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Neither drug at either dose functioned as a reinforcer, as measured by the Multiple Choice Procedure.
No statistically significant differences in QoL were found (one RCT).
2
Neither drug at either dose functioned as a reinforcer, as measured by the Multiple Choice Procedure.
Psychometric properties did not differ on the basis of study quality, sample type (clinical vs. nonclinical) or sample age (child vs. adolescent).
2
First, obesity may be related to hypersensitivity to interoceptive signals of hunger, leading to positive alliesthesia for food cues that undermine attempts to change unhealthy eating behaviors.
The mechanisms by which reductions in plasma leptin concentrations stimulate food intake are not limited to the brain, as previously thought.
2
Most remarkably, early-life exposure may be related to increased risks for several types of cancer and other diseases during adulthood.
Minimising exposure may be disadvantageous by increasing the risk of prevalent conditions related to cardiovascular disease.
2
Most remarkably, early-life exposure may be related to increased risks for several types of cancer and other diseases during adulthood.
Tissue damage may result directly from pollutant toxicity because fine and ultrafine particles can gain access to organs, or indirectly through systemic inflammatory processes.
2
Most remarkably, early-life exposure may be related to increased risks for several types of cancer and other diseases during adulthood.
We need to tease out the mechanisms by which copd may increase lung cancer risk in smokers, and to conduct clinical trials to determine whether treating copd in former and current smokers lessens that risk,aeur said david christiani, elkan blout professor of environmental genetics at harvard chan school and senior author of the study.
2
Most remarkably, early-life exposure may be related to increased risks for several types of cancer and other diseases during adulthood.
Heavy alcohol intake at ages 15-19 was not associated with overall prostate cancer; however, consumption of at least seven drinks per week during this age was associated with 3.2 times the odds of high-grade prostate cancer compared with non-drinkers.
1
Most remarkably, early-life exposure may be related to increased risks for several types of cancer and other diseases during adulthood.
Recent advances in the measurement of exposure biomarkers hold much promise in improving the epidemiological data, but their utility must be understood to facilitate appropriate study design.
1
Most remarkably, early-life exposure may be related to increased risks for several types of cancer and other diseases during adulthood.
Because suitable biomarkers of long-term exposure do not exist for many common FRs, and levels of FRs in dust are significantly correlated with exposure, relationships between FRs in household dust and PTC were evaluated in addition to available biomarkers.
1
These results implicate a primed and immune-reactive microglial population as a possible triggering mechanism for the development of depressive complications after TBI.
Gal3-dependent-tlr4 activation could contribute to sustained microglia activation, prolonging the inflammatory response in the brain.
2
Ect directly enhances gray matter and appears to encourage brain plasticity.1.
Memory decline can be improved through electrical pulses.
2
The rate was higher, although not significantly, in males (43.3%) than in females (27.1%), but it did not correlate to the age of the patients.
Societal factors influence the gender differences.
1
The rate was higher, although not significantly, in males (43.3%) than in females (27.1%), but it did not correlate to the age of the patients.
It should be noted that this retrospective study may underreport the true incidence of complications among these patients.
2
The rate was higher, although not significantly, in males (43.3%) than in females (27.1%), but it did not correlate to the age of the patients.
Further study is warranted to elucidate the factors accounting for different outcomes in females and males.
1
The rate was higher, although not significantly, in males (43.3%) than in females (27.1%), but it did not correlate to the age of the patients.
There was no difference in mammography utilization between Asians/Pacific Islanders and whites (OR = 1.82; 95% CI, 0.09-38.41).
1
The rate was higher, although not significantly, in males (43.3%) than in females (27.1%), but it did not correlate to the age of the patients.
There was evidence that the association was not significantly altered by stage of liver disease or the presence/absence of high alcohol consumption, high body mass index, type 2 diabetes mellitus, smoking, or hepatitis B and C viruses.
1
The rate was higher, although not significantly, in males (43.3%) than in females (27.1%), but it did not correlate to the age of the patients.
This difference cannot be blamed solely on genetics, says study coauthor marc hurlbert, executive director of the avon breast cancer crusade.
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Doctors who have had cancer themselves, or experienced cancer with a family member, close friend, or coworker, are 17 percent more likely than those without personal cancer experience to act against established guidelines to recommend that low-risk women receive ovarian cancer screening.
Hormonal contraceptives prevented 21 percent of ovarian cancers in the participants.
2
Doctors who have had cancer themselves, or experienced cancer with a family member, close friend, or coworker, are 17 percent more likely than those without personal cancer experience to act against established guidelines to recommend that low-risk women receive ovarian cancer screening.
It is premature to issue a pco meant to apply to a general population of patients with cancer.
2
Participants with a greater number of sexual or oral sexual partners were more likely to be hr-hpv positive.
Abstinence from vaginal sex significantly increased from 10% at baseline to 34% at 6 months (p <.01) and abstinence from oral sex increased from 25% to 80% (p <.01).
2
In the PanCan data set, 1871 persons had 7008 nodules, of which 102 were malignant, and in the BCCA data set, 1090 persons had 5021 nodules, of which 42 were malignant.
There were no statistically significant differences between the dominant tumor nodule volume and total tumor volum...
2
These candidate clusters of dusty galaxies experience a contemporaneous bursts of star formation.
The proximity between potentially habitable terrestrial planets may enable the onset of widespread interstellar panspermia near the nuclei of galaxies.
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These candidate clusters of dusty galaxies experience a contemporaneous bursts of star formation.
Our dynamical results convincingly demonstrate that M67 could not have been the birth cluster of our solar system.«
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First human settlers in north america were of asian descent and not of western europe origin.
They are not exclusive descendants of east asians but also of west eurasians.
2
Aerobic exercise trimmed visceral fat more effectively than strength training, although most of the exercise trials were small-scale and had no placebo control.
Neither bmi nor waist circumference nor percentage of body fat affected mortality rates when fitness was considered.
1
Aerobic exercise trimmed visceral fat more effectively than strength training, although most of the exercise trials were small-scale and had no placebo control.
Such programs have achieved modest but significant results in helping participants lose weight.
1
Aerobic exercise trimmed visceral fat more effectively than strength training, although most of the exercise trials were small-scale and had no placebo control.
There was no significant group difference in total change in adiposity, but abdominal adiposity decreased more (P = 0.049) in the capsinoid group (−1.11 ± 1.83%) than in the placebo group (−0.18 ± 1.94%), and this change correlated with the change in body weight (r = 0.46, P < 0.0001).
1
Jnj-63533054 was particularly effective at decreasing drinking in one subgroup of animals--those that had the highest alcohol intake and showed compulsive drinking behavior.
The effects on consumption may therefore represent a lower bound of efficacy of “ultra-brief” mindfulness instructions in hazardous drinkers, at least at short follow-up intervals.
1
Local relief of 3–5 km at massifs, troughs and pits supports conclusions that the icy shell of Pluto is relatively rigid.
2003 UB313 is likely to undergo substantial seasonal change over the large range of heliocentric distances that it travels; at its current distance, Pluto is likely to prove a useful analog for better understanding the range of seasonal changes on this body.
2
Local relief of 3–5 km at massifs, troughs and pits supports conclusions that the icy shell of Pluto is relatively rigid.
If there is no gas hydrate insulating layer, the liquid oceans on pluto would have been completely frozen hundreds of millions of years ago.
2
In addition to driving autoantibody production, TLR7 engagement is likely to contribute to the pathogenesis of inflammatory disease in lupus.
Gal3-dependent-tlr4 activation could contribute to sustained microglia activation, prolonging the inflammatory response in the brain.
2
In addition to driving autoantibody production, TLR7 engagement is likely to contribute to the pathogenesis of inflammatory disease in lupus.
Sometimes inflammation can transition to chronic pain with all the hallmarks of nerve injury -- a cellular event that involves tlr4.
2
When you eat might be almost as important as what you eat.
This is also modifiable by nutrients in the diet, such as by altering the carbohydrate/fat ratio or saturated/unsaturated fat ratio.
1
These reset human escs expressed genes and proteins common only in the more malleable mouse escs, as well as in human preimplantation embryos, but not in conventional human escs.
Demethylation within pluripotency enhancers often occurs at ESC binding sites of pluripotency transcription factors.
2
Participating in exercise training had a moderate effect on sleep quality and reduced the need for sleep enhancing medication in middle aged adults with insomnia, making it a good - and cheap - alternative to drugs.more research is needed to directly compare exercise and sleep medications, however, to consider exercise as an effective first-line of treatment.
More exercise was not always better for psychological wellbeing, with people who exercise every day reporting lower levels of mental health.
2
Participating in exercise training had a moderate effect on sleep quality and reduced the need for sleep enhancing medication in middle aged adults with insomnia, making it a good - and cheap - alternative to drugs.more research is needed to directly compare exercise and sleep medications, however, to consider exercise as an effective first-line of treatment.
For every extra hour of moderate-to-vigorous physical activity, the teens fell asleep 18 minutes earlier, slept 10 minutes longer and had about one percent greater sleep maintenance efficiency that night.
2
Participating in exercise training had a moderate effect on sleep quality and reduced the need for sleep enhancing medication in middle aged adults with insomnia, making it a good - and cheap - alternative to drugs.more research is needed to directly compare exercise and sleep medications, however, to consider exercise as an effective first-line of treatment.
Additional research is required to understand the influence of exercise programs on a variety of cognitive functions.
1
In addition, sex and age jointly moderated the relationship between lifetime TBI and daily smoking, alcohol use and physical injuries.
There was evidence that the association was not significantly altered by stage of liver disease or the presence/absence of high alcohol consumption, high body mass index, type 2 diabetes mellitus, smoking, or hepatitis B and C viruses.
2
, much as in adults, the body maps of infants are organized in a particular way, though there is still much to learn about how the details of these maps are established in the developing brain.
Fetal movement in the third trimester of pregnancy helps to develop areas of the brain that process sensory input.
1
, much as in adults, the body maps of infants are organized in a particular way, though there is still much to learn about how the details of these maps are established in the developing brain.
The same is true for how the brain understands the environments around us.
1
, much as in adults, the body maps of infants are organized in a particular way, though there is still much to learn about how the details of these maps are established in the developing brain.
While infants use memory to learn language and make sense of the world around them, they do not yet have the sophisticated neural architecture needed to form and hold onto more complex forms of memory.
1
Cancer cells might not respond as hoped to drugs that block the glucose uptake, it also suggests blocking lipid uptake might be effective.
Certain types of diabetes drugs can help to decrease the risk of cancer in female patients with type 2 diabetes by up to 32 percent.
2
As additional states continue to debate legalization of marijuana for recreational use, it is critical for the public health community to develop communication strategies that accurately convey the rapidly evolving research evidence regarding recreational marijuana policy.
Marijuana can increase the incidence of mental illness, such as schizophrenia.
2
As additional states continue to debate legalization of marijuana for recreational use, it is critical for the public health community to develop communication strategies that accurately convey the rapidly evolving research evidence regarding recreational marijuana policy.
We found no evidence of a temporal relationship between cannabis use and pain severity or pain interference, and no evidence that cannabis use reduced prescribed opioid use or increased rates of opioid discontinuation.
2
As additional states continue to debate legalization of marijuana for recreational use, it is critical for the public health community to develop communication strategies that accurately convey the rapidly evolving research evidence regarding recreational marijuana policy.
Marijuana is a gateway drug, that it makes one lazy and unproductive, and that marijuana leads to criminal behavior and is bad for the lungs ? well, no, there really is not.
2
Our bodies demonstrate an elevated ability to manage blood glucose in response to eating too many carbohydrates in order to maintain insulin sensitivity.
This is also modifiable by nutrients in the diet, such as by altering the carbohydrate/fat ratio or saturated/unsaturated fat ratio.
2
Our bodies demonstrate an elevated ability to manage blood glucose in response to eating too many carbohydrates in order to maintain insulin sensitivity.
The mechanisms by which reductions in plasma leptin concentrations stimulate food intake are not limited to the brain, as previously thought.
2
Our bodies demonstrate an elevated ability to manage blood glucose in response to eating too many carbohydrates in order to maintain insulin sensitivity.
Fasting glucose did not significantly improve in the health education group.
2
Gal3-dependent-tlr4 activation could contribute to sustained microglia activation, prolonging the inflammatory response in the brain.
Sometimes inflammation can transition to chronic pain with all the hallmarks of nerve injury -- a cellular event that involves tlr4.
2
Further research is necessary to understand whether this is a causal relationship.
Further research is, therefore, necessary to explore the underlying mechanism(s) of these associations.
2
Further research is necessary to understand whether this is a causal relationship.
Additional research is needed in this area.
0
Further research is necessary to understand whether this is a causal relationship.
Additional research is warranted to confirm the results of this study in other samples and populations.
2
Further research is necessary to understand whether this is a causal relationship.
The causal assumptions require further prospective or longitudinal studies on the topic.
1
Tissue damage may result directly from pollutant toxicity because fine and ultrafine particles can gain access to organs, or indirectly through systemic inflammatory processes.
For the latter, our findings may be particularly relevant to efforts to understand cellular damage caused by in vivo production of reactive oxygen species.
2
Tissue damage may result directly from pollutant toxicity because fine and ultrafine particles can gain access to organs, or indirectly through systemic inflammatory processes.
Because suitable biomarkers of long-term exposure do not exist for many common FRs, and levels of FRs in dust are significantly correlated with exposure, relationships between FRs in household dust and PTC were evaluated in addition to available biomarkers.
1
Participants with a lower education level demonstrated a poorer understanding of the medication information.
96 percent of the respondents had heard of prep, but only 25 and 11 percent had received prior training and had prescribed prep, respectively.
2
This study suggests the importance of asking about CAM use in children with ASD, especially those with complex symptoms.
Roughly 1 in 40 american children maintain an autism spectrum disorder (asd) diagnosis, which is a significant increase from the previous estimate of 1 in every 59 children (cdc, 2014).
2
Depressed men experienced worse overall mortality across risk strata (low: relative risk [RR], 1.86; 95% CI, 1.48 to 2.33; P .001;
For example, decreased social support, poor quality social support, and poor marital satisfaction increase the risk of PPD13–15.
2
Depressed men experienced worse overall mortality across risk strata (low: relative risk [RR], 1.86; 95% CI, 1.48 to 2.33; P .001;
More than 200 commonly used prescription drugs, including hormonal birth control medications, blood pressure and heart medications, proton pump inhibitors, antacids and painkillers, have depression or suicide listed as potential side effects.
2
Depressed men experienced worse overall mortality across risk strata (low: relative risk [RR], 1.86; 95% CI, 1.48 to 2.33; P .001;
The choice of antidepressant medication can be guided by a blood sample that measures whether there is an inflammatory condition in the body.
2
Depressed men experienced worse overall mortality across risk strata (low: relative risk [RR], 1.86; 95% CI, 1.48 to 2.33; P .001;
Although similar in direction, there was no statistically significant association between depression and AUD (PR = 1.41; 95% CI = 0.94, 2.11).
2
Depressed men experienced worse overall mortality across risk strata (low: relative risk [RR], 1.86; 95% CI, 1.48 to 2.33; P .001;
Presence of depression and/or anxiety has a statistically and clinically significant negative impact on well being, but not on disability.
2
Depressed men experienced worse overall mortality across risk strata (low: relative risk [RR], 1.86; 95% CI, 1.48 to 2.33; P .001;
In contrast, among controls, those who were depressed rated fewer activities as important, but exhibited few significant differences in the performance of activities.
2
This effect was more apparent in men than in women who had higher cortisol levels in the awakening period.
Environmental cues had a very strong influence on daytime sleep behaviors.
2
Those with a variation in their genetic make-up were less likely to deposit fat under the skin in the lower body.
Total fat mass was not significantly different between the 4 beverage groups.
1
Certain types of diabetes drugs can help to decrease the risk of cancer in female patients with type 2 diabetes by up to 32 percent.
Hormonal contraceptives prevented 21 percent of ovarian cancers in the participants.
2
Certain types of diabetes drugs can help to decrease the risk of cancer in female patients with type 2 diabetes by up to 32 percent.
Patients with diabetes had a significantly worse overall survival compared with patients without diabetes; however, patients who took metformin had only a 10% increase in the risk of death vs patients without diabetes (p = .004).
2
By the time a teen mother reachers her late twenties, she appears to have only slightly more children, is only slightly more likely to be single mother, and has no lower levels of educational attainment than if she had delayed her childbearing to adulthood.
Young adolescents do not perceive situations as less risky than older age groups, but do tend to change their risk perception in the direction of the opinions of similar aged peers.
2
The timing of this suppression appears early in pregnancy, between the first and second trimesters, suggesting that early gestation may be an ecologically important time for events that ordain subsequent term and preterm birth outcomes.
This may indicate an androgen influence on the pathophysiologic mechanism of preeclampsia.
2
The timing of this suppression appears early in pregnancy, between the first and second trimesters, suggesting that early gestation may be an ecologically important time for events that ordain subsequent term and preterm birth outcomes.
Pregnancy is a crucial period during which exposure to stress can negatively affect the health of both mother and baby.
1
The timing of this suppression appears early in pregnancy, between the first and second trimesters, suggesting that early gestation may be an ecologically important time for events that ordain subsequent term and preterm birth outcomes.
Together, these studies confirm OGT as in important placental biomarker of maternal stress and demonstrate the profound impact a single placental gene has on long-term metabolic and neurodevelopmental programming that may be related to an increased risk for neurodevelopmental disorders.
2
The timing of this suppression appears early in pregnancy, between the first and second trimesters, suggesting that early gestation may be an ecologically important time for events that ordain subsequent term and preterm birth outcomes.
Fetal movement in the third trimester of pregnancy helps to develop areas of the brain that process sensory input.
1
The timing of this suppression appears early in pregnancy, between the first and second trimesters, suggesting that early gestation may be an ecologically important time for events that ordain subsequent term and preterm birth outcomes.
Preeclampsia is not in fact a single disease caused solely by genetic factors.
1
Marijuana can increase the incidence of mental illness, such as schizophrenia.
One in 10 regular marijuana users become dependent on the drug.
2
Marijuana can increase the incidence of mental illness, such as schizophrenia.
Prenatal marijuana exposure may impair fetal growth and brain development, less is known about the effects of marijuana on breastfeeding infants.
1
Marijuana can increase the incidence of mental illness, such as schizophrenia.
In addition, Δ 9 -THC reduced total signal power during both active drug conditions compared with placebo, but no relationship was detected between signal power and psychosis-like symptoms.
2
Marijuana can increase the incidence of mental illness, such as schizophrenia.
We found no evidence of a temporal relationship between cannabis use and pain severity or pain interference, and no evidence that cannabis use reduced prescribed opioid use or increased rates of opioid discontinuation.
2
Marijuana can increase the incidence of mental illness, such as schizophrenia.
Marijuana is a gateway drug, that it makes one lazy and unproductive, and that marijuana leads to criminal behavior and is bad for the lungs ? well, no, there really is not.
2
Parental monitoring of adolescent behavior -- especially in setting a bedtime -- strongly determined healthy sleep habits.
For every extra hour of moderate-to-vigorous physical activity, the teens fell asleep 18 minutes earlier, slept 10 minutes longer and had about one percent greater sleep maintenance efficiency that night.
2
Parental monitoring of adolescent behavior -- especially in setting a bedtime -- strongly determined healthy sleep habits.
Environmental cues had a very strong influence on daytime sleep behaviors.
2
Possibly the most challenging issues will be to better understand the magnitude of global soil carbon feedbacks to climate change and to mitigating climate change in a timely fashion.
There are still many gaps in our knowledge of effects of climate change on biodiversity.
1
Even stringent fertility restrictions or a catastrophic mass mortality would not bring about large enough change this century to solve issues of global sustainability.
Making sensible changes in aquaculture and agriculture production would avoid reaching that threshold.
2
Even stringent fertility restrictions or a catastrophic mass mortality would not bring about large enough change this century to solve issues of global sustainability.
Population growth was not directly correlated to emissions growth.
2
Even stringent fertility restrictions or a catastrophic mass mortality would not bring about large enough change this century to solve issues of global sustainability.
The original genetic stock is not significant when studying 200 years into the future.
2
Medical and nonmedical use of prescription opioids has declined recently and remained highly correlated over the past 4 decades.
We found no evidence of a temporal relationship between cannabis use and pain severity or pain interference, and no evidence that cannabis use reduced prescribed opioid use or increased rates of opioid discontinuation.
2
During wakefulness, when chromosome dynamics are low, dna damage consistently accumulates and can reach unsafe levels.
Melatonin treatment increased TRAIL-induced A549 cell death under hypoxic conditions, although hypoxia inhibited TRAIL-mediated cell apoptosis.
2
People suffering from allergies are 50% more likely to also have symptoms of depression- and if a person has seen an allergist- that statistic jumps to 70%.
Presence of depression and/or anxiety has a statistically and clinically significant negative impact on well being, but not on disability.
1
Abstinence from vaginal sex significantly increased from 10% at baseline to 34% at 6 months (p <.01) and abstinence from oral sex increased from 25% to 80% (p <.01).
Significant improvements in overall sexual function, most reproductive hormones and in psychological status were maintained over two years following surgery.
2
The cause of the transformation may be linked to the adoption of a more sedentary lifestyle.
Mobility levels first declined at the onset of food production, but the transition to a more sedentary lifestyle was gradual, extending through later agricultural intensification.
1
Bct may be an option for patients whose tumors measure more than 5 cm, despite a lack of clinical trial data supporting bct in these patients.
With a median follow-up of 36.7 months, the median overall survival from the date of the first randomization was not significantly different between chemotherapy at 16.5 months (95% CI, 14.5-18.5 months) and chemoradiotherapy at 15.2 months (95% CI, 13.9-17.3
1
Societal factors influence the gender differences.
For both racial groups, age, sex, BMI, years overweight, annual income, and education level did not account for a significant portion of the variance in BDI scores.
2
Results of established test methods with animal models and cell lines used up until now can hardly be translated to the processes in the human brain.
Despite improvements on both the dual n-back and visual search tasks with practice, and despite a high level of statistical power, there was no positive transfer to any of the cognitive ability tests.
1
This may indicate an androgen influence on the pathophysiologic mechanism of preeclampsia.
Preeclampsia is not in fact a single disease caused solely by genetic factors.
1
A decrease in blameworthiness actually accounted for the association between diminished belief in free will and support of lighter sentences for crimes.
Decreased blameworthiness actually accounted for the relationship between diminished belief in free will and lighter sentences.
2
The relatively simple genomic architecture of species differences facilitates the evolution of linkage disequilibrium in the presence of gene flow.
This suggests a remarkable genetic uniformity and little phylogeographic structure over a large geographic area of the pre-Neolithic populations.
2
Being bullied increases the risk of sleep disorders called parasomnias, which are related to nightmares, night terrors or sleep-walking.
Bully-victims are perhaps the most vulnerable group of all.
2
Under the current climate, statistical restrictions on species distribution modelling means that important sites for narrow-ranging and threatened species are systematically down-played.
High-value riparian climate-corridors are least protected in flat, lowland areas, suggesting that such corridors should be high priorities for future conservation effort.
2
Under the current climate, statistical restrictions on species distribution modelling means that important sites for narrow-ranging and threatened species are systematically down-played.
There are still many gaps in our knowledge of effects of climate change on biodiversity.
1
Deficits in executive functions increase the risk for experiencing repeated academic difficulties in mathematics, reading and science from first to third grade.
For the entire sample, there were no differences in symptom trajectories between study arms; mean differences in change scores at 12 months were –0.14 (95% confidence interval –0.34 to 0.07) for inattention; –0.13 (–0.31 to 0.05) for hyperactivity/impulsivity; –0.09 (–0.28 to 0.11) for oppositionality; and 3.30 (–1.23 to 7.82) for social skills.
2
These longer bacteria were least affected by rifampicin.
Not all strains of bacteria fight the same way.
2