id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_30000 | split_0_train_30000 | [
{
"id": "split_0_train_30000_passage",
"type": "progene_text",
"text": [
"Northern blot analysis showed that both genes are transcribed , reaching their maximum expression during the exponential phase ."
],
"offsets": [
[
0,
128
]
]
}
] | [] | [] | [] | [] |
split_0_train_30001 | split_0_train_30001 | [
{
"id": "split_0_train_30001_passage",
"type": "progene_text",
"text": [
"Primer extension analysis revealed that apf1 and apf2 harbor a putative promoter sequence that is conserved in all of the genes ."
],
"offsets": [
[
0,
129
]
]
}
] | [
{
"id": "split_0_train_48473_entity",
"type": "progene_text",
"text": [
"apf1"
],
"offsets": [
[
40,
44
]
],
"normalized": []
},
{
"id": "split_0_train_48474_entity",
"type": "progene_text",
"text": [
"apf2"
],
"offsets": [
[
49,
53
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30002 | split_0_train_30002 | [
{
"id": "split_0_train_30002_passage",
"type": "progene_text",
"text": [
"Western blot analysis of the LiCl cell extracts showed that APF proteins are located on the cell surface ."
],
"offsets": [
[
0,
106
]
]
}
] | [
{
"id": "split_0_train_48475_entity",
"type": "progene_text",
"text": [
"APF"
],
"offsets": [
[
60,
63
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30003 | split_0_train_30003 | [
{
"id": "split_0_train_30003_passage",
"type": "progene_text",
"text": [
"Intact cells of L. johnsonii revealed the typical cell wall architecture of S-layer - carrying gram - positive eubacteria , which could be selectively removed with LiCl treatment ."
],
"offsets": [
[
0,
180
]
]
}
] | [] | [] | [] | [] |
split_0_train_30004 | split_0_train_30004 | [
{
"id": "split_0_train_30004_passage",
"type": "progene_text",
"text": [
"In addition , the amino acid composition , physical properties , and genetic organization were found to be quite similar to those of S-layer proteins ."
],
"offsets": [
[
0,
151
]
]
}
] | [] | [] | [] | [] |
split_0_train_30005 | split_0_train_30005 | [
{
"id": "split_0_train_30005_passage",
"type": "progene_text",
"text": [
"These results suggest that APF is a novel surface protein of the Lactobacillus acidophilus B-homology group which might belong to an S-layer - like family ."
],
"offsets": [
[
0,
156
]
]
}
] | [
{
"id": "split_0_train_48476_entity",
"type": "progene_text",
"text": [
"APF"
],
"offsets": [
[
27,
30
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30006 | split_0_train_30006 | [
{
"id": "split_0_train_30006_passage",
"type": "progene_text",
"text": [
"The DNA methyltransferase - like protein DNMT3L stimulates de novo methylation by Dnmt3a ."
],
"offsets": [
[
0,
90
]
]
}
] | [
{
"id": "split_0_train_48477_entity",
"type": "progene_text",
"text": [
"DNA methyltransferase"
],
"offsets": [
[
4,
25
]
],
"normalized": []
},
{
"id": "split_0_train_48478_entity",
"type": "progene_text",
"text": [
"DNMT3L"
],
"offsets": [
[
41,
47
]
],
"normalized": []
},
{
"id": "split_0_train_48479_entity",
"type": "progene_text",
"text": [
"Dnmt3a"
],
"offsets": [
[
82,
88
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30007 | split_0_train_30007 | [
{
"id": "split_0_train_30007_passage",
"type": "progene_text",
"text": [
"Dnmt3L is required for the establishment of maternal methylation imprints at imprinting centers ( ICs ) ."
],
"offsets": [
[
0,
105
]
]
}
] | [
{
"id": "split_0_train_48480_entity",
"type": "progene_text",
"text": [
"Dnmt3L"
],
"offsets": [
[
0,
6
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30008 | split_0_train_30008 | [
{
"id": "split_0_train_30008_passage",
"type": "progene_text",
"text": [
"Dnmt3L , however , lacks the conserved catalytic domain common to DNA methyltransferases ."
],
"offsets": [
[
0,
90
]
]
}
] | [
{
"id": "split_0_train_48481_entity",
"type": "progene_text",
"text": [
"Dnmt3L"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "split_0_train_48482_entity",
"type": "progene_text",
"text": [
"DNA methyltransferases"
],
"offsets": [
[
66,
88
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30009 | split_0_train_30009 | [
{
"id": "split_0_train_30009_passage",
"type": "progene_text",
"text": [
"In an attempt to define its function , we coexpressed DNMT3L with each of the two known de novo methyltransferases , Dnmt3a and DNMT3B , in human cells and monitored de novo methylation by using replicating minichromosomes carrying various ICs as targets ."
],
"offsets": [
[
0,
256
]
]
}
] | [
{
"id": "split_0_train_48483_entity",
"type": "progene_text",
"text": [
"DNMT3L"
],
"offsets": [
[
54,
60
]
],
"normalized": []
},
{
"id": "split_0_train_48484_entity",
"type": "progene_text",
"text": [
"methyltransferases"
],
"offsets": [
[
96,
114
]
],
"normalized": []
},
{
"id": "split_0_train_48485_entity",
"type": "progene_text",
"text": [
"Dnmt3a"
],
"offsets": [
[
117,
123
]
],
"normalized": []
},
{
"id": "split_0_train_48486_entity",
"type": "progene_text",
"text": [
"DNMT3B"
],
"offsets": [
[
128,
134
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30010 | split_0_train_30010 | [
{
"id": "split_0_train_30010_passage",
"type": "progene_text",
"text": [
"Coexpression of DNMT3L with DNMT3B led to little or no change in target methylation ."
],
"offsets": [
[
0,
85
]
]
}
] | [
{
"id": "split_0_train_48487_entity",
"type": "progene_text",
"text": [
"DNMT3L"
],
"offsets": [
[
16,
22
]
],
"normalized": []
},
{
"id": "split_0_train_48488_entity",
"type": "progene_text",
"text": [
"DNMT3B"
],
"offsets": [
[
28,
34
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30011 | split_0_train_30011 | [
{
"id": "split_0_train_30011_passage",
"type": "progene_text",
"text": [
"However , coexpression of DNMT3L with Dnmt3a resulted in a striking stimulation of de novo methylation by Dnmt3a ."
],
"offsets": [
[
0,
114
]
]
}
] | [
{
"id": "split_0_train_48489_entity",
"type": "progene_text",
"text": [
"DNMT3L"
],
"offsets": [
[
26,
32
]
],
"normalized": []
},
{
"id": "split_0_train_48490_entity",
"type": "progene_text",
"text": [
"Dnmt3a"
],
"offsets": [
[
38,
44
]
],
"normalized": []
},
{
"id": "split_0_train_48491_entity",
"type": "progene_text",
"text": [
"Dnmt3a"
],
"offsets": [
[
106,
112
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30012 | split_0_train_30012 | [
{
"id": "split_0_train_30012_passage",
"type": "progene_text",
"text": [
"Stimulation was observed at maternally methylated ICs such as small nuclear ribonucleoprotein polypeptide N ( SNRPN ) , Snrpn , and Igf2rAir , as well as at various nonimprinted sequences present on the episomes ."
],
"offsets": [
[
0,
213
]
]
}
] | [
{
"id": "split_0_train_48492_entity",
"type": "progene_text",
"text": [
"small nuclear ribonucleoprotein polypeptide N"
],
"offsets": [
[
62,
107
]
],
"normalized": []
},
{
"id": "split_0_train_48493_entity",
"type": "progene_text",
"text": [
"SNRPN"
],
"offsets": [
[
110,
115
]
],
"normalized": []
},
{
"id": "split_0_train_48494_entity",
"type": "progene_text",
"text": [
"Snrpn"
],
"offsets": [
[
120,
125
]
],
"normalized": []
},
{
"id": "split_0_train_48495_entity",
"type": "progene_text",
"text": [
"Igf2rAir"
],
"offsets": [
[
132,
140
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30013 | split_0_train_30013 | [
{
"id": "split_0_train_30013_passage",
"type": "progene_text",
"text": [
"Stimulation of Dnmt3a by DNMT3L was also observed at endogenous sequences in the genome ."
],
"offsets": [
[
0,
89
]
]
}
] | [
{
"id": "split_0_train_48496_entity",
"type": "progene_text",
"text": [
"Dnmt3a"
],
"offsets": [
[
15,
21
]
],
"normalized": []
},
{
"id": "split_0_train_48497_entity",
"type": "progene_text",
"text": [
"DNMT3L"
],
"offsets": [
[
25,
31
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30014 | split_0_train_30014 | [
{
"id": "split_0_train_30014_passage",
"type": "progene_text",
"text": [
"Therefore , DNMT3L acts as a general stimulatory factor for de novo methylation by Dnmt3a ."
],
"offsets": [
[
0,
91
]
]
}
] | [
{
"id": "split_0_train_48498_entity",
"type": "progene_text",
"text": [
"DNMT3L"
],
"offsets": [
[
12,
18
]
],
"normalized": []
},
{
"id": "split_0_train_48499_entity",
"type": "progene_text",
"text": [
"Dnmt3a"
],
"offsets": [
[
83,
89
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30015 | split_0_train_30015 | [
{
"id": "split_0_train_30015_passage",
"type": "progene_text",
"text": [
"The implications of these findings for the function of DNMT3L and Dnmt3a in DNA methylation and genomic imprinting are discussed ."
],
"offsets": [
[
0,
130
]
]
}
] | [
{
"id": "split_0_train_48500_entity",
"type": "progene_text",
"text": [
"DNMT3L"
],
"offsets": [
[
55,
61
]
],
"normalized": []
},
{
"id": "split_0_train_48501_entity",
"type": "progene_text",
"text": [
"Dnmt3a"
],
"offsets": [
[
66,
72
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30016 | split_0_train_30016 | [
{
"id": "split_0_train_30016_passage",
"type": "progene_text",
"text": [
"Apolipoprotein E and H polymorphisms in Mongolian Buryat : allele frequencies and relationship with plasma lipid levels ."
],
"offsets": [
[
0,
121
]
]
}
] | [
{
"id": "split_0_train_48502_entity",
"type": "progene_text",
"text": [
"Apolipoprotein E and H"
],
"offsets": [
[
0,
22
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30017 | split_0_train_30017 | [
{
"id": "split_0_train_30017_passage",
"type": "progene_text",
"text": [
"A Buryat population consisting of seven tribal groups in eastern Mongolia has been screened to determine the frequency distribution of different apolipoprotein E and H alleles ( APOE and APOH , genes ) coding for common isoforms and their association with quantitative plasma lipid levels ."
],
"offsets": [
[
0,
290
]
]
}
] | [
{
"id": "split_0_train_48503_entity",
"type": "progene_text",
"text": [
"apolipoprotein E and H"
],
"offsets": [
[
145,
167
]
],
"normalized": []
},
{
"id": "split_0_train_48504_entity",
"type": "progene_text",
"text": [
"APOE"
],
"offsets": [
[
178,
182
]
],
"normalized": []
},
{
"id": "split_0_train_48505_entity",
"type": "progene_text",
"text": [
"APOH"
],
"offsets": [
[
187,
191
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30018 | split_0_train_30018 | [
{
"id": "split_0_train_30018_passage",
"type": "progene_text",
"text": [
"Allele frequencies at the APOE locus in 125 healthy Buryat aged 17 to 73 years were highest for APOE*3 ( 0.804 ) , followed by APOE*4 ( 0.164 ) and APOE*2 ( 0.032 ) ."
],
"offsets": [
[
0,
166
]
]
}
] | [
{
"id": "split_0_train_48506_entity",
"type": "progene_text",
"text": [
"APOE"
],
"offsets": [
[
26,
30
]
],
"normalized": []
},
{
"id": "split_0_train_48507_entity",
"type": "progene_text",
"text": [
"APOE*3"
],
"offsets": [
[
96,
102
]
],
"normalized": []
},
{
"id": "split_0_train_48508_entity",
"type": "progene_text",
"text": [
"APOE*4"
],
"offsets": [
[
127,
133
]
],
"normalized": []
},
{
"id": "split_0_train_48509_entity",
"type": "progene_text",
"text": [
"APOE*2"
],
"offsets": [
[
148,
154
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30019 | split_0_train_30019 | [
{
"id": "split_0_train_30019_passage",
"type": "progene_text",
"text": [
"The APOH locus had high frequencies of APOH*2 ( 0.912 ) and APOH*3 ( 0.088 ) ."
],
"offsets": [
[
0,
78
]
]
}
] | [
{
"id": "split_0_train_48510_entity",
"type": "progene_text",
"text": [
"APOH"
],
"offsets": [
[
4,
8
]
],
"normalized": []
},
{
"id": "split_0_train_48511_entity",
"type": "progene_text",
"text": [
"APOH*2"
],
"offsets": [
[
39,
45
]
],
"normalized": []
},
{
"id": "split_0_train_48512_entity",
"type": "progene_text",
"text": [
"APOH*3"
],
"offsets": [
[
60,
66
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30020 | split_0_train_30020 | [
{
"id": "split_0_train_30020_passage",
"type": "progene_text",
"text": [
"APOH*1 was not detected ."
],
"offsets": [
[
0,
25
]
]
}
] | [
{
"id": "split_0_train_48513_entity",
"type": "progene_text",
"text": [
"APOH*1"
],
"offsets": [
[
0,
6
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30021 | split_0_train_30021 | [
{
"id": "split_0_train_30021_passage",
"type": "progene_text",
"text": [
"No significant differences were observed in the overall APOE allele frequencies between the Buryat and the Siberian Evenki , Inuits , and Indians in Asia , or with some European whites ."
],
"offsets": [
[
0,
186
]
]
}
] | [
{
"id": "split_0_train_48514_entity",
"type": "progene_text",
"text": [
"APOE"
],
"offsets": [
[
56,
60
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30022 | split_0_train_30022 | [
{
"id": "split_0_train_30022_passage",
"type": "progene_text",
"text": [
"The frequency distribution of the overall APOH alleles of the Buryat was similar to that of the Japanese in Asia ."
],
"offsets": [
[
0,
114
]
]
}
] | [
{
"id": "split_0_train_48515_entity",
"type": "progene_text",
"text": [
"APOH"
],
"offsets": [
[
42,
46
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30023 | split_0_train_30023 | [
{
"id": "split_0_train_30023_passage",
"type": "progene_text",
"text": [
"Overall plasma lipid levels of the Buryat ( males aged 20 to 73 years , females aged 21 to 64 years ) were considerably lower , comparable to those of the Evenki ."
],
"offsets": [
[
0,
163
]
]
}
] | [] | [] | [] | [] |
split_0_train_30024 | split_0_train_30024 | [
{
"id": "split_0_train_30024_passage",
"type": "progene_text",
"text": [
"The APOE*4 / E*3 males had significantly high total - and LDL - cholesterol levels compared with the APOE*3 / E*3 males ( p < 0.025 and p < 0.01 , respectively ) ."
],
"offsets": [
[
0,
163
]
]
}
] | [
{
"id": "split_0_train_48516_entity",
"type": "progene_text",
"text": [
"APOE*4 / E*3"
],
"offsets": [
[
4,
16
]
],
"normalized": []
},
{
"id": "split_0_train_48517_entity",
"type": "progene_text",
"text": [
"LDL"
],
"offsets": [
[
58,
61
]
],
"normalized": []
},
{
"id": "split_0_train_48518_entity",
"type": "progene_text",
"text": [
"APOE*3 / E*3"
],
"offsets": [
[
101,
113
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30025 | split_0_train_30025 | [
{
"id": "split_0_train_30025_passage",
"type": "progene_text",
"text": [
"No significant effects of the APOH genotypes on any of the plasma lipid levels were observed ."
],
"offsets": [
[
0,
94
]
]
}
] | [
{
"id": "split_0_train_48519_entity",
"type": "progene_text",
"text": [
"APOH"
],
"offsets": [
[
30,
34
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30026 | split_0_train_30026 | [
{
"id": "split_0_train_30026_passage",
"type": "progene_text",
"text": [
"In particular , our data regarding APOE suggest that the Buryat are genetically close in allele frequencies to the Evenki and Inuits , but differ from them in the association of genotype APOE*4 / E*3 with cholesterol levels ."
],
"offsets": [
[
0,
225
]
]
}
] | [
{
"id": "split_0_train_48520_entity",
"type": "progene_text",
"text": [
"APOE"
],
"offsets": [
[
35,
39
]
],
"normalized": []
},
{
"id": "split_0_train_48521_entity",
"type": "progene_text",
"text": [
"APOE*4 / E*3"
],
"offsets": [
[
187,
199
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30027 | split_0_train_30027 | [
{
"id": "split_0_train_30027_passage",
"type": "progene_text",
"text": [
"BCR / ABL alters the function of NK cells and the acquisition of killer immunoglobulin - like receptors ( KIRs ) ."
],
"offsets": [
[
0,
114
]
]
}
] | [
{
"id": "split_0_train_48522_entity",
"type": "progene_text",
"text": [
"BCR"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_48523_entity",
"type": "progene_text",
"text": [
"ABL"
],
"offsets": [
[
6,
9
]
],
"normalized": []
},
{
"id": "split_0_train_48524_entity",
"type": "progene_text",
"text": [
"killer immunoglobulin - like receptors"
],
"offsets": [
[
65,
103
]
],
"normalized": []
},
{
"id": "split_0_train_48525_entity",
"type": "progene_text",
"text": [
"KIRs"
],
"offsets": [
[
106,
110
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30028 | split_0_train_30028 | [
{
"id": "split_0_train_30028_passage",
"type": "progene_text",
"text": [
"Natural killer ( NK ) cells decrease in function during chronic myelogenous leukemia ( CML ) progression from chronic phase to blast crisis , and they can become BCR / ABL ( + ) late in the disease course ."
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0,
206
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] | [
{
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162,
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{
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"type": "progene_text",
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"ABL"
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168,
171
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],
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}
] | [] | [] | [] |
split_0_train_30029 | split_0_train_30029 | [
{
"id": "split_0_train_30029_passage",
"type": "progene_text",
"text": [
"To study this altered function , NK92 cells were transduced with the BCR / ABL oncogene ."
],
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[
0,
89
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}
] | [
{
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"ABL"
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75,
78
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],
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}
] | [] | [] | [] |
split_0_train_30030 | split_0_train_30030 | [
{
"id": "split_0_train_30030_passage",
"type": "progene_text",
"text": [
"In contrast to the parental cells , which died when deprived of interleukin 2 ( IL-2 ) , p210 ( + ) NK92 cells proliferated and survived indefinitely in the absence of IL-2 ."
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[
0,
174
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] | [
{
"id": "split_0_train_48530_entity",
"type": "progene_text",
"text": [
"interleukin 2"
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64,
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{
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"type": "progene_text",
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80,
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{
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"type": "progene_text",
"text": [
"IL-2"
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168,
172
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],
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}
] | [] | [] | [] |
split_0_train_30031 | split_0_train_30031 | [
{
"id": "split_0_train_30031_passage",
"type": "progene_text",
"text": [
"BCR / ABL also decreased the natural cytotoxicity of NK92 cells against K562 targets , without affecting IL-2 , interferon gamma ( IFN-gamma ) , or tumor necrosis factor alpha ( TNF-alpha ) production ."
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[
0,
202
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}
] | [
{
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{
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105,
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{
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112,
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{
"id": "split_0_train_48537_entity",
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131,
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{
"id": "split_0_train_48538_entity",
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148,
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{
"id": "split_0_train_48539_entity",
"type": "progene_text",
"text": [
"TNF-alpha"
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178,
187
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30032 | split_0_train_30032 | [
{
"id": "split_0_train_30032_passage",
"type": "progene_text",
"text": [
"Although the ABL - specific tyrosine kinase inhibitor imatinib mesylate ( STI-571 ) had no effect on parental NK92 cells , it markedly decreased the growth and survival of IL-2 - independent p210 ( + ) NK92 cells ."
],
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[
0,
214
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]
}
] | [
{
"id": "split_0_train_48540_entity",
"type": "progene_text",
"text": [
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13,
16
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{
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"type": "progene_text",
"text": [
"tyrosine kinase"
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28,
43
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{
"id": "split_0_train_48542_entity",
"type": "progene_text",
"text": [
"IL-2"
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[
172,
176
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],
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}
] | [] | [] | [] |
split_0_train_30033 | split_0_train_30033 | [
{
"id": "split_0_train_30033_passage",
"type": "progene_text",
"text": [
"In contrast to the parental cell line , serial analysis of p210 ( + ) NK92 cells detected small populations that clonally expressed one or more killer immunoglobulin - like receptors ( KIRs ) ."
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[
0,
193
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]
}
] | [
{
"id": "split_0_train_48543_entity",
"type": "progene_text",
"text": [
"killer immunoglobulin - like receptors"
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144,
182
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{
"id": "split_0_train_48544_entity",
"type": "progene_text",
"text": [
"KIRs"
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[
185,
189
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30034 | split_0_train_30034 | [
{
"id": "split_0_train_30034_passage",
"type": "progene_text",
"text": [
"Unlike the decreased natural cytotoxicity , the function of the activating CD158j receptor remained intact ."
],
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[
0,
108
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]
}
] | [
{
"id": "split_0_train_48545_entity",
"type": "progene_text",
"text": [
"CD158j"
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[
75,
81
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30035 | split_0_train_30035 | [
{
"id": "split_0_train_30035_passage",
"type": "progene_text",
"text": [
"Southern blotting and hybridization with an enhanced green fluorescence protein ( eGFP ) probe showed that KIR (-) and KIR ( + ) NK92 cells were all derived from the same clone , suggesting that KIR acquisition remains dynamic at the maturational stage represented by the NK92 cell line ."
],
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[
0,
288
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]
}
] | [
{
"id": "split_0_train_48546_entity",
"type": "progene_text",
"text": [
"green fluorescence protein"
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53,
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{
"id": "split_0_train_48547_entity",
"type": "progene_text",
"text": [
"eGFP"
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82,
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{
"id": "split_0_train_48548_entity",
"type": "progene_text",
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"KIR"
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107,
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{
"id": "split_0_train_48549_entity",
"type": "progene_text",
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"KIR"
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119,
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{
"id": "split_0_train_48550_entity",
"type": "progene_text",
"text": [
"KIR"
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[
195,
198
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30036 | split_0_train_30036 | [
{
"id": "split_0_train_30036_passage",
"type": "progene_text",
"text": [
"When tested in primary CD56 (+bright) NK cells , p210 induced partial IL-2 - independent growth and increased KIR expression similar to findings in NK92 cells ."
],
"offsets": [
[
0,
160
]
]
}
] | [
{
"id": "split_0_train_48551_entity",
"type": "progene_text",
"text": [
"CD56"
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23,
27
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],
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},
{
"id": "split_0_train_48552_entity",
"type": "progene_text",
"text": [
"IL-2"
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70,
74
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],
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},
{
"id": "split_0_train_48553_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
110,
113
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30037 | split_0_train_30037 | [
{
"id": "split_0_train_30037_passage",
"type": "progene_text",
"text": [
"This is the first study to show that BCR / ABL , well known for its effects on the myeloid lineage , can alter the function of lymphoid cells , which may be associated with the defect in innate immunity associated with CML progression ."
],
"offsets": [
[
0,
236
]
]
}
] | [
{
"id": "split_0_train_48554_entity",
"type": "progene_text",
"text": [
"BCR"
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37,
40
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},
{
"id": "split_0_train_48555_entity",
"type": "progene_text",
"text": [
"ABL"
],
"offsets": [
[
43,
46
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30038 | split_0_train_30038 | [
{
"id": "split_0_train_30038_passage",
"type": "progene_text",
"text": [
"Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1 ."
],
"offsets": [
[
0,
94
]
]
}
] | [
{
"id": "split_0_train_48556_entity",
"type": "progene_text",
"text": [
"Sam68"
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0,
5
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},
{
"id": "split_0_train_48557_entity",
"type": "progene_text",
"text": [
"arginine N-methyltransferase 1"
],
"offsets": [
[
62,
92
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30039 | split_0_train_30039 | [
{
"id": "split_0_train_30039_passage",
"type": "progene_text",
"text": [
"RNA binding proteins often contain multiple arginine glycine repeats , a sequence that is frequently methylated by protein arginine methyltransferases ."
],
"offsets": [
[
0,
152
]
]
}
] | [
{
"id": "split_0_train_48558_entity",
"type": "progene_text",
"text": [
"protein arginine methyltransferases"
],
"offsets": [
[
115,
150
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30040 | split_0_train_30040 | [
{
"id": "split_0_train_30040_passage",
"type": "progene_text",
"text": [
"The role of this posttranslational modification in the life cycle of RNA binding proteins is not well understood ."
],
"offsets": [
[
0,
114
]
]
}
] | [] | [] | [] | [] |
split_0_train_30041 | split_0_train_30041 | [
{
"id": "split_0_train_30041_passage",
"type": "progene_text",
"text": [
"Herein , we report that Sam68 , a heteronuclear ribonucleoprotein K homology domain containing RNA binding protein , associates with and is methylated in vivo by the protein arginine N-methyltransferase 1 ( PRMT1 ) ."
],
"offsets": [
[
0,
216
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]
}
] | [
{
"id": "split_0_train_48559_entity",
"type": "progene_text",
"text": [
"Sam68"
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24,
29
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},
{
"id": "split_0_train_48560_entity",
"type": "progene_text",
"text": [
"protein arginine N-methyltransferase 1"
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166,
204
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{
"id": "split_0_train_48561_entity",
"type": "progene_text",
"text": [
"PRMT1"
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207,
212
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30042 | split_0_train_30042 | [
{
"id": "split_0_train_30042_passage",
"type": "progene_text",
"text": [
"Sam68 contains asymmetrical dimethylarginines near its proline motif P3 as assessed by using a novel asymmetrical dimethylarginine - specific antibody and mass spectrometry ."
],
"offsets": [
[
0,
174
]
]
}
] | [
{
"id": "split_0_train_48562_entity",
"type": "progene_text",
"text": [
"Sam68"
],
"offsets": [
[
0,
5
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30043 | split_0_train_30043 | [
{
"id": "split_0_train_30043_passage",
"type": "progene_text",
"text": [
"Deletion of the methylation sites and the use of methylase inhibitors resulted in Sam68 accumulation in the cytoplasm ."
],
"offsets": [
[
0,
119
]
]
}
] | [
{
"id": "split_0_train_48563_entity",
"type": "progene_text",
"text": [
"methylase"
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49,
58
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},
{
"id": "split_0_train_48564_entity",
"type": "progene_text",
"text": [
"Sam68"
],
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[
82,
87
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30044 | split_0_train_30044 | [
{
"id": "split_0_train_30044_passage",
"type": "progene_text",
"text": [
"Sam68 was also detected in the cytoplasm of PRMT1 - deficient embryonic stem cells ."
],
"offsets": [
[
0,
84
]
]
}
] | [
{
"id": "split_0_train_48565_entity",
"type": "progene_text",
"text": [
"Sam68"
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[
0,
5
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},
{
"id": "split_0_train_48566_entity",
"type": "progene_text",
"text": [
"PRMT1"
],
"offsets": [
[
44,
49
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30045 | split_0_train_30045 | [
{
"id": "split_0_train_30045_passage",
"type": "progene_text",
"text": [
"Although the cellular function of Sam68 is unknown , it has been shown to export unspliced human immunodeficiency virus RNAs ."
],
"offsets": [
[
0,
126
]
]
}
] | [
{
"id": "split_0_train_48567_entity",
"type": "progene_text",
"text": [
"Sam68"
],
"offsets": [
[
34,
39
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30046 | split_0_train_30046 | [
{
"id": "split_0_train_30046_passage",
"type": "progene_text",
"text": [
"Cells treated with methylase inhibitors prevented the ability of Sam68 to export unspliced human immunodeficiency virus RNAs ."
],
"offsets": [
[
0,
126
]
]
}
] | [
{
"id": "split_0_train_48568_entity",
"type": "progene_text",
"text": [
"methylase"
],
"offsets": [
[
19,
28
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],
"normalized": []
},
{
"id": "split_0_train_48569_entity",
"type": "progene_text",
"text": [
"Sam68"
],
"offsets": [
[
65,
70
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30047 | split_0_train_30047 | [
{
"id": "split_0_train_30047_passage",
"type": "progene_text",
"text": [
"Other K homology domain RNA binding proteins , including SLM-1 , SLM-2 , QKI-5 , GRP33 , and heteronuclear ribonucleoprotein K were also methylated in vivo ."
],
"offsets": [
[
0,
157
]
]
}
] | [
{
"id": "split_0_train_48570_entity",
"type": "progene_text",
"text": [
"SLM-1"
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57,
62
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],
"normalized": []
},
{
"id": "split_0_train_48571_entity",
"type": "progene_text",
"text": [
"SLM-2"
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[
65,
70
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],
"normalized": []
},
{
"id": "split_0_train_48572_entity",
"type": "progene_text",
"text": [
"QKI-5"
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[
73,
78
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],
"normalized": []
},
{
"id": "split_0_train_48573_entity",
"type": "progene_text",
"text": [
"GRP33"
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[
81,
86
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],
"normalized": []
},
{
"id": "split_0_train_48574_entity",
"type": "progene_text",
"text": [
"heteronuclear ribonucleoprotein K"
],
"offsets": [
[
93,
126
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30048 | split_0_train_30048 | [
{
"id": "split_0_train_30048_passage",
"type": "progene_text",
"text": [
"These findings demonstrate that RNA binding proteins are in vivo substrates for PRMT1 , and their methylation is essential for their proper localization and function ."
],
"offsets": [
[
0,
167
]
]
}
] | [
{
"id": "split_0_train_48575_entity",
"type": "progene_text",
"text": [
"PRMT1"
],
"offsets": [
[
80,
85
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30049 | split_0_train_30049 | [
{
"id": "split_0_train_30049_passage",
"type": "progene_text",
"text": [
"Specific stimulation of human apurinic / apyrimidinic endonuclease by heat shock protein 70 ."
],
"offsets": [
[
0,
93
]
]
}
] | [
{
"id": "split_0_train_48576_entity",
"type": "progene_text",
"text": [
"apurinic / apyrimidinic endonuclease"
],
"offsets": [
[
30,
66
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],
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},
{
"id": "split_0_train_48577_entity",
"type": "progene_text",
"text": [
"heat shock protein 70"
],
"offsets": [
[
70,
91
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30050 | split_0_train_30050 | [
{
"id": "split_0_train_30050_passage",
"type": "progene_text",
"text": [
"We previously demonstrated the stimulation of human apurinic / apyrimidinic endonuclease 1 ( HAP1 ) by heat shock protein 70 ( HSP70 ) ."
],
"offsets": [
[
0,
136
]
]
}
] | [
{
"id": "split_0_train_48578_entity",
"type": "progene_text",
"text": [
"apurinic / apyrimidinic endonuclease 1"
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"offsets": [
[
52,
90
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],
"normalized": []
},
{
"id": "split_0_train_48579_entity",
"type": "progene_text",
"text": [
"HAP1"
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"offsets": [
[
93,
97
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],
"normalized": []
},
{
"id": "split_0_train_48580_entity",
"type": "progene_text",
"text": [
"heat shock protein 70"
],
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[
103,
124
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],
"normalized": []
},
{
"id": "split_0_train_48581_entity",
"type": "progene_text",
"text": [
"HSP70"
],
"offsets": [
[
127,
132
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30051 | split_0_train_30051 | [
{
"id": "split_0_train_30051_passage",
"type": "progene_text",
"text": [
"In this work , we further defined the functional interaction between these proteins ."
],
"offsets": [
[
0,
85
]
]
}
] | [] | [] | [] | [] |
split_0_train_30052 | split_0_train_30052 | [
{
"id": "split_0_train_30052_passage",
"type": "progene_text",
"text": [
"Digestion of HSP70 by trypsin released 48 and 43 kDa amino terminal fragments that retained the ability to stimulate HAP1 ."
],
"offsets": [
[
0,
123
]
]
}
] | [
{
"id": "split_0_train_48582_entity",
"type": "progene_text",
"text": [
"HSP70"
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[
13,
18
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],
"normalized": []
},
{
"id": "split_0_train_48583_entity",
"type": "progene_text",
"text": [
"trypsin"
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[
22,
29
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"normalized": []
},
{
"id": "split_0_train_48584_entity",
"type": "progene_text",
"text": [
"HAP1"
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117,
121
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"normalized": []
}
] | [] | [] | [] |
split_0_train_30053 | split_0_train_30053 | [
{
"id": "split_0_train_30053_passage",
"type": "progene_text",
"text": [
"In agreement with this result , an HSP70 N - terminal deletion mutant protein containing amino acids 1 - 385 was comparable to the full - length protein in its ability to enhance HAP1 activity ."
],
"offsets": [
[
0,
194
]
]
}
] | [
{
"id": "split_0_train_48585_entity",
"type": "progene_text",
"text": [
"HSP70"
],
"offsets": [
[
35,
40
]
],
"normalized": []
},
{
"id": "split_0_train_48586_entity",
"type": "progene_text",
"text": [
"HAP1"
],
"offsets": [
[
179,
183
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30054 | split_0_train_30054 | [
{
"id": "split_0_train_30054_passage",
"type": "progene_text",
"text": [
"HSP70 mutants containing carboxy terminal amino acids 386 - 640 stimulated HAP1 only slightly , as did unrelated proteins ."
],
"offsets": [
[
0,
123
]
]
}
] | [
{
"id": "split_0_train_48587_entity",
"type": "progene_text",
"text": [
"HSP70"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_48588_entity",
"type": "progene_text",
"text": [
"HAP1"
],
"offsets": [
[
75,
79
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30055 | split_0_train_30055 | [
{
"id": "split_0_train_30055_passage",
"type": "progene_text",
"text": [
"These results implicate the amino terminal portion of HSP70 in stimulating the activity of HAP1 ."
],
"offsets": [
[
0,
97
]
]
}
] | [
{
"id": "split_0_train_48589_entity",
"type": "progene_text",
"text": [
"HSP70"
],
"offsets": [
[
54,
59
]
],
"normalized": []
},
{
"id": "split_0_train_48590_entity",
"type": "progene_text",
"text": [
"HAP1"
],
"offsets": [
[
91,
95
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30056 | split_0_train_30056 | [
{
"id": "split_0_train_30056_passage",
"type": "progene_text",
"text": [
"Synergism between nuclear receptors bound to specific hormone response elements of the hepatic control region-1 and the proximal apolipoprotein C-II promoter mediate apolipoprotein C-II gene regulation by bile acids and retinoids ."
],
"offsets": [
[
0,
231
]
]
}
] | [
{
"id": "split_0_train_48591_entity",
"type": "progene_text",
"text": [
"nuclear receptors"
],
"offsets": [
[
18,
35
]
],
"normalized": []
},
{
"id": "split_0_train_48592_entity",
"type": "progene_text",
"text": [
"apolipoprotein C-II"
],
"offsets": [
[
129,
148
]
],
"normalized": []
},
{
"id": "split_0_train_48593_entity",
"type": "progene_text",
"text": [
"apolipoprotein C-II"
],
"offsets": [
[
166,
185
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30057 | split_0_train_30057 | [
{
"id": "split_0_train_30057_passage",
"type": "progene_text",
"text": [
"We have shown previously that the hepatic control region 1 ( HCR-1 ) enhances the activity of the human apolipoprotein C-II ( apoC-II ) promoter in HepG2 cells via two hormone response elements ( HREs ) present in the apoC-II promoter ."
],
"offsets": [
[
0,
236
]
]
}
] | [
{
"id": "split_0_train_48594_entity",
"type": "progene_text",
"text": [
"apolipoprotein C-II"
],
"offsets": [
[
104,
123
]
],
"normalized": []
},
{
"id": "split_0_train_48595_entity",
"type": "progene_text",
"text": [
"apoC-II"
],
"offsets": [
[
126,
133
]
],
"normalized": []
},
{
"id": "split_0_train_48596_entity",
"type": "progene_text",
"text": [
"apoC-II"
],
"offsets": [
[
218,
225
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30058 | split_0_train_30058 | [
{
"id": "split_0_train_30058_passage",
"type": "progene_text",
"text": [
"In the present paper , we report that the HCR-1 selectively mediates the transactivation of the apoC-II promoter by chenodeoxycholic acid ( CDCA ) and 9 - cis - retinoic acid ."
],
"offsets": [
[
0,
176
]
]
}
] | [
{
"id": "split_0_train_48597_entity",
"type": "progene_text",
"text": [
"apoC-II"
],
"offsets": [
[
96,
103
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30059 | split_0_train_30059 | [
{
"id": "split_0_train_30059_passage",
"type": "progene_text",
"text": [
"CDCA , which is a natural ligand of farnesoid X receptor alpha ( FXRalpha ) , increases the steady - state apoC-II mRNA levels in HepG2 cells ."
],
"offsets": [
[
0,
143
]
]
}
] | [
{
"id": "split_0_train_48598_entity",
"type": "progene_text",
"text": [
"farnesoid X receptor alpha"
],
"offsets": [
[
36,
62
]
],
"normalized": []
},
{
"id": "split_0_train_48599_entity",
"type": "progene_text",
"text": [
"FXRalpha"
],
"offsets": [
[
65,
73
]
],
"normalized": []
},
{
"id": "split_0_train_48600_entity",
"type": "progene_text",
"text": [
"apoC-II"
],
"offsets": [
[
107,
114
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30060 | split_0_train_30060 | [
{
"id": "split_0_train_30060_passage",
"type": "progene_text",
"text": [
"This increase in transcription requires the binding of retinoid X receptor alpha ( RXRalpha ) - FXRalpha heterodimers to a novel inverted repeat with one nucleotide spacing ( IR-1 ) present in the HCR-1 ."
],
"offsets": [
[
0,
204
]
]
}
] | [
{
"id": "split_0_train_48601_entity",
"type": "progene_text",
"text": [
"retinoid X receptor alpha"
],
"offsets": [
[
55,
80
]
],
"normalized": []
},
{
"id": "split_0_train_48602_entity",
"type": "progene_text",
"text": [
"RXRalpha"
],
"offsets": [
[
83,
91
]
],
"normalized": []
},
{
"id": "split_0_train_48603_entity",
"type": "progene_text",
"text": [
"FXRalpha"
],
"offsets": [
[
96,
104
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30061 | split_0_train_30061 | [
{
"id": "split_0_train_30061_passage",
"type": "progene_text",
"text": [
"This element also binds hepatocyte nuclear factor 4 and apoA-I regulatory protein-1 ."
],
"offsets": [
[
0,
85
]
]
}
] | [
{
"id": "split_0_train_48604_entity",
"type": "progene_text",
"text": [
"hepatocyte nuclear factor 4"
],
"offsets": [
[
24,
51
]
],
"normalized": []
},
{
"id": "split_0_train_48605_entity",
"type": "progene_text",
"text": [
"apoA-I regulatory protein-1"
],
"offsets": [
[
56,
83
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30062 | split_0_train_30062 | [
{
"id": "split_0_train_30062_passage",
"type": "progene_text",
"text": [
"Transactivation of the HCR-1 / apoC-II promoter cluster by RXRalpha - FXRalpha heterodimers in the presence of CDCA was abolished by mutations either in the IR-1 HRE of the HCR-1 or in the thyroid HRE of the proximal apoC-II promoter , which binds RXRalpha - thyroid hormone receptor beta ( T3Rbeta ) heterodimers ."
],
"offsets": [
[
0,
315
]
]
}
] | [
{
"id": "split_0_train_48606_entity",
"type": "progene_text",
"text": [
"apoC-II"
],
"offsets": [
[
31,
38
]
],
"normalized": []
},
{
"id": "split_0_train_48607_entity",
"type": "progene_text",
"text": [
"RXRalpha"
],
"offsets": [
[
59,
67
]
],
"normalized": []
},
{
"id": "split_0_train_48608_entity",
"type": "progene_text",
"text": [
"FXRalpha"
],
"offsets": [
[
70,
78
]
],
"normalized": []
},
{
"id": "split_0_train_48609_entity",
"type": "progene_text",
"text": [
"apoC-II"
],
"offsets": [
[
217,
224
]
],
"normalized": []
},
{
"id": "split_0_train_48610_entity",
"type": "progene_text",
"text": [
"RXRalpha"
],
"offsets": [
[
248,
256
]
],
"normalized": []
},
{
"id": "split_0_train_48611_entity",
"type": "progene_text",
"text": [
"thyroid hormone receptor beta"
],
"offsets": [
[
259,
288
]
],
"normalized": []
},
{
"id": "split_0_train_48612_entity",
"type": "progene_text",
"text": [
"T3Rbeta"
],
"offsets": [
[
291,
298
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30063 | split_0_train_30063 | [
{
"id": "split_0_train_30063_passage",
"type": "progene_text",
"text": [
"The same mutations also abolished transactivation of the HCR-1 / apoC-II promoter cluster by RXRalpha - T3Rbeta heterodimers in the presence of tri - iodothyronine ."
],
"offsets": [
[
0,
165
]
]
}
] | [
{
"id": "split_0_train_48613_entity",
"type": "progene_text",
"text": [
"apoC-II"
],
"offsets": [
[
65,
72
]
],
"normalized": []
},
{
"id": "split_0_train_48614_entity",
"type": "progene_text",
"text": [
"RXRalpha"
],
"offsets": [
[
93,
101
]
],
"normalized": []
},
{
"id": "split_0_train_48615_entity",
"type": "progene_text",
"text": [
"T3Rbeta"
],
"offsets": [
[
104,
111
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30064 | split_0_train_30064 | [
{
"id": "split_0_train_30064_passage",
"type": "progene_text",
"text": [
"The findings establish synergism between nuclear receptors bound to specific HREs of the proximal apoC-II promoter and the HCR-1 , and suggest that this synergism mediates the induction of the HCR-1 / apoC-II promoter cluster by bile acids and retinoids ."
],
"offsets": [
[
0,
255
]
]
}
] | [
{
"id": "split_0_train_48616_entity",
"type": "progene_text",
"text": [
"nuclear receptors"
],
"offsets": [
[
41,
58
]
],
"normalized": []
},
{
"id": "split_0_train_48617_entity",
"type": "progene_text",
"text": [
"apoC-II"
],
"offsets": [
[
98,
105
]
],
"normalized": []
},
{
"id": "split_0_train_48618_entity",
"type": "progene_text",
"text": [
"apoC-II"
],
"offsets": [
[
201,
208
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30065 | split_0_train_30065 | [
{
"id": "split_0_train_30065_passage",
"type": "progene_text",
"text": [
"Molecular weight forms of inhibin a and inhibin B in the bovine testis change with age ."
],
"offsets": [
[
0,
88
]
]
}
] | [
{
"id": "split_0_train_48619_entity",
"type": "progene_text",
"text": [
"inhibin a"
],
"offsets": [
[
26,
35
]
],
"normalized": []
},
{
"id": "split_0_train_48620_entity",
"type": "progene_text",
"text": [
"inhibin B"
],
"offsets": [
[
40,
49
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30066 | split_0_train_30066 | [
{
"id": "split_0_train_30066_passage",
"type": "progene_text",
"text": [
"To investigate alterations in the molecular weight forms of inhibin in bull testis from the infantile ( 4-5 wk of age ) to postpubertal ( 49 - 56 wk of age ) periods , testicular homogenates were obtained from animals of various ages and fractionated by a combination of immunoaffinity chromatography and SDS-PAGE ."
],
"offsets": [
[
0,
315
]
]
}
] | [
{
"id": "split_0_train_48621_entity",
"type": "progene_text",
"text": [
"inhibin"
],
"offsets": [
[
60,
67
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30067 | split_0_train_30067 | [
{
"id": "split_0_train_30067_passage",
"type": "progene_text",
"text": [
"Subsequently , the fractions eluted from the SDS gels were assayed for total inhibin , inhibin A , and inhibin B by fluoroimmunoassay or immunofluorometric assays ( IFMAs ) and for inhibin bioactivity by an in vitro bioassay ."
],
"offsets": [
[
0,
226
]
]
}
] | [
{
"id": "split_0_train_48622_entity",
"type": "progene_text",
"text": [
"inhibin"
],
"offsets": [
[
77,
84
]
],
"normalized": []
},
{
"id": "split_0_train_48623_entity",
"type": "progene_text",
"text": [
"inhibin A"
],
"offsets": [
[
87,
96
]
],
"normalized": []
},
{
"id": "split_0_train_48624_entity",
"type": "progene_text",
"text": [
"inhibin B"
],
"offsets": [
[
103,
112
]
],
"normalized": []
},
{
"id": "split_0_train_48625_entity",
"type": "progene_text",
"text": [
"inhibin"
],
"offsets": [
[
181,
188
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30068 | split_0_train_30068 | [
{
"id": "split_0_train_30068_passage",
"type": "progene_text",
"text": [
"The molecular mass patterns of inhibin A and inhibin B in the testis , as determined by the dimer - specific IFMAs , showed the presence of a peak of approximate 47 kDa until 21-26 wk of age ."
],
"offsets": [
[
0,
192
]
]
}
] | [
{
"id": "split_0_train_48626_entity",
"type": "progene_text",
"text": [
"inhibin A"
],
"offsets": [
[
31,
40
]
],
"normalized": []
},
{
"id": "split_0_train_48627_entity",
"type": "progene_text",
"text": [
"inhibin B"
],
"offsets": [
[
45,
54
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30069 | split_0_train_30069 | [
{
"id": "split_0_train_30069_passage",
"type": "progene_text",
"text": [
"However , the peak disappeared after 31 - 32 wk of age ."
],
"offsets": [
[
0,
56
]
]
}
] | [] | [] | [] | [] |
split_0_train_30070 | split_0_train_30070 | [
{
"id": "split_0_train_30070_passage",
"type": "progene_text",
"text": [
"As bulls aged , especially after 31 - 32 wk of age , inhibin A and inhibin B levels increased in the molecular mass region of 27-34 kDa ."
],
"offsets": [
[
0,
137
]
]
}
] | [
{
"id": "split_0_train_48628_entity",
"type": "progene_text",
"text": [
"inhibin A"
],
"offsets": [
[
53,
62
]
],
"normalized": []
},
{
"id": "split_0_train_48629_entity",
"type": "progene_text",
"text": [
"inhibin B"
],
"offsets": [
[
67,
76
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30071 | split_0_train_30071 | [
{
"id": "split_0_train_30071_passage",
"type": "progene_text",
"text": [
"Total inhibin showed two peaks , of between 20 and 26 kDa and at approximately 47 kDa , until 21 - 26 wk of age and a single peak between 20 and 30 kDa after 31-32 wk of age ."
],
"offsets": [
[
0,
175
]
]
}
] | [
{
"id": "split_0_train_48630_entity",
"type": "progene_text",
"text": [
"inhibin"
],
"offsets": [
[
6,
13
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30072 | split_0_train_30072 | [
{
"id": "split_0_train_30072_passage",
"type": "progene_text",
"text": [
"The eluted fractions corresponding to 29 , 31 , or 47 kDa gave a dose - response curve that was parallel to the curve generated with 32 - kDa inhibin A or 29 - kDa inhibin B standard in the IFMA for inhibin A or inhibin B ."
],
"offsets": [
[
0,
223
]
]
}
] | [
{
"id": "split_0_train_48631_entity",
"type": "progene_text",
"text": [
"inhibin A"
],
"offsets": [
[
142,
151
]
],
"normalized": []
},
{
"id": "split_0_train_48632_entity",
"type": "progene_text",
"text": [
"inhibin B"
],
"offsets": [
[
164,
173
]
],
"normalized": []
},
{
"id": "split_0_train_48633_entity",
"type": "progene_text",
"text": [
"inhibin A"
],
"offsets": [
[
199,
208
]
],
"normalized": []
},
{
"id": "split_0_train_48634_entity",
"type": "progene_text",
"text": [
"inhibin B"
],
"offsets": [
[
212,
221
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30073 | split_0_train_30073 | [
{
"id": "split_0_train_30073_passage",
"type": "progene_text",
"text": [
"The fractions corresponding to 29 and 31 kDa suppressed basal release of FSH from rat pituitary cells , but the 47 - kDa fraction had a lower FSH - suppressing activity ."
],
"offsets": [
[
0,
170
]
]
}
] | [
{
"id": "split_0_train_48635_entity",
"type": "progene_text",
"text": [
"FSH"
],
"offsets": [
[
73,
76
]
],
"normalized": []
},
{
"id": "split_0_train_48636_entity",
"type": "progene_text",
"text": [
"FSH"
],
"offsets": [
[
142,
145
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30074 | split_0_train_30074 | [
{
"id": "split_0_train_30074_passage",
"type": "progene_text",
"text": [
"In the testes of older bulls , immunoblot analysis revealed the presence of a 29 - kDa band cross - reacting with inhibin alpha and inhibin betaB antibodies and of a 31 - kDa band cross - reacting with inhibin alpha and inhibin betaA antibodies ."
],
"offsets": [
[
0,
246
]
]
}
] | [
{
"id": "split_0_train_48637_entity",
"type": "progene_text",
"text": [
"inhibin alpha"
],
"offsets": [
[
114,
127
]
],
"normalized": []
},
{
"id": "split_0_train_48638_entity",
"type": "progene_text",
"text": [
"inhibin betaB"
],
"offsets": [
[
132,
145
]
],
"normalized": []
},
{
"id": "split_0_train_48639_entity",
"type": "progene_text",
"text": [
"inhibin alpha"
],
"offsets": [
[
202,
215
]
],
"normalized": []
},
{
"id": "split_0_train_48640_entity",
"type": "progene_text",
"text": [
"inhibin betaA"
],
"offsets": [
[
220,
233
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30075 | split_0_train_30075 | [
{
"id": "split_0_train_30075_passage",
"type": "progene_text",
"text": [
"The 47 - kDa band was recognized by the alpha , betaA , and betaB antibodies ."
],
"offsets": [
[
0,
78
]
]
}
] | [] | [] | [] | [] |
split_0_train_30076 | split_0_train_30076 | [
{
"id": "split_0_train_30076_passage",
"type": "progene_text",
"text": [
"Immunohistochemisty of the testis at each age showed that inhibin alpha subunits were found exclusively in Sertoli cells , but the intensity of immunostaining diminished in older bulls , in parallel with the decrease in the testicular concentrations of total inhibin ."
],
"offsets": [
[
0,
268
]
]
}
] | [
{
"id": "split_0_train_48641_entity",
"type": "progene_text",
"text": [
"inhibin alpha"
],
"offsets": [
[
58,
71
]
],
"normalized": []
},
{
"id": "split_0_train_48642_entity",
"type": "progene_text",
"text": [
"inhibin"
],
"offsets": [
[
259,
266
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30077 | split_0_train_30077 | [
{
"id": "split_0_train_30077_passage",
"type": "progene_text",
"text": [
"We conclude that 1 ) bovine Sertoli cells produce both inhibin A and inhibin B , 2 ) inhibin production in Sertoli cells during the prepubertal period is characterized by the 47 kDa inhibin - related material that contains precursor forms of inhibin A and inhibin B , and 3 ) the proportion of the mature forms of inhibin A and inhibin B increases as bulls age , although total inhibin production in Setroli cells decreases ."
],
"offsets": [
[
0,
425
]
]
}
] | [
{
"id": "split_0_train_48643_entity",
"type": "progene_text",
"text": [
"inhibin A"
],
"offsets": [
[
55,
64
]
],
"normalized": []
},
{
"id": "split_0_train_48644_entity",
"type": "progene_text",
"text": [
"inhibin B"
],
"offsets": [
[
69,
78
]
],
"normalized": []
},
{
"id": "split_0_train_48645_entity",
"type": "progene_text",
"text": [
"inhibin"
],
"offsets": [
[
85,
92
]
],
"normalized": []
},
{
"id": "split_0_train_48646_entity",
"type": "progene_text",
"text": [
"inhibin"
],
"offsets": [
[
182,
189
]
],
"normalized": []
},
{
"id": "split_0_train_48647_entity",
"type": "progene_text",
"text": [
"inhibin A"
],
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[
242,
251
]
],
"normalized": []
},
{
"id": "split_0_train_48648_entity",
"type": "progene_text",
"text": [
"inhibin B"
],
"offsets": [
[
256,
265
]
],
"normalized": []
},
{
"id": "split_0_train_48649_entity",
"type": "progene_text",
"text": [
"inhibin A"
],
"offsets": [
[
314,
323
]
],
"normalized": []
},
{
"id": "split_0_train_48650_entity",
"type": "progene_text",
"text": [
"inhibin B"
],
"offsets": [
[
328,
337
]
],
"normalized": []
},
{
"id": "split_0_train_48651_entity",
"type": "progene_text",
"text": [
"inhibin"
],
"offsets": [
[
378,
385
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30078 | split_0_train_30078 | [
{
"id": "split_0_train_30078_passage",
"type": "progene_text",
"text": [
"Identification of the mouse killer immunoglobulin - like receptor - like ( Kirl ) gene family mapping to chromosome X ."
],
"offsets": [
[
0,
119
]
]
}
] | [
{
"id": "split_0_train_48652_entity",
"type": "progene_text",
"text": [
"killer immunoglobulin - like receptor - like ( Kirl ) gene family"
],
"offsets": [
[
28,
93
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30079 | split_0_train_30079 | [
{
"id": "split_0_train_30079_passage",
"type": "progene_text",
"text": [
"Natural killer ( NK ) inhibitory receptors , which recognize major histocompatability complex ( MHC ) proteins in humans , are known as killer Ig - like receptors ( KIRs ) and are encoded by a multi - gene immunoglobulin ( Ig ) superfamily ."
],
"offsets": [
[
0,
241
]
]
}
] | [
{
"id": "split_0_train_48653_entity",
"type": "progene_text",
"text": [
"major histocompatability complex"
],
"offsets": [
[
61,
93
]
],
"normalized": []
},
{
"id": "split_0_train_48654_entity",
"type": "progene_text",
"text": [
"MHC"
],
"offsets": [
[
96,
99
]
],
"normalized": []
},
{
"id": "split_0_train_48655_entity",
"type": "progene_text",
"text": [
"killer Ig - like receptors"
],
"offsets": [
[
136,
162
]
],
"normalized": []
},
{
"id": "split_0_train_48656_entity",
"type": "progene_text",
"text": [
"KIRs"
],
"offsets": [
[
165,
169
]
],
"normalized": []
},
{
"id": "split_0_train_48657_entity",
"type": "progene_text",
"text": [
"immunoglobulin ( Ig ) superfamily"
],
"offsets": [
[
206,
239
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30080 | split_0_train_30080 | [
{
"id": "split_0_train_30080_passage",
"type": "progene_text",
"text": [
"In a screen for genes differentially expressed in the mouse thymus , we discovered the first close rodent homologue of the NK receptor KIR family , which we named KIR - Like ( Kirl ) ."
],
"offsets": [
[
0,
184
]
]
}
] | [
{
"id": "split_0_train_48658_entity",
"type": "progene_text",
"text": [
"KIR family"
],
"offsets": [
[
135,
145
]
],
"normalized": []
},
{
"id": "split_0_train_48659_entity",
"type": "progene_text",
"text": [
"KIR - Like"
],
"offsets": [
[
163,
173
]
],
"normalized": []
},
{
"id": "split_0_train_48660_entity",
"type": "progene_text",
"text": [
"Kirl"
],
"offsets": [
[
176,
180
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30081 | split_0_train_30081 | [
{
"id": "split_0_train_30081_passage",
"type": "progene_text",
"text": [
"KIRL1 shares 40 % amino acid identity with primate KIR family members , with the majority of the homology contained within the Ig - like ectodomains ."
],
"offsets": [
[
0,
150
]
]
}
] | [
{
"id": "split_0_train_48661_entity",
"type": "progene_text",
"text": [
"KIRL1"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_48662_entity",
"type": "progene_text",
"text": [
"KIR family"
],
"offsets": [
[
51,
61
]
],
"normalized": []
},
{
"id": "split_0_train_48663_entity",
"type": "progene_text",
"text": [
"Ig"
],
"offsets": [
[
127,
129
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30082 | split_0_train_30082 | [
{
"id": "split_0_train_30082_passage",
"type": "progene_text",
"text": [
"KIRL1 is more similar to the KIRs than to any other known member of the Ig domain - containing leukocyte receptor superfamily ."
],
"offsets": [
[
0,
127
]
]
}
] | [
{
"id": "split_0_train_48664_entity",
"type": "progene_text",
"text": [
"KIRL1"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_48665_entity",
"type": "progene_text",
"text": [
"KIRs"
],
"offsets": [
[
29,
33
]
],
"normalized": []
},
{
"id": "split_0_train_48666_entity",
"type": "progene_text",
"text": [
"Ig domain - containing leukocyte receptor superfamily"
],
"offsets": [
[
72,
125
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30083 | split_0_train_30083 | [
{
"id": "split_0_train_30083_passage",
"type": "progene_text",
"text": [
"This highly significant homology suggests that the KIR family did not arise independently in primates , as has been previously suggested , but rather evolved from a primordial gene already present in the common rodent / primate ancestor ."
],
"offsets": [
[
0,
238
]
]
}
] | [
{
"id": "split_0_train_48667_entity",
"type": "progene_text",
"text": [
"KIR family"
],
"offsets": [
[
51,
61
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30084 | split_0_train_30084 | [
{
"id": "split_0_train_30084_passage",
"type": "progene_text",
"text": [
"KIRL1 lacks the cytoplasmic protein motifs that mediate inhibition in KIRs ( immunoregulatory tyrosine inhibiting motif , ITIM ) ; KIRL1 also lacks the transmembrane activation signature ( a conserved K residue involved in association with the immunoregulatory tyrosine activating motif - containing DAP12 molecule ) found in some KIRs ."
],
"offsets": [
[
0,
337
]
]
}
] | [
{
"id": "split_0_train_48668_entity",
"type": "progene_text",
"text": [
"KIRL1"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_48669_entity",
"type": "progene_text",
"text": [
"KIRs"
],
"offsets": [
[
70,
74
]
],
"normalized": []
},
{
"id": "split_0_train_48670_entity",
"type": "progene_text",
"text": [
"KIRL1"
],
"offsets": [
[
131,
136
]
],
"normalized": []
},
{
"id": "split_0_train_48671_entity",
"type": "progene_text",
"text": [
"DAP12"
],
"offsets": [
[
300,
305
]
],
"normalized": []
},
{
"id": "split_0_train_48672_entity",
"type": "progene_text",
"text": [
"KIRs"
],
"offsets": [
[
331,
335
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30085 | split_0_train_30085 | [
{
"id": "split_0_train_30085_passage",
"type": "progene_text",
"text": [
"Nevertheless , we hypothesize that Kirl1 is functional , for the following reasons : (1) Kirl1 mRNA is expressed at high levels in immature thymocytes ; (2) Kirl1 is regulated during thymocyte development ; (3) KIRL1 protein is detected in thymus ."
],
"offsets": [
[
0,
248
]
]
}
] | [
{
"id": "split_0_train_48673_entity",
"type": "progene_text",
"text": [
"Kirl1"
],
"offsets": [
[
35,
40
]
],
"normalized": []
},
{
"id": "split_0_train_48674_entity",
"type": "progene_text",
"text": [
"Kirl1"
],
"offsets": [
[
89,
94
]
],
"normalized": []
},
{
"id": "split_0_train_48675_entity",
"type": "progene_text",
"text": [
"Kirl1"
],
"offsets": [
[
157,
162
]
],
"normalized": []
},
{
"id": "split_0_train_48676_entity",
"type": "progene_text",
"text": [
"KIRL1"
],
"offsets": [
[
211,
216
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30086 | split_0_train_30086 | [
{
"id": "split_0_train_30086_passage",
"type": "progene_text",
"text": [
"We also show that the mouse genome contains a closely related , transcribed gene , which we name Kirl2 ."
],
"offsets": [
[
0,
104
]
]
}
] | [
{
"id": "split_0_train_48677_entity",
"type": "progene_text",
"text": [
"Kirl2"
],
"offsets": [
[
97,
102
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30087 | split_0_train_30087 | [
{
"id": "split_0_train_30087_passage",
"type": "progene_text",
"text": [
"Kirl2 encodes a KIR - like molecule with three Ig - like domains and also lacks tyrosine - based immunoregulatory motifs in its cytoplasmic region ."
],
"offsets": [
[
0,
148
]
]
}
] | [
{
"id": "split_0_train_48678_entity",
"type": "progene_text",
"text": [
"Kirl2"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_48679_entity",
"type": "progene_text",
"text": [
"KIR - like"
],
"offsets": [
[
16,
26
]
],
"normalized": []
},
{
"id": "split_0_train_48680_entity",
"type": "progene_text",
"text": [
"Ig"
],
"offsets": [
[
47,
49
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30088 | split_0_train_30088 | [
{
"id": "split_0_train_30088_passage",
"type": "progene_text",
"text": [
"ArhGAP15 , a novel human RacGAP protein with GTPase binding property ."
],
"offsets": [
[
0,
70
]
]
}
] | [
{
"id": "split_0_train_48681_entity",
"type": "progene_text",
"text": [
"ArhGAP15"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "split_0_train_48682_entity",
"type": "progene_text",
"text": [
"RacGAP"
],
"offsets": [
[
25,
31
]
],
"normalized": []
},
{
"id": "split_0_train_48683_entity",
"type": "progene_text",
"text": [
"GTPase"
],
"offsets": [
[
45,
51
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30089 | split_0_train_30089 | [
{
"id": "split_0_train_30089_passage",
"type": "progene_text",
"text": [
"We have previously described a partial cDNA sequence encoding a RhoGAP protein , GAP25 that is homologous to the recently reported ArhGAP9 and ArhGAP12 ."
],
"offsets": [
[
0,
153
]
]
}
] | [
{
"id": "split_0_train_48684_entity",
"type": "progene_text",
"text": [
"RhoGAP"
],
"offsets": [
[
64,
70
]
],
"normalized": []
},
{
"id": "split_0_train_48685_entity",
"type": "progene_text",
"text": [
"GAP25"
],
"offsets": [
[
81,
86
]
],
"normalized": []
},
{
"id": "split_0_train_48686_entity",
"type": "progene_text",
"text": [
"ArhGAP9"
],
"offsets": [
[
131,
138
]
],
"normalized": []
},
{
"id": "split_0_train_48687_entity",
"type": "progene_text",
"text": [
"ArhGAP12"
],
"offsets": [
[
143,
151
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30090 | split_0_train_30090 | [
{
"id": "split_0_train_30090_passage",
"type": "progene_text",
"text": [
"We now describe a related new member ArhGAP15 that shares a number of domain similarities , including a pleckstrin homology ( PH ) domain , a RhoGAP domain and a novel motif N-terminal to the GAP domain ."
],
"offsets": [
[
0,
204
]
]
}
] | [
{
"id": "split_0_train_48688_entity",
"type": "progene_text",
"text": [
"ArhGAP15"
],
"offsets": [
[
37,
45
]
],
"normalized": []
},
{
"id": "split_0_train_48689_entity",
"type": "progene_text",
"text": [
"pleckstrin"
],
"offsets": [
[
104,
114
]
],
"normalized": []
},
{
"id": "split_0_train_48690_entity",
"type": "progene_text",
"text": [
"RhoGAP"
],
"offsets": [
[
142,
148
]
],
"normalized": []
},
{
"id": "split_0_train_48691_entity",
"type": "progene_text",
"text": [
"GAP"
],
"offsets": [
[
192,
195
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30091 | split_0_train_30091 | [
{
"id": "split_0_train_30091_passage",
"type": "progene_text",
"text": [
"This novel motif was found to be responsible for nucleotide - independent Rac1 binding ."
],
"offsets": [
[
0,
88
]
]
}
] | [
{
"id": "split_0_train_48692_entity",
"type": "progene_text",
"text": [
"Rac1"
],
"offsets": [
[
74,
78
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30092 | split_0_train_30092 | [
{
"id": "split_0_train_30092_passage",
"type": "progene_text",
"text": [
"Using swop mutants of Rac / Cdc42 , we have established that the binding is through the C - terminal half of Rac1 ."
],
"offsets": [
[
0,
115
]
]
}
] | [
{
"id": "split_0_train_48693_entity",
"type": "progene_text",
"text": [
"Rac"
],
"offsets": [
[
22,
25
]
],
"normalized": []
},
{
"id": "split_0_train_48694_entity",
"type": "progene_text",
"text": [
"Cdc42"
],
"offsets": [
[
28,
33
]
],
"normalized": []
},
{
"id": "split_0_train_48695_entity",
"type": "progene_text",
"text": [
"Rac1"
],
"offsets": [
[
109,
113
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30093 | split_0_train_30093 | [
{
"id": "split_0_train_30093_passage",
"type": "progene_text",
"text": [
"The GAP domain of ArhGAP15 showed specificity towards Rac1 in vitro ."
],
"offsets": [
[
0,
69
]
]
}
] | [
{
"id": "split_0_train_48696_entity",
"type": "progene_text",
"text": [
"GAP"
],
"offsets": [
[
4,
7
]
],
"normalized": []
},
{
"id": "split_0_train_48697_entity",
"type": "progene_text",
"text": [
"ArhGAP15"
],
"offsets": [
[
18,
26
]
],
"normalized": []
},
{
"id": "split_0_train_48698_entity",
"type": "progene_text",
"text": [
"Rac1"
],
"offsets": [
[
54,
58
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30094 | split_0_train_30094 | [
{
"id": "split_0_train_30094_passage",
"type": "progene_text",
"text": [
"The PH domain is required for ArhGAP15 to localize to cell periphery and over - expression of the full - length ArhGAP15 , but not the mutant with a partial deletion of the PH domain , resulted in an increase in actin stress fibers and cell contraction ."
],
"offsets": [
[
0,
254
]
]
}
] | [
{
"id": "split_0_train_48699_entity",
"type": "progene_text",
"text": [
"ArhGAP15"
],
"offsets": [
[
30,
38
]
],
"normalized": []
},
{
"id": "split_0_train_48700_entity",
"type": "progene_text",
"text": [
"ArhGAP15"
],
"offsets": [
[
112,
120
]
],
"normalized": []
},
{
"id": "split_0_train_48701_entity",
"type": "progene_text",
"text": [
"actin"
],
"offsets": [
[
212,
217
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30095 | split_0_train_30095 | [
{
"id": "split_0_train_30095_passage",
"type": "progene_text",
"text": [
"These morphological effects can be attenuated by the co - expression of dominant negative Rac1 ( N17 ) ."
],
"offsets": [
[
0,
104
]
]
}
] | [
{
"id": "split_0_train_48702_entity",
"type": "progene_text",
"text": [
"Rac1"
],
"offsets": [
[
90,
94
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30096 | split_0_train_30096 | [
{
"id": "split_0_train_30096_passage",
"type": "progene_text",
"text": [
"HeLa cells expressing ArhGAP15 were also resistant to phorbol myristatate acetate treatment , suggesting that ArhGAP15 is a potential regulator of Rac1 ."
],
"offsets": [
[
0,
153
]
]
}
] | [
{
"id": "split_0_train_48703_entity",
"type": "progene_text",
"text": [
"ArhGAP15"
],
"offsets": [
[
22,
30
]
],
"normalized": []
},
{
"id": "split_0_train_48704_entity",
"type": "progene_text",
"text": [
"ArhGAP15"
],
"offsets": [
[
110,
118
]
],
"normalized": []
},
{
"id": "split_0_train_48705_entity",
"type": "progene_text",
"text": [
"Rac1"
],
"offsets": [
[
147,
151
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30097 | split_0_train_30097 | [
{
"id": "split_0_train_30097_passage",
"type": "progene_text",
"text": [
"MASE1 and MASE2 : two novel integral membrane sensory domains ."
],
"offsets": [
[
0,
63
]
]
}
] | [] | [] | [] | [] |
split_0_train_30098 | split_0_train_30098 | [
{
"id": "split_0_train_30098_passage",
"type": "progene_text",
"text": [
"Escherichia coli proteins YegE and YaiC contain N - terminal integral membrane regions , followed by the putative diguanylate cyclase ( GGDEF , DUF1 ) domains ."
],
"offsets": [
[
0,
160
]
]
}
] | [
{
"id": "split_0_train_48706_entity",
"type": "progene_text",
"text": [
"YegE"
],
"offsets": [
[
26,
30
]
],
"normalized": []
},
{
"id": "split_0_train_48707_entity",
"type": "progene_text",
"text": [
"YaiC"
],
"offsets": [
[
35,
39
]
],
"normalized": []
},
{
"id": "split_0_train_48708_entity",
"type": "progene_text",
"text": [
"diguanylate cyclase"
],
"offsets": [
[
114,
133
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30099 | split_0_train_30099 | [
{
"id": "split_0_train_30099_passage",
"type": "progene_text",
"text": [
"The membrane domains of these proteins , named MASE1 ( membrane - associated sensor ) and MASE2 , respectively , were found in other bacterial signaling proteins , such as histidine kinases ( MASE1 ) and an adenylate cyclase ( MASE2 ) ."
],
"offsets": [
[
0,
236
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]
}
] | [
{
"id": "split_0_train_48709_entity",
"type": "progene_text",
"text": [
"histidine kinases"
],
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[
172,
189
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],
"normalized": []
},
{
"id": "split_0_train_48710_entity",
"type": "progene_text",
"text": [
"adenylate cyclase"
],
"offsets": [
[
207,
224
]
],
"normalized": []
}
] | [] | [] | [] |