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split_0_train_30200 | split_0_train_30200 | [
{
"id": "split_0_train_30200_passage",
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"text": [
"This implies that the structure of the repressor consists of a two - domain binding protein portion attached to a DNA - binding domain having the four - helix structure of the LacI headpiece ."
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{
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"LacI"
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176,
180
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] | [] | [] | [] |
split_0_train_30201 | split_0_train_30201 | [
{
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"text": [
"The implications of these relationships to the mechanism of this class of repressors are discussed ."
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0,
100
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}
] | [] | [] | [] | [] |
split_0_train_30202 | split_0_train_30202 | [
{
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"text": [
"Characterization of the regulon controlled by the leucine - responsive regulatory protein in Escherichia coli ."
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111
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{
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"text": [
"leucine - responsive regulatory protein"
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50,
89
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] | [] | [] | [] |
split_0_train_30203 | split_0_train_30203 | [
{
"id": "split_0_train_30203_passage",
"type": "progene_text",
"text": [
"The leucine - responsive regulatory protein ( Lrp ) has been shown to regulate , either positively or negatively , the transcription of several Escherichia coli genes in response to leucine ."
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0,
191
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"text": [
"Lrp"
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46,
49
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] | [] | [] | [] |
split_0_train_30204 | split_0_train_30204 | [
{
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"type": "progene_text",
"text": [
"We have used two - dimensional gel electrophoresis to analyze the patterns of polypeptide expression in isogenic lrp + and lrp mutant strains in the presence or absence of leucine ."
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181
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"lrp"
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123,
126
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] | [] | [] | [] |
split_0_train_30205 | split_0_train_30205 | [
{
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"type": "progene_text",
"text": [
"The absence of a functional Lrp protein alters the expression of at least 30 polypeptides ."
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91
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"Lrp"
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28,
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] | [] | [] | [] |
split_0_train_30206 | split_0_train_30206 | [
{
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"text": [
"The expression of the majority of these polypeptides is not affected by the presence or absence of 10 mM exogenous leucine ."
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0,
124
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]
}
] | [] | [] | [] | [] |
split_0_train_30207 | split_0_train_30207 | [
{
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"text": [
"Outer membrane porins OmpC and OmpF , glutamine synthetase ( GlnA ) , the small subunit of glutamate synthase ( GltD ) , lysyl - tRNA synthetase form II ( LysU ) , a high - affinity periplasmic binding protein specific for branched - chain amino acids ( LivJ ) , W protein , and the enzymes of the pathway converting threonine to glycine , namely , threonine dehydrogenase ( Tdh ) and 2-amino-3-ketobutyrate coenzyme A ligase ( Kbl ) , were identified as members of the Lrp regulon by electrophoretic analysis ."
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{
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112,
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{
"id": "split_0_train_48878_entity",
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"text": [
"lysyl - tRNA synthetase"
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121,
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{
"id": "split_0_train_48879_entity",
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"text": [
"LysU"
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155,
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{
"id": "split_0_train_48880_entity",
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"text": [
"threonine dehydrogenase"
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349,
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{
"id": "split_0_train_48881_entity",
"type": "progene_text",
"text": [
"Tdh"
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375,
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{
"id": "split_0_train_48882_entity",
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"text": [
"2-amino-3-ketobutyrate coenzyme A ligase"
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{
"id": "split_0_train_48883_entity",
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"Kbl"
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{
"id": "split_0_train_48884_entity",
"type": "progene_text",
"text": [
"Lrp"
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470,
473
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30208 | split_0_train_30208 | [
{
"id": "split_0_train_30208_passage",
"type": "progene_text",
"text": [
"We have shown that Lrp is a positive regulator of glutamate synthase and glutamine synthetase and that exogenous leucine has little or no effect on the expression of these proteins ."
],
"offsets": [
[
0,
182
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]
}
] | [
{
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"type": "progene_text",
"text": [
"Lrp"
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19,
22
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{
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"type": "progene_text",
"text": [
"glutamate synthase"
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50,
68
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},
{
"id": "split_0_train_48887_entity",
"type": "progene_text",
"text": [
"glutamine synthetase"
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"offsets": [
[
73,
93
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30209 | split_0_train_30209 | [
{
"id": "split_0_train_30209_passage",
"type": "progene_text",
"text": [
"In strains carrying a glnL deletion and in strains carrying the glnL2302 allele , which directs the synthesis of a GlnL protein that is constitutively active , expression of glutamine synthetase is no longer regulated by Lrp , demonstrating that the effect of Lrp on glutamine synthetase levels is indirect and requires an intact glnL gene ."
],
"offsets": [
[
0,
341
]
]
}
] | [
{
"id": "split_0_train_48888_entity",
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"glnL"
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22,
26
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{
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"glnL2302"
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64,
72
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{
"id": "split_0_train_48890_entity",
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"GlnL"
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115,
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{
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{
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221,
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{
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"Lrp"
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260,
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},
{
"id": "split_0_train_48894_entity",
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"text": [
"glutamine synthetase"
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267,
287
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{
"id": "split_0_train_48895_entity",
"type": "progene_text",
"text": [
"glnL"
],
"offsets": [
[
330,
334
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30210 | split_0_train_30210 | [
{
"id": "split_0_train_30210_passage",
"type": "progene_text",
"text": [
"lrp : : Tn10 strains grow poorly when arginine or ornithine is present as the sole nitrogen source in the medium ."
],
"offsets": [
[
0,
114
]
]
}
] | [
{
"id": "split_0_train_48896_entity",
"type": "progene_text",
"text": [
"lrp"
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"offsets": [
[
0,
3
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30211 | split_0_train_30211 | [
{
"id": "split_0_train_30211_passage",
"type": "progene_text",
"text": [
"On the bases of present studies and previous research , we propose that Lrp is involved in the adaptation of E. coli cells to major shifts in environment , such as those which occur when E. coli leaves the intestinal tract of its animal host ."
],
"offsets": [
[
0,
243
]
]
}
] | [
{
"id": "split_0_train_48897_entity",
"type": "progene_text",
"text": [
"Lrp"
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"offsets": [
[
72,
75
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30212 | split_0_train_30212 | [
{
"id": "split_0_train_30212_passage",
"type": "progene_text",
"text": [
"Several genes required for amino acid and peptide transport and catabolism are negatively regulated by Lrp , and other genes required for amino acid biosynthesis and ammonia assimilation in a nitrogen - poor environment are positively regulated by Lrp ."
],
"offsets": [
[
0,
253
]
]
}
] | [
{
"id": "split_0_train_48898_entity",
"type": "progene_text",
"text": [
"Lrp"
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103,
106
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{
"id": "split_0_train_48899_entity",
"type": "progene_text",
"text": [
"Lrp"
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"offsets": [
[
248,
251
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30213 | split_0_train_30213 | [
{
"id": "split_0_train_30213_passage",
"type": "progene_text",
"text": [
"Prospecting for novel biocatalysts in a soil metagenome ."
],
"offsets": [
[
0,
57
]
]
}
] | [] | [] | [] | [] |
split_0_train_30214 | split_0_train_30214 | [
{
"id": "split_0_train_30214_passage",
"type": "progene_text",
"text": [
"The metagenomes of complex microbial communities are rich sources of novel biocatalysts ."
],
"offsets": [
[
0,
89
]
]
}
] | [] | [] | [] | [] |
split_0_train_30215 | split_0_train_30215 | [
{
"id": "split_0_train_30215_passage",
"type": "progene_text",
"text": [
"We exploited the metagenome of a mixed microbial population for isolation of more than 15 different genes encoding novel biocatalysts by using a combined cultivation and direct cloning strategy ."
],
"offsets": [
[
0,
195
]
]
}
] | [] | [] | [] | [] |
split_0_train_30216 | split_0_train_30216 | [
{
"id": "split_0_train_30216_passage",
"type": "progene_text",
"text": [
"A 16S rRNA sequence analysis revealed the presence of hitherto uncultured microbes closely related to the genera Pseudomonas , Agrobacterium , Xanthomonas , Microbulbifer , and Janthinobacterium ."
],
"offsets": [
[
0,
196
]
]
}
] | [] | [] | [] | [] |
split_0_train_30217 | split_0_train_30217 | [
{
"id": "split_0_train_30217_passage",
"type": "progene_text",
"text": [
"Total genomic DNA from this bacterial community was used to construct cosmid DNA libraries , which were functionally searched for novel enzymes of biotechnological value ."
],
"offsets": [
[
0,
171
]
]
}
] | [] | [] | [] | [] |
split_0_train_30218 | split_0_train_30218 | [
{
"id": "split_0_train_30218_passage",
"type": "progene_text",
"text": [
"Our searches in combination with cosmid sequencing resulted in identification of four clones encoding 12 putative agarase genes , most of which were organized in clusters consisting of two or three genes ."
],
"offsets": [
[
0,
205
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]
}
] | [
{
"id": "split_0_train_48900_entity",
"type": "progene_text",
"text": [
"agarase"
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"offsets": [
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114,
121
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30219 | split_0_train_30219 | [
{
"id": "split_0_train_30219_passage",
"type": "progene_text",
"text": [
"Interestingly , nine of these agarase genes probably originated from gene duplications ."
],
"offsets": [
[
0,
88
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]
}
] | [
{
"id": "split_0_train_48901_entity",
"type": "progene_text",
"text": [
"agarase"
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"offsets": [
[
30,
37
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30220 | split_0_train_30220 | [
{
"id": "split_0_train_30220_passage",
"type": "progene_text",
"text": [
"Furthermore , we identified by DNA sequencing several other biocatalyst - encoding genes , including genes encoding a putative stereoselective amidase ( amiA ) , two cellulases ( gnuB and uvs080 ) , an alpha-amylase ( amyA ) , a 1,4-alpha-glucan branching enzyme ( amyB ) , and two pectate lyases ( pelA and uvs119 ) ."
],
"offsets": [
[
0,
318
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]
}
] | [
{
"id": "split_0_train_48902_entity",
"type": "progene_text",
"text": [
"amidase"
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143,
150
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{
"id": "split_0_train_48903_entity",
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"amiA"
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153,
157
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{
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"text": [
"cellulases"
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166,
176
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{
"id": "split_0_train_48905_entity",
"type": "progene_text",
"text": [
"gnuB"
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179,
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188,
194
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{
"id": "split_0_train_48907_entity",
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"text": [
"alpha-amylase"
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202,
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{
"id": "split_0_train_48908_entity",
"type": "progene_text",
"text": [
"amyA"
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218,
222
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{
"id": "split_0_train_48909_entity",
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"text": [
"1,4-alpha-glucan branching enzyme"
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229,
262
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{
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"amyB"
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265,
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{
"id": "split_0_train_48911_entity",
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"text": [
"pectate lyases"
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282,
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{
"id": "split_0_train_48912_entity",
"type": "progene_text",
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"pelA"
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299,
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{
"id": "split_0_train_48913_entity",
"type": "progene_text",
"text": [
"uvs119"
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[
308,
314
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30221 | split_0_train_30221 | [
{
"id": "split_0_train_30221_passage",
"type": "progene_text",
"text": [
"Also , a conserved cluster of two lipase genes was identified , which was linked to genes encoding a type I secretion system ."
],
"offsets": [
[
0,
126
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]
}
] | [
{
"id": "split_0_train_48914_entity",
"type": "progene_text",
"text": [
"lipase"
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"offsets": [
[
34,
40
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30222 | split_0_train_30222 | [
{
"id": "split_0_train_30222_passage",
"type": "progene_text",
"text": [
"The novel gene aguB was overexpressed in Escherichia coli , and the enzyme activities were determined ."
],
"offsets": [
[
0,
103
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]
}
] | [
{
"id": "split_0_train_48915_entity",
"type": "progene_text",
"text": [
"aguB"
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"offsets": [
[
15,
19
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30223 | split_0_train_30223 | [
{
"id": "split_0_train_30223_passage",
"type": "progene_text",
"text": [
"Finally , we describe more than 162 kb of DNA sequence that provides a strong platform for further characterization of this microbial consortium ."
],
"offsets": [
[
0,
146
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]
}
] | [] | [] | [] | [] |
split_0_train_30224 | split_0_train_30224 | [
{
"id": "split_0_train_30224_passage",
"type": "progene_text",
"text": [
"Cloning and characterization of the mouse AP-2 epsilon gene : a novel family member expressed in the developing olfactory bulb ."
],
"offsets": [
[
0,
128
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]
}
] | [
{
"id": "split_0_train_48916_entity",
"type": "progene_text",
"text": [
"AP-2 epsilon"
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42,
54
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30225 | split_0_train_30225 | [
{
"id": "split_0_train_30225_passage",
"type": "progene_text",
"text": [
"Members of the mammalian AP-2 transcription factor family have critical regulatory roles in many aspects of development and are also implicated in cancer progression ."
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"offsets": [
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0,
167
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}
] | [
{
"id": "split_0_train_48917_entity",
"type": "progene_text",
"text": [
"AP-2 transcription factor family"
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"offsets": [
[
25,
57
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"normalized": []
}
] | [] | [] | [] |
split_0_train_30226 | split_0_train_30226 | [
{
"id": "split_0_train_30226_passage",
"type": "progene_text",
"text": [
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0,
144
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] | [
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"id": "split_0_train_48919_entity",
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85,
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124,
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}
] | [] | [] | [] |
split_0_train_30227 | split_0_train_30227 | [
{
"id": "split_0_train_30227_passage",
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"text": [
"Here we report the cloning and characterization of the fifth member of the vertebrate AP-2 family , AP-2epsilon ."
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"text": [
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100,
111
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}
] | [] | [] | [] |
split_0_train_30228 | split_0_train_30228 | [
{
"id": "split_0_train_30228_passage",
"type": "progene_text",
"text": [
"The AP-2epsilon protein is very similar to the other family members in its DNA binding and dimerization domain and also contains conserved proline and aromatic amino acid residues in the activation domain ."
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206
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}
] | [] | [] | [] |
split_0_train_30229 | split_0_train_30229 | [
{
"id": "split_0_train_30229_passage",
"type": "progene_text",
"text": [
"Consistent with these observations , AP-2epsilon can bind to the GC - rich AP-2 consensus sequence and can dimerize either with itself or with any of the other AP-2 proteins ."
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0,
175
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}
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{
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75,
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"id": "split_0_train_48928_entity",
"type": "progene_text",
"text": [
"AP-2"
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160,
164
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}
] | [] | [] | [] |
split_0_train_30230 | split_0_train_30230 | [
{
"id": "split_0_train_30230_passage",
"type": "progene_text",
"text": [
"The AP-2epsilon protein is also able to activate transcription in a binding site - dependent manner ."
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101
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}
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{
"id": "split_0_train_48929_entity",
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"text": [
"AP-2epsilon"
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4,
15
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],
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}
] | [] | [] | [] |
split_0_train_30231 | split_0_train_30231 | [
{
"id": "split_0_train_30231_passage",
"type": "progene_text",
"text": [
"However , the mouse AP-2epsilon gene is distinctive from the other AP-2 genes in its pattern of expression during embryogenesis ."
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[
0,
129
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}
] | [
{
"id": "split_0_train_48930_entity",
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{
"id": "split_0_train_48931_entity",
"type": "progene_text",
"text": [
"AP-2"
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67,
71
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],
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}
] | [] | [] | [] |
split_0_train_30232 | split_0_train_30232 | [
{
"id": "split_0_train_30232_passage",
"type": "progene_text",
"text": [
"Unlike AP-2alpha , AP-2beta , and AP-2gamma , transcripts corresponding to AP-2epsilon are not found in the neural crest and its derivatives ."
],
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0,
142
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]
}
] | [
{
"id": "split_0_train_48932_entity",
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{
"id": "split_0_train_48933_entity",
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19,
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{
"id": "split_0_train_48934_entity",
"type": "progene_text",
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34,
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{
"id": "split_0_train_48935_entity",
"type": "progene_text",
"text": [
"AP-2epsilon"
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[
75,
86
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30233 | split_0_train_30233 | [
{
"id": "split_0_train_30233_passage",
"type": "progene_text",
"text": [
"Instead , AP-2epsilon is expressed most prominently in the mitral cell layer of the developing olfactory bulb ."
],
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[
0,
111
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]
}
] | [
{
"id": "split_0_train_48936_entity",
"type": "progene_text",
"text": [
"AP-2epsilon"
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"offsets": [
[
10,
21
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30234 | split_0_train_30234 | [
{
"id": "split_0_train_30234_passage",
"type": "progene_text",
"text": [
"A comparison of AP-2 gene family expression in the olfactory system suggests both distinct and overlapping functions for these transcription factors in forebrain development ."
],
"offsets": [
[
0,
175
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]
}
] | [
{
"id": "split_0_train_48937_entity",
"type": "progene_text",
"text": [
"AP-2"
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16,
20
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},
{
"id": "split_0_train_48938_entity",
"type": "progene_text",
"text": [
"transcription factors"
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127,
148
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30235 | split_0_train_30235 | [
{
"id": "split_0_train_30235_passage",
"type": "progene_text",
"text": [
"Gene expression of transforming growth factor beta receptors I and II in non - small - cell lung tumors ."
],
"offsets": [
[
0,
105
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]
}
] | [
{
"id": "split_0_train_48939_entity",
"type": "progene_text",
"text": [
"transforming growth factor beta receptors I and II"
],
"offsets": [
[
19,
69
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30236 | split_0_train_30236 | [
{
"id": "split_0_train_30236_passage",
"type": "progene_text",
"text": [
"Transforming growth factor ( TGF ) beta inhibits normal epithelial cell proliferation ."
],
"offsets": [
[
0,
87
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]
}
] | [
{
"id": "split_0_train_48940_entity",
"type": "progene_text",
"text": [
"Transforming growth factor ( TGF ) beta"
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"offsets": [
[
0,
39
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30237 | split_0_train_30237 | [
{
"id": "split_0_train_30237_passage",
"type": "progene_text",
"text": [
"A decreased expression of TGFbeta receptors ( TbetaR ) has been associated with loss of TGFbeta sensitivity and enhanced tumor progression in many types of cancer ."
],
"offsets": [
[
0,
164
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]
}
] | [
{
"id": "split_0_train_48941_entity",
"type": "progene_text",
"text": [
"TGFbeta receptors"
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26,
43
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{
"id": "split_0_train_48942_entity",
"type": "progene_text",
"text": [
"TbetaR"
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46,
52
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"normalized": []
},
{
"id": "split_0_train_48943_entity",
"type": "progene_text",
"text": [
"TGFbeta"
],
"offsets": [
[
88,
95
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30238 | split_0_train_30238 | [
{
"id": "split_0_train_30238_passage",
"type": "progene_text",
"text": [
"Although lung cancer is one of the leading causes of cancer death , a comparative analysis of TbetaR mRNA and protein expression in non - small - cell ( NSC ) lung tumors has not been performed ."
],
"offsets": [
[
0,
195
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]
}
] | [
{
"id": "split_0_train_48944_entity",
"type": "progene_text",
"text": [
"TbetaR"
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"offsets": [
[
94,
100
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30239 | split_0_train_30239 | [
{
"id": "split_0_train_30239_passage",
"type": "progene_text",
"text": [
"Lung tumor tissues and control non - lesional lung tissues were obtained from 17 patients undergoing thoracotomy for primary NSC lung tumors in clinical stage II ."
],
"offsets": [
[
0,
163
]
]
}
] | [] | [] | [] | [] |
split_0_train_30240 | split_0_train_30240 | [
{
"id": "split_0_train_30240_passage",
"type": "progene_text",
"text": [
"Each tissue sample was studied for TbetaRI and TbetaRII mRNA and immunoreactive protein expression , using a semi - quantitative reverse transcription - PCR method , and a quantitative immunohistochemistry method , respectively ."
],
"offsets": [
[
0,
229
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]
}
] | [
{
"id": "split_0_train_48945_entity",
"type": "progene_text",
"text": [
"TbetaRI"
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35,
42
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"normalized": []
},
{
"id": "split_0_train_48946_entity",
"type": "progene_text",
"text": [
"TbetaRII"
],
"offsets": [
[
47,
55
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30241 | split_0_train_30241 | [
{
"id": "split_0_train_30241_passage",
"type": "progene_text",
"text": [
"TbetaRI protein expression was higher in tumors than in controls ( p = 0.0005 ) and a similar trend was present at the mRNA level ."
],
"offsets": [
[
0,
131
]
]
}
] | [
{
"id": "split_0_train_48947_entity",
"type": "progene_text",
"text": [
"TbetaRI"
],
"offsets": [
[
0,
7
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30242 | split_0_train_30242 | [
{
"id": "split_0_train_30242_passage",
"type": "progene_text",
"text": [
"TbetaRII protein expression was not significantly different between tumors and controls , however an intense peri - nuclear staining for TbetaRII was observed in several tumor cells ."
],
"offsets": [
[
0,
183
]
]
}
] | [
{
"id": "split_0_train_48948_entity",
"type": "progene_text",
"text": [
"TbetaRII"
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0,
8
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"normalized": []
},
{
"id": "split_0_train_48949_entity",
"type": "progene_text",
"text": [
"TbetaRII"
],
"offsets": [
[
137,
145
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30243 | split_0_train_30243 | [
{
"id": "split_0_train_30243_passage",
"type": "progene_text",
"text": [
"TbetaRII mRNA levels were lower in tumors than in controls ( p = 0.005 ) and an inverse relation between TbetaRII mRNA and protein expression was detected in tumors ( p = 0.0013 ) ."
],
"offsets": [
[
0,
181
]
]
}
] | [
{
"id": "split_0_train_48950_entity",
"type": "progene_text",
"text": [
"TbetaRII"
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0,
8
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},
{
"id": "split_0_train_48951_entity",
"type": "progene_text",
"text": [
"TbetaRII"
],
"offsets": [
[
105,
113
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30244 | split_0_train_30244 | [
{
"id": "split_0_train_30244_passage",
"type": "progene_text",
"text": [
"Our findings suggest an altered function of the TbetaR system in NSC lung cancer ."
],
"offsets": [
[
0,
82
]
]
}
] | [
{
"id": "split_0_train_48952_entity",
"type": "progene_text",
"text": [
"TbetaR"
],
"offsets": [
[
48,
54
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30245 | split_0_train_30245 | [
{
"id": "split_0_train_30245_passage",
"type": "progene_text",
"text": [
"A Korean kindred with autosomal dominant nocturnal frontal lobe epilepsy and mental retardation ."
],
"offsets": [
[
0,
97
]
]
}
] | [] | [] | [] | [] |
split_0_train_30246 | split_0_train_30246 | [
{
"id": "split_0_train_30246_passage",
"type": "progene_text",
"text": [
"BACKGROUND :"
],
"offsets": [
[
0,
12
]
]
}
] | [] | [] | [] | [] |
split_0_train_30247 | split_0_train_30247 | [
{
"id": "split_0_train_30247_passage",
"type": "progene_text",
"text": [
"A Korean family had distinctive clinical and neuroimaging features and carried the same genetic mutation that was found in a previously described Japanese kindred with autosomal dominant nocturnal frontal lobe epilepsy ."
],
"offsets": [
[
0,
220
]
]
}
] | [] | [] | [] | [] |
split_0_train_30248 | split_0_train_30248 | [
{
"id": "split_0_train_30248_passage",
"type": "progene_text",
"text": [
"OBJECTIVE :"
],
"offsets": [
[
0,
11
]
]
}
] | [] | [] | [] | [] |
split_0_train_30249 | split_0_train_30249 | [
{
"id": "split_0_train_30249_passage",
"type": "progene_text",
"text": [
"To describe the first Korean family with autosomal dominant nocturnal frontal lobe epilepsy ."
],
"offsets": [
[
0,
93
]
]
}
] | [] | [] | [] | [] |
split_0_train_30250 | split_0_train_30250 | [
{
"id": "split_0_train_30250_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
] | [] | [] | [] | [] |
split_0_train_30251 | split_0_train_30251 | [
{
"id": "split_0_train_30251_passage",
"type": "progene_text",
"text": [
"Members of a large family , including 9 affected individuals from 3 generations , underwent a comprehensive genetic , clinical , electroencephalographic , neuropsychological , and neuroimaging evaluation ."
],
"offsets": [
[
0,
205
]
]
}
] | [] | [] | [] | [] |
split_0_train_30252 | split_0_train_30252 | [
{
"id": "split_0_train_30252_passage",
"type": "progene_text",
"text": [
"Affected members were tested for possible mutations in transmembrane regions 1 through 3 of the neuronal nicotinic acetylcholine receptor alpha4 subunit ( CHRNA4 ) by direct sequencing and subsequent restriction analysis ."
],
"offsets": [
[
0,
222
]
]
}
] | [
{
"id": "split_0_train_48953_entity",
"type": "progene_text",
"text": [
"neuronal nicotinic acetylcholine receptor alpha4"
],
"offsets": [
[
96,
144
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],
"normalized": []
},
{
"id": "split_0_train_48954_entity",
"type": "progene_text",
"text": [
"CHRNA4"
],
"offsets": [
[
155,
161
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30253 | split_0_train_30253 | [
{
"id": "split_0_train_30253_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] | [] | [] | [] | [] |
split_0_train_30254 | split_0_train_30254 | [
{
"id": "split_0_train_30254_passage",
"type": "progene_text",
"text": [
"Seizures began in childhood , presenting as nocturnal episodes of staring , confusion , shouting , perioral movements , unintelligible speech , and hand waving ."
],
"offsets": [
[
0,
161
]
]
}
] | [] | [] | [] | [] |
split_0_train_30255 | split_0_train_30255 | [
{
"id": "split_0_train_30255_passage",
"type": "progene_text",
"text": [
"Some patients had ictal or interictal epileptiform activity in the temporal and/or frontocentral areas ."
],
"offsets": [
[
0,
104
]
]
}
] | [] | [] | [] | [] |
split_0_train_30256 | split_0_train_30256 | [
{
"id": "split_0_train_30256_passage",
"type": "progene_text",
"text": [
"Neurological examination and brain magnetic resonance imaging results showed no abnormalities , except that all patients available for testing had mild to moderate mental retardation ."
],
"offsets": [
[
0,
184
]
]
}
] | [] | [] | [] | [] |
split_0_train_30257 | split_0_train_30257 | [
{
"id": "split_0_train_30257_passage",
"type": "progene_text",
"text": [
"Fluorodeoxyglucose F 18 with positron emission tomography showed mild decreased glucose uptake in the superior and middle frontal regions , more so on the left than on the right ."
],
"offsets": [
[
0,
179
]
]
}
] | [] | [] | [] | [] |
split_0_train_30258 | split_0_train_30258 | [
{
"id": "split_0_train_30258_passage",
"type": "progene_text",
"text": [
"Patient response to carbamazepine was poor ."
],
"offsets": [
[
0,
44
]
]
}
] | [] | [] | [] | [] |
split_0_train_30259 | split_0_train_30259 | [
{
"id": "split_0_train_30259_passage",
"type": "progene_text",
"text": [
"All affected members were heterozygous for the CHRNA4 Ser252Leu mutation ."
],
"offsets": [
[
0,
74
]
]
}
] | [
{
"id": "split_0_train_48955_entity",
"type": "progene_text",
"text": [
"CHRNA4"
],
"offsets": [
[
47,
53
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30260 | split_0_train_30260 | [
{
"id": "split_0_train_30260_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
] | [] | [] | [] | [] |
split_0_train_30261 | split_0_train_30261 | [
{
"id": "split_0_train_30261_passage",
"type": "progene_text",
"text": [
"Disorders associated with mutations in the transmembrane region 2 of CHRNA4 are genetically and phenotypically heterogeneous ."
],
"offsets": [
[
0,
126
]
]
}
] | [
{
"id": "split_0_train_48956_entity",
"type": "progene_text",
"text": [
"CHRNA4"
],
"offsets": [
[
69,
75
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30262 | split_0_train_30262 | [
{
"id": "split_0_train_30262_passage",
"type": "progene_text",
"text": [
"Distinctive features of this kindred include ( 1 ) mental retardation in all affected members available for testing , ( 2 ) abnormal brain findings on fluorodeoxyglucose F 18 with positron emission tomography , ( 3 ) poor response to carbamazepine , and ( 4 ) full penetrance ."
],
"offsets": [
[
0,
277
]
]
}
] | [] | [] | [] | [] |
split_0_train_30263 | split_0_train_30263 | [
{
"id": "split_0_train_30263_passage",
"type": "progene_text",
"text": [
"Crystal structure of the RluD pseudouridine synthase catalytic module , an enzyme that modifies 23S rRNA and is essential for normal cell growth of Escherichia coli ."
],
"offsets": [
[
0,
166
]
]
}
] | [
{
"id": "split_0_train_48957_entity",
"type": "progene_text",
"text": [
"RluD pseudouridine synthase"
],
"offsets": [
[
25,
52
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30264 | split_0_train_30264 | [
{
"id": "split_0_train_30264_passage",
"type": "progene_text",
"text": [
"Pseudouridine ( 5-beta-D-ribofuranosyluracil , Psi ) is the most commonly found modified base in RNA ."
],
"offsets": [
[
0,
102
]
]
}
] | [] | [] | [] | [] |
split_0_train_30265 | split_0_train_30265 | [
{
"id": "split_0_train_30265_passage",
"type": "progene_text",
"text": [
"Conversion of uridine to Psi is performed enzymatically in both prokaryotes and eukaryotes by pseudouridine synthases ( EC 4.2.1.70 ) ."
],
"offsets": [
[
0,
135
]
]
}
] | [
{
"id": "split_0_train_48958_entity",
"type": "progene_text",
"text": [
"pseudouridine synthases"
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[
94,
117
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],
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},
{
"id": "split_0_train_48959_entity",
"type": "progene_text",
"text": [
"EC 4.2.1.70"
],
"offsets": [
[
120,
131
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30266 | split_0_train_30266 | [
{
"id": "split_0_train_30266_passage",
"type": "progene_text",
"text": [
"The Escherichia coli Psi - synthase RluD modifies uridine to Psi at positions 1911 , 1915 and 1917 within 23S rRNA ."
],
"offsets": [
[
0,
116
]
]
}
] | [
{
"id": "split_0_train_48960_entity",
"type": "progene_text",
"text": [
"Psi - synthase"
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"offsets": [
[
21,
35
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],
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},
{
"id": "split_0_train_48961_entity",
"type": "progene_text",
"text": [
"RluD"
],
"offsets": [
[
36,
40
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30267 | split_0_train_30267 | [
{
"id": "split_0_train_30267_passage",
"type": "progene_text",
"text": [
"RluD also possesses a second function related to proper assembly of the 50S ribosomal subunit that is independent of Psi - synthesis ."
],
"offsets": [
[
0,
134
]
]
}
] | [
{
"id": "split_0_train_48962_entity",
"type": "progene_text",
"text": [
"RluD"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30268 | split_0_train_30268 | [
{
"id": "split_0_train_30268_passage",
"type": "progene_text",
"text": [
"Here , we report the crystal structure of the catalytic module of RluD ( residues 68 - 326 ; DeltaRluD ) refined at 1.8A to a final R - factor of 21.8 % ( R ( free ) = 24.3 % ) ."
],
"offsets": [
[
0,
178
]
]
}
] | [
{
"id": "split_0_train_48963_entity",
"type": "progene_text",
"text": [
"RluD"
],
"offsets": [
[
66,
70
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30269 | split_0_train_30269 | [
{
"id": "split_0_train_30269_passage",
"type": "progene_text",
"text": [
"DeltaRluD is a monomeric enzyme having an overall mixed alpha / beta fold ."
],
"offsets": [
[
0,
75
]
]
}
] | [
{
"id": "split_0_train_48964_entity",
"type": "progene_text",
"text": [
"DeltaRluD"
],
"offsets": [
[
0,
9
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30270 | split_0_train_30270 | [
{
"id": "split_0_train_30270_passage",
"type": "progene_text",
"text": [
"The DeltaRluD molecule consists of two subdomains , a catalytic subdomain and C - terminal subdomain with the RNA - binding cleft formed by loops extending from the catalytic sub - domain ."
],
"offsets": [
[
0,
189
]
]
}
] | [
{
"id": "split_0_train_48965_entity",
"type": "progene_text",
"text": [
"DeltaRluD"
],
"offsets": [
[
4,
13
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30271 | split_0_train_30271 | [
{
"id": "split_0_train_30271_passage",
"type": "progene_text",
"text": [
"The catalytic sub - domain of DeltaRluD has a similar fold as in TruA , TruB and RsuA , with the location of the RNA - binding cleft , active - site and conserved , catalytic Asp residue superposing in all four structures ."
],
"offsets": [
[
0,
223
]
]
}
] | [
{
"id": "split_0_train_48966_entity",
"type": "progene_text",
"text": [
"DeltaRluD"
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[
30,
39
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],
"normalized": []
},
{
"id": "split_0_train_48967_entity",
"type": "progene_text",
"text": [
"TruA"
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[
65,
69
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],
"normalized": []
},
{
"id": "split_0_train_48968_entity",
"type": "progene_text",
"text": [
"TruB"
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"offsets": [
[
72,
76
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],
"normalized": []
},
{
"id": "split_0_train_48969_entity",
"type": "progene_text",
"text": [
"RsuA"
],
"offsets": [
[
81,
85
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30272 | split_0_train_30272 | [
{
"id": "split_0_train_30272_passage",
"type": "progene_text",
"text": [
"Superposition of the crystal structure of TruB bound to a T - stem loop with RluD reveals that similar RNA - protein interactions for the flipped - out uridine base would exist in both structures , implying that base - flipping is necessary for catalysis ."
],
"offsets": [
[
0,
256
]
]
}
] | [
{
"id": "split_0_train_48970_entity",
"type": "progene_text",
"text": [
"TruB"
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[
42,
46
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],
"normalized": []
},
{
"id": "split_0_train_48971_entity",
"type": "progene_text",
"text": [
"RluD"
],
"offsets": [
[
77,
81
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30273 | split_0_train_30273 | [
{
"id": "split_0_train_30273_passage",
"type": "progene_text",
"text": [
"This observation also implies that the specificity determinants for site - specific RNA - binding and recognition likely reside in parts of RluD beyond the active site ."
],
"offsets": [
[
0,
169
]
]
}
] | [
{
"id": "split_0_train_48972_entity",
"type": "progene_text",
"text": [
"RluD"
],
"offsets": [
[
140,
144
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30274 | split_0_train_30274 | [
{
"id": "split_0_train_30274_passage",
"type": "progene_text",
"text": [
"Interleukin-4 inhibits platelet - derived growth factor - induced preadipocyte proliferation ."
],
"offsets": [
[
0,
94
]
]
}
] | [
{
"id": "split_0_train_48973_entity",
"type": "progene_text",
"text": [
"Interleukin-4"
],
"offsets": [
[
0,
13
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],
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},
{
"id": "split_0_train_48974_entity",
"type": "progene_text",
"text": [
"platelet - derived growth factor"
],
"offsets": [
[
23,
55
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30275 | split_0_train_30275 | [
{
"id": "split_0_train_30275_passage",
"type": "progene_text",
"text": [
"Interleukin-4 ( IL-4 ) activates STAT6 in 3T3-L1 preadipocytes but its functional role is not known ."
],
"offsets": [
[
0,
101
]
]
}
] | [
{
"id": "split_0_train_48975_entity",
"type": "progene_text",
"text": [
"Interleukin-4"
],
"offsets": [
[
0,
13
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],
"normalized": []
},
{
"id": "split_0_train_48976_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
16,
20
]
],
"normalized": []
},
{
"id": "split_0_train_48977_entity",
"type": "progene_text",
"text": [
"STAT6"
],
"offsets": [
[
33,
38
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30276 | split_0_train_30276 | [
{
"id": "split_0_train_30276_passage",
"type": "progene_text",
"text": [
"In this report , we first assessed interleukin-4 receptor alpha ( IL-4Ralpha ) expression during adipogenesis ."
],
"offsets": [
[
0,
111
]
]
}
] | [
{
"id": "split_0_train_48978_entity",
"type": "progene_text",
"text": [
"interleukin-4 receptor alpha"
],
"offsets": [
[
35,
63
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],
"normalized": []
},
{
"id": "split_0_train_48979_entity",
"type": "progene_text",
"text": [
"IL-4Ralpha"
],
"offsets": [
[
66,
76
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30277 | split_0_train_30277 | [
{
"id": "split_0_train_30277_passage",
"type": "progene_text",
"text": [
"IL-4Ralpha was highly expressed in proliferating 3T3-L1 preadipocytes ."
],
"offsets": [
[
0,
71
]
]
}
] | [
{
"id": "split_0_train_48980_entity",
"type": "progene_text",
"text": [
"IL-4Ralpha"
],
"offsets": [
[
0,
10
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30278 | split_0_train_30278 | [
{
"id": "split_0_train_30278_passage",
"type": "progene_text",
"text": [
"Receptor expression was down - regulated in post - confluent growth arrested preadipocytes ."
],
"offsets": [
[
0,
92
]
]
}
] | [] | [] | [] | [] |
split_0_train_30279 | split_0_train_30279 | [
{
"id": "split_0_train_30279_passage",
"type": "progene_text",
"text": [
"Induction of differentiation led to a transient 36 - h increase in expression , but then levels decreased to undetectable amounts 3 - 8 days after induction of differentiation ."
],
"offsets": [
[
0,
177
]
]
}
] | [] | [] | [] | [] |
split_0_train_30280 | split_0_train_30280 | [
{
"id": "split_0_train_30280_passage",
"type": "progene_text",
"text": [
"Depending on the cell type , IL-4 either increases or decreases cell proliferation ."
],
"offsets": [
[
0,
84
]
]
}
] | [
{
"id": "split_0_train_48981_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
29,
33
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30281 | split_0_train_30281 | [
{
"id": "split_0_train_30281_passage",
"type": "progene_text",
"text": [
"In growth arrested preconfluent 3T3-L1 preadipocytes , IL-4 alone had no effect on preadipocyte proliferation ."
],
"offsets": [
[
0,
111
]
]
}
] | [
{
"id": "split_0_train_48982_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
55,
59
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30282 | split_0_train_30282 | [
{
"id": "split_0_train_30282_passage",
"type": "progene_text",
"text": [
"In contrast , IL-4 inhibited platelet - derived growth factor ( PDGF-BB ) induced preadipocyte proliferation ."
],
"offsets": [
[
0,
110
]
]
}
] | [
{
"id": "split_0_train_48983_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "split_0_train_48984_entity",
"type": "progene_text",
"text": [
"platelet - derived growth factor"
],
"offsets": [
[
29,
61
]
],
"normalized": []
},
{
"id": "split_0_train_48985_entity",
"type": "progene_text",
"text": [
"PDGF-BB"
],
"offsets": [
[
64,
71
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30283 | split_0_train_30283 | [
{
"id": "split_0_train_30283_passage",
"type": "progene_text",
"text": [
"PDGF-BB , but not IL-4 , induced STAT3 tyrosine and AKT serine phosphorylation ."
],
"offsets": [
[
0,
80
]
]
}
] | [
{
"id": "split_0_train_48986_entity",
"type": "progene_text",
"text": [
"PDGF-BB"
],
"offsets": [
[
0,
7
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],
"normalized": []
},
{
"id": "split_0_train_48987_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
18,
22
]
],
"normalized": []
},
{
"id": "split_0_train_48988_entity",
"type": "progene_text",
"text": [
"STAT3"
],
"offsets": [
[
33,
38
]
],
"normalized": []
},
{
"id": "split_0_train_48989_entity",
"type": "progene_text",
"text": [
"AKT"
],
"offsets": [
[
52,
55
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30284 | split_0_train_30284 | [
{
"id": "split_0_train_30284_passage",
"type": "progene_text",
"text": [
"Both PDGF-BB and IL-4 induced STAT6 tyrosine phosphorylation , but the bands showed distinct electrophoretic migration patterns ."
],
"offsets": [
[
0,
129
]
]
}
] | [
{
"id": "split_0_train_48990_entity",
"type": "progene_text",
"text": [
"PDGF-BB"
],
"offsets": [
[
5,
12
]
],
"normalized": []
},
{
"id": "split_0_train_48991_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
17,
21
]
],
"normalized": []
},
{
"id": "split_0_train_48992_entity",
"type": "progene_text",
"text": [
"STAT6"
],
"offsets": [
[
30,
35
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30285 | split_0_train_30285 | [
{
"id": "split_0_train_30285_passage",
"type": "progene_text",
"text": [
"IL-4 alone and IL-4 added to the differentiation cocktail had no effect on adipocyte formation or PPARgamma expression ."
],
"offsets": [
[
0,
120
]
]
}
] | [
{
"id": "split_0_train_48993_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
0,
4
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],
"normalized": []
},
{
"id": "split_0_train_48994_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
15,
19
]
],
"normalized": []
},
{
"id": "split_0_train_48995_entity",
"type": "progene_text",
"text": [
"PPARgamma"
],
"offsets": [
[
98,
107
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30286 | split_0_train_30286 | [
{
"id": "split_0_train_30286_passage",
"type": "progene_text",
"text": [
"Collectively , these studies demonstrate that IL-4 inhibits PDGF-BB - induced preadipocyte proliferation , possibly through STAT6 activation ."
],
"offsets": [
[
0,
142
]
]
}
] | [
{
"id": "split_0_train_48996_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
46,
50
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],
"normalized": []
},
{
"id": "split_0_train_48997_entity",
"type": "progene_text",
"text": [
"PDGF-BB"
],
"offsets": [
[
60,
67
]
],
"normalized": []
},
{
"id": "split_0_train_48998_entity",
"type": "progene_text",
"text": [
"STAT6"
],
"offsets": [
[
124,
129
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30287 | split_0_train_30287 | [
{
"id": "split_0_train_30287_passage",
"type": "progene_text",
"text": [
"The pattern of IL-4 receptor expression suggests that the effects of IL-4 are targeted primarily towards preadipocytes ."
],
"offsets": [
[
0,
120
]
]
}
] | [
{
"id": "split_0_train_48999_entity",
"type": "progene_text",
"text": [
"IL-4 receptor"
],
"offsets": [
[
15,
28
]
],
"normalized": []
},
{
"id": "split_0_train_49000_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
69,
73
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30288 | split_0_train_30288 | [
{
"id": "split_0_train_30288_passage",
"type": "progene_text",
"text": [
"Application of AgaR repressor and dominant repressor variants for verification of a gene cluster involved in N-acetylgalactosamine metabolism in Escherichia coli K-12 ."
],
"offsets": [
[
0,
168
]
]
}
] | [
{
"id": "split_0_train_49001_entity",
"type": "progene_text",
"text": [
"AgaR"
],
"offsets": [
[
15,
19
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30289 | split_0_train_30289 | [
{
"id": "split_0_train_30289_passage",
"type": "progene_text",
"text": [
"The agaZVWEFASYBCDI gene cluster encodes the phosphotransferase systems and enzymes responsible for the uptake and metabolism of N-acetylgalactosamine and galactosamine in Escherichia coli ."
],
"offsets": [
[
0,
190
]
]
}
] | [
{
"id": "split_0_train_49002_entity",
"type": "progene_text",
"text": [
"agaZVWEFASYBCDI"
],
"offsets": [
[
4,
19
]
],
"normalized": []
},
{
"id": "split_0_train_49003_entity",
"type": "progene_text",
"text": [
"phosphotransferase systems"
],
"offsets": [
[
45,
71
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30290 | split_0_train_30290 | [
{
"id": "split_0_train_30290_passage",
"type": "progene_text",
"text": [
"In some strains of E. coli , particularly the common K-12 strain , a portion of this cluster is missing because of a site - specific recombination event that occurred between sites in agaW and agaA ."
],
"offsets": [
[
0,
199
]
]
}
] | [
{
"id": "split_0_train_49004_entity",
"type": "progene_text",
"text": [
"agaW"
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"offsets": [
[
184,
188
]
],
"normalized": []
},
{
"id": "split_0_train_49005_entity",
"type": "progene_text",
"text": [
"agaA"
],
"offsets": [
[
193,
197
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30291 | split_0_train_30291 | [
{
"id": "split_0_train_30291_passage",
"type": "progene_text",
"text": [
"Strains that have undergone this recombination event have lost the ability to utilize either N-acetylgalactosamine or galactosamine as sole sources of carbon ."
],
"offsets": [
[
0,
159
]
]
}
] | [] | [] | [] | [] |
split_0_train_30292 | split_0_train_30292 | [
{
"id": "split_0_train_30292_passage",
"type": "progene_text",
"text": [
"Divergently transcribed from this gene cluster is the gene agaR encoding a transcriptional repressor belonging to the DeoR / GlpR family of transcriptional regulators ."
],
"offsets": [
[
0,
168
]
]
}
] | [
{
"id": "split_0_train_49006_entity",
"type": "progene_text",
"text": [
"agaR"
],
"offsets": [
[
59,
63
]
],
"normalized": []
},
{
"id": "split_0_train_49007_entity",
"type": "progene_text",
"text": [
"DeoR / GlpR family"
],
"offsets": [
[
118,
136
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30293 | split_0_train_30293 | [
{
"id": "split_0_train_30293_passage",
"type": "progene_text",
"text": [
"Promoters upstream of agaR , agaZ and agaS were characterized ."
],
"offsets": [
[
0,
63
]
]
}
] | [
{
"id": "split_0_train_49008_entity",
"type": "progene_text",
"text": [
"agaR"
],
"offsets": [
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