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Additional resources and interventions may be important in this population. | Certain existing drugs might help fight the illness. | 2 |
Additional resources and interventions may be important in this population. | Additional research is needed in this area. | 1 |
Additional resources and interventions may be important in this population. | Additional research is warranted to confirm the results of this study in other samples and populations. | 2 |
Additional resources and interventions may be important in this population. | The causal assumptions require further prospective or longitudinal studies on the topic. | 2 |
Alcohol may have a direct impact on sperm quality, they say. | Heavy alcohol intake at ages 15-19 was not associated with overall prostate cancer; however, consumption of at least seven drinks per week during this age was associated with 3.2 times the odds of high-grade prostate cancer compared with non-drinkers. | 1 |
The DNA methylation changes ranged from 1–16%, and 407 methylation sites correlated with gene expression. | Silent locus identity is similarly lost in mutants for the cytosine maintenance methyltransferase, MET1. | 2 |
Sexually active male students who have sex with men are both less likely to use a condom and more likely to have had sex with four or more partners during their lifetime than male students who had sex with only women. | as compared with women who indicated they were taught. | 2 |
Sexually active male students who have sex with men are both less likely to use a condom and more likely to have had sex with four or more partners during their lifetime than male students who had sex with only women. | The rate was higher, although not significantly, in males (43.3%) than in females (27.1%), but it did not correlate to the age of the patients. | 1 |
Sexually active male students who have sex with men are both less likely to use a condom and more likely to have had sex with four or more partners during their lifetime than male students who had sex with only women. | Participants with a greater number of sexual or oral sexual partners were more likely to be hr-hpv positive. | 2 |
Sexually active male students who have sex with men are both less likely to use a condom and more likely to have had sex with four or more partners during their lifetime than male students who had sex with only women. | Girls are more likely than boys to think sexting would hurt their chances of getting a job. | 2 |
Sexually active male students who have sex with men are both less likely to use a condom and more likely to have had sex with four or more partners during their lifetime than male students who had sex with only women. | Societal factors influence the gender differences. | 2 |
Sexually active male students who have sex with men are both less likely to use a condom and more likely to have had sex with four or more partners during their lifetime than male students who had sex with only women. | There is no statistically significant difference in the sexual behavior between people who are living in the sub-african countries receiving funds from united states for abstinence education and people living in countries that do not receive any funds at all. | 2 |
The largest physician organizations incurred expenditures per patient 9.2% (95% CI, 3.8% to 15.0%, P = .001) | Per-patient expenditures increased 85 percent more slowly when the patient was enrolled in an aco as opposed to a traditional fee-for-service model. | 2 |
Unobscured star formation rates estimated from CLASH UV images using the Kennicutt relation range up to 80 in the most extended and highly structured systems. | These candidate clusters of dusty galaxies experience a contemporaneous bursts of star formation. | 2 |
The effects of temperature on insect metabolism and demographics were fairly consistent across insect species, including pest species such as aphids and corn borers. | When added to insect diet at concentrations similar to those found in potato leaves, chlorogenic acid, α-solanine, and α-chaconine all reduced S. exigua larval growth. | 2 |
Knockdown of ERBB4 caused a decrease in AKT phosphorylation in resistant cells but not in sensitive cells, suggesting that ERBB4 activat... | In contrast, long-term E 2 treatment resulted in the downregulation of ERα and p44/42 MAP kinase and upregulation of MMP-9 only, but no changes in c-ErbB2. | 1 |
Our findings provide an empirical basis for the refinement and review of pediatric Phase I trials, and for communication about their risk and benefit. | P = .06) but no apparent benefit for patients with Child-Pugh scores of 6 or 7 and 8. | 2 |
In addition, we demonstrate a robust maternal-placental-fetal inflammatory response following ZIKV infection. | This might explain why newborns are particularly sensitive to neonatal HSV infections. | 1 |
There was a substantial increase in the number of reported suicide attempts between 2009 and 2011, and more people reported having suicidal thoughts. | We estimate that the Great Recession is associated with at least 10 000 additional economic suicides between 2008 and 2010. | 2 |
There was a substantial increase in the number of reported suicide attempts between 2009 and 2011, and more people reported having suicidal thoughts. | While there is no connection between the two, one of three male teens who experienced sexual assault had attempted suicide in the previous year. | 2 |
A combination of two immunotherapies (oncolytic viruses and checkpoint inhibitors) could be much more successful in treating breast cancer and possibly other cancers. | M3-9-m (mhc i high) but not 76-9 (mhc i low) tumors respond to oncolytic herpes simplex virus-1 (ohsv-1) and pd-1 blockade combination therapy. | 1 |
Bisphosphonates may have less benefit in patients given chemotherapy, possibly because that therapy already prevents many recurrences. | With a median follow-up of 36.7 months, the median overall survival from the date of the first randomization was not significantly different between chemotherapy at 16.5 months (95% CI, 14.5-18.5 months) and chemoradiotherapy at 15.2 months (95% CI, 13.9-17.3 | 1 |
Food insecurity was associated with poor glucose control (OR=2·23; 95 % CI 1·22, 4·10); coping strategies that were more common among the food insecure were not associated with poor glucose control. | Fasting glucose did not significantly improve in the health education group. | 2 |
Our observations of decreased mean arterial pressure and reduced arterial stiffness following pregnancy suggest a significant favorable effect of pregnancy on maternal cardiovascular remodeling. | This may indicate an androgen influence on the pathophysiologic mechanism of preeclampsia. | 2 |
Our observations of decreased mean arterial pressure and reduced arterial stiffness following pregnancy suggest a significant favorable effect of pregnancy on maternal cardiovascular remodeling. | Pregnancy is a crucial period during which exposure to stress can negatively affect the health of both mother and baby. | 2 |
Providing women with an estimate of their risk for breast cancer would provide an opportunity for them to consider options to decrease their risk. | The evidence suggest this group is worthy of special focus when diagnosing and treating breast cancer. | 2 |
Providing women with an estimate of their risk for breast cancer would provide an opportunity for them to consider options to decrease their risk. | Doctors who have had cancer themselves, or experienced cancer with a family member, close friend, or coworker, are 17 percent more likely than those without personal cancer experience to act against established guidelines to recommend that low-risk women receive ovarian cancer screening. | 2 |
Providing women with an estimate of their risk for breast cancer would provide an opportunity for them to consider options to decrease their risk. | Certain types of diabetes drugs can help to decrease the risk of cancer in female patients with type 2 diabetes by up to 32 percent. | 2 |
Providing women with an estimate of their risk for breast cancer would provide an opportunity for them to consider options to decrease their risk. | Hormonal contraceptives prevented 21 percent of ovarian cancers in the participants. | 2 |
Providing women with an estimate of their risk for breast cancer would provide an opportunity for them to consider options to decrease their risk. | This difference cannot be blamed solely on genetics, says study coauthor marc hurlbert, executive director of the avon breast cancer crusade. | 1 |
The group they tested -- mostly health-care professionals and researchers living in the u.s. | Additional research is warranted to confirm the results of this study in other samples and populations. | 2 |
48 (38%) of 125 children in the ART-Def group, 32 (25%) of 126 in the ART-40W group, and 26 (21%) of 126 in the ART-96W group reached the primary endpoint. | P = .06) but no apparent benefit for patients with Child-Pugh scores of 6 or 7 and 8. | 2 |
We contribute in this regard by providing a conceptual basis for the eventual elaboration of such a unified theoretical approach. | In particular, we can say something about how complexity will arise in space. | 2 |
Certain existing drugs might help fight the illness. | An experimental drug may hold promise as a potential treatment. | 2 |
Those who were given testosterone were at the edge of believing that they were on a winning streak, while those who were administered cortisol took riskier decisions. | This effect was more apparent in men than in women who had higher cortisol levels in the awakening period. | 2 |
Those who were given testosterone were at the edge of believing that they were on a winning streak, while those who were administered cortisol took riskier decisions. | Testosterone needs to act not just on one primary area but throughout the brain in order to best regulate how a male bird carries off his part of the complex choreography of attracting a mate. | 2 |
Those who were given testosterone were at the edge of believing that they were on a winning streak, while those who were administered cortisol took riskier decisions. | Although the testosterone did not help the women solve more tasks, it did help them have a better knowledge of the maze layout. | 2 |
Marine reserves have the potential to build community resilience through mechanisms that promote species and functional stability, and resist colonisation by warm water vagrants. | If nourishment is not a long-run strategy to manage eroding coastlines, a gradual removal is more likely to smooth the transition to more climate-resilient coastal communities. | 2 |
Marine reserves have the potential to build community resilience through mechanisms that promote species and functional stability, and resist colonisation by warm water vagrants. | The reduction in lionfish numbers at some marine sites have led to the recovery of native fish species. | 2 |
Marine reserves have the potential to build community resilience through mechanisms that promote species and functional stability, and resist colonisation by warm water vagrants. | There are still many gaps in our knowledge of effects of climate change on biodiversity. | 1 |
For screening, the average referral-to-diagnostic imaging time was 22.5 days for the teleophthalmology group and 18 days for the routine care group. | Seven of 375 (1.9%) of the patients required a repeat ct examination with oral contrast within seven days of their initial scan, although none of these patients required a change in the course of their management following the scan with the oral contrast. | 2 |
Ecological niche modeling indicated that changing climate most likely played a role in the decline of the Sumatran rhinoceros, as less suitable habitat on an emergent Sundaland corridor isolated Sumatran rhinoceros populations. | Under the current climate, statistical restrictions on species distribution modelling means that important sites for narrow-ranging and threatened species are systematically down-played. | 2 |
Ecological niche modeling indicated that changing climate most likely played a role in the decline of the Sumatran rhinoceros, as less suitable habitat on an emergent Sundaland corridor isolated Sumatran rhinoceros populations. | There are still many gaps in our knowledge of effects of climate change on biodiversity. | 1 |
Those who survived felt grief for a former life. | These experiences were rated as among the most personally meaningful and spiritually significant lifetime experiences, with moderate to strong persisting positive changes in life satisfaction, purpose, and meaning attributed to these experiences. | 2 |
This genome content variation, as well as loss-of-function variation in the form of premature stop codons and frameshifting indels, is heavily enriched in the subtelomeres, strongly reinforcing the relevance of these regions to functional evolution. | The relatively simple genomic architecture of species differences facilitates the evolution of linkage disequilibrium in the presence of gene flow. | 2 |
Acts of violence are influenced by multiple factors, often acting together. | Perpetrators of sexual violence typically hold hostile attitudes about women and sex. | 2 |
High weight gain was more strongly linked with preeclampsia developing after 37 weeks of pregnancy than with more severe forms of preeclampsia that develop earlier in pregnancy, hutcheon said. | Babies with high birth weight were almost twice as likely to be obese than babies born at an average birth weight, according to united press international. | 2 |
High weight gain was more strongly linked with preeclampsia developing after 37 weeks of pregnancy than with more severe forms of preeclampsia that develop earlier in pregnancy, hutcheon said. | This may indicate an androgen influence on the pathophysiologic mechanism of preeclampsia. | 2 |
High weight gain was more strongly linked with preeclampsia developing after 37 weeks of pregnancy than with more severe forms of preeclampsia that develop earlier in pregnancy, hutcheon said. | Preeclampsia is not in fact a single disease caused solely by genetic factors. | 1 |
A 24-hour recall was as good as the FFQ in placing individuals in the distribution of habitual diet from weighed records. | When you eat might be almost as important as what you eat. | 1 |
When the biological clocks of cyanobacteria (blue-green algae) were stopped in their daylight setting, the amount of several biomolecules that they were genetically altered to produce increased by as much as 700 percent when grown in constant light. | Although some chemical reactions still go on in the dark, hydrogen cyanide and hydrogen sulphite ions in water only give rise to the building blocks of life when exposed to uv light. | 2 |
17.1, 11.4 and 4.4 s for treatments 4wk, 2wk, 1wk and control; P P P P | Assuming 50% 14-d survival in the population treated with the current standard of supportive care, all designs had similar probabilities of identifying effective treatments correctly, while the MSA was less likely to recommend treatments that were ineffective. | 2 |
17.1, 11.4 and 4.4 s for treatments 4wk, 2wk, 1wk and control; P P P P | At database lock and based on 92 deaths, no difference in overall survival was noted between linsitinib and placebo (median 323 days [95% CI 256–507] vs 356 days [249–556]; hazard ratio 0·94 [95% CI 0·61–1·44]; p=0·77). | 2 |
17.1, 11.4 and 4.4 s for treatments 4wk, 2wk, 1wk and control; P P P P | With a median follow-up of 36.7 months, the median overall survival from the date of the first randomization was not significantly different between chemotherapy at 16.5 months (95% CI, 14.5-18.5 months) and chemoradiotherapy at 15.2 months (95% CI, 13.9-17.3 | 2 |
17.1, 11.4 and 4.4 s for treatments 4wk, 2wk, 1wk and control; P P P P | Median docetaxel PFS for gDDRm+ (6.8 mo) was not significantly different from that for gDDRm– (5.1 mo), and RRs were similar (gDDRm+=61%; gDDRm–=54%). | 2 |
17.1, 11.4 and 4.4 s for treatments 4wk, 2wk, 1wk and control; P P P P | At acute HA, Post p-mTORSer2448 and Post and REC p-p70S6KSer424/421 were not different from Base and lower than SL (P < 0.05... | 2 |
Neighborhoods in which whites and blacks live alongside hispanics, asians or both are showing up in large numbers in each type of metropolitan center, throughout the country, in urban areas with different histories and combinations of populations. | Their initial report for the period through 1990 offered the caveats that the decline was more limited in large cities of the Northeast and Midwest and that “there are more completely black areas in our cities than there have ever been in the past, and large amounts of segregation linger” (Cutler, Glaeser and Vigdor 1999, p. 496). | 2 |
Moreover, changes in neuronal morphology correlated with a 40% decrease in the levels of BDNF mRNA and mature protein in the brain, but not in TrkB. | Results of established test methods with animal models and cell lines used up until now can hardly be translated to the processes in the human brain. | 1 |
Genetically modifying the human genome could eventually be useful. | Additionally, advanced techniques to affect targeted genome modifi- cations are emerging, and it is not clear whether these will be encompassed by the current GE process-based trigger for regulatory oversight. | 1 |
Genetically modifying the human genome could eventually be useful. | An experimental drug may hold promise as a potential treatment. | 2 |
Approximately 100 sites have observed minimum surface temperatures of ~−98 °C during the winters of 2004–2016. | Persistently shadowed craters are likely to harbor ice. | 2 |
Based on the pooled maximally adjusted effect sizes using random-effects models, a small but significant association was found for ARHL within all domains of cognitive function. | For the entire sample, there were no differences in symptom trajectories between study arms; mean differences in change scores at 12 months were –0.14 (95% confidence interval –0.34 to 0.07) for inattention; –0.13 (–0.31 to 0.05) for hyperactivity/impulsivity; –0.09 (–0.28 to 0.11) for oppositionality; and 3.30 (–1.23 to 7.82) for social skills. | 1 |
Findings indicated that bullying victimization significantly predicted greater levels of depression, anxiety, and post-traumatic stress (PTS) after controlling for other childhood victimization experiences. | Being bullied increases the risk of sleep disorders called parasomnias, which are related to nightmares, night terrors or sleep-walking. | 2 |
Findings indicated that bullying victimization significantly predicted greater levels of depression, anxiety, and post-traumatic stress (PTS) after controlling for other childhood victimization experiences. | Bully-victims are perhaps the most vulnerable group of all. | 2 |
Historical warming has increased the severity and probability of the hottest month and hottest day of the year at >80% of the available observational area. | Accelerated warming decades are characterized by rapid warming of globally averaged surface air temperature, greater increases of heat content in the upper ocean layers, an... | 2 |
Historical warming has increased the severity and probability of the hottest month and hottest day of the year at >80% of the available observational area. | The trend matches neatly with models of human-influenced global warming, and thus cannot be attributed to natural variability. | 2 |
Historical warming has increased the severity and probability of the hottest month and hottest day of the year at >80% of the available observational area. | Limiting the global mean temperature increase to 1.5deg celsius is neither a geophysical impossibility, nor a technical fantasy. | 2 |
Their discharges may be increasing because of an intensifying hydrological cycle driven by warming climate. | In the northern high plains, groundwater levels either have been holding relatively steady or have increased between 1950 and 2007 - fed by rain and seepage from lakes that come and go with the rainy season and snow melt. | 2 |
These various reproductive factors are the cause of the reduction in risk that has been seen. | Abstinence from vaginal sex significantly increased from 10% at baseline to 34% at 6 months (p <.01) and abstinence from oral sex increased from 25% to 80% (p <.01). | 2 |
These various reproductive factors are the cause of the reduction in risk that has been seen. | Further study is warranted to elucidate the factors accounting for different outcomes in females and males. | 0 |
78% of these drug-like compounds in the library underwent successful coupling, suggesting that their protocol would find broad applicability in a medicinal chemistry setting. | An experimental drug may hold promise as a potential treatment. | 2 |
Various bifurcation branches on a plane of normalized longest-admissible wavelength versus compressive strain delineate different phases of corrugated surface configurations to form a ruga phase diagram. | Macroscopic measures of pressure and shear stress exhibit limit cycle behavior with respect to the applied cyclic strain. | 2 |
Training-induced brain plasticity continues through chronic phases of tbi and that brain connectivity and cortical thickness may serve as markers of plasticity. | Ect directly enhances gray matter and appears to encourage brain plasticity.1. | 2 |
Training-induced brain plasticity continues through chronic phases of tbi and that brain connectivity and cortical thickness may serve as markers of plasticity. | Additional research is required to understand the influence of exercise programs on a variety of cognitive functions. | 1 |
Silent locus identity is similarly lost in mutants for the cytosine maintenance methyltransferase, MET1. | Expression of a putative methyltransferase, mettl7a1, is associated with the successful reprogramming trajectory; adding mettl7a1 to the reprogramming cocktail increases the yield of induced endoderm progenitors. | 2 |
Verbal placements may be processed more deeply than visual ones. | The same is true for how the brain understands the environments around us. | 1 |
Using technology was linked to some positive outcomes: on days when adolescents spent more time using digital technologies they were less likely to report symptoms of depression and anxiety. | Parents underestimate how often their children engage in risky online behavior, like cyberbullying and viewing pornography. | 2 |
, across sub-saharan africa, the amount of land experiencing a net drop in carbon density was larger than the amount of land experiencing net gains. | The amazon carbon sink has accumulated carbon at a slower rate in recent years. | 2 |
Many diagnoses established with ct scans cause more problems than they solve. | It should be noted that this retrospective study may underreport the true incidence of complications among these patients. | 1 |
Many diagnoses established with ct scans cause more problems than they solve. | While the rates of diagnostic ct did increase substantially during that time period, the changes varied considerably according to age group and anatomical region. | 2 |
Many diagnoses established with ct scans cause more problems than they solve. | Further investigations are warranted into the risk factors and treatment of AI-induced CTS. | 2 |
Many diagnoses established with ct scans cause more problems than they solve. | Seven of 375 (1.9%) of the patients required a repeat ct examination with oral contrast within seven days of their initial scan, although none of these patients required a change in the course of their management following the scan with the oral contrast. | 2 |
The serpentinization of the upper mantle, observed in the tethyan rocks of calabria, may have been important in weakening the oceanic lithosphere at the continental margin. | These bathymetric features are continental fragments rather than igneous plateaus related to broken ridge. | 1 |
The icy corridor is currently eroding, potentially unveiling the presence of ice and organic strata. | Persistently shadowed craters are likely to harbor ice. | 2 |
Gut bacteria may be affecting our eating decisions in part by acting through the vagus nerve, which connects 100 million nerve cells from the digestive tract to the base of the brain. | We have recently demonstrated that prebiotics (soluble fibres that augment the growth of indigenous microbiota) have significant neurobiological effects in rats, but their action in humans has not been reported. | 1 |
as compared with women who indicated they were taught. | Societal factors influence the gender differences. | 2 |
Assuming 50% 14-d survival in the population treated with the current standard of supportive care, all designs had similar probabilities of identifying effective treatments correctly, while the MSA was less likely to recommend treatments that were ineffective. | With a median follow-up of 36.7 months, the median overall survival from the date of the first randomization was not significantly different between chemotherapy at 16.5 months (95% CI, 14.5-18.5 months) and chemoradiotherapy at 15.2 months (95% CI, 13.9-17.3 | 2 |
Of those genes that drive cancer processes, some may function by acting on the primary tumor—causing rise of metastatic lesions—or at the metastatic site to promote colonization, survival, and incorporation of surrounding stroma. | Two different types of cells, known as basal and luminal, represented potential progenitor cells and, with varying degrees of aggressiveness, could initiate prostate cancer. | 2 |
Of those genes that drive cancer processes, some may function by acting on the primary tumor—causing rise of metastatic lesions—or at the metastatic site to promote colonization, survival, and incorporation of surrounding stroma. | Not all human tumors express all members of the src family, and that expression of yes and lyn differed among tumors. | 1 |
Muscle strength declined more quickly than bone density and may require continued participation in a supervised exercise program where the degree of effort can be sustained at a higher level. | From baseline to week RT12, whole body muscle mass and protein-mineral mass were not changed, fat-free mass (P= 0.004) and total body water (P= 0.013) were decreased, and percentage body fat was increased (P= 0.011) in these weight-stable older people, independent of group assignment. | 1 |
Twenty-two percent of physicians reported low confidence in their genomic knowledge. | Doctors who have had cancer themselves, or experienced cancer with a family member, close friend, or coworker, are 17 percent more likely than those without personal cancer experience to act against established guidelines to recommend that low-risk women receive ovarian cancer screening. | 2 |
Twenty-two percent of physicians reported low confidence in their genomic knowledge. | Nearly 40 percent of microbe-disease associations involve a species that did not previously have a genome. | 2 |
AMPKα activity (pAMPKα) was decreased, while protein expression of collagen I and RUNX2 was increased in the aortic valves of KL+/− mice fed with a HFD. | In contrast, pharmacologic or genetic activation of HIF via HIF prolyl-hydroxylase inhibition protected wild-type animals from ischemic kidney injury and inflammation; however, these same protective effects were not observed in HIF prolyl-hydroxylase inhibitor–treated animals lacking endothelial HIF-2. | 2 |
The ancient super-continent pangaea may have broken apart more slowly than scientists previously thought. | Plate tectonics may have fueled an increase in oxygen between 1.5 billion and half a billion years ago. | 2 |
Allogeneic hematopoietic stem cell transplantation can reduce cancer recurrence and, therefore, improve overall survival for patients with aml. | Novel therapies are needed to improve the outcomes of patients with aml who harbor this particular gene mutation. | 2 |
This dentary might pertain to Galleonosaurus dorisae n. gen. | The morphology of the preserved regions of the cranium, and especially that of the facial skeleton, indicates that the fossil belongs to the Neanderthal clade. | 1 |
A 5-year higher Δage is associated with a 21% higher mortality risk, adjusting for age and sex. | The rate was higher, although not significantly, in males (43.3%) than in females (27.1%), but it did not correlate to the age of the patients. | 2 |
A 5-year higher Δage is associated with a 21% higher mortality risk, adjusting for age and sex. | Further study is warranted to elucidate the factors accounting for different outcomes in females and males. | 1 |
Heart function improves only after quitting. | Healthy nonsmokers experienced increased adrenaline levels in their heart after one electronic cigarette (e-cigarette) with nicotine but there were no increased adrenaline levels when the study subjects used an a nicotine-free or empty e-cig. | 2 |
Neither drug at either dose functioned as a reinforcer, as measured by the Multiple Choice Procedure. | However, as single agents, these drugs had little effect on clonogenic potential. | 2 |