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[ "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "ATF4 is a general endoplasmic reticulum stress marker.", "Consumption of whole fruits increases the risk of type 2 diabetes.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "MT binding domain drives amyloid structure formation.", "The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death." ]

[ "0-dimensional biomaterials lack inductive properties.", "Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.", "Myelin sheaths are lipid-rich cellular structures.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Mitochondria play a major role in energy production.", "Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.", "The proliferative capacity of neural progenitors differs across species.", "Immune responses in immune cells are geographically segregated.", "Specialized functional cell types can be derived from human pluripotent stem cells.", "Bone marrow cells don't contribute to adult macrophage compartments." ]

[ "Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "5'-nucleotidase metabolizes 6MP.", "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "5'-nucleotidase metabolizes 6MP.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "Antimicrobial agents are less effective due to the pressure of antimicrobial usage.", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.", "The DESMOND program demonstrates no significant impact on biochemical outcomes." ]

[ "1 in 5 million in UK have abnormal PrP positivity.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Sepsis related mortality has risen from 2009 to 2014.", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.", "Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Sepsis related mortality has remained stable between 2009-2014." ]

[ "Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "Pioglitazone use is not associated with an increased risk of prostate cancer.", "Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "MT binding domain drives amyloid structure formation.", "Natriuretic peptides increase susceptibility to diabetes." ]

[ "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Bariatric surgery reduces colorectal cancer.", "Bariatric surgery increases rates of colorectal cancer.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors." ]

[ "Distant CREs are less conserved among species.", "BCL-2 activation antagonizes the apoptotic effects of c-Myc.", "Sympathetic nerve activity is elevated throughout normal pregnancy.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "1 in 5 million in UK have abnormal PrP positivity.", "Increased flux of microbial products suppresses immune responses.", "Lack of FGF21 in mice increases life expectancy.", "Bariatric surgery leads to negative outcomes in mental health.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone." ]

[ "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "53% of perinatal mortality is due to low birth weight.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "The peak incidence of fractures occurs in toddlers.", "Sepsis related mortality has risen from 2009 to 2014.", "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "Incidence of sepsis has fallen substantially from 2009 to 2014." ]

[ "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.", "Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.", "Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.", "Increased flux of microbial products suppresses immune responses.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "Pyridostatin prevents double-strand breaks accumulation." ]

[ "32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.", "The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "Incidence of heart failure increased by 10% in women since 1979.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases." ]

[ "Bacteriophagaes MS2 and Qβ are members of the Leviviridae.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.", "Chemical injury represses transglutaminase 2 activity.", "The density of cytokine receptor bearing cells affects the distance over which cytokines act.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "Misunderstandings between doctors and patients can lead to non-adherence.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias." ]

[ "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "CHOP is a general endoplasmic reticulum stress marker.", "BiP is a general endoplasmic reticulum stress marker.", "ATF4 is a general endoplasmic reticulum stress marker.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "Ethanol stress increases the expression of IBP in bacteria." ]

[ "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.", "F4/80+ macrophages regulate mature osteoblast maintenance.", "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "Ethanol stress reduces the expression of SRL in bacteria.", "Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume." ]

[ "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "CHOP is a general endoplasmic reticulum stress marker.", "BiP is a general endoplasmic reticulum stress marker.", "ATF4 is a general endoplasmic reticulum stress marker.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "Ethanol stress increases the expression of IBP in bacteria.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae." ]

[ "Distant CREs are important for transcriptional regulation.", "Insulin effects appetite via ventral tegmental neurons.", "Depletion of nitric oxide is responsible for vasospasm.", "ART has no effect on the infectiveness of HIV-positive people.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.", "Bariatric surgery increases rates of colorectal cancer.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals." ]

[ "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "A deficiency of folate increases blood levels of homocysteine.", "Insulin decreases risk of severe kidney failure.", "Vitamin D deficiency effects birth weight.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight." ]

[ "Patients with common epithelial cancers are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Increased flux of microbial products provokes immune responses.", "Helminths interfere with immune system control of coinfections by microbial pathogens 16.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.", "Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "The DESMOND program demonstrates no significant impact on biochemical outcomes.", "Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors." ]

[ "5'-nucleotidase metabolizes 6MP.", "Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "The PPR MDA5 has twenty N-terminal CARD domains.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments." ]

[ "The minor G allele of FOXO3 up-regulates IL-10.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "In British Men, haplogroup I decreases risk of cardiovascular disease.", "Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Genetic deletion of JAM-A increases gut permeability.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle." ]

[ "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "TMEM27 is a marker for beta cells.", "In pediatric tissue, most T cells are naive T cell emigrants from the thymus." ]

[ "Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "Physical injury represses transgultaminase activity.", "Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion.", "MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease." ]

[ "53% of perinatal mortality is due to low birth weight.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Birth-weight is negatively associated with breast cancer.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes." ]

[ "Adult tissue-resident macrophages are seeded before birth.", "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "Walking in traffic areas in London did not improve lung function in elderly adults.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "Surfactin producing cells and exopolymer producing cells cooperate to generate \"Van Gogh\" bundles that have sliding abilities on specialized media.", "Pyridostatin induces double-strand breaks accumulation.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology." ]

[ "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Bariatric surgery reduces colorectal cancer.", "Bariatric surgery increases rates of colorectal cancer.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors." ]

[ "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "COPI coatmer is involved in viral replication.", "cSMAC formation represses weak ligand signalling.", "HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.", "Bcp1 is a chaperone for Rpl23.", "PTEN is a regulator for the transcriptional activity of SRF", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.", "Long - range chromatin interactions regulate transcription." ]

[ "7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.", "7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "The proliferative capacity of neural progenitors differs across species.", "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease." ]

[ "Pioglitazone use is not associated with an increased risk of prostate cancer.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "F4/80+ macrophages regulate mature osteoblast maintenance.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Trans-acting factors, such as lncRNAs, influence mRNA translation.", "Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.", "Glycan adaptation is rarely observed in the B-cell repertoire.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK." ]

[ "7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.", "7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Headaches are correlated with cognitive impairment." ]

[ "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.", "53% of perinatal mortality is due to low birth weight.", "In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.", "Rapamycin increases the concentration of triacylglycerols in fruit flies.", "TRAP+ osteoclasts regulate mature osteoblast maintenance." ]

[ "70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Patients with common epithelial cancers are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "Sepsis related mortality has risen from 2009 to 2014.", "One in five surgical randomized controlled trials are discontinued early.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "One in two surgical randomized controlled trials are discontinued early.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals." ]

[ "The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Hypocretin neurones suppress panicprone state in rats.", "V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.", "Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "Cnn1 recruitment varies with cell cycle timing.", "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "N348I mutations cause resistance to nevirapine.", "Eliminating the last sporadic cases of malaria requires considerable funding." ]

[ "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "The mean suicide rate in women is higher after miscarriage than live birth.", "The mean suicide rate in women is lower after miscarriage than live birth.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "53% of perinatal mortality is due to low birth weight.", "Sepsis related mortality has risen from 2009 to 2014.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.", "Input from mental and physical health care professionals is not effective at decreasing homelessness." ]

[ "Cognitive behavioral therapy is an ineffective treatment for insomnia", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Tirasemtiv has no effect on cardiac muscle.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "Dexamethasone increases risk of postoperative bleeding.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone." ]

[ "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "Side effects associated with antidepressants increases risk of stroke.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes." ]

[ "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.", "Distant CREs are important for transcriptional regulation.", "Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "Expression of oncolytic virus antigens as peptides makes relapse more likely.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision." ]

[ "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "53% of perinatal mortality is due to low birth weight.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "The peak incidence of fractures occurs in toddlers.", "Sepsis related mortality has risen from 2009 to 2014.", "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "Incidence of sepsis has fallen substantially from 2009 to 2014." ]

[ "Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "Glial calcium waves influence seizures.", "Chenodeoxycholic acid treatment decreases brown adipose tissue activity.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.", "Exercise reduces cancer mortality rates among Chinese citizens.", "Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.", "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes." ]

[ "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.", "There is no increased risk of hypospadias with clomiphene.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients." ]

[ "YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "LRBA promotes CTLA - 4 recycling.", "Cognitive behavioral therapy is an ineffective treatment for insomnia", "Headaches are correlated with cognitive impairment.", "The peak incidence of fractures occurs in toddlers.", "In British Men, haplogroup I increases risk of cardiovascular disease by 50%.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population." ]

[ "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "There is no increased risk of hypospadias with clomiphene.", "Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients." ]

[ "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Ethanol stress lowers the expression of PSP in bacteria.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "BLM gene encodes RecQ-class DNA helicase.", "Active Ly49Q prevents neutrophil polarization.", "The peak incidence of fractures occurs in toddlers.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Environmental factors can influence the development of breast cancer.", "DUSP4 downregulation deactivates the Ras-ERK pathway", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms." ]

[ "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "Basophils promote disease development in patients with systemic lupus erythematosus (SLE).", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.", "EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.", "In pediatric tissue, most T cells are naive T cell emigrants from the thymus." ]

[ "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Inside the body, falciparum parasites reproduce asexually.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility.", "Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.", "Transcription rates in S. cerevisiae range between 7 and 12 kb/min.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "eRNAs influence is linked to senescence, aging, and carcinogenesis.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells." ]

[ "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "Pioglitazone use is not associated with an increased risk of prostate cancer.", "Side effects associated with antidepressants increases risk of stroke.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Side effects associated with antidepressants lower risk of myocardial infarction." ]

[ "There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "eRNAs influence is linked to senescence, aging, and carcinogenesis.", "Rapamycin increases the concentration of triacylglycerols in fruit flies.", "There is no relation between Erythromycin use and hypertrophic pyloric stenosis.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.", "Adult tissue-resident macrophages are seeded before birth." ]

[ "A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons." ]

[ "Piezo1 channels are sensors for cell migration in epithelial cells.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "β-sheet opening occurs during pleurotolysin pore formation.", "BCL-2 activation antagonizes the apoptotic effects of c-Myc.", "Tonic signaling from the scFv induces constitutive stimulation.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "ART has no effect on the infectiveness of HIV-positive people.", "Tirasemtiv targets fast-twitch muscle." ]

[ "A deficiency of folate increases blood levels of homocysteine.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression." ]

[ "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "miR-142-5P is a known regulator of raised body temperature.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Antidepressants reduce the severity of migraines.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage." ]

[ "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "A deficiency of folate increases blood levels of homocysteine.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "Vitamin D deficiency effects birth weight.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.", "Carriers of HNF4A mutations are at reduced risk for diabetes." ]

[ "Increased flux of microbial products provokes immune responses.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.", "Progerin induces premature aging in stem cells.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation." ]

[ "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "A deficiency of folate increases blood levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "Vitamin D deficiency effects birth weight.", "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression." ]

[ "V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "Lack of FGF21 in mice increases life expectancy.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.", "Beta-band coherence is enhanced for visible stimuli over invisible stimuli.", "Monoclonal antibody targeting of N-cadherin encourages castration resistance.", "Natriuretic peptides protect against diabetes." ]

[ "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "The number of unfertilized oocytes in mated hermaphrodites increases with age.", "Women with a lower birth weight are more likely to develop breast cancer later in life." ]

[ "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.", "Surfactin producing cells and exopolymer producing cells cooperate to generate \"Van Gogh\" bundles that have sliding abilities on specialized media.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).", "Perigenital skin is not the primary site of HIV acquisition.", "Upregulation of PD1 causes the upregulation of Satb1.", "The density of cytokine receptor bearing cells affects the distance over which cytokines act.", "Aggravated inflammation is dependent on NLRP3 inflammasome activation." ]

[ "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "The number of unfertilized oocytes in mated hermaphrodites increases with age.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Women with a lower birth weight are more likely to develop breast cancer later in life." ]

[ "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "Adult tissue-resident macrophages are seeded before birth.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "Bariatric surgery leads to positive outcomes in mental health.", "Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "Deleting Raptor increases G-CSF levels.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events." ]

[ "A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).", "Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.", "A deficiency of folate increases blood levels of homocysteine.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "HNF4A mutations are associated with macrosomia in infancy." ]

[ "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.", "cSMAC formation represses weak ligand signalling.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "ART has no effect on the infectiveness of HIV-positive people.", "Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments." ]

[ "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "The HSV-2 infection is typically asymptomatic.", "Perigenital skin is not the primary site of HIV acquisition.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Hematopoietic Stem Cell purification reaches purity rates above 90%.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Malaria has a high vectorial capacity." ]

[ "Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "5'-nucleotidase metabolizes 6MP.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Ca2+ cycling is a UCP1-dependent thermogenic mechanism.", "In pediatric tissue, most T cells are naive T cell emigrants from the thymus.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min.", "The origin of the CRF01_1b2k protein occurred between 1923 and 1956." ]

[ "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "HNF4A mutations are associated with macrosomia in infancy.", "There is no association between HNF4A mutations and diabetes risks.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period." ]

[ "Localization of PIN1 in the roots of Arabidopsis requires VPS9a", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "Active H. pylori urease has a polymeric structure consisting of five distinct subunits.", "Alteration of origin firing causes changes in termination zones of Okazaki fragments.", "Gastric lavage is an effective treatment for acute paraquat poisoning.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Tonic signaling from the scFv induces constitutive stimulation." ]

[ "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "HNF4A mutations are associated with macrosomia in infancy.", "There is no association between HNF4A mutations and diabetes risks.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period." ]

[ "The risk of cancer rises with level of alcohol consumption.", "Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact.", "Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.", "Women are more susceptible to death due to pneumonia when compared to men.", "Lamins are found within the inner layer of the nuclear membrane of all cells.", "β-sheet opening occurs during pleurotolysin pore formation.", "p16INK4A degradation is linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "CCL19 is predominantly present within dLNs." ]

[ "A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.", "HNF4A mutations are associated with macrosomia in infancy.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "There is no association between HNF4A mutations and diabetes risks." ]

[ "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.", "The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia." ]

[ "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.", "Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.", "In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung." ]

[ "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "Rapamycin increases the concentration of triacylglycerols in fruit flies.", "Immune responses in immune cells are geographically segregated.", "N348I mutations cause resistance to nevirapine.", "Pyridostatin induces double-strand breaks accumulation.", "Antidepressants increase the severity of migraines.", "Nonsteroidal antinflammatory drugs show potential anticancer indications.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Microcin J25 inhibits nucleoside triphosphate (NTP) binding." ]

[ "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "Normal expression of RUNX1 causes tumorsupressing effects.", "TNFAIP3 is a glioblastoma tumor enhancer.", "TNFAIP3 is a glioblastoma tumor suppressor.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells." ]

[ "Prescribed exercise training improves quality of life.", "Expression of oncolytic virus antigens as peptides permits additional protection against relapse.", "Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "Transplanted human glial progenitor cells can mature in their host animal.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "LDL cholesterol has a causal role in the development of cardiovascular disease." ]

[ "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm." ]

[ "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "Elevated cell-free mitochondrial DNA levels are associated with mortality.", "Oxidative DNA damage activates STING signalling.", "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.", "Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.", "Distant CREs are less conserved among species.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease." ]

[ "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.", "Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation." ]

[ "Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.", "KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.", "Self-advocacy training is effective at decreasing homelessness.", "Pyridostatin deregulates G2/M progression.", "Venules have less significant tunica adventitia than arterioles.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "NR5A2 does not play a role in development of endometrial tissues.", "Klf4 is not required for proper myeloid cell differentiation.", "In British Men, haplogroup I increases risk of cardiovascular disease by 50%." ]

[ "ART has no effect on the infectiveness of HIV-positive people.", "ART substantially reduces infectiveness of HIV-positive people.", "Having a main partner worsens HIV outcomes.", "Perigenital skin is not the primary site of HIV acquisition.", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "Having a main partner improves HIV outcomes.", "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo." ]

[ "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "There is no increased risk of hypospadias with clomiphene.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "Lack of FGF21 in mice leads to reduced lifespan.", "The one-child policy has created a hospitable environment for female infants." ]

[ "ART substantially reduces infectiveness of HIV-positive people.", "ART has no effect on the infectiveness of HIV-positive people.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "Perigenital skin is not the primary site of HIV acquisition.", "Having a main partner worsens HIV outcomes.", "Having a main partner improves HIV outcomes.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells." ]

[ "The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "The minor G allele of FOXO3 up-regulates IL-10.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Walking in traffic areas in London improves lung function in elderly adults.", "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "ATM and Rad3 related protein are critical for sensing DNA damage.", "Tonic signaling from the scFv prevents constitutive stimulation.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "NR5A2 is important in reverse cholesterol transport in humans." ]

[ "ATF4 is a general endoplasmic reticulum stress marker.", "BiP is a general endoplasmic reticulum stress marker.", "CHOP is a general endoplasmic reticulum stress marker.", "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.", "Deltex has no known interactions with eIF3f.", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance." ]

[ "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Immune responses in immune cells are geographically segregated.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "Persister cells provide relapse resistance in cancer patients." ]

[ "ATM and Rad3 related protein are critical for sensing DNA damage.", "ATM and Rad3 related protein have no role in sensing DNA damage.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "RAD52 is involved in break-induced DNA replication (BIR).", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues." ]

[ "Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.", "Cnn1 recruitment varies with cell cycle timing.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "Whole brain radiotherapy increases the occurrence of new brain metastases.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Ethanol stress increases the expression of PSP in bacteria.", "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility.", "V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress." ]

[ "ATM and Rad3 related protein have no role in sensing DNA damage.", "ATM and Rad3 related protein are critical for sensing DNA damage.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "RAD52 is involved in break-induced DNA replication (BIR).", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells." ]

[ "Physical activity does not improve cognitive function in individuals with Alzheimers.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "Upregulation of PD1 causes the downmodulation of Satb1.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "HOXB4 facilitates HSC expansion when co-cultured with HSCs.", "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.", "Progerin induces premature aging in stem cells.", "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes." ]

[ "AZT given with ribavirin increases anemia.", "Antidepressants increase the severity of migraines.", "Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.", "Alirocumab treatment reduces apo(a) fractional clearance rate.", "Antidepressants reduce the severity of migraines.", "Side effects associated with antidepressants increases risk of stroke.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "A deficiency of folate increases blood levels of homocysteine.", "The most prevalent adverse events to Semaglutide are gastrointestinal." ]

[ "Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.", "Prescribed exercise training improves quality of life.", "The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "eRNAs influence is linked to senescence, aging, and carcinogenesis.", "Active Ly49Q induces neutrophil polarization.", "MafA phosphorylation decreases its ubiquitination.", "Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.", "Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals." ]

[ "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "ATM and Rad3 related protein have no role in sensing DNA damage.", "ATM and Rad3 related protein are critical for sensing DNA damage.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS." ]

[ "Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.", "Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.", "Walking in traffic areas in London improves lung function in elderly adults.", "siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.", "Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites." ]

[ "Activated Cdk5 regulates DNA damage-induced neuronal death.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "Activation of PPM1D enhances p53 function.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues." ]

[ "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "β1/Ketel is able to bind microtubules.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.", "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.", "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "Sympathetic nerve activity is elevated throughout normal pregnancy.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose." ]

[ "Activation of PPM1D enhances p53 function.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "p16INK4A degradation is encoded by CDKN2A.", "MeCP2 influences the synaptic maturation of neurons.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "Upregulation of PD1 causes the downmodulation of Satb1.", "Upregulation of PD1 causes the upregulation of Satb1." ]

[ "N348I mutations reduce resistance to nevirapine.", "EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.", "COPI coatmer is involved in lipid homeostasis.", "Depletion of nitric oxide is responsible for vasospasm.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.", "Microglia are an innate immune cell type of the peripheral nervous system.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.", "Neutrophils produce IL-1β in response to large particles.", "ART substantially reduces infectiveness of HIV-positive people.", "Ca2+ cycling is a UCP1-independent thermogenic mechanism." ]

[ "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "Activation of PPM1D enhances p53 function.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.", "The PRDM1 gene is a key determinant of primordial germ cells.", "Localization of PIN1 in the roots of Arabidopsis requires VPS9a", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells." ]

[ "HAND2 methylation is a key step in early endometrial carcinogenesis.", "Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.", "Systemic lupus erythematosus is a risk factor for cardiovascular disease.", "Pro-inflammatory cytokines are up regulated during tumor development.", "KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "Insulin effects appetite via ventral tegmental neurons.", "In the UK, drowning affects boys and girls equally.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "Carriers of HNF4A mutations are at reduced risk for diabetes." ]

[ "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "Beta-band coherence is enhanced for visible stimuli over invisible stimuli.", "Beta-band coherence is diminished for visible stimuli over invisible stimuli.", "During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells." ]

[ "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "DUSP4 downregulation deactivates the Ras-ERK pathway", "Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "Exercise reduces cancer mortality rates among Chinese citizens.", "Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "Phase information is useful for predicting donor-recipient matches in organ transplantation.", "Suboptimal nutrition is a leading cause of premature death", "CCL19 is predominantly present within dLNs." ]

[ "Active H. pylori urease has a polymeric structure consisting of five distinct subunits.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Ethanol stress reduces the expression of SRL in bacteria." ]

[ "Having a main partner improves HIV outcomes.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "Cnn1 recruitment varies with cell cycle timing.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "The amount of publicly available DNA data doubles every 10 months.", "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "Intra-cerebroventricular infusion of amyloid-β oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Ribosomopathies have a high degree of cell and tissue specific pathology.", "JMJD6 slows the hydroxylation of C-terminal lysine" ]

[ "Active Ly49Q induces neutrophil polarization.", "Active Ly49Q prevents neutrophil polarization.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "JMJD6 slows the hydroxylation of C-terminal lysine", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Neutrophils produce IL-1β in response to large particles.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Activation of PPM1D enhances p53 function." ]

[ "NAC destabilizes NO to increase the effect of contrast agents on renal functions.", "There is no increased risk of hypospadias with clomiphene.", "Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "British female students are bullied more than British male students.", "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.", "Lamins are found within the inner layer of the nuclear membrane of all cells.", "Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos." ]

[ "Active Ly49Q prevents neutrophil polarization.", "Active Ly49Q induces neutrophil polarization.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "JMJD6 slows the hydroxylation of C-terminal lysine", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Activation of PPM1D enhances p53 function." ]

[ "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "Prescribed exercise training improves quality of life.", "Exercise increases cancer mortality rates among Chinese citizens.", "Inside the body, falciparum parasites reproduce asexually.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.", "Women are more susceptible to death due to pneumonia when compared to men.", "NAC destabilizes NO to increase the effect of contrast agents on renal functions." ]

[ "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "Active caspase-11 protein promotes pyroptosis.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.", "ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "Distant CREs are important for transcriptional regulation.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development." ]

[ "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Pro-inflammatory cytokines are up regulated during tumor development.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Side effects associated with antidepressants increases risk of stroke.", "Distant CREs are important for transcriptional regulation." ]

[ "Active caspase-11 protein promotes pyroptosis.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "Decrease of p62 in prostate tumor stroma results in defective autophagy.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "Mitochondria play a major role in apoptosis." ]

[ "Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Exercise reduces cancer mortality rates among Chinese citizens.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks." ]

[ "Acute ablation of KRAS causes severe growth impairment.", "Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.", "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "aPKCz causes tumour suppression by affecting glutamine metabolism.", "Taking 400mg of α-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Taking 400mg of α-tocopheryl acetate does not prevent prostate cancer.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs." ]

[ "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.", "Tonic signaling from the scFv is amplified by MyD88/CD40.", "Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "The proliferative capacity of neural progenitors differs across species.", "The minor G allele of FOXO3 up-regulates IL-10.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "Exercise reduces cancer mortality rates among Chinese citizens." ]

[ "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "MeCP2 influences the synaptic maturation of neurons.", "Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "Alteration of origin firing causes changes in termination zones of Okazaki fragments.", "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron." ]

[ "Bariatric surgery reduces postmenopausal breast cancer.", "Patients with panic anxiety show decreased CSF levels of hypocretin.", "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Normal granulomas form in the presence of TNF in Zebrafish.", "Microglia are an innate immune cell type of the central nervous system.", "Taking 400mg of α-tocopheryl acetate does not prevent prostate cancer.", "Retinoic acid receptor-related orphan receptor gamma (RORγ) is a therapeutic target for castration-resistant prostate cancer (CRPC)", "Venules have less significant tunica adventitia than arterioles.", "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR." ]

[ "Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)", "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.", "Tirasemtiv targets cardiac muscle." ]

[ "HNF4A mutations are associated with macrosomia in infancy.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "Input from mental and physical health care professionals is not effective at decreasing homelessness.", "Chenodeoxycholic acid treatment increases brown adipose tissue activity.", "JMJD6 slows the hydroxylation of C-terminal lysine", "Progerin induces premature aging in stem cells.", "Oxidative DNA damage inhibits STING signalling.", "De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.", "Sepsis related mortality has remained stable between 2009-2014.", "NR5A2 does not play a role in development of endometrial tissues." ]

[ "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Bone marrow cells don't contribute to adult macrophage compartments.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling." ]

[ "Gastric lavage is an effective treatment for acute paraquat poisoning.", "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.", "Acute ablation of KRAS causes severe growth impairment.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.", "The minor G allele of FOXO3 up-regulates IL-10.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos." ]

[ "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Bone marrow cells don't contribute to adult macrophage compartments.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling." ]

[ "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "Microcin J25 encourages nucleoside triphosphate (NTP) binding.", "Glycan adaptation is rarely observed in the B-cell repertoire.", "Klf4 is not required for proper myeloid cell differentiation.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells." ]

[ "Adult tissue-resident macrophages possess a self-renewing capacity.", "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Bone marrow cells don't contribute to adult macrophage compartments.", "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "Mitochondria play a major role in energy production.", "0-dimensional biomaterials lack inductive properties.", "The proliferative capacity of progenitors is regulated cell-autonomously." ]

[ "The innate immune response struggles to remove small numbers of parasites.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "Beta-band coherence is diminished for visible stimuli over invisible stimuli.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "Charcoal shows no benefit for acute paraquat poisoning." ]

[ "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages are seeded before birth.", "Bone marrow cells don't contribute to adult macrophage compartments.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Microglia are an innate immune cell type of the central nervous system." ]

[ "Participants who quit smoking reduce lung cancer risk by approximately 50%.", "CCL19 is a ligand for CCR7.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.", "Lamins are associated with nuclear membrane structure maintenance.", "Expression of oncolytic virus antigens as peptides makes relapse more likely.", "The number of unfertilized oocytes in mated hermaphrodites increases with age." ]

[ "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages are seeded before birth.", "Bone marrow cells don't contribute to adult macrophage compartments.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Microglia are an innate immune cell type of the central nervous system." ]

[ "cSMAC formation represses weak ligand signalling.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.", "Cnn1 recruitment varies with cell cycle timing.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "Cost effectiveness evaluations based on cRCT data lack external validity.", "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "Localization of PIN1 in the roots of Arabidopsis requires VPS9a" ]

[ "Aged patients are less susceptible to ischaemia/reperfusion injury.", "Aged patients are more susceptible to ischaemia/reperfusion injury.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months." ]

[ "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.", "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "LRBA promotes CTLA - 4 recycling.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.", "PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "53% of perinatal mortality is due to low birth weight." ]

[ "Aged patients are more susceptible to ischaemia/reperfusion injury.", "Aged patients are less susceptible to ischaemia/reperfusion injury.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months." ]

[ "Adult tissue-resident macrophages are seeded before birth.", "Sn is present on mature DCs during inflammation in vivo.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Amitriptyline is an effective treatment for chronic tension-type headaches.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "The proliferative capacity of neural progenitors differs across species.", "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium." ]

[ "Aggravated inflammation is dependent on NLRP3 inflammasome activation.", "PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.", "PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.", "The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.", "The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring." ]

[ "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "The one-child policy has created a hospitable environment for female infants.", "The DESMOND program caused substantial weight loss in most participants.", "ATM and Rad3 related protein are critical for sensing DNA damage.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Perigenital skin is not the primary site of HIV acquisition.", "Rapamycin delays aging in fruit flies.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation." ]

[ "Albendazole is used to treat soil-transmitted helminths.", "Helminths interfere with immune system control of coinfections by microbial pathogens 16.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Antimicrobial agents are less effective due to the pressure of antimicrobial usage.", "Anthrax spores are very difficult to dispose once they are dispersed.", "The DdrB protein from Deinococcus radiodurans functions as a pentamer.", "Anthrax spores remain deadly until affected areas are decontaminated.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "Urbanization is an important risk factor related to the transmission of dengue fever." ]

[ "Upregulation of PD1 causes the upregulation of Satb1.", "Beta-band coherence is diminished for visible stimuli over invisible stimuli.", "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "Bariatric surgery reduces colorectal cancer.", "Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "DMS3 protein enables Pol V transcription in vivo.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "p16INK4A degradation is encoded by CDKN2A." ]

[ "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.", "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.", "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "Malaria has a high vectorial capacity.", "70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK." ]

[ "Prescribed exercise training improves quality of life.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "Sympathetic nerve activity is elevated throughout normal pregnancy.", "One in five surgical randomized controlled trials are discontinued early.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "The risk of female prisoners harming themselves is ten times that of male prisoners.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "Bariatric surgery reduces postmenopausal breast cancer." ]

[ "Alirocumab treatment reduces apo(a) fractional clearance rate.", "AZT given with ribavirin increases anemia.", "Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.", "Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility." ]

[ "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "Insulin decreases risk of severe kidney failure.", "PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.", "Patients with common epithelial cancers are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas." ]

[ "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "Sudden death can occur in patients with complex ventricular arrhythmias.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery." ]

[ "PCSK9 inhibitors decrease plasma Lp(a) levels.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Klf2 is important for proper myeloid cell function.", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "miR-142-5P is a temperature-sensitive microRNA (miRNA).", "A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.", "Oxidative DNA damage activates STING signalling.", "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis." ]

[ "Alteration of origin firing causes changes in termination zones of Okazaki fragments.", "Most termination events in Okazaki fragments are dictated by initiation patterns.", "Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "Immune complex triggered cell death leads to extracellular release of nuclear DNA.", "Cellular clocks are associated with mitosis timing in NIH 3T3 cells.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "Recognition of start codons depends on the translation initiation factor IF3.", "Pyridostatin encourages proliferation of homologous recombination - defective cells." ]

[ "BLM gene encodes RecQ-class DNA helicase.", "Antidepressants increase the severity of migraines.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.", "RUNX is not expressed in skin tissue.", "Egr2 regulates the homeostasis of B and T cells.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.", "A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.", "Treatment with a protein named FN restores regenerative abilities of aged muscles." ]

[ "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "Insulin decreases risk of severe kidney failure.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events." ]

[ "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma." ]

[ "Amitriptyline is an effective treatment for chronic tension-type headaches.", "Antidepressants reduce the severity of migraines.", "Antidepressants increase the severity of migraines.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Side effects associated with antidepressants increases risk of stroke.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "Cognitive behavioral therapy is an ineffective treatment for insomnia", "Pioglitazone use is not associated with an increased risk of prostate cancer.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion." ]

[ "Taking 400mg of α-tocopheryl acetate does not prevent prostate cancer.", "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.", "Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Side effects associated with antidepressants increases risk of stroke.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.", "A deficiency of folate increases blood levels of homocysteine.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Anthrax spores remain deadly until affected areas are decontaminated." ]

[ "An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.", "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "Chenodeoxycholic acid treatment decreases brown adipose tissue activity.", "Chenodeoxycholic acid treatment increases brown adipose tissue activity.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "Ethanol stress reduces the expression of SRL in bacteria.", "Ethanol stress increases the expression of SRL in bacteria.", "aPKCz causes tumour suppression by affecting glutamine metabolism." ]

[ "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.", "The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "qSOFA scores are associated with length of stay in emergency department patients.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments." ]

[ "Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "Mouse models can be generated using \"artificial spermatids.\"", "Specialized functional cell types can be derived from human pluripotent stem cells.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Transplanted human glial progenitor cells can mature in their host animal.", "In pediatric tissue, most T cells are naive T cell emigrants from the thymus.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells." ]

[ "The innate immune response struggles to remove small numbers of parasites.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Rapamycin delays aging in fruit flies.", "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.", "British male students are bullied more than British female students.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "N348I mutations cause resistance to nevirapine.", "JMJD6 slows the hydroxylation of C-terminal lysine" ]

[ "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "NAC destabilizes NO to increase the effect of contrast agents on renal functions.", "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "NAC inhibits the generation of angiotensin-converting enzyme.", "Insulin decreases risk of severe kidney failure.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "A deficiency of folate increases blood levels of homocysteine.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "Lipopolysaccharides have an inflammation independent effect on kidney barrier function." ]

[ "Cellular clocks are associated with mitosis timing in NIH 3T3 cells.", "Aged patients are more susceptible to ischaemia/reperfusion injury.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.", "Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "The innate immune response struggles to remove small numbers of parasites.", "V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.", "Normal expression of RUNX1 causes tumorsupressing effects." ]

[ "Anthrax spores are very difficult to dispose once they are dispersed.", "Anthrax spores remain deadly until affected areas are decontaminated.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "Inside the body, falciparum parasites reproduce asexually.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "Charcoal is an effective treatment for acute paraquat poisoning.", "Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans." ]

[ "RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.", "Pyridostatin induces checkpoint activation.", "Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "The amount of publicly available DNA data doubles every 10 months.", "Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "Ethanol stress reduces the expression of SRL in bacteria." ]

[ "Anthrax spores remain deadly until affected areas are decontaminated.", "Anthrax spores are very difficult to dispose once they are dispersed.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Charcoal is an effective treatment for acute paraquat poisoning.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "The innate immune response struggles to remove small numbers of parasites.", "Charcoal shows no benefit for acute paraquat poisoning." ]

[ "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "Lack of FGF21 in mice leads to reduced lifespan.", "A deficiency of folate increases blood levels of homocysteine.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "The PDPN gene deactivates the C-type lectin receptor (CLEC-2).", "Cognitive behavioral therapy is an ineffective treatment for insomnia", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs." ]

[ "Antidepressants increase the severity of migraines.", "Antidepressants reduce the severity of migraines.", "Side effects associated with antidepressants increases risk of stroke.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Headaches are correlated with cognitive impairment.", "Amitriptyline is an effective treatment for chronic tension-type headaches.", "Patients with panic anxiety show decreased CSF levels of hypocretin.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events." ]

[ "Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.", "Microcin J25 inhibits nucleoside triphosphate (NTP) binding.", "Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "Aged patients are less susceptible to ischaemia/reperfusion injury.", "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "cSMAC formation represses weak ligand signalling." ]

[ "Antidepressants reduce the severity of migraines.", "Antidepressants increase the severity of migraines.", "Side effects associated with antidepressants increases risk of stroke.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Amitriptyline is an effective treatment for chronic tension-type headaches.", "Headaches are correlated with cognitive impairment.", "Patients with panic anxiety show decreased CSF levels of hypocretin.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events." ]

[ "Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.", "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "Basophils promote disease development in patients with systemic lupus erythematosus (SLE).", "PCSK9 inhibitors decrease plasma Lp(a) levels.", "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "Sn is present on mature DCs during inflammation in vivo.", "HOXB4 facilitates HSC expansion when co-cultured with HSCs." ]

[ "Antimicrobial agents are less effective due to the pressure of antimicrobial usage.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "Increased flux of microbial products provokes immune responses.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Increased flux of microbial products suppresses immune responses.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Side effects associated with antidepressants increases risk of stroke.", "Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)" ]

[ "32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.", "LRBA prevents CTLA - 4 recycling.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "Environmental factors can influence the development of breast cancer.", "Insulin decreases risk of severe kidney failure.", "Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS)." ]

[ "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "Antimicrobial agents are less effective due to the pressure of antimicrobial usage.", "Increased flux of microbial products provokes immune responses.", "Increased flux of microbial products suppresses immune responses.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Side effects associated with antidepressants increases risk of stroke.", "Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)" ]

[ "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "BCL-2 activation antagonizes the apoptotic effects of c-Myc." ]

[ "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "Side effects associated with antidepressants increases risk of stroke.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.", "Antidepressants reduce the severity of migraines.", "In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes." ]

[ "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.", "Bacteriophagaes MS2 and Qβ are members of the Leviviridae.", "Systemic lupus erythematosus is a risk factor for cardiovascular disease.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.", "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "Ethanol stress increases the expression of SRL in bacteria.", "Expression of oncolytic virus antigens as peptides permits additional protection against relapse.", "Glycan adaptation is rarely observed in the B-cell repertoire.", "Long - range chromatin interactions regulate transcription." ]

[ "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "In pediatric tissue, most T cells are naive T cell emigrants from the thymus.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)" ]

[ "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "Distant CREs are less conserved among species.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.", "The risk of cancer rises with level of alcohol consumption.", "The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA." ]

[ "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "Misunderstandings between doctors and patients can lead to non-adherence.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Cost effectiveness evaluations based on cRCT data lack external validity.", "Integrated care is ineffective at tackling multiple comorbidities.", "Integrated care is successful at tackling multiple comorbidities.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events" ]

[ "The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Bone marrow cells don't contribute to adult macrophage compartments.", "Having a main partner improves HIV outcomes.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Pyridostatin prevents double-strand breaks accumulation.", "PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "There is no relation between Erythromycin use and hypertrophic pyloric stenosis." ]

[ "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "Headaches are correlated with cognitive impairment.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime." ]

[ "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "The risk of female prisoners harming themselves is ten times that of male prisoners.", "DRD1 proteins enable Pol V transcription in vivo.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Hematopoietic Stem Cell purification reaches purity rates above 90%.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes." ]

[ "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Pro-inflammatory cytokines are up regulated during tumor development.", "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines." ]

[ "JMJD6 slows the hydroxylation of C-terminal lysine", "Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.", "One in two surgical randomized controlled trials are discontinued early.", "Cognitive behavioral therapy is an ineffective treatment for insomnia", "The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.", "Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.", "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells." ]

[ "Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "Transplanted human glial progenitor cells can mature in their host animal.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)" ]

[ "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "Pyridostatin deregulates G2/M progression.", "Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.", "Bariatric surgery reduces postmenopausal breast cancer.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Deleting Raptor increases G-CSF levels.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus." ]

[ "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Insulin decreases risk of severe kidney failure.", "Insulin effects appetite via ventral tegmental neurons.", "Medications to treat obesity have unwanted side effects.", "Medications to treat obesity do not have side effects.", "A deficiency of folate increases blood levels of homocysteine.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "Ethanol stress increases the expression of IBP in bacteria.", "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years." ]

[ "RTEL1 interacts with TRF2 through a C4C4 motif", "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "MICAL redox enzymes regulate actin dynamics.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Bone marrow cells don't contribute to adult macrophage compartments.", "The recruitment of Wdr5 to its target loci depends on Kat8.", "Trans-acting factors, such as lncRNAs, influence mRNA translation." ]

[ "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Egr2 regulates the homeostasis of B and T cells.", "Egr3 regulates the homeostasis of B and T cells.", "Neutrophils produce IL-1β in response to large particles.", "During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.", "TMEM27 is a marker for beta cells.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals." ]

[ "Vitamin D deficiency effects birth weight.", "The minor G allele of FOXO3 up-regulates IL-10.", "Cost effectiveness evaluations based on cRCT data lack external validity.", "Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.", "NAC inhibits the generation of angiotensin-converting enzyme.", "CCL19 is predominantly present within dLNs.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "There is a positive correlation between hip fractures and statin use.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology." ]

[ "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.", "Egr3 regulates the homeostasis of B and T cells.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage." ]

[ "Input from mental and physical health care professionals is not effective at decreasing homelessness.", "Aged patients are less susceptible to ischaemia/reperfusion injury.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "Anthrax spores remain deadly until affected areas are decontaminated.", "Cell autonomous sex determination in somatic cells occurs in Galliformes.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "Distant CREs are important for transcriptional regulation.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).", "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells." ]

[ "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.", "Egr3 regulates the homeostasis of B and T cells.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "MEK inhibitors are effective treatments in RAS-driven mouse models of cancer." ]

[ "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "The recruitment of Wdr5 to its target loci depends on Kat8.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Exposure to fine particulate air pollution is unrelated to anxiety prevalence.", "BCL-2 promotes the apoptotic effects of c-Myc.", "Aggravated inflammation is dependent on NLRP3 inflammasome activation.", "Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.", "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases." ]

[ "BCL-2 activation antagonizes the apoptotic effects of c-Myc.", "BCL-2 promotes the apoptotic effects of c-Myc.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.", "The PDPN gene deactivates the C-type lectin receptor (CLEC-2).", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Activation of PPM1D enhances p53 function.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke." ]

[ "CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.", "Expression of oncolytic virus antigens as peptides permits additional protection against relapse.", "The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.", "Distant CREs are less conserved among species." ]

[ "BCL-2 promotes the apoptotic effects of c-Myc.", "BCL-2 activation antagonizes the apoptotic effects of c-Myc.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.", "The PDPN gene deactivates the C-type lectin receptor (CLEC-2).", "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "5'-nucleotidase metabolizes 6MP.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke." ]

[ "There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.", "Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.", "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.", "Improvements in OER catalysts show stable activity over several hundred hours.", "One in two surgical randomized controlled trials are discontinued early.", "Misunderstandings between doctors and patients can lead to non-adherence.", "Insulin effects appetite via ventral tegmental neurons.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "Dexamethasone increases risk of postoperative bleeding." ]

[ "BLM gene encodes RecQ-class DNA helicase.", "The PPR MDA5 has twenty N-terminal CARD domains.", "RAD52 is involved in break-induced DNA replication (BIR).", "The PRR MDA5 has a C-terminal domain.", "ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.", "Bcp1 is a chaperone for Rpl23.", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "CCL19 is a ligand for CCR7." ]

[ "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "The mean suicide rate in women is lower after miscarriage than live birth.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Monoclonal antibody targeting of N-cadherin encourages castration resistance.", "Treatment with a protein named FN restores regenerative abilities of aged muscles.", "Dexamethasone increases risk of postoperative bleeding.", "LRBA promotes CTLA - 4 recycling.", "Egr2 regulates the homeostasis of B and T cells.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight." ]

[ "BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "Birth-weight is negatively associated with breast cancer.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "Environmental factors can influence the development of breast cancer.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "HNF4A mutations are associated with macrosomia in infancy.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma." ]

[ "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).", "TRAP+ osteoclasts regulate mature osteoblast maintenance.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "Tonic signaling from the scFv induces constitutive stimulation.", "Microglia are an innate immune cell type of the central nervous system.", "PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments." ]

[ "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "Women are more susceptible to death due to pneumonia when compared to men.", "Men are more susceptible to death due to pneumonia when compared to women.", "Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.", "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Oat tolerant coeliac patients may have oat specific inflammatory cells in their small bowel mucosa.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "Urbanization is an important risk factor related to the transmission of dengue fever." ]

[ "HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).", "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Cost effectiveness evaluations based on cRCT data lack external validity.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "LRBA prevents CTLA - 4 recycling.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response." ]

[ "Bacteriophagaes MS2 and Qβ are members of the Leviviridae.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Helminths interfere with immune system control of coinfections by microbial pathogens 16.", "Microglia are an innate immune cell type of the peripheral nervous system.", "Microglia are an innate immune cell type of the central nervous system.", "Basophils promote disease development in patients with systemic lupus erythematosus (SLE)." ]

[ "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.", "Immune responses in immune cells are geographically segregated.", "Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Eliminating the last sporadic cases of malaria requires considerable funding.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue." ]

[ "Bariatric surgery reduces colorectal cancer.", "Bariatric surgery increases rates of colorectal cancer.", "Bariatric surgery increases rates of postmenopausal breast cancer.", "Bariatric surgery reduces postmenopausal breast cancer.", "Bariatric surgery leads to negative outcomes in mental health.", "Bariatric surgery leads to positive outcomes in mental health.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery." ]

[ "The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "Ca2+ cycling is a UCP1-dependent thermogenic mechanism.", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "N348I mutations cause resistance to nevirapine.", "One in two surgical randomized controlled trials are discontinued early.", "Long - range chromatin interactions regulate transcription.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "DMS3 protein enables Pol V transcription in vivo." ]

[ "Bariatric surgery increases rates of postmenopausal breast cancer.", "Bariatric surgery reduces postmenopausal breast cancer.", "Bariatric surgery reduces colorectal cancer.", "Bariatric surgery increases rates of colorectal cancer.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Bariatric surgery leads to negative outcomes in mental health.", "Bariatric surgery leads to positive outcomes in mental health.", "Birth-weight is negatively associated with breast cancer.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma." ]

[ "Anthrax spores are very difficult to dispose once they are dispersed.", "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.", "Ethanol stress increases the expression of PSP in bacteria.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.", "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings." ]

[ "Bariatric surgery leads to negative outcomes in mental health.", "Bariatric surgery leads to positive outcomes in mental health.", "Bariatric surgery reduces colorectal cancer.", "Bariatric surgery increases rates of colorectal cancer.", "Bariatric surgery reduces postmenopausal breast cancer.", "Bariatric surgery increases rates of postmenopausal breast cancer.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology." ]

[ "Increased LDL receptors plays a role in the reduction of plasma Lp(a).", "The peak incidence of fractures occurs in toddlers.", "Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Monoclonal antibody targeting of N-cadherin encourages castration resistance.", "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "MafA phosphorylation decreases its ubiquitination.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Hematopoietic Stem Cell purification reaches purity rates above 90%.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA." ]

[ "Bariatric surgery leads to positive outcomes in mental health.", "Bariatric surgery leads to negative outcomes in mental health.", "Bariatric surgery reduces colorectal cancer.", "Bariatric surgery increases rates of colorectal cancer.", "Bariatric surgery reduces postmenopausal breast cancer.", "Bariatric surgery increases rates of postmenopausal breast cancer.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder." ]