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stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_30400 | split_0_train_30400 | [
{
"id": "split_0_train_30400_passage",
"type": "progene_text",
"text": [
"Activation of the receptor tyrosine kinase ErbB4 leads to various cellular responses such as proliferation , survival , differentiation , and chemotaxis ."
],
"offsets": [
[
0,
154
]
]
}
] | [
{
"id": "split_0_train_49262_entity",
"type": "progene_text",
"text": [
"receptor tyrosine kinase"
],
"offsets": [
[
18,
42
]
],
"normalized": []
},
{
"id": "split_0_train_49263_entity",
"type": "progene_text",
"text": [
"ErbB4"
],
"offsets": [
[
43,
48
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30401 | split_0_train_30401 | [
{
"id": "split_0_train_30401_passage",
"type": "progene_text",
"text": [
"Two pairs of naturally occurring ErbB4 isoforms differing in their juxtamembrane ( JMa / JMb ) and C termini ( cyt1 / cyt2 ) have been described ."
],
"offsets": [
[
0,
146
]
]
}
] | [
{
"id": "split_0_train_49264_entity",
"type": "progene_text",
"text": [
"ErbB4"
],
"offsets": [
[
33,
38
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30402 | split_0_train_30402 | [
{
"id": "split_0_train_30402_passage",
"type": "progene_text",
"text": [
"To examine the role of ErbB4 in neuron migration , we cloned and stably transfected each of the four ErbB4 isoforms in ST14A cells ( a neural progenitor cell line derived from the striatum of embryonic day 14 rats ) endogenously expressing the other members of the ErbB family : ErbB1 , ErbB2 , and ErbB3 ."
],
"offsets": [
[
0,
306
]
]
}
] | [
{
"id": "split_0_train_49265_entity",
"type": "progene_text",
"text": [
"ErbB4"
],
"offsets": [
[
23,
28
]
],
"normalized": []
},
{
"id": "split_0_train_49266_entity",
"type": "progene_text",
"text": [
"ErbB4"
],
"offsets": [
[
101,
106
]
],
"normalized": []
},
{
"id": "split_0_train_49267_entity",
"type": "progene_text",
"text": [
"ErbB family"
],
"offsets": [
[
265,
276
]
],
"normalized": []
},
{
"id": "split_0_train_49268_entity",
"type": "progene_text",
"text": [
"ErbB1"
],
"offsets": [
[
279,
284
]
],
"normalized": []
},
{
"id": "split_0_train_49269_entity",
"type": "progene_text",
"text": [
"ErbB2"
],
"offsets": [
[
287,
292
]
],
"normalized": []
},
{
"id": "split_0_train_49270_entity",
"type": "progene_text",
"text": [
"ErbB3"
],
"offsets": [
[
299,
304
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30403 | split_0_train_30403 | [
{
"id": "split_0_train_30403_passage",
"type": "progene_text",
"text": [
"Using immunoprecipitation assays , we showed that the neuregulin-1beta1 ( NRG1beta1 ) stimulus induced ErbB4 tyrosine phosphorylation and phosphatidylinositol 3-kinase ( PI3K ) recruitment and activation ( as demonstrated by Akt phosphorylation ) either directly ( ErbB4 cyt1 isoform ) or indirectly ( ErbB4 cyt2 isoform ) ."
],
"offsets": [
[
0,
324
]
]
}
] | [
{
"id": "split_0_train_49271_entity",
"type": "progene_text",
"text": [
"neuregulin-1beta1"
],
"offsets": [
[
54,
71
]
],
"normalized": []
},
{
"id": "split_0_train_49272_entity",
"type": "progene_text",
"text": [
"NRG1beta1"
],
"offsets": [
[
74,
83
]
],
"normalized": []
},
{
"id": "split_0_train_49273_entity",
"type": "progene_text",
"text": [
"ErbB4"
],
"offsets": [
[
103,
108
]
],
"normalized": []
},
{
"id": "split_0_train_49274_entity",
"type": "progene_text",
"text": [
"phosphatidylinositol 3-kinase"
],
"offsets": [
[
138,
167
]
],
"normalized": []
},
{
"id": "split_0_train_49275_entity",
"type": "progene_text",
"text": [
"PI3K"
],
"offsets": [
[
170,
174
]
],
"normalized": []
},
{
"id": "split_0_train_49276_entity",
"type": "progene_text",
"text": [
"Akt"
],
"offsets": [
[
225,
228
]
],
"normalized": []
},
{
"id": "split_0_train_49277_entity",
"type": "progene_text",
"text": [
"ErbB4"
],
"offsets": [
[
265,
270
]
],
"normalized": []
},
{
"id": "split_0_train_49278_entity",
"type": "progene_text",
"text": [
"ErbB4"
],
"offsets": [
[
302,
307
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30404 | split_0_train_30404 | [
{
"id": "split_0_train_30404_passage",
"type": "progene_text",
"text": [
"We examined the ability of the four ErbB4 isoforms to induce chemotaxis and cell proliferation in response to NRG1beta1 stimulation ."
],
"offsets": [
[
0,
133
]
]
}
] | [
{
"id": "split_0_train_49279_entity",
"type": "progene_text",
"text": [
"ErbB4"
],
"offsets": [
[
36,
41
]
],
"normalized": []
},
{
"id": "split_0_train_49280_entity",
"type": "progene_text",
"text": [
"NRG1beta1"
],
"offsets": [
[
110,
119
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30405 | split_0_train_30405 | [
{
"id": "split_0_train_30405_passage",
"type": "progene_text",
"text": [
"Using migration assays , we observed that only ErbB4 - expressing cells stimulated with NRG1beta1 showed a significant increase in migration , whereas the growth rate remained unchanged ."
],
"offsets": [
[
0,
187
]
]
}
] | [
{
"id": "split_0_train_49281_entity",
"type": "progene_text",
"text": [
"ErbB4"
],
"offsets": [
[
47,
52
]
],
"normalized": []
},
{
"id": "split_0_train_49282_entity",
"type": "progene_text",
"text": [
"NRG1beta1"
],
"offsets": [
[
88,
97
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30406 | split_0_train_30406 | [
{
"id": "split_0_train_30406_passage",
"type": "progene_text",
"text": [
"Additional assays showed that inhibition of PI3K ( but not of phospholipase Cgamma ) dramatically reduced migratory activity ."
],
"offsets": [
[
0,
126
]
]
}
] | [
{
"id": "split_0_train_49283_entity",
"type": "progene_text",
"text": [
"PI3K"
],
"offsets": [
[
44,
48
]
],
"normalized": []
},
{
"id": "split_0_train_49284_entity",
"type": "progene_text",
"text": [
"phospholipase Cgamma"
],
"offsets": [
[
62,
82
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30407 | split_0_train_30407 | [
{
"id": "split_0_train_30407_passage",
"type": "progene_text",
"text": [
"Our data show that ErbB4 signaling via PI3K activation plays a fundamental role in controlling NRG1beta1 - induced migration ."
],
"offsets": [
[
0,
126
]
]
}
] | [
{
"id": "split_0_train_49285_entity",
"type": "progene_text",
"text": [
"ErbB4"
],
"offsets": [
[
19,
24
]
],
"normalized": []
},
{
"id": "split_0_train_49286_entity",
"type": "progene_text",
"text": [
"PI3K"
],
"offsets": [
[
39,
43
]
],
"normalized": []
},
{
"id": "split_0_train_49287_entity",
"type": "progene_text",
"text": [
"NRG1beta1"
],
"offsets": [
[
95,
104
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30408 | split_0_train_30408 | [
{
"id": "split_0_train_30408_passage",
"type": "progene_text",
"text": [
"Enhancement of the antibody - dependent cellular cytotoxicity of low - fucose IgG1 Is independent of FcgammaRIIIa functional polymorphism ."
],
"offsets": [
[
0,
139
]
]
}
] | [
{
"id": "split_0_train_49288_entity",
"type": "progene_text",
"text": [
"IgG1"
],
"offsets": [
[
78,
82
]
],
"normalized": []
},
{
"id": "split_0_train_49289_entity",
"type": "progene_text",
"text": [
"FcgammaRIIIa"
],
"offsets": [
[
101,
113
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30409 | split_0_train_30409 | [
{
"id": "split_0_train_30409_passage",
"type": "progene_text",
"text": [
"PURPOSE :"
],
"offsets": [
[
0,
9
]
]
}
] | [] | [] | [] | [] |
split_0_train_30410 | split_0_train_30410 | [
{
"id": "split_0_train_30410_passage",
"type": "progene_text",
"text": [
"The most common polymorphic variant of Fcgamma receptor type IIIa ( FcgammaRIIIa ) , FcgammaRIIIa-158F , has been associated with inferior clinical responses to anti - CD20 chimeric IgG1 rituximab compared with FcgammaRIIIa-158V ."
],
"offsets": [
[
0,
230
]
]
}
] | [
{
"id": "split_0_train_49290_entity",
"type": "progene_text",
"text": [
"Fcgamma receptor type IIIa"
],
"offsets": [
[
39,
65
]
],
"normalized": []
},
{
"id": "split_0_train_49291_entity",
"type": "progene_text",
"text": [
"FcgammaRIIIa"
],
"offsets": [
[
68,
80
]
],
"normalized": []
},
{
"id": "split_0_train_49292_entity",
"type": "progene_text",
"text": [
"FcgammaRIIIa-158F"
],
"offsets": [
[
85,
102
]
],
"normalized": []
},
{
"id": "split_0_train_49293_entity",
"type": "progene_text",
"text": [
"CD20"
],
"offsets": [
[
168,
172
]
],
"normalized": []
},
{
"id": "split_0_train_49294_entity",
"type": "progene_text",
"text": [
"IgG1"
],
"offsets": [
[
182,
186
]
],
"normalized": []
},
{
"id": "split_0_train_49295_entity",
"type": "progene_text",
"text": [
"FcgammaRIIIa-158V"
],
"offsets": [
[
211,
228
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30411 | split_0_train_30411 | [
{
"id": "split_0_train_30411_passage",
"type": "progene_text",
"text": [
"As we previously found that removal of fucose residues from the oligosaccharides of human IgG1 results in enhanced antibody - dependent cellular cytotoxicity , we compared the effects of the FcgammaRIIIa gene ( FCGR3A ) polymorphism on normal and low - fucose versions of rituximab on antibody - dependent cellular cytotoxicity ."
],
"offsets": [
[
0,
329
]
]
}
] | [
{
"id": "split_0_train_49296_entity",
"type": "progene_text",
"text": [
"IgG1"
],
"offsets": [
[
90,
94
]
],
"normalized": []
},
{
"id": "split_0_train_49297_entity",
"type": "progene_text",
"text": [
"FcgammaRIIIa"
],
"offsets": [
[
191,
203
]
],
"normalized": []
},
{
"id": "split_0_train_49298_entity",
"type": "progene_text",
"text": [
"FCGR3A"
],
"offsets": [
[
211,
217
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30412 | split_0_train_30412 | [
{
"id": "split_0_train_30412_passage",
"type": "progene_text",
"text": [
"EXPERIMENTAL DESIGN :"
],
"offsets": [
[
0,
21
]
]
}
] | [] | [] | [] | [] |
split_0_train_30413 | split_0_train_30413 | [
{
"id": "split_0_train_30413_passage",
"type": "progene_text",
"text": [
"The polymorphism at position 158 of FcgammaRIIIa was determined for the peripheral blood mononuclear cells ( PBMCs ) of 20 healthy donors ."
],
"offsets": [
[
0,
139
]
]
}
] | [
{
"id": "split_0_train_49299_entity",
"type": "progene_text",
"text": [
"FcgammaRIIIa"
],
"offsets": [
[
36,
48
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30414 | split_0_train_30414 | [
{
"id": "split_0_train_30414_passage",
"type": "progene_text",
"text": [
"The PBMCs were then used as effector cells to compare the antibody - dependent cellular cytotoxicity of rituximab and a low - fucose version , KM3065 ."
],
"offsets": [
[
0,
151
]
]
}
] | [] | [] | [] | [] |
split_0_train_30415 | split_0_train_30415 | [
{
"id": "split_0_train_30415_passage",
"type": "progene_text",
"text": [
"The contributions of the different cell types within the PBMC to antibody - dependent cellular cytotoxicity were examined ."
],
"offsets": [
[
0,
123
]
]
}
] | [] | [] | [] | [] |
split_0_train_30416 | split_0_train_30416 | [
{
"id": "split_0_train_30416_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] | [] | [] | [] | [] |
split_0_train_30417 | split_0_train_30417 | [
{
"id": "split_0_train_30417_passage",
"type": "progene_text",
"text": [
"We found KM3065 - mediated antibody - dependent cellular cytotoxicity was increased 10 to 100 - fold compared with rituximab for each of the 20 donors ."
],
"offsets": [
[
0,
152
]
]
}
] | [] | [] | [] | [] |
split_0_train_30418 | split_0_train_30418 | [
{
"id": "split_0_train_30418_passage",
"type": "progene_text",
"text": [
"In contrast to rituximab , KM3065 antibody - dependent cellular cytotoxicity enhancement was similar for both FCGR3A alleles and thus independent of genotype ."
],
"offsets": [
[
0,
159
]
]
}
] | [
{
"id": "split_0_train_49300_entity",
"type": "progene_text",
"text": [
"FCGR3A"
],
"offsets": [
[
110,
116
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30419 | split_0_train_30419 | [
{
"id": "split_0_train_30419_passage",
"type": "progene_text",
"text": [
"In addition , antibody - dependent cellular cytotoxicity of both KM3065 and rituximab requires natural killer cells but not monocytes nor polymorphonuclear cells ."
],
"offsets": [
[
0,
163
]
]
}
] | [] | [] | [] | [] |
split_0_train_30420 | split_0_train_30420 | [
{
"id": "split_0_train_30420_passage",
"type": "progene_text",
"text": [
"The antibody - dependent cellular cytotoxicity ( ADCC ) of each of the 20 donors correlated with the natural killer cell numbers present in the PBMCs ."
],
"offsets": [
[
0,
151
]
]
}
] | [] | [] | [] | [] |
split_0_train_30421 | split_0_train_30421 | [
{
"id": "split_0_train_30421_passage",
"type": "progene_text",
"text": [
"Importantly , using KM3065 , the ADCC mediated by effector cells bearing the lower affinity variant FcgammaRIIIa-158F was significantly increased compared with rituximab - mediated ADCC using effector cells bearing the higher affinity FcgammaRIIIa-158V receptors ."
],
"offsets": [
[
0,
264
]
]
}
] | [
{
"id": "split_0_train_49301_entity",
"type": "progene_text",
"text": [
"FcgammaRIIIa-158F"
],
"offsets": [
[
100,
117
]
],
"normalized": []
},
{
"id": "split_0_train_49302_entity",
"type": "progene_text",
"text": [
"FcgammaRIIIa-158V"
],
"offsets": [
[
235,
252
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30422 | split_0_train_30422 | [
{
"id": "split_0_train_30422_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
] | [] | [] | [] | [] |
split_0_train_30423 | split_0_train_30423 | [
{
"id": "split_0_train_30423_passage",
"type": "progene_text",
"text": [
"The use of low - fucose antibodies might improve the therapeutic effects of anti - CD20 therapy for all patients independent of FcgammaRIIIa phenotype beyond that currently seen with even the most responsive patients ."
],
"offsets": [
[
0,
218
]
]
}
] | [
{
"id": "split_0_train_49303_entity",
"type": "progene_text",
"text": [
"CD20"
],
"offsets": [
[
83,
87
]
],
"normalized": []
},
{
"id": "split_0_train_49304_entity",
"type": "progene_text",
"text": [
"FcgammaRIIIa"
],
"offsets": [
[
128,
140
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30424 | split_0_train_30424 | [
{
"id": "split_0_train_30424_passage",
"type": "progene_text",
"text": [
"Cell division and cell survival in the absence of survivin ."
],
"offsets": [
[
0,
60
]
]
}
] | [
{
"id": "split_0_train_49305_entity",
"type": "progene_text",
"text": [
"survivin"
],
"offsets": [
[
50,
58
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30425 | split_0_train_30425 | [
{
"id": "split_0_train_30425_passage",
"type": "progene_text",
"text": [
"The survivin protein contains structural features of the inhibitor of apoptosis protein family ."
],
"offsets": [
[
0,
96
]
]
}
] | [
{
"id": "split_0_train_49306_entity",
"type": "progene_text",
"text": [
"survivin"
],
"offsets": [
[
4,
12
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30426 | split_0_train_30426 | [
{
"id": "split_0_train_30426_passage",
"type": "progene_text",
"text": [
"Previous studies have suggested that survivin is essential for cell survival because it counteracts an otherwise constitutive propensity to apoptosis during mitosis ."
],
"offsets": [
[
0,
166
]
]
}
] | [
{
"id": "split_0_train_49307_entity",
"type": "progene_text",
"text": [
"survivin"
],
"offsets": [
[
37,
45
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30427 | split_0_train_30427 | [
{
"id": "split_0_train_30427_passage",
"type": "progene_text",
"text": [
"In addition , survivin appears to be a component of the chromosomal passenger protein complex that participates in multiple facets of cell division ."
],
"offsets": [
[
0,
149
]
]
}
] | [
{
"id": "split_0_train_49308_entity",
"type": "progene_text",
"text": [
"survivin"
],
"offsets": [
[
14,
22
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30428 | split_0_train_30428 | [
{
"id": "split_0_train_30428_passage",
"type": "progene_text",
"text": [
"Here we report that euploid human cells do not die in the absence of survivin ."
],
"offsets": [
[
0,
79
]
]
}
] | [
{
"id": "split_0_train_49309_entity",
"type": "progene_text",
"text": [
"survivin"
],
"offsets": [
[
69,
77
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30429 | split_0_train_30429 | [
{
"id": "split_0_train_30429_passage",
"type": "progene_text",
"text": [
"Instead , depletion of survivin caused defects in cell division , followed by an arrest of DNA synthesis due to activation of a checkpoint involving the tumor suppressor protein p53 ."
],
"offsets": [
[
0,
183
]
]
}
] | [
{
"id": "split_0_train_49310_entity",
"type": "progene_text",
"text": [
"survivin"
],
"offsets": [
[
23,
31
]
],
"normalized": []
},
{
"id": "split_0_train_49311_entity",
"type": "progene_text",
"text": [
"tumor suppressor protein p53"
],
"offsets": [
[
153,
181
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30430 | split_0_train_30430 | [
{
"id": "split_0_train_30430_passage",
"type": "progene_text",
"text": [
"During anaphase mitosis in survivin - deficient cells , sister chromatids disjoined normally , but one or more of the sister chromatids frequently lagged behind the main mass of segregating chromosomes , probably because of merotelic kinetochore attachments ."
],
"offsets": [
[
0,
259
]
]
}
] | [
{
"id": "split_0_train_49312_entity",
"type": "progene_text",
"text": [
"survivin"
],
"offsets": [
[
27,
35
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30431 | split_0_train_30431 | [
{
"id": "split_0_train_30431_passage",
"type": "progene_text",
"text": [
"Survivin - deficient cells initiated but failed to complete cytokinesis , apparently because the spindle midzone and midbody microtublues were absent during late mitosis ."
],
"offsets": [
[
0,
171
]
]
}
] | [
{
"id": "split_0_train_49313_entity",
"type": "progene_text",
"text": [
"Survivin"
],
"offsets": [
[
0,
8
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30432 | split_0_train_30432 | [
{
"id": "split_0_train_30432_passage",
"type": "progene_text",
"text": [
"The abnormalities of both chromosome segregation and cytokinesis could be attributed to a defect in the chromosomal passenger protein complex , with a consequent mislocalization of the kinesin - like motor protein MKLP-1 playing a more immediate role in the microtubule abnormalities ."
],
"offsets": [
[
0,
285
]
]
}
] | [
{
"id": "split_0_train_49314_entity",
"type": "progene_text",
"text": [
"kinesin - like motor protein MKLP-1"
],
"offsets": [
[
185,
220
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30433 | split_0_train_30433 | [
{
"id": "split_0_train_30433_passage",
"type": "progene_text",
"text": [
"Depletion of another chromosomal passenger protein , aurora-B , recapitulated the survivin RNA interference phenotypes ."
],
"offsets": [
[
0,
120
]
]
}
] | [
{
"id": "split_0_train_49315_entity",
"type": "progene_text",
"text": [
"aurora-B"
],
"offsets": [
[
53,
61
]
],
"normalized": []
},
{
"id": "split_0_train_49316_entity",
"type": "progene_text",
"text": [
"survivin"
],
"offsets": [
[
82,
90
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30434 | split_0_train_30434 | [
{
"id": "split_0_train_30434_passage",
"type": "progene_text",
"text": [
"We conclude that survivin can be essential for the proliferation of normal human cells by virtue of its contributions to accurate sister chromatid segregation and assembly / stabilization of microtubules in late mitosis ."
],
"offsets": [
[
0,
221
]
]
}
] | [
{
"id": "split_0_train_49317_entity",
"type": "progene_text",
"text": [
"survivin"
],
"offsets": [
[
17,
25
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30435 | split_0_train_30435 | [
{
"id": "split_0_train_30435_passage",
"type": "progene_text",
"text": [
"However , the protein is not inevitably required for the survival of normal cells ."
],
"offsets": [
[
0,
83
]
]
}
] | [] | [] | [] | [] |
split_0_train_30436 | split_0_train_30436 | [
{
"id": "split_0_train_30436_passage",
"type": "progene_text",
"text": [
"ARIA , an Arabidopsis arm repeat protein interacting with a transcriptional regulator of abscisic acid - responsive gene expression , is a novel abscisic acid signaling component ."
],
"offsets": [
[
0,
180
]
]
}
] | [
{
"id": "split_0_train_49318_entity",
"type": "progene_text",
"text": [
"ARIA"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30437 | split_0_train_30437 | [
{
"id": "split_0_train_30437_passage",
"type": "progene_text",
"text": [
"Arabidopsis ( Arabidopsis thaliana ) genome contains more than 90 armadillo ( arm ) repeat proteins ."
],
"offsets": [
[
0,
101
]
]
}
] | [] | [] | [] | [] |
split_0_train_30438 | split_0_train_30438 | [
{
"id": "split_0_train_30438_passage",
"type": "progene_text",
"text": [
"However , their functions are largely unknown ."
],
"offsets": [
[
0,
47
]
]
}
] | [] | [] | [] | [] |
split_0_train_30439 | split_0_train_30439 | [
{
"id": "split_0_train_30439_passage",
"type": "progene_text",
"text": [
"Here , we report that an Arabidopsis arm repeat protein is involved in abscisic acid ( ABA ) response ."
],
"offsets": [
[
0,
103
]
]
}
] | [] | [] | [] | [] |
split_0_train_30440 | split_0_train_30440 | [
{
"id": "split_0_train_30440_passage",
"type": "progene_text",
"text": [
"We carried out two - hybrid screens to identify signaling components that modulate ABA - responsive gene expression ."
],
"offsets": [
[
0,
117
]
]
}
] | [] | [] | [] | [] |
split_0_train_30441 | split_0_train_30441 | [
{
"id": "split_0_train_30441_passage",
"type": "progene_text",
"text": [
"Employing a transcription factor , ABF2 , which controls the ABA - dependent gene expression via the G - box type ABA - responsive elements , we isolated an arm repeat protein ."
],
"offsets": [
[
0,
177
]
]
}
] | [
{
"id": "split_0_train_49319_entity",
"type": "progene_text",
"text": [
"transcription factor"
],
"offsets": [
[
12,
32
]
],
"normalized": []
},
{
"id": "split_0_train_49320_entity",
"type": "progene_text",
"text": [
"ABF2"
],
"offsets": [
[
35,
39
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30442 | split_0_train_30442 | [
{
"id": "split_0_train_30442_passage",
"type": "progene_text",
"text": [
"The ABF2 - interacting protein , designated as ARIA ( arm repeat protein interacting with ABF2 ) , has another conserved sequence motif , BTB / POZ ( broad complex , tramtrak , and bric-a-brac / poxvirus and zinc finger ) domain , in the C - terminal region ."
],
"offsets": [
[
0,
259
]
]
}
] | [
{
"id": "split_0_train_49321_entity",
"type": "progene_text",
"text": [
"ABF2"
],
"offsets": [
[
4,
8
]
],
"normalized": []
},
{
"id": "split_0_train_49322_entity",
"type": "progene_text",
"text": [
"ARIA"
],
"offsets": [
[
47,
51
]
],
"normalized": []
},
{
"id": "split_0_train_49323_entity",
"type": "progene_text",
"text": [
"arm repeat protein interacting with ABF2"
],
"offsets": [
[
54,
94
]
],
"normalized": []
},
{
"id": "split_0_train_49324_entity",
"type": "progene_text",
"text": [
"broad complex"
],
"offsets": [
[
150,
163
]
],
"normalized": []
},
{
"id": "split_0_train_49325_entity",
"type": "progene_text",
"text": [
"tramtrak"
],
"offsets": [
[
166,
174
]
],
"normalized": []
},
{
"id": "split_0_train_49326_entity",
"type": "progene_text",
"text": [
"bric-a-brac"
],
"offsets": [
[
181,
192
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30443 | split_0_train_30443 | [
{
"id": "split_0_train_30443_passage",
"type": "progene_text",
"text": [
"The physiological relevance of ABF2 - ARIA interaction was supported by their similar expression patterns and similar subcellular localization ."
],
"offsets": [
[
0,
144
]
]
}
] | [
{
"id": "split_0_train_49327_entity",
"type": "progene_text",
"text": [
"ABF2"
],
"offsets": [
[
31,
35
]
],
"normalized": []
},
{
"id": "split_0_train_49328_entity",
"type": "progene_text",
"text": [
"ARIA"
],
"offsets": [
[
38,
42
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30444 | split_0_train_30444 | [
{
"id": "split_0_train_30444_passage",
"type": "progene_text",
"text": [
"Plants overexpressing ARIA are hypersensitive to ABA and high osmolarity during germination and insensitive to salt during subsequent seedling growth ."
],
"offsets": [
[
0,
151
]
]
}
] | [
{
"id": "split_0_train_49329_entity",
"type": "progene_text",
"text": [
"ARIA"
],
"offsets": [
[
22,
26
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30445 | split_0_train_30445 | [
{
"id": "split_0_train_30445_passage",
"type": "progene_text",
"text": [
"By contrast , an ARIA knockout mutant exhibits ABA and glucose insensitivities ."
],
"offsets": [
[
0,
80
]
]
}
] | [
{
"id": "split_0_train_49330_entity",
"type": "progene_text",
"text": [
"ARIA"
],
"offsets": [
[
17,
21
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30446 | split_0_train_30446 | [
{
"id": "split_0_train_30446_passage",
"type": "progene_text",
"text": [
"Changes in the expression levels of several ABF2 - regulated genes were also observed in ARIA overexpression lines , indicating that ARIA modulates the transcriptional activity of ABF2 ."
],
"offsets": [
[
0,
186
]
]
}
] | [
{
"id": "split_0_train_49331_entity",
"type": "progene_text",
"text": [
"ABF2"
],
"offsets": [
[
44,
48
]
],
"normalized": []
},
{
"id": "split_0_train_49332_entity",
"type": "progene_text",
"text": [
"ARIA"
],
"offsets": [
[
89,
93
]
],
"normalized": []
},
{
"id": "split_0_train_49333_entity",
"type": "progene_text",
"text": [
"ARIA"
],
"offsets": [
[
133,
137
]
],
"normalized": []
},
{
"id": "split_0_train_49334_entity",
"type": "progene_text",
"text": [
"ABF2"
],
"offsets": [
[
180,
184
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30447 | split_0_train_30447 | [
{
"id": "split_0_train_30447_passage",
"type": "progene_text",
"text": [
"Together , our data indicate that ARIA is a positive regulator of ABA response ."
],
"offsets": [
[
0,
80
]
]
}
] | [
{
"id": "split_0_train_49335_entity",
"type": "progene_text",
"text": [
"ARIA"
],
"offsets": [
[
34,
38
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30448 | split_0_train_30448 | [
{
"id": "split_0_train_30448_passage",
"type": "progene_text",
"text": [
"Stimulation , monitoring , and analysis of pathway dynamics by metabolic profiling in the aromatic amino acid pathway ."
],
"offsets": [
[
0,
119
]
]
}
] | [] | [] | [] | [] |
split_0_train_30449 | split_0_train_30449 | [
{
"id": "split_0_train_30449_passage",
"type": "progene_text",
"text": [
"Using a concerted approach of biochemical standard preparation , analytical access via LC-MS / MS , glucose pulse , metabolic profiling , and statistical data analysis , the metabolism dynamics in the aromatic amino acid pathway has been stimulated , monitored , and analyzed in different tyrosine - auxotrophic L-phenylalanine-producing Escherichia coli strains ."
],
"offsets": [
[
0,
364
]
]
}
] | [] | [] | [] | [] |
split_0_train_30450 | split_0_train_30450 | [
{
"id": "split_0_train_30450_passage",
"type": "progene_text",
"text": [
"During the observation window from - 4 s ( before ) up to 27 s after the glucose pulse , the dynamics of the first five enzymatic reactions in the aromatic amino acid pathway was observed by measuring intracellular concentrations of 3-deoxy-d-arabino-heptulosonate 7-phosphate DAH(P) , 3-dehydroquinate ( 3-DHQ ) , 3-dehydroshikimate ( 3-DHS ) , shikimate 3-phosphate ( S3P ) , and shikimate ( SHI ) , together with the pathway precursors phosphoenolpyruvate ( PEP ) and P5P , the lumped pentose phosphate pool as an alternative to the nondetectable erythrose 4-phosphate ( E4P ) ."
],
"offsets": [
[
0,
581
]
]
}
] | [] | [] | [] | [] |
split_0_train_30451 | split_0_train_30451 | [
{
"id": "split_0_train_30451_passage",
"type": "progene_text",
"text": [
"Provided that a sufficient fortification of the carbon flux into the pathway of interest is ensured , respective metabolism dynamics can be observed ."
],
"offsets": [
[
0,
150
]
]
}
] | [] | [] | [] | [] |
split_0_train_30452 | split_0_train_30452 | [
{
"id": "split_0_train_30452_passage",
"type": "progene_text",
"text": [
"On the basis of the intracellular pool measurements , the standardized pool velocities were calculated , and a simple , data - driven criterion --called \" pool efflux capacity \" ( PEC ) -- is derived ."
],
"offsets": [
[
0,
201
]
]
}
] | [] | [] | [] | [] |
split_0_train_30453 | split_0_train_30453 | [
{
"id": "split_0_train_30453_passage",
"type": "progene_text",
"text": [
"Despite its simplifying system description , the criterion managed to identify the well - known AroB limitation in the E. coli strain A ( genotype delta ( pheA tyrA aroF ) / pJF119EH aroF ( fbr ) pheA ( fbr ) amp ) and it also succeeded to identify AroL and AroA ( in strain B , genotype delta ( pheA tyrA aroF ) / pJF119EH aroF ( fbr ) pheA ( fbr ) aroB amp ) as promising metabolic engineering targets to alleviate respective flux control in subsequent L-Phe producing strains ."
],
"offsets": [
[
0,
480
]
]
}
] | [
{
"id": "split_0_train_49336_entity",
"type": "progene_text",
"text": [
"AroB"
],
"offsets": [
[
96,
100
]
],
"normalized": []
},
{
"id": "split_0_train_49337_entity",
"type": "progene_text",
"text": [
"pheA"
],
"offsets": [
[
155,
159
]
],
"normalized": []
},
{
"id": "split_0_train_49338_entity",
"type": "progene_text",
"text": [
"tyrA"
],
"offsets": [
[
160,
164
]
],
"normalized": []
},
{
"id": "split_0_train_49339_entity",
"type": "progene_text",
"text": [
"aroF"
],
"offsets": [
[
165,
169
]
],
"normalized": []
},
{
"id": "split_0_train_49340_entity",
"type": "progene_text",
"text": [
"aroF"
],
"offsets": [
[
183,
187
]
],
"normalized": []
},
{
"id": "split_0_train_49341_entity",
"type": "progene_text",
"text": [
"pheA"
],
"offsets": [
[
196,
200
]
],
"normalized": []
},
{
"id": "split_0_train_49342_entity",
"type": "progene_text",
"text": [
"AroL"
],
"offsets": [
[
249,
253
]
],
"normalized": []
},
{
"id": "split_0_train_49343_entity",
"type": "progene_text",
"text": [
"AroA"
],
"offsets": [
[
258,
262
]
],
"normalized": []
},
{
"id": "split_0_train_49344_entity",
"type": "progene_text",
"text": [
"pheA"
],
"offsets": [
[
296,
300
]
],
"normalized": []
},
{
"id": "split_0_train_49345_entity",
"type": "progene_text",
"text": [
"tyrA"
],
"offsets": [
[
301,
305
]
],
"normalized": []
},
{
"id": "split_0_train_49346_entity",
"type": "progene_text",
"text": [
"aroF"
],
"offsets": [
[
306,
310
]
],
"normalized": []
},
{
"id": "split_0_train_49347_entity",
"type": "progene_text",
"text": [
"aroF"
],
"offsets": [
[
324,
328
]
],
"normalized": []
},
{
"id": "split_0_train_49348_entity",
"type": "progene_text",
"text": [
"pheA"
],
"offsets": [
[
337,
341
]
],
"normalized": []
},
{
"id": "split_0_train_49349_entity",
"type": "progene_text",
"text": [
"aroB"
],
"offsets": [
[
350,
354
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30454 | split_0_train_30454 | [
{
"id": "split_0_train_30454_passage",
"type": "progene_text",
"text": [
"Furthermore , using of a simple correlation analysis , the reconstruction of the metabolite sequence of the observed pathway was enabled ."
],
"offsets": [
[
0,
138
]
]
}
] | [] | [] | [] | [] |
split_0_train_30455 | split_0_train_30455 | [
{
"id": "split_0_train_30455_passage",
"type": "progene_text",
"text": [
"The results underline the necessity to extend the focus of glucose pulse experiments by studying not only the central metabolism but also anabolic pathways ."
],
"offsets": [
[
0,
157
]
]
}
] | [] | [] | [] | [] |
split_0_train_30456 | split_0_train_30456 | [
{
"id": "split_0_train_30456_passage",
"type": "progene_text",
"text": [
"Genetic diversity among A - proteins of atypical strains of Aeromonas salmonicida ."
],
"offsets": [
[
0,
83
]
]
}
] | [] | [] | [] | [] |
split_0_train_30457 | split_0_train_30457 | [
{
"id": "split_0_train_30457_passage",
"type": "progene_text",
"text": [
"The virulence array protein gene A ( vapA ) encoding the A - protein subunit of the surface layer of 23 typical and atypical strains of Aeromonas salmonicida from salmonids and marine fish species were sequenced , and the deduced A - protein sequences compared ."
],
"offsets": [
[
0,
262
]
]
}
] | [
{
"id": "split_0_train_49350_entity",
"type": "progene_text",
"text": [
"virulence array protein gene A"
],
"offsets": [
[
4,
34
]
],
"normalized": []
},
{
"id": "split_0_train_49351_entity",
"type": "progene_text",
"text": [
"vapA"
],
"offsets": [
[
37,
41
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30458 | split_0_train_30458 | [
{
"id": "split_0_train_30458_passage",
"type": "progene_text",
"text": [
"The A - proteins of the typical A. salmonicida ssp. salmonicida strains were shown to be identical , while amino acid variability was revealed among A - proteins of atypical strains ."
],
"offsets": [
[
0,
183
]
]
}
] | [] | [] | [] | [] |
split_0_train_30459 | split_0_train_30459 | [
{
"id": "split_0_train_30459_passage",
"type": "progene_text",
"text": [
"The highest amino acid variability appears to be in a predicted surface exposed region and is believed to result in antigenic differences among the atypical strains of A. salmonicida ."
],
"offsets": [
[
0,
184
]
]
}
] | [] | [] | [] | [] |
split_0_train_30460 | split_0_train_30460 | [
{
"id": "split_0_train_30460_passage",
"type": "progene_text",
"text": [
"The expression of intact and mutant human apoAI / CIII / AIV / AV gene cluster in transgenic mice ."
],
"offsets": [
[
0,
99
]
]
}
] | [
{
"id": "split_0_train_49352_entity",
"type": "progene_text",
"text": [
"apoAI / CIII / AIV / AV"
],
"offsets": [
[
42,
65
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30461 | split_0_train_30461 | [
{
"id": "split_0_train_30461_passage",
"type": "progene_text",
"text": [
"The apoAI / CIII / AIV gene cluster is involved in lipid metabolism and has a complex pattern of gene expression modulated by a common regulatory element , the apoCIII enhancer ."
],
"offsets": [
[
0,
178
]
]
}
] | [
{
"id": "split_0_train_49353_entity",
"type": "progene_text",
"text": [
"apoAI / CIII / AIV"
],
"offsets": [
[
4,
22
]
],
"normalized": []
},
{
"id": "split_0_train_49354_entity",
"type": "progene_text",
"text": [
"apoCIII"
],
"offsets": [
[
160,
167
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30462 | split_0_train_30462 | [
{
"id": "split_0_train_30462_passage",
"type": "progene_text",
"text": [
"A new member of this cluster , apolipoprotein ( apo ) AV , has recently been discovered as a novel modifier in triglyceride metabolism ."
],
"offsets": [
[
0,
136
]
]
}
] | [
{
"id": "split_0_train_49355_entity",
"type": "progene_text",
"text": [
"apolipoprotein ( apo ) AV"
],
"offsets": [
[
31,
56
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30463 | split_0_train_30463 | [
{
"id": "split_0_train_30463_passage",
"type": "progene_text",
"text": [
"To determine the expression of all four apo genes in combination and , most importantly , whether the transcription of apoAV is coregulated by the apoCIII enhancer in the cluster , we generated an intact transgenic line carrying the 116 - kb human apoAI / CIII / AIV / AV gene cluster and a mutant transgenic line in which the apoCIII enhancer was deleted from the 116 - kb structure ."
],
"offsets": [
[
0,
385
]
]
}
] | [
{
"id": "split_0_train_49356_entity",
"type": "progene_text",
"text": [
"apo"
],
"offsets": [
[
40,
43
]
],
"normalized": []
},
{
"id": "split_0_train_49357_entity",
"type": "progene_text",
"text": [
"apoAV"
],
"offsets": [
[
119,
124
]
],
"normalized": []
},
{
"id": "split_0_train_49358_entity",
"type": "progene_text",
"text": [
"apoCIII"
],
"offsets": [
[
147,
154
]
],
"normalized": []
},
{
"id": "split_0_train_49359_entity",
"type": "progene_text",
"text": [
"apoAI / CIII / AIV / AV"
],
"offsets": [
[
248,
271
]
],
"normalized": []
},
{
"id": "split_0_train_49360_entity",
"type": "progene_text",
"text": [
"apoCIII"
],
"offsets": [
[
327,
334
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30464 | split_0_train_30464 | [
{
"id": "split_0_train_30464_passage",
"type": "progene_text",
"text": [
"We demonstrated that the apoCIII enhancer regulated hepatic and intestinal apoAI , apoCIII , and apoAIV expression ; however , it did not direct the newly identified apoAV in the cluster ."
],
"offsets": [
[
0,
188
]
]
}
] | [
{
"id": "split_0_train_49361_entity",
"type": "progene_text",
"text": [
"apoCIII"
],
"offsets": [
[
25,
32
]
],
"normalized": []
},
{
"id": "split_0_train_49362_entity",
"type": "progene_text",
"text": [
"apoAI"
],
"offsets": [
[
75,
80
]
],
"normalized": []
},
{
"id": "split_0_train_49363_entity",
"type": "progene_text",
"text": [
"apoCIII"
],
"offsets": [
[
83,
90
]
],
"normalized": []
},
{
"id": "split_0_train_49364_entity",
"type": "progene_text",
"text": [
"apoAIV"
],
"offsets": [
[
97,
103
]
],
"normalized": []
},
{
"id": "split_0_train_49365_entity",
"type": "progene_text",
"text": [
"apoAV"
],
"offsets": [
[
166,
171
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30465 | split_0_train_30465 | [
{
"id": "split_0_train_30465_passage",
"type": "progene_text",
"text": [
"Furthermore , human apo genes displayed integrated position - independent expression and a closer approximation of copy number - dependent expression in the intact transgenic mice ."
],
"offsets": [
[
0,
181
]
]
}
] | [
{
"id": "split_0_train_49366_entity",
"type": "progene_text",
"text": [
"apo"
],
"offsets": [
[
20,
23
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30466 | split_0_train_30466 | [
{
"id": "split_0_train_30466_passage",
"type": "progene_text",
"text": [
"Because apoCIII and apoAV play opposite roles in triglyceride homeostasis , we analyzed the lipid profiles in our transgenic mice to assess the effects of human apoAI gene cluster expression on lipid metabolism ."
],
"offsets": [
[
0,
212
]
]
}
] | [
{
"id": "split_0_train_49367_entity",
"type": "progene_text",
"text": [
"apoCIII"
],
"offsets": [
[
8,
15
]
],
"normalized": []
},
{
"id": "split_0_train_49368_entity",
"type": "progene_text",
"text": [
"apoAV"
],
"offsets": [
[
20,
25
]
],
"normalized": []
},
{
"id": "split_0_train_49369_entity",
"type": "progene_text",
"text": [
"apoAI"
],
"offsets": [
[
161,
166
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30467 | split_0_train_30467 | [
{
"id": "split_0_train_30467_passage",
"type": "progene_text",
"text": [
"The triglyceride level was elevated in intact transgenic mice but decreased in mutant ones compared with nontransgenic mice ."
],
"offsets": [
[
0,
125
]
]
}
] | [] | [] | [] | [] |
split_0_train_30468 | split_0_train_30468 | [
{
"id": "split_0_train_30468_passage",
"type": "progene_text",
"text": [
"In addition , the expression of human apoAI and apoAIV elevated high density lipoprotein cholesterol in transgenic mice fed an atherogenic diet ."
],
"offsets": [
[
0,
145
]
]
}
] | [
{
"id": "split_0_train_49370_entity",
"type": "progene_text",
"text": [
"apoAI"
],
"offsets": [
[
38,
43
]
],
"normalized": []
},
{
"id": "split_0_train_49371_entity",
"type": "progene_text",
"text": [
"apoAIV"
],
"offsets": [
[
48,
54
]
],
"normalized": []
},
{
"id": "split_0_train_49372_entity",
"type": "progene_text",
"text": [
"high density lipoprotein"
],
"offsets": [
[
64,
88
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30469 | split_0_train_30469 | [
{
"id": "split_0_train_30469_passage",
"type": "progene_text",
"text": [
"In conclusion , our studies with human apoAI / CIII / AIV / AV gene cluster transgenic models showed that the apoCIII enhancer regulated expression of apoAI , apo - CIII , and apoAIV but not apoAV in vivo and showed the influences of expression of the entire cluster on lipid metabolism ."
],
"offsets": [
[
0,
288
]
]
}
] | [
{
"id": "split_0_train_49373_entity",
"type": "progene_text",
"text": [
"apoAI / CIII / AIV / AV"
],
"offsets": [
[
39,
62
]
],
"normalized": []
},
{
"id": "split_0_train_49374_entity",
"type": "progene_text",
"text": [
"apoCIII"
],
"offsets": [
[
110,
117
]
],
"normalized": []
},
{
"id": "split_0_train_49375_entity",
"type": "progene_text",
"text": [
"apoAI"
],
"offsets": [
[
151,
156
]
],
"normalized": []
},
{
"id": "split_0_train_49376_entity",
"type": "progene_text",
"text": [
"apo - CIII"
],
"offsets": [
[
159,
169
]
],
"normalized": []
},
{
"id": "split_0_train_49377_entity",
"type": "progene_text",
"text": [
"apoAIV"
],
"offsets": [
[
176,
182
]
],
"normalized": []
},
{
"id": "split_0_train_49378_entity",
"type": "progene_text",
"text": [
"apoAV"
],
"offsets": [
[
191,
196
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30470 | split_0_train_30470 | [
{
"id": "split_0_train_30470_passage",
"type": "progene_text",
"text": [
"Toll - like receptor 2 stimulation decreases IFN-gamma receptor expression in mouse RAW264.7 macrophages ."
],
"offsets": [
[
0,
106
]
]
}
] | [
{
"id": "split_0_train_49379_entity",
"type": "progene_text",
"text": [
"Toll - like receptor 2"
],
"offsets": [
[
0,
22
]
],
"normalized": []
},
{
"id": "split_0_train_49380_entity",
"type": "progene_text",
"text": [
"IFN-gamma receptor"
],
"offsets": [
[
45,
63
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30471 | split_0_train_30471 | [
{
"id": "split_0_train_30471_passage",
"type": "progene_text",
"text": [
"Interferon-gamma ( IFN-gamma ) is a key cytokine in the immune defense against mycobacteria ."
],
"offsets": [
[
0,
93
]
]
}
] | [
{
"id": "split_0_train_49381_entity",
"type": "progene_text",
"text": [
"Interferon-gamma"
],
"offsets": [
[
0,
16
]
],
"normalized": []
},
{
"id": "split_0_train_49382_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
19,
28
]
],
"normalized": []
},
{
"id": "split_0_train_49383_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
40,
48
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30472 | split_0_train_30472 | [
{
"id": "split_0_train_30472_passage",
"type": "progene_text",
"text": [
"IFN-gamma activates macrophages to resist the growth of mycobacteria and induces expression of MHC class II molecules required for antigen presentation ."
],
"offsets": [
[
0,
153
]
]
}
] | [
{
"id": "split_0_train_49384_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "split_0_train_49385_entity",
"type": "progene_text",
"text": [
"MHC class II"
],
"offsets": [
[
95,
107
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30473 | split_0_train_30473 | [
{
"id": "split_0_train_30473_passage",
"type": "progene_text",
"text": [
"Macrophages infected with mycobacteria or stimulated by the interaction of mycobacterial products with toll - like receptor 2 ( TLR2 ) have reduced responses to IFN-gamma ."
],
"offsets": [
[
0,
172
]
]
}
] | [
{
"id": "split_0_train_49386_entity",
"type": "progene_text",
"text": [
"toll - like receptor 2"
],
"offsets": [
[
103,
125
]
],
"normalized": []
},
{
"id": "split_0_train_49387_entity",
"type": "progene_text",
"text": [
"TLR2"
],
"offsets": [
[
128,
132
]
],
"normalized": []
},
{
"id": "split_0_train_49388_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
161,
170
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30474 | split_0_train_30474 | [
{
"id": "split_0_train_30474_passage",
"type": "progene_text",
"text": [
"Previous research has shown that infection of mouse macrophages with Mycobacterium avium causes decreased expression of the IFN-gamma receptor ( IFNGR ) ."
],
"offsets": [
[
0,
154
]
]
}
] | [
{
"id": "split_0_train_49389_entity",
"type": "progene_text",
"text": [
"IFN-gamma receptor"
],
"offsets": [
[
124,
142
]
],
"normalized": []
},
{
"id": "split_0_train_49390_entity",
"type": "progene_text",
"text": [
"IFNGR"
],
"offsets": [
[
145,
150
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30475 | split_0_train_30475 | [
{
"id": "split_0_train_30475_passage",
"type": "progene_text",
"text": [
"In the present study , we show that TLR2 stimulation of RAW264.7 macrophages with a synthetic lipoprotein , Pam3CSK4 , also causes rapid decrease in expression of IFNGR-1 protein , with little change in IFNGR-2 protein levels ."
],
"offsets": [
[
0,
227
]
]
}
] | [
{
"id": "split_0_train_49391_entity",
"type": "progene_text",
"text": [
"TLR2"
],
"offsets": [
[
36,
40
]
],
"normalized": []
},
{
"id": "split_0_train_49392_entity",
"type": "progene_text",
"text": [
"IFNGR-1"
],
"offsets": [
[
163,
170
]
],
"normalized": []
},
{
"id": "split_0_train_49393_entity",
"type": "progene_text",
"text": [
"IFNGR-2"
],
"offsets": [
[
203,
210
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30476 | split_0_train_30476 | [
{
"id": "split_0_train_30476_passage",
"type": "progene_text",
"text": [
"The decrease in IFNGR-2 expression in TLR2 - stimulated cells required receptor internalization and proteasomal degradation ."
],
"offsets": [
[
0,
125
]
]
}
] | [
{
"id": "split_0_train_49394_entity",
"type": "progene_text",
"text": [
"IFNGR-2"
],
"offsets": [
[
16,
23
]
],
"normalized": []
},
{
"id": "split_0_train_49395_entity",
"type": "progene_text",
"text": [
"TLR2"
],
"offsets": [
[
38,
42
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30477 | split_0_train_30477 | [
{
"id": "split_0_train_30477_passage",
"type": "progene_text",
"text": [
"The level of IFNGR-1 mRNA also decreased in TLR2 - stimulated RAW264.7 cells and M. avium - infected cells ."
],
"offsets": [
[
0,
108
]
]
}
] | [
{
"id": "split_0_train_49396_entity",
"type": "progene_text",
"text": [
"IFNGR-1"
],
"offsets": [
[
13,
20
]
],
"normalized": []
},
{
"id": "split_0_train_49397_entity",
"type": "progene_text",
"text": [
"TLR2"
],
"offsets": [
[
44,
48
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30478 | split_0_train_30478 | [
{
"id": "split_0_train_30478_passage",
"type": "progene_text",
"text": [
"The decrease in IFNGR-1 mRNA was shown to be due to decreased transcription ."
],
"offsets": [
[
0,
77
]
]
}
] | [
{
"id": "split_0_train_49398_entity",
"type": "progene_text",
"text": [
"IFNGR-1"
],
"offsets": [
[
16,
23
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30479 | split_0_train_30479 | [
{
"id": "split_0_train_30479_passage",
"type": "progene_text",
"text": [
"In spite of the decrease in IFNGR-2 receptor expression , activation of Stat1 activation by an optimal dose of IFN-gamma was identical between control and TLR2 - stimulated RAW264.7 cells ."
],
"offsets": [
[
0,
189
]
]
}
] | [
{
"id": "split_0_train_49399_entity",
"type": "progene_text",
"text": [
"IFNGR-2"
],
"offsets": [
[
28,
35
]
],
"normalized": []
},
{
"id": "split_0_train_49400_entity",
"type": "progene_text",
"text": [
"Stat1"
],
"offsets": [
[
72,
77
]
],
"normalized": []
},
{
"id": "split_0_train_49401_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
111,
120
]
],
"normalized": []
},
{
"id": "split_0_train_49402_entity",
"type": "progene_text",
"text": [
"TLR2"
],
"offsets": [
[
155,
159
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30480 | split_0_train_30480 | [
{
"id": "split_0_train_30480_passage",
"type": "progene_text",
"text": [
"However , at low suboptimal doses of IFN-gamma , Stat1 activation was decreased in TLR2 - stimulated cells ."
],
"offsets": [
[
0,
108
]
]
}
] | [
{
"id": "split_0_train_49403_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
37,
46
]
],
"normalized": []
},
{
"id": "split_0_train_49404_entity",
"type": "progene_text",
"text": [
"Stat1"
],
"offsets": [
[
49,
54
]
],
"normalized": []
},
{
"id": "split_0_train_49405_entity",
"type": "progene_text",
"text": [
"TLR2"
],
"offsets": [
[
83,
87
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30481 | split_0_train_30481 | [
{
"id": "split_0_train_30481_passage",
"type": "progene_text",
"text": [
"CpG ODNs treatments of HIV-1 infected patients may cause the decline of transmission in high risk populations - a review , hypothesis and implications ."
],
"offsets": [
[
0,
152
]
]
}
] | [] | [] | [] | [] |
split_0_train_30482 | split_0_train_30482 | [
{
"id": "split_0_train_30482_passage",
"type": "progene_text",
"text": [
"The Joint United Nations Program on HIV-1 / AIDS ( UNAIDS ) announced its goal to stop HIV-1 transmission by antiviral ( HAART ) treatment of patients since at the end of 2003 the number of people living with HIV - 1 was 38 million , 25 million in the sub - Saharan region of Africa ."
],
"offsets": [
[
0,
284
]
]
}
] | [] | [] | [] | [] |
split_0_train_30483 | split_0_train_30483 | [
{
"id": "split_0_train_30483_passage",
"type": "progene_text",
"text": [
"The present review deals with a new approach to simultaneously treat HIV-1 / AIDS patients in HIV-1 endemic regions with CpG oligodeoxynucleotides ( ODNs ) and people at high risk of infection with a vaccine containing CpG ODNs combined with synthetic HIV - 1 peptides by intranasal and intradermal applications.During HIV-1 infection a gradual increase in the levels of IL-4 and IgE in the patients ' serum , was reported ."
],
"offsets": [
[
0,
424
]
]
}
] | [
{
"id": "split_0_train_49406_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
371,
375
]
],
"normalized": []
},
{
"id": "split_0_train_49407_entity",
"type": "progene_text",
"text": [
"IgE"
],
"offsets": [
[
380,
383
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30484 | split_0_train_30484 | [
{
"id": "split_0_train_30484_passage",
"type": "progene_text",
"text": [
"It was suggested that such an increase of the cytokine IL-4 and the IgE immunoglobulin are interconnected and may serve as indicators for the coming stage of AIDS ."
],
"offsets": [
[
0,
164
]
]
}
] | [
{
"id": "split_0_train_49408_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
46,
54
]
],
"normalized": []
},
{
"id": "split_0_train_49409_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
55,
59
]
],
"normalized": []
},
{
"id": "split_0_train_49410_entity",
"type": "progene_text",
"text": [
"IgE"
],
"offsets": [
[
68,
71
]
],
"normalized": []
},
{
"id": "split_0_train_49411_entity",
"type": "progene_text",
"text": [
"immunoglobulin"
],
"offsets": [
[
72,
86
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30485 | split_0_train_30485 | [
{
"id": "split_0_train_30485_passage",
"type": "progene_text",
"text": [
"It was also suggested that the IL-4 and IgE increase in the serum of HIV-1 infected people resemble the increase of IL-4 and IgE levels in allergic patients that were exposed to endogenous or environmental allergens [ Becker , Virus Genes 28 , 5 - - 18 , 2004 ] ."
],
"offsets": [
[
0,
263
]
]
}
] | [
{
"id": "split_0_train_49412_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
31,
35
]
],
"normalized": []
},
{
"id": "split_0_train_49413_entity",
"type": "progene_text",
"text": [
"IgE"
],
"offsets": [
[
40,
43
]
],
"normalized": []
},
{
"id": "split_0_train_49414_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
116,
120
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],
"normalized": []
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] | [] | [] | [] |
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] | [] | [] | [] |
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{
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"text": [
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split_0_train_30489 | split_0_train_30489 | [
{
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}
] | [] | [] | [] | [] |
split_0_train_30490 | split_0_train_30490 | [
{
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"type": "progene_text",
"text": [
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split_0_train_30491 | split_0_train_30491 | [
{
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"type": "progene_text",
"text": [
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}
] | [] | [] | [] |
split_0_train_30492 | split_0_train_30492 | [
{
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"text": [
"It was also reported that treatment of mice with CpG ODN prior to or after retrovirus infections protected and cured , respectively , the retrovirus infection ."
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}
] | [] | [] | [] | [] |
split_0_train_30493 | split_0_train_30493 | [
{
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"type": "progene_text",
"text": [
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139
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}
] | [] | [] | [] | [] |
split_0_train_30494 | split_0_train_30494 | [
{
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"type": "progene_text",
"text": [
"Phase I treatment of healthy people with CpG ODNs provided information on the safety of these compounds ."
],
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0,
105
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}
] | [] | [] | [] | [] |
split_0_train_30495 | split_0_train_30495 | [
{
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"type": "progene_text",
"text": [
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] | [] | [] | [] |
split_0_train_30496 | split_0_train_30496 | [
{
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"type": "progene_text",
"text": [
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] | [] | [] | [] |
split_0_train_30497 | split_0_train_30497 | [
{
"id": "split_0_train_30497_passage",
"type": "progene_text",
"text": [
"CpG ODN-C contains motifs from CpG ODNs A and B and is more active.The present review is based on findings from studies that reported that CpG ODNs treatment of retrovirus infected mice , monkeys and allergic mice prevented the virus and allergens caused diseases , respectively ."
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]
}
] | [] | [] | [] | [] |
split_0_train_30498 | split_0_train_30498 | [
{
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"text": [
"Based on these studies , a hypothesis is presented that treatment of HIV - 1 infected and AIDS patients with CpG ODN-A and B or CpG ODN-C have the potential to inhibit IL-4 synthesis and release from FcrepsilonRI + hematopoietic cells by inducing TLR9 + pDCs to release large amounts of type I IFNs ."
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}
] | [] | [] | [] |
split_0_train_30499 | split_0_train_30499 | [
{
"id": "split_0_train_30499_passage",
"type": "progene_text",
"text": [
"TLR9 + B cells are induced by CpG ODN-B to switch from IgE to IgG , IgA synthesis ."
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}
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{
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] | [] | [] | [] |