nopperl/pmc-image-text · Datasets at Hugging Face

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0.474289	3c009e8742554ad28ae266b6625861fe	Effect of nitrogen deficiency on gene expression in peanut roots. Statistical analysis of DEGs during nitrogen deficiency treatment for 5 and 10 days. (A) The number of significantly upregulated and downregulated expressed genes; (B) Venn diagrams of DEGs from two root comparisons; (C) heatmap of overlapped DEGs in HNR05 vs. LNR05 and HNR10 vs. LNR10 comparisons.	PMC9960604	plants-12-00732-g004.jpg
0.477903	145ff8c7adf84e208e2c499c54cc33b8	GO annotation terms of DEGs from HNR05 vs. LNR05 and HNR10 vs. LNR10.	PMC9960604	plants-12-00732-g005.jpg
0.423044	4cbcb4f474f246c18453c509cf568550	DEGs participated in nitrate transportation and assimilation. (A) Heatmap of DEGs related to nitrate transportation and assimilation. I: HNR05 vs. LNR05; II: HNR10 vs. LNR10. (B) Nitrate transportation and assimilation process in HNR10 vs. LNR10. For each rectangular shape, red shapes represent upregulated DEGs, while blue shapes represent downregulated DEGs.	PMC9960604	plants-12-00732-g006.jpg
0.38247	e22abf482feb484aa445dd9adf9e0e62	DEGs related to plant hormone signal transduction. (A) Heatmap of DEGs related to plant hormone signal transduction pathways. I: HNR05 vs. LNR05; II: HNR10 vs. LNR10. (B) Plant hormone signal transduction process in HNR10 vs. LNR10. For each rectangular shape, red shapes represent upregulated DEGs, while blue shapes represent downregulated DEGs.	PMC9960604	plants-12-00732-g007.jpg
0.490915	a689f06e2ec04c9fb87191ccd3018ba6	DEGs participated in lignin biosynthetic pathway. (A) Heatmap of DGs related to lignin biosynthetic pathway. I: HNR05 vs. LNR05; II: HNR10 vs. LNR10; (B) lignin biosynthetic pathway in HNR10 vs. LNR10. For each rectangular shape, red shapes represent upregulated DEGs, while blue shapes represent downregulated DEGs.	PMC9960604	plants-12-00732-g008.jpg
0.447325	66db863855994229966d2e571e5c5565	Predicted protein–protein interaction networks of all DEPs in roots under 10 days of nitrogen deficiency. Red hexagons represent upregulated DEPs; green hexagons represent downregulated DEPs. The full names of all the abbreviations above are shown in Table S12.	PMC9960604	plants-12-00732-g009.jpg
0.405422	0e3c750500a34b08856b25fcb7445323	A proposed model for the mechanism underlying the inhibition of peanut roots by nitrogen deficiency. Notes: Red arrows represent upregulated and green arrows represent downregulated genes. ABA: abscisic acid; CAD: Cinnamyl alcohol dehydrogenase; 4CL: 4-coumarate--CoA ligase; NRT1.1: nitrate transporter 1.1; NRT1.2: nitrate transporter1.2; PLA: phenylalanine ammonia-lyase; POD: peroxidase; PP2C: phosphatase 2C.	PMC9960604	plants-12-00732-g010.jpg
0.448083	89a7e2aa28b7420e8b1b9c9d3759f78c	Pipeline of performed data consolidation.	PMC9961470	ijms-24-04011-g001.jpg
0.438427	dde40de7185d4b65b7d3eafff74d6c44	Multiple sequence alignment of 9930, Gy14, and B10v3 genomes of data from CuGenDBv2 database. The red vertical lines indicate the boundaries of the individual chromosomes, which have been signed according to the numbering in each genome. Colored boxes represent common elements between the compared genomes, and grey areas are unique to the depicted genome.	PMC9961470	ijms-24-04011-g002.jpg
0.450771	6dfedecb5cee4b1b9eeda55e6d69be29	Comparison of arrangement tools: RagTag, Mauve Contig Mover, Multi-CSAR. As a reference 9930 genome was used. Colored boxes represent common elements between the compared genomes, and grey areas are unique to the depicted genome. The red vertical lines indicate the boundaries of the individual chromosomes.	PMC9961470	ijms-24-04011-g003.jpg
0.478813	580b14de0ab848ffbe582f54c712a1c8	RagTag result of B10v3 genome rearrangement and assigned to chromosome with use of filtered 9930 reference genome visualized in Mauve software. The red vertical lines indicate the boundaries of the individual chromosomes.	PMC9961470	ijms-24-04011-g004.jpg
0.477097	dc877a92028a4956a326e688bd1b1f3f	RagTag result of B10v3 rearrangement using filtered Gy14 reference and assigned to chromosome visualized in Mauve software. The red vertical lines indicate the boundaries of the individual chromosomes.	PMC9961470	ijms-24-04011-g005.jpg
0.455666	452bc4226a3141298ec5f49c1573b064	Comparative and corresponding B10 numbering (upper) to 9930/Gy14 numbering (down). Chromosome number (Ch) according to Han et al. [21] and Yang et al. [3] work. Karyotype of B10 showed FISH signals (left) and sequential DAPI and CMA staining (right). Karyotype of 9930 and Gy14 showed only FISH signals. The arrows indicate the chromosome equivalent of the B10v3 version (upper) vs. 9930 and Gy14 (down).	PMC9961470	ijms-24-04011-g006.jpg
0.439887	3c2ba2d0f4ec43b1a28183a8104e79ac	Probe localization on three cucumber line chromosomes: B10, 859, and CSH55. (A) DAPI staining, (B) CMA staining, (C) Type IV (red) and 45S rDNA (green), and (D) Type III (orange) and Type IV (red). Scale bar = 5 μm.	PMC9961470	ijms-24-04011-g007.jpg
0.417958	2fd9cb538c0949738e661254fbc6527d	Exosome extraction from human plasma and lysis to release target molecules. Colorimetric responses of PT upon the addition of PNA and various concentrations of the mir21-spiked exosomes.	PMC9962048	molecules-28-01909-g001.jpg
0.424047	f1371e8e66694251b419aba6df62922c	Electron microscopy images of exosome sample (a) before lysis (as indicated by the white arrow that shows an exosome) and (b) after lysis (as indicated in the white box whereby the vesicles have been ruptured).	PMC9962048	molecules-28-01909-g002.jpg
0.428138	0749b85e558c40f58ef5a3bd3aa29ee2	Size distribution spectrum of (a) exosome sample before lysis, (b) exosome sample after lysis, and (c) 0.1% Triton X-100.	PMC9962048	molecules-28-01909-g003.jpg
0.454113	c339665d1c404c85b6943108cabc13e6	Colorimetric responses (digital images) of varying amounts (1×, 10×, 0×) of (a) exosomes with PT in MilliQ in Vials A–C, (b) exosomes with PT in PBS in Vials D–F, and (c) exosomes with PT-T20 in PBS in Vials G–I, and their corresponding fluorescence spectra (d–f), respectively.	PMC9962048	molecules-28-01909-g004.jpg
0.490521	38bd15a3a3dc4f73ab89e79860a24c55	Melting curve of mir21 expression (20 cycles).	PMC9962048	molecules-28-01909-g005.jpg
0.397477	8741aeaa24b84aaeb7c35371ee2d0c35	mir21 assay (a–d): (a) digital images of vials containing (A) PT-T20-PNA1-1 μM mir21 (control), and (B–F) PT-T20 with 4 μM, 2 μM, 1 μM, 500 nM and 250 nM mir21 and, (b) corresponding fluorescence spectra, (c) ΔE values calculated with respect to vial A and (d) linear plot of mir21 concentration versus normalized fluorescence intensity.	PMC9962048	molecules-28-01909-g006.jpg
0.448175	814568d1d0924a4eae0efcc497249f2d	Association of fetuin-A at T0 (a) and at T24 (b).	PMC9962253	ijms-24-03203-g001.jpg
0.487086	cf20fdb0962641f09a3be99af8446815	Scatterplot: Association of Fetuin-A at T0 and of mNY at T0.	PMC9962253	ijms-24-03203-g002.jpg
0.461634	d7af42d2e8a04531a895b8ef0b40bacf	Scatterplot: Association of Fetuin-A at T24 and of mNY at T24.	PMC9962253	ijms-24-03203-g003.jpg
0.512912	273df3fd17b44089a888f76cb2dfc5e6	Scatterplot: Association of Fetuin-A at T0 and of mNY at T24.	PMC9962253	ijms-24-03203-g004.jpg
0.39046	6495431fc81944d6876d23e8a3d33433	Correlations between serum 25(OH)D concentration and (A) BMI, (B) muscle mass, (C) fat mass, and (D) PTH levels in LDD patients. r: Spearman’s coefficient, statistically significant at p < 0.05.	PMC9962334	ijms-24-03152-g001.jpg
0.420713	3224b135c7344dccb2ce379bb30196e5	Evaluation of gait speed physical performance: (A) Comparison of gait speed between patients with vitamin D sufficiency and insufficiency. p-value was calculated with the Mann–Whitney U test. (B) Comparison of gait speed between patients, classified by ODI score. p-value was evaluated by Friedman’s two-way analysis of variance (ANOVA) test. (C) Correlation between serum 25(OH)D and gait speed.	PMC9962334	ijms-24-03152-g002.jpg
0.413102	ce1e41b9f5f946a28732f49222663053	Determination of chair stand test: (A) Comparison of chair stand test between patients with vitamin D sufficiency and insufficiency. p-value was calculated with the Mann–Whitney U test. (B) Comparison of chair stand test between patients, classified by ODI score. p-value was examined using Friedman’s two-way ANOVA test. (C) Correlation between serum 25(OH)D and the time in chair stand test.	PMC9962334	ijms-24-03152-g003.jpg
0.408672	ce52f7ad877844aca18bdf546e0cce3c	Determination of TUG test: (A) Comparison of TUG test between patients with vitamin D sufficiency and insufficiency. p-value was analyzed using the Mann–Whitney U test. (B) Comparison of TUG test between patients, classified by ODI score. p-value was calculated with Friedman’s two-way ANOVA test. (C) Correlation between serum 25(OH)D and the time in the TUG test.	PMC9962334	ijms-24-03152-g004.jpg
0.463789	766cbd87c05b4907ab3d85965cdff0ee	Schematic illustration of nasal end-tidal carbon dioxide (PetCO2) and transcutaneous carbon dioxide (PtcCO2) monitoring. An end-tidal sample line was inserted into the nasopharyngeal airway to monitor PetCO2. A transcutaneous monitoring probe was placed on the forearm ipsilateral to the non-operated lung to monitor PtcCO2.	PMC9962657	jcm-12-01706-g001.jpg
0.500659	4716714ab8ff430082eef5387a0a4479	The receiver operating characteristic (ROC) curves comparing the predictive power of PtcCO2 and PetCO2 monitoring for hypercapnia (PaCO2 > 60 mmHg). PetCO2, end-tidal carbon dioxide partial pressure; PtcCO2, transcutaneous carbon dioxide partial pressure; PaCO2, partial pressure of arterial carbon dioxide.	PMC9962657	jcm-12-01706-g002.jpg
0.461035	79563d81fedb4ab7bc719fc1002000e6	Correlation of PtcCO2 and PetCO2 with PaCO2 during (a) two-lung ventilation and (b) one-lung ventilation. PetCO2, end-tidal carbon dioxide partial pressure; PtcCO2, transcutaneous carbon dioxide partial pressure; PaCO2, partial pressure of arterial carbon dioxide.	PMC9962657	jcm-12-01706-g003.jpg
0.512625	9566a386b3aa4f4c9ee7304dba4c40a5	Bland–Altman plots comparing the agreement between (a) PaCO2 and PtcCO2 and (b) PaCO2 and PetCO2 during two-lung ventilation. PetCO2, end-tidal carbon dioxide partial pressure; PtcCO2, transcutaneous carbon dioxide partial pressure; PaCO2, partial pressure of arterial carbon dioxide; SD, standard deviation.	PMC9962657	jcm-12-01706-g004a.jpg
0.443027	2534b55caaea454881415ba1281c7da8	Bland–Altman plots comparing the agreement between (a) PaCO2 and PtcCO2 and (b) PaCO2 and PetCO2 during one-lung ventilation. PetCO2, end-tidal carbon dioxide partial pressure; PtcCO2, transcutaneous carbon dioxide partial pressure; PaCO2, partial pressure of arterial carbon dioxide; SD, standard deviation.	PMC9962657	jcm-12-01706-g005.jpg
0.486843	2f7c12ba7e4e479a8fc4ff0c919e92b3	Structures of isolated compounds 1−20 from V. rotundifolia.	PMC9962727	metabolites-13-00249-g001.jpg
0.455182	ae6be27728e94cf2bc92ee56f80c2477	CD spectrum (A) and key HMBC, COSY, 1D NOE, and NOESY (B) correlations of compound 1.	PMC9962727	metabolites-13-00249-g002.jpg
0.368086	b73cc5e55bfb47f4936616184f671990	Modified Mosher’s method.	PMC9962727	metabolites-13-00249-g003.jpg
0.393986	b3f0659f4cd848099f30dd3742b37b4f	Antioxidant effect of compounds (1−20). The DPPH assay was performed in triplicate. The data are represented as mean ± SD. * p < 0.05, compared to control (CON).	PMC9962727	metabolites-13-00249-g004.jpg
0.419122	914090283e154fc3acb92d5e2ac62f96	Cytotoxic effects (A) and NO production inhibitory effects (B) of isolated compounds (1−20 at 10 and 100 μM) in LPS-stimulated RAW264.7 cells. RAW264.7 cells were treated with compounds 1−20 (10 and 100 µM) for 1 h and stimulated with LPS (1 μg/mL) for 16 h. (A) The viability of cells was determined using an MTT assay. (B) The level of NO production in serum-free culture medium was measured. Both experiments were performed in triplicate. The data are represented as mean ± SD. p < 0.05, *p < 0.01, compared to the LPS-treated group.	PMC9962727	metabolites-13-00249-g005.jpg
0.412946	a0eaaa1e83f340f4b0ea4d1ea7fefb13	Cytotoxic effects (A) and IL-8 production inhibitory effects (B) of compounds in LPS-induced HT-29 cells. HT-29 cells were treated with compounds 1−20 (10 and 100 µM) for 2 h and stimulated with LPS (100 ng/mL) for 12 h. (A) The viability of cells was determined using an MTT assay. (B) The level of IL-8 in the culture media was measured with an ELISA kit. The values are expressed as mean ± standard deviation of three individual experiments. * p < 0.05, ** p < 0.01, compared to the LPS-treated group.	PMC9962727	metabolites-13-00249-g006.jpg
0.451351	665f9a9dc8044c45a38146d87eac8f28	Binding poses and interactions between binding sites of the IL-8 receptor with respect to ligands (compounds 8 (A), 9 (B), 13 (C), 14 (D), and 19 (E)).	PMC9962727	metabolites-13-00249-g007.jpg
0.391598	3f05b587fe0046c793a28e1c457689a4	Map of Tehran, Iran, showing the spatial distribution of COVID-19 mortality 2019–2021; EBS = empirical Bayes smoothed mortality rates per 100,000 population at the neighbourhood level. Numbers indicate the administrative district division of the city. Each district includes some neighbourhoods.	PMC9962969	tropicalmed-08-00085-g001.jpg
0.404886	ad4ea7cf06b4414993dbd560a1e2622a	Spatial distributions for selected explanatory variables in Tehran, Iran. Dark blue shades show low ranges and dark red shades show high range values for each variable (numbers as given in Table 1).	PMC9962969	tropicalmed-08-00085-g002.jpg
0.463268	2d0a6c04226d4d2e86cae4c97b8ea1e5	Methodology flowchart of the study of COVID-19 mortality in Tehran.	PMC9962969	tropicalmed-08-00085-g003.jpg
0.423131	dba4704fb8ab4a759fdc44acf34ae3e1	(a): Monthly distribution chart of the mortality rates (per 100,000 population) by number and sex; (b): percentage of COVID-19 related deaths by number, sex, and age group.	PMC9962969	tropicalmed-08-00085-g004.jpg
0.419958	db74a7bd49fe4f77bb208fa994522e0f	Purely temporal significant clusters of COVID-19 deaths during 2019 to 2021 in the study area.	PMC9962969	tropicalmed-08-00085-g005.jpg
0.45766	ce795ce77c124297871fac99dbd7de07	Detected purely spatial clusters of COVID-19 deaths in Tehran, Iran.	PMC9962969	tropicalmed-08-00085-g006.jpg
0.458869	57c3c9e60afa40fda11529ac678b0447	Detected space-time clusters of COVID-19 deaths in Tehran, Iran.	PMC9962969	tropicalmed-08-00085-g007.jpg
0.446822	899824fb7d564166ab5fb45855214e98	Spatial distribution of local R2 values for GWR and MGWR models. (A): Map of the GWR local R2 values, (B): Map of the MGWR local R2 values, (C): Histogram chart depicting the distribution of GWR R2 values; and (D): Histogram chart depicting the distribution of MGWR R2 values in the study area.	PMC9962969	tropicalmed-08-00085-g008.jpg
0.409697	5f7b5f7518f84806a6a00ee9b1f741e4	Surface map of local estimates pseudo t-values of MGWR model results for Tehran’s COVID-19 mortality rate dataset. Dark blue shades show areas with high t-values. All maps were generated in ArcGIS Pro 3.0.2 (ESRI, Redlands, CA, USA, 2022).	PMC9962969	tropicalmed-08-00085-g009.jpg
0.454927	57c6ae9247f0439886286f005e8bb93d	Spatial distribution bivariate map of local estimates (Beta) and covariates original values of MGWR model results for Tehran’s COVID-19 mortality rates. All the maps were generated in ArcGIS Pro 3.0.2 (ESRI, Redlands, CA, USA, 2022).	PMC9962969	tropicalmed-08-00085-g010.jpg
0.504633	d4fdfc56a29a4ebcb8c05dfe8a4d0b95	Co-pyrolysis of C4 hydrocarbons and hexane: conversion of C4 hydrocarbons (●1-butene; ● 2-butene; ● isobutane; ● butane; and ● isobutene) in dependence on their mole fraction in the binary mixture. Points represent experimental data and lines were obtained from regression analysis.	PMC9962995	materials-16-01418-g001.jpg
0.414386	0e9f89ac523546d2b7bb25cbf24775ae	Co-pyrolysis of C4 hydrocarbons and cyclohexane: conversion of C4 hydrocarbons (●1-butene; ● 2-butene; ● isobutane; ● butane; and ● isobutene) in dependence on their mole fraction in the binary mixture. Points represent experimental data and lines were obtained from regression analysis.	PMC9962995	materials-16-01418-g002.jpg
0.473626	cfcdfe46bdb04e6dab260e4fe71853f7	Co-pyrolysis of C4 hydrocarbons and 3-methylpentane: conversion of C4 hydrocarbons (○ 2-butene and ● isobutene) in dependence on their mole fraction in the binary mixture. Points represent experimental data; solid line was obtained from regression analysis and dashed line is a simulation.	PMC9962995	materials-16-01418-g003.jpg
0.465837	6b0ee8c6f2a74f1f9909654a406662eb	Co-pyrolysis of C4 hydrocarbons and heptane: conversion of C4 hydrocarbons (○ 2-butene and ● isobutene) in dependence on their mole fraction in the binary mixture. Points represent experimental data; solid line was obtained from regression analysis and dashed line is a simulation.	PMC9962995	materials-16-01418-g004.jpg
0.435774	c3c469bb11814ee9ba90925561e80442	3D visualization of snack pellets and crisps expanded by selected methods: P—unexpanded pellets, F—crisps expanded by frying in deep oil, M—crisps expanded by microwaving, A—crisps expanded by hot-air toasting, 0–30 amount of fresh carrot pulp (%).	PMC9963299	materials-16-01541-g001.jpg
0.398699	043d99bc4fa944a7ba85535528ca2c16	Cross-section of snack pellets and crisps expanded by selected methods: P—unexpanded pellets, F—crisps expanded by frying in deep oil, M—crisps expanded by microwaving, A—crisps expanded by hot-air toasting, 0–30 amount of fresh carrot pulp (%).	PMC9963299	materials-16-01541-g002.jpg
0.440455	62cce49ed51f4e4f9a83740536f9497d	Pore size and wall thickness distribution in snack pellets and crisps expanded by selected methods: P—unexpanded pellets, F—crisps expanded by frying in deep oil, M—crisps expanded by microwave, A—crisps expanded by hot-air toasting, 0–30 amount of fresh carrot pulp (%).	PMC9963299	materials-16-01541-g003.jpg
0.391394	13a0ff4b13944d4a90e8832014346d1c	PCA analysis of snack pellets and expanded crisps features.	PMC9963299	materials-16-01541-g004.jpg
0.465369	8a0a187ac08140a8b051625a5c617c57	The crisps objects in space of first two major components by PCA (principal component analysis) (a), and the dendrogram obtained by HCA (hierarchical cluster analysis) application (b). F—crisps expanded by frying in deep oil, M—crisps expanded by microwave, A—crisps expanded by hot-air toasting, 0–30 amount of fresh carrot pulp (%); different colors of circles mean similar homogenous groups.	PMC9963299	materials-16-01541-g005.jpg
0.473352	f2e4eb197fa142f68f17e71932398e75	Structures of the peptide leads GE11, D4, CPP, P1, P2, EGBP, Pep11, QRH and hEGF of which chelator-modified and radiolabeled analogs were developed of and tested for their potential to be applied as agents for EGFR-specific tumor targeting. In the structure of hEGF, the three loops of the peptide are colored in red (A loop), blue (B loop) and green (C loop), while the part of the peptide belonging to both the A and the B loop is depicted in purple.	PMC9963887	pharmaceuticals-16-00273-g001.jpg
0.404985	2e43f7c170e4425d9e659fd9637a7aac	Structures of the N-terminally PEG5-NODA-GA-modified labeling precursors based on the peptides GE11 (1), D4 (2), P1 (3) and P2 (4).	PMC9963887	pharmaceuticals-16-00273-g002.jpg
0.451313	877f96dd84474337b3db3e63b00f1395	Structures of the C-terminally PEG5-NODA-GA-modified labeling precursors based on the peptides QRH (5), CPP (6), EGBP (7), the three loops of the hEGF (8–10) and Pep11 (11).	PMC9963887	pharmaceuticals-16-00273-g003.jpg
0.473546	d09a9ba47549465ebe67df5008e9e2c7	Analytical radio-HPLC chromatograms of [68Ga]Ga-1–[68Ga]Ga-11 as obtained directly after radiolabeling of 1–11 with 68Ga3+.	PMC9963887	pharmaceuticals-16-00273-g004.jpg
0.48269	a19601df0fad4e72be338eb38167c434	Summary of the results of the cell uptake studies of [68Ga]Ga-1–[68Ga]Ga-11 and [125I]I-hEGF on EGFR-positive A431 cells after 1 h of incubation under non-blocking and blocking conditions. Each experiment was performed thrice, each in triplicate.	PMC9963887	pharmaceuticals-16-00273-g005.jpg
0.465051	6788a6aa81654a4881b2a6c999638260	Graphical depiction of the results of the competitive displacements assays of 1–11 as well as the positive control hEGF on EGFR-positive A431 cells using [125I]I-hEGF as the competitor. Each experiment was performed at least thrice, each in triplicate, depicted in different colors.	PMC9963887	pharmaceuticals-16-00273-g006.jpg
0.379915	cc4fb94e425b4d4fbd61c73110b575e6	Schematic depiction of the synthesis strategy of the labeling precursors 1–11 exemplified for 9. Reaction conditions: (a) cleavage of Fmoc-protecting group: piperidine/DMF (1/1, v/v), 2 + 5 min; (b) activation of amino acid: 2.0 equiv. amino acid derivative, 2.0 equiv. DIPEA, 1.9 equiv. HBTU in DMF, 2 min, 15 min conjugation; (c) mildly acidic cleavage of lysine Nε-Mtt protecting group: DCM/TFA (99/1, v/v), 30–45 min; (d) activation of NODA-GA(tBu)3: 2.0 equiv., 2.0 equiv. DIPEA, 1.9 equiv. PyBOP in DMF, 2 min, 30 min conjugation; (e) mildly acidic cleavage of cysteine Mmt protecting group: DCM/TFA (98/2, v/v), 45 min; (f) cyclization by dithiol-formation using 1.05 equiv. NCS in DMF, 15 min; (g) cleavage of peptide from resin and simultaneous deprotection of side chain functional groups: TFA/TIS/H2O (95/2.5/2.5, v/v/v), 3 h.	PMC9963887	pharmaceuticals-16-00273-sch001.jpg
0.422667	89e26ccafe404001a433aa61f540ad43	EphB1 expression is increased in activated HSCs. (A,B) The relative mRNA and protein levels of EphB1 and the typical pro-fibrotic marker proteins in human LX-2 cells stimulated with or without TGF-β1 (5 ng/mL). (C,D) The relative mRNA and protein levels of EphB1 and several other typical pro-fibrotic genes in rat HSC-T6 cells stimulated with or without TGF-β1 (5 ng/mL). Values shown are means ± SEM: * p < 0.05, p < 0.01, * p < 0.001 vs. control.	PMC9964663	ijms-24-03415-g001.jpg
0.479376	78069735d3684e13982ce8d40efc0360	EphB1 is neddylated in activated HSCs. (A) Analysis of EphB1 neddylation in HSCs treated with or without TGF-β1 (5 ng/mL) and MLN4924 (1 μM) for 24 h. (B) HA-immunoblot of Myc-immunoprecipitate from HEK293T cells transfected with Myc-tagged EphB1 and HA-tagged NEDD8 or NEDD8 ΔGG. (C) Effects of MLN4924 on the EphB1 neddylation in HEK293T cells transfected with the indicated constructs. (D) Effects of NEDP1 on the EphB1 neddylation in HEK293T cells transfected with the indicated constructs.	PMC9964663	ijms-24-03415-g002.jpg
0.476619	af4f337e5a3442c59fad08193d4dbd4e	Neddylation stabilizes EphB1 by antagonizing its ubiquitination. (A) Effects of neddylation blockade by MLN4924 (1 μM) on the EphB1 phosphorylation in LX-2 cells. * p < 0.05 vs. Control; ## p < 0.01 vs. TGF-β1 treatment group. (B) Assessment of EphB1 protein stability in LX-2 cells. LX-2 cells were treated with DMSO or MLN4924 (1 μM) for 24 h, and then with CHX (100 μg/mL) for various periods of time as indicated. Cell lysates were then harvested and subjected to immunoblotting with the indicated antibodies. (C) EphB1 protein expression in LX-2 cells treated with MLN4924 (1 μM), MG-132 (10 μM), or their combination. Values shown are means ± SEM. * p < 0.05, p < 0.01, * p < 0.001 vs. DMSO; ### p < 0.001 vs. MLN4924 treatment group. (D) Analysis of EphB1 neddylation and ubiquitination levels in activated LX-2 cells treated with or without MLN4924 (1 μM). (E) Analysis of EphB1 neddylation and ubiquitination levels in activated LX-2 cells treated with or without MG-132 (10 μM). (F) Analysis of EphB1 neddylation and ubiquitination levels in HEK293T cells transfected with flag-tagged EphB1, HA-tagged Ub, or Myc-tagged NEDD8 as indicated.	PMC9964663	ijms-24-03415-g003.jpg
0.37005	825da05de13d4d41954ca40d8488f886	EphB1 promotes the proliferation, migration, and activation of HSCs. (A) Effects of exogenous overexpression of EphB1 on the expression of pro-fibrotic markers in LX-2 cells. (B) Effects of EphB1 overexpression on the cell proliferation of LX-2 cells. (C) Microscopic inspection of LX-2 cells transfected with empty vector or EphB1 expression plasmid after scratching (0 h) and after 24 h of wound healing (40× magnification, scale bar, 200 μm). (D) Effects of EphB1 knockdown on the expression of pro-fibrotic markers in LX-2 cells. (E) Effects of EphB1 knockdown on the cell proliferation of LX-2 cells. (F) Effects of EphB1 knockdown on the migration of LX-2 cells as determined in (C) (40× magnification, scale bar, 200 μm). Values shown are means ± SEM. * p < 0.05, p < 0.01, * p < 0.001 vs. control.	PMC9964663	ijms-24-03415-g004.jpg
0.40817	dc091d775c7c4ddc98d212bcf7fb5c06	EphB1 is neddylated in CCl4-induced liver fibrosis mice. (A) Schema of the mice experimental protocol. Mice were administrated as indicated by the arrows. (B) Representative histopathological images of H&E and Masson’s trichrome staining of mouse liver sections (400× magnification, scale bar, 100 μm). (C) Serum levels of ALT, AST, T-Bil, and hydroxyproline content in mouse livers. (D) The protein expression of EphB1 and the pro-fibrotic marker proteins in the liver tissues of mice treated with Oil (Control group), CCl4 (Model group), CCl4, plus MLN4924 (MLN4924 group). (E) Analysis of EphB1 neddylation in the liver tissues of mice treated with Oil, CCl4, CCl4 plus MLN4924. Values shown are means ± SEM. *** p < 0.001 vs. Control; ## p < 0.01, ### p < 0.001 vs. Model.	PMC9964663	ijms-24-03415-g005.jpg
0.407646	93f5cbbce38442afb33c77ffbeebf919	PRISMA diagram.	PMC9964749	ijerph-20-03628-g001.jpg
0.485374	45af8a46bb5d453283c0ae1f2cda0f73	Count of studies by year of publication.	PMC9964749	ijerph-20-03628-g002.jpg
0.351057	c96e59bffc474f9f84bdd256984f6801	Main peer role by positively associated domain.	PMC9964749	ijerph-20-03628-g003.jpg
0.405547	17556d7b68ee45d5a95717d221116859	Sample of initial images.	PMC9964756	polymers-15-00876-g001.jpg
0.443409	07aea8b167aa4a3e98a7ce74899331bb	Acquired image (a) and output (b) from step 1 processing.	PMC9964756	polymers-15-00876-g002.jpg
0.576146	505495112f6245678180f764af9b405d	Result obtained after the processing in step 2.	PMC9964756	polymers-15-00876-g003.jpg
0.552877	030923f27d3c4aedb729f9d99074bace	Result obtained after processing from step 3.	PMC9964756	polymers-15-00876-g004.jpg
0.526038	a0e85a8020bb49a78f0eef6186059abe	Result obtained after processing from step 4.	PMC9964756	polymers-15-00876-g005.jpg
0.486254	5d779d6b52014a7f97ab88b82177ac20	Final results obtained from post-processing in step 5: (a) SG mask and (b) SG contour (yellow) superimposed on the acquired image.	PMC9964756	polymers-15-00876-g006.jpg
0.487252	ad01a77ab0e94a488e0b9514910541ac	Image extraction of SG and orientation in approximately horizontal position: (a) phase 1 and (b) phase 2.	PMC9964756	polymers-15-00876-g007.jpg
0.431523	3009c439e2534266999603b972ba89df	Obtaining the binary image for the type 1 transducer (step 3).	PMC9964756	polymers-15-00876-g008.jpg
0.387631	68c371ee12a7401884a02f6499e01d42	Obtaining the binary image for the type 2 transducer (step 3).	PMC9964756	polymers-15-00876-g009.jpg
0.380057	cf57f7f8ea1748e5861949cfce3fad0c	Obtaining the binary image for the type 3 transducer (step 3).	PMC9964756	polymers-15-00876-g010.jpg
0.424933	8857196f0325414eb2204880d841946d	Extracting objects from the binary image and overlaying contours over the original image (step 4).	PMC9964756	polymers-15-00876-g011.jpg
0.614309	485b0837ea8b4b0894a62f68553bbad2	Triangular object selection procedure (step 5)—South triangular object.	PMC9964756	polymers-15-00876-g012.jpg
0.625594	115af886d6de4a94817a9d8bc066b7d3	Triangular object selection procedure (step 5)—East triangular object.	PMC9964756	polymers-15-00876-g013.jpg
0.599698	47d9947975f3431fbe859cb2cda0ce61	Triangular object selection procedure (step 5): non-triangular object.	PMC9964756	polymers-15-00876-g014.jpg
0.586462	1975fd9411864e68bbb4d3489d5dc6d3	Triangular object selection procedure (step 5): non-triangular object.	PMC9964756	polymers-15-00876-g015.jpg
0.42612	6ed94756dc7a4e87ac7b7aa0f6e50ba9	The directions parallel and perpendicular to the SG filaments, automatically detected.	PMC9964756	polymers-15-00876-g016.jpg
0.417366	e75e7c1580f240c39061a0d6e89a3ace	The image acquisition environment used in the automatic detection of SG orientation errors (photographing the composite board).	PMC9964756	polymers-15-00876-g017.jpg
0.471501	f4fb29c361b64dae908476e25223cd4c	PAP-CCVH, participatory program for cardiovascular and cerebrovascular health (experimental group); CLP-CCVH, conventional lecture program for cardiovascular and cerebrovascular health (comparative group). Flow chart of participants.	PMC9964897	ijerph-20-03210-g001.jpg
0.43806	56af6b3b22154b8d88ebb199e8d88d86	The 17th-century ciborium studied and its state of conservation. Scale bar equal to 5 cm.	PMC9965309	materials-16-01424-g001.jpg
0.47231	d10e7eaa7dd04319aff3a32daad6314a	Summary diagram of the different steps of the complete experimental work used in this study.	PMC9965309	materials-16-01424-g002.jpg
0.413828	37c2ffd7c85c48ee8fdacf02369424d5	Manual reproduction of column with component measurements (Scale bar equal to 5 cm).	PMC9965309	materials-16-01424-g003.jpg
0.499316	63548c49cbe84122a62d03caf4cdcb89	Steps of three-dimensional modeling of the column: modeling of the volutes (A) and the assembled capital (B) using Rhinoceros software; 3D model of the upper section of the column, front of the capital and whole column using Rhinoceros software (C); transversal section of the column (left) and modeling (right) of structural components using Fusion 360 software (D).	PMC9965309	materials-16-01424-g004.jpg
0.44256	7ad1e5e394244190a452fa4dfb108ded	Prototypes printed with PLA (A) and final model of column in PETG (B). Scale bar equal to 5 cm.	PMC9965309	materials-16-01424-g005.jpg
0.439152	4718a090b81a40ecbce4811df710262b	3D model of column in PETG: grooves and hole for the threaded aluminium bar at half height of the shaft (A), detail of the two parts of the column joined together thanks to the grooves (B), holes for the threaded aluminium bar and cap (C) and assembled column (D). Scale bar equal to 5 cm.	PMC9965309	materials-16-01424-g006.jpg
0.475555	76f34ce4f6cd43fd9d8fa705ef424402	Main phases of column restoration: copy of column (A), modelling the capital with stucco using a scalpel (B), application of gold leaf on bolus (C), copy of column with gouache gilding (D), aluminium bar insertion operation (E), original column with retouching by striping or hatching (F). Scale bar equal to 5 cm.	PMC9965309	materials-16-01424-g007.jpg
0.518035	9ba5ab824a3146e3ba764669512be5ee	(a) Absorption and (b) normalized emission spectra of NH2NBS, EtNBS, and NMe2NBS in dichloromethane solution. (c) The bleaching rates of DPBF by photoinduced 1O2 in MeOH (ΔOD represents the absorption difference of DPBF at 410 nm before and after 635 nm laser irradiation). (d) The oxidation rate of DHR 123 by the photoinduced O2−• radical in the PBS solution (F0 and F represent the fluorescence intensity of DHR123 at 526 nm before and after 635 nm laser irradiation, respectively). The concentration used for each compound was 10 μΜ.	PMC9965410	molecules-28-01714-g001.jpg

0.474289

3c009e8742554ad28ae266b6625861fe

Effect of nitrogen deficiency on gene expression in peanut roots. Statistical analysis of DEGs during nitrogen deficiency treatment for 5 and 10 days. (A) The number of significantly upregulated and downregulated expressed genes; (B) Venn diagrams of DEGs from two root comparisons; (C) heatmap of overlapped DEGs in HNR05 vs. LNR05 and HNR10 vs. LNR10 comparisons.

PMC9960604

plants-12-00732-g004.jpg

0.477903

145ff8c7adf84e208e2c499c54cc33b8

GO annotation terms of DEGs from HNR05 vs. LNR05 and HNR10 vs. LNR10.

PMC9960604

plants-12-00732-g005.jpg

0.423044

4cbcb4f474f246c18453c509cf568550

DEGs participated in nitrate transportation and assimilation. (A) Heatmap of DEGs related to nitrate transportation and assimilation. I: HNR05 vs. LNR05; II: HNR10 vs. LNR10. (B) Nitrate transportation and assimilation process in HNR10 vs. LNR10. For each rectangular shape, red shapes represent upregulated DEGs, while blue shapes represent downregulated DEGs.

PMC9960604

plants-12-00732-g006.jpg

0.38247

e22abf482feb484aa445dd9adf9e0e62

DEGs related to plant hormone signal transduction. (A) Heatmap of DEGs related to plant hormone signal transduction pathways. I: HNR05 vs. LNR05; II: HNR10 vs. LNR10. (B) Plant hormone signal transduction process in HNR10 vs. LNR10. For each rectangular shape, red shapes represent upregulated DEGs, while blue shapes represent downregulated DEGs.

PMC9960604

plants-12-00732-g007.jpg

0.490915

a689f06e2ec04c9fb87191ccd3018ba6

DEGs participated in lignin biosynthetic pathway. (A) Heatmap of DGs related to lignin biosynthetic pathway. I: HNR05 vs. LNR05; II: HNR10 vs. LNR10; (B) lignin biosynthetic pathway in HNR10 vs. LNR10. For each rectangular shape, red shapes represent upregulated DEGs, while blue shapes represent downregulated DEGs.

PMC9960604

plants-12-00732-g008.jpg

0.447325

66db863855994229966d2e571e5c5565

Predicted protein–protein interaction networks of all DEPs in roots under 10 days of nitrogen deficiency. Red hexagons represent upregulated DEPs; green hexagons represent downregulated DEPs. The full names of all the abbreviations above are shown in Table S12.

PMC9960604

plants-12-00732-g009.jpg

0.405422

0e3c750500a34b08856b25fcb7445323

A proposed model for the mechanism underlying the inhibition of peanut roots by nitrogen deficiency. Notes: Red arrows represent upregulated and green arrows represent downregulated genes. ABA: abscisic acid; CAD: Cinnamyl alcohol dehydrogenase; 4CL: 4-coumarate--CoA ligase; NRT1.1: nitrate transporter 1.1; NRT1.2: nitrate transporter1.2; PLA: phenylalanine ammonia-lyase; POD: peroxidase; PP2C: phosphatase 2C.

PMC9960604

plants-12-00732-g010.jpg

0.448083

89a7e2aa28b7420e8b1b9c9d3759f78c

Pipeline of performed data consolidation.

PMC9961470

ijms-24-04011-g001.jpg

0.438427

dde40de7185d4b65b7d3eafff74d6c44

Multiple sequence alignment of 9930, Gy14, and B10v3 genomes of data from CuGenDBv2 database. The red vertical lines indicate the boundaries of the individual chromosomes, which have been signed according to the numbering in each genome. Colored boxes represent common elements between the compared genomes, and grey areas are unique to the depicted genome.

PMC9961470

ijms-24-04011-g002.jpg

0.450771

6dfedecb5cee4b1b9eeda55e6d69be29

Comparison of arrangement tools: RagTag, Mauve Contig Mover, Multi-CSAR. As a reference 9930 genome was used. Colored boxes represent common elements between the compared genomes, and grey areas are unique to the depicted genome. The red vertical lines indicate the boundaries of the individual chromosomes.

PMC9961470

ijms-24-04011-g003.jpg

0.478813

580b14de0ab848ffbe582f54c712a1c8

RagTag result of B10v3 genome rearrangement and assigned to chromosome with use of filtered 9930 reference genome visualized in Mauve software. The red vertical lines indicate the boundaries of the individual chromosomes.

PMC9961470

ijms-24-04011-g004.jpg

0.477097

dc877a92028a4956a326e688bd1b1f3f

RagTag result of B10v3 rearrangement using filtered Gy14 reference and assigned to chromosome visualized in Mauve software. The red vertical lines indicate the boundaries of the individual chromosomes.

PMC9961470

ijms-24-04011-g005.jpg

0.455666

452bc4226a3141298ec5f49c1573b064

Comparative and corresponding B10 numbering (upper) to 9930/Gy14 numbering (down). Chromosome number (Ch) according to Han et al. [21] and Yang et al. [3] work. Karyotype of B10 showed FISH signals (left) and sequential DAPI and CMA staining (right). Karyotype of 9930 and Gy14 showed only FISH signals. The arrows indicate the chromosome equivalent of the B10v3 version (upper) vs. 9930 and Gy14 (down).

PMC9961470

ijms-24-04011-g006.jpg

0.439887

3c2ba2d0f4ec43b1a28183a8104e79ac

Probe localization on three cucumber line chromosomes: B10, 859, and CSH55. (A) DAPI staining, (B) CMA staining, (C) Type IV (red) and 45S rDNA (green), and (D) Type III (orange) and Type IV (red). Scale bar = 5 μm.

PMC9961470

ijms-24-04011-g007.jpg

0.417958

2fd9cb538c0949738e661254fbc6527d

Exosome extraction from human plasma and lysis to release target molecules. Colorimetric responses of PT upon the addition of PNA and various concentrations of the mir21-spiked exosomes.

PMC9962048

molecules-28-01909-g001.jpg

0.424047

f1371e8e66694251b419aba6df62922c

Electron microscopy images of exosome sample (a) before lysis (as indicated by the white arrow that shows an exosome) and (b) after lysis (as indicated in the white box whereby the vesicles have been ruptured).

PMC9962048

molecules-28-01909-g002.jpg

0.428138

0749b85e558c40f58ef5a3bd3aa29ee2

Size distribution spectrum of (a) exosome sample before lysis, (b) exosome sample after lysis, and (c) 0.1% Triton X-100.

PMC9962048

molecules-28-01909-g003.jpg

0.454113

c339665d1c404c85b6943108cabc13e6

Colorimetric responses (digital images) of varying amounts (1×, 10×, 0×) of (a) exosomes with PT in MilliQ in Vials A–C, (b) exosomes with PT in PBS in Vials D–F, and (c) exosomes with PT-T20 in PBS in Vials G–I, and their corresponding fluorescence spectra (d–f), respectively.

PMC9962048

molecules-28-01909-g004.jpg

0.490521

38bd15a3a3dc4f73ab89e79860a24c55

Melting curve of mir21 expression (20 cycles).

PMC9962048

molecules-28-01909-g005.jpg

0.397477

8741aeaa24b84aaeb7c35371ee2d0c35

mir21 assay (a–d): (a) digital images of vials containing (A) PT-T20-PNA1-1 μM mir21 (control), and (B–F) PT-T20 with 4 μM, 2 μM, 1 μM, 500 nM and 250 nM mir21 and, (b) corresponding fluorescence spectra, (c) ΔE values calculated with respect to vial A and (d) linear plot of mir21 concentration versus normalized fluorescence intensity.

PMC9962048

molecules-28-01909-g006.jpg

0.448175

814568d1d0924a4eae0efcc497249f2d

Association of fetuin-A at T0 (a) and at T24 (b).

PMC9962253

ijms-24-03203-g001.jpg

0.487086

cf20fdb0962641f09a3be99af8446815

Scatterplot: Association of Fetuin-A at T0 and of mNY at T0.

PMC9962253

ijms-24-03203-g002.jpg

0.461634

d7af42d2e8a04531a895b8ef0b40bacf

Scatterplot: Association of Fetuin-A at T24 and of mNY at T24.

PMC9962253

ijms-24-03203-g003.jpg

0.512912

273df3fd17b44089a888f76cb2dfc5e6

Scatterplot: Association of Fetuin-A at T0 and of mNY at T24.

PMC9962253

ijms-24-03203-g004.jpg

0.39046

6495431fc81944d6876d23e8a3d33433

Correlations between serum 25(OH)D concentration and (A) BMI, (B) muscle mass, (C) fat mass, and (D) PTH levels in LDD patients. r: Spearman’s coefficient, statistically significant at p < 0.05.

PMC9962334

ijms-24-03152-g001.jpg

0.420713

3224b135c7344dccb2ce379bb30196e5

Evaluation of gait speed physical performance: (A) Comparison of gait speed between patients with vitamin D sufficiency and insufficiency. p-value was calculated with the Mann–Whitney U test. (B) Comparison of gait speed between patients, classified by ODI score. p-value was evaluated by Friedman’s two-way analysis of variance (ANOVA) test. (C) Correlation between serum 25(OH)D and gait speed.

PMC9962334

ijms-24-03152-g002.jpg

0.413102

ce1e41b9f5f946a28732f49222663053

Determination of chair stand test: (A) Comparison of chair stand test between patients with vitamin D sufficiency and insufficiency. p-value was calculated with the Mann–Whitney U test. (B) Comparison of chair stand test between patients, classified by ODI score. p-value was examined using Friedman’s two-way ANOVA test. (C) Correlation between serum 25(OH)D and the time in chair stand test.

PMC9962334

ijms-24-03152-g003.jpg

0.408672

ce52f7ad877844aca18bdf546e0cce3c

Determination of TUG test: (A) Comparison of TUG test between patients with vitamin D sufficiency and insufficiency. p-value was analyzed using the Mann–Whitney U test. (B) Comparison of TUG test between patients, classified by ODI score. p-value was calculated with Friedman’s two-way ANOVA test. (C) Correlation between serum 25(OH)D and the time in the TUG test.

PMC9962334

ijms-24-03152-g004.jpg

0.463789

766cbd87c05b4907ab3d85965cdff0ee

Schematic illustration of nasal end-tidal carbon dioxide (PetCO2) and transcutaneous carbon dioxide (PtcCO2) monitoring. An end-tidal sample line was inserted into the nasopharyngeal airway to monitor PetCO2. A transcutaneous monitoring probe was placed on the forearm ipsilateral to the non-operated lung to monitor PtcCO2.

PMC9962657

jcm-12-01706-g001.jpg

0.500659

4716714ab8ff430082eef5387a0a4479

The receiver operating characteristic (ROC) curves comparing the predictive power of PtcCO2 and PetCO2 monitoring for hypercapnia (PaCO2 > 60 mmHg). PetCO2, end-tidal carbon dioxide partial pressure; PtcCO2, transcutaneous carbon dioxide partial pressure; PaCO2, partial pressure of arterial carbon dioxide.

PMC9962657

jcm-12-01706-g002.jpg

0.461035

79563d81fedb4ab7bc719fc1002000e6

Correlation of PtcCO2 and PetCO2 with PaCO2 during (a) two-lung ventilation and (b) one-lung ventilation. PetCO2, end-tidal carbon dioxide partial pressure; PtcCO2, transcutaneous carbon dioxide partial pressure; PaCO2, partial pressure of arterial carbon dioxide.

PMC9962657

jcm-12-01706-g003.jpg

0.512625

9566a386b3aa4f4c9ee7304dba4c40a5

Bland–Altman plots comparing the agreement between (a) PaCO2 and PtcCO2 and (b) PaCO2 and PetCO2 during two-lung ventilation. PetCO2, end-tidal carbon dioxide partial pressure; PtcCO2, transcutaneous carbon dioxide partial pressure; PaCO2, partial pressure of arterial carbon dioxide; SD, standard deviation.

PMC9962657

jcm-12-01706-g004a.jpg

0.443027

2534b55caaea454881415ba1281c7da8

Bland–Altman plots comparing the agreement between (a) PaCO2 and PtcCO2 and (b) PaCO2 and PetCO2 during one-lung ventilation. PetCO2, end-tidal carbon dioxide partial pressure; PtcCO2, transcutaneous carbon dioxide partial pressure; PaCO2, partial pressure of arterial carbon dioxide; SD, standard deviation.

PMC9962657

jcm-12-01706-g005.jpg

0.486843

2f7c12ba7e4e479a8fc4ff0c919e92b3

Structures of isolated compounds 1−20 from V. rotundifolia.

PMC9962727

metabolites-13-00249-g001.jpg

0.455182

ae6be27728e94cf2bc92ee56f80c2477

CD spectrum (A) and key HMBC, COSY, 1D NOE, and NOESY (B) correlations of compound 1.

PMC9962727

metabolites-13-00249-g002.jpg

0.368086

b73cc5e55bfb47f4936616184f671990

Modified Mosher’s method.

PMC9962727

metabolites-13-00249-g003.jpg

0.393986

b3f0659f4cd848099f30dd3742b37b4f

Antioxidant effect of compounds (1−20). The DPPH assay was performed in triplicate. The data are represented as mean ± SD. * p < 0.05, compared to control (CON).

PMC9962727

metabolites-13-00249-g004.jpg

0.419122

914090283e154fc3acb92d5e2ac62f96

Cytotoxic effects (A) and NO production inhibitory effects (B) of isolated compounds (1−20 at 10 and 100 μM) in LPS-stimulated RAW264.7 cells. RAW264.7 cells were treated with compounds 1−20 (10 and 100 µM) for 1 h and stimulated with LPS (1 μg/mL) for 16 h. (A) The viability of cells was determined using an MTT assay. (B) The level of NO production in serum-free culture medium was measured. Both experiments were performed in triplicate. The data are represented as mean ± SD. *p < 0.05, **p < 0.01, compared to the LPS-treated group.

PMC9962727

metabolites-13-00249-g005.jpg

0.412946

a0eaaa1e83f340f4b0ea4d1ea7fefb13

Cytotoxic effects (A) and IL-8 production inhibitory effects (B) of compounds in LPS-induced HT-29 cells. HT-29 cells were treated with compounds 1−20 (10 and 100 µM) for 2 h and stimulated with LPS (100 ng/mL) for 12 h. (A) The viability of cells was determined using an MTT assay. (B) The level of IL-8 in the culture media was measured with an ELISA kit. The values are expressed as mean ± standard deviation of three individual experiments. * p < 0.05, ** p < 0.01, compared to the LPS-treated group.

PMC9962727

metabolites-13-00249-g006.jpg

0.451351

665f9a9dc8044c45a38146d87eac8f28

Binding poses and interactions between binding sites of the IL-8 receptor with respect to ligands (compounds 8 (A), 9 (B), 13 (C), 14 (D), and 19 (E)).

PMC9962727

metabolites-13-00249-g007.jpg

0.391598

3f05b587fe0046c793a28e1c457689a4

Map of Tehran, Iran, showing the spatial distribution of COVID-19 mortality 2019–2021; EBS = empirical Bayes smoothed mortality rates per 100,000 population at the neighbourhood level. Numbers indicate the administrative district division of the city. Each district includes some neighbourhoods.

PMC9962969

tropicalmed-08-00085-g001.jpg

0.404886

ad4ea7cf06b4414993dbd560a1e2622a

Spatial distributions for selected explanatory variables in Tehran, Iran. Dark blue shades show low ranges and dark red shades show high range values for each variable (numbers as given in Table 1).

PMC9962969

tropicalmed-08-00085-g002.jpg

0.463268

2d0a6c04226d4d2e86cae4c97b8ea1e5

Methodology flowchart of the study of COVID-19 mortality in Tehran.

PMC9962969

tropicalmed-08-00085-g003.jpg

0.423131

dba4704fb8ab4a759fdc44acf34ae3e1

(a): Monthly distribution chart of the mortality rates (per 100,000 population) by number and sex; (b): percentage of COVID-19 related deaths by number, sex, and age group.

PMC9962969

tropicalmed-08-00085-g004.jpg

0.419958

db74a7bd49fe4f77bb208fa994522e0f

Purely temporal significant clusters of COVID-19 deaths during 2019 to 2021 in the study area.

PMC9962969

tropicalmed-08-00085-g005.jpg

0.45766

ce795ce77c124297871fac99dbd7de07

Detected purely spatial clusters of COVID-19 deaths in Tehran, Iran.

PMC9962969

tropicalmed-08-00085-g006.jpg

0.458869

57c3c9e60afa40fda11529ac678b0447

Detected space-time clusters of COVID-19 deaths in Tehran, Iran.

PMC9962969

tropicalmed-08-00085-g007.jpg

0.446822

899824fb7d564166ab5fb45855214e98

Spatial distribution of local R2 values for GWR and MGWR models. (A): Map of the GWR local R2 values, (B): Map of the MGWR local R2 values, (C): Histogram chart depicting the distribution of GWR R2 values; and (D): Histogram chart depicting the distribution of MGWR R2 values in the study area.

PMC9962969

tropicalmed-08-00085-g008.jpg

0.409697

5f7b5f7518f84806a6a00ee9b1f741e4

Surface map of local estimates pseudo t-values of MGWR model results for Tehran’s COVID-19 mortality rate dataset. Dark blue shades show areas with high t-values. All maps were generated in ArcGIS Pro 3.0.2 (ESRI, Redlands, CA, USA, 2022).

PMC9962969

tropicalmed-08-00085-g009.jpg

0.454927

57c6ae9247f0439886286f005e8bb93d

Spatial distribution bivariate map of local estimates (Beta) and covariates original values of MGWR model results for Tehran’s COVID-19 mortality rates. All the maps were generated in ArcGIS Pro 3.0.2 (ESRI, Redlands, CA, USA, 2022).

PMC9962969

tropicalmed-08-00085-g010.jpg

0.504633

d4fdfc56a29a4ebcb8c05dfe8a4d0b95

Co-pyrolysis of C4 hydrocarbons and hexane: conversion of C4 hydrocarbons (●1-butene; ● 2-butene; ● isobutane; ● butane; and ● isobutene) in dependence on their mole fraction in the binary mixture. Points represent experimental data and lines were obtained from regression analysis.

PMC9962995

materials-16-01418-g001.jpg

0.414386

0e9f89ac523546d2b7bb25cbf24775ae

Co-pyrolysis of C4 hydrocarbons and cyclohexane: conversion of C4 hydrocarbons (●1-butene; ● 2-butene; ● isobutane; ● butane; and ● isobutene) in dependence on their mole fraction in the binary mixture. Points represent experimental data and lines were obtained from regression analysis.

PMC9962995

materials-16-01418-g002.jpg

0.473626

cfcdfe46bdb04e6dab260e4fe71853f7

Co-pyrolysis of C4 hydrocarbons and 3-methylpentane: conversion of C4 hydrocarbons (○ 2-butene and ● isobutene) in dependence on their mole fraction in the binary mixture. Points represent experimental data; solid line was obtained from regression analysis and dashed line is a simulation.

PMC9962995

materials-16-01418-g003.jpg

0.465837

6b0ee8c6f2a74f1f9909654a406662eb

Co-pyrolysis of C4 hydrocarbons and heptane: conversion of C4 hydrocarbons (○ 2-butene and ● isobutene) in dependence on their mole fraction in the binary mixture. Points represent experimental data; solid line was obtained from regression analysis and dashed line is a simulation.

PMC9962995

materials-16-01418-g004.jpg

0.435774

c3c469bb11814ee9ba90925561e80442

3D visualization of snack pellets and crisps expanded by selected methods: P—unexpanded pellets, F—crisps expanded by frying in deep oil, M—crisps expanded by microwaving, A—crisps expanded by hot-air toasting, 0–30 amount of fresh carrot pulp (%).

PMC9963299

materials-16-01541-g001.jpg

0.398699

043d99bc4fa944a7ba85535528ca2c16

Cross-section of snack pellets and crisps expanded by selected methods: P—unexpanded pellets, F—crisps expanded by frying in deep oil, M—crisps expanded by microwaving, A—crisps expanded by hot-air toasting, 0–30 amount of fresh carrot pulp (%).

PMC9963299

materials-16-01541-g002.jpg

0.440455

62cce49ed51f4e4f9a83740536f9497d

Pore size and wall thickness distribution in snack pellets and crisps expanded by selected methods: P—unexpanded pellets, F—crisps expanded by frying in deep oil, M—crisps expanded by microwave, A—crisps expanded by hot-air toasting, 0–30 amount of fresh carrot pulp (%).

PMC9963299

materials-16-01541-g003.jpg

0.391394

13a0ff4b13944d4a90e8832014346d1c

PCA analysis of snack pellets and expanded crisps features.

PMC9963299

materials-16-01541-g004.jpg

0.465369

8a0a187ac08140a8b051625a5c617c57

The crisps objects in space of first two major components by PCA (principal component analysis) (a), and the dendrogram obtained by HCA (hierarchical cluster analysis) application (b). F—crisps expanded by frying in deep oil, M—crisps expanded by microwave, A—crisps expanded by hot-air toasting, 0–30 amount of fresh carrot pulp (%); different colors of circles mean similar homogenous groups.

PMC9963299

materials-16-01541-g005.jpg

0.473352

f2e4eb197fa142f68f17e71932398e75

Structures of the peptide leads GE11, D4, CPP, P1, P2, EGBP, Pep11, QRH and hEGF of which chelator-modified and radiolabeled analogs were developed of and tested for their potential to be applied as agents for EGFR-specific tumor targeting. In the structure of hEGF, the three loops of the peptide are colored in red (A loop), blue (B loop) and green (C loop), while the part of the peptide belonging to both the A and the B loop is depicted in purple.

PMC9963887

pharmaceuticals-16-00273-g001.jpg

0.404985

2e43f7c170e4425d9e659fd9637a7aac

Structures of the N-terminally PEG5-NODA-GA-modified labeling precursors based on the peptides GE11 (1), D4 (2), P1 (3) and P2 (4).

PMC9963887

pharmaceuticals-16-00273-g002.jpg

0.451313

877f96dd84474337b3db3e63b00f1395

Structures of the C-terminally PEG5-NODA-GA-modified labeling precursors based on the peptides QRH (5), CPP (6), EGBP (7), the three loops of the hEGF (8–10) and Pep11 (11).

PMC9963887

pharmaceuticals-16-00273-g003.jpg

0.473546

d09a9ba47549465ebe67df5008e9e2c7

Analytical radio-HPLC chromatograms of [68Ga]Ga-1–[68Ga]Ga-11 as obtained directly after radiolabeling of 1–11 with 68Ga3+.

PMC9963887

pharmaceuticals-16-00273-g004.jpg

0.48269

a19601df0fad4e72be338eb38167c434

Summary of the results of the cell uptake studies of [68Ga]Ga-1–[68Ga]Ga-11 and [125I]I-hEGF on EGFR-positive A431 cells after 1 h of incubation under non-blocking and blocking conditions. Each experiment was performed thrice, each in triplicate.

PMC9963887

pharmaceuticals-16-00273-g005.jpg

0.465051

6788a6aa81654a4881b2a6c999638260

Graphical depiction of the results of the competitive displacements assays of 1–11 as well as the positive control hEGF on EGFR-positive A431 cells using [125I]I-hEGF as the competitor. Each experiment was performed at least thrice, each in triplicate, depicted in different colors.

PMC9963887

pharmaceuticals-16-00273-g006.jpg

0.379915

cc4fb94e425b4d4fbd61c73110b575e6

Schematic depiction of the synthesis strategy of the labeling precursors 1–11 exemplified for 9. Reaction conditions: (a) cleavage of Fmoc-protecting group: piperidine/DMF (1/1, v/v), 2 + 5 min; (b) activation of amino acid: 2.0 equiv. amino acid derivative, 2.0 equiv. DIPEA, 1.9 equiv. HBTU in DMF, 2 min, 15 min conjugation; (c) mildly acidic cleavage of lysine Nε-Mtt protecting group: DCM/TFA (99/1, v/v), 30–45 min; (d) activation of NODA-GA(tBu)3: 2.0 equiv., 2.0 equiv. DIPEA, 1.9 equiv. PyBOP in DMF, 2 min, 30 min conjugation; (e) mildly acidic cleavage of cysteine Mmt protecting group: DCM/TFA (98/2, v/v), 45 min; (f) cyclization by dithiol-formation using 1.05 equiv. NCS in DMF, 15 min; (g) cleavage of peptide from resin and simultaneous deprotection of side chain functional groups: TFA/TIS/H2O (95/2.5/2.5, v/v/v), 3 h.

PMC9963887

pharmaceuticals-16-00273-sch001.jpg

0.422667

89e26ccafe404001a433aa61f540ad43

EphB1 expression is increased in activated HSCs. (A,B) The relative mRNA and protein levels of EphB1 and the typical pro-fibrotic marker proteins in human LX-2 cells stimulated with or without TGF-β1 (5 ng/mL). (C,D) The relative mRNA and protein levels of EphB1 and several other typical pro-fibrotic genes in rat HSC-T6 cells stimulated with or without TGF-β1 (5 ng/mL). Values shown are means ± SEM: * p < 0.05, ** p < 0.01, *** p < 0.001 vs. control.

PMC9964663

ijms-24-03415-g001.jpg

0.479376

78069735d3684e13982ce8d40efc0360

EphB1 is neddylated in activated HSCs. (A) Analysis of EphB1 neddylation in HSCs treated with or without TGF-β1 (5 ng/mL) and MLN4924 (1 μM) for 24 h. (B) HA-immunoblot of Myc-immunoprecipitate from HEK293T cells transfected with Myc-tagged EphB1 and HA-tagged NEDD8 or NEDD8 ΔGG. (C) Effects of MLN4924 on the EphB1 neddylation in HEK293T cells transfected with the indicated constructs. (D) Effects of NEDP1 on the EphB1 neddylation in HEK293T cells transfected with the indicated constructs.

PMC9964663

ijms-24-03415-g002.jpg

0.476619

af4f337e5a3442c59fad08193d4dbd4e

Neddylation stabilizes EphB1 by antagonizing its ubiquitination. (A) Effects of neddylation blockade by MLN4924 (1 μM) on the EphB1 phosphorylation in LX-2 cells. * p < 0.05 vs. Control; ## p < 0.01 vs. TGF-β1 treatment group. (B) Assessment of EphB1 protein stability in LX-2 cells. LX-2 cells were treated with DMSO or MLN4924 (1 μM) for 24 h, and then with CHX (100 μg/mL) for various periods of time as indicated. Cell lysates were then harvested and subjected to immunoblotting with the indicated antibodies. (C) EphB1 protein expression in LX-2 cells treated with MLN4924 (1 μM), MG-132 (10 μM), or their combination. Values shown are means ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. DMSO; ### p < 0.001 vs. MLN4924 treatment group. (D) Analysis of EphB1 neddylation and ubiquitination levels in activated LX-2 cells treated with or without MLN4924 (1 μM). (E) Analysis of EphB1 neddylation and ubiquitination levels in activated LX-2 cells treated with or without MG-132 (10 μM). (F) Analysis of EphB1 neddylation and ubiquitination levels in HEK293T cells transfected with flag-tagged EphB1, HA-tagged Ub, or Myc-tagged NEDD8 as indicated.

PMC9964663

ijms-24-03415-g003.jpg

0.37005

825da05de13d4d41954ca40d8488f886

EphB1 promotes the proliferation, migration, and activation of HSCs. (A) Effects of exogenous overexpression of EphB1 on the expression of pro-fibrotic markers in LX-2 cells. (B) Effects of EphB1 overexpression on the cell proliferation of LX-2 cells. (C) Microscopic inspection of LX-2 cells transfected with empty vector or EphB1 expression plasmid after scratching (0 h) and after 24 h of wound healing (40× magnification, scale bar, 200 μm). (D) Effects of EphB1 knockdown on the expression of pro-fibrotic markers in LX-2 cells. (E) Effects of EphB1 knockdown on the cell proliferation of LX-2 cells. (F) Effects of EphB1 knockdown on the migration of LX-2 cells as determined in (C) (40× magnification, scale bar, 200 μm). Values shown are means ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. control.

PMC9964663

ijms-24-03415-g004.jpg

0.40817

dc091d775c7c4ddc98d212bcf7fb5c06

EphB1 is neddylated in CCl4-induced liver fibrosis mice. (A) Schema of the mice experimental protocol. Mice were administrated as indicated by the arrows. (B) Representative histopathological images of H&E and Masson’s trichrome staining of mouse liver sections (400× magnification, scale bar, 100 μm). (C) Serum levels of ALT, AST, T-Bil, and hydroxyproline content in mouse livers. (D) The protein expression of EphB1 and the pro-fibrotic marker proteins in the liver tissues of mice treated with Oil (Control group), CCl4 (Model group), CCl4, plus MLN4924 (MLN4924 group). (E) Analysis of EphB1 neddylation in the liver tissues of mice treated with Oil, CCl4, CCl4 plus MLN4924. Values shown are means ± SEM. *** p < 0.001 vs. Control; ## p < 0.01, ### p < 0.001 vs. Model.

PMC9964663

ijms-24-03415-g005.jpg

0.407646

93f5cbbce38442afb33c77ffbeebf919

PRISMA diagram.

PMC9964749

ijerph-20-03628-g001.jpg

0.485374

45af8a46bb5d453283c0ae1f2cda0f73

Count of studies by year of publication.

PMC9964749

ijerph-20-03628-g002.jpg

0.351057

c96e59bffc474f9f84bdd256984f6801

Main peer role by positively associated domain.

PMC9964749

ijerph-20-03628-g003.jpg

0.405547

17556d7b68ee45d5a95717d221116859

Sample of initial images.

PMC9964756

polymers-15-00876-g001.jpg

0.443409

07aea8b167aa4a3e98a7ce74899331bb

Acquired image (a) and output (b) from step 1 processing.

PMC9964756

polymers-15-00876-g002.jpg

0.576146

505495112f6245678180f764af9b405d

Result obtained after the processing in step 2.

PMC9964756

polymers-15-00876-g003.jpg

0.552877

030923f27d3c4aedb729f9d99074bace

Result obtained after processing from step 3.

PMC9964756

polymers-15-00876-g004.jpg

0.526038

a0e85a8020bb49a78f0eef6186059abe

Result obtained after processing from step 4.

PMC9964756

polymers-15-00876-g005.jpg

0.486254

5d779d6b52014a7f97ab88b82177ac20

Final results obtained from post-processing in step 5: (a) SG mask and (b) SG contour (yellow) superimposed on the acquired image.

PMC9964756

polymers-15-00876-g006.jpg

0.487252

ad01a77ab0e94a488e0b9514910541ac

Image extraction of SG and orientation in approximately horizontal position: (a) phase 1 and (b) phase 2.

PMC9964756

polymers-15-00876-g007.jpg

0.431523

3009c439e2534266999603b972ba89df

Obtaining the binary image for the type 1 transducer (step 3).

PMC9964756

polymers-15-00876-g008.jpg

0.387631

68c371ee12a7401884a02f6499e01d42

Obtaining the binary image for the type 2 transducer (step 3).

PMC9964756

polymers-15-00876-g009.jpg

0.380057

cf57f7f8ea1748e5861949cfce3fad0c

Obtaining the binary image for the type 3 transducer (step 3).

PMC9964756

polymers-15-00876-g010.jpg

0.424933

8857196f0325414eb2204880d841946d

Extracting objects from the binary image and overlaying contours over the original image (step 4).

PMC9964756

polymers-15-00876-g011.jpg

0.614309

485b0837ea8b4b0894a62f68553bbad2

Triangular object selection procedure (step 5)—South triangular object.

PMC9964756

polymers-15-00876-g012.jpg

0.625594

115af886d6de4a94817a9d8bc066b7d3

Triangular object selection procedure (step 5)—East triangular object.

PMC9964756

polymers-15-00876-g013.jpg

0.599698

47d9947975f3431fbe859cb2cda0ce61

Triangular object selection procedure (step 5): non-triangular object.

PMC9964756

polymers-15-00876-g014.jpg

0.586462

1975fd9411864e68bbb4d3489d5dc6d3

Triangular object selection procedure (step 5): non-triangular object.

PMC9964756

polymers-15-00876-g015.jpg

0.42612

6ed94756dc7a4e87ac7b7aa0f6e50ba9

The directions parallel and perpendicular to the SG filaments, automatically detected.

PMC9964756

polymers-15-00876-g016.jpg

0.417366

e75e7c1580f240c39061a0d6e89a3ace

The image acquisition environment used in the automatic detection of SG orientation errors (photographing the composite board).

PMC9964756

polymers-15-00876-g017.jpg

0.471501

f4fb29c361b64dae908476e25223cd4c

PAP-CCVH, participatory program for cardiovascular and cerebrovascular health (experimental group); CLP-CCVH, conventional lecture program for cardiovascular and cerebrovascular health (comparative group). Flow chart of participants.

PMC9964897

ijerph-20-03210-g001.jpg

0.43806

56af6b3b22154b8d88ebb199e8d88d86

The 17th-century ciborium studied and its state of conservation. Scale bar equal to 5 cm.

PMC9965309

materials-16-01424-g001.jpg

0.47231

d10e7eaa7dd04319aff3a32daad6314a

Summary diagram of the different steps of the complete experimental work used in this study.

PMC9965309

materials-16-01424-g002.jpg

0.413828

37c2ffd7c85c48ee8fdacf02369424d5

Manual reproduction of column with component measurements (Scale bar equal to 5 cm).

PMC9965309

materials-16-01424-g003.jpg

0.499316

63548c49cbe84122a62d03caf4cdcb89

Steps of three-dimensional modeling of the column: modeling of the volutes (A) and the assembled capital (B) using Rhinoceros software; 3D model of the upper section of the column, front of the capital and whole column using Rhinoceros software (C); transversal section of the column (left) and modeling (right) of structural components using Fusion 360 software (D).

PMC9965309

materials-16-01424-g004.jpg

0.44256

7ad1e5e394244190a452fa4dfb108ded

Prototypes printed with PLA (A) and final model of column in PETG (B). Scale bar equal to 5 cm.

PMC9965309

materials-16-01424-g005.jpg

0.439152

4718a090b81a40ecbce4811df710262b

3D model of column in PETG: grooves and hole for the threaded aluminium bar at half height of the shaft (A), detail of the two parts of the column joined together thanks to the grooves (B), holes for the threaded aluminium bar and cap (C) and assembled column (D). Scale bar equal to 5 cm.

PMC9965309

materials-16-01424-g006.jpg

0.475555

76f34ce4f6cd43fd9d8fa705ef424402

Main phases of column restoration: copy of column (A), modelling the capital with stucco using a scalpel (B), application of gold leaf on bolus (C), copy of column with gouache gilding (D), aluminium bar insertion operation (E), original column with retouching by striping or hatching (F). Scale bar equal to 5 cm.

PMC9965309

materials-16-01424-g007.jpg

0.518035

9ba5ab824a3146e3ba764669512be5ee

(a) Absorption and (b) normalized emission spectra of NH2NBS, EtNBS, and NMe2NBS in dichloromethane solution. (c) The bleaching rates of DPBF by photoinduced 1O2 in MeOH (ΔOD represents the absorption difference of DPBF at 410 nm before and after 635 nm laser irradiation). (d) The oxidation rate of DHR 123 by the photoinduced O2−• radical in the PBS solution (F0 and F represent the fluorescence intensity of DHR123 at 526 nm before and after 635 nm laser irradiation, respectively). The concentration used for each compound was 10 μΜ.

PMC9965410

molecules-28-01714-g001.jpg