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|---|---|---|---|---|---|---|
split_0_train_30600 | split_0_train_30600 | [
{
"id": "split_0_train_30600_passage",
"type": "progene_text",
"text": [
"A phenotype associated with genetic variation in ZNF202 is presently unknown ."
],
"offsets": [
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0,
78
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]
}
] | [
{
"id": "split_0_train_49636_entity",
"type": "progene_text",
"text": [
"ZNF202"
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"offsets": [
[
49,
55
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30601 | split_0_train_30601 | [
{
"id": "split_0_train_30601_passage",
"type": "progene_text",
"text": [
"We tested the hypothesis that a common variant in ZNF202 , A154V , predicts risk of ischemic heart disease ( IHD ) , myocardial infarction ( MI ) , and ischemic cerebrovascular disease ( ICVD ) ."
],
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[
0,
195
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}
] | [
{
"id": "split_0_train_49637_entity",
"type": "progene_text",
"text": [
"ZNF202"
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50,
56
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30602 | split_0_train_30602 | [
{
"id": "split_0_train_30602_passage",
"type": "progene_text",
"text": [
"METHODS AND RESULTS :"
],
"offsets": [
[
0,
21
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]
}
] | [] | [] | [] | [] |
split_0_train_30603 | split_0_train_30603 | [
{
"id": "split_0_train_30603_passage",
"type": "progene_text",
"text": [
"We conducted a prospective study of more than 9000 individuals from the general population with 24 years follow - up ."
],
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[
0,
118
]
]
}
] | [] | [] | [] | [] |
split_0_train_30604 | split_0_train_30604 | [
{
"id": "split_0_train_30604_passage",
"type": "progene_text",
"text": [
"In women , age - adjusted hazard ratios in heterozygotes and homozygotes versus non - carriers were 1.2 ( 95 % CI : 1.0 - 1.5 , P = 0.04 ) and 1.5 ( 1.1 - 2.1 , P = 0.007 ) for IHD , 1.5 ( 1.1 - 2.1 ; P = 0.01 ) and 1.7 ( 1.1 - 2.8 , P = 0.02 ) for MI , and 1.3 ( 1.0 - 1.8 , P = 0.07 ) and 1.3 ( 0.8 - 2.1 ; P = 0.33 ) for ICVD ."
],
"offsets": [
[
0,
330
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]
}
] | [] | [] | [] | [] |
split_0_train_30605 | split_0_train_30605 | [
{
"id": "split_0_train_30605_passage",
"type": "progene_text",
"text": [
"Adjustments for lipids and lipoproteins did not alter these hazard ratios substantially ."
],
"offsets": [
[
0,
89
]
]
}
] | [] | [] | [] | [] |
split_0_train_30606 | split_0_train_30606 | [
{
"id": "split_0_train_30606_passage",
"type": "progene_text",
"text": [
"Genotype did not predict risk in men ."
],
"offsets": [
[
0,
38
]
]
}
] | [] | [] | [] | [] |
split_0_train_30607 | split_0_train_30607 | [
{
"id": "split_0_train_30607_passage",
"type": "progene_text",
"text": [
"Finally , results for IHD were borderline significant ( P = 0.06 ) in an independent case - control study including 933 patients and 8068 controls ."
],
"offsets": [
[
0,
148
]
]
}
] | [] | [] | [] | [] |
split_0_train_30608 | split_0_train_30608 | [
{
"id": "split_0_train_30608_passage",
"type": "progene_text",
"text": [
"CONCLUSION :"
],
"offsets": [
[
0,
12
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]
}
] | [] | [] | [] | [] |
split_0_train_30609 | split_0_train_30609 | [
{
"id": "split_0_train_30609_passage",
"type": "progene_text",
"text": [
"This is the first study to suggest that ZNF202 could be a new candidate gene for IHD and MI in the general population ."
],
"offsets": [
[
0,
119
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]
}
] | [
{
"id": "split_0_train_49638_entity",
"type": "progene_text",
"text": [
"ZNF202"
],
"offsets": [
[
40,
46
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30610 | split_0_train_30610 | [
{
"id": "split_0_train_30610_passage",
"type": "progene_text",
"text": [
"Purinergic receptors in human placenta : evidence for functionally active P2X4 , P2X7 , P2Y2 , and P2Y6 ."
],
"offsets": [
[
0,
105
]
]
}
] | [
{
"id": "split_0_train_49639_entity",
"type": "progene_text",
"text": [
"Purinergic receptors"
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0,
20
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{
"id": "split_0_train_49640_entity",
"type": "progene_text",
"text": [
"P2X4"
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74,
78
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{
"id": "split_0_train_49641_entity",
"type": "progene_text",
"text": [
"P2X7"
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81,
85
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{
"id": "split_0_train_49642_entity",
"type": "progene_text",
"text": [
"P2Y2"
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88,
92
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{
"id": "split_0_train_49643_entity",
"type": "progene_text",
"text": [
"P2Y6"
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"offsets": [
[
99,
103
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30611 | split_0_train_30611 | [
{
"id": "split_0_train_30611_passage",
"type": "progene_text",
"text": [
"Appropriate regulation of ion transport by the human placental syncytiotrophoblast is important for fetal growth throughout pregnancy ."
],
"offsets": [
[
0,
135
]
]
}
] | [] | [] | [] | [] |
split_0_train_30612 | split_0_train_30612 | [
{
"id": "split_0_train_30612_passage",
"type": "progene_text",
"text": [
"In nonplacental tissues , ion transport can be modulated by extracellular nucleotides that raise intracellular calcium ( [ Ca2+ ] i ) via activation of purinergic receptors ."
],
"offsets": [
[
0,
174
]
]
}
] | [
{
"id": "split_0_train_49644_entity",
"type": "progene_text",
"text": [
"purinergic receptors"
],
"offsets": [
[
152,
172
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30613 | split_0_train_30613 | [
{
"id": "split_0_train_30613_passage",
"type": "progene_text",
"text": [
"We tested the hypothesis that purinergic receptors are expressed by human placental cytotrophoblast cells and that their activation by extracellular nucleotides modulates ion ( K+ ) efflux and [Ca2+ ] i ."
],
"offsets": [
[
0,
204
]
]
}
] | [
{
"id": "split_0_train_49645_entity",
"type": "progene_text",
"text": [
"purinergic receptors"
],
"offsets": [
[
30,
50
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30614 | split_0_train_30614 | [
{
"id": "split_0_train_30614_passage",
"type": "progene_text",
"text": [
"P2X / P2Y receptor agonists 5-bromouridine 5'-triphosphate ( 5-BrUTP ) , ADP , ATP , 2',3'-O-(4-benzoyl-benzoyl ) adenosine 5'-triphosphate ( BzATP ) , and UTP stimulated 86Rb ( K+ tracer ) efflux from cultured cytotrophoblast cells at early ( mononuclear ) or later ( multinucleate syncytiotrophoblast - like ) stages of differentiation , with ATP and UTP particularly potent ."
],
"offsets": [
[
0,
378
]
]
}
] | [
{
"id": "split_0_train_49646_entity",
"type": "progene_text",
"text": [
"P2X / P2Y receptor"
],
"offsets": [
[
0,
18
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30615 | split_0_train_30615 | [
{
"id": "split_0_train_30615_passage",
"type": "progene_text",
"text": [
"2-Methylthioadenosine 5'-triphosphate ( 2-MeS-ATP ) , and UDP elevated 86Rb efflux only from multinucleated cells ."
],
"offsets": [
[
0,
115
]
]
}
] | [] | [] | [] | [] |
split_0_train_30616 | split_0_train_30616 | [
{
"id": "split_0_train_30616_passage",
"type": "progene_text",
"text": [
"All agonists caused a significant peak and plateau increase in [Ca2+]i , although the magnitude of responses was variable ."
],
"offsets": [
[
0,
123
]
]
}
] | [] | [] | [] | [] |
split_0_train_30617 | split_0_train_30617 | [
{
"id": "split_0_train_30617_passage",
"type": "progene_text",
"text": [
"The effect of BzATP , UTP , and UDP in multinucleated cells was unaffected , and that of ATP partially inhibited , by removal of extracellular Ca2+ , implicating P2Y receptor activation ."
],
"offsets": [
[
0,
187
]
]
}
] | [
{
"id": "split_0_train_49647_entity",
"type": "progene_text",
"text": [
"P2Y receptor"
],
"offsets": [
[
162,
174
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30618 | split_0_train_30618 | [
{
"id": "split_0_train_30618_passage",
"type": "progene_text",
"text": [
"mRNA encoding P2X1 , P2X2 , P2X4 , and P2X7 and P2Y1 , P2Y2 , P2Y4 , P2Y6 , and P2Y11 were identified in mono - and multinucleated cells , whereas P2X3 and P2X5 mRNA were absent from all samples ."
],
"offsets": [
[
0,
196
]
]
}
] | [
{
"id": "split_0_train_49648_entity",
"type": "progene_text",
"text": [
"P2X1"
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[
14,
18
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},
{
"id": "split_0_train_49649_entity",
"type": "progene_text",
"text": [
"P2X2"
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[
21,
25
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],
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},
{
"id": "split_0_train_49650_entity",
"type": "progene_text",
"text": [
"P2X4"
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[
28,
32
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],
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},
{
"id": "split_0_train_49651_entity",
"type": "progene_text",
"text": [
"P2X7"
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39,
43
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{
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"P2Y1"
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48,
52
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{
"id": "split_0_train_49653_entity",
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"P2Y2"
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55,
59
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},
{
"id": "split_0_train_49654_entity",
"type": "progene_text",
"text": [
"P2Y4"
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62,
66
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],
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},
{
"id": "split_0_train_49655_entity",
"type": "progene_text",
"text": [
"P2Y6"
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69,
73
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],
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},
{
"id": "split_0_train_49656_entity",
"type": "progene_text",
"text": [
"P2Y11"
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80,
85
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},
{
"id": "split_0_train_49657_entity",
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"P2X3"
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147,
151
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{
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"P2X5"
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"offsets": [
[
156,
160
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30619 | split_0_train_30619 | [
{
"id": "split_0_train_30619_passage",
"type": "progene_text",
"text": [
"Western blot analysis revealed P2X4 , P2X7 , P2Y2 , and P2Y6 protein in cytotrophoblast cells , but P2Y4 was not detected ."
],
"offsets": [
[
0,
123
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]
}
] | [
{
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31,
35
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{
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"P2X7"
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38,
42
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{
"id": "split_0_train_49661_entity",
"type": "progene_text",
"text": [
"P2Y2"
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45,
49
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{
"id": "split_0_train_49662_entity",
"type": "progene_text",
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"P2Y6"
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56,
60
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{
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"type": "progene_text",
"text": [
"P2Y4"
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"offsets": [
[
100,
104
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30620 | split_0_train_30620 | [
{
"id": "split_0_train_30620_passage",
"type": "progene_text",
"text": [
"On the basis of published agonist selectivity , the data indicate the presence of functionally active P2X4 , P2X7 , P2Y2 , and P2Y6 receptors in cytotrophoblast cells ."
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"offsets": [
[
0,
168
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]
}
] | [
{
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"P2X4"
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102,
106
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{
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"text": [
"P2X7"
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109,
113
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{
"id": "split_0_train_49666_entity",
"type": "progene_text",
"text": [
"P2Y2"
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116,
120
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{
"id": "split_0_train_49667_entity",
"type": "progene_text",
"text": [
"P2Y6"
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"offsets": [
[
127,
131
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30621 | split_0_train_30621 | [
{
"id": "split_0_train_30621_passage",
"type": "progene_text",
"text": [
"We propose that activation of these receptors , and subsequent elevation of [Ca2+ ] i , modulates syncytiotrophoblast homeostasis and/or maternofetal ion exchange in response to extracellular nucleotides ."
],
"offsets": [
[
0,
205
]
]
}
] | [] | [] | [] | [] |
split_0_train_30622 | split_0_train_30622 | [
{
"id": "split_0_train_30622_passage",
"type": "progene_text",
"text": [
"The expansion of megakaryocyte progenitors from CD34 + - enriched mobilized peripheral blood stem cells is inhibited by Flt3 - L ."
],
"offsets": [
[
0,
130
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]
}
] | [
{
"id": "split_0_train_49668_entity",
"type": "progene_text",
"text": [
"CD34"
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48,
52
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{
"id": "split_0_train_49669_entity",
"type": "progene_text",
"text": [
"Flt3 - L"
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"offsets": [
[
120,
128
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30623 | split_0_train_30623 | [
{
"id": "split_0_train_30623_passage",
"type": "progene_text",
"text": [
"This study aimed to determine the optimal growth factor combination for expansion of megakaryocyte ( Mk ) progenitors with clonogenic potential from CD34 + - enriched mobilized peripheral blood stem cells ( PBSC ) ."
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"offsets": [
[
0,
215
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}
] | [
{
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"type": "progene_text",
"text": [
"growth factor"
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42,
55
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{
"id": "split_0_train_49671_entity",
"type": "progene_text",
"text": [
"CD34"
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"offsets": [
[
149,
153
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30624 | split_0_train_30624 | [
{
"id": "split_0_train_30624_passage",
"type": "progene_text",
"text": [
"Mobilized PBSC were monocyte depleted and CD34 + enriched , then cultured with various combinations of interleukin-3 ( IL-3 ) , IL-6 , IL-11 , Flt3 ligand ( Flt3-L ) , stem cell factor ( SCF ) , granulocyte - macrophage colonystimulating factor ( GM-CSF ) , and erythropoietin ( EPO ) , using a 2(7-3) IV fractional factorial design ."
],
"offsets": [
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0,
334
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}
] | [
{
"id": "split_0_train_49672_entity",
"type": "progene_text",
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"CD34"
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42,
46
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{
"id": "split_0_train_49673_entity",
"type": "progene_text",
"text": [
"interleukin-3"
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103,
116
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{
"id": "split_0_train_49674_entity",
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"text": [
"IL-3"
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119,
123
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{
"id": "split_0_train_49675_entity",
"type": "progene_text",
"text": [
"IL-6"
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128,
132
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{
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"IL-11"
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135,
140
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{
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"Flt3 ligand"
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143,
154
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{
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"Flt3-L"
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157,
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{
"id": "split_0_train_49679_entity",
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"stem cell factor"
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168,
184
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{
"id": "split_0_train_49680_entity",
"type": "progene_text",
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"SCF"
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187,
190
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{
"id": "split_0_train_49681_entity",
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"text": [
"granulocyte - macrophage colonystimulating factor"
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195,
244
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{
"id": "split_0_train_49682_entity",
"type": "progene_text",
"text": [
"GM-CSF"
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247,
253
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{
"id": "split_0_train_49683_entity",
"type": "progene_text",
"text": [
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262,
276
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{
"id": "split_0_train_49684_entity",
"type": "progene_text",
"text": [
"EPO"
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279,
282
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30625 | split_0_train_30625 | [
{
"id": "split_0_train_30625_passage",
"type": "progene_text",
"text": [
"Expansion of Mk committed progenitors ( CD41 + ) and primitive precursors ( CD61 + CD34 + ) was determined using FACS and colony - forming assays ."
],
"offsets": [
[
0,
147
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]
}
] | [
{
"id": "split_0_train_49685_entity",
"type": "progene_text",
"text": [
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40,
44
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{
"id": "split_0_train_49686_entity",
"type": "progene_text",
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"CD61"
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76,
80
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{
"id": "split_0_train_49687_entity",
"type": "progene_text",
"text": [
"CD34"
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"offsets": [
[
83,
87
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30626 | split_0_train_30626 | [
{
"id": "split_0_train_30626_passage",
"type": "progene_text",
"text": [
"Amplification of Mk progenitor production was attributed to IL-3 ( p < 0.002 ) , SCF ( p < 0.001 ) , and GM-CSF ( p < 0.05 ) ."
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0,
126
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split_0_train_30627 | split_0_train_30627 | [
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116,
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] | [] | [] | [] |
split_0_train_30628 | split_0_train_30628 | [
{
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137,
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] | [] | [] | [] |
split_0_train_30629 | split_0_train_30629 | [
{
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"text": [
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88,
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] | [] | [] | [] |
split_0_train_30630 | split_0_train_30630 | [
{
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"type": "progene_text",
"text": [
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132
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57,
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] | [] | [] | [] |
split_0_train_30631 | split_0_train_30631 | [
{
"id": "split_0_train_30631_passage",
"type": "progene_text",
"text": [
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{
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79,
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}
] | [] | [] | [] |
split_0_train_30632 | split_0_train_30632 | [
{
"id": "split_0_train_30632_passage",
"type": "progene_text",
"text": [
"Overexpression of claudin proteins in esophageal adenocarcinoma and its precursor lesions ."
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{
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"type": "progene_text",
"text": [
"claudin"
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18,
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"normalized": []
}
] | [] | [] | [] |
split_0_train_30633 | split_0_train_30633 | [
{
"id": "split_0_train_30633_passage",
"type": "progene_text",
"text": [
"Claudins are components of tight junctions important in intercellular barriers and cell polarity ."
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] | [
{
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"type": "progene_text",
"text": [
"Claudins"
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[
0,
8
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"normalized": []
}
] | [] | [] | [] |
split_0_train_30634 | split_0_train_30634 | [
{
"id": "split_0_train_30634_passage",
"type": "progene_text",
"text": [
"The authors identified upregulation of Claudins 3 , 4 , and 7 in gastric adenocarcinoma using Affymetrix U - 133 oligonucleotide microarrays and immunohistochemistry ( IHC ) ."
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] | [
{
"id": "split_0_train_49712_entity",
"type": "progene_text",
"text": [
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39,
61
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"normalized": []
}
] | [] | [] | [] |
split_0_train_30635 | split_0_train_30635 | [
{
"id": "split_0_train_30635_passage",
"type": "progene_text",
"text": [
"While normal gastric mucosa lacked Claudin 3 , 4 , and 7 expression , intestinal metaplasia and dysplasia showed these proteins ."
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129
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}
] | [
{
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"type": "progene_text",
"text": [
"Claudin 3 , 4 , and 7"
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35,
56
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30636 | split_0_train_30636 | [
{
"id": "split_0_train_30636_passage",
"type": "progene_text",
"text": [
"The authors hypothesized that Claudins would be similarly overexpressed in Barrett 's esophagus ( BE ) / adenocarcinoma ."
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121
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}
] | [
{
"id": "split_0_train_49714_entity",
"type": "progene_text",
"text": [
"Claudins"
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30,
38
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30637 | split_0_train_30637 | [
{
"id": "split_0_train_30637_passage",
"type": "progene_text",
"text": [
"Claudins 3 , 4 , and 7 gene expression was analyzed by Affymetrix U - 133 microarrays in three esophageal adenocarcinomas , one case of BE , and three normal esophagi ."
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168
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}
] | [
{
"id": "split_0_train_49715_entity",
"type": "progene_text",
"text": [
"Claudins 3 , 4 , and 7"
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0,
22
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"normalized": []
}
] | [] | [] | [] |
split_0_train_30638 | split_0_train_30638 | [
{
"id": "split_0_train_30638_passage",
"type": "progene_text",
"text": [
"IHC validation was performed using tissue microarrays constructed from esophageal resection specimens containing squamous ( 44 cases ) , gastric ( 40 cases ) , and non - dysplastic BE ( 16 cases ) , low - grade and high - grade dysplasia ( 16 and 26 cases ) , adenocarcinoma ( 58 cases ) , and nodal metastases ( 27 cases ) ."
],
"offsets": [
[
0,
325
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]
}
] | [] | [] | [] | [] |
split_0_train_30639 | split_0_train_30639 | [
{
"id": "split_0_train_30639_passage",
"type": "progene_text",
"text": [
"IHC staining was scored semiquantitatively ( 0 + to 4 + ) ."
],
"offsets": [
[
0,
59
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]
}
] | [] | [] | [] | [] |
split_0_train_30640 | split_0_train_30640 | [
{
"id": "split_0_train_30640_passage",
"type": "progene_text",
"text": [
"By microarray analysis , Claudin 3 showed a marked increase in mRNA expression compared with normal esophagus ( approximately 100 - fold ) ."
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"offsets": [
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0,
140
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}
] | [
{
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"type": "progene_text",
"text": [
"Claudin 3"
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"offsets": [
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25,
34
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"normalized": []
}
] | [] | [] | [] |
split_0_train_30641 | split_0_train_30641 | [
{
"id": "split_0_train_30641_passage",
"type": "progene_text",
"text": [
"Claudins 4 and 7 were modestly increased ( 2.2 - and 1.3 - fold ) ."
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0,
67
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}
] | [
{
"id": "split_0_train_49717_entity",
"type": "progene_text",
"text": [
"Claudins 4 and 7"
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"offsets": [
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0,
16
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"normalized": []
}
] | [] | [] | [] |
split_0_train_30642 | split_0_train_30642 | [
{
"id": "split_0_train_30642_passage",
"type": "progene_text",
"text": [
"By IHC , Claudin 3 expression was 1 + in most ( > 95 % ) normal squamous or gastric tissues and 2 + to 4 + in more than 80 % of high - grade dysplasia , adenocarcinoma , and metastases specimens ."
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196
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] | [
{
"id": "split_0_train_49718_entity",
"type": "progene_text",
"text": [
"Claudin 3"
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9,
18
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"normalized": []
}
] | [] | [] | [] |
split_0_train_30643 | split_0_train_30643 | [
{
"id": "split_0_train_30643_passage",
"type": "progene_text",
"text": [
"Claudin 4 protein expression was 2 + or less in most squamous and gastric mucosa ( > 90 % ) but 3 + or 4 + in BE , low - and high - grade dysplasia , adenocarcinoma , and metastases specimens ( > 90 % ) ."
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204
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}
] | [
{
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"type": "progene_text",
"text": [
"Claudin 4"
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0,
9
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"normalized": []
}
] | [] | [] | [] |
split_0_train_30644 | split_0_train_30644 | [
{
"id": "split_0_train_30644_passage",
"type": "progene_text",
"text": [
"Claudin 7 expression was minimal in squamous and gastric mucosa but strong ( 3 + to 4 + ) in BE and low - grade dysplasia ."
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123
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] | [
{
"id": "split_0_train_49720_entity",
"type": "progene_text",
"text": [
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0,
9
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"normalized": []
}
] | [] | [] | [] |
split_0_train_30645 | split_0_train_30645 | [
{
"id": "split_0_train_30645_passage",
"type": "progene_text",
"text": [
"In high - grade dysplasia , adenocarcinoma , and metastases , Claudin 7 was less intense , with 60 % to 70 % staining 3 + or 4 + and 30 % to 40 % staining weakly ( 1 + or 2 + ) ."
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178
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}
] | [
{
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62,
71
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}
] | [] | [] | [] |
split_0_train_30646 | split_0_train_30646 | [
{
"id": "split_0_train_30646_passage",
"type": "progene_text",
"text": [
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203
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{
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"text": [
"Claudin"
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41,
48
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}
] | [] | [] | [] |
split_0_train_30647 | split_0_train_30647 | [
{
"id": "split_0_train_30647_passage",
"type": "progene_text",
"text": [
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0,
134
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{
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"type": "progene_text",
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{
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"text": [
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50,
70
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}
] | [] | [] | [] |
split_0_train_30648 | split_0_train_30648 | [
{
"id": "split_0_train_30648_passage",
"type": "progene_text",
"text": [
"The continuous exposure of antimicrotubule drugs to tumors often results in the emergence of drug - resistant tumor cells with altered expression of several beta - tubulin isotypes ."
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182
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{
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157,
171
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}
] | [] | [] | [] |
split_0_train_30649 | split_0_train_30649 | [
{
"id": "split_0_train_30649_passage",
"type": "progene_text",
"text": [
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176
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{
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{
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84,
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{
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"type": "progene_text",
"text": [
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146,
166
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] | [] | [] | [] |
split_0_train_30650 | split_0_train_30650 | [
{
"id": "split_0_train_30650_passage",
"type": "progene_text",
"text": [
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132
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{
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"type": "progene_text",
"text": [
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48,
54
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"normalized": []
}
] | [] | [] | [] |
split_0_train_30651 | split_0_train_30651 | [
{
"id": "split_0_train_30651_passage",
"type": "progene_text",
"text": [
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224
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{
"id": "split_0_train_49730_entity",
"type": "progene_text",
"text": [
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{
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"type": "progene_text",
"text": [
"mTUBB2"
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"offsets": [
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205,
211
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"normalized": []
}
] | [] | [] | [] |
split_0_train_30652 | split_0_train_30652 | [
{
"id": "split_0_train_30652_passage",
"type": "progene_text",
"text": [
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163
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] | [
{
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"text": [
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128,
131
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}
] | [] | [] | [] |
split_0_train_30653 | split_0_train_30653 | [
{
"id": "split_0_train_30653_passage",
"type": "progene_text",
"text": [
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137
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{
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{
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{
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{
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"type": "progene_text",
"text": [
"mTUBB2"
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118,
124
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}
] | [] | [] | [] |
split_0_train_30654 | split_0_train_30654 | [
{
"id": "split_0_train_30654_passage",
"type": "progene_text",
"text": [
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181
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{
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{
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{
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162,
168
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] | [] | [] | [] |
split_0_train_30655 | split_0_train_30655 | [
{
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"This phenomenon could be related with the emergence of drug - resistant tumor cells induced by Vinca alkaloid and may participate in determining the fate of these cells ."
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] | [] | [] | [] | [] |
split_0_train_30656 | split_0_train_30656 | [
{
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"text": [
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98,
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] | [] | [] | [] |
split_0_train_30657 | split_0_train_30657 | [
{
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"text": [
"Biometals play an important role in Alzheimer disease , and recent reports have described the development of potential therapeutic agents based on modulation of metal bioavailability ."
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] | [] | [] | [] | [] |
split_0_train_30658 | split_0_train_30658 | [
{
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"text": [
"The metal ligand clioquinol ( CQ ) has shown promising results in animal models and small phase clinical trials ; however , the actual mode of action in vivo has not been determined ."
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] | [] | [] | [] | [] |
split_0_train_30659 | split_0_train_30659 | [
{
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"text": [
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] | [] | [] | [] |
split_0_train_30660 | split_0_train_30660 | [
{
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"text": [
"Treatment of Chinese hamster ovary cells overexpressing amyloid precursor protein with CQ and Cu(2+) or Zn ( 2 + ) resulted in an approximately 85 - 90 % reduction of secreted Abeta - ( 1 - 40 ) and Abeta - ( 1 - 42 ) compared with untreated controls ."
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199,
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}
] | [] | [] | [] |
split_0_train_30661 | split_0_train_30661 | [
{
"id": "split_0_train_30661_passage",
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"text": [
"Analogous effects were seen in amyloid precursor protein - overexpressing neuroblastoma cells ."
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] | [] | [] | [] |
split_0_train_30662 | split_0_train_30662 | [
{
"id": "split_0_train_30662_passage",
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"text": [
"The secreted Abeta was rapidly degraded through up - regulation of matrix metalloprotease ( MMP ) - 2 and MMP-3 after addition of CQ and Cu(2+) ."
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106,
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}
] | [] | [] | [] |
split_0_train_30663 | split_0_train_30663 | [
{
"id": "split_0_train_30663_passage",
"type": "progene_text",
"text": [
"MMP activity was increased through activation of phosphoinositol 3-kinase and JNK ."
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"text": [
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78,
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}
] | [] | [] | [] |
split_0_train_30664 | split_0_train_30664 | [
{
"id": "split_0_train_30664_passage",
"type": "progene_text",
"text": [
"CQ and Cu(2+) also promoted phosphorylation of glycogen synthase kinase - 3 , and this potentiated activation of JNK and loss of Abeta - ( 1 - 40 ) ."
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149
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{
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113,
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"text": [
"Abeta"
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129,
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],
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}
] | [] | [] | [] |
split_0_train_30665 | split_0_train_30665 | [
{
"id": "split_0_train_30665_passage",
"type": "progene_text",
"text": [
"Our findings identify an alternative mechanism of action for CQ in the reduction of Abeta deposition in the brains of CQ - treated animals and potentially in Alzheimer disease patients ."
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{
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84,
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}
] | [] | [] | [] |
split_0_train_30666 | split_0_train_30666 | [
{
"id": "split_0_train_30666_passage",
"type": "progene_text",
"text": [
"Facilitation of survival in a rat fulminant hepatic failure model by combination therapy using recombinant G-CSF and tacrolimus ."
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129
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] | [
{
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"text": [
"G-CSF"
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107,
112
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}
] | [] | [] | [] |
split_0_train_30667 | split_0_train_30667 | [
{
"id": "split_0_train_30667_passage",
"type": "progene_text",
"text": [
"The mortality rate of fulminant hepatic failure ( FHF ) is high because of retarded liver regeneration ."
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0,
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]
}
] | [] | [] | [] | [] |
split_0_train_30668 | split_0_train_30668 | [
{
"id": "split_0_train_30668_passage",
"type": "progene_text",
"text": [
"Recombinant human granulocyte colony - stimulating factor ( rHuG-CSF ) and tacrolimus are known to be immunosuppressive and supportive to liver regeneration ."
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158
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]
}
] | [
{
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{
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"type": "progene_text",
"text": [
"rHuG-CSF"
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60,
68
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],
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}
] | [] | [] | [] |
split_0_train_30669 | split_0_train_30669 | [
{
"id": "split_0_train_30669_passage",
"type": "progene_text",
"text": [
"We investigated the effects of their combination therapy in a rat FHF model with a 68 % partial hepatectomy and 24 % liver necrosis ."
],
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[
0,
133
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]
}
] | [] | [] | [] | [] |
split_0_train_30670 | split_0_train_30670 | [
{
"id": "split_0_train_30670_passage",
"type": "progene_text",
"text": [
"All rats without drug pretreatment died within 55 h ."
],
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0,
53
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]
}
] | [] | [] | [] | [] |
split_0_train_30671 | split_0_train_30671 | [
{
"id": "split_0_train_30671_passage",
"type": "progene_text",
"text": [
"The median time was prolonged from 37 to 52 h by rHuG-CSF ( 250 microg / kg / day s.c. on days - 5 to 0 ) and to 46 h by tacrolimus ( 0.5 mg / kg / day i.m. on days - 2 to 0 ) ."
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177
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}
] | [
{
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49,
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}
] | [] | [] | [] |
split_0_train_30672 | split_0_train_30672 | [
{
"id": "split_0_train_30672_passage",
"type": "progene_text",
"text": [
"Notably , the combination therapy facilitated DNA biosynthesis and survival prolongation , with a median of 77 h ."
],
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[
0,
114
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]
}
] | [] | [] | [] | [] |
split_0_train_30673 | split_0_train_30673 | [
{
"id": "split_0_train_30673_passage",
"type": "progene_text",
"text": [
"The interferon-gamma ( IFN-gamma ) protein levels and natural killer cell ( NK ) activity in the liver were low at 12 h , and no further inhibition was detected by any treatment ."
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0,
179
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]
}
] | [
{
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23,
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}
] | [] | [] | [] |
split_0_train_30674 | split_0_train_30674 | [
{
"id": "split_0_train_30674_passage",
"type": "progene_text",
"text": [
"Tacrolimus significantly upregulated the mRNA levels of insulin receptors and transforming growth factor - alpha ( TGF-alpha ) , whereas rHuG-CSF did not ."
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155
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] | [
{
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{
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78,
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{
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115,
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{
"id": "split_0_train_49768_entity",
"type": "progene_text",
"text": [
"rHuG-CSF"
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137,
145
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],
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}
] | [] | [] | [] |
split_0_train_30675 | split_0_train_30675 | [
{
"id": "split_0_train_30675_passage",
"type": "progene_text",
"text": [
"Regarding tissue remodeling - related factors , rHuG-CSF upregulated mRNA levels of vascular endothelial growth factor ( VEGF ) and matrix metalloproteinase - 9 ( MMP-9 ) , whereas tacrolimus did not ."
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0,
201
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]
}
] | [
{
"id": "split_0_train_49769_entity",
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48,
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{
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{
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121,
125
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{
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132,
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{
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"text": [
"MMP-9"
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163,
168
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],
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}
] | [] | [] | [] |
split_0_train_30676 | split_0_train_30676 | [
{
"id": "split_0_train_30676_passage",
"type": "progene_text",
"text": [
"The combination treatment upregulated protein levels of both insulin receptors and VEGF ."
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0,
89
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}
] | [
{
"id": "split_0_train_49774_entity",
"type": "progene_text",
"text": [
"VEGF"
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83,
87
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],
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}
] | [] | [] | [] |
split_0_train_30677 | split_0_train_30677 | [
{
"id": "split_0_train_30677_passage",
"type": "progene_text",
"text": [
"These results suggest that tacrolimus improves the hepatocyte replication and rHuG-CSF contributes to tissue reconstitution , and this combination therapy directly facilitates liver regeneration in the FHF model ."
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[
0,
213
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]
}
] | [
{
"id": "split_0_train_49775_entity",
"type": "progene_text",
"text": [
"rHuG-CSF"
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78,
86
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],
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}
] | [] | [] | [] |
split_0_train_30678 | split_0_train_30678 | [
{
"id": "split_0_train_30678_passage",
"type": "progene_text",
"text": [
"The role of the STAS domain in the function and biogenesis of a sulfate transporter as probed by random mutagenesis ."
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0,
117
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}
] | [
{
"id": "split_0_train_49776_entity",
"type": "progene_text",
"text": [
"sulfate transporter"
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64,
83
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],
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}
] | [] | [] | [] |
split_0_train_30679 | split_0_train_30679 | [
{
"id": "split_0_train_30679_passage",
"type": "progene_text",
"text": [
"Sulfate transporters in plants represent a family of proteins containing transmembrane domains that constitute the catalytic part of the protein and a short linking region that joins this catalytic moiety with a C - terminal STAS domain ."
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0,
238
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}
] | [
{
"id": "split_0_train_49777_entity",
"type": "progene_text",
"text": [
"Sulfate transporters"
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20
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}
] | [] | [] | [] |
split_0_train_30680 | split_0_train_30680 | [
{
"id": "split_0_train_30680_passage",
"type": "progene_text",
"text": [
"The STAS domain resembles an anti - sigma factor antagonist of Bacillus subtilis , which is one distinguishing feature of the SLC26 transporter family ; this family includes transporters for sulfate and other anions such as iodide and carbonate ."
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"offsets": [
[
0,
246
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}
] | [
{
"id": "split_0_train_49778_entity",
"type": "progene_text",
"text": [
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29,
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{
"id": "split_0_train_49779_entity",
"type": "progene_text",
"text": [
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[
126,
150
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30681 | split_0_train_30681 | [
{
"id": "split_0_train_30681_passage",
"type": "progene_text",
"text": [
"Recent work has demonstrated that this domain is critical for the activity of Arabidopsis thaliana sulfate transporters , and specific lesions in this domain , or the exchange of STAS domains between different sulfate transporters , can severely impair transport activity ."
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"offsets": [
[
0,
273
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]
}
] | [
{
"id": "split_0_train_49780_entity",
"type": "progene_text",
"text": [
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99,
119
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{
"id": "split_0_train_49781_entity",
"type": "progene_text",
"text": [
"sulfate transporters"
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[
210,
230
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30682 | split_0_train_30682 | [
{
"id": "split_0_train_30682_passage",
"type": "progene_text",
"text": [
"In this work we generated a Saccharomyces cerevisiae expression library of the A. thaliana Sultr1 ; 2 gene with random mutations in the linking region - STAS domain and identified STAS domain lesions that altered Sultr1 ; 2 biogenesis and/or function ."
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"offsets": [
[
0,
252
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]
}
] | [
{
"id": "split_0_train_49782_entity",
"type": "progene_text",
"text": [
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91,
101
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{
"id": "split_0_train_49783_entity",
"type": "progene_text",
"text": [
"Sultr1 ; 2"
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"offsets": [
[
213,
223
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30683 | split_0_train_30683 | [
{
"id": "split_0_train_30683_passage",
"type": "progene_text",
"text": [
"A number of mutations in the beta-sheet that forms the core of the STAS domain prevented intracellular accumulation of Sultr1 ; 2 ."
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[
0,
131
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]
}
] | [
{
"id": "split_0_train_49784_entity",
"type": "progene_text",
"text": [
"Sultr1 ; 2"
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"offsets": [
[
119,
129
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_30684 | split_0_train_30684 | [
{
"id": "split_0_train_30684_passage",
"type": "progene_text",
"text": [
"In contrast , the linking region and one surface of the STAS domain containing N termini of the first and second alpha-helices have a number of amino acids critical for the function of the protein ; mutations in these regions still allow protein accumulation in the plasma membrane , but the protein is no longer capable of efficiently transporting sulfate into cells ."
],
"offsets": [
[
0,
369
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]
}
] | [] | [] | [] | [] |
split_0_train_30685 | split_0_train_30685 | [
{
"id": "split_0_train_30685_passage",
"type": "progene_text",
"text": [
"These results suggest that the STAS domain is critical for both the activity and biosynthesis / stability of the transporter , and that STAS sub - domains correlate with these specific functions ."
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[
0,
196
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]
}
] | [] | [] | [] | [] |
split_0_train_30686 | split_0_train_30686 | [
{
"id": "split_0_train_30686_passage",
"type": "progene_text",
"text": [
"Coassociation of CD26 ( dipeptidyl peptidase IV ) with CD45 on the surface of human T lymphocytes ."
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[
0,
99
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]
}
] | [
{
"id": "split_0_train_49785_entity",
"type": "progene_text",
"text": [
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17,
21
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{
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"type": "progene_text",
"text": [
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split_0_train_30688 | split_0_train_30688 | [
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"text": [
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split_0_train_30690 | split_0_train_30690 | [
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"text": [
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] | [] | [] | [] |
split_0_train_30691 | split_0_train_30691 | [
{
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split_0_train_30692 | split_0_train_30692 | [
{
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"text": [
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186,
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}
] | [] | [] | [] |
split_0_train_30693 | split_0_train_30693 | [
{
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"text": [
"Analysis of the cellular trafficking of these two chimeras demonstrated that both molecules colocalized with MHC class II molecules but differed in their overall trafficking to endosomal / lysosomal compartments ."
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] | [] | [] | [] |
split_0_train_30694 | split_0_train_30694 | [
{
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"text": [
"Following DNA immunization , both chimeras elicited potent Gag - specific T and B cell immune responses in mice but differ markedly in their IL-4 and IgG1 / IgG2a responses ."
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174
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157,
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}
] | [] | [] | [] |
split_0_train_30695 | split_0_train_30695 | [
{
"id": "split_0_train_30695_passage",
"type": "progene_text",
"text": [
"The DC - LAMP chimera induced a stronger Th type 1 response ."
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61
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}
] | [
{
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}
] | [] | [] | [] |
split_0_train_30696 | split_0_train_30696 | [
{
"id": "split_0_train_30696_passage",
"type": "progene_text",
"text": [
"ELISPOT analysis of T cell responses to 122 individual peptides encompassing the entire p55gag sequence ( 15-aa peptides overlapping by 11 residues ) showed that DNA immunization with native gag , LAMP / gag , or DC - LAMP / gag induced responses to identical immunodominant CD4 + and CD8 + peptides ."
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285,
288
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],
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}
] | [] | [] | [] |
split_0_train_30697 | split_0_train_30697 | [
{
"id": "split_0_train_30697_passage",
"type": "progene_text",
"text": [
"However , LAMP / gag and DC - LAMP / gag plasmids also elicited significant responses to 23 additional cryptic epitopes that were not recognized after immunization with native gag DNA ."
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0,
185
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}
] | [
{
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{
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176,
179
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}
] | [] | [] | [] |
split_0_train_30698 | split_0_train_30698 | [
{
"id": "split_0_train_30698_passage",
"type": "progene_text",
"text": [
"The three plasmids induced T cell responses to a total of 39 distinct peptide sequences , 13 of which were induced by all three DNA constructs ."
],
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[
0,
144
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]
}
] | [] | [] | [] | [] |
split_0_train_30699 | split_0_train_30699 | [
{
"id": "split_0_train_30699_passage",
"type": "progene_text",
"text": [
"Individually , DC - LAMP / gag elicited the most diverse response , with a specific T cell response against 35 peptides ."
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"offsets": [
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0,
121
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]
}
] | [
{
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{
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27,
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] | [] | [] | [] |