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split_0_train_300 | split_0_train_300 | [
{
"id": "split_0_train_300_passage",
"type": "progene_text",
"text": [
"In all 3 patients , systemic features improved , liver function results returned to normal , and cryocrit values decreased ."
],
"offsets": [
[
0,
124
]
]
}
] | [] | [] | [] | [] |
split_0_train_301 | split_0_train_301 | [
{
"id": "split_0_train_301_passage",
"type": "progene_text",
"text": [
"However , ischemic lesions became less vascularized and ischemia progressed , leading to transmetatarsal and subcondylar amputation , respectively , in 2 of the patients and fingertip necrosis and ulcer enlargement in the third ."
],
"offsets": [
[
0,
229
]
]
}
] | [] | [] | [] | [] |
split_0_train_302 | split_0_train_302 | [
{
"id": "split_0_train_302_passage",
"type": "progene_text",
"text": [
"Skin biopsies performed before IFNalpha therapy and after 2 months of IFNalpha therapy in the third patient showed a significant decrease in subepidermal microvessels ."
],
"offsets": [
[
0,
168
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]
}
] | [
{
"id": "split_0_train_459_entity",
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"IFNalpha"
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31,
39
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{
"id": "split_0_train_460_entity",
"type": "progene_text",
"text": [
"IFNalpha"
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[
70,
78
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_303 | split_0_train_303 | [
{
"id": "split_0_train_303_passage",
"type": "progene_text",
"text": [
"When IFNalpha was discontinued , the lesions finally healed ."
],
"offsets": [
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0,
61
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]
}
] | [
{
"id": "split_0_train_461_entity",
"type": "progene_text",
"text": [
"IFNalpha"
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[
5,
13
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}
] | [] | [] | [] |
split_0_train_304 | split_0_train_304 | [
{
"id": "split_0_train_304_passage",
"type": "progene_text",
"text": [
"Cryoglobulinemia - related ischemic lesions may worsen during IFNalpha treatment , presumably through a decrease in inflammation - induced angiogenesis ."
],
"offsets": [
[
0,
153
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]
}
] | [
{
"id": "split_0_train_462_entity",
"type": "progene_text",
"text": [
"IFNalpha"
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[
62,
70
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_305 | split_0_train_305 | [
{
"id": "split_0_train_305_passage",
"type": "progene_text",
"text": [
"The anti - angiogenic activity of IFNalpha may delay the appropriate healing of ischemic lesions ."
],
"offsets": [
[
0,
98
]
]
}
] | [
{
"id": "split_0_train_463_entity",
"type": "progene_text",
"text": [
"IFNalpha"
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"offsets": [
[
34,
42
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_306 | split_0_train_306 | [
{
"id": "split_0_train_306_passage",
"type": "progene_text",
"text": [
"Sequence of the genomic RNA of nudaurelia beta virus ( Tetraviridae ) defines a novel virus genome organization ."
],
"offsets": [
[
0,
113
]
]
}
] | [] | [] | [] | [] |
split_0_train_307 | split_0_train_307 | [
{
"id": "split_0_train_307_passage",
"type": "progene_text",
"text": [
"The monopartite genome of Nudaurelia beta virus , the type species of the Betatetravirus genus of the family Tetraviridae , consists of a single - stranded positive - sense RNA ( ss + RNA ) of 6625 nucleotides containing two open reading frames ( ORFs ) ."
],
"offsets": [
[
0,
255
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]
}
] | [] | [] | [] | [] |
split_0_train_308 | split_0_train_308 | [
{
"id": "split_0_train_308_passage",
"type": "progene_text",
"text": [
"The 5' proximal ORF of 5778 nucleotides encodes a protein of 215 kDa containing three functional domains characteristic of RNA - dependent RNA polymerases of ss + RNA viruses ."
],
"offsets": [
[
0,
176
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]
}
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{
"id": "split_0_train_464_entity",
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"text": [
"RNA - dependent RNA polymerases"
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"offsets": [
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123,
154
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_309 | split_0_train_309 | [
{
"id": "split_0_train_309_passage",
"type": "progene_text",
"text": [
"The 3' proximal ORF of 1836 nucleotides , which encodes the 66 - kDa capsid precursor protein , overlaps the replicase gene by more than 99 % ( 1827 nucleotides ) and is in the + 1 reading frame relative to the replicase reading frame ."
],
"offsets": [
[
0,
236
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}
] | [
{
"id": "split_0_train_465_entity",
"type": "progene_text",
"text": [
"capsid precursor protein"
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{
"id": "split_0_train_466_entity",
"type": "progene_text",
"text": [
"replicase"
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"offsets": [
[
211,
220
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_310 | split_0_train_310 | [
{
"id": "split_0_train_310_passage",
"type": "progene_text",
"text": [
"This capsid precursor is expressed via a 2656 - nucleotide subgenomic RNA ."
],
"offsets": [
[
0,
75
]
]
}
] | [] | [] | [] | [] |
split_0_train_311 | split_0_train_311 | [
{
"id": "split_0_train_311_passage",
"type": "progene_text",
"text": [
"The 3' terminus of the genome can be folded into a tRNA - like secondary structure that has a valine anticodon ; the tRNA - like structure lacks a pseudoknot in the aminoacyl stem , a feature common to both genera of tetraviruses ."
],
"offsets": [
[
0,
231
]
]
}
] | [] | [] | [] | [] |
split_0_train_312 | split_0_train_312 | [
{
"id": "split_0_train_312_passage",
"type": "progene_text",
"text": [
"Comparison of the sequences of Nudaurelia beta virus and another member of the Tetraviridae , Helicoverpa armigera stunt virus , which is in the genus Omegatetravirus , shows identities of 31.6 % for the replicase and 24.5 % for the capsid protein ."
],
"offsets": [
[
0,
249
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]
}
] | [
{
"id": "split_0_train_467_entity",
"type": "progene_text",
"text": [
"replicase"
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204,
213
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},
{
"id": "split_0_train_468_entity",
"type": "progene_text",
"text": [
"capsid protein"
],
"offsets": [
[
233,
247
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_313 | split_0_train_313 | [
{
"id": "split_0_train_313_passage",
"type": "progene_text",
"text": [
"The viruses in the genera Betatetravirus and Omegatetravirus of the Tetraviridae are clearly related but show significant differences in their genome organization ."
],
"offsets": [
[
0,
164
]
]
}
] | [] | [] | [] | [] |
split_0_train_314 | split_0_train_314 | [
{
"id": "split_0_train_314_passage",
"type": "progene_text",
"text": [
"It is concluded that the ancestral virus with a bipartite genome , as found in the genus Omegatetravirus , likely evolved from a virus with an unsegmented genome , as found in the genus Betatetravirus , through evolution of the subgenomic RNA into a separate genomic component , with the accompanying loss of the capsid gene from the longer genomic RNA ."
],
"offsets": [
[
0,
354
]
]
}
] | [
{
"id": "split_0_train_469_entity",
"type": "progene_text",
"text": [
"capsid gene"
],
"offsets": [
[
313,
324
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_315 | split_0_train_315 | [
{
"id": "split_0_train_315_passage",
"type": "progene_text",
"text": [
"The domain structure and retrotransposition mechanism of R2 elements are conserved throughout arthropods ."
],
"offsets": [
[
0,
106
]
]
}
] | [] | [] | [] | [] |
split_0_train_316 | split_0_train_316 | [
{
"id": "split_0_train_316_passage",
"type": "progene_text",
"text": [
"R2 elements are non - LTR retrotransposons that insert in the 28S rRNA genes of arthropods ."
],
"offsets": [
[
0,
92
]
]
}
] | [] | [] | [] | [] |
split_0_train_317 | split_0_train_317 | [
{
"id": "split_0_train_317_passage",
"type": "progene_text",
"text": [
"Partial sequence data from many species have previously suggested that these elements have been vertically inherited since the origin of this phylum ."
],
"offsets": [
[
0,
150
]
]
}
] | [] | [] | [] | [] |
split_0_train_318 | split_0_train_318 | [
{
"id": "split_0_train_318_passage",
"type": "progene_text",
"text": [
"Here , we compare the complete sequences of nine R2 elements selected to represent the diversity of arthropods ."
],
"offsets": [
[
0,
112
]
]
}
] | [] | [] | [] | [] |
split_0_train_319 | split_0_train_319 | [
{
"id": "split_0_train_319_passage",
"type": "progene_text",
"text": [
"All of the elements exhibited a uniform structure ."
],
"offsets": [
[
0,
51
]
]
}
] | [] | [] | [] | [] |
split_0_train_320 | split_0_train_320 | [
{
"id": "split_0_train_320_passage",
"type": "progene_text",
"text": [
"Identification of their conserved sequence features , combined with our biochemical studies , allows us to make the following inferences concerning the retrotransposition mechanism of R2 ."
],
"offsets": [
[
0,
188
]
]
}
] | [] | [] | [] | [] |
split_0_train_321 | split_0_train_321 | [
{
"id": "split_0_train_321_passage",
"type": "progene_text",
"text": [
"While all R2 elements insert into the identical sequence of the 28S gene , it is only the location of the initial nick in the target DNA that is rigidly conserved across arthropods ."
],
"offsets": [
[
0,
182
]
]
}
] | [] | [] | [] | [] |
split_0_train_322 | split_0_train_322 | [
{
"id": "split_0_train_322_passage",
"type": "progene_text",
"text": [
"Variation at the R2 5' junctions suggests that cleavage of the second strand of the target site is not conserved within or between species ."
],
"offsets": [
[
0,
140
]
]
}
] | [] | [] | [] | [] |
split_0_train_323 | split_0_train_323 | [
{
"id": "split_0_train_323_passage",
"type": "progene_text",
"text": [
"The extreme 5' and 3' ends of the elements themselves are also poorly conserved , consistent with a target primed reverse transcription mechanism for attachment of the 3' end and a template switch model for the attachment of the 5' end ."
],
"offsets": [
[
0,
237
]
]
}
] | [] | [] | [] | [] |
split_0_train_324 | split_0_train_324 | [
{
"id": "split_0_train_324_passage",
"type": "progene_text",
"text": [
"Comparison of the approximately 1,000-aa R2 ORF reveals that it can be divided into three domains ."
],
"offsets": [
[
0,
99
]
]
}
] | [] | [] | [] | [] |
split_0_train_325 | split_0_train_325 | [
{
"id": "split_0_train_325_passage",
"type": "progene_text",
"text": [
"The central 450 - aa domain can be folded by homology modeling into a tertiary structure resembling the fingers , palm , and thumb subdomains of retroviral reverse transcriptases ."
],
"offsets": [
[
0,
180
]
]
}
] | [
{
"id": "split_0_train_470_entity",
"type": "progene_text",
"text": [
"reverse transcriptases"
],
"offsets": [
[
156,
178
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_326 | split_0_train_326 | [
{
"id": "split_0_train_326_passage",
"type": "progene_text",
"text": [
"The carboxyl terminal end of the R2 protein appears to be the endonuclease domain , while the amino - terminal end contains zinc finger and c-myb - like DNA - binding motifs ."
],
"offsets": [
[
0,
175
]
]
}
] | [
{
"id": "split_0_train_471_entity",
"type": "progene_text",
"text": [
"endonuclease"
],
"offsets": [
[
62,
74
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_327 | split_0_train_327 | [
{
"id": "split_0_train_327_passage",
"type": "progene_text",
"text": [
"Direct comparison of the effects of CSF-1 ( M-CSF ) and GM-CSF on human monocyte DNA synthesis and CSF receptor expression ."
],
"offsets": [
[
0,
124
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]
}
] | [
{
"id": "split_0_train_472_entity",
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"text": [
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36,
41
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{
"id": "split_0_train_473_entity",
"type": "progene_text",
"text": [
"M-CSF"
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44,
49
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{
"id": "split_0_train_474_entity",
"type": "progene_text",
"text": [
"GM-CSF"
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56,
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},
{
"id": "split_0_train_475_entity",
"type": "progene_text",
"text": [
"CSF receptor"
],
"offsets": [
[
99,
111
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_328 | split_0_train_328 | [
{
"id": "split_0_train_328_passage",
"type": "progene_text",
"text": [
"There is evidence that a proportion of human monocytes can proliferate in vitro in response to colony - stimulating factor-1 ( CSF-1 , also known as M-CSF ) and granulocyte-macrophage CSF ( GM-CSF ) ."
],
"offsets": [
[
0,
200
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]
}
] | [
{
"id": "split_0_train_476_entity",
"type": "progene_text",
"text": [
"colony - stimulating factor-1"
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95,
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{
"id": "split_0_train_477_entity",
"type": "progene_text",
"text": [
"CSF-1"
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127,
132
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{
"id": "split_0_train_478_entity",
"type": "progene_text",
"text": [
"M-CSF"
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149,
154
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},
{
"id": "split_0_train_479_entity",
"type": "progene_text",
"text": [
"granulocyte-macrophage CSF"
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161,
187
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{
"id": "split_0_train_480_entity",
"type": "progene_text",
"text": [
"GM-CSF"
],
"offsets": [
[
190,
196
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_329 | split_0_train_329 | [
{
"id": "split_0_train_329_passage",
"type": "progene_text",
"text": [
"To determine whether there are differences in DNA synthesis responses to these CSF , a large study using purified human peripheral blood monocytes from 45 donors was performed under optimized culture conditions ."
],
"offsets": [
[
0,
212
]
]
}
] | [
{
"id": "split_0_train_481_entity",
"type": "progene_text",
"text": [
"CSF"
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"offsets": [
[
79,
82
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_330 | split_0_train_330 | [
{
"id": "split_0_train_330_passage",
"type": "progene_text",
"text": [
"In contrast to the consistent response to CSF-1 , approximately 20 % of donors have monocytes that do not respond or have a minimal DNA synthesis response to GM-CSF stimulation ."
],
"offsets": [
[
0,
178
]
]
}
] | [
{
"id": "split_0_train_482_entity",
"type": "progene_text",
"text": [
"CSF-1"
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42,
47
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],
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{
"id": "split_0_train_483_entity",
"type": "progene_text",
"text": [
"GM-CSF"
],
"offsets": [
[
158,
164
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_331 | split_0_train_331 | [
{
"id": "split_0_train_331_passage",
"type": "progene_text",
"text": [
"However , analysis demonstrated that no statistically significant differences exist in the levels of CSF-1 and GM-CSF - stimulated proliferation in monocytes ."
],
"offsets": [
[
0,
159
]
]
}
] | [
{
"id": "split_0_train_484_entity",
"type": "progene_text",
"text": [
"CSF-1"
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101,
106
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{
"id": "split_0_train_485_entity",
"type": "progene_text",
"text": [
"GM-CSF"
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"offsets": [
[
111,
117
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_332 | split_0_train_332 | [
{
"id": "split_0_train_332_passage",
"type": "progene_text",
"text": [
"In addition , CSF-1 receptor ( CSF-1R ) blocking experiments indicated that a proportion of the GM-CSF - induced DNA synthesis is due to endogenous levels of CSF-1 ."
],
"offsets": [
[
0,
165
]
]
}
] | [
{
"id": "split_0_train_486_entity",
"type": "progene_text",
"text": [
"CSF-1 receptor"
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14,
28
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],
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},
{
"id": "split_0_train_487_entity",
"type": "progene_text",
"text": [
"CSF-1R"
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31,
37
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],
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},
{
"id": "split_0_train_488_entity",
"type": "progene_text",
"text": [
"GM-CSF"
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96,
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{
"id": "split_0_train_489_entity",
"type": "progene_text",
"text": [
"CSF-1"
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"offsets": [
[
158,
163
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_333 | split_0_train_333 | [
{
"id": "split_0_train_333_passage",
"type": "progene_text",
"text": [
"As a further comparison of the actions of the two CSFs , CSF-1R and GM-CSFR levels were measured by flow cytometry , and it was shown that GM-CSFR levels decreased within 5 days of culture , independent of the conditions examined ."
],
"offsets": [
[
0,
231
]
]
}
] | [
{
"id": "split_0_train_490_entity",
"type": "progene_text",
"text": [
"CSFs"
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[
50,
54
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},
{
"id": "split_0_train_491_entity",
"type": "progene_text",
"text": [
"CSF-1R"
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57,
63
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{
"id": "split_0_train_492_entity",
"type": "progene_text",
"text": [
"GM-CSFR"
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68,
75
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],
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},
{
"id": "split_0_train_493_entity",
"type": "progene_text",
"text": [
"GM-CSFR"
],
"offsets": [
[
139,
146
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_334 | split_0_train_334 | [
{
"id": "split_0_train_334_passage",
"type": "progene_text",
"text": [
"In contrast , CSF-1R levels at day 5 approximated those measured in uncultured monocytes ."
],
"offsets": [
[
0,
90
]
]
}
] | [
{
"id": "split_0_train_494_entity",
"type": "progene_text",
"text": [
"CSF-1R"
],
"offsets": [
[
14,
20
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_335 | split_0_train_335 | [
{
"id": "split_0_train_335_passage",
"type": "progene_text",
"text": [
"Whether the proliferating subpopulation(s) express one or both CSF receptors at the beginning or at the end of culture is as yet unknown ."
],
"offsets": [
[
0,
138
]
]
}
] | [
{
"id": "split_0_train_495_entity",
"type": "progene_text",
"text": [
"CSF receptors"
],
"offsets": [
[
63,
76
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_336 | split_0_train_336 | [
{
"id": "split_0_train_336_passage",
"type": "progene_text",
"text": [
"The information obtained in this study will be useful for the design of strategies to enrich for the subpopulation in question based on CSF receptor expression ."
],
"offsets": [
[
0,
161
]
]
}
] | [
{
"id": "split_0_train_496_entity",
"type": "progene_text",
"text": [
"CSF receptor"
],
"offsets": [
[
136,
148
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_337 | split_0_train_337 | [
{
"id": "split_0_train_337_passage",
"type": "progene_text",
"text": [
"Steroidogenic factor-1 interacts with a gonadotrope - specific element within the first exon of the human gonadotropin - releasing hormone receptor gene to mediate gonadotrope - specific expression ."
],
"offsets": [
[
0,
199
]
]
}
] | [
{
"id": "split_0_train_497_entity",
"type": "progene_text",
"text": [
"Steroidogenic factor-1"
],
"offsets": [
[
0,
22
]
],
"normalized": []
},
{
"id": "split_0_train_498_entity",
"type": "progene_text",
"text": [
"gonadotropin - releasing hormone receptor"
],
"offsets": [
[
106,
147
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_338 | split_0_train_338 | [
{
"id": "split_0_train_338_passage",
"type": "progene_text",
"text": [
"GnRH plays a pivotal role in regulating human reproductive functions ."
],
"offsets": [
[
0,
70
]
]
}
] | [
{
"id": "split_0_train_499_entity",
"type": "progene_text",
"text": [
"GnRH"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_339 | split_0_train_339 | [
{
"id": "split_0_train_339_passage",
"type": "progene_text",
"text": [
"This hypothalamic peptide interacts with its receptor ( GnRHR ) on the pituitary gonadotropes to trigger the secretion of gonadotropins , which , in turn , regulates the release of sex steroids from the gonads ."
],
"offsets": [
[
0,
211
]
]
}
] | [
{
"id": "split_0_train_500_entity",
"type": "progene_text",
"text": [
"GnRHR"
],
"offsets": [
[
56,
61
]
],
"normalized": []
},
{
"id": "split_0_train_501_entity",
"type": "progene_text",
"text": [
"gonadotropins"
],
"offsets": [
[
122,
135
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_340 | split_0_train_340 | [
{
"id": "split_0_train_340_passage",
"type": "progene_text",
"text": [
"In light of the importance of GnRHR , the molecular mechanisms underlying the transcriptional regulation of the human GnRHR ( hGnRHR ) gene become a key issue in understanding human reproduction ."
],
"offsets": [
[
0,
196
]
]
}
] | [
{
"id": "split_0_train_502_entity",
"type": "progene_text",
"text": [
"GnRHR"
],
"offsets": [
[
30,
35
]
],
"normalized": []
},
{
"id": "split_0_train_503_entity",
"type": "progene_text",
"text": [
"GnRHR"
],
"offsets": [
[
118,
123
]
],
"normalized": []
},
{
"id": "split_0_train_504_entity",
"type": "progene_text",
"text": [
"hGnRHR"
],
"offsets": [
[
126,
132
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_341 | split_0_train_341 | [
{
"id": "split_0_train_341_passage",
"type": "progene_text",
"text": [
"In this report , the possible involvement of steriodogenic factor-1 ( SF-1 ) as a key cell - specific regulator for hGnRHR gene expression was examined ."
],
"offsets": [
[
0,
153
]
]
}
] | [
{
"id": "split_0_train_505_entity",
"type": "progene_text",
"text": [
"steriodogenic factor-1"
],
"offsets": [
[
45,
67
]
],
"normalized": []
},
{
"id": "split_0_train_506_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
70,
74
]
],
"normalized": []
},
{
"id": "split_0_train_507_entity",
"type": "progene_text",
"text": [
"hGnRHR"
],
"offsets": [
[
116,
122
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_342 | split_0_train_342 | [
{
"id": "split_0_train_342_passage",
"type": "progene_text",
"text": [
"By the transient luciferase reporter gene assays , the wild - type promoter , containing 2.3 kb ofthe hGnRHR gene 5' - flanking region relative to the ATG codon , was able to drive a 3.6 +/- 0.2 - fold ( P < 0.05 ) increase in luciferase activity in the mouse alphaT3-1 gonadotropes ."
],
"offsets": [
[
0,
284
]
]
}
] | [
{
"id": "split_0_train_508_entity",
"type": "progene_text",
"text": [
"luciferase"
],
"offsets": [
[
17,
27
]
],
"normalized": []
},
{
"id": "split_0_train_509_entity",
"type": "progene_text",
"text": [
"hGnRHR"
],
"offsets": [
[
102,
108
]
],
"normalized": []
},
{
"id": "split_0_train_510_entity",
"type": "progene_text",
"text": [
"luciferase"
],
"offsets": [
[
227,
237
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_343 | split_0_train_343 | [
{
"id": "split_0_train_343_passage",
"type": "progene_text",
"text": [
"Subsequent deletion analysis indicated that the most proximal 173 bp within the first exon of the gene , although not a promoter itself , contains a critical regulatory element(s) essential for the basal expression of the hGnRHR gene ."
],
"offsets": [
[
0,
235
]
]
}
] | [
{
"id": "split_0_train_511_entity",
"type": "progene_text",
"text": [
"hGnRHR"
],
"offsets": [
[
222,
228
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_344 | split_0_train_344 | [
{
"id": "split_0_train_344_passage",
"type": "progene_text",
"text": [
"The functional roles of the putative gonadotrope - specific elements ( GSE ; consensus 5' - CTG ( A ) / ( T ) CCTTG - 3' ) residing at positions - 5 , - 134 , and - 396 were studied by site - directed mutagenesis , and it was found that only the mutation at position - 134 significantly reduced the promoter activity ( 80 % reduction ; P < 0.05 ) ."
],
"offsets": [
[
0,
348
]
]
}
] | [] | [] | [] | [] |
split_0_train_345 | split_0_train_345 | [
{
"id": "split_0_train_345_passage",
"type": "progene_text",
"text": [
"The attenuation effect of this GSE mutant was cell specific , as it was restricted to alphaT3-1 cells , but not to COS-7 and human ovarian adenocarcinoma ( SKOV-3 ) cells ."
],
"offsets": [
[
0,
172
]
]
}
] | [] | [] | [] | [] |
split_0_train_346 | split_0_train_346 | [
{
"id": "split_0_train_346_passage",
"type": "progene_text",
"text": [
"Competitive mobility shift assays using either alphaT3-1 nuclear extract or recombinant SF-1 protein clearly indicated that SF-1 is able to interact specifically with this GSE element positioned at - 134 ."
],
"offsets": [
[
0,
205
]
]
}
] | [
{
"id": "split_0_train_512_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
88,
92
]
],
"normalized": []
},
{
"id": "split_0_train_513_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
124,
128
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_347 | split_0_train_347 | [
{
"id": "split_0_train_347_passage",
"type": "progene_text",
"text": [
"Using a SF-1 antibody that completely abrogated complex formation in the gel shift assays , the involvement of endogenous nuclear SF-1 was further evidenced ."
],
"offsets": [
[
0,
158
]
]
}
] | [
{
"id": "split_0_train_514_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
8,
12
]
],
"normalized": []
},
{
"id": "split_0_train_515_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
130,
134
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_348 | split_0_train_348 | [
{
"id": "split_0_train_348_passage",
"type": "progene_text",
"text": [
"By competitive gel shift assays using oligoprimers with 2 - bp scanning mutations , the sequences essential for the interaction with SF-1 were identified ( 5' - TTG ( A ) / ( T ) CCCTG-3' , underlined sequences were important ) ."
],
"offsets": [
[
0,
229
]
]
}
] | [
{
"id": "split_0_train_516_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
133,
137
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_349 | split_0_train_349 | [
{
"id": "split_0_train_349_passage",
"type": "progene_text",
"text": [
"To study the in vivo function of SF-1 , vector directing expression of sense or antisense SF-1 messenger RNA ( mRNA ) was cotransfected with the hGnRHR promoter - luciferase construct into alphaT3-1 , SKOV-3 , and COS-7 cells ."
],
"offsets": [
[
0,
227
]
]
}
] | [
{
"id": "split_0_train_517_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
33,
37
]
],
"normalized": []
},
{
"id": "split_0_train_518_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
90,
94
]
],
"normalized": []
},
{
"id": "split_0_train_519_entity",
"type": "progene_text",
"text": [
"hGnRHR"
],
"offsets": [
[
145,
151
]
],
"normalized": []
},
{
"id": "split_0_train_520_entity",
"type": "progene_text",
"text": [
"luciferase"
],
"offsets": [
[
163,
173
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_350 | split_0_train_350 | [
{
"id": "split_0_train_350_passage",
"type": "progene_text",
"text": [
"Overexpression of the SF-1 mRNA was able to enhance promoter activities in all of the cells tested ."
],
"offsets": [
[
0,
100
]
]
}
] | [
{
"id": "split_0_train_521_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
22,
26
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_351 | split_0_train_351 | [
{
"id": "split_0_train_351_passage",
"type": "progene_text",
"text": [
"On the contrary , expression of the antisense SF-1 mRNA reduced the hGnRHR promoter activity only in alphaT3-1 cells , not in COS-7 or SKOV-3 cells ."
],
"offsets": [
[
0,
149
]
]
}
] | [
{
"id": "split_0_train_522_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
46,
50
]
],
"normalized": []
},
{
"id": "split_0_train_523_entity",
"type": "progene_text",
"text": [
"hGnRHR"
],
"offsets": [
[
68,
74
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_352 | split_0_train_352 | [
{
"id": "split_0_train_352_passage",
"type": "progene_text",
"text": [
"In summary , the data reported here provide conclusive evidence that SF-1 interacts with the GSE motif at position - 134 within the first exon of the hGnRHR gene to mediate its cell - specific expression ."
],
"offsets": [
[
0,
205
]
]
}
] | [
{
"id": "split_0_train_524_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
69,
73
]
],
"normalized": []
},
{
"id": "split_0_train_525_entity",
"type": "progene_text",
"text": [
"hGnRHR"
],
"offsets": [
[
150,
156
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_353 | split_0_train_353 | [
{
"id": "split_0_train_353_passage",
"type": "progene_text",
"text": [
"Cd(II) - responsive and constitutive mutants implicate a novel domain in MerR ."
],
"offsets": [
[
0,
79
]
]
}
] | [
{
"id": "split_0_train_526_entity",
"type": "progene_text",
"text": [
"MerR"
],
"offsets": [
[
73,
77
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_354 | split_0_train_354 | [
{
"id": "split_0_train_354_passage",
"type": "progene_text",
"text": [
"Expression of the Tn21 mercury resistance ( mer ) operon is controlled by a metal - sensing repressor - activator , MerR ."
],
"offsets": [
[
0,
122
]
]
}
] | [
{
"id": "split_0_train_527_entity",
"type": "progene_text",
"text": [
"mercury resistance ( mer ) operon"
],
"offsets": [
[
23,
56
]
],
"normalized": []
},
{
"id": "split_0_train_528_entity",
"type": "progene_text",
"text": [
"MerR"
],
"offsets": [
[
116,
120
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_355 | split_0_train_355 | [
{
"id": "split_0_train_355_passage",
"type": "progene_text",
"text": [
"When present , MerR always binds to the same position on the DNA ( the operator merO ) , repressing transcription of the structural genes merTPCAD in the absence of Hg(II) and inducing their transcription in the presence of Hg(II) ."
],
"offsets": [
[
0,
232
]
]
}
] | [
{
"id": "split_0_train_529_entity",
"type": "progene_text",
"text": [
"MerR"
],
"offsets": [
[
15,
19
]
],
"normalized": []
},
{
"id": "split_0_train_530_entity",
"type": "progene_text",
"text": [
"merTPCAD"
],
"offsets": [
[
138,
146
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_356 | split_0_train_356 | [
{
"id": "split_0_train_356_passage",
"type": "progene_text",
"text": [
"Although it has two potential binding sites , the purified MerR homodimer binds only one Hg ( II ) ion , employing Cys82 from one monomer and Cys117 and Cys126 from the other ."
],
"offsets": [
[
0,
176
]
]
}
] | [
{
"id": "split_0_train_531_entity",
"type": "progene_text",
"text": [
"MerR"
],
"offsets": [
[
59,
63
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_357 | split_0_train_357 | [
{
"id": "split_0_train_357_passage",
"type": "progene_text",
"text": [
"When MerR binds Hg(II) , it changes allosterically and also distorts the merO DNA to facilitate transcriptional initiation by sigma70 RNA polymerase ."
],
"offsets": [
[
0,
150
]
]
}
] | [
{
"id": "split_0_train_532_entity",
"type": "progene_text",
"text": [
"MerR"
],
"offsets": [
[
5,
9
]
],
"normalized": []
},
{
"id": "split_0_train_533_entity",
"type": "progene_text",
"text": [
"sigma70"
],
"offsets": [
[
126,
133
]
],
"normalized": []
},
{
"id": "split_0_train_534_entity",
"type": "progene_text",
"text": [
"RNA polymerase"
],
"offsets": [
[
134,
148
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_358 | split_0_train_358 | [
{
"id": "split_0_train_358_passage",
"type": "progene_text",
"text": [
"Wild - type MerR is highly specific for Hg(II) and is 100 - and 1 , 000 - fold less responsive to the chemically related group 12 metals , Cd(II) and Zn(II) , respectively ."
],
"offsets": [
[
0,
173
]
]
}
] | [
{
"id": "split_0_train_535_entity",
"type": "progene_text",
"text": [
"MerR"
],
"offsets": [
[
12,
16
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_359 | split_0_train_359 | [
{
"id": "split_0_train_359_passage",
"type": "progene_text",
"text": [
"We sought merR mutants that respond to Cd(II) and obtained 11 Cd ( II ) - responsive and 5 constitutive mutants ."
],
"offsets": [
[
0,
113
]
]
}
] | [
{
"id": "split_0_train_536_entity",
"type": "progene_text",
"text": [
"merR"
],
"offsets": [
[
10,
14
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_360 | split_0_train_360 | [
{
"id": "split_0_train_360_passage",
"type": "progene_text",
"text": [
"The Cd ( II ) - responsive mutants , most of which had only single - residue replacements , were also repression deficient and still Hg ( II ) responsive but , like the wild type , were completely unresponsive to Zn(II) ."
],
"offsets": [
[
0,
221
]
]
}
] | [] | [] | [] | [] |
split_0_train_361 | split_0_train_361 | [
{
"id": "split_0_train_361_passage",
"type": "progene_text",
"text": [
"None of the Cd(II) - responsive mutations occurred in the DNA binding domain or replaced any of the key Cys residues ."
],
"offsets": [
[
0,
118
]
]
}
] | [] | [] | [] | [] |
split_0_train_362 | split_0_train_362 | [
{
"id": "split_0_train_362_passage",
"type": "progene_text",
"text": [
"Five Cd ( II ) - responsive single mutations lie in the antiparallel coiled - coil domain between Cys82 and Cys117 which constitutes the dimer interface ."
],
"offsets": [
[
0,
154
]
]
}
] | [] | [] | [] | [] |
split_0_train_363 | split_0_train_363 | [
{
"id": "split_0_train_363_passage",
"type": "progene_text",
"text": [
"These mutations identify 10 new positions whose alteration significantly affect MerR 's metal responsiveness or its repressor function ."
],
"offsets": [
[
0,
136
]
]
}
] | [
{
"id": "split_0_train_537_entity",
"type": "progene_text",
"text": [
"MerR"
],
"offsets": [
[
80,
84
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_364 | split_0_train_364 | [
{
"id": "split_0_train_364_passage",
"type": "progene_text",
"text": [
"They give rise to specific predictions for how MerR distinguishes group 12 metals , and they refine our model of the novel domain structure of MerR ."
],
"offsets": [
[
0,
149
]
]
}
] | [
{
"id": "split_0_train_538_entity",
"type": "progene_text",
"text": [
"MerR"
],
"offsets": [
[
47,
51
]
],
"normalized": []
},
{
"id": "split_0_train_539_entity",
"type": "progene_text",
"text": [
"MerR"
],
"offsets": [
[
143,
147
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_365 | split_0_train_365 | [
{
"id": "split_0_train_365_passage",
"type": "progene_text",
"text": [
"Secondary - structure predictions suggest that certain elements of this model also apply to other MerR family regulators ."
],
"offsets": [
[
0,
122
]
]
}
] | [
{
"id": "split_0_train_540_entity",
"type": "progene_text",
"text": [
"MerR family regulators"
],
"offsets": [
[
98,
120
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_366 | split_0_train_366 | [
{
"id": "split_0_train_366_passage",
"type": "progene_text",
"text": [
"Does perinatal phenobarbital exposure affect developmental outcome at age 2 ?"
],
"offsets": [
[
0,
77
]
]
}
] | [] | [] | [] | [] |
split_0_train_367 | split_0_train_367 | [
{
"id": "split_0_train_367_passage",
"type": "progene_text",
"text": [
"The objective of this paper is to determine if phenobarbital exposure during pregnancy affects developmental outcome at age 2 years ."
],
"offsets": [
[
0,
133
]
]
}
] | [] | [] | [] | [] |
split_0_train_368 | split_0_train_368 | [
{
"id": "split_0_train_368_passage",
"type": "progene_text",
"text": [
"Between 1991 and 1994 , 401 pregnant patients at risk for delivery prior to 34 weeks ' gestation were invited to participate ; 48 mothers declined entry ."
],
"offsets": [
[
0,
154
]
]
}
] | [] | [] | [] | [] |
split_0_train_369 | split_0_train_369 | [
{
"id": "split_0_train_369_passage",
"type": "progene_text",
"text": [
"Before delivery , pharmacy randomized the pregnant women to receive phenobarbital and vitamin K or identically appearing placebo in a blinded fashion ."
],
"offsets": [
[
0,
151
]
]
}
] | [] | [] | [] | [] |
split_0_train_370 | split_0_train_370 | [
{
"id": "split_0_train_370_passage",
"type": "progene_text",
"text": [
"Developmental follow - up at age 2 years was performed ."
],
"offsets": [
[
0,
56
]
]
}
] | [] | [] | [] | [] |
split_0_train_371 | split_0_train_371 | [
{
"id": "split_0_train_371_passage",
"type": "progene_text",
"text": [
"Children from the treatment group scored significantly lower on the Bayley Mental Developmental Index ( mean MDI +/- 1 SD ) than children whose mothers were randomized to the placebo group [ 104 +/- 21 ( n = 59 ) vs. 113 +/- 22 ( n = 62 ) , p = 0.023 ] ."
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0,
254
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]
}
] | [] | [] | [] | [] |
split_0_train_372 | split_0_train_372 | [
{
"id": "split_0_train_372_passage",
"type": "progene_text",
"text": [
"Of 36 independent variables , randomization group was one of five that individually contributed to the prediction of the Bayley MDI score ( p < 0.05 ) ."
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[
0,
152
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]
}
] | [] | [] | [] | [] |
split_0_train_373 | split_0_train_373 | [
{
"id": "split_0_train_373_passage",
"type": "progene_text",
"text": [
"It was concluded that perinatal phenobarbital therapy may impair developmental outcome ."
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0,
88
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]
}
] | [] | [] | [] | [] |
split_0_train_374 | split_0_train_374 | [
{
"id": "split_0_train_374_passage",
"type": "progene_text",
"text": [
"The phosphatidylinositol 3-phosphate binding protein Vac1p interacts with a Rab GTPase and a Sec1p homologue to facilitate vesicle - mediated vacuolar protein sorting ."
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0,
168
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}
] | [
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"Vac1p"
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53,
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{
"id": "split_0_train_542_entity",
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"text": [
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76,
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"type": "progene_text",
"text": [
"Sec1p"
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93,
98
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}
] | [] | [] | [] |
split_0_train_375 | split_0_train_375 | [
{
"id": "split_0_train_375_passage",
"type": "progene_text",
"text": [
"Activated GTP - bound Rab proteins are thought to interact with effectors to elicit vesicle targeting and fusion events ."
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0,
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}
] | [
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"type": "progene_text",
"text": [
"Rab"
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22,
25
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"normalized": []
}
] | [] | [] | [] |
split_0_train_376 | split_0_train_376 | [
{
"id": "split_0_train_376_passage",
"type": "progene_text",
"text": [
"Vesicle - associated v-SNARE and target membrane t - SNARE proteins are also involved in vesicular transport ."
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0,
110
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}
] | [
{
"id": "split_0_train_545_entity",
"type": "progene_text",
"text": [
"v-SNARE"
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21,
28
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{
"id": "split_0_train_546_entity",
"type": "progene_text",
"text": [
"t - SNARE"
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49,
58
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"normalized": []
}
] | [] | [] | [] |
split_0_train_377 | split_0_train_377 | [
{
"id": "split_0_train_377_passage",
"type": "progene_text",
"text": [
"Little is known about the functional relationship between Rabs and SNARE protein complexes ."
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0,
92
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}
] | [
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"id": "split_0_train_547_entity",
"type": "progene_text",
"text": [
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58,
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{
"id": "split_0_train_548_entity",
"type": "progene_text",
"text": [
"SNARE"
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67,
72
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_378 | split_0_train_378 | [
{
"id": "split_0_train_378_passage",
"type": "progene_text",
"text": [
"We have constructed an activated allele of VPS21 , a yeast Rab protein involved in vacuolar protein sorting , and demonstrated an allele - specific interaction between Vps21p and Vac1p ."
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"offsets": [
[
0,
186
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]
}
] | [
{
"id": "split_0_train_549_entity",
"type": "progene_text",
"text": [
"VPS21"
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43,
48
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{
"id": "split_0_train_550_entity",
"type": "progene_text",
"text": [
"Rab"
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59,
62
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{
"id": "split_0_train_551_entity",
"type": "progene_text",
"text": [
"Vps21p"
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168,
174
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{
"id": "split_0_train_552_entity",
"type": "progene_text",
"text": [
"Vac1p"
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[
179,
184
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_379 | split_0_train_379 | [
{
"id": "split_0_train_379_passage",
"type": "progene_text",
"text": [
"Vac1p was found to bind the Sec1p homologue Vps45p ."
],
"offsets": [
[
0,
52
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]
}
] | [
{
"id": "split_0_train_553_entity",
"type": "progene_text",
"text": [
"Vac1p"
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0,
5
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},
{
"id": "split_0_train_554_entity",
"type": "progene_text",
"text": [
"Sec1p"
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28,
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},
{
"id": "split_0_train_555_entity",
"type": "progene_text",
"text": [
"Vps45p"
],
"offsets": [
[
44,
50
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_380 | split_0_train_380 | [
{
"id": "split_0_train_380_passage",
"type": "progene_text",
"text": [
"Although no association between Vps21p and Vps45p was seen , a genetic interaction between VPS21 and VPS45 was observed ."
],
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[
0,
121
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]
}
] | [
{
"id": "split_0_train_556_entity",
"type": "progene_text",
"text": [
"Vps21p"
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32,
38
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{
"id": "split_0_train_557_entity",
"type": "progene_text",
"text": [
"Vps45p"
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43,
49
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"normalized": []
},
{
"id": "split_0_train_558_entity",
"type": "progene_text",
"text": [
"VPS21"
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91,
96
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"normalized": []
},
{
"id": "split_0_train_559_entity",
"type": "progene_text",
"text": [
"VPS45"
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"offsets": [
[
101,
106
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_381 | split_0_train_381 | [
{
"id": "split_0_train_381_passage",
"type": "progene_text",
"text": [
"Vac1p contains a zinc - binding FYVE finger that may bind phosphatidylinositol 3-phosphate [ PtdIns(3)P ] ."
],
"offsets": [
[
0,
107
]
]
}
] | [
{
"id": "split_0_train_560_entity",
"type": "progene_text",
"text": [
"Vac1p"
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"offsets": [
[
0,
5
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_382 | split_0_train_382 | [
{
"id": "split_0_train_382_passage",
"type": "progene_text",
"text": [
"In other FYVE domain proteins , this motif and PtdIns(3)P are necessary for membrane association ."
],
"offsets": [
[
0,
98
]
]
}
] | [] | [] | [] | [] |
split_0_train_383 | split_0_train_383 | [
{
"id": "split_0_train_383_passage",
"type": "progene_text",
"text": [
"Vac1 proteins with mutant FYVE fingers still associated with membranes but showed vacuolar protein sorting defects and reduced interactions with Vps45p and activated Vps21p ."
],
"offsets": [
[
0,
174
]
]
}
] | [
{
"id": "split_0_train_561_entity",
"type": "progene_text",
"text": [
"Vac1"
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"offsets": [
[
0,
4
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],
"normalized": []
},
{
"id": "split_0_train_562_entity",
"type": "progene_text",
"text": [
"Vps45p"
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"offsets": [
[
145,
151
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"normalized": []
},
{
"id": "split_0_train_563_entity",
"type": "progene_text",
"text": [
"Vps21p"
],
"offsets": [
[
166,
172
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_384 | split_0_train_384 | [
{
"id": "split_0_train_384_passage",
"type": "progene_text",
"text": [
"Vac1p membrane association was not dependent on PtdIns(3)P , Pep12p , Vps21p , Vps45p , or the PtdIns 3-kinase , Vps34p ."
],
"offsets": [
[
0,
121
]
]
}
] | [
{
"id": "split_0_train_564_entity",
"type": "progene_text",
"text": [
"Vac1p"
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"offsets": [
[
0,
5
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],
"normalized": []
},
{
"id": "split_0_train_565_entity",
"type": "progene_text",
"text": [
"Pep12p"
],
"offsets": [
[
61,
67
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],
"normalized": []
},
{
"id": "split_0_train_566_entity",
"type": "progene_text",
"text": [
"Vps21p"
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"offsets": [
[
70,
76
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"normalized": []
},
{
"id": "split_0_train_567_entity",
"type": "progene_text",
"text": [
"Vps45p"
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"offsets": [
[
79,
85
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],
"normalized": []
},
{
"id": "split_0_train_568_entity",
"type": "progene_text",
"text": [
"PtdIns 3-kinase"
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"offsets": [
[
95,
110
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],
"normalized": []
},
{
"id": "split_0_train_569_entity",
"type": "progene_text",
"text": [
"Vps34p"
],
"offsets": [
[
113,
119
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_385 | split_0_train_385 | [
{
"id": "split_0_train_385_passage",
"type": "progene_text",
"text": [
"Vac1p FYVE finger mutant missorting phenotypes were suppressed by a defective allele of VPS34 ."
],
"offsets": [
[
0,
95
]
]
}
] | [
{
"id": "split_0_train_570_entity",
"type": "progene_text",
"text": [
"Vac1p"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_571_entity",
"type": "progene_text",
"text": [
"VPS34"
],
"offsets": [
[
88,
93
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_386 | split_0_train_386 | [
{
"id": "split_0_train_386_passage",
"type": "progene_text",
"text": [
"These data indicate that PtdIns(3)P may perform a regulatory role , possibly involved in mediating Vac1p protein - protein interactions ."
],
"offsets": [
[
0,
137
]
]
}
] | [
{
"id": "split_0_train_572_entity",
"type": "progene_text",
"text": [
"Vac1p"
],
"offsets": [
[
99,
104
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_387 | split_0_train_387 | [
{
"id": "split_0_train_387_passage",
"type": "progene_text",
"text": [
"We propose that activated - Vps21p interacts with its effector , Vac1p , which interacts with Vps45p to regulate the Golgi to endosome SNARE complex ."
],
"offsets": [
[
0,
150
]
]
}
] | [
{
"id": "split_0_train_573_entity",
"type": "progene_text",
"text": [
"Vps21p"
],
"offsets": [
[
28,
34
]
],
"normalized": []
},
{
"id": "split_0_train_574_entity",
"type": "progene_text",
"text": [
"Vac1p"
],
"offsets": [
[
65,
70
]
],
"normalized": []
},
{
"id": "split_0_train_575_entity",
"type": "progene_text",
"text": [
"Vps45p"
],
"offsets": [
[
94,
100
]
],
"normalized": []
},
{
"id": "split_0_train_576_entity",
"type": "progene_text",
"text": [
"SNARE"
],
"offsets": [
[
135,
140
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_388 | split_0_train_388 | [
{
"id": "split_0_train_388_passage",
"type": "progene_text",
"text": [
"Contrast enhanced pulsed Doppler and colour - coded duplex studies of the cranial vasculature ."
],
"offsets": [
[
0,
95
]
]
}
] | [] | [] | [] | [] |
split_0_train_389 | split_0_train_389 | [
{
"id": "split_0_train_389_passage",
"type": "progene_text",
"text": [
"INTRODUCTION :"
],
"offsets": [
[
0,
14
]
]
}
] | [] | [] | [] | [] |
split_0_train_390 | split_0_train_390 | [
{
"id": "split_0_train_390_passage",
"type": "progene_text",
"text": [
"The aim of this study was to assess the effect of Albunex , a vascular contrast agent based on albumin - coated air microbubbles , on pulsed Doppler and colour - coded duplex sonography of the cranial vasculature ."
],
"offsets": [
[
0,
214
]
]
}
] | [
{
"id": "split_0_train_577_entity",
"type": "progene_text",
"text": [
"albumin"
],
"offsets": [
[
95,
102
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_391 | split_0_train_391 | [
{
"id": "split_0_train_391_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
] | [] | [] | [] | [] |
split_0_train_392 | split_0_train_392 | [
{
"id": "split_0_train_392_passage",
"type": "progene_text",
"text": [
"Twenty healthy male volunteers received intravenous injections of contrast in single doses ranging from 0.08 to 0.30 ml / kg ."
],
"offsets": [
[
0,
126
]
]
}
] | [] | [] | [] | [] |
split_0_train_393 | split_0_train_393 | [
{
"id": "split_0_train_393_passage",
"type": "progene_text",
"text": [
"Pulsed wave Doppler sonography examination and colour - coded duplex sonography were carried out in the right internal carotid artery ( ICA ) and middle cerebral artery ( MCA ) before and after i.v. contrast ."
],
"offsets": [
[
0,
209
]
]
}
] | [] | [] | [] | [] |
split_0_train_394 | split_0_train_394 | [
{
"id": "split_0_train_394_passage",
"type": "progene_text",
"text": [
"The relative intensity increase of the Doppler signal was measured in decibels ."
],
"offsets": [
[
0,
80
]
]
}
] | [] | [] | [] | [] |
split_0_train_395 | split_0_train_395 | [
{
"id": "split_0_train_395_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] | [] | [] | [] | [] |
split_0_train_396 | split_0_train_396 | [
{
"id": "split_0_train_396_passage",
"type": "progene_text",
"text": [
"Transpulmonary passage of contrast occurred in sufficient amounts to enhance the intensity of the Doppler signal significantly , but the duration of this effect was short ."
],
"offsets": [
[
0,
172
]
]
}
] | [] | [] | [] | [] |
split_0_train_397 | split_0_train_397 | [
{
"id": "split_0_train_397_passage",
"type": "progene_text",
"text": [
"Contrast enhancement also improved visualization of both the ICA and MCA in all subjects ."
],
"offsets": [
[
0,
90
]
]
}
] | [] | [] | [] | [] |
split_0_train_398 | split_0_train_398 | [
{
"id": "split_0_train_398_passage",
"type": "progene_text",
"text": [
"For the transcranial examinations , this resulted in visualization of a greater length of the middle cerebral arteries and additional vessels in the Circle of Willis ."
],
"offsets": [
[
0,
167
]
]
}
] | [] | [] | [] | [] |
split_0_train_399 | split_0_train_399 | [
{
"id": "split_0_train_399_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
] | [] | [] | [] | [] |