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Comparison of the safety and effectiveness of human and bovine long-acting insulins. | e; p = NS). The frequency of mild hypoglycemia was 3.0 +/- 0.5 events per week vs 2.0 +/- 0.3 (p = NS). No severe hypoglycemia occurred. There were no differences between blood glucose daily profiles; insulin doses; hemoglobin Alc (8.6 +/- 0.4% BID vs. 8.4 +/- 0.3% QD injections) and occurrence of hypoglycemia between the single and two-dose long-acting regimens. These data indicate that long-acting semi-synthetic human insulin (a) can be effectively used as a once daily injection; (b) may be more biologica | 2635094 | [
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Comparison of the safety and effectiveness of human and bovine long-acting insulins. | lly active than bovine; and (c) can be associated with safe and effective diabetes control. | 2635094 | [
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Variability of three standard neurophysiological techniques in established symptomatic diabetic polyneuropathy. | The reproducibility of three standard neurophysiological techniques (motor and sensory nerve conduction velocities; vibration perception threshold and mean expiratory: inspiratory electrocardiographic R-R ratio) was determined from duplicate measurements approximately four weeks apart in 50 patients with chronic symptomatic diabetic polyneuropathy. There was no change in average glycaemic control (mean +/- SD) between the measurements (HbA1 10.7 +/- 2.0 vs. 10.4 +/- 2.1% at zero and four weeks respectively) | 2635095 | [
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Variability of three standard neurophysiological techniques in established symptomatic diabetic polyneuropathy. | . While there were no significant differences in the mean values at zero and four weeks for any technique considerable intra-individual variability was observed in several measurements. Mean coefficients of variation (CV) for motor nerve conduction velocity ranged from 9.8% (ulnar nerve) to 10.7% (median) to 12.2% (peroneal nerve). Variability in sensory nerve conduction velocities (CVs 8.6; 8.7 and 14.7% for radial; ulnar and sural nerves respectively) was complicated by a high proportion of unrecordable a | 2635095 | [
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Variability of three standard neurophysiological techniques in established symptomatic diabetic polyneuropathy. | ction potentials. Duplicate action potentials were recordable from the sural nerve in only 15 (30%) patients. The highest intra-individual variability was observed in measurements of vibration perception threshold with CVs of 21.0% (thumb) and 18.0% (hallux). The apparently satisfactory CV of 3.6% for the cardiac E:I ratio test may represent an artefactually low degree of variability. Neurophysiological techniques in current use are characterized by technical limitations and intra-individual variability in | 2635095 | [
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Endodontic status and suggested treatment in a population requiring substantial dental care. | The purpose of this study was to analyse endodontic status and treatment suggested for Swedish citizens requiring substantial dental care. According to the Swedish dental insurance system; treatment plans including radiographs have to be submitted for approval if the estimated cost of treatment exceeds a certain level (USD 500 in 1977). A sample of 1094 treatment plans received during 1977 and 1978 was randomly selected. In the radiographs the number of remaining teeth was recorded; periapical condition was | 2635106 | [
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Endodontic status and suggested treatment in a population requiring substantial dental care. | evaluated and the quantity and quality of previous endodontic treatment were estimated. In addition; treatment plans concerning the teeth with periapical lesions were studied. The results indicated that patients analysed in this study that needed expensive treatment had more missing teeth; more root-filled teeth and more teeth with periapical lesions than what has been reported in previous studies of samples supposed to accurately represent the Swedish population. However; the technical quality of the root | 2635106 | [
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Endodontic status and suggested treatment in a population requiring substantial dental care. | fillings and the frequency of periapical lesions in root-filled teeth were the same as in previous studies; with high frequencies of inadequate root fillings and related unfavourable responses. Thus the patients in this study retained a significant need for endodontic treatment despite having already received a great deal of endodontic care. Further; it was found that nearly half of the observed periapical lesions would not be treated based on the submitted plans. | 2635106 | [
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The alkalizing properties of calcium hydroxide compounds. | Calcium hydroxide compounds are available in various forms; such as in aqueous suspensions or as cements; liners; pastes or filled resins. When such compounds are exposed to water; the calcium hydroxide dissociates and the pH value shifts to the basic. In this study the compounds Pulpdent; Dycal; Hydroxyline; Gangraena Merz and Prisma VLC-Dycal were subjected to analysis; including quantitative measurement of the amount and the chronological course of ion release following exposure to water; qualitative ana | 2635105 | [
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The alkalizing properties of calcium hydroxide compounds. | lysis of the alkalizing effects at the dentin surface and examination of antimicrobial properties. The results showed that calcium hydroxide compounds differed greatly. The strongest degree of ion release; combined with definite antimicrobial properties; was found for the aqueous calcium hydroxide suspension (Pulpdent). The cement (Dycal) demonstrated significantly weaker activity. The liner and the paste (Hydroxyline and Gangraena Merz); as well as the calcium hydroxide filled resin (Prisma VLC-Dycal); wer | 2635105 | [
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An enigmatic sinus tract origin. | Diagnosis of the origin of a sinus tract is very complex. In this case report; a sinus tract stoma appeared above the left maxillary incisor; but the causative tooth was the right maxillary incisor. Incorrect diagnosis led to endodontic treatment of a healthy tooth followed by apicoectomy; which was also ineffective. An endodontic consultation revealed the true origin of the sinus tract. Five days after completing conservative endodontic treatment of the right maxillary incisor; the sinus tract disappeared. | 2635107 | [
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An enigmatic sinus tract origin. | This case confirms the need to include a diagnostic tracing radiograph as part of routine diagnostic procedures. | 2635107 | [
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A preliminary malaria survey in Bisra PHC, district Sundergarh, Orissa. | nan | 2635109 | [
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Studies on malaria and filariasis vectors in Kamorta and Great Nicobar Islands. | A total of 1401 adult mosquitoes mainly dominated by Anopheles sundaicus (40.18%) and Culex quinquefasciatus (57.31%) were collected from Kamorta and Great Nicobar Islands. It was revealed from human bait collection that both species prevailed almost all through the night (density 8.1/man hour) with a peak around midnight. Mixed breeding of A. sundaicus with A. vagus; Cx. quinquefasciatus; Cx. bitaeniorhynchus and Cx. tritaeniorhynchus was observed at many places. Adult A. sundaicus were found highly suscep | 2635108 | [
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Studies on malaria and filariasis vectors in Kamorta and Great Nicobar Islands. | tible to DDT and larvae to Temephos (Abate). Cx. quinquefasciatus was resistant to DDT (31% mortality). High parity of A. sundaicus (40.42%) is an indication of the vectorial potential of this species to sustain malaria transmission in these islands. | 2635108 | [
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Excellence in dentistry: mandibular repositioning appliances. | nan | 2635114 | [
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More patients from internal or external marketing? | nan | 2635115 | [
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Emulsion clearing characteristics in the processing of dental radiographic films. | Recent problems in the fixation of dental X-ray films during processing have led to a study of the clearing of dental emulsions. A method has been devised to compare the behaviour of different emulsions and fixing chemistry under varying conditions of time and temperature. The ease with which emulsions clear has been shown to relate to the fixer chemistry; temperature and time of fixation and; for D-speed films; to the speed of the emulsion. The density of the residual silver halide is approximately inverse | 2635118 | [
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Emulsion clearing characteristics in the processing of dental radiographic films. | ly proportional to the time and temperature for the ranges explored. E-speed emulsion was less affected than D-speed by fixer chemistry; time and temperature. Fixation is relatively less influenced by temperature changes than development. A suspected relationship between clearing ability and emulsion thickness has not been demonstrated reliably in this investigation. The evaluation of these variables is of relevance to those concerned with the manufacture of films; processors; and processing chemistry as we | 2635118 | [
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Emulsion clearing characteristics in the processing of dental radiographic films. | ll as to those who process X-ray films. | 2635118 | [
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] |
Standard forms of dentition and mandible for applications in rotational panoramic radiography. | Mathematical expressions describing the average form and size of the dentition and the mandible are presented. These expressions should be of value in applications of panoramic radiography when reference to an average standard jaw form is of interest. Data were collected from axial radiographs of 35 males and 35 females of three ethnic groups: Mexican-Americans; black Americans and American and Scandinavian Caucasians. Curves were traced on the axial radiographs representing the dentition and the mandible a | 2635119 | [
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Standard forms of dentition and mandible for applications in rotational panoramic radiography. | nd points along these curves digitized. Mathematical expressions were established using advanced algorithms for orthogonal polynomial curve fitting; i.e. perpendicular distances to the curved dentition and mandible were minimized rather than distances parallel to the y-axis in an arbitrarily chosen coordinate system. The standard deviations around the polynomials defining the average curves are demonstrated and expressions for calculating the continuously varying standard deviations are given. | 2635119 | [
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Accuracy of radiographic caries diagnosis using different X-ray generators. | Dental X-ray machines utilizing five different combinations of X-ray generators and tube voltages (Philips Oralix 65 kV; Siemens Heliodent EC 60 kV; Siemens Heliodent 70 kV; Soredex Minray DC 60 kV and Soredex Minray DC 70 kV) were compared with respect to the accuracy of radiographic diagnosis of proximal caries. Nine observers diagnosed proximal caries in radiographs of extracted premolars. The findings of the observers were compared to the actual presence or absence of caries. The ROC-curve technique was | 2635120 | [
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Accuracy of radiographic caries diagnosis using different X-ray generators. | used to evaluate differences in diagnostic accuracy between the X-ray machines. The results showed small differences in diagnostic accuracy between the different X-ray generators but they proved to be statistically non-significant. | 2635120 | [
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Comparison between panoramic and periapical radiography in the diagnosis of periodontal bone loss. | Panoramic and periapical radiography was performed on 100 patients. Five observers each registered the scores for marginal bone level; presence of bone defects and furcation involvement in the radiographs of 20 patients and the results were compared. The overall concordance in scoring the marginal bone level was high when panoramic and periapical radiography was compared. In the upper arch; 66% of the sites showed concordant scores; 31% deviated by one and 3% by two score-points. In the lower arch; 74% of s | 2635121 | [
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Comparison between panoramic and periapical radiography in the diagnosis of periodontal bone loss. | ites had concordant scores; 25% deviated by one and 1% by two score-points. The panoramic radiographs more often indicated a more severe bone loss than the periapical radiographs. The concordance was related to the degree of bone loss. In sites with no bone loss the concordance was high whereas it was lower in those with severe bone loss. The concordance of the two radiographic methods for the mandibular canine; premolars and first molar was equally as high as the intra-observer overall agreement; but lowes | 2635121 | [
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Comparison between panoramic and periapical radiography in the diagnosis of periodontal bone loss. | t for the mandibular central incisors and the maxillary molars. Bone defects were more easily identified by periapical radiography. | 2635121 | [
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A preventive dentistry component in the curriculum of Israeli dental students. | A preventive dentistry program conducted by 34 and 27 senior dental students as an integral part of children's clinic was evaluated. At the initial meeting of the three-session program; dental knowledge and oral hygiene levels were all 265 participating children. Follow-up who had participated in the prevent program the previous year and were now continuing their treatments; demonstrated significantly improved dental knowledge oral hygiene as compared to new patients. All of the children demonstrated signif | 2635117 | [
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A preventive dentistry component in the curriculum of Israeli dental students. | icantly improved dental knowledge and oral hygiene at the final session of the program. The effectiveness on the participating children; this program was also successful in being accepted by students and faculty as a regular component of the clinical curriculum. The model presented here will be modified and improved on for future continued implementation. | 2635117 | [
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Diagnostic value of computed tomography in parotid tumours. | In 18 cases of parotid tumours; CT demonstrated their primary site; extent and invasion of surrounding tissue precisely. It was valuable in the majority of cases in differentiating benign from malignant tumours and could distinguish accurately intrinsic from extrinsic. CT sialography was superior in equivocal cases when it made the tumour easier to identify and the diagnosis more accurate. | 2635122 | [
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Temporomandibular degenerative joint disease in children and adolescents: report of eight cases. | The prevalence of degenerative joint disease (DJD); of the temporomandibular joint (TMJ) in adolescents and its clinical and radiographic presentation has not been widely described. During a 2-year period; 174 patients with TMJ pain or dysfunction were referred to the Division of Oral Radiology; College of Dentistry; University of Saskatchewan; for radiographic evaluation. Twenty-one patients were 18 years or younger and; of these; eight were diagnosed as having DJD of one or both joints on the basis of the | 2635123 | [
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Temporomandibular degenerative joint disease in children and adolescents: report of eight cases. | radiographic appearances. The clinical and radiographic features of these eight adolescent patients are described and the factors potentially associated with the development of the condition discussed. The prevalence in this study appeared to be higher than previously reported. | 2635123 | [
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Fracture of the hyoid bone presenting as a dislocated mandible. | A case report is presented of a fractured hyoid bone which was missed in the first instance and incorrectly diagnosed as a dislocation of the mandible. | 2635124 | [
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Odontogenic keratocyst of the maxilla: a diagnostic problem. | A case is reported of an 11-year-old boy with a space-occupying lesion in the left maxilla: the radiographic appearances were consistent with either fibrous dysplasia or an adenomatoid odontogenic tumour but the histology proved it to be an odontogenic keratocyst. | 2635125 | [
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Evaluation of alkali treatment for biodegradation of corn cobs by Aspergillus niger. | Effect of NaOH pretreatment on the biodegradation of corn cobs for the production of cellulase and protein was studied using Aspergillus niger. Delignification of cobs with NaOH remarkably increased the production of cellulase and protein. Treatment of cobs with 2% NaOH was found to be the best with respect to their susceptibility to biodegradation for maximum production of cellulose 1;4-beta-cellobiosidase; cellulase; beta-glucosidase soluble protein and crude protein; this also led to the highest protein | 2635128 | [
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Evaluation of alkali treatment for biodegradation of corn cobs by Aspergillus niger. | recovery; maximum cellulose utilization and also for the maximum degradation of substrate. | 2635128 | [
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Struvite crystal precipitation by different phenotypes of Yersinia. | Extracellular formation of struvite crystals by Yersinia enterocolitica; Y. frederiksenii; Y. kristensenii and Y intermedia strains was investigated. Precipitation of crystalline structures was found with 19 of the 187 strains tested; its formation being more frequently observed at 25 degrees C than at 37 degrees C. Production of struvite was greater in Y. enterocolitica strains belonging to biotype 1; serogroup 0:7;8 and lysotype Xz; than observed in other phenotypes. Quantitative assay in a liquid medium | 2635129 | [
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Struvite crystal precipitation by different phenotypes of Yersinia. | showed that struvite formation began after 3 d of incubation; production of these crystals increased up to 15 d. Crystalline structures were examined using electron microscopy and their extracellular formation was observed. | 2635129 | [
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Orthodontic diagnosis. Part 2: Dental. | nan | 2635126 | [
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] |
Compounds isolated at the Department of Biogenesis of Natural Substances, Institute of Microbiology, Czechoslovak Academy of Sciences, in 1984-1988. | A total of 41 compounds studied at the Department of Biogenesis of Natural Substances between 1984 and 1988 are characterized and tabulated. They include natural; semisynthetic and synthetic compounds. | 2635131 | [
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Inhibition of yeast-mycelium transformation by 2-alkylthio-6-amino- and 2-alkylthio-6-formamidobenzothiazoles and their in vitro antifungal activity. | The antifungal effect of 2-alkylthio-6-amino- and 2-alkylthio-6-formamidobenzothiazoles (22 derivatives in all) on Aspergillus niger and various Candida yeasts was tested. No significant effect was observed with A. niger. With the pathogenic yeast species C. albicans and C. guilliermondii; the most efficient derivatives (6-formamido-2-propylthio-; 6-formamido-2-butylthio-; 6-formamido-2-butylthio-; 6-formamido-2-penthylthio- and 6-formamido-2-isopentylthiobenzothiazole) exhibited ED50 values in the range fr | 2635130 | [
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Inhibition of yeast-mycelium transformation by 2-alkylthio-6-amino- and 2-alkylthio-6-formamidobenzothiazoles and their in vitro antifungal activity. | om 2.2 to 21 mg/L and were thus 3-35 times more efficient than 2-mercaptobenzothiazole (Dermacid) that is normally used. 6-Amino-2-pentylthiobenzothiazole was found to be an efficient specific inhibitor of the transformation of the yeast form of C. albicans to its mycelial one; IC95(M) being 10 mg/L; which was a concentration 25 times lower than MICY+M. | 2635130 | [
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Effect of granaticin on the activity of DNA-directed RNA polymerase from Streptomyces granaticolor. | DNA-directed RNA polymerase was isolated from wild-type and mutant (asporogenic and granaticin overproducing) Streptomyces granaticolor. The effect of granaticin on the enzyme activity was compared with that of standard transcription inhibitors; rifampicin and rifamycin SV and shown to be zero. | 2635132 | [
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Regulation of nebramycin biosynthesis by inorganic phosphate. | The effect of inorganic phosphate on the biosynthesis of nebramycin factors 2; 4 and 5' was studied in Streptomyces tenebrarius strain A (forming 2; 4 and 5' in natural ratios) and its mutants B (forming predominantly 2); C (forming 2 as the only major product) and D (forming predominantly 5'). In phosphate-supplemented complex media; the production of 2 in A; B and C was reduced by 20-70%; while the yields of 5' remained unchanged in A and decreased by 30-60% in B. The production of 4 increased by 50-90% i | 2635133 | [
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Regulation of nebramycin biosynthesis by inorganic phosphate. | n A and was fully suppressed in B. In D the biosynthesis of the three factors was inhibited completely. | 2635133 | [
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Effects of seat slope and hip flexion on spinal angles in sitting. | Lumbar and thoracic spinal angles of 25 male and 25 female subjects were measured in four sitting postures; with standing angles used as reference. Subjects sat with either 90 deg or 65 deg of hip flexion on either flat or forward-sloping seats. Lumbar kyphosis was greatest when the flat seat/90-deg posture was adopted and least when the sloping seat/65-deg posture was adopted. The opposite was observed for the thoracic angles; and intermediate results were observed for the other two sitting postures. No st | 2635135 | [
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Effects of seat slope and hip flexion on spinal angles in sitting. | atistically significant interactions were observed among seat slope; hip flexion; and subject sex. The findings are discussed with reference to the anatomy of sitting and factors influencing pelvic tilt and the implications for the ergonomic design of chairs. | 2635135 | [
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Trends in finger pinch strength in children, adults, and the elderly. | This study explores empirical relationships among different types of pinches in three age groups. Peak maximum voluntary forces of several pinches--lateral; chuck; and pulp pinches with digits 2; 3; 4; and 5-were tested in 182 subjects comprising 62 children (5-12 years); 70 adults (18-40 years); and 50 elderly (60-89 years). Analysis of the forces indicated four groups of strength magnitude: (1) lateral and chuck; (2) pulp 2 and 3; (3) pulp 4; and (4) pulp 5; in that order; the strength of each type of pin | 2635136 | [
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Trends in finger pinch strength in children, adults, and the elderly. | ch bears a definite quantitative relationship to every other type; regardless of age group or gender. The female-to-male strength ratio was greatest in children (89%) and least in adults (69%). Comparison with other pinch strength studies established that although force magnitudes may be strongly influenced by specific experimental conditions; empirical relationships among different pinch forces are fairly stable and predictable. | 2635136 | [
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[A thioridazine-dihydroergotoxine combination in the treatment of senile pruritus]. | Senile itching; a peculiar clinical situation consisting of a cutaneous senile involution associated with a relevant neurogenic component; still keeps being a difficult therapeutic problem. For the purpose; a clinical trial; carried out with a combination of thioridazine and dihydroergotoxine on 19 patients carriers of the affection; could show a relevant decrease in all parameters assessed; ie itching; muscle tension and skin temperature measured by biofeedback. The combination also showed a good tolerance | 2635137 | [
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[A thioridazine-dihydroergotoxine combination in the treatment of senile pruritus]. | . | 2635137 | [
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[Flurbiprofen in gel: study of acceptability, tolerability and evaluation of its allergenic potential]. | The study aimed to assess the allergenic capacity of gel-based flurbiprofen in healthy volunteers; and then evaluate its acceptance and tolerability in patients affected by various skin diseases. Twenty-five healthy volunteers of both sexes (age range: 19-35 years) were included in the first phase of the study. Allergenic capacity was evaluated using Kligman's maximization test in which 5 patch tests were carried out on the same site using a solution of 2.5% lauryl sulphate; followed by patch tests using ge | 2635138 | [
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[Flurbiprofen in gel: study of acceptability, tolerability and evaluation of its allergenic potential]. | l-based flurbiprofen. Control tests were performed 15 days later. The second phase of the study comprised 15 hospitalised patients; with an age range of between 18 and 70 years; affected by psoriasis and eczema. All patients were treated with gel-based 5% flurbiprofen twice daily for 2 weeks. Patients were asked to fill in a questionnaire in order to assess the acceptance and tolerability of the drug. Only one subject in the first group showed an allergic response to the drug. Adverse effects were observed | 2635138 | [
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[Flurbiprofen in gel: study of acceptability, tolerability and evaluation of its allergenic potential]. | in two patients in the second group. Drug acceptance was excellent. | 2635138 | [
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[Efficacy of fenticonazole in patients with pityriasis versicolor]. | Thirty patients suffering from Pityriasis versicolor were treated with fenticonazole in cream or lotion form with two applications a day. At microscopy; Malassezia furfur was encountered in 25 cases and Pityrosporum orbiculare in 5. Disappearance of the yeast was obtained on average in 2 weeks of treatment. Measurement of sebum content with a Sebumeter apparatus did not reveal significant difference (p greater than 0.05) between patients suffering from Pityriasis versicolor and controls and in treated patie | 2635139 | [
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[Usefulness and limitations of the evaluation of sex-hormone-binding globulin in women with a female pattern of androgen-induced baldness]. | Sex-hormone binding globulin (SHBG) and androgen serum levels have been evaluated in a homogeneous group of women with female pattern of androgenetic alopecia (AA); stage II; without any clinical or anamnestic evidence of acne; hirsutism; irregular menses. Results did not show any significant difference between patients and controls. Since SHBG levels are androgen-dependent; the discordant results of previous published series regarding women with AA could be related to the presence of a variable number of p | 2635140 | [
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[Usefulness and limitations of the evaluation of sex-hormone-binding globulin in women with a female pattern of androgen-induced baldness]. | atients with clinical and/or anamnestic evidence of a "cryptic" hyperandrogenism in some series; and to their absence in others. Statistically significant low average SHBG values could have been sustained by a mild; heterogeneous and not significant androgen excess. In our opinion the genetically-determined response of the target organ to androgens seems to play the major pathogenetic role in AA; at least when the woman does not reveal any clinical or anamnestic evidence of cryptic or clear hyperandrogenism | 2635140 | [
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] |
[Dermatologic problems in patients undergoing liver transplantation]. | Skin troubles were studied in 28 liver transplant patients treated with immunosuppressive agents. Skin complications ranged from minor annoyances to life-threatening conditions. The frequency of dermatologic problems needs periodic examinations by a dermatologist. | 2635141 | [
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[A non-invasive method for measuring the visco-elastic properties of the skin in healthy subjects and in subjects with scleroderma]. | The skin elasticity is a mechanic parameter of great interest for the objective evaluation of many skin disorders. The Authors present a non invasive method for the determination of skin visco-elastic properties. Four sclerodermic patients and 18 normal subjects were studied. | 2635142 | [
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Construction of chickpea genomic library. | For construction of chickpea genomic library; DNA was isolated; purified on CsCl gradient and size fractionated into 15-20 Kb fragments after restriction with Sau 3A. These fragments were ligated to phage lambda (EMBL-3) vector and the recombinant molecules packaged in vitro into viable phage particles. The recombinant phages were obtained as phages on a P2 lysogen of E. coli (Spi- selection) and amplified to establish a permanent library. This is the first report of the construction of chickpea genomic lib | 2635143 | [
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Chromatid association in acrocentric chromosomes of abnormal sexual development (ASD) cases. | Concordant/discordant associations at chromatid level were compared and found significant (P less than 0.05) in females with primary amenorrhea. This probably suggested that the acrocentric association pattern in this group of ASD and infertility did not follow a random segregation in subsequent cell divisions and that the concordant acrocentric chromosomes have regularly established physical connections with one another; held together for several cell cycles. It could only be speculated that the associatio | 2635144 | [
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Chromatid association in acrocentric chromosomes of abnormal sexual development (ASD) cases. | n of acrocentric chromosome anomalies in some females with abnormal sex chromosomes are due to this reason. In the event that chromosome association has a bearing on chromosome aberrations; the non-random pattern of acrocentric association probably would increase the choice for translocation and non disjunction in the somatic cells in females with primary amenorrhea during ontogenesis. | 2635144 | [
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Antifertility effect of Piper betle Linn. extract on ovary and testis of albino rats. | Chronic administration (sc) of the extract of the stalk of P. betle at 30 mg/kg body weight daily for 21 days produced significant decrease in oestrogen and androgen dependent target organ weights along with increase in cholesterol in adrenal; ovary and testis. Acid and alkaline phosphatase activities in serum; liver and kidney did not exhibit any toxic effect. There was marked change in morphology of testis and ovary. Vaginal smear showed prolonged dioestrus in treated female. The treated male showed decre | 2635145 | [
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Antifertility effect of Piper betle Linn. extract on ovary and testis of albino rats. | ased number and motility of sperm. Both male and female remained infertile after treatment suggesting antifertility activity of the extract on both sexes of albino rats. | 2635145 | [
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Comparative study of known nonsteroidal antiinflammatory drugs with glycosidal fraction isolated from Maesa chisia D. don var angustifolia Hook F and Th. | Antiinflammatory; analgesic and antipyretic activities of glycosidal fraction isolated from M. chisia were compared in battery of animal tests with known nonsteroidal antiinflammatory drugs (NSAIDs). The pharmacological activities compared favourably with NSAIDs whereas remarkable lack of toxicity was an added advantage. | 2635146 | [
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Biochemical alterations in rat fetal liver following in utero exposure to di(2-ethylhexyl)phthalate (DEHP). | Oral administration of DEHP; 1000 mg/kg body weight; to rats daily from 6 to 15 day of gestation resulted in retardation of fetal growth and increase in fetal liver weight which contained significant quantities of DEHP. The activities of mitochondrial succinate dehydrogenase; malate dehydrogenase; cytochrome c oxidase and adenosine triphosphatase were decreased in fetal liver. The data indicate that exposure of mothers to DEHP during pregnancy could adversely affect the fetal livers by interfering with bioe | 2635147 | [
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Effect of rapid eye movement sleep deprivation on sexual behaviour of male rats. | Rapid eye movement sleep deprivation for 3 to 4 days by the platform pedestal procedure produced an increase in sexual behaviour of male rats. The possible factors contributing towards the increase in sexual behaviour are discussed. | 2635148 | [
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Effects of repeated eastward and westward synchronizer phase-shifts on growth, blood morphology and biochemical variables in male domestic fowls. | The effects of repeated synchronizer phase-shifts on growth (increment in body weight); blood morphology and growth related biochemical variables in 3-day-old juvenile male chicks were evaluated till they become 20 weeks old. The control birds were kept under a fixed LD 12:12 light schedule throughout; while the LD 12:12 regimen of experimental birds was shifted weekly either by delaying (westward shift) or by advancing (eastward shift) the time of light onset by 8 hr. The rate of growth was more in fowls w | 2635149 | [
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Effects of repeated eastward and westward synchronizer phase-shifts on growth, blood morphology and biochemical variables in male domestic fowls. | hich were exposed to repeated advancement of synchronizer schedule than the controls and those exposed to westward shifts of the synchronizer schedule. Hematological indices; viz.; hemoglobin concentration; number of circulating erythrocytes; hematocrit and biochemical variables; such as concentration of glucose and protein in plasma; glycogen; protein and lipid in liver; and muscle tissues were significantly more in chicks exposed to repeated eastward shifts; when compared with the control birds (LD 12:12) | 2635149 | [
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Effects of repeated eastward and westward synchronizer phase-shifts on growth, blood morphology and biochemical variables in male domestic fowls. | . It is suggested that the eastward shift of the synchronizer may be beneficial for the poultry birds. | 2635149 | [
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Ultrastructural variations in frog muscles subjected to sciatectomy. | Fine structural variations in two different types of muscles of frog (Rana cyanophlictis) subjected to sciatectomy were studied electronmicroscopically. Gastrocnemius muscle showed marked myofibrillar disarray and degeneration due to sciatectomy; while sartorius muscle was relatively less affected. The extent of sciatectomy induced fine structural variation was in proportion to the degree of denervation atrophy (as reflected by loss of wet muscle weight) in these muscles. Differences in the degree of degene | 2635150 | [
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Ultrastructural variations in frog muscles subjected to sciatectomy. | rative changes in atrophying muscles may be attributed to variations in fiber type composition and stretch effects imposed during swimming movements. | 2635150 | [
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Overexpression of beta2-adrenergic receptors in mouse liver alters the expression of gluconeogenic and glycolytic enzymes. | In the livers of humans and many other mammalian species; beta2-adrenergic receptors (beta2-ARs) play an important role in the modulation of glucose production by glycogenolysis and gluconeogenesis. In male mice and rats; however; the expression and physiological role of hepatic beta2-ARs are rapidly lost with development under normal physiological conditions. We previously described a line of transgenic mice; F28 (Andre C; Erraji L; Gaston J; Grimber G; Briand P; and Guillet JG. Eur J Biochem 241: 417-424; | 15585594 | [
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Overexpression of beta2-adrenergic receptors in mouse liver alters the expression of gluconeogenic and glycolytic enzymes. | 1996); which carry the human beta2-AR gene under the control of its own promoter. In these mice; hepatic beta2-AR levels are shown to increase rapidly after birth and; as in humans; be maintained at an elevated level in adulthood. F28 mice display strongly enhanced adenylyl cyclase responses to beta-AR agonists in their livers and; compared with normal mice; have increased basal hepatic adenylyl cyclase activity. In this report we demonstrate that; under normal physiological conditions; this increased beta | 15585594 | [
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Overexpression of beta2-adrenergic receptors in mouse liver alters the expression of gluconeogenic and glycolytic enzymes. | 2-AR activity affects the expression of the gluconeogenic and glycolytic key enzymes phosphoenolpyruvate carboxykinase; glucose-6-phosphatase; and l-pyruvate kinase and considerably decreases hepatic glycogen levels. Furthermore; we show that the effects of beta-adrenergic ligands on liver glycogen observed in humans are reproduced in these mice: liver glycogen levels are strongly decreased by the beta2-AR agonist clenbuterol and increased by the beta-AR antagonist propranolol. These transgenic mice open ne | 15585594 | [
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Overexpression of beta2-adrenergic receptors in mouse liver alters the expression of gluconeogenic and glycolytic enzymes. | w perspectives for studying in vivo the hepatic beta2-AR system physiopathology and for testing the effects of beta-AR ligands on liver metabolism. | 15585594 | [
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Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion. | The importance of mitochondrial biosynthesis in stimulus secretion coupling in the insulin-producing beta-cell probably equals that of ATP production. In glucose-induced insulin secretion; the rate of pyruvate carboxylation is very high and correlates more strongly with the glucose concentration the beta-cell is exposed to (and thus with insulin release) than does pyruvate decarboxylation; which produces acetyl-CoA for metabolism in the citric acid cycle to produce ATP. The carboxylation pathway can increas | 15585595 | [
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Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion. | e the levels of citric acid cycle intermediates; and this indicates that anaplerosis; the net synthesis of cycle intermediates; is important for insulin secretion. Increased cycle intermediates will alter mitochondrial processes; and; therefore; the synthesized intermediates must be exported from mitochondria to the cytosol (cataplerosis). This further suggests that these intermediates have roles in signaling insulin secretion. Although evidence is quite good that all physiological fuel secretagogues stimul | 15585595 | [
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