id
stringlengths
15
19
document_id
stringlengths
15
19
passages
list
entities
list
events
list
coreferences
list
relations
list
split_0_train_30700
split_0_train_30700
[ { "id": "split_0_train_30700_passage", "type": "progene_text", "text": [ "In addition , immunization with LAMP / gag and DC - LAMP / gag chimeras also promoted Ab secretion to an increased number of epitopes ." ], "offsets": [ [ 0, 135 ] ] } ]
[ { "id": "split_0_train_49837_entity", "type": "progene_text", "text": [ "LAMP" ], "offsets": [ [ 32, 36 ] ], "normalized": [] }, { "id": "split_0_train_49838_entity", "type": "progene_text", "text": [ "gag" ], "offsets": [ [ 39, 42 ] ], "normalized": [] }, { "id": "split_0_train_49839_entity", "type": "progene_text", "text": [ "DC - LAMP" ], "offsets": [ [ 47, 56 ] ], "normalized": [] }, { "id": "split_0_train_49840_entity", "type": "progene_text", "text": [ "gag" ], "offsets": [ [ 59, 62 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30701
split_0_train_30701
[ { "id": "split_0_train_30701_passage", "type": "progene_text", "text": [ "These data indicate that LAMP-1 and DC - LAMP Ag chimeras follow different trafficking pathways , induce distinct modulatory immune responses , and are able to present cryptic epitopes ." ], "offsets": [ [ 0, 186 ] ] } ]
[ { "id": "split_0_train_49841_entity", "type": "progene_text", "text": [ "LAMP-1" ], "offsets": [ [ 25, 31 ] ], "normalized": [] }, { "id": "split_0_train_49842_entity", "type": "progene_text", "text": [ "DC - LAMP" ], "offsets": [ [ 36, 45 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30702
split_0_train_30702
[ { "id": "split_0_train_30702_passage", "type": "progene_text", "text": [ "Apolipoprotein E gene polymorphism and previous alcohol withdrawal seizures ." ], "offsets": [ [ 0, 77 ] ] } ]
[ { "id": "split_0_train_49843_entity", "type": "progene_text", "text": [ "Apolipoprotein E" ], "offsets": [ [ 0, 16 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30703
split_0_train_30703
[ { "id": "split_0_train_30703_passage", "type": "progene_text", "text": [ "Aim of this study was to investigate the possible association of apolipoprotein E ( ApoE ) gene polymorphism with a history of alcohol withdrawal seizures ." ], "offsets": [ [ 0, 156 ] ] } ]
[ { "id": "split_0_train_49844_entity", "type": "progene_text", "text": [ "apolipoprotein E" ], "offsets": [ [ 65, 81 ] ], "normalized": [] }, { "id": "split_0_train_49845_entity", "type": "progene_text", "text": [ "ApoE" ], "offsets": [ [ 84, 88 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30704
split_0_train_30704
[ { "id": "split_0_train_30704_passage", "type": "progene_text", "text": [ "We included 194 patients with alcohol dependence who were divided into patients with ( SZ + ) and without ( SZ-) previous alcohol withdrawal seizures ." ], "offsets": [ [ 0, 151 ] ] } ]
[]
[]
[]
[]
split_0_train_30705
split_0_train_30705
[ { "id": "split_0_train_30705_passage", "type": "progene_text", "text": [ "ApoE genotypes were determined using PCR ." ], "offsets": [ [ 0, 42 ] ] } ]
[ { "id": "split_0_train_49846_entity", "type": "progene_text", "text": [ "ApoE" ], "offsets": [ [ 0, 4 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30706
split_0_train_30706
[ { "id": "split_0_train_30706_passage", "type": "progene_text", "text": [ "For statistical analysis we examined the number of ApoE alleles ( ApoE2 : n = 36 ; ApoE3 : n = 311 ; ApoE4 : n = 41 ) ." ], "offsets": [ [ 0, 119 ] ] } ]
[ { "id": "split_0_train_49847_entity", "type": "progene_text", "text": [ "ApoE" ], "offsets": [ [ 51, 55 ] ], "normalized": [] }, { "id": "split_0_train_49848_entity", "type": "progene_text", "text": [ "ApoE2" ], "offsets": [ [ 66, 71 ] ], "normalized": [] }, { "id": "split_0_train_49849_entity", "type": "progene_text", "text": [ "ApoE3" ], "offsets": [ [ 83, 88 ] ], "normalized": [] }, { "id": "split_0_train_49850_entity", "type": "progene_text", "text": [ "ApoE4" ], "offsets": [ [ 101, 106 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30707
split_0_train_30707
[ { "id": "split_0_train_30707_passage", "type": "progene_text", "text": [ "A significant positive association with a positive history of withdrawal seizures ( SZ+) was found in the ApoE3 allele group ( Fisher 's exact test : p = 0.006 ) while a significant negative association was observed in the ApoE2 allele group ( Fisher 's exact test : p = 0.029 ) ." ], "offsets": [ [ 0, 280 ] ] } ]
[ { "id": "split_0_train_49851_entity", "type": "progene_text", "text": [ "ApoE3" ], "offsets": [ [ 106, 111 ] ], "normalized": [] }, { "id": "split_0_train_49852_entity", "type": "progene_text", "text": [ "ApoE2" ], "offsets": [ [ 223, 228 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30708
split_0_train_30708
[ { "id": "split_0_train_30708_passage", "type": "progene_text", "text": [ "For the ApoE4 allele group no significant differences were found regarding a history of withdrawal seizures ." ], "offsets": [ [ 0, 109 ] ] } ]
[ { "id": "split_0_train_49853_entity", "type": "progene_text", "text": [ "ApoE4" ], "offsets": [ [ 8, 13 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30709
split_0_train_30709
[ { "id": "split_0_train_30709_passage", "type": "progene_text", "text": [ "Our findings suggest an association between the apolipoprotein E3 gene variant and an elevated risk of alcohol withdrawal seizures ." ], "offsets": [ [ 0, 132 ] ] } ]
[ { "id": "split_0_train_49854_entity", "type": "progene_text", "text": [ "apolipoprotein E3" ], "offsets": [ [ 48, 65 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30710
split_0_train_30710
[ { "id": "split_0_train_30710_passage", "type": "progene_text", "text": [ "These preliminary results must be validated in further studies ." ], "offsets": [ [ 0, 64 ] ] } ]
[]
[]
[]
[]
split_0_train_30711
split_0_train_30711
[ { "id": "split_0_train_30711_passage", "type": "progene_text", "text": [ "Molecular analysis of duck hepatitis virus type 1 reveals a novel lineage close to the genus Parechovirus in the family Picornaviridae ." ], "offsets": [ [ 0, 136 ] ] } ]
[]
[]
[]
[]
split_0_train_30712
split_0_train_30712
[ { "id": "split_0_train_30712_passage", "type": "progene_text", "text": [ "Duck hepatitis virus type 1 ( DHV-1 ) was previously classified as an enterovirus , based primarily on observed morphology and physicochemical properties of the virion ." ], "offsets": [ [ 0, 169 ] ] } ]
[]
[]
[]
[]
split_0_train_30713
split_0_train_30713
[ { "id": "split_0_train_30713_passage", "type": "progene_text", "text": [ "The complete nucleotide sequences of two strains ( DRL - 62 and R85952 ) of DHV-1 have been determined ." ], "offsets": [ [ 0, 104 ] ] } ]
[]
[]
[]
[]
split_0_train_30714
split_0_train_30714
[ { "id": "split_0_train_30714_passage", "type": "progene_text", "text": [ "Excluding the poly(A) tail , the genomes are 7691 and 7690 nt , respectively , and contain a single , large open reading frame encoding a polyprotein of 2249 aa ." ], "offsets": [ [ 0, 162 ] ] } ]
[]
[]
[]
[]
split_0_train_30715
split_0_train_30715
[ { "id": "split_0_train_30715_passage", "type": "progene_text", "text": [ "The genome of DHV-1 is organized as are those of members of the family Picornaviridae : 5' untranslated region ( UTR ) - VP0 - VP3 - VP1 - 2A1 - 2A2 - 2B - 2C - 3A - 3B - 3C - 3D - 3' UTR ." ], "offsets": [ [ 0, 189 ] ] } ]
[ { "id": "split_0_train_49855_entity", "type": "progene_text", "text": [ "VP0" ], "offsets": [ [ 121, 124 ] ], "normalized": [] }, { "id": "split_0_train_49856_entity", "type": "progene_text", "text": [ "VP3" ], "offsets": [ [ 127, 130 ] ], "normalized": [] }, { "id": "split_0_train_49857_entity", "type": "progene_text", "text": [ "VP1" ], "offsets": [ [ 133, 136 ] ], "normalized": [] }, { "id": "split_0_train_49858_entity", "type": "progene_text", "text": [ "2A1" ], "offsets": [ [ 139, 142 ] ], "normalized": [] }, { "id": "split_0_train_49859_entity", "type": "progene_text", "text": [ "2A2" ], "offsets": [ [ 145, 148 ] ], "normalized": [] }, { "id": "split_0_train_49860_entity", "type": "progene_text", "text": [ "2B" ], "offsets": [ [ 151, 153 ] ], "normalized": [] }, { "id": "split_0_train_49861_entity", "type": "progene_text", "text": [ "2C" ], "offsets": [ [ 156, 158 ] ], "normalized": [] }, { "id": "split_0_train_49862_entity", "type": "progene_text", "text": [ "3A" ], "offsets": [ [ 161, 163 ] ], "normalized": [] }, { "id": "split_0_train_49863_entity", "type": "progene_text", "text": [ "3B" ], "offsets": [ [ 166, 168 ] ], "normalized": [] }, { "id": "split_0_train_49864_entity", "type": "progene_text", "text": [ "3C" ], "offsets": [ [ 171, 173 ] ], "normalized": [] }, { "id": "split_0_train_49865_entity", "type": "progene_text", "text": [ "3D" ], "offsets": [ [ 176, 178 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30716
split_0_train_30716
[ { "id": "split_0_train_30716_passage", "type": "progene_text", "text": [ "Analysis of the genomic and predicted polyprotein sequences revealed several unusual features , including the absence of a predicted maturation cleavage of VP0 , the presence of two unrelated 2A protein motifs and a 3' UTR extended markedly compared with that of any other picornavirus ." ], "offsets": [ [ 0, 287 ] ] } ]
[ { "id": "split_0_train_49866_entity", "type": "progene_text", "text": [ "VP0" ], "offsets": [ [ 156, 159 ] ], "normalized": [] }, { "id": "split_0_train_49867_entity", "type": "progene_text", "text": [ "2A" ], "offsets": [ [ 192, 194 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30717
split_0_train_30717
[ { "id": "split_0_train_30717_passage", "type": "progene_text", "text": [ "The 2A1 protein motif is related to the 2A protein type of the genus Aphthovirus and the adjacent 2A2 protein is related to the 2A protein type present in the genus Parechovirus ." ], "offsets": [ [ 0, 179 ] ] } ]
[ { "id": "split_0_train_49868_entity", "type": "progene_text", "text": [ "2A1" ], "offsets": [ [ 4, 7 ] ], "normalized": [] }, { "id": "split_0_train_49869_entity", "type": "progene_text", "text": [ "2A" ], "offsets": [ [ 40, 42 ] ], "normalized": [] }, { "id": "split_0_train_49870_entity", "type": "progene_text", "text": [ "2A2" ], "offsets": [ [ 98, 101 ] ], "normalized": [] }, { "id": "split_0_train_49871_entity", "type": "progene_text", "text": [ "2A" ], "offsets": [ [ 128, 130 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30718
split_0_train_30718
[ { "id": "split_0_train_30718_passage", "type": "progene_text", "text": [ "Phylogenetic analysis using the 3D protein sequence shows that the two DHV-1 strains are related more closely to members of the genus Parechovirus than to other picornaviruses ." ], "offsets": [ [ 0, 177 ] ] } ]
[ { "id": "split_0_train_49872_entity", "type": "progene_text", "text": [ "3D" ], "offsets": [ [ 32, 34 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30719
split_0_train_30719
[ { "id": "split_0_train_30719_passage", "type": "progene_text", "text": [ "However , the two DHV-1 strains form a monophyletic group , clearly distinct from members of the genus Parechovirus ." ], "offsets": [ [ 0, 117 ] ] } ]
[]
[]
[]
[]
split_0_train_30720
split_0_train_30720
[ { "id": "split_0_train_30720_passage", "type": "progene_text", "text": [ "Extensive proteolytic processing of the malaria parasite merozoite surface protein 7 during biosynthesis and parasite release from erythrocytes ." ], "offsets": [ [ 0, 145 ] ] } ]
[ { "id": "split_0_train_49873_entity", "type": "progene_text", "text": [ "merozoite surface protein 7" ], "offsets": [ [ 57, 84 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30721
split_0_train_30721
[ { "id": "split_0_train_30721_passage", "type": "progene_text", "text": [ "In Plasmodium falciparum , merozoite surface protein 7 ( MSP7 ) was originally identified as a 22kDa protein on the merozoite surface and associated with the MSP1 complex shed during erythrocyte invasion ." ], "offsets": [ [ 0, 205 ] ] } ]
[ { "id": "split_0_train_49874_entity", "type": "progene_text", "text": [ "merozoite surface protein 7" ], "offsets": [ [ 27, 54 ] ], "normalized": [] }, { "id": "split_0_train_49875_entity", "type": "progene_text", "text": [ "MSP7" ], "offsets": [ [ 57, 61 ] ], "normalized": [] }, { "id": "split_0_train_49876_entity", "type": "progene_text", "text": [ "MSP1 complex" ], "offsets": [ [ 158, 170 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30722
split_0_train_30722
[ { "id": "split_0_train_30722_passage", "type": "progene_text", "text": [ "MSP7 is synthesised in schizonts as a 351 - amino acid precursor that undergoes proteolytic processing ." ], "offsets": [ [ 0, 104 ] ] } ]
[ { "id": "split_0_train_49877_entity", "type": "progene_text", "text": [ "MSP7" ], "offsets": [ [ 0, 4 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30723
split_0_train_30723
[ { "id": "split_0_train_30723_passage", "type": "progene_text", "text": [ "During biosynthesis the MSP1 and MSP7 precursors form a complex that is targeted to the surface of developing merozoites ." ], "offsets": [ [ 0, 122 ] ] } ]
[ { "id": "split_0_train_49878_entity", "type": "progene_text", "text": [ "MSP1" ], "offsets": [ [ 24, 28 ] ], "normalized": [] }, { "id": "split_0_train_49879_entity", "type": "progene_text", "text": [ "MSP7" ], "offsets": [ [ 33, 37 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30724
split_0_train_30724
[ { "id": "split_0_train_30724_passage", "type": "progene_text", "text": [ "In the sequential proteolytic processing of MSP7 , N - and C - terminal 20 and 33kDa products of primary processing , MSP7 ( 20 ) and MSP7 ( 33 ) are formed and MSP7 ( 33 ) remains bound to full length MSP1 ." ], "offsets": [ [ 0, 208 ] ] } ]
[ { "id": "split_0_train_49880_entity", "type": "progene_text", "text": [ "MSP7" ], "offsets": [ [ 44, 48 ] ], "normalized": [] }, { "id": "split_0_train_49881_entity", "type": "progene_text", "text": [ "MSP7" ], "offsets": [ [ 118, 122 ] ], "normalized": [] }, { "id": "split_0_train_49882_entity", "type": "progene_text", "text": [ "MSP7" ], "offsets": [ [ 134, 138 ] ], "normalized": [] }, { "id": "split_0_train_49883_entity", "type": "progene_text", "text": [ "MSP7" ], "offsets": [ [ 161, 165 ] ], "normalized": [] }, { "id": "split_0_train_49884_entity", "type": "progene_text", "text": [ "MSP1" ], "offsets": [ [ 202, 206 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30725
split_0_train_30725
[ { "id": "split_0_train_30725_passage", "type": "progene_text", "text": [ "Later in the mature schizont , MSP7 ( 20 ) disappears from the merozoite surface and on merozoite release MSP7 ( 33 ) undergoes a secondary cleavage yielding the 22kDa MSP7 ( 22 ) associated with MSP1 ." ], "offsets": [ [ 0, 202 ] ] } ]
[ { "id": "split_0_train_49885_entity", "type": "progene_text", "text": [ "MSP7" ], "offsets": [ [ 31, 35 ] ], "normalized": [] }, { "id": "split_0_train_49886_entity", "type": "progene_text", "text": [ "MSP7" ], "offsets": [ [ 106, 110 ] ], "normalized": [] }, { "id": "split_0_train_49887_entity", "type": "progene_text", "text": [ "MSP7" ], "offsets": [ [ 168, 172 ] ], "normalized": [] }, { "id": "split_0_train_49888_entity", "type": "progene_text", "text": [ "MSP1" ], "offsets": [ [ 196, 200 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30726
split_0_train_30726
[ { "id": "split_0_train_30726_passage", "type": "progene_text", "text": [ "In free merozoites , both MSP7 ( 22 ) and a further cleaved product , MSP7 ( 19 ) present only in some parasite lines , were detected ; these two derivatives are shed as part of the protein complex with MSP1 fragments during erythrocyte invasion ." ], "offsets": [ [ 0, 247 ] ] } ]
[ { "id": "split_0_train_49889_entity", "type": "progene_text", "text": [ "MSP7" ], "offsets": [ [ 26, 30 ] ], "normalized": [] }, { "id": "split_0_train_49890_entity", "type": "progene_text", "text": [ "MSP7" ], "offsets": [ [ 70, 74 ] ], "normalized": [] }, { "id": "split_0_train_49891_entity", "type": "progene_text", "text": [ "MSP1" ], "offsets": [ [ 203, 207 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30727
split_0_train_30727
[ { "id": "split_0_train_30727_passage", "type": "progene_text", "text": [ "Primary processing of MSP7 is brefeldin A - sensitive while secondary processing is resistant to both calcium chelators and serine protease inhibitors ." ], "offsets": [ [ 0, 152 ] ] } ]
[ { "id": "split_0_train_49892_entity", "type": "progene_text", "text": [ "MSP7" ], "offsets": [ [ 22, 26 ] ], "normalized": [] }, { "id": "split_0_train_49893_entity", "type": "progene_text", "text": [ "serine protease" ], "offsets": [ [ 124, 139 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30728
split_0_train_30728
[ { "id": "split_0_train_30728_passage", "type": "progene_text", "text": [ "Primary processing of MSP7 occurs prior to that of MSP1 in a post - Golgi compartment , whereas the secondary cleavage occurs on the surface of the developing merozoite , possibly at the time of MSP1 primary processing and well before the secondary processing of MSP1 ." ], "offsets": [ [ 0, 269 ] ] } ]
[ { "id": "split_0_train_49894_entity", "type": "progene_text", "text": [ "MSP7" ], "offsets": [ [ 22, 26 ] ], "normalized": [] }, { "id": "split_0_train_49895_entity", "type": "progene_text", "text": [ "MSP1" ], "offsets": [ [ 51, 55 ] ], "normalized": [] }, { "id": "split_0_train_49896_entity", "type": "progene_text", "text": [ "MSP1" ], "offsets": [ [ 195, 199 ] ], "normalized": [] }, { "id": "split_0_train_49897_entity", "type": "progene_text", "text": [ "MSP1" ], "offsets": [ [ 263, 267 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30729
split_0_train_30729
[ { "id": "split_0_train_30729_passage", "type": "progene_text", "text": [ "The spreading of HIV-1 infection in the human organism is caused by fractalkine trafficking of the infected lymphocytes -- a review , hypothesis and implications for treatment ." ], "offsets": [ [ 0, 177 ] ] } ]
[ { "id": "split_0_train_49898_entity", "type": "progene_text", "text": [ "fractalkine" ], "offsets": [ [ 68, 79 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30730
split_0_train_30730
[ { "id": "split_0_train_30730_passage", "type": "progene_text", "text": [ "The reviews on HIV-1 / AIDS [ 1-8] highlighted the mechanism by which HIV-1 virions utilize dendritic cells ( DCs ) for transport from the genitals , the portal of virus infection , to the draining lymph nodes where DCs carry HIV - 1 virions and present viral antigens by HLA class I and II to CD4 ( + ) T cells ." ], "offsets": [ [ 0, 313 ] ] } ]
[ { "id": "split_0_train_49899_entity", "type": "progene_text", "text": [ "HLA class I and II" ], "offsets": [ [ 272, 290 ] ], "normalized": [] }, { "id": "split_0_train_49900_entity", "type": "progene_text", "text": [ "CD4" ], "offsets": [ [ 294, 297 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30731
split_0_train_30731
[ { "id": "split_0_train_30731_passage", "type": "progene_text", "text": [ "Interaction of the T cells with viral antigens presented by HLA class II molecules polarizes them to become Th2 cells , the targets of HIV - 1 infection and producers of HIV - 1 progeny virions ." ], "offsets": [ [ 0, 195 ] ] } ]
[ { "id": "split_0_train_49901_entity", "type": "progene_text", "text": [ "HLA class II" ], "offsets": [ [ 60, 72 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30732
split_0_train_30732
[ { "id": "split_0_train_30732_passage", "type": "progene_text", "text": [ "The T cells which interact with viral antigen presented by HLA class I polarize to become Th1 cells , which stimulate the CD8 ( + ) T cell precursors to develop into antiviral cytotoxic T cells ." ], "offsets": [ [ 0, 195 ] ] } ]
[ { "id": "split_0_train_49902_entity", "type": "progene_text", "text": [ "HLA class I" ], "offsets": [ [ 59, 70 ] ], "normalized": [] }, { "id": "split_0_train_49903_entity", "type": "progene_text", "text": [ "CD8" ], "offsets": [ [ 122, 125 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30733
split_0_train_30733
[ { "id": "split_0_train_30733_passage", "type": "progene_text", "text": [ "In addition , HIV-1 virions shed gp120 glycoprotein molecules which bind to IgE immunoglobulin molecules bound to FCepsilonRI + innate system cells ( basophils , mast cells and monocytes ) and induce them to release large amounts of Th2 cytokines ( IL-4 , IL-5 , IL - 10 , IL-13 ) , thereby creating an allergy - like condition ." ], "offsets": [ [ 0, 329 ] ] } ]
[ { "id": "split_0_train_49904_entity", "type": "progene_text", "text": [ "gp120" ], "offsets": [ [ 33, 38 ] ], "normalized": [] }, { "id": "split_0_train_49905_entity", "type": "progene_text", "text": [ "IgE" ], "offsets": [ [ 76, 79 ] ], "normalized": [] }, { "id": "split_0_train_49906_entity", "type": "progene_text", "text": [ "immunoglobulin" ], "offsets": [ [ 80, 94 ] ], "normalized": [] }, { "id": "split_0_train_49907_entity", "type": "progene_text", "text": [ "FCepsilonRI" ], "offsets": [ [ 114, 125 ] ], "normalized": [] }, { "id": "split_0_train_49908_entity", "type": "progene_text", "text": [ "cytokines" ], "offsets": [ [ 237, 246 ] ], "normalized": [] }, { "id": "split_0_train_49909_entity", "type": "progene_text", "text": [ "IL-4" ], "offsets": [ [ 249, 253 ] ], "normalized": [] }, { "id": "split_0_train_49910_entity", "type": "progene_text", "text": [ "IL-5" ], "offsets": [ [ 256, 260 ] ], "normalized": [] }, { "id": "split_0_train_49911_entity", "type": "progene_text", "text": [ "IL - 10" ], "offsets": [ [ 263, 270 ] ], "normalized": [] }, { "id": "split_0_train_49912_entity", "type": "progene_text", "text": [ "IL-13" ], "offsets": [ [ 273, 278 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30734
split_0_train_30734
[ { "id": "split_0_train_30734_passage", "type": "progene_text", "text": [ "The present review attempts to define the role of chemokine receptors like CCR5 and CXCR4 , and especially fractalkine receptor CX3CR1 in the trafficking of lymphocytes in healthy individuals and HIV - 1 / AIDS patients ." ], "offsets": [ [ 0, 221 ] ] } ]
[ { "id": "split_0_train_49913_entity", "type": "progene_text", "text": [ "chemokine receptors" ], "offsets": [ [ 50, 69 ] ], "normalized": [] }, { "id": "split_0_train_49914_entity", "type": "progene_text", "text": [ "CCR5" ], "offsets": [ [ 75, 79 ] ], "normalized": [] }, { "id": "split_0_train_49915_entity", "type": "progene_text", "text": [ "CXCR4" ], "offsets": [ [ 84, 89 ] ], "normalized": [] }, { "id": "split_0_train_49916_entity", "type": "progene_text", "text": [ "fractalkine receptor" ], "offsets": [ [ 107, 127 ] ], "normalized": [] }, { "id": "split_0_train_49917_entity", "type": "progene_text", "text": [ "CX3CR1" ], "offsets": [ [ 128, 134 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30735
split_0_train_30735
[ { "id": "split_0_train_30735_passage", "type": "progene_text", "text": [ "The role of chemokine receptors as co - receptors for HIV-1 virion gp120 glycoprotein has been defined , but the role of fractalkine and fractalkine receptor has been clarified only recently [ 9 - 19 ] ." ], "offsets": [ [ 0, 203 ] ] } ]
[ { "id": "split_0_train_49918_entity", "type": "progene_text", "text": [ "chemokine receptors" ], "offsets": [ [ 12, 31 ] ], "normalized": [] }, { "id": "split_0_train_49919_entity", "type": "progene_text", "text": [ "gp120" ], "offsets": [ [ 67, 72 ] ], "normalized": [] }, { "id": "split_0_train_49920_entity", "type": "progene_text", "text": [ "fractalkine" ], "offsets": [ [ 121, 132 ] ], "normalized": [] }, { "id": "split_0_train_49921_entity", "type": "progene_text", "text": [ "fractalkine receptor" ], "offsets": [ [ 137, 157 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30736
split_0_train_30736
[ { "id": "split_0_train_30736_passage", "type": "progene_text", "text": [ "In healthy individuals fractalkine is expressed by blood vessel endothelial cells and the CX3CR1 receptors are expressed on leukocytes that migrate in the peripheral blood in the direction of increased fractalkine concentration ." ], "offsets": [ [ 0, 229 ] ] } ]
[ { "id": "split_0_train_49922_entity", "type": "progene_text", "text": [ "fractalkine" ], "offsets": [ [ 23, 34 ] ], "normalized": [] }, { "id": "split_0_train_49923_entity", "type": "progene_text", "text": [ "CX3CR1" ], "offsets": [ [ 90, 96 ] ], "normalized": [] }, { "id": "split_0_train_49924_entity", "type": "progene_text", "text": [ "fractalkine" ], "offsets": [ [ 202, 213 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30737
split_0_train_30737
[ { "id": "split_0_train_30737_passage", "type": "progene_text", "text": [ "In HIV-1 / AIDS patients the virus - infected CD4 ( + ) Th2 cells migrate to organs that harbor the adaptive immune system cells in the thymus , genitals , gastrointestinal tract , and to the brain ." ], "offsets": [ [ 0, 199 ] ] } ]
[ { "id": "split_0_train_49925_entity", "type": "progene_text", "text": [ "CD4" ], "offsets": [ [ 46, 49 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30738
split_0_train_30738
[ { "id": "split_0_train_30738_passage", "type": "progene_text", "text": [ "A most significant finding which revealed the importance of the human CX3CR1 gene expression to the progression of the infection to the stage of AIDS was recently reported by Faure and collaborators [ 20 , 21 ] who showed that the delayed or rapid progression to AIDS was affected in HIV-1 - infected individuals who had inherited a fractalkine receptor gene with the polymorphisms V249I or T280M , respectively , located in the sixth and seventh transmembrane domains of CX3CR1 protein ." ], "offsets": [ [ 0, 488 ] ] } ]
[ { "id": "split_0_train_49926_entity", "type": "progene_text", "text": [ "CX3CR1" ], "offsets": [ [ 70, 76 ] ], "normalized": [] }, { "id": "split_0_train_49927_entity", "type": "progene_text", "text": [ "fractalkine receptor" ], "offsets": [ [ 333, 353 ] ], "normalized": [] }, { "id": "split_0_train_49928_entity", "type": "progene_text", "text": [ "CX3CR1" ], "offsets": [ [ 472, 478 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30739
split_0_train_30739
[ { "id": "split_0_train_30739_passage", "type": "progene_text", "text": [ "The T280M mutation in the CX3CR1 gene caused a rapid progression to AIDS , while in patients with the V249I mutation progression to AIDS was much slower ." ], "offsets": [ [ 0, 154 ] ] } ]
[ { "id": "split_0_train_49929_entity", "type": "progene_text", "text": [ "CX3CR1" ], "offsets": [ [ 26, 32 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30740
split_0_train_30740
[ { "id": "split_0_train_30740_passage", "type": "progene_text", "text": [ "These studies led to the idea that it might be possible to slow or prevent HIV-1 / AIDS progression in HIV-1 patients by treating them with fractalkine antagonists that will bind to and inhibit the activity of the fractalkine receptor ." ], "offsets": [ [ 0, 236 ] ] } ]
[ { "id": "split_0_train_49930_entity", "type": "progene_text", "text": [ "fractalkine" ], "offsets": [ [ 140, 151 ] ], "normalized": [] }, { "id": "split_0_train_49931_entity", "type": "progene_text", "text": [ "fractalkine receptor" ], "offsets": [ [ 214, 234 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30741
split_0_train_30741
[ { "id": "split_0_train_30741_passage", "type": "progene_text", "text": [ "It is hypothesized that treatment of HIV-1 / AIDS patients with a combination of fractalkine antagonists , IL-4 antagonist IL-4delta2 and the adjuvant CpG ODN induced release of type I IFN from PDF , and may inhibit HIV - 1 infection , especially in HAART - treated patients infected with drug - resistant HIV - 1 mutants due to prevention of the availability of immune cells needed for the viral evasion of the immune response ." ], "offsets": [ [ 0, 429 ] ] } ]
[ { "id": "split_0_train_49932_entity", "type": "progene_text", "text": [ "fractalkine" ], "offsets": [ [ 81, 92 ] ], "normalized": [] }, { "id": "split_0_train_49933_entity", "type": "progene_text", "text": [ "IL-4" ], "offsets": [ [ 107, 111 ] ], "normalized": [] }, { "id": "split_0_train_49934_entity", "type": "progene_text", "text": [ "IL-4delta2" ], "offsets": [ [ 123, 133 ] ], "normalized": [] }, { "id": "split_0_train_49935_entity", "type": "progene_text", "text": [ "type I IFN" ], "offsets": [ [ 178, 188 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30742
split_0_train_30742
[ { "id": "split_0_train_30742_passage", "type": "progene_text", "text": [ "The hypothesis implies that the advantage of the suggested mode of treatment of HIV-1 - infected people is prevention of cellular processes that are used by the viral protein to cause immunodeficiency , and prevention of HIV - 1 replication without induction of resistant mutants ." ], "offsets": [ [ 0, 281 ] ] } ]
[]
[]
[]
[]
split_0_train_30743
split_0_train_30743
[ { "id": "split_0_train_30743_passage", "type": "progene_text", "text": [ "cDNA cloning and expression of a human FGF receptor which binds acidic and basic FGF ." ], "offsets": [ [ 0, 86 ] ] } ]
[ { "id": "split_0_train_49936_entity", "type": "progene_text", "text": [ "FGF receptor" ], "offsets": [ [ 39, 51 ] ], "normalized": [] }, { "id": "split_0_train_49937_entity", "type": "progene_text", "text": [ "acidic and basic FGF" ], "offsets": [ [ 64, 84 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30744
split_0_train_30744
[ { "id": "split_0_train_30744_passage", "type": "progene_text", "text": [ "We have isolated and characterized a cDNA clone , phFGFR , encoding a human fibroblast growth factor ( FGF ) receptor ." ], "offsets": [ [ 0, 119 ] ] } ]
[ { "id": "split_0_train_49938_entity", "type": "progene_text", "text": [ "phFGFR" ], "offsets": [ [ 50, 56 ] ], "normalized": [] }, { "id": "split_0_train_49939_entity", "type": "progene_text", "text": [ "fibroblast growth factor ( FGF ) receptor" ], "offsets": [ [ 76, 117 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30745
split_0_train_30745
[ { "id": "split_0_train_30745_passage", "type": "progene_text", "text": [ "phFGFR contains an open reading frame which encodes an 820 amino acid polypeptide with three immunoglobulin - like domains in the extracellular part and an intracellular split tyrosine kinase domain ." ], "offsets": [ [ 0, 200 ] ] } ]
[ { "id": "split_0_train_49940_entity", "type": "progene_text", "text": [ "phFGFR" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "split_0_train_49941_entity", "type": "progene_text", "text": [ "immunoglobulin" ], "offsets": [ [ 93, 107 ] ], "normalized": [] }, { "id": "split_0_train_49942_entity", "type": "progene_text", "text": [ "tyrosine kinase" ], "offsets": [ [ 176, 191 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30746
split_0_train_30746
[ { "id": "split_0_train_30746_passage", "type": "progene_text", "text": [ "Transient expression in COS-1 cells and immunoprecipitation using an antiserum raised against a C - terminal peptide , gave rise to two components , representing mature ( 130 kDa ) and precursor ( 115 kDa ) forms of the phFGFR encoded polypeptide , which was denoted hFGFR-1 ." ], "offsets": [ [ 0, 276 ] ] } ]
[ { "id": "split_0_train_49943_entity", "type": "progene_text", "text": [ "phFGFR" ], "offsets": [ [ 220, 226 ] ], "normalized": [] }, { "id": "split_0_train_49944_entity", "type": "progene_text", "text": [ "hFGFR-1" ], "offsets": [ [ 267, 274 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30747
split_0_train_30747
[ { "id": "split_0_train_30747_passage", "type": "progene_text", "text": [ "Crosslinking of iodinated acidic FGF ( aFGF ) and basic FGF ( bFGF ) to transiently expressing COS-1 cells revealed a major band of 95 kDa , which was competed for by both aFGF and bFGF ." ], "offsets": [ [ 0, 187 ] ] } ]
[ { "id": "split_0_train_49945_entity", "type": "progene_text", "text": [ "acidic FGF" ], "offsets": [ [ 26, 36 ] ], "normalized": [] }, { "id": "split_0_train_49946_entity", "type": "progene_text", "text": [ "aFGF" ], "offsets": [ [ 39, 43 ] ], "normalized": [] }, { "id": "split_0_train_49947_entity", "type": "progene_text", "text": [ "basic FGF" ], "offsets": [ [ 50, 59 ] ], "normalized": [] }, { "id": "split_0_train_49948_entity", "type": "progene_text", "text": [ "bFGF" ], "offsets": [ [ 62, 66 ] ], "normalized": [] }, { "id": "split_0_train_49949_entity", "type": "progene_text", "text": [ "aFGF" ], "offsets": [ [ 172, 176 ] ], "normalized": [] }, { "id": "split_0_train_49950_entity", "type": "progene_text", "text": [ "bFGF" ], "offsets": [ [ 181, 185 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30748
split_0_train_30748
[ { "id": "split_0_train_30748_passage", "type": "progene_text", "text": [ "From Scatchard analyses , the Kd :s for binding of aFGF and bFGF to hFGFR-1 were estimated to 25 pM and 41 pM , respectively ." ], "offsets": [ [ 0, 126 ] ] } ]
[ { "id": "split_0_train_49951_entity", "type": "progene_text", "text": [ "aFGF" ], "offsets": [ [ 51, 55 ] ], "normalized": [] }, { "id": "split_0_train_49952_entity", "type": "progene_text", "text": [ "bFGF" ], "offsets": [ [ 60, 64 ] ], "normalized": [] }, { "id": "split_0_train_49953_entity", "type": "progene_text", "text": [ "hFGFR-1" ], "offsets": [ [ 68, 75 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30749
split_0_train_30749
[ { "id": "split_0_train_30749_passage", "type": "progene_text", "text": [ "Thus , phFGFR encodes a human FGF receptor with high affinity for both aFGF and bFGF ." ], "offsets": [ [ 0, 86 ] ] } ]
[ { "id": "split_0_train_49954_entity", "type": "progene_text", "text": [ "phFGFR" ], "offsets": [ [ 7, 13 ] ], "normalized": [] }, { "id": "split_0_train_49955_entity", "type": "progene_text", "text": [ "FGF receptor" ], "offsets": [ [ 30, 42 ] ], "normalized": [] }, { "id": "split_0_train_49956_entity", "type": "progene_text", "text": [ "aFGF" ], "offsets": [ [ 71, 75 ] ], "normalized": [] }, { "id": "split_0_train_49957_entity", "type": "progene_text", "text": [ "bFGF" ], "offsets": [ [ 80, 84 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30750
split_0_train_30750
[ { "id": "split_0_train_30750_passage", "type": "progene_text", "text": [ "Glutamatergic or GABAergic neuron - specific , long - term expression in neocortical neurons from helper virus - free HSV-1 vectors containing the phosphate - activated glutaminase , vesicular glutamate transporter-1 , or glutamic acid decarboxylase promoter ." ], "offsets": [ [ 0, 260 ] ] } ]
[ { "id": "split_0_train_49958_entity", "type": "progene_text", "text": [ "phosphate - activated glutaminase" ], "offsets": [ [ 147, 180 ] ], "normalized": [] }, { "id": "split_0_train_49959_entity", "type": "progene_text", "text": [ "vesicular glutamate transporter-1" ], "offsets": [ [ 183, 216 ] ], "normalized": [] }, { "id": "split_0_train_49960_entity", "type": "progene_text", "text": [ "glutamic acid decarboxylase" ], "offsets": [ [ 222, 249 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30751
split_0_train_30751
[ { "id": "split_0_train_30751_passage", "type": "progene_text", "text": [ "Many potential uses of direct gene transfer into neurons require restricting expression to one of the two major types of forebrain neurons , glutamatergic or GABAergic neurons ." ], "offsets": [ [ 0, 177 ] ] } ]
[]
[]
[]
[]
split_0_train_30752
split_0_train_30752
[ { "id": "split_0_train_30752_passage", "type": "progene_text", "text": [ "Thus , it is desirable to develop virus vectors that contain either a glutamatergic or GABAergic neuron - specific promoter ." ], "offsets": [ [ 0, 125 ] ] } ]
[]
[]
[]
[]
split_0_train_30753
split_0_train_30753
[ { "id": "split_0_train_30753_passage", "type": "progene_text", "text": [ "The brain / kidney phosphate - activated glutaminase ( PAG ) , the product of the GLS1 gene , produces the majority of the glutamate for release as neurotransmitter , and is a marker for glutamatergic neurons ." ], "offsets": [ [ 0, 210 ] ] } ]
[ { "id": "split_0_train_49961_entity", "type": "progene_text", "text": [ "phosphate - activated glutaminase" ], "offsets": [ [ 19, 52 ] ], "normalized": [] }, { "id": "split_0_train_49962_entity", "type": "progene_text", "text": [ "PAG" ], "offsets": [ [ 55, 58 ] ], "normalized": [] }, { "id": "split_0_train_49963_entity", "type": "progene_text", "text": [ "GLS1" ], "offsets": [ [ 82, 86 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30754
split_0_train_30754
[ { "id": "split_0_train_30754_passage", "type": "progene_text", "text": [ "A PAG promoter was partially characterized using a cultured kidney cell line ." ], "offsets": [ [ 0, 78 ] ] } ]
[ { "id": "split_0_train_49964_entity", "type": "progene_text", "text": [ "PAG" ], "offsets": [ [ 2, 5 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30755
split_0_train_30755
[ { "id": "split_0_train_30755_passage", "type": "progene_text", "text": [ "The three vesicular glutamate transporters ( VGLUTs ) are expressed in distinct populations of neurons , and VGLUT1 is the predominant VGLUT in the neocortex , hippocampus , and cerebellar cortex ." ], "offsets": [ [ 0, 197 ] ] } ]
[ { "id": "split_0_train_49965_entity", "type": "progene_text", "text": [ "vesicular glutamate transporters" ], "offsets": [ [ 10, 42 ] ], "normalized": [] }, { "id": "split_0_train_49966_entity", "type": "progene_text", "text": [ "VGLUTs" ], "offsets": [ [ 45, 51 ] ], "normalized": [] }, { "id": "split_0_train_49967_entity", "type": "progene_text", "text": [ "VGLUT1" ], "offsets": [ [ 109, 115 ] ], "normalized": [] }, { "id": "split_0_train_49968_entity", "type": "progene_text", "text": [ "VGLUT" ], "offsets": [ [ 135, 140 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30756
split_0_train_30756
[ { "id": "split_0_train_30756_passage", "type": "progene_text", "text": [ "Glutamic acid decarboxylase ( GAD ) produces GABA ; the two molecular forms of the enzyme , GAD65 and GAD67 , are expressed in distinct , but largely overlapping , groups of neurons , and GAD67 is the predominant form in the neocortex ." ], "offsets": [ [ 0, 236 ] ] } ]
[ { "id": "split_0_train_49969_entity", "type": "progene_text", "text": [ "Glutamic acid decarboxylase" ], "offsets": [ [ 0, 27 ] ], "normalized": [] }, { "id": "split_0_train_49970_entity", "type": "progene_text", "text": [ "GAD" ], "offsets": [ [ 30, 33 ] ], "normalized": [] }, { "id": "split_0_train_49971_entity", "type": "progene_text", "text": [ "GAD65" ], "offsets": [ [ 92, 97 ] ], "normalized": [] }, { "id": "split_0_train_49972_entity", "type": "progene_text", "text": [ "GAD67" ], "offsets": [ [ 102, 107 ] ], "normalized": [] }, { "id": "split_0_train_49973_entity", "type": "progene_text", "text": [ "GAD67" ], "offsets": [ [ 188, 193 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30757
split_0_train_30757
[ { "id": "split_0_train_30757_passage", "type": "progene_text", "text": [ "In transgenic mice , an approximately 9 kb fragment of the GAD67 promoter supports expression in most classes of GABAergic neurons ." ], "offsets": [ [ 0, 132 ] ] } ]
[ { "id": "split_0_train_49974_entity", "type": "progene_text", "text": [ "GAD67" ], "offsets": [ [ 59, 64 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30758
split_0_train_30758
[ { "id": "split_0_train_30758_passage", "type": "progene_text", "text": [ "Here , we constructed plasmid ( amplicon ) Herpes Simplex Virus ( HSV-1 ) vectors that placed the Lac Z gene under the regulation of putative PAG , VGLUT1 , or GAD67 promoters ." ], "offsets": [ [ 0, 177 ] ] } ]
[ { "id": "split_0_train_49975_entity", "type": "progene_text", "text": [ "Lac Z" ], "offsets": [ [ 98, 103 ] ], "normalized": [] }, { "id": "split_0_train_49976_entity", "type": "progene_text", "text": [ "PAG" ], "offsets": [ [ 142, 145 ] ], "normalized": [] }, { "id": "split_0_train_49977_entity", "type": "progene_text", "text": [ "VGLUT1" ], "offsets": [ [ 148, 154 ] ], "normalized": [] }, { "id": "split_0_train_49978_entity", "type": "progene_text", "text": [ "GAD67" ], "offsets": [ [ 160, 165 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30759
split_0_train_30759
[ { "id": "split_0_train_30759_passage", "type": "progene_text", "text": [ "Helper virus - free vector stocks were delivered into postrhinal cortex , and the rats were sacrificed 4 days or 2 months later ." ], "offsets": [ [ 0, 129 ] ] } ]
[]
[]
[]
[]
split_0_train_30760
split_0_train_30760
[ { "id": "split_0_train_30760_passage", "type": "progene_text", "text": [ "The PAG or VGLUT1 promoters supported approximately 90 % glutamatergic neuron - specific expression ." ], "offsets": [ [ 0, 101 ] ] } ]
[ { "id": "split_0_train_49979_entity", "type": "progene_text", "text": [ "PAG" ], "offsets": [ [ 4, 7 ] ], "normalized": [] }, { "id": "split_0_train_49980_entity", "type": "progene_text", "text": [ "VGLUT1" ], "offsets": [ [ 11, 17 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30761
split_0_train_30761
[ { "id": "split_0_train_30761_passage", "type": "progene_text", "text": [ "The GAD67 promoter supported approximately 90 % GABAergic neuron - specific expression ." ], "offsets": [ [ 0, 88 ] ] } ]
[ { "id": "split_0_train_49981_entity", "type": "progene_text", "text": [ "GAD67" ], "offsets": [ [ 4, 9 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30762
split_0_train_30762
[ { "id": "split_0_train_30762_passage", "type": "progene_text", "text": [ "Long - term expression was observed using each promoter ." ], "offsets": [ [ 0, 57 ] ] } ]
[]
[]
[]
[]
split_0_train_30763
split_0_train_30763
[ { "id": "split_0_train_30763_passage", "type": "progene_text", "text": [ "Principles for obtaining long - term expression from HSV-1 vectors , based on these and other results , are discussed ." ], "offsets": [ [ 0, 119 ] ] } ]
[]
[]
[]
[]
split_0_train_30764
split_0_train_30764
[ { "id": "split_0_train_30764_passage", "type": "progene_text", "text": [ "Long - term glutamatergic or GABAergic neuron - specific expression may benefit specific experiments on learning or specific gene therapy approaches ." ], "offsets": [ [ 0, 150 ] ] } ]
[]
[]
[]
[]
split_0_train_30765
split_0_train_30765
[ { "id": "split_0_train_30765_passage", "type": "progene_text", "text": [ "Of note , promoter analyses might identify regulatory elements that determine a glutamatergic or GABAergic neuron ." ], "offsets": [ [ 0, 115 ] ] } ]
[]
[]
[]
[]
split_0_train_30766
split_0_train_30766
[ { "id": "split_0_train_30766_passage", "type": "progene_text", "text": [ "Genetic method to identify regulons controlled by nonessential elements : isolation of a gene dependent on alternate transcription factor sigma B of Bacillus subtilis ." ], "offsets": [ [ 0, 168 ] ] } ]
[ { "id": "split_0_train_49982_entity", "type": "progene_text", "text": [ "transcription factor" ], "offsets": [ [ 117, 137 ] ], "normalized": [] }, { "id": "split_0_train_49983_entity", "type": "progene_text", "text": [ "sigma B" ], "offsets": [ [ 138, 145 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30767
split_0_train_30767
[ { "id": "split_0_train_30767_passage", "type": "progene_text", "text": [ "We describe a general , in vivo method for identifying Bacillus subtilis genes controlled by specific , nonessential regulatory factors ." ], "offsets": [ [ 0, 137 ] ] } ]
[]
[]
[]
[]
split_0_train_30768
split_0_train_30768
[ { "id": "split_0_train_30768_passage", "type": "progene_text", "text": [ "We establish the use of this approach by identifying , isolating , and characterizing a gene dependent on sigma B , an alternate transcription factor which is found early in stationary phase but which is not essential for sporulation ." ], "offsets": [ [ 0, 235 ] ] } ]
[ { "id": "split_0_train_49984_entity", "type": "progene_text", "text": [ "sigma B" ], "offsets": [ [ 106, 113 ] ], "normalized": [] }, { "id": "split_0_train_49985_entity", "type": "progene_text", "text": [ "transcription factor" ], "offsets": [ [ 129, 149 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30769
split_0_train_30769
[ { "id": "split_0_train_30769_passage", "type": "progene_text", "text": [ "The method relies on two features : (i) a plate transformation technique to introduce a null mutation into the regulatory gene of interest and (ii) random transcriptional fusions to a reporter gene to monitor gene expression in the presence and absence of a functional regulatory product ." ], "offsets": [ [ 0, 289 ] ] } ]
[]
[]
[]
[]
split_0_train_30770
split_0_train_30770
[ { "id": "split_0_train_30770_passage", "type": "progene_text", "text": [ "We applied this genetic approach to isolate genes comprising the sigma B regulon ." ], "offsets": [ [ 0, 82 ] ] } ]
[ { "id": "split_0_train_49986_entity", "type": "progene_text", "text": [ "sigma B" ], "offsets": [ [ 65, 72 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30771
split_0_train_30771
[ { "id": "split_0_train_30771_passage", "type": "progene_text", "text": [ "We screened a random Tn917lacZ library for fusions that required an intact sigma B structural gene ( sigB ) for greatest expression , converting the library strains from wild - type sigB + to sigB delta : : cat directly on plates selective for chloramphenicol resistance ." ], "offsets": [ [ 0, 272 ] ] } ]
[ { "id": "split_0_train_49987_entity", "type": "progene_text", "text": [ "sigma B" ], "offsets": [ [ 75, 82 ] ], "normalized": [] }, { "id": "split_0_train_49988_entity", "type": "progene_text", "text": [ "sigB" ], "offsets": [ [ 101, 105 ] ], "normalized": [] }, { "id": "split_0_train_49989_entity", "type": "progene_text", "text": [ "sigB" ], "offsets": [ [ 182, 186 ] ], "normalized": [] }, { "id": "split_0_train_49990_entity", "type": "progene_text", "text": [ "sigB" ], "offsets": [ [ 192, 196 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30772
split_0_train_30772
[ { "id": "split_0_train_30772_passage", "type": "progene_text", "text": [ "We isolated one such fusion , csbA : : Tn917lacZ ( csb for controlled by sigma B ) , which mapped between hisA and degSU on the B. subtilis chromosome ." ], "offsets": [ [ 0, 152 ] ] } ]
[ { "id": "split_0_train_49991_entity", "type": "progene_text", "text": [ "hisA" ], "offsets": [ [ 106, 110 ] ], "normalized": [] }, { "id": "split_0_train_49992_entity", "type": "progene_text", "text": [ "degSU" ], "offsets": [ [ 115, 120 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30773
split_0_train_30773
[ { "id": "split_0_train_30773_passage", "type": "progene_text", "text": [ "We cloned the region surrounding the insertion , identified the csbA reading frame containing the transposon , and found that this frame encoded a predicted 76 - residue product which was extremely hydrophobic and highly basic ." ], "offsets": [ [ 0, 228 ] ] } ]
[]
[]
[]
[]
split_0_train_30774
split_0_train_30774
[ { "id": "split_0_train_30774_passage", "type": "progene_text", "text": [ "Primer extension and promoter activity experiments identified a sigma B - dependent promoter 83 bp upstream of the csbA coding sequence ." ], "offsets": [ [ 0, 137 ] ] } ]
[ { "id": "split_0_train_49993_entity", "type": "progene_text", "text": [ "sigma B" ], "offsets": [ [ 64, 71 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30775
split_0_train_30775
[ { "id": "split_0_train_30775_passage", "type": "progene_text", "text": [ "A weaker , tandem , sigma A - like promoter was likewise identified 28 bp upstream of csbA ." ], "offsets": [ [ 0, 92 ] ] } ]
[ { "id": "split_0_train_49994_entity", "type": "progene_text", "text": [ "sigma A" ], "offsets": [ [ 20, 27 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30776
split_0_train_30776
[ { "id": "split_0_train_30776_passage", "type": "progene_text", "text": [ "The csbA fusion was maximally expressed during early stationary phase in cells grown in Luria broth containing 5 % glucose and 0.2 % glutamine ." ], "offsets": [ [ 0, 144 ] ] } ]
[]
[]
[]
[]
split_0_train_30777
split_0_train_30777
[ { "id": "split_0_train_30777_passage", "type": "progene_text", "text": [ "This timing of expression and medium dependence were very similar to those for ctc , the only other recognized gene dependent on sigma B ." ], "offsets": [ [ 0, 138 ] ] } ]
[ { "id": "split_0_train_49995_entity", "type": "progene_text", "text": [ "sigma B" ], "offsets": [ [ 129, 136 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30778
split_0_train_30778
[ { "id": "split_0_train_30778_passage", "type": "progene_text", "text": [ "Argininosuccinate synthetase and argininosuccinate lyase : two ornithine cycle enzymes from Agaricus bisporus ." ], "offsets": [ [ 0, 111 ] ] } ]
[ { "id": "split_0_train_49996_entity", "type": "progene_text", "text": [ "Argininosuccinate synthetase" ], "offsets": [ [ 0, 28 ] ], "normalized": [] }, { "id": "split_0_train_49997_entity", "type": "progene_text", "text": [ "argininosuccinate lyase" ], "offsets": [ [ 33, 56 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30779
split_0_train_30779
[ { "id": "split_0_train_30779_passage", "type": "progene_text", "text": [ "Accumulation of high quantities of urea in fruiting bodies is a known feature of larger basidiomycetes ." ], "offsets": [ [ 0, 104 ] ] } ]
[]
[]
[]
[]
split_0_train_30780
split_0_train_30780
[ { "id": "split_0_train_30780_passage", "type": "progene_text", "text": [ "Argininosuccinate synthetase ( ASS ) and argininosuccinate lyase ( ASL ) are two ornithine cycle enzymes catalysing the last two steps in the arginine biosynthetic pathway ." ], "offsets": [ [ 0, 173 ] ] } ]
[ { "id": "split_0_train_49998_entity", "type": "progene_text", "text": [ "Argininosuccinate synthetase" ], "offsets": [ [ 0, 28 ] ], "normalized": [] }, { "id": "split_0_train_49999_entity", "type": "progene_text", "text": [ "ASS" ], "offsets": [ [ 31, 34 ] ], "normalized": [] }, { "id": "split_0_train_50000_entity", "type": "progene_text", "text": [ "argininosuccinate lyase" ], "offsets": [ [ 41, 64 ] ], "normalized": [] }, { "id": "split_0_train_50001_entity", "type": "progene_text", "text": [ "ASL" ], "offsets": [ [ 67, 70 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30781
split_0_train_30781
[ { "id": "split_0_train_30781_passage", "type": "progene_text", "text": [ "Arginine is the main precursor for urea formation ." ], "offsets": [ [ 0, 51 ] ] } ]
[]
[]
[]
[]
split_0_train_30782
split_0_train_30782
[ { "id": "split_0_train_30782_passage", "type": "progene_text", "text": [ "In this work the nucleotide sequences of the genes and corresponding cDNAs encoding argininosuccinate synthetase ( ass ) and argininosuccinate lyase ( asl ) from Agaricus bisporus were determined ." ], "offsets": [ [ 0, 197 ] ] } ]
[ { "id": "split_0_train_50002_entity", "type": "progene_text", "text": [ "argininosuccinate synthetase" ], "offsets": [ [ 84, 112 ] ], "normalized": [] }, { "id": "split_0_train_50003_entity", "type": "progene_text", "text": [ "ass" ], "offsets": [ [ 115, 118 ] ], "normalized": [] }, { "id": "split_0_train_50004_entity", "type": "progene_text", "text": [ "argininosuccinate lyase" ], "offsets": [ [ 125, 148 ] ], "normalized": [] }, { "id": "split_0_train_50005_entity", "type": "progene_text", "text": [ "asl" ], "offsets": [ [ 151, 154 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30783
split_0_train_30783
[ { "id": "split_0_train_30783_passage", "type": "progene_text", "text": [ "Eight and six introns were present in the ass and asl gene , respectively ." ], "offsets": [ [ 0, 75 ] ] } ]
[ { "id": "split_0_train_50006_entity", "type": "progene_text", "text": [ "ass" ], "offsets": [ [ 42, 45 ] ], "normalized": [] }, { "id": "split_0_train_50007_entity", "type": "progene_text", "text": [ "asl" ], "offsets": [ [ 50, 53 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30784
split_0_train_30784
[ { "id": "split_0_train_30784_passage", "type": "progene_text", "text": [ "The location of four introns in the asl gene were conserved among vertebrate asl genes ." ], "offsets": [ [ 0, 88 ] ] } ]
[ { "id": "split_0_train_50008_entity", "type": "progene_text", "text": [ "asl" ], "offsets": [ [ 36, 39 ] ], "normalized": [] }, { "id": "split_0_train_50009_entity", "type": "progene_text", "text": [ "asl" ], "offsets": [ [ 77, 80 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30785
split_0_train_30785
[ { "id": "split_0_train_30785_passage", "type": "progene_text", "text": [ "Deduced amino acid sequences , representing the first homobasidiomycete ASS and ASL protein sequences , were analysed and compared with their counterparts in other organisms ." ], "offsets": [ [ 0, 175 ] ] } ]
[ { "id": "split_0_train_50010_entity", "type": "progene_text", "text": [ "ASS" ], "offsets": [ [ 72, 75 ] ], "normalized": [] }, { "id": "split_0_train_50011_entity", "type": "progene_text", "text": [ "ASL" ], "offsets": [ [ 80, 83 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30786
split_0_train_30786
[ { "id": "split_0_train_30786_passage", "type": "progene_text", "text": [ "The ass ORF encoded for a protein of 425 amino acids with a calculated molecular mass of 47266Da ." ], "offsets": [ [ 0, 98 ] ] } ]
[ { "id": "split_0_train_50012_entity", "type": "progene_text", "text": [ "ass" ], "offsets": [ [ 4, 7 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30787
split_0_train_30787
[ { "id": "split_0_train_30787_passage", "type": "progene_text", "text": [ "An alignment with ASS proteins from other organisms revealed high similarity with fungal and mammalian ASS proteins , 61 - 63 % and 51 - 55 % identity , respectively ." ], "offsets": [ [ 0, 167 ] ] } ]
[ { "id": "split_0_train_50013_entity", "type": "progene_text", "text": [ "ASS" ], "offsets": [ [ 18, 21 ] ], "normalized": [] }, { "id": "split_0_train_50014_entity", "type": "progene_text", "text": [ "ASS" ], "offsets": [ [ 103, 106 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30788
split_0_train_30788
[ { "id": "split_0_train_30788_passage", "type": "progene_text", "text": [ "The asl open reading frame ( ORF ) encoded a protein of 464 amino acids with an calculated mass of 52337Da and similar to ASS shared the highest similarity with fungal ASL proteins , 59 - 60 % identity ." ], "offsets": [ [ 0, 203 ] ] } ]
[ { "id": "split_0_train_50015_entity", "type": "progene_text", "text": [ "asl" ], "offsets": [ [ 4, 7 ] ], "normalized": [] }, { "id": "split_0_train_50016_entity", "type": "progene_text", "text": [ "ASS" ], "offsets": [ [ 122, 125 ] ], "normalized": [] }, { "id": "split_0_train_50017_entity", "type": "progene_text", "text": [ "ASL" ], "offsets": [ [ 168, 171 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30789
split_0_train_30789
[ { "id": "split_0_train_30789_passage", "type": "progene_text", "text": [ "Northern analyses of ass and asl during fruiting body formation and post - harvest development revealed that expression was significantly up - regulated from developmental stage 3 on for all the tissues studied ." ], "offsets": [ [ 0, 212 ] ] } ]
[]
[]
[]
[]
split_0_train_30790
split_0_train_30790
[ { "id": "split_0_train_30790_passage", "type": "progene_text", "text": [ "The expression reached a maximum at the later stages of fruiting body growth , stages 6 and 7 ." ], "offsets": [ [ 0, 95 ] ] } ]
[]
[]
[]
[]
split_0_train_30791
split_0_train_30791
[ { "id": "split_0_train_30791_passage", "type": "progene_text", "text": [ "Both ass and asl genes were up - regulated within 3h after harvest showing that the induction mechanism is very sensitive to the harvest event and emphasizes the importance of the arginine biosynthetic pathway / ornithine cycle in post - harvest physiology ." ], "offsets": [ [ 0, 258 ] ] } ]
[ { "id": "split_0_train_50018_entity", "type": "progene_text", "text": [ "ass" ], "offsets": [ [ 5, 8 ] ], "normalized": [] }, { "id": "split_0_train_50019_entity", "type": "progene_text", "text": [ "asl" ], "offsets": [ [ 13, 16 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30792
split_0_train_30792
[ { "id": "split_0_train_30792_passage", "type": "progene_text", "text": [ "Expression of APP pathway mRNAs and proteins in Alzheimer 's disease ." ], "offsets": [ [ 0, 70 ] ] } ]
[ { "id": "split_0_train_50020_entity", "type": "progene_text", "text": [ "APP" ], "offsets": [ [ 14, 17 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30793
split_0_train_30793
[ { "id": "split_0_train_30793_passage", "type": "progene_text", "text": [ "In both trisomy 21 and rare cases of triplication of amyloid precursor protein ( APP ) Alzheimer 's disease ( AD ) pathological changes are believed to be secondary to increased expression of APP ." ], "offsets": [ [ 0, 197 ] ] } ]
[ { "id": "split_0_train_50021_entity", "type": "progene_text", "text": [ "amyloid precursor protein" ], "offsets": [ [ 53, 78 ] ], "normalized": [] }, { "id": "split_0_train_50022_entity", "type": "progene_text", "text": [ "APP" ], "offsets": [ [ 81, 84 ] ], "normalized": [] }, { "id": "split_0_train_50023_entity", "type": "progene_text", "text": [ "APP" ], "offsets": [ [ 192, 195 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30794
split_0_train_30794
[ { "id": "split_0_train_30794_passage", "type": "progene_text", "text": [ "We hypothesized that sporadic AD may also be associated with changes in transcription of APP or its metabolic partners ." ], "offsets": [ [ 0, 120 ] ] } ]
[ { "id": "split_0_train_50024_entity", "type": "progene_text", "text": [ "APP" ], "offsets": [ [ 89, 92 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30795
split_0_train_30795
[ { "id": "split_0_train_30795_passage", "type": "progene_text", "text": [ "To address this issue , temporal neocortex of 27 AD and 21 non - demented control brains was examined to assess mRNA levels of APP isoforms ( total APP , APP containing the Kunitz protease inhibitor domain [ APP-KPI ] and APP770 ) and APP metabolic enzymatic partners ( the APP cleaving enzymes beta-secretase [ BACE ] and presenilin-1 [ PS-1 ] , and putative clearance molecules , low - density lipoprotein receptor protein [ LRP ] and apolipoprotein E [ apoE ] ) ." ], "offsets": [ [ 0, 466 ] ] } ]
[ { "id": "split_0_train_50025_entity", "type": "progene_text", "text": [ "APP" ], "offsets": [ [ 127, 130 ] ], "normalized": [] }, { "id": "split_0_train_50026_entity", "type": "progene_text", "text": [ "APP" ], "offsets": [ [ 148, 151 ] ], "normalized": [] }, { "id": "split_0_train_50027_entity", "type": "progene_text", "text": [ "APP" ], "offsets": [ [ 154, 157 ] ], "normalized": [] }, { "id": "split_0_train_50028_entity", "type": "progene_text", "text": [ "APP-KPI" ], "offsets": [ [ 208, 215 ] ], "normalized": [] }, { "id": "split_0_train_50029_entity", "type": "progene_text", "text": [ "APP770" ], "offsets": [ [ 222, 228 ] ], "normalized": [] }, { "id": "split_0_train_50030_entity", "type": "progene_text", "text": [ "APP" ], "offsets": [ [ 235, 238 ] ], "normalized": [] }, { "id": "split_0_train_50031_entity", "type": "progene_text", "text": [ "APP" ], "offsets": [ [ 274, 277 ] ], "normalized": [] }, { "id": "split_0_train_50032_entity", "type": "progene_text", "text": [ "beta-secretase" ], "offsets": [ [ 295, 309 ] ], "normalized": [] }, { "id": "split_0_train_50033_entity", "type": "progene_text", "text": [ "BACE" ], "offsets": [ [ 312, 316 ] ], "normalized": [] }, { "id": "split_0_train_50034_entity", "type": "progene_text", "text": [ "presenilin-1" ], "offsets": [ [ 323, 335 ] ], "normalized": [] }, { "id": "split_0_train_50035_entity", "type": "progene_text", "text": [ "PS-1" ], "offsets": [ [ 338, 342 ] ], "normalized": [] }, { "id": "split_0_train_50036_entity", "type": "progene_text", "text": [ "low - density lipoprotein receptor" ], "offsets": [ [ 382, 416 ] ], "normalized": [] }, { "id": "split_0_train_50037_entity", "type": "progene_text", "text": [ "LRP" ], "offsets": [ [ 427, 430 ] ], "normalized": [] }, { "id": "split_0_train_50038_entity", "type": "progene_text", "text": [ "apolipoprotein E" ], "offsets": [ [ 437, 453 ] ], "normalized": [] }, { "id": "split_0_train_50039_entity", "type": "progene_text", "text": [ "apoE" ], "offsets": [ [ 456, 460 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30796
split_0_train_30796
[ { "id": "split_0_train_30796_passage", "type": "progene_text", "text": [ "Furthermore , we evaluated how changes in APP at the mRNA level affect the amount of Tris buffer extractable APP protein and Abeta40 and 42 peptides in AD and control brains ." ], "offsets": [ [ 0, 175 ] ] } ]
[ { "id": "split_0_train_50040_entity", "type": "progene_text", "text": [ "APP" ], "offsets": [ [ 42, 45 ] ], "normalized": [] }, { "id": "split_0_train_50041_entity", "type": "progene_text", "text": [ "APP" ], "offsets": [ [ 109, 112 ] ], "normalized": [] }, { "id": "split_0_train_50042_entity", "type": "progene_text", "text": [ "Abeta40" ], "offsets": [ [ 125, 132 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30797
split_0_train_30797
[ { "id": "split_0_train_30797_passage", "type": "progene_text", "text": [ "As assessed by quantitative PCR , APP - KPI ( p = 0.007 ) , APP770 ( p = 0.004 ) , PS-1 ( p = 0.004 ) , LRP ( p = 0.003 ) , apoE ( p = 0.0002 ) and GFAP ( p < 0.0001 ) mRNA levels all increased in AD , and there was a shift from APP695 ( a neuronal isoform ) towards KPI containing isoforms that are present in glia as well ." ], "offsets": [ [ 0, 325 ] ] } ]
[ { "id": "split_0_train_50043_entity", "type": "progene_text", "text": [ "APP" ], "offsets": [ [ 34, 37 ] ], "normalized": [] }, { "id": "split_0_train_50044_entity", "type": "progene_text", "text": [ "APP770" ], "offsets": [ [ 60, 66 ] ], "normalized": [] }, { "id": "split_0_train_50045_entity", "type": "progene_text", "text": [ "PS-1" ], "offsets": [ [ 83, 87 ] ], "normalized": [] }, { "id": "split_0_train_50046_entity", "type": "progene_text", "text": [ "LRP" ], "offsets": [ [ 104, 107 ] ], "normalized": [] }, { "id": "split_0_train_50047_entity", "type": "progene_text", "text": [ "apoE" ], "offsets": [ [ 124, 128 ] ], "normalized": [] }, { "id": "split_0_train_50048_entity", "type": "progene_text", "text": [ "GFAP" ], "offsets": [ [ 148, 152 ] ], "normalized": [] }, { "id": "split_0_train_50049_entity", "type": "progene_text", "text": [ "APP695" ], "offsets": [ [ 229, 235 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30798
split_0_train_30798
[ { "id": "split_0_train_30798_passage", "type": "progene_text", "text": [ "APP-KPI mRNA levels correlated with soluble APPalpha - KPI protein ( sAPPalpha-KPI ) levels measured by ELISA ( tau = 0.33 , p = 0.015 by Kendall 's rank correlation ) ; in turn , soluble APPalpha - KPI protein levels positively correlated with Tris - extractable , soluble Abeta40 ( p = 0.046 ) and 42 levels ( p = 0.007 ) ." ], "offsets": [ [ 0, 325 ] ] } ]
[ { "id": "split_0_train_50050_entity", "type": "progene_text", "text": [ "APP-KPI" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "split_0_train_50051_entity", "type": "progene_text", "text": [ "APPalpha" ], "offsets": [ [ 44, 52 ] ], "normalized": [] }, { "id": "split_0_train_50052_entity", "type": "progene_text", "text": [ "sAPPalpha-KPI" ], "offsets": [ [ 69, 82 ] ], "normalized": [] }, { "id": "split_0_train_50053_entity", "type": "progene_text", "text": [ "APPalpha" ], "offsets": [ [ 188, 196 ] ], "normalized": [] }, { "id": "split_0_train_50054_entity", "type": "progene_text", "text": [ "Abeta40" ], "offsets": [ [ 274, 281 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_30799
split_0_train_30799
[ { "id": "split_0_train_30799_passage", "type": "progene_text", "text": [ "The ratio of soluble APPalpha - KPI protein levels to total APP protein increased in AD , and also correlated with GFAP protein levels in AD ." ], "offsets": [ [ 0, 142 ] ] } ]
[ { "id": "split_0_train_50055_entity", "type": "progene_text", "text": [ "APPalpha" ], "offsets": [ [ 21, 29 ] ], "normalized": [] }, { "id": "split_0_train_50056_entity", "type": "progene_text", "text": [ "APP" ], "offsets": [ [ 60, 63 ] ], "normalized": [] }, { "id": "split_0_train_50057_entity", "type": "progene_text", "text": [ "GFAP" ], "offsets": [ [ 115, 119 ] ], "normalized": [] } ]
[]
[]
[]