", "text": [ "short bowel syndrome" ], "offsets": [ [ 62, 82 ] ], "normalized": [] }, { "id": "NCT02653131_inc_T3", "type": "Temporal", "text": [ "for at least 12 months" ], "offsets": [ [ 83, 105 ] ], "normalized": [] }, { "id": "NCT02653131_inc_T4", "type": "Scope", "text": [ "home parenteral nutrition (HPN) because of short bowel syndrome" ], "offsets": [ [ 19, 82 ] ], "normalized": [] }, { "id": "NCT02653131_inc_T5", "type": "Measurement", "text": [ "metabolic status" ], "offsets": [ [ 113, 129 ] ], "normalized": [] }, { "id": "NCT02653131_inc_T6", "type": "Qualifier", "text": [ "stable" ], "offsets": [ [ 106, 112 ] ], "normalized": [] }, { "id": "NCT02653131_inc_T7", "type": "Condition", "text": [ "benign disease" ], "offsets": [ [ 130, 144 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT02653131_inc_R1", "type": "Has_temporal", "arg1_id": "NCT02653131_inc_T4", "arg2_id": "NCT02653131_inc_T3", "normalized": [] }, { "id": "NCT02653131_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT02653131_inc_T5", "arg2_id": "NCT02653131_inc_T6", "normalized": [] } ]