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As altered pubertal development and ovarian morphology were found in 2 of 18 girls , monitoring of puberty and ovarian function during GH therapy in SGA girls is prudent .

Altogether , the findings are reassuring .

However , long-term effects of GH treatment on adult reproductive function remain unknown .

EudraCT 2005-001507-19 .

To test the hypothesis that a brief , clinic-based , single-session programme will reduce the rate of 10 selected condom use errors in a clinical sample of young black men ( YBM ) ages 15 through 23 years .

Data were collected in clinics treating patients with sexually transmitted infections ( STI ) in three southern US cities .

Males 15-23years of age who identified as black/African-American , and reported recent ( past 2months ) condom use were eligible .

Only those also reporting condom use in the 2months prior to a 6-month follow-up assessment ( n = 311 ) were included in this secondary analysis of data from a randomised , controlled trial .

Difference scores were used to capture a GroupTime effect .

YBM reported 2232 condom use events in the 2months preceding study enrolment and 2042 in the 2months preceding the follow-up assessment .

Mean baseline error rates were 1.32 and 1.13 for young men randomised to the intervention and control conditions , respectively .

Follow-up rates were 1.11 and 3.59 for young men randomised to the intervention and control conditions , respectively .

Controlled findings yielded a significant effect for the influence of group assignment on the difference score ( baseline to follow-up ) in the condom use error rate ( = 0.13 ; p = 0.02 ) .

A brief , clinic-based counselling programme produced modest reductions in condom use errors among YBM attending STI clinics in the southern USA Intensified clinic-based intervention that helps YBM improve the quality of their condom use behaviours is warranted .

NCT00849823 .

To provide evidence for Chinese medical treatment of children with EB virus infection by exploring its clinical efficacy from multiple angles .

Totally 81 children patients were randomly assigned to the treatment group ( 46 cases ) and the control group ( 35 cases ) .

Patients in the treatment group took Chinese medical decoction , while those in the control received intravenous dripping of Ganciclovir and oral administration of pidotimod .

The treatment period for the two groups was 2 weeks .

Patients were followed-up till the 12th week .

Clinical symptoms such as fever , lymphadenopathy and hepatosplenomegaly , as well as lab indices such as abnormal lymphocyte percentage , EB virus antibody , virus DNA load , T cell subsets , immunoglobulin , and so on were observed before and after treatment , at week 4 and 12 of follow-ups .

( 1 ) The total effective rate at week 2 was 95.6 % in the treatment group , higher than that of the control group ( 94.3 % ) , but there was no statistical difference between the two groups .

( 2 ) The time for defervescence , duration of pharyngeal hyperemia , duration of swollen tonsils was shorter in the treatment group than in the control group ( P < 0.05 ) .

The subsidence of lymphadenopathy , hepatomegaly , and abnormal lymphocytes was better in the treatment group than in the control group ( P < 0.05 ) .

( 3 ) The positive cases of peripheral blood hetero-lymphocyte was significantly reduced after treatment , at week 4 and 12 of follow-ups both in the treatment group and the control group ( P < 0.01 ) .

The expression of IgA and IgM decreased after treatment in the two groups when compared with before treatment in the same group ( P < 0.05 , P < 0.01 ) .

IgG in the treatment group also obviously decreased after treatment , at week 4 and 12 of follow-ups ( P < 0.05 , P < 0.01 ) , while it decreased only after treatment in the control group ( P < 0.05 ) .

Activities of AST and ALT in the treatment group and the AST activity in the control group were markedly improved when compared with those before treatment ( P < 0.05 ) .

Compared with the control group , the abnormal lymphocyte positive case number obviously decreased in the treatment group after treatment , at week 4 and 12 of follow-ups ( P < 0.05 ) .

( 4 ) After treatment , at week 4 and 12 of follow-ups , CD3 + and CD8 + significantly decreased ; CD4 + , CD4/CD8 , and B cells significantly increased in the two groups , when compared with before treatment ( P < 0.05 ) .

NK cells significantly increased more in the treatment group after treatment , at week 4 and 12 of follow-ups , higher than before treatment as well as the control group ( P < 0.05 ) .

( 5 ) EB viral DNA and EB viral CA-IgM negative conversion case numbers significantly increased in the two groups after treatment , at week 4 and 12 of follow-ups ( P < 0.05 ) .

Compared with the control group , EB viral DNA and EB viral CA-IgM negative conversion case numbers significantly increased in the treatment group after treatment and at week 4 of follow-ups ( P < 0.05 ) .

Treatment of EB virus infection by Chinese medical treatment was effective .

It could promote the recovery of EB viral infection , and reduce the risk of vicious disease after EB viral infection .

The primary objective was to compare the cosmetic outcomes of traumatic trunk and extremity lacerations repaired using absorbable versus nonabsorbable sutures .

The secondary objective was to compare complication rates between the two groups .

This was a randomized controlled trial comparing wounds repaired with Vicryl Rapide and Prolene sutures .

Pediatric and adult patients with lacerations were enrolled in the study .

At a 10-day follow-up , the wounds were evaluated for infection and dehiscence .

After 3 months , patients returned to have the wounds photographed .

Two plastic surgeons blinded to the method of closure rated the cosmetic outcome of each wound using a 100-mm visual analog scale ( VAS ) .

Using a noninferiority design , a VAS score of 13 mm or greater was considered to be a clinically significant difference .

We used a Student 's t-test to compare differences between mean VAS scores and odds ratios ( ORs ) to compare differences in complication rates between the two groups .

Of the 115 patients enrolled , 73 completed the study including 35 in the Vicryl Rapide group and 38 in the Prolene group .

The mean ( SD ) age of patients who completed the study was 22.1 ( 15.5 ) years , and 39 were male .

We found no significant differences in the age , race , sex , length of wound , number of sutures , or layers of repair in the two groups .

The observer 's mean VAS for the Vicryl Rapide group was 54.1 mm ( 95 % confidence interval [ CI ] = 44.5 to 67.0 mm ) and for the Prolene group was 54.5 mm ( 95 % CI = 45.7 to 66.3 mm ) .

The resulting mean difference was 0.5 mm ( 95 % CI = -12.1 to 17.2 mm ; p = 0.9 ) ; thus noninferiority was established .

Statistical testing showed no differences in the rates of complications between the two groups , but a higher percentage of the Vicryl Rapide wounds developed complications .

The use of absorbable sutures for the repair of simple lacerations on the trunk and extremities should be considered as an alternative to nonabsorbable suture repair .

Aspirin early after intravenous thrombolysis in acute ischemic stroke increases the risk of symptomatic intracranial hemorrhage ( SICH ) , without influencing functional outcome at 3 months .

The effect of aspirin on early neurological deterioration ( END ) was explored as a post hoc analysis of the randomized Antiplatelet Therapy in Combination With Recombinant t-PA Thrombolysis in Ischemic Stroke ( ARTIS ) trial .

END , defined as a 4 points National Institutes of Health Stroke Scale worsening 24 hours after intravenous thrombolysis , was categorized into SICH ( ENDSICH ) and cerebral ischemia ( ENDCI ) .

Multinomial logistic regression was used to assess the effect of aspirin on END .

Of the 640 patients , 31 patients ( 4.8 % ) experienced END ( 14 ENDSICH , 17 ENDCI ) .

Aspirin increased the risk of ENDSICH ( odds ratio , 3.73 ; 95 % confidence interval , 1.03-13 .49 ) but not of ENDCI ( odds ratio , 1.14 ; 95 % confidence interval , 0.44-3 .00 ) .

After adjustment for other explanatory variables , the association between aspirin and ENDSICH remained significant .

In this trial , there is no evidence of an early antithrombotic effect from the addition of aspirin to intravenous thrombolysis in acute ischemic stroke .

To compare the relative effectiveness of methotrexate and mycophenolate mofetil for noninfectious intermediate uveitis , posterior uveitis , or panuveitis .

Multicenter , block-randomized , observer-masked clinical trial .

Eighty patients with noninfectious intermediate , posterior , or panuveitis requiring corticosteroid-sparing therapy at Aravind Eye Hospitals in Madurai and Coimbatore , India .

Patients were randomized to receive 25 mg weekly oral methotrexate or 1 g twice daily oral mycophenolate mofetil and were monitored monthly for 6 months .

Oral prednisone and topical corticosteroids were tapered .

Masked examiners assessed the primary outcome of treatment success , defined by achieving the following at 5 and 6 months : ( 1 ) 0.5 + anterior chamber cells , 0.5 + vitreous cells , 0.5 + vitreous haze and no active retinal/choroidal lesions in both eyes , ( 2 ) 10 mg of prednisone and 2 drops of prednisolone acetate 1 % a day , and ( 3 ) no declaration of treatment failure because of intolerability or safety .

Additional outcomes included time to sustained corticosteroid-sparing control of inflammation , change in best spectacle-corrected visual acuity , resolution of macular edema , adverse events , subgroup analysis by anatomic location , and medication adherence .

Forty-one patients were randomized to methotrexate and 39 to mycophenolate mofetil .

A total of 67 patients ( 35 methotrexate , 32 mycophenolate mofetil ) contributed to the primary outcome .

Sixty-nine percent of patients achieved treatment success with methotrexate and 47 % with mycophenolate mofetil ( P = 0.09 ) .

Treatment failure from adverse events or tolerability was not different by treatment arm ( P = 0.99 ) .

There were no differences between treatment groups in time to corticosteroid-sparing control of inflammation ( P = 0.44 ) , change in best spectacle-corrected visual acuity ( P = 0.68 ) , or resolution of macular edema ( P = 0.31 ) .

There was no statistically significant difference in corticosteroid-sparing control of inflammation between patients receiving methotrexate or mycophenolate mofetil .

However , there was a 22 % difference in treatment success favoring methotrexate .

The prevalence of methicillin-resistant Staphylococcus aureus ( MRSA ) respiratory infection in cystic fibrosis ( CF ) has increased dramatically over the last decade , and is now affecting approximately 25 % of patients .

Epidemiologic evidence suggests that persistent infection with MRSA results in an increased rate of decline in FEV1 and shortened survival .

Currently , there are no conclusive studies demonstrating an effective and safe treatment protocol for persistent MRSA respiratory infection in CF.

The primary objective of this study is to evaluate the safety and efficacy of a 28-day course of vancomycin for inhalation in combination with oral antibiotics in eliminating MRSA from the respiratory tract of individuals with CF and persistent MRSA infection .

This is a two-center , randomized , double-blind , comparator-controlled , parallel-group study with 1:1 assignment to either vancomycin for inhalation ( 250mg twice a day ) or taste-matched placebo for 28days in individuals with cystic fibrosis .

In addition , both groups will receive oral rifampin , a second oral antibiotic - trimethoprim/sulfamethoxazole ( TMP/SMX ) or doxycycline , protocol determined - mupirocin intranasal cream , and chlorhexidine body washes .

Forty patients with persistent respiratory tract MRSA infection will be enrolled : 20 will be randomized to vancomycin for inhalation and 20 to a taste-matched placebo .

The primary outcome will be the presence of MRSA in sputum respiratory tract cultures 1month after the conclusion of treatment .

Secondary outcomes include the efficacy of the intervention on : FEV1 % predicted , patient reported outcomes , pulmonary exacerbations , and MRSA colony-forming units found in respiratory tract sample culture .

Results of this study will provide guidance to clinicians regarding the safety and effectiveness of a targeted eradication strategy for persistent MRSA infection in CF.

This trial is registered at ClinicalTrials.gov ( NCT01594827 , received 05/07/2012 ) and is funded by the Cystic Fibrosis Foundation ( Grants : PMEP10K1 and PMEP11K1 ) .

There is a strong association between weight gain and metabolic events in patients with schizophrenia receiving many of the second-generation antipsychotic agents .

We explored the relationship between body mass index ( BMI ) and metabolic events in patients with schizophrenia receiving long-acting injectable paliperidone palmitate ( PP ) in a long-term trial .

We conducted a post hoc analysis of data from a PP study that included a 33-week open-label transition ( TR ) and maintenance phase ; a variable duration , randomized , double-blind ( DB ) , placebo-controlled phase and a 52-week open-label extension ( OLE ) phase .

Overall , 644 patients received PP continuously from study entry through discontinuation or study completion and were grouped by baseline BMI ( kg/m2 ) : underweight ( BMI < 19 ; n = 29 , 4.5 % ) , normal-weight ( BMI 19 - < 25 ; n = 229 , 35.6 % ) , overweight ( BMI 25 - < 30 ; n = 232 , 36.0 % ) and obese ( BMI 30 ; n = 154 , 23.9 % ) .

Metabolic treatment-emergent adverse events ( TEAEs ) and changes in related laboratory results from TR baseline were analyzed .

PP exposure was similar across BMI groups ; overall mean ( SD ) dose/month was 70.3 ( 17.17 ) mg eq .

[ 109.6 ( 26.78 ) mg ] ; median duration of exposure was 204 days ( 6 to 1009 days ) .

Occurrences of metabolic TEAEs overall by group were 0 % ( underweight ) , 14.9 % ( normal-weight ) , 14.7 % ( overweight ) , and 24.0 % ( obese ) .

The most common ( 2 % ) metabolic TEAE were weight gain and elevated blood levels of glucose , lipids , and insulin .

Mean BMI and weight increased in normal-weight and overweight groups at DB endpoint , and in underweight , normal-weight and overweight groups at OLE endpoint ( p 0.05 ) .

No consistent trend for increased metabolic-related laboratory values by baseline BMI group was observed .

Homeostatic model assessments for insulin resistance indicated preexisting insulin resistance at baseline , with minimal changes at OLE endpoint across baseline BMI groups .

Occurrences of metabolic-related TEAEs trended with greater BMI status in patients with schizophrenia treated with PP ; consistent trends in metabolic-related laboratory values were not observed .

This study is registered at ClinicalTrials.gov ( NCT 00518323 ) .

Fecal immunochemical tests ( FITs ) are recommended to screen average-risk adults for colorectal cancer ( CRC ) .

Little research has examined whether a two-sample FIT affects participant uptake , compared with a one-sample FIT .