Datasets:

---

spacemanidol

/

scifacts-KALE

like 0

[ "Natriuretic peptides increase susceptibility to diabetes.", "Prescribed exercise training improves quality of life.", "Phase information is useful for predicting donor-recipient matches in organ transplantation.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Alirocumab treatment reduces apo(a) fractional clearance rate.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.", "PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients." ]

[ "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "Klf4 is important for proper myeloid cell differentiation.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Klf4 is not required for proper myeloid cell differentiation.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Klf2 is important for proper myeloid cell function.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs." ]

[ "Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)", "PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.", "Normal expression of RUNX1 causes tumorsupressing effects.", "Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.", "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE)." ]

[ "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Klf4 is important for proper myeloid cell differentiation.", "Klf4 is not required for proper myeloid cell differentiation.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Klf2 is important for proper myeloid cell function.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs." ]

[ "Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.", "Piezo1 channels are sensors for cell migration in epithelial cells.", "In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.", "Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population." ]

[ "Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.", "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "The number of unfertilized oocytes in mated hermaphrodites increases with age.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "53% of perinatal mortality is due to low birth weight." ]

[ "Misunderstandings between doctors and patients can lead to non-adherence.", "Vitamin D deficiency effects birth weight.", "Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.", "Increased flux of microbial products suppresses immune responses.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "Cnn1 recruitment varies with cell cycle timing.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro." ]

[ "Distant CREs are important for transcriptional regulation.", "Distant CREs are less conserved among species.", "Long - range chromatin interactions regulate transcription.", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "eRNAs influence is linked to senescence, aging, and carcinogenesis.", "Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells." ]

[ "DUSP4 downregulation deactivates the Ras-ERK pathway", "Sepsis related mortality has risen from 2009 to 2014.", "TRAP+ osteoclasts regulate mature osteoblast maintenance.", "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "Pro-inflammatory cytokines are up repressed during tumor development.", "AZT given with ribavirin increases anemia.", "Anthrax spores are very difficult to dispose once they are dispersed.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding." ]

[ "Distant CREs are less conserved among species.", "Distant CREs are important for transcriptional regulation.", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.", "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "r-protein chaperones are found in complexes with their r-protein binding partners.", "Long - range chromatin interactions regulate transcription.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "Low nucleosome occupancy correlates with high methylation levels across species." ]

[ "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "qSOFA scores are associated with length of stay in emergency department patients.", "Having a main partner improves HIV outcomes.", "Lipopolysaccharides have an inflammation independent effect on kidney barrier function.", "Active caspase-11 participate in regulating phagosome-lysosome fusion." ]

[ "Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Lamins are found within the inner layer of the nuclear membrane of all cells.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "Lamins are associated with nuclear membrane structure maintenance.", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "Myelin sheaths are lipid-rich cellular structures.", "MICAL redox enzymes regulate actin dynamics in many cell types." ]

[ "BiP is a general endoplasmic reticulum stress marker.", "p16INK4A degradation is linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "Sepsis related mortality has risen from 2009 to 2014.", "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "Hematopoietic Stem Cell purification reaches purity rates above 90%.", "Natriuretic peptides increase susceptibility to diabetes.", "Lamins are found within the inner layer of the nuclear membrane of all cells.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells." ]

[ "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "Microglia are an innate immune cell type of the central nervous system.", "The PPR MDA5 has twenty N-terminal CARD domains.", "The PRR MDA5 has a C-terminal domain.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Microglia are an innate immune cell type of the peripheral nervous system.", "TMEM27 is a marker for beta cells.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "TNFAIP3 is a glioblastoma tumor suppressor.", "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD." ]

[ "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.", "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.", "Charcoal shows no benefit for acute paraquat poisoning.", "Aggravated inflammation is dependent on NLRP3 inflammasome activation.", "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA." ]

[ "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "Recognition of start codons depends on the translation initiation factor IF3.", "The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.", "Pyridostatin prevents double-strand breaks accumulation.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "Stacking is more stable when a purine is present in the +5 position (C1698).", "Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139." ]

[ "Lamins are associated with nuclear membrane structure maintenance.", "The HSV-2 infection is typically asymptomatic.", "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.", "Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.", "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Monoclonal antibody targeting of N-cadherin inhibits growth." ]

[ "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "Pyridostatin prevents double-strand breaks accumulation.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "Stacking is more stable when a purine is present in the +5 position (C1698).", "Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.", "Recognition of start codons depends on the translation initiation factor IF3." ]

[ "Retinoic acid receptor-related orphan receptor gamma (RORγ) is a therapeutic target for castration-resistant prostate cancer (CRPC)", "Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "The innate immune response struggles to remove small numbers of parasites.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Medications to treat obesity are highly effective.", "Progerin induces premature aging in stem cells.", "Sepsis related mortality has risen from 2009 to 2014.", "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled." ]

[ "During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.", "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Egr3 regulates the homeostasis of B and T cells.", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.", "Oxidative DNA damage activates STING signalling.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation." ]

[ "Active Ly49Q prevents neutrophil polarization.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.", "One in five surgical randomized controlled trials are discontinued early.", "The proliferative capacity of neural progenitors differs across species.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.", "MICAL redox enzymes regulate actin dynamics.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels." ]

[ "EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells." ]

[ "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Microglia are an innate immune cell type of the central nervous system.", "Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.", "Alirocumab treatment reduces apo(a) fractional clearance rate.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.", "TNFAIP3 is a glioblastoma tumor enhancer.", "Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance." ]

[ "EGR2 is important to myelination of the peripheral nervous system.", "Egr2 regulates the homeostasis of B and T cells.", "Egr3 regulates the homeostasis of B and T cells.", "MeCP2 influences the synaptic maturation of neurons.", "NR5A2 does not play a role in development of endometrial tissues.", "Tirasemtiv targets cardiac muscle.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Myelin sheaths play a role in action potential propagation.", "NR5A2 is important in reverse cholesterol transport in humans.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance." ]

[ "Bariatric surgery increases rates of postmenopausal breast cancer.", "Incidence of heart failure increased by 10% in women since 1979.", "Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.", "Birth-weight is negatively associated with breast cancer.", "LRBA promotes CTLA - 4 recycling.", "MICAL redox enzymes regulate actin dynamics in many cell types.", "Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells." ]

[ "ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.", "The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions." ]

[ "DMS3 protein enables Pol V transcription in vivo.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "Obesity raises life quality.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "The amount of publicly available DNA data doubles every 10 months.", "In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.", "Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.", "Intra-cerebroventricular infusion of amyloid-β oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi." ]

[ "ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.", "Localization of PIN1 in the roots of Arabidopsis requires VPS9a", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "N348I mutations cause resistance to nevirapine.", "HNF4A mutations are associated with macrosomia in infancy.", "N348I mutations reduce resistance to nevirapine.", "A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.", "Pseudogene PTENP1 encodes a transcript that regulates PTEN expression." ]

[ "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "The minor G allele of FOXO3 up-regulates IL-10.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.", "TNFAIP3 is a glioblastoma tumor enhancer.", "MafA phosphorylation decreases its ubiquitination.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos." ]

[ "Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.", "Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.", "One in five surgical randomized controlled trials are discontinued early.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin." ]

[ "Glial calcium waves influence seizures.", "Pyridostatin prevents double-strand breaks accumulation.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "Medications to treat obesity do not have side effects.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Charcoal is an effective treatment for acute paraquat poisoning." ]

[ "Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.", "Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice." ]

[ "Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "Self-advocacy training is effective at decreasing homelessness.", "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.", "Antidepressants reduce the severity of migraines.", "There is no association between HNF4A mutations and diabetes risks.", "The PRR MDA5 has a C-terminal domain.", "The mean suicide rate in women is lower after miscarriage than live birth.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability." ]

[ "Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.", "Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)", "Specialized functional cell types can be derived from human pluripotent stem cells.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "MICAL redox enzymes regulate actin dynamics in many cell types.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.", "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "Myelin sheaths are lipid-rich cellular structures." ]

[ "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Input from mental and physical health care professionals is not effective at decreasing homelessness.", "Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).", "Taking 400mg of α-tocopheryl acetate does not prevent prostate cancer.", "Increased LDL receptors plays a role in the reduction of plasma Lp(a).", "miR-142-5P is a known regulator of raised body temperature.", "LRBA prevents CTLA - 4 recycling.", "Upregulation of PD1 causes the downmodulation of Satb1.", "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis." ]

[ "Egr2 regulates the homeostasis of B and T cells.", "Egr3 regulates the homeostasis of B and T cells.", "EGR2 is important to myelination of the peripheral nervous system.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells." ]

[ "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "The proliferative capacity of neural progenitors differs across species.", "Oxidative DNA damage activates STING signalling.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.", "Distant CREs are less conserved among species.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "RUNX1 is downregulated or mutated in TLX1 T-ALL.", "Bariatric surgery increases rates of colorectal cancer." ]

[ "Egr3 regulates the homeostasis of B and T cells.", "Egr2 regulates the homeostasis of B and T cells.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "EGR2 is important to myelination of the peripheral nervous system.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "IL-10 production by monocytes inhibits CD4 + T cell response." ]

[ "The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.", "qSOFA scores are associated with length of stay in emergency department patients.", "Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain", "Oxidative DNA damage activates STING signalling.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.", "Migraine with aura is associated with ischemic stroke.", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells." ]

[ "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "Malaria has a high vectorial capacity.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission." ]

[ "Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "Pyridostatin reduces proliferation of homologous recombination - defective cells.", "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "The origin of the CRF01_1b2k protein occurred between 1923 and 1956.", "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.", "Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors." ]

[ "Elevated cell-free mitochondrial DNA levels are associated with mortality.", "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "53% of perinatal mortality is due to low birth weight.", "Suboptimal nutrition is a leading cause of premature death", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "A deficiency of folate increases blood levels of homocysteine." ]

[ "Active Ly49Q induces neutrophil polarization.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Acute ablation of KRAS causes severe growth impairment.", "Transcription rates in S. cerevisiae range between 7 and 12 kb/min.", "Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.", "The origin of the CRF01_1b2k protein occurred between 1923 and 1956.", "Lamins have no effect on nuclear membrane structure maintenance.", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus." ]

[ "Eliminating the last sporadic cases of malaria requires considerable funding.", "Malaria has a high vectorial capacity.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships." ]

[ "In pediatric tissue, most T cells are naive T cell emigrants from the thymus.", "COPI coatmer is involved in lipid homeostasis.", "Bariatric surgery reduces colorectal cancer.", "The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene.", "Monoclonal antibody targeting of N-cadherin encourages castration resistance.", "The HSV-2 infection is typically asymptomatic.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "ATF4 is a general endoplasmic reticulum stress marker.", "De novo assembly of sequence data has fewer specific contigs than unassembled sequence data." ]

[ "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Localization of PIN1 in the roots of Arabidopsis requires VPS9a", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.", "MafA phosphorylation enhances its ubiquitination.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "Mutations in RIM1 decrease levels of IME1 RNA.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK." ]

[ "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "MICAL redox enzymes regulate actin dynamics in many cell types.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis.", "DUSP4 downregulation deactivates the Ras-ERK pathway" ]

[ "Energy balance requires hypothalamic glutamate neurotransmission.", "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "Insulin effects appetite via ventral tegmental neurons.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "Glial calcium waves influence seizures.", "Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis." ]

[ "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "Systemic lupus erythematosus is a risk factor for cardiovascular disease.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.", "Insulin decreases risk of severe kidney failure.", "Monoclonal antibody targeting of N-cadherin inhibits growth.", "Bacteriophagaes MS2 and Qβ are members of the Leviviridae.", "F4/80+ macrophages regulate mature osteoblast maintenance.", "Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.", "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "Eliminating the last sporadic cases of malaria requires considerable funding." ]

[ "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.", "The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies." ]

[ "Microcin J25 encourages nucleoside triphosphate (NTP) binding.", "Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.", "Oxidative DNA damage activates STING signalling.", "Microglia are an innate immune cell type of the central nervous system.", "Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.", "Having a main partner worsens HIV outcomes.", "Increased flux of microbial products suppresses immune responses.", "Aged patients are more susceptible to ischaemia/reperfusion injury.", "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "Cell autonomous sex determination in somatic cells occurs in Galliformes." ]

[ "Environmental factors can influence the development of breast cancer.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Birth-weight is negatively associated with breast cancer.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms." ]

[ "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.", "In the UK, drowning affects boys and girls equally.", "Activation of PPM1D enhances p53 function.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Ethanol stress increases the expression of IBP in bacteria.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "The density of cytokine receptor bearing cells affects the distance over which cytokines act.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin." ]

[ "Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "eRNAs influence is linked to senescence, aging, and carcinogenesis.", "The proliferative capacity of neural progenitors differs across species.", "Progerin induces premature aging in stem cells.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.", "Ethanol stress increases the expression of PSP in bacteria." ]

[ "PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Albendazole is used to treat soil-transmitted helminths.", "Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation." ]

[ "Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.", "Malaria has a high vectorial capacity.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "The innate immune response struggles to remove small numbers of parasites.", "Suboptimal nutrition is a leading cause of premature death", "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "Sepsis related mortality has risen from 2009 to 2014.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks." ]

[ "Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.", "Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.", "A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.", "Hematopoietic Stem Cell purification reaches purity rates above 90%.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.", "53% of perinatal mortality is due to low birth weight.", "Polymeal nutrition increases cardiovascular mortality.", "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.", "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss." ]

[ "Ethanol stress increases the expression of IBP in bacteria.", "Ethanol stress increases the expression of PSP in bacteria.", "Ethanol stress lowers the expression of PSP in bacteria.", "Ethanol stress increases the expression of SRL in bacteria.", "Ethanol stress reduces the expression of SRL in bacteria.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells." ]

[ "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.", "Gastric lavage is an effective treatment for acute paraquat poisoning.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Klf4 is not required for proper myeloid cell differentiation.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.", "Pyridostatin deregulates G2/M progression." ]

[ "Ethanol stress increases the expression of PSP in bacteria.", "Ethanol stress lowers the expression of PSP in bacteria.", "Ethanol stress increases the expression of SRL in bacteria.", "Ethanol stress reduces the expression of SRL in bacteria.", "Ethanol stress increases the expression of IBP in bacteria.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells." ]

[ "LSD1-positive promoters are associated with RNA polymerase II", "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).", "DUSP4 increases apoptosis.", "The PDPN gene deactivates the C-type lectin receptor (CLEC-2).", "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year." ]

[ "Ethanol stress increases the expression of SRL in bacteria.", "Ethanol stress reduces the expression of SRL in bacteria.", "Ethanol stress increases the expression of PSP in bacteria.", "Ethanol stress lowers the expression of PSP in bacteria.", "Ethanol stress increases the expression of IBP in bacteria.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure." ]

[ "miR-142-5P is a known regulator of raised body temperature.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "Microcin J25 inhibits nucleoside triphosphate (NTP) binding.", "RUNX is not expressed in skin tissue.", "Ca2+ cycling is a UCP1-dependent thermogenic mechanism.", "Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.", "The DESMOND program demonstrates no significant impact on biochemical outcomes.", "Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships." ]

[ "Ethanol stress lowers the expression of PSP in bacteria.", "Ethanol stress increases the expression of PSP in bacteria.", "Ethanol stress reduces the expression of SRL in bacteria.", "Ethanol stress increases the expression of SRL in bacteria.", "Ethanol stress increases the expression of IBP in bacteria.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism." ]

[ "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.", "Risedronate increases risk of vertebral and non-vertebral fractures.", "Decrease of p62 in prostate tumor stroma results in defective autophagy.", "Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).", "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "Surfactin producing cells and exopolymer producing cells cooperate to generate \"Van Gogh\" bundles that have sliding abilities on specialized media.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Glycan adaptation is rarely observed in the B-cell repertoire.", "Improvements in OER catalysts show stable activity over several hundred hours." ]

[ "Ethanol stress reduces the expression of SRL in bacteria.", "Ethanol stress increases the expression of SRL in bacteria.", "Ethanol stress increases the expression of PSP in bacteria.", "Ethanol stress lowers the expression of PSP in bacteria.", "Ethanol stress increases the expression of IBP in bacteria.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure." ]

[ "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "1 in 5 million in UK have abnormal PrP positivity.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "Microcin J25 encourages nucleoside triphosphate (NTP) binding.", "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Headaches are correlated with cognitive impairment.", "The mean suicide rate in women is higher after miscarriage than live birth.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus." ]

[ "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Birth-weight is negatively associated with breast cancer.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Medications to treat obesity do not have side effects.", "53% of perinatal mortality is due to low birth weight.", "Medications to treat obesity have unwanted side effects.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Vitamin D deficiency effects birth weight." ]

[ "53% of perinatal mortality is due to low birth weight.", "Lamins are associated with nuclear membrane structure maintenance.", "CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Glial calcium waves influence seizures.", "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "Transplanted human glial progenitor cells can mature in their host animal.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion." ]

[ "Exercise increases cancer mortality rates among Chinese citizens.", "Exercise reduces cancer mortality rates among Chinese citizens.", "The risk of cancer rises with level of alcohol consumption.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "Medications to treat obesity have unwanted side effects.", "Participants who quit smoking reduce lung cancer risk by approximately 50%.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Medications to treat obesity do not have side effects.", "Walking in traffic areas in London improves lung function in elderly adults.", "Obesity decreases life quality." ]

[ "It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.", "Systemic lupus erythematosus is a risk factor for cardiovascular disease.", "Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "5'-nucleotidase metabolizes 6MP.", "DUSP4 decreases apoptosis.", "Low nucleosome occupancy correlates with high methylation levels across species.", "M. stadtmanae induces ASC speck formation in BlaER1 monocytes.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates." ]

[ "Exercise reduces cancer mortality rates among Chinese citizens.", "Exercise increases cancer mortality rates among Chinese citizens.", "The risk of cancer rises with level of alcohol consumption.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "Participants who quit smoking reduce lung cancer risk by approximately 50%.", "Medications to treat obesity have unwanted side effects.", "Walking in traffic areas in London improves lung function in elderly adults.", "Obesity decreases life quality.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Obesity raises life quality." ]

[ "Sepsis related mortality has risen from 2009 to 2014.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Integrated care is ineffective at tackling multiple comorbidities.", "PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.", "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "There is a positive correlation between hip fractures and statin use.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.", "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently." ]

[ "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.", "Having a main partner worsens HIV outcomes.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "ART substantially reduces infectiveness of HIV-positive people." ]

[ "Acute ablation of KRAS causes severe growth impairment.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.", "Marmosets have a brain region homologous to Broca's area.", "Having a main partner worsens HIV outcomes.", "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion." ]

[ "Exposure to fine particulate air pollution is unrelated to anxiety prevalence.", "Headaches are correlated with cognitive impairment.", "Patients with panic anxiety show decreased CSF levels of hypocretin.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Cognitive behavioral therapy is an ineffective treatment for insomnia", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.", "Antidepressants increase the severity of migraines." ]

[ "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "CHOP is a general endoplasmic reticulum stress marker.", "Misunderstandings between doctors and patients can lead to non-adherence.", "LRBA prevents CTLA - 4 recycling.", "Consumption of whole fruits increases the risk of type 2 diabetes.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.", "Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.", "Lack of FGF21 in mice leads to reduced lifespan.", "siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model." ]

[ "Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "p16INK4A degradation is encoded by CDKN2A.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "Activation of PPM1D enhances p53 function.", "Upregulation of PD1 causes the downmodulation of Satb1.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Egr2 regulates the homeostasis of B and T cells." ]

[ "Prescribed exercise training improves quality of life.", "Low nucleosome occupancy correlates with high methylation levels across species.", "5'-nucleotidase metabolizes 6MP.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "Pyridostatin induces double-strand breaks accumulation.", "Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.", "Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "Increased LDL receptors plays a role in the reduction of plasma Lp(a).", "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi." ]

[ "Expression of oncolytic virus antigens as peptides makes relapse more likely.", "Expression of oncolytic virus antigens as peptides permits additional protection against relapse.", "Persister cells provide relapse resistance in cancer patients.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Side effects associated with antidepressants increases risk of stroke.", "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells." ]

[ "Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.", "5'-nucleotidase metabolizes 6MP.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "Inside the body, falciparum parasites reproduce asexually.", "Bariatric surgery reduces colorectal cancer.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "COPI coatmer is involved in lipid homeostasis.", "Bariatric surgery increases rates of postmenopausal breast cancer.", "The amount of publicly available DNA data doubles every 10 months." ]

[ "Expression of oncolytic virus antigens as peptides permits additional protection against relapse.", "Expression of oncolytic virus antigens as peptides makes relapse more likely.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "Persister cells provide relapse resistance in cancer patients.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut." ]

[ "Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.", "Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.", "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "Expression of oncolytic virus antigens as peptides permits additional protection against relapse.", "A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects." ]

[ "F4/80+ macrophages regulate mature osteoblast maintenance.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "TRAP+ osteoclasts regulate mature osteoblast maintenance.", "Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.", "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "Bone marrow cells don't contribute to adult macrophage compartments.", "Klf4 is important for proper myeloid cell differentiation.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium." ]

[ "NR5A2 is important in reverse cholesterol transport in humans.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.", "ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.", "There is no association between HNF4A mutations and diabetes risks.", "The origin of the CRF01_1b2k protein occurred between 1923 and 1956.", "ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue." ]

[ "FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway." ]

[ "Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.", "Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.", "Egr3 regulates the homeostasis of B and T cells.", "The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis." ]

[ "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "In British Men, haplogroup I increases risk of cardiovascular disease by 50%." ]

[ "Charcoal is an effective treatment for acute paraquat poisoning.", "Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "Microcin J25 inhibits nucleoside triphosphate (NTP) binding.", "ART has no effect on the infectiveness of HIV-positive people.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Deltex has no known interactions with eIF3f." ]

[ "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months." ]

[ "Adult tissue-resident macrophages are seeded before birth.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Sudden death can occur in patients with complex ventricular arrhythmias.", "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.", "British female students are bullied more than British male students.", "De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.", "Cell autonomous sex determination in somatic cells occurs in Galliformes.", "Sweet taste receptors on the tongue are deactivated by between 1 and 10 mM glucose.", "Pyridostatin prevents double-strand breaks accumulation." ]

[ "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "The mean suicide rate in women is lower after miscarriage than live birth.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women." ]

[ "0-dimensional biomaterials lack inductive properties.", "Venules have less significant tunica adventitia than arterioles.", "There is no relation between Erythromycin use and hypertrophic pyloric stenosis.", "MICAL redox enzymes regulate actin dynamics.", "Traditional reviews are biased in their interpretations.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "Active Ly49Q prevents neutrophil polarization.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "Misunderstandings between doctors and patients can lead to non-adherence.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation." ]

[ "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women." ]

[ "Retinoic acid receptor-related orphan receptor gamma (RORγ) is a therapeutic target for castration-resistant prostate cancer (CRPC)", "Exercise increases cancer mortality rates among Chinese citizens.", "Myelin sheaths play a role in action potential propagation.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "Microcin J25 inhibits nucleoside triphosphate (NTP) binding.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "Obesity decreases life quality.", "Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia." ]

[ "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms." ]

[ "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.", "Expression of oncolytic virus antigens as peptides makes relapse more likely.", "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "Klf4 is important for proper myeloid cell differentiation.", "There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "In the UK, drowning affects boys and girls equally." ]

[ "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.", "Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Lack of FGF21 in mice leads to reduced lifespan.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Lack of FGF21 in mice increases life expectancy.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis." ]

[ "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "EGR2 is important to myelination of the peripheral nervous system.", "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "The minor G allele of FOXO3 up-regulates IL-10.", "Monoclonal antibody targeting of N-cadherin inhibits growth.", "Clathrin stabilizes the spindle fiber apparatus during mitosis.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "Patients with common epithelial cancers are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas." ]

[ "Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "0-dimensional biomaterials lack inductive properties.", "Lamins have no effect on nuclear membrane structure maintenance.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Myelin sheaths are lipid-rich cellular structures.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "Lamins are associated with nuclear membrane structure maintenance." ]

[ "Rapamycin increases the concentration of triacylglycerols in fruit flies.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "Increased LDL receptors plays a role in the reduction of plasma Lp(a).", "Upregulation of PD1 causes the upregulation of Satb1.", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "Consumption of whole fruits increases the risk of type 2 diabetes.", "Neutrophils produce IL-1β in response to large particles.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels." ]

[ "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "A deficiency of folate increases blood levels of homocysteine.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Vitamin D deficiency effects birth weight.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway." ]

[ "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "The density of cytokine receptor bearing cells affects the distance over which cytokines act.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "Prescribed exercise training improves quality of life.", "Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa." ]

[ "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "53% of perinatal mortality is due to low birth weight.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "The peak incidence of fractures occurs in toddlers." ]

[ "The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).", "Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "β1/Ketel is able to bind microtubules.", "Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.", "Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS)." ]

[ "Forkhead 0 (fox0) transcription factors are involved in apoptosis.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "Mitochondria play a major role in apoptosis.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.", "The minor G allele of FOXO3 up-regulates IL-10." ]

[ "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "The number of unfertilized oocytes in mated hermaphrodites increases with age.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "Input from mental and physical health care professionals is not effective at decreasing homelessness.", "aPKCz causes tumour suppression by affecting glutamine metabolism.", "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "Notch signaling occurs between tumor cells and stromal cells.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma." ]

[ "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.", "Distant CREs are important for transcriptional regulation.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS)." ]

[ "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.", "The number of unfertilized oocytes in mated hermaphrodites increases with age.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.", "Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Oxidative DNA damage inhibits STING signalling.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments." ]

[ "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "JMJD6 slows the hydroxylation of C-terminal lysine", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding." ]

[ "Hematopoietic Stem Cell purification reaches purity rates above 90%.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Polymeal nutrition increases cardiovascular mortality.", "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.", "Mitochondria play a trivial role in calcium homeostasis.", "Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "Recognition of start codons depends on the translation initiation factor IF3.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes." ]

[ "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "The minor G allele of FOXO3 up-regulates IL-10.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis." ]

[ "Sn is present on mature DCs during inflammation in vivo.", "CCL19 is predominantly present within dLNs.", "TNFAIP3 is a glioblastoma tumor enhancer.", "LRBA prevents CTLA - 4 recycling.", "Notch signaling occurs between tumor cells and stromal cells.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Bariatric surgery reduces colorectal cancer.", "Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients." ]

[ "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "The minor G allele of FOXO3 up-regulates IL-10.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis.", "Egr2 regulates the homeostasis of B and T cells." ]

[ "Glycan adaptation involves insertion-deletion events.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis.", "Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.", "Distant CREs are less conserved among species.", "Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene.", "Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population." ]

[ "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "The minor G allele of FOXO3 up-regulates IL-10.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "TNFAIP3 is a glioblastoma tumor suppressor.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines." ]

[ "Aged patients are less susceptible to ischaemia/reperfusion injury.", "Sepsis related mortality has remained stable between 2009-2014.", "Improvements in OER catalysts show stable activity over several hundred hours.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "Recognition of start codons depends on the translation initiation factor IF3.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE)." ]

[ "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "The minor G allele of FOXO3 up-regulates IL-10.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "TNFAIP3 is a glioblastoma tumor suppressor." ]

[ "IL-10 production by monocytes inhibits CD4 + T cell response.", "Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.", "The one-child policy has created a hospitable environment for female infants.", "Microcin J25 inhibits nucleoside triphosphate (NTP) binding.", "Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "Distant CREs are important for transcriptional regulation.", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.", "Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models." ]

[ "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "Deleting Raptor increases G-CSF levels.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "LRBA prevents CTLA - 4 recycling.", "LRBA promotes CTLA - 4 recycling." ]

[ "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "Sympathetic nerve activity is reduced throughout normal pregnancy.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.", "Mitochondria play a major role in energy production.", "LRBA prevents CTLA - 4 recycling.", "Suboptimal nutrition is a leading cause of premature death", "Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "The PDPN gene deactivates the C-type lectin receptor (CLEC-2)." ]

[ "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "Egr3 regulates the homeostasis of B and T cells.", "TNFAIP3 is a glioblastoma tumor suppressor.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "TNFAIP3 is a glioblastoma tumor enhancer.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "The minor G allele of FOXO3 up-regulates IL-10.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells." ]

[ "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.", "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "The recruitment of Wdr5 to its target loci depends on Kat8.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "Intra-cerebroventricular infusion of amyloid-β oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Patients with common epithelial cancers are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Glial calcium waves influence seizures." ]

[ "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "Egr3 regulates the homeostasis of B and T cells.", "TNFAIP3 is a glioblastoma tumor suppressor.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "TNFAIP3 is a glioblastoma tumor enhancer.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "The minor G allele of FOXO3 up-regulates IL-10.", "IL-10 production by monocytes inhibits CD4 + T cell response." ]

[ "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.", "Amitriptyline is an effective treatment for chronic tension-type headaches.", "TMEM27 is a marker for beta cells.", "Anthrax spores remain deadly until affected areas are decontaminated.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "The origin of the CRF01_1b2k protein occurred between 1923 and 1956.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.", "HAND2 methylation is a key step in early endometrial carcinogenesis.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage." ]

[ "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.", "H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Gastric lavage is an effective treatment for acute paraquat poisoning.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD)." ]

[ "Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.", "NR5A2 does not play a role in development of endometrial tissues.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "One in two surgical randomized controlled trials are discontinued early.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Participants who quit smoking reduce lung cancer risk by approximately 50%.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells." ]

[ "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.", "H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.", "Gastric lavage is an effective treatment for acute paraquat poisoning.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD)." ]

[ "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.", "Chenodeoxycholic acid treatment decreases brown adipose tissue activity.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "Specialized functional cell types can be derived from human pluripotent stem cells.", "HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).", "HAND2 methylation is a key step in early endometrial carcinogenesis." ]

[ "Gastric lavage is an effective treatment for acute paraquat poisoning.", "Charcoal is an effective treatment for acute paraquat poisoning.", "Charcoal shows no benefit for acute paraquat poisoning.", "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission." ]

[ "1 in 5 million in UK have abnormal PrP positivity.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Insulin decreases risk of severe kidney failure.", "Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "Trans-acting factors, such as lncRNAs, influence mRNA translation.", "Eliminating the last sporadic cases of malaria requires considerable funding.", "Insulin decreases risk of severe kidney failure.", "JMJD6 slows the hydroxylation of C-terminal lysine", "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation." ]

[ "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "There is a positive correlation between hip fractures and statin use.", "Amitriptyline is an effective treatment for chronic tension-type headaches.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery." ]

[ "Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.", "Polymeal nutrition increases cardiovascular mortality.", "The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.", "Clathrin stabilizes the spindle fiber apparatus during mitosis.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "Sepsis related mortality has remained stable between 2009-2014." ]

[ "General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "Amitriptyline is an effective treatment for chronic tension-type headaches.", "There is a positive correlation between hip fractures and statin use.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "Medications to treat obesity do not have side effects.", "Antidepressants reduce the severity of migraines." ]

[ "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "NR5A2 is important in reverse cholesterol transport in humans.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "CHOP is a general endoplasmic reticulum stress marker.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Oxidative DNA damage inhibits STING signalling.", "Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors." ]

[ "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.", "Trans-acting factors, such as lncRNAs, influence mRNA translation.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.", "Long - range chromatin interactions regulate transcription.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality." ]

[ "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Suboptimal nutrition is a leading cause of premature death", "Increased flux of microbial products suppresses immune responses.", "70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.", "Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "The innate immune response struggles to remove small numbers of parasites.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "CCL19 is predominantly present within dLNs.", "Bariatric surgery leads to positive outcomes in mental health." ]

[ "Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.", "MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "The PPR MDA5 has twenty N-terminal CARD domains.", "The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.", "JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.", "TNFAIP3 is a glioblastoma tumor suppressor.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Mutations in RIM1 raise levels of IME1 RNA.", "Mutations in RIM1 decrease levels of IME1 RNA." ]

[ "There is a positive correlation between hip fractures and statin use.", "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Alirocumab treatment reduces apo(a) fractional clearance rate.", "Treatment with a protein named FN restores regenerative abilities of aged muscles.", "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "eRNAs influence is linked to senescence, aging, and carcinogenesis.", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.", "PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis." ]

[ "Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "Birth-weight is negatively associated with breast cancer.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Medications to treat obesity do not have side effects.", "Medications to treat obesity have unwanted side effects.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "Exercise increases cancer mortality rates among Chinese citizens." ]

[ "Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.", "H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Ethanol stress increases the expression of SRL in bacteria.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines." ]

[ "Genetic deletion of JAM-A increases gut permeability.", "Mutations in RIM1 decrease levels of IME1 RNA.", "Mutations in RIM1 raise levels of IME1 RNA.", "Alirocumab treatment reduces apo(a) fractional clearance rate.", "Glycan adaptation involves insertion-deletion events.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "Increased flux of microbial products provokes immune responses.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.", "Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis." ]

[ "LRBA prevents CTLA - 4 recycling.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.", "The mean suicide rate in women is higher after miscarriage than live birth.", "LSD1-positive promoters are associated with RNA polymerase II" ]

[ "Genomic aberrations of metastases provide information for targeted therapy.", "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Nonsteroidal antinflammatory drugs show potential anticancer indications.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia." ]

[ "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.", "There is no association between HNF4A mutations and diabetes risks.", "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "LRBA promotes CTLA - 4 recycling.", "TRAP+ osteoclasts regulate mature osteoblast maintenance.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Distant CREs are less conserved among species." ]

[ "Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.", "Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.", "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.", "Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis." ]

[ "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Hypocretin neurones suppress panicprone state in rats.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.", "Alteration of origin firing causes changes in termination zones of Okazaki fragments.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Participants who quit smoking reduce lung cancer risk by approximately 50%.", "Egr3 regulates the homeostasis of B and T cells.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles." ]

[ "Glial calcium waves influence seizures.", "Headaches are correlated with cognitive impairment.", "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "Energy balance requires hypothalamic glutamate neurotransmission.", "Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.", "Insulin effects appetite via ventral tegmental neurons.", "Migraine with aura is associated with ischemic stroke.", "Myelin sheaths play a role in action potential propagation.", "Patients with panic anxiety show decreased CSF levels of hypocretin.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities." ]

[ "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "ART substantially reduces infectiveness of HIV-positive people.", "Mutations in RIM1 raise levels of IME1 RNA.", "Satellite cell dysfunction is a key factor in sarcopenia development.", "Bariatric surgery reduces postmenopausal breast cancer.", "Lack of FGF21 in mice leads to reduced lifespan.", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm." ]

[ "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Microglia are an innate immune cell type of the central nervous system.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "G-CSF increases the expansion and infiltration of MDSCs into tumors." ]

[ "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Chemical injury represses transglutaminase 2 activity.", "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms." ]

[ "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "Ethanol stress reduces the expression of SRL in bacteria.", "Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min.", "Transcription rates in S. cerevisiae range between 7 and 12 kb/min.", "Ethanol stress increases the expression of SRL in bacteria.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Ethanol stress lowers the expression of PSP in bacteria.", "Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.", "Ethanol stress increases the expression of PSP in bacteria.", "Ethanol stress increases the expression of IBP in bacteria." ]

[ "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.", "Bariatric surgery reduces colorectal cancer.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Rapamycin increases the concentration of triacylglycerols in fruit flies.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Monoclonal antibody targeting of N-cadherin encourages castration resistance.", "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "Ethanol stress reduces the expression of SRL in bacteria." ]

[ "Glycan adaptation involves insertion-deletion events.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Glycan adaptation is rarely observed in the B-cell repertoire.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "Deleting Raptor increases G-CSF levels.", "Monoclonal antibody targeting of N-cadherin inhibits growth.", "Recognition of start codons depends on the translation initiation factor IF3.", "Trans-acting factors, such as lncRNAs, influence mRNA translation.", "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage." ]

[ "7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.", "Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.", "Normal expression of RUNX1 causes tumorsupressing effects.", "Neutrophils produce IL-1β in response to large particles.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.", "Lack of FGF21 in mice leads to reduced lifespan.", "Lack of FGF21 in mice leads to reduced lifespan." ]

[ "Glycan adaptation is rarely observed in the B-cell repertoire.", "Glycan adaptation involves insertion-deletion events.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "The innate immune response struggles to remove small numbers of parasites.", "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression." ]

[ "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "A deficiency of folate increases blood levels of homocysteine.", "Glial calcium waves influence seizures.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Bariatric surgery leads to positive outcomes in mental health.", "Normal granulomas form in the presence of TNF in Zebrafish.", "Expression of oncolytic virus antigens as peptides makes relapse more likely.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress." ]

[ "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "p16INK4A degradation is encoded by CDKN2A.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years." ]

[ "Long - range chromatin interactions regulate transcription.", "Oxidative DNA damage inhibits STING signalling.", "Expression of oncolytic virus antigens as peptides permits additional protection against relapse.", "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.", "Basophils promote disease development in patients with systemic lupus erythematosus (SLE).", "BiP is a general endoplasmic reticulum stress marker.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Beta-band coherence is diminished for visible stimuli over invisible stimuli." ]

[ "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.", "p16INK4A degradation is encoded by CDKN2A.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "RAD52 is involved in break-induced DNA replication (BIR).", "Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.", "The DdrB protein from Deinococcus radiodurans functions as a pentamer." ]

[ "Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "MICAL redox enzymes regulate actin dynamics in many cell types.", "Risedronate increases risk of vertebral and non-vertebral fractures.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.", "Albendazole is used to treat soil-transmitted helminths.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Birth-weight is negatively associated with breast cancer." ]

[ "Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "5'-nucleotidase metabolizes 6MP.", "Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A." ]

[ "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "Integrated care is successful at tackling multiple comorbidities.", "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.", "Rapamycin delays aging in fruit flies.", "Low nucleosome occupancy correlates with high methylation levels across species.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development." ]

[ "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "MICAL redox enzymes regulate actin dynamics in many cell types.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "Intra-cerebroventricular infusion of amyloid-β oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi." ]

[ "The recruitment of Wdr5 to its target loci depends on Kat8.", "Oxidative DNA damage activates STING signalling.", "Upregulation of PD1 causes the upregulation of Satb1.", "Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.", "The risk of cancer rises with level of alcohol consumption.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Mitochondria play a trivial role in calcium homeostasis.", "Incidence of heart failure increased by 10% in women since 1979.", "Suboptimal nutrition is a leading cause of premature death", "Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs)." ]

[ "H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.", "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Depletion of nitric oxide is responsible for vasospasm.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs." ]

[ "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.", "Bacteriophagaes MS2 and Qβ are members of the Leviviridae.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "Malaria has a high vectorial capacity.", "Transplanted human glial progenitor cells can mature in their host animal.", "p16INK4A degradation is linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "1 in 5 million in UK have abnormal PrP positivity.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Venules have less significant tunica adventitia than arterioles." ]

[ "H4 G94P proteins induce chromatin assembly, which increases free histones.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments." ]

[ "Bariatric surgery reduces colorectal cancer.", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "Intra-cerebroventricular infusion of amyloid-β oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Low nucleosome occupancy correlates with high methylation levels across species.", "Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.", "PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Environmental factors can influence the development of breast cancer.", "De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.", "Suboptimal nutrition is a leading cause of premature death", "Varying expression levels of EBI2 affect the positioning and migration of B cells." ]

[ "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments." ]

[ "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Alteration of origin firing causes changes in termination zones of Okazaki fragments.", "The PRR MDA5 has a C-terminal domain.", "Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.", "The mean suicide rate in women is higher after miscarriage than live birth.", "CCL19 is predominantly present within dLNs.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments." ]

[ "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex." ]

[ "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "ART substantially reduces infectiveness of HIV-positive people.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "ART substantially reduces infectiveness of HIV-positive people.", "RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.", "Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.", "Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.", "7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.", "Lipopolysaccharides have an inflammation independent effect on kidney barrier function." ]

[ "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments." ]

[ "DUSP4 downregulation deactivates the Ras-ERK pathway", "British male students are bullied more than British female students.", "British female students are bullied more than British male students.", "Upregulation of PD1 causes the upregulation of Satb1.", "In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.", "Ethanol stress lowers the expression of PSP in bacteria.", "Ethanol stress increases the expression of PSP in bacteria.", "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "Microcin J25 encourages nucleoside triphosphate (NTP) binding.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates." ]

[ "HAND2 methylation is a key step in early endometrial carcinogenesis.", "Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.", "NR5A2 does not play a role in development of endometrial tissues.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Decrease of p62 in prostate tumor stroma results in defective autophagy.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "EGR2 is important to myelination of the peripheral nervous system.", "eRNAs influence is linked to senescence, aging, and carcinogenesis.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells." ]

[ "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "Klf2 is important for proper myeloid cell function.", "CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS)." ]

[ "HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "MeCP2 influences the synaptic maturation of neurons.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "Microglia are an innate immune cell type of the central nervous system.", "Tirasemtiv targets fast-twitch muscle." ]

[ "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.", "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.", "TNFAIP3 is a glioblastoma tumor suppressor.", "V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.", "Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Sepsis related mortality has risen from 2009 to 2014.", "The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma." ]

[ "HNF4A mutations are associated with macrosomia in infancy.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "There is no association between HNF4A mutations and diabetes risks.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells." ]

[ "Cost effectiveness evaluations based on cRCT data lack external validity.", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.", "Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.", "Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact.", "Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact.", "Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.", "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates." ]

[ "HOXB4 facilitates HSC expansion when co-cultured with HSCs.", "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Klf4 is important for proper myeloid cell differentiation.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "Klf4 is not required for proper myeloid cell differentiation.", "LRBA promotes CTLA - 4 recycling.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "G-CSF increases the expansion and infiltration of MDSCs into tumors." ]

[ "Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.", "Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "HNF4A mutations are associated with macrosomia in infancy.", "Genetic deletion of JAM-A increases gut permeability.", "Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "RAD52 is involved in break-induced DNA replication (BIR).", "Active Ly49Q induces neutrophil polarization.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion." ]

[ "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.", "HOXB4 facilitates HSC expansion when co-cultured with HSCs.", "Klf4 is important for proper myeloid cell differentiation.", "Klf2 is important for proper myeloid cell function.", "Klf4 is not required for proper myeloid cell differentiation.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Bone marrow cells don't contribute to adult macrophage compartments.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells." ]

[ "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.", "Chemical injury represses transglutaminase 2 activity.", "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis." ]

[ "HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.", "Amitriptyline is an effective treatment for chronic tension-type headaches.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells." ]

[ "The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", "Pharmacist attendance at ward rounds reduces adverse events in wards.", "Sepsis related mortality has risen from 2009 to 2014.", "Klf4 is important for proper myeloid cell differentiation.", "The DESMOND program demonstrates no significant impact on biochemical outcomes.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.", "Activation of PPM1D enhances p53 function." ]

[ "Having a main partner improves HIV outcomes.", "Having a main partner worsens HIV outcomes.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "ART substantially reduces infectiveness of HIV-positive people.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "ART has no effect on the infectiveness of HIV-positive people.", "Self-advocacy training is effective at decreasing homelessness.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata." ]

[ "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "Risedronate increases risk of vertebral and non-vertebral fractures.", "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "cSMAC formation represses weak ligand signalling.", "Increased LDL receptors plays a role in the reduction of plasma Lp(a).", "Egr3 regulates the homeostasis of B and T cells.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "Low nucleosome occupancy correlates with high methylation levels across species." ]

[ "Having a main partner worsens HIV outcomes.", "Having a main partner improves HIV outcomes.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "ART has no effect on the infectiveness of HIV-positive people.", "ART substantially reduces infectiveness of HIV-positive people.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission." ]

[ "Intra-cerebroventricular infusion of amyloid-β oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.", "Environmental factors can influence the development of breast cancer.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "ART substantially reduces infectiveness of HIV-positive people.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "Cellular clocks are associated with mitosis timing in NIH 3T3 cells.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "p16INK4A degradation is encoded by CDKN2A." ]

[ "HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).", "A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.", "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "A deficiency of vitamin B12 decreases blood levels of homocysteine." ]

[ "PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.", "British female students are bullied more than British male students.", "Upregulation of PD1 causes the upregulation of Satb1.", "A deficiency of folate increases blood levels of homocysteine.", "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "miR-142-5P is a known regulator of raised body temperature.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK." ]

[ "Headaches are correlated with cognitive impairment.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "Antidepressants increase the severity of migraines.", "Antidepressants reduce the severity of migraines.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "Patients with panic anxiety show decreased CSF levels of hypocretin.", "Exposure to fine particulate air pollution is unrelated to anxiety prevalence.", "Glial calcium waves influence seizures.", "Cognitive behavioral therapy is an ineffective treatment for insomnia" ]

[ "Ribosomopathies have a high degree of cell and tissue specific pathology.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.", "Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.", "Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Tirasemtiv has no effect on cardiac muscle.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "The minor G allele of FOXO3 up-regulates IL-10." ]

[ "Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.", "Energy balance requires hypothalamic glutamate neurotransmission.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "Ethanol stress increases the expression of IBP in bacteria.", "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "Ethanol stress increases the expression of PSP in bacteria.", "Hypothalamic glutamate neurotransmission is unrelated to energy balance." ]

[ "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.", "The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.", "Basophils promote disease development in patients with systemic lupus erythematosus (SLE).", "Mutations in RIM1 raise levels of IME1 RNA.", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines." ]

[ "Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.", "Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments." ]

[ "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.", "The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.", "Microglia are an innate immune cell type of the central nervous system.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Satellite cell dysfunction is a key factor in sarcopenia development.", "The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling." ]

[ "Helminths interfere with immune system control of coinfections by microbial pathogens 16.", "Albendazole is used to treat soil-transmitted helminths.", "Bacteriophagaes MS2 and Qβ are members of the Leviviridae.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates." ]